High | P04637 | Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4 | 0 | 10.232 | 13 | 6 | 11 | 6 | 393 | 43.6 | 6.79 | 4 | 1 | 3 | 2 | 4 | 1 | 4 | 2 | 2823827.906 | 3407042.188 | 3171369.625 | 2664242.438 | 6 | 6 | 6 | 6 | | cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus | cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus;organelle lumen | catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding | "Pf00870, Pf07710, Pf08563" | 7157 | ENSG00000141510.16 | TP53 | 17 | TP53 Regulates Transcription of Caspase Activators and Caspases; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Ovarian tumor domain proteases; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Factors involved in megakaryocyte development and platelet production; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Regulation of TP53 Expression; Regulation of TP53 Activity through Phosphorylation; Transcriptional activation of cell cycle inhibitor p21 ; Pre-NOTCH Transcription and Translation; The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M DNA damage checkpoint; Ub-specific processing proteases; PI5P Regulates TP53 Acetylation; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Methylation; Activation of NOXA and translocation to mitochondria; Association of TriC/CCT with target proteins during biosynthesis; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Interleukin-4 and 13 signaling; Formation of Senescence-Associated Heterochromatin Foci (SAHF); TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Oxidative Stress Induced Senescence; RUNX3 regulates CDKN1A transcription | Viral carcinogenesis; Hepatitis B; Central carbon metabolism in cancer; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Epstein-Barr virus infection; Neurotrophin signaling pathway; Huntington's disease; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; Glioma; Melanoma; HTLV-I infection; Apoptosis; Wnt signaling pathway; Proteoglycans in cancer; Transcriptional misregulation in cancer; p53 signaling pathway; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS); Thyroid cancer; Hepatitis C; Cell cycle; Endocrine resistance; Basal cell carcinoma; Longevity regulating pathway; PI3K-Akt signaling pathway; Platinum drug resistance | 0 |