293_3:P62987

<head><title>293_3:P62987</title></head>


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<table><tr><th>Protein FDR Confidence: Combined</th><th>Accession</th><th>Description</th><th>Exp. q-value: Combined</th><th>Sum PEP Score</th><th>Coverage [%]</th><th># Peptides</th><th># PSMs</th><th># Unique Peptides</th><th># AAs</th><th>MW [kDa]</th><th>calc. pI</th><th># Peptides (by Search Engine): A2 Sequest HT (IgG)</th><th># Peptides (by Search Engine): B2 Sequest HT (Sel1L)</th><th># Peptides (by Search Engine): C2 Sequest HT (WT)</th><th># Peptides (by Search Engine): D2 Sequest HT (HKO)</th><th># PSMs (by Search Engine): A2 Sequest HT (IgG)</th><th># PSMs (by Search Engine): B2 Sequest HT (Sel1L)</th><th># PSMs (by Search Engine): C2 Sequest HT (WT)</th><th># PSMs (by Search Engine): D2 Sequest HT (HKO)</th><th>Abundance: F1: Sample, IgG</th><th>Abundance: F2: Sample, Sel1L</th><th>Abundance: F3: Sample, WT</th><th>Abundance: F4: Sample, HKO</th><th>Abundances Count: F1: Sample, IgG</th><th>Abundances Count: F2: Sample, Sel1L</th><th>Abundances Count: F3: Sample, WT</th><th>Abundances Count: F4: Sample, HKO</th><th>Modifications</th><th>Biological Process</th><th>Cellular Component</th><th>Molecular Function</th><th>Pfam IDs</th><th>Entrez Gene ID</th><th>Ensembl Gene ID</th><th>Gene Symbol</th><th>Chromosome</th><th>Reactome Pathways</th><th>KEGG Pathways</th><th># Razor Peptides</tr>
<tr><td>High</td><td>P62987</td><td>Ubiquitin-60S ribosomal protein L40 OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2</td><td>0</td><td>14.853</td><td>48</td><td>6</td><td>13</td><td>1</td><td>128</td><td>14.7</td><td>9.83</td><td>1</td><td>4</td><td>3</td><td>3</td><td>1</td><td>4</td><td>4</td><td>4</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport</td><td>cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome</td><td>protein binding;structural molecule activity</td><td>"Pf00240, Pf01020, Pf11976, Pf13019, Pf13881, Pf14560"</td><td>7311</td><td>ENSG00000221983.7</td><td>UBA52</td><td>19</td><td>"NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits"</td><td>Ribosome</td><td>0</td></tr>
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