Protein FDR Confidence: Combined	Accession	Description	Exp. q-value: Combined	Sum PEP Score	Coverage [%]	# Peptides	# PSMs	# Unique Peptides	# AAs	MW [kDa]	calc. pI	Abundance Ratio: (Cortex KO) / (Cortex WT)	Abundance Ratio (log2): (Cortex KO) / (Cortex WT)	Abundance Ratio P-Value: (Cortex KO) / (Cortex WT)	Abundance Ratio Adj. P-Value: (Cortex KO) / (Cortex WT)	Abundance Ratio Variability [%]: (Cortex KO) / (Cortex WT)	Abundances (Grouped): Cortex KO	Abundances (Grouped): Cortex WT	Abundances (Grouped) CV [%]: Cortex KO	Abundances (Grouped) CV [%]: Cortex WT	Abundances (Scaled): F1: 129, Sample, Cortex KO, 1	Abundances (Scaled): F1: 130, Sample, Cortex KO, 2	Abundances (Scaled): F1: 131, Sample, Cortex KO, 3	Abundances (Scaled): F1: 126, Sample, Cortex WT, 1	Abundances (Scaled): F1: 127, Sample, Cortex WT, 2	Abundances (Scaled): F1: 128, Sample, Cortex WT, 3	Abundances (Normalized): F1: 129, Sample, Cortex KO, 1	Abundances (Normalized): F1: 130, Sample, Cortex KO, 2	Abundances (Normalized): F1: 131, Sample, Cortex KO, 3	Abundances (Normalized): F1: 126, Sample, Cortex WT, 1	Abundances (Normalized): F1: 127, Sample, Cortex WT, 2	Abundances (Normalized): F1: 128, Sample, Cortex WT, 3	Abundance: F1: 129, Sample, Cortex KO, 1	Abundance: F1: 130, Sample, Cortex KO, 2	Abundance: F1: 131, Sample, Cortex KO, 3	Abundance: F1: 126, Sample, Cortex WT, 1	Abundance: F1: 127, Sample, Cortex WT, 2	Abundance: F1: 128, Sample, Cortex WT, 3	Abundances Count: F1: 129, Sample, Cortex KO, 1	Abundances Count: F1: 130, Sample, Cortex KO, 2	Abundances Count: F1: 131, Sample, Cortex KO, 3	Abundances Count: F1: 126, Sample, Cortex WT, 1	Abundances Count: F1: 127, Sample, Cortex WT, 2	Abundances Count: F1: 128, Sample, Cortex WT, 3	Biological Process	Cellular Component	Molecular Function	Pfam IDs	Entrez Gene ID	Gene Symbol	Chromosome	Reactome Pathways	Ensembl Gene ID	KEGG Pathways	WikiPathways	# Razor Peptides	Modifications
High	Q63932	Dual specificity mitogen-activated protein kinase kinase 2 OS=Mus musculus OX=10090 GN=Map2k2 PE=1 SV=2	0	49.444	25	10	27	4	401	44.4	7.05	0.978	-0.03	0.761489069	0.98861761	9.05	98.9	101.1	18.2	23.73	108.8	109.4	78	111.3	118.7	73.8	587.9	591	421.3	601	641	398.9	551.3	533.4	420.7	538	557.8	398.9	4	4	4	4	4	4	cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus	catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity	"Pf00069, Pf07714"	26396	Map2k2	10	MAP2K and MAPK activation; MAPK1 (ERK2) activation; Signal transduction by L1; RAF activation; Interleukin-20 family signaling; Negative feedback regulation of MAPK pathway	ENSMUSG00000035027.18	Oxytocin signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Acute myeloid leukemia; mTOR signaling pathway; T cell receptor signaling pathway; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; MicroRNAs in cancer; Ras signaling pathway; Prolactin signaling pathway; VEGF signaling pathway; Insulin signaling pathway; Endometrial cancer; Long-term potentiation; Breast cancer; Melanoma; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Hepatitis B; Non-small cell lung cancer; Sphingolipid signaling pathway; B cell receptor signaling pathway; Toll-like receptor signaling pathway; Proteoglycans in cancer; Thyroid hormone signaling pathway; Neurotrophin signaling pathway; Long-term depression; cGMP-PKG signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; Pathways in cancer; Influenza A; Thyroid cancer; PI3K-Akt signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Renal cell carcinoma; GnRH signaling pathway; Natural killer cell mediated cytotoxicity; Prion diseases; Gap junction; Glioma; Fc epsilon RI signaling pathway; EGFR tyrosine kinase inhibitor resistance; Central carbon metabolism in cancer; Choline metabolism in cancer; Estrogen signaling pathway; Chronic myeloid leukemia; Prostate cancer; Endocrine resistance; Bladder cancer; Apoptosis	IL-9 Signaling Pathway; Hypothetical Network for Drug Addiction; EPO Receptor Signaling; IL-5 Signaling Pathway; MicroRNAs in Cardiomyocyte Hypertrophy; Signaling of Hepatocyte Growth Factor Receptor; MAPK Cascade; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-7 Signaling Pathway; ESC Pluripotency Pathways; IL-6 signaling Pathway; IL-2 Signaling Pathway; MAPK signaling pathway; Regulation of Actin Cytoskeleton; EGFR1 Signaling Pathway; Integrin-mediated Cell Adhesion; Insulin Signaling; Focal Adhesion	0

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