Protein FDR Confidence: Combined Accession Description Exp. q-value: Combined Sum PEP Score Coverage [%] # Peptides # PSMs # Unique Peptides # AAs MW [kDa] calc. pI # Peptides (by Search Engine): A2 Sequest HT (IgG 293) # Peptides (by Search Engine): B2 Sequest HT (HKO 293) # Peptides (by Search Engine): C2 Sequest HT (SKO 293) # Peptides (by Search Engine): D2 Sequest HT (WT 293) # PSMs (by Search Engine): A2 Sequest HT (IgG 293) # PSMs (by Search Engine): B2 Sequest HT (HKO 293) # PSMs (by Search Engine): C2 Sequest HT (SKO 293) # PSMs (by Search Engine): D2 Sequest HT (WT 293) "Abundance: F5: Sample, IgG 293" "Abundance: F6: Sample, HKO 293" "Abundance: F7: Sample, SKO 293" "Abundance: F8: Sample, WT 203" "Abundances Count: F5: Sample, IgG 293" "Abundances Count: F6: Sample, HKO 293" "Abundances Count: F7: Sample, SKO 293" "Abundances Count: F8: Sample, WT 203" Modifications Biological Process Cellular Component Molecular Function Pfam IDs Entrez Gene ID Ensembl Gene ID Gene Symbol Chromosome Reactome Pathways KEGG Pathways # Razor Peptides High P35573 Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3 0 505.426 66 92 767 92 1532 174.7 6.76 75 76 88 83 164 162 241 200 470665571.8 427991513.6 735949145.4 575890585 104 103 105 106 metabolic process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;nucleus;organelle lumen catalytic activity;protein binding "Pf06202, Pf14699, Pf14701, Pf14702" 178 ENSG00000162688.16 AGL 1 Neutrophil degranulation; Glycogen breakdown (glycogenolysis) Starch and sucrose metabolism; Metabolic pathways 0 High P04264 "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" 0 256.404 70 43 623 38 644 66 8.12 37 33 38 40 154 104 198 167 1213415994 634488791.7 1391662852 1219456715 57 54 57 59 cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;protein binding;receptor activity;structural molecule activity "Pf00038, Pf01576, Pf05103, Pf05957, Pf12128, Pf13166, Pf13514" 3848 ENSG00000167768.4 KRT1 12 Formation of the cornified envelope; Neutrophil degranulation 6 High P78347 General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2 0 208.272 52 54 445 54 998 112.3 6.39 46 47 48 50 107 111 113 114 197752908.9 204426475.4 202522758.1 213989806.5 56 57 56 56 Met-loss+Acetyl [N-Term] cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus DNA binding;protein binding Pf02946 2969 ENSG00000263001.5 GTF2I 7 Basal transcription factors; cGMP-PKG signaling pathway; Herpes simplex infection 0 High P35527 "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" 0 273.292 79 38 431 37 623 62 5.24 34 30 37 37 100 80 128 123 456077423.3 345804069.8 680087928 593747591.6 51 49 52 52 cell death;cell organization and biogenesis cytosol;membrane;nucleus structural molecule activity "Pf00038, Pf13166" 3857 ENSG00000171403.9 KRT9 17 Formation of the cornified envelope 1 High P35908 "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" 0 195.162 72 42 371 33 639 65.4 8 37 31 39 32 106 67 111 87 530246796.7 207271732.7 421523279.8 280890367 46 46 46 46 cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process cytoskeleton;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf08614, Pf12128, Pf13166" 3849 ENSG00000172867.3 KRT2 12 Formation of the cornified envelope 7 High P13645 "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" 0 180.277 54 31 371 25 584 58.8 5.21 30 26 28 28 109 68 105 89 841675009.4 395401764 865049167.7 598232922 41 38 42 40 cell death;cell differentiation;metabolic process cytoplasm;cytoskeleton;cytosol;membrane;nucleus structural molecule activity "Pf00038, Pf04111" 3858 ENSG00000186395.7 KRT10 17 Formation of the cornified envelope Staphylococcus aureus infection 8 High Q9UPQ9 Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4 0 271.345 48 58 289 58 1833 193.9 6.76 28 44 58 41 39 74 113 63 53410333.62 104585932.7 146071774.2 79132254.88 53 61 63 58 regulation of biological process;response to stimulus cytoplasm;cytosol protein binding;RNA binding "Pf10427, Pf13893" 23112 ENSG00000100354.20 TNRC6B 22 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High P0DMV9 Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1 0 127.583 55 30 209 26 641 70 5.66 22 25 27 26 41 57 61 50 96569267.3 146060720.6 161747508.2 126294705.5 30 28 31 30 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;receptor activity;RNA binding "Pf00012, Pf06723" 3304; 3303 ENSG00000232804.5; ENSG00000234475.5; ENSG00000231555.4; ENSG00000235941.5; ENSG00000204389.9; ENSG00000204388.6; ENSG00000212866.6; ENSG00000237724.5; ENSG00000224501.5 HSPA1B; HSPA1A 6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1 AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; Viral RNP Complexes in the Host Cell Nucleus; HSP90 chaperone cycle for steroid hormone receptors (SHR) Endocytosis; Longevity regulating pathway - multiple species; Prion diseases; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 4 High Q86TM6 E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2 0 102.766 22 19 205 19 617 67.6 6.95 13 17 19 33 78 94 2525937.156 222807615.2 1105290197 1578334917 4 24 28 27 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" 84447 ENSG00000162298.18 SYVN1 11 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes; Hedgehog ligand biogenesis Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 High P38646 "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" 0 139.167 50 33 202 33 679 73.6 6.16 26 24 26 31 47 47 44 64 108704853.9 97753657.64 84632707.13 128469268.8 32 32 32 32 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;mitochondrion;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00012, Pf06723" 3313 ENSG00000113013.12 HSPA9 5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Interleukin-12 family signaling; Cristae formation; Metabolism of proteins Tuberculosis; RNA degradation 0 High P11142 Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1 0 102.783 46 26 199 22 646 70.9 5.52 19 23 22 22 36 54 59 50 40996947.86 60959903.41 77710234.84 63793436.79 22 19 23 23 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00012, Pf02463, Pf06723" 3312 ENSG00000109971.13 HSPA8 11 "Protein methylation; Clathrin-mediated endocytosis; Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; Lysosome Vesicle Biogenesis; CHL1 interactions; AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; mRNA Splicing - Major Pathway; Interleukin-4 and 13 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR)" Endocytosis; Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 0 High P11021 Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2 0 156.867 55 38 184 37 654 72.3 5.16 12 34 36 12 15 73 78 18 33718577.69 191834097.1 200243882.1 39033770.09 30 37 38 31 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00012, Pf01968, Pf06723" 3309 ENSG00000044574.7 HSPA5 9 "Platelet degranulation ; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response; IRE1alpha activates chaperones" Prion diseases; Protein export; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Antigen processing and presentation 1 High P35637 RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1 0 93.198 17 12 181 10 526 53.4 9.36 11 11 11 12 38 46 45 52 80598083.22 103912417.2 103982094.3 152111875.8 14 14 14 15 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" 2521 ENSG00000089280.18 FUS 16 mRNA Splicing - Major Pathway Transcriptional misregulation in cancer 2 High Q9ULH1 "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" 0 147.155 37 35 158 35 1129 125.4 7.31 30 34 24 52 65 41 71179145.21 102960262 46334545.48 35 33 34 cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00018, Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857, Pf14604" 50807 ENSG00000153317.14 ASAP1 8 VxPx cargo-targeting to cilium Endocytosis; Fc gamma R-mediated phagocytosis 0 High P27694 Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2 0 99.988 47 24 154 24 616 68.1 7.21 17 20 21 21 31 44 40 39 64761056.61 107653216.3 70016584 68423380 24 25 25 25 Met-loss [N-Term]; Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding "Pf01336, Pf01485, Pf04057, Pf08646" 6117 ENSG00000132383.11 RPA1 17 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand; SUMOylation of DNA damage response and repair proteins Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High P57678 Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2 0 120.314 37 37 151 37 1058 120 6.04 24 35 32 38 57 56 670703.1836 50221804.45 70402893.37 64104920.95 4 34 36 35 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus protein binding 50628 ENSG00000179409.10 GEMIN4 17 snRNP Assembly RNA transport 0 High P13647 "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" 0 77.064 42 27 137 16 590 62.3 7.74 23 17 21 23 41 23 33 40 50929225 20659573.94 46871890.17 56278486.06 21 18 21 19 cell death;cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf02994, Pf03961, Pf04111, Pf05957, Pf12128" 3852 ENSG00000186081.11 KRT5 12 Formation of the cornified envelope; Type I hemidesmosome assembly 4 High Q9UBU6 Protein FAM8A1 OS=Homo sapiens OX=9606 GN=FAM8A1 PE=1 SV=1 0 102.765 41 14 130 14 413 44.1 7.21 8 13 14 19 49 62 90332.53125 28951959.81 145489727.5 258876832.6 1 11 14 15 membrane Pf06271 51439 ENSG00000137414.5 FAM8A1 6 0 High Q9UHI6 Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2 0 97.178 44 27 127 27 824 92.2 6.95 23 26 22 37 48 42 798225.7148 77104960.72 103537251.1 84973335.64 8 27 28 28 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00270, Pf00271" 11218 ENSG00000064703.11 DDX20 1 snRNP Assembly RNA transport 0 High O14497 AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3 0 100.334 22 32 126 31 2285 241.9 6.7 26 21 13 24 36 32 17 41 32795793.45 27823909.43 15962455.02 34018745.49 31 30 29 30 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus DNA binding;protein binding "Pf01388, Pf12031" 8289 ENSG00000117713.18 ARID1A 1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 1 High P08779 "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" 0 77.994 49 23 124 9 473 51.2 5.05 19 12 21 22 35 17 34 38 9268781.094 760754.7188 7296666.344 11890635.16 9 3 9 9 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;regulation of biological process;response to stimulus cytoskeleton;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf07888, Pf13514" 3868 ENSG00000186832.8 KRT16 17 Formation of the cornified envelope 0 High P02533 "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" 0 82.065 47 23 122 6 472 51.5 5.16 17 12 19 21 35 18 33 36 43512287.51 17094330.46 40106277.96 62418853.02 20 19 21 20 cell death;cell differentiation;cell organization and biogenesis;response to stimulus cytoplasm;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 3861 ENSG00000186847.5 KRT14 17 Formation of the cornified envelope; Type I hemidesmosome assembly 13 High P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2 0 94.782 67 25 111 21 353 37.4 8.95 17 21 16 22 26 33 20 32 63803392.02 83847013.47 71664247.88 111915850.6 24 25 24 24 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3181 ENSG00000122566.20 HNRNPA2B1 7 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway 4 High P48668 "Keratin, type II cytoskeletal 6C OS=Homo sapiens OX=9606 GN=KRT6C PE=1 SV=3" 0 79.505 38 24 111 1 564 60 8 16 11 19 22 26 15 31 39 1636711.875 117831.9453 556888.1875 1257314.5 1 1 1 1 cell death;cell organization and biogenesis;metabolic process cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf13166" 286887; 3853 ENSG00000170465.9 KRT6C; KRT6A 12 Formation of the cornified envelope 0 High P02538 "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" 0 82.465 40 25 110 2 564 60 8 17 11 19 23 26 15 30 39 16179150.84 3584969.336 13993138.63 24034186.69 13 12 14 14 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf04111, Pf13166" 3853 ENSG00000205420.10 KRT6A 12 Formation of the cornified envelope 12 High P19474 E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1 0 83.976 48 25 108 25 475 54.1 6.38 8 16 22 22 12 24 38 34 13280388.68 25312556.3 47225138.89 45842664.41 23 26 26 26 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus;vacuole catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00097, Pf00622, Pf00643, Pf11789, Pf12128, Pf12678, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227" 6737 ENSG00000132109.9 TRIM21 11 STING mediated induction of host immune responses; Antigen processing: Ubiquitination & Proteasome degradation; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA Systemic lupus erythematosus 0 High O60232 Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1 0 80.927 74 8 96 8 199 21.5 5.24 8 8 7 31 52 13 572251.2197 97553789.22 137435618.7 22662623.47 4 10 10 9 Met-loss+Acetyl [N-Term] cell division protein binding Pf06677 10534 ENSG00000173465.7 SSSCA1 11 0 High P13646 "Keratin, type I cytoskeletal 13 OS=Homo sapiens OX=9606 GN=KRT13 PE=1 SV=4" 0 31.97 11 7 93 1 458 49.6 4.96 7 6 6 6 27 20 23 23 272630.1563 46266.39063 1 1 cell death;cell organization and biogenesis;response to stimulus cytoskeleton;cytosol;nucleus protein binding;structural molecule activity Pf00038 3860 ENSG00000171401.14 KRT13 17 Formation of the cornified envelope 0 High P22061 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4 0 63.099 66 13 92 13 227 24.6 7.21 11 13 10 10 21 32 21 18 45798958.66 93069375.34 41441058.69 46553719.14 14 14 14 14 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf01135, Pf01209, Pf05175, Pf06325, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847" 5110 PCMT1 6 Protein repair 0 High Q9NX95 Syntabulin OS=Homo sapiens OX=9606 GN=SYBU PE=1 SV=2 0 107.034 55 25 87 25 663 72.3 6.25 13 23 18 19 44 24 29178068.29 111742239.4 40243640.55 24 26 27 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi;membrane protein binding Pf15290 55638 ENSG00000147642.16 SYBU 8 0 High Q7Z794 "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3" 0 21.363 12 8 85 4 578 61.9 5.99 4 4 6 4 20 14 27 24 55614260.42 43554470.83 94994253.89 78514659.09 3 4 5 3 cell death;cell organization and biogenesis cytoskeleton;cytosol structural molecule activity "Pf00038, Pf03962, Pf13166, Pf14817" 374454 ENSG00000189182.9 KRT77 12 Formation of the cornified envelope 0 High P17844 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1 0 48.096 30 18 81 12 614 69.1 8.92 8 13 16 16 13 18 27 23 14404372.23 26895375.5 28862726.06 24551242.72 14 17 16 16 cell differentiation;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08061" 1655 ENSG00000108654.13 DDX5 17 mRNA Splicing - Major Pathway Spliceosome; Proteoglycans in cancer; Transcriptional misregulation in cancer 5 High P62701 "40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" 0 42.453 57 16 80 16 263 29.6 10.15 14 11 15 13 21 16 23 20 16571745.38 16081610.13 20919429.52 22005478.55 15 16 15 16 cell organization and biogenesis;development;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00900, Pf08071" 6191 ENSG00000198034.10 RPS4X X "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q15233 Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4 0 48.018 39 16 79 15 471 54.2 8.95 10 13 16 11 14 20 27 18 14528556.16 15546096.08 30515160.99 13854927.53 14 14 14 14 defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 4841 ENSG00000147140.15 NONO X 0 High Q96DZ1 Endoplasmic reticulum lectin 1 OS=Homo sapiens OX=9606 GN=ERLEC1 PE=1 SV=1 0 96.499 58 22 78 22 483 54.8 6.28 12 6 22 18 6 54 772236.8125 23760978.05 4546302.035 124120253.1 2 19 16 22 metabolic process;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 27248 ENSG00000068912.13 ERLEC1 2 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High Q9BUJ2 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2 0 45.682 24 15 77 15 856 95.7 6.92 8 14 12 14 11 20 23 23 9947320.691 16952917 20557373.97 18739356.63 14 14 14 14 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf13671" 11100 ENSG00000105323.16 HNRNPUL1 19 mRNA Splicing - Major Pathway Influenza A 0 High P09651 Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5 0 76.919 44 16 76 12 372 38.7 9.13 10 12 13 13 14 22 18 22 18498398.31 23923861.81 24296709.25 25664224.38 13 13 12 12 cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3178 ENSG00000135486.17 HNRNPA1 12 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High P23246 "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" 0 59.187 28 17 76 16 707 76.1 9.44 14 13 16 12 18 19 26 13 20666047.44 21833235.03 38074341.78 21019153.14 15 15 15 16 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 6421 ENSG00000116560.10 SFPQ 1 PTK6 Regulates Proteins Involved in RNA Processing 1 High P51991 Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2 0 56.282 45 16 75 15 378 39.6 9.01 11 13 13 12 15 20 21 19 19938234.11 24828770.59 27573554.92 29646191.34 15 14 15 15 Acetyl [N-Term] metabolic process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding;transporter activity "Pf00076, Pf13893, Pf14259" 220988 ENSG00000170144.20 HNRNPA3 2 mRNA Splicing - Major Pathway Spliceosome 0 High P68104 Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1 0 54.281 35 12 75 12 462 50.1 9.01 9 11 8 11 18 23 15 19 36642066.31 47383284.69 49163481.22 50305288.5 10 11 11 10 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 1915 ENSG00000156508.17 EEF1A1 6 Peptide chain elongation; Protein methylation; Neutrophil degranulation; HSF1 activation RNA transport; Legionellosis 0 High Q06830 Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1 0 27.7 65 11 69 10 199 22.1 8.13 9 8 9 11 16 15 17 21 20734981.13 22111776.69 20827181.36 25003997.94 10 10 10 10 cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00578, Pf08534, Pf10417" 5052 ENSG00000117450.13 PRDX1 1 TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species Peroxisome 1 High Q8NDV7 Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2 0 57.361 15 20 69 19 1962 210.2 7.01 9 17 18 11 11 20 25 13 5482441.469 14010951.05 17982313.33 8080529.094 13 18 17 16 regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi protein binding;RNA binding "Pf10427, Pf13893, Pf14259" 27327 ENSG00000090905.18 TNRC6A 16 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 1 High Q9UBV2 Protein sel-1 homolog 1 OS=Homo sapiens OX=9606 GN=SEL1L PE=1 SV=3 0 101.569 42 22 69 22 794 88.7 5.39 8 3 22 17 3 49 151049.7109 21811916.46 7861543.117 131774657.5 4 13 12 21 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding "Pf00040, Pf08238" 6400 ENSG00000071537.13 SEL1L 14 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; Pre-NOTCH Processing in Golgi; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High Q92945 Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4 0 48.064 29 18 67 18 711 73.1 7.3 10 15 9 12 13 22 14 18 17455524.55 27400935.91 19795205 23785748.97 15 17 16 17 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf07650, Pf09005, Pf13014" 8570 ENSG00000088247.17 KHSRP 19 ATF4 activates genes; KSRP (KHSRP) binds and destabilizes mRNA 0 High Q92922 SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3 0 64.908 21 18 67 13 1105 122.8 5.76 11 15 9 10 16 22 13 16 12088171.03 18306472.83 9114828 11662136.66 19 20 17 18 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding Pf04433 6599 ENSG00000173473.10 SMARCC1 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 6 High P61247 40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2 0 44.88 53 13 67 13 264 29.9 9.73 8 9 12 13 15 15 17 20 10906277.72 9106104.391 13045506.31 13112818.33 10 10 11 11 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01015 6189 ENSG00000145425.9 RPS3A 4 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62424 60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2 0 38.451 42 14 66 14 266 30 10.61 12 12 9 10 18 16 15 17 19108703.09 17703410.45 20384718.16 20741942.88 14 14 14 14 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01248 6130 ENSG00000280858.2; ENSG00000148303.16 RPL7A 9; CHR_HG2030_PATCH Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q04695 "Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2" 0 30.963 21 12 64 2 432 48.1 5.02 10 7 10 12 19 11 15 19 149656.8906 26273.0332 255098.0078 299627.1719 1 1 2 2 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol protein binding;receptor activity;signal transducer activity;structural molecule activity "Pf00038, Pf07888" 3872 ENSG00000128422.15 KRT17 17 Formation of the cornified envelope 0 High O00571 ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3 0 51.362 36 21 63 20 662 73.2 7.18 9 11 16 15 11 12 24 16 8333779.096 11664391.6 28389946.17 15511295.11 17 20 19 18 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 1654 ENSG00000215301.9 DDX3X X Neutrophil degranulation Viral carcinogenesis; Hepatitis B; RIG-I-like receptor signaling pathway 1 High P60709 "Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1" 0 51.905 50 13 62 1 375 41.7 5.48 10 10 9 13 17 13 13 19 18489776.8 13615752.54 14704053.88 23246780.15 12 11 11 12 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;nucleotide binding;protein binding;structural molecule activity Pf00022 60 ENSG00000075624.13 ACTB 7 Formation of annular gap junctions; Cell-extracellular matrix interactions; UCH proteinases; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; Factors involved in megakaryocyte development and platelet production; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Prefoldin mediated transfer of substrate to CCT/TriC; EPHB-mediated forward signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Folding of actin by CCT/TriC; DNA Damage Recognition in GG-NER; Regulation of actin dynamics for phagocytic cup formation; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Clathrin-mediated endocytosis; VEGFA-VEGFR2 Pathway; HATs acetylate histones; RHO GTPases activate IQGAPs; Recycling pathway of L1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Adherens junctions interactions; RHO GTPases Activate WASPs and WAVEs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Gastric acid secretion; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis 11 High P63261 "Actin, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=ACTG1 PE=1 SV=1" 0 51.404 50 13 62 1 375 41.8 5.48 10 11 8 13 17 14 12 19 554424.6406 507634.5469 511338.9375 717902.8281 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus nucleotide binding;protein binding;structural molecule activity Pf00022 71 ENSG00000184009.9 ACTG1 17 Signaling by BRAF and RAF fusions; Formation of annular gap junctions; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Clathrin-mediated endocytosis; Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; RHO GTPases activate IQGAPs; Signaling by RAS mutants; Recycling pathway of L1; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Translocation of GLUT4 to the plasma membrane; Adherens junctions interactions; EPH-ephrin mediated repulsion of cells; Paradoxical activation of RAF signaling by kinase inactive BRAF; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate Formins; Interleukin-20 family signaling Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis 0 High P52272 Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3 0 47.765 29 18 59 18 730 77.5 8.7 10 9 15 14 13 10 19 17 12986762.71 9417823.238 14551749.53 15988143.82 16 15 17 17 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf11532, Pf11608, Pf13893, Pf14259" 4670 ENSG00000099783.11 HNRNPM 19 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High Q92841 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2 0 46.055 25 17 58 11 729 80.2 8.27 6 10 10 15 9 15 14 20 3954953.203 3915759.516 4330786.578 5500486.563 8 8 7 8 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 10521 ENSG00000100201.20 DDX17 22 0 High P51532 Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2 0 56.289 13 21 57 21 1647 184.5 7.88 12 15 14 13 12 17 14 14 10249913.41 17369491.66 9412965.703 12046968 19 20 19 19 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619" 6597 ENSG00000127616.17 SMARCA4 19 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; Formation of the beta-catenin:TCF transactivating complex; Interleukin-7 signaling 0 High P31943 Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4 0 41.215 30 10 55 4 449 49.2 6.3 8 8 8 9 14 14 12 15 14888064.56 16727919.34 16945242.19 18269162.19 10 10 10 10 metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3187 ENSG00000169045.17; ENSG00000284254.1 HNRNPH1 5; CHR_HG30_PATCH mRNA Splicing - Major Pathway; FGFR2 alternative splicing 6 High Q02878 60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3 0 35.26 42 12 54 12 288 32.7 10.58 9 11 8 11 12 16 11 15 17824216.14 17101789.77 17704647.64 20395376.38 12 11 12 12 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf01159, Pf03868" 6128 ENSG00000089009.15 RPL6 12 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q96PK6 RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2 0 39.858 24 13 54 13 669 69.4 9.67 10 7 12 8 13 9 19 13 10096977.44 9872499.453 12197868.06 11086523.3 13 13 13 13 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10432; 100526737 ENSG00000239306.4 RBM14; RBM14-RBM4 11 RUNX2 regulates bone development 0 High Q9Y3I0 RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1 0 35.419 27 10 52 10 505 55.2 7.23 7 10 8 9 11 15 11 15 5054687.875 8077550.172 6338528.094 8106147.219 8 10 8 9 metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf01139 51493 ENSG00000100220.11 C22orf28; RTCB 22 tRNA processing in the nucleus 0 High P28288 ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1 0 55.614 33 18 52 18 659 75.4 9.36 3 14 15 3 21 28 1391258.645 5941729.291 21628784.86 36387920.53 6 16 21 21 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf06472" 5825 ENSG00000117528.11 ABCD3 1 ABC transporters in lipid homeostasis Peroxisome; ABC transporters 0 High P11940 Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2 0 47.312 31 19 51 13 636 70.6 9.5 12 7 15 10 14 8 18 11 11387459.23 6360435.688 14408132.72 10825821.23 17 16 18 17 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding;translation regulator activity "Pf00076, Pf00658, Pf13893, Pf14259" 26986 ENSG00000070756.15 PABPC1 8 AUF1 (hnRNP D0) binds and destabilizes mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA RNA degradation; mRNA surveillance pathway; RNA transport 6 High P07437 Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2 0 50.896 47 14 50 3 444 49.6 4.89 6 9 9 11 12 10 14 14 13835134.33 14923381.3 18484767.83 17853658.3 10 10 10 12 cell division;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;extracellular;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 203068 ENSG00000232575.10; ENSG00000196230.12; ENSG00000227739.10; ENSG00000224156.10; ENSG00000235067.10; ENSG00000229684.10; ENSG00000183311.16; ENSG00000232421.10 TUBB 6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes Pathogenic Escherichia coli infection; Gap junction; Phagosome 10 High Q9UKV8 Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3 0 46.461 26 19 49 16 859 97.1 9.19 8 14 12 11 8 16 14 11 10613716.92 18155469.39 22567444.56 13186304.88 15 17 17 15 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 27161 ENSG00000123908.11 AGO2; EIF2C2 8 Post-transcriptional silencing by small RNAs; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation 3 High P36578 60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5 0 35.066 38 15 49 15 427 47.7 11.06 9 11 10 13 11 11 13 14 16217676.33 16737875.55 16176271.45 17388503.89 14 15 14 15 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00573, Pf14374" 6124 ENSG00000174444.14 RPL4 15 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P19338 Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3 0 35.51 22 14 49 14 710 76.6 4.7 11 9 12 8 12 11 15 11 11126867.64 14356455.47 12027240.56 12475026.19 13 14 13 13 regulation of biological process;response to stimulus cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 4691 ENSG00000115053.15 NCL 2 Major pathway of rRNA processing in the nucleolus and cytosol Pathogenic Escherichia coli infection 0 High P39023 60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2 0 35.777 31 11 48 11 403 46.1 10.18 7 9 9 8 11 13 11 13 10196549.3 10492249.35 8752577.531 10062086.74 10 10 10 11 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00297 6122 ENSG00000100316.15 RPL3 22 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q16637 Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN1 PE=1 SV=1 0 44.669 39 10 47 10 294 31.8 6.55 9 8 10 16 14 17 602842.2031 32175410.7 38895206.63 37137022.29 2 11 10 11 cell organization and biogenesis;cellular component movement;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;transporter activity Pf06003 6606; 6607 ENSG00000205571.13; ENSG00000273772.4; ENSG00000277773.4; ENSG00000172062.16; ENSG00000275349.4 SMN1; SMN2 5; CHR_HSCHR5_1_CTG1_1; CHR_HSCHR5_2_CTG1_1 snRNP Assembly RNA transport 0 High Q08211 ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4 0 44.003 13 14 47 14 1270 140.9 6.84 6 8 13 10 8 10 16 13 9313622.797 8170589.672 9687788.063 10563851.22 14 13 13 13 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717" 1660 ENSG00000135829.16 DHX9 1 TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; mRNA Splicing - Major Pathway; DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0 High P05387 60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1 0 32.598 81 7 46 7 115 11.7 4.54 7 7 6 6 11 10 12 13 19114998.22 14634490.66 17515312.38 16742968.97 8 8 8 8 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;structural molecule activity Pf00428 6181 ENSG00000177600.8 RPLP2 11 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9Y3F4 Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1 0 38.771 49 13 46 13 350 38.4 5.12 11 10 12 17 15 14 427867.0273 11825964.59 13649347.56 15859472.63 5 13 13 13 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding Pf00400 11171 ENSG00000023734.10 STRAP 12 Downregulation of TGF-beta receptor signaling RNA transport 0 High P68371 Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1 0 45.086 38 12 45 1 445 49.8 4.89 4 7 8 12 8 8 13 16 600959.625 685691.75 1007535.625 763580.625 1 1 1 1 cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 10383 ENSG00000188229.5 TUBB4B 9 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 0 High P15880 40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2 0 26.094 37 11 45 11 293 31.3 10.24 6 8 10 11 9 10 12 14 11630114.94 8812657.063 13118461.13 13019913.56 10 10 10 10 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00333, Pf03719" 6187 ENSG00000140988.15 RPS2 16 "Peptide chain elongation; Protein methylation; Eukaryotic Translation Termination; Viral mRNA Translation; RMTs methylate histone arginines; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P45880 Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2 0 43.411 37 10 44 10 294 31.5 7.56 4 9 10 4 17 23 153872.6777 5197161.477 48546657.81 64523586.81 3 9 11 11 regulation of biological process;transport membrane;mitochondrion;nucleus nucleotide binding;protein binding;transporter activity Pf01459 7417 ENSG00000165637.13 VDAC2 10 Mitochondrial calcium ion transport; Ub-specific processing proteases NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High Q92499 ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2 0 38.11 25 15 44 15 740 82.4 7.23 6 10 10 13 7 12 11 14 8249696.828 10155815.67 9855911.578 11939352.75 15 15 15 15 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00622" 1653 ENSG00000079785.14 DDX1 2 tRNA processing in the nucleus 0 High P08621 U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2 0 43.196 32 13 43 13 437 51.5 9.94 1 4 13 7 1 4 29 9 861409.6719 3220089.473 32679291.06 5510360.32 5 11 14 12 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf12220, Pf13893, Pf14259" 6625 ENSG00000104852.14 SNRNP70 19 mRNA Splicing - Major Pathway Spliceosome 0 High O94905 Erlin-2 OS=Homo sapiens OX=9606 GN=ERLIN2 PE=1 SV=1 0 46.458 46 14 42 10 339 37.8 5.62 2 11 14 4 15 23 787626.0391 13676839.81 19829155.13 4 10 10 metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding Pf01145 11160 ENSG00000147475.14 ERLIN2 8 ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by plasma membrane FGFR1 fusions 0 High O75477 Erlin-1 OS=Homo sapiens OX=9606 GN=ERLIN1 PE=1 SV=2 0 48.341 48 16 42 12 348 39.1 7.87 2 13 15 4 16 22 51680.19922 2289710.383 29010885.94 38223220.84 1 6 15 16 4 High O95819 Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2 0 30.678 11 11 42 11 1239 142 7.46 7 7 8 8 8 11 12 11 10293556.77 10818035.55 13296914.48 12145771.59 11 11 11 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00780, Pf07714" 9448 ENSG00000071054.16 MAP4K4 2 Oxidative Stress Induced Senescence MAPK signaling pathway 0 High P23526 Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4 0 30.79 31 12 42 12 432 47.7 6.34 5 11 9 6 7 15 14 6 6512089.109 10002138.75 8262840.063 4869385.422 12 12 11 11 Met-loss+Acetyl [N-Term] defense response;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00670, Pf02254, Pf02826, Pf05221" 191 ENSG00000101444.12 AHCY 20 "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD); Sulfur amino acid metabolism; Methylation" Metabolic pathways; Cysteine and methionine metabolism 0 High P09874 Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4 0 51.855 23 18 41 18 1014 113 8.88 5 7 17 3 5 8 25 3 4030396.195 9254563.25 19202170.94 3459934.094 13 14 15 11 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063" 142 ENSG00000143799.12 PARP1 1 POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); SUMOylation of DNA damage response and repair proteins Base excision repair; NF-kappa B signaling pathway; Apoptosis 0 High P46781 40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3 0 17.412 34 8 40 8 194 22.6 10.65 7 6 8 6 10 8 11 11 11064087.29 8587144.828 12371236.91 12741756.05 8 8 8 8 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity "Pf00163, Pf01479" 6203 ENSG00000274005.3; ENSG00000275323.3; ENSG00000277079.3; ENSG00000278081.3; ENSG00000277359.3; ENSG00000170889.13; ENSG00000274950.4; ENSG00000274626.3; ENSG00000278270.4; ENSG00000274646.4 RPS9 19; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P10412 Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2 0 23.636 31 7 39 3 219 21.9 11.03 5 4 7 6 9 8 10 12 17941809.56 12053077.13 16588527.75 11065511 6 6 6 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00538 3008 ENSG00000168298.6 HIST1H1E 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 4 High P35244 Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1 0 25.745 61 5 39 5 121 13.6 5.08 5 5 5 4 7 12 13 7 9735085.656 16892433.13 9701157.375 11111444.25 5 5 5 5 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding Pf08661 6119 ENSG00000106399.11 RPA3 7 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High P62241 40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2 0 23.36 48 9 38 9 208 24.2 10.32 7 7 8 8 8 9 10 11 11908751.16 10591756.75 10529270.28 13138092.47 9 9 9 9 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01201 6202 ENSG00000142937.11 RPS8 1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P68363 Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1 0 40.125 33 11 37 11 451 50.1 5.06 5 6 10 9 6 7 13 11 11474688.73 11568253.05 18684042.69 15386626.5 10 10 11 11 cell division;cell organization and biogenesis;response to stimulus;transport cytoplasm;cytoskeleton;membrane catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity "Pf00091, Pf03953" 10376 ENSG00000123416.15 TUBA1B 12 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis 0 High P55795 Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1 0 28.321 18 6 36 1 449 49.2 6.3 5 4 5 4 10 8 9 9 187960.4531 474526.6563 213020.0156 249593.2188 1 2 1 1 metabolic process cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3188 ENSG00000126945.8 HNRNPH2 X mRNA Splicing - Major Pathway 0 High P15927 Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1 0 24.993 30 6 36 6 270 29.2 6.15 5 4 4 6 10 7 9 10 25168877.22 43193304.5 25878015.56 27330274.03 7 7 7 7 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf08784 6118 ENSG00000117748.9 RPA2 1 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High P62906 60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2 0 18.258 29 6 34 6 217 24.8 9.94 6 6 6 6 9 9 8 8 6974294.844 6609759.781 8478462.313 10442927.47 6 6 6 6 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00687 4736 ENSG00000198755.10 RPL10A 6 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62750 60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1 0 12.904 28 5 34 5 156 17.7 10.45 4 5 5 5 9 8 9 8 5075427.813 6321833.063 6383777.688 5910259.813 5 5 5 5 cell organization and biogenesis;cell proliferation;metabolic process;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00276, Pf03939" 6147 ENSG00000198242.13 RPL23A 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P55072 Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4 0 63.89 31 18 34 18 806 89.3 5.26 17 11 21 13 1802296.438 2071816.262 28799942.11 15170109.73 2 3 17 16 Met-loss+Acetyl [N-Term] cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401" 7415 ENSG00000165280.15 VCP 9 Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs; Ovarian tumor domain proteases; ABC-family proteins mediated transport; HSF1 activation; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; E3 ubiquitin ligases ubiquitinate target proteins; Neutrophil degranulation; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum; Legionellosis 0 High Q9NR30 Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5 0 23.183 17 11 32 11 783 87.3 9.28 6 4 8 6 8 6 11 7 4532524.875 3676008.719 4759362.422 5191125.406 9 8 9 9 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08152, Pf14617" 9188 ENSG00000165732.12 DDX21 10 Major pathway of rRNA processing in the nucleolus and cytosol; B-WICH complex positively regulates rRNA expression 0 High P16403 Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2 0 17.181 23 5 32 1 213 21.4 10.93 5 2 4 4 10 6 7 9 405753.4063 868554.2813 865892.25 2064670.75 1 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 3006 ENSG00000187837.3 HIST1H1C 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 0 High P61353 60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2 0 13.904 45 6 31 6 136 15.8 10.56 4 5 4 5 6 7 8 10 9603100.563 8868207.125 10136329.97 11908006.06 6 6 6 6 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00467, Pf01777" 6155 ENSG00000131469.12 RPL27 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q13438 Protein OS-9 OS=Homo sapiens OX=9606 GN=OS9 PE=1 SV=1 0 52.254 36 18 31 18 667 75.5 4.87 4 1 18 5 1 25 5060279.516 400206.0625 39005281.86 10 1 16 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane;organelle lumen protein binding Pf07915 10956 ENSG00000135506.15 OS9 12 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High Q92804 TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1 0 20.285 15 6 31 4 592 61.8 8.02 5 5 5 6 7 6 7 11 11031860.69 11731600.34 12296525.34 26375142.88 4 4 4 4 regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" 8148 ENSG00000270647.5; ENSG00000276833.2 TAF15 17; CHR_HSCHR17_7_CTG4 Basal transcription factors; Transcriptional misregulation in cancer 0 High P61254 60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1 0 7.877 26 5 31 5 145 17.2 10.55 5 3 5 5 8 6 9 8 7021076.375 7679495.375 8607712.125 8552395.5 5 5 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00467 6154 ENSG00000161970.12 RPL26 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q99878 Histone H2A type 1-J OS=Homo sapiens OX=9606 GN=H2AC14 PE=1 SV=3 0 17.905 41 5 30 3 128 13.9 10.89 5 5 5 5 5 7 9 9 7627102.406 10989309.09 22757182.66 35630988.63 5 5 5 5 regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 8331; 8330 ENSG00000276368.1 HIST1H2AJ; HIST1H2AK 6 SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Systemic lupus erythematosus; Alcoholism 2 High Q04837 "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" 0 29.481 37 6 30 6 148 17.2 9.6 5 5 4 5 8 8 6 8 9318592.875 9262924.219 6426182.031 10419655.19 5 5 4 5 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen DNA binding;protein binding;RNA binding Pf00436 6742 ENSG00000106028.10 SSBP1 7 Transcriptional activation of mitochondrial biogenesis Homologous recombination; DNA replication; Mismatch repair 0 High P05141 ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7 0 18.718 31 10 30 10 298 32.8 9.69 3 3 9 7 4 4 12 10 3990337.188 3805989.555 7432948.703 8038648.656 10 9 10 10 Met-loss+Acetyl [N-Term] regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;RNA binding;transporter activity Pf00153 292 ENSG00000005022.5 SLC25A5 X Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Regulation of insulin secretion cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High Q92925 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3 0 15.448 18 8 29 6 531 58.9 9.64 5 7 5 7 6 9 6 8 2434817.516 4349116.188 2341753.172 2550865.016 7 7 7 6 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf02201 6603 ENSG00000108604.15 SMARCD2 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 2 High Q96RN5 Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2 0 22.299 8 6 29 6 788 86.7 9.42 4 5 6 5 6 7 10 6 3074214.781 4803872.938 6175571.219 3904157.828 5 5 5 5 metabolic process;regulation of biological process cytoplasm;membrane;nucleus protein binding Pf09606 51586 ENSG00000099917.17 MED15 22 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 High P62249 40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2 0 15.059 38 6 28 6 146 16.4 10.21 5 5 5 6 6 7 6 9 3334774.938 2551509.813 4774611.281 4154580.094 6 6 6 6 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00380 6217 ENSG00000105193.8 RPS16 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q8TAQ2 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1 0 29.685 9 10 28 5 1214 132.8 5.69 4 9 5 5 5 13 5 5 3538954.094 3838850.594 2524224.961 4618110.328 4 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf04433 6601 ENSG00000139613.11 SMARCC2 12 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High P15924 Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3 0 32.313 5 16 28 16 2871 331.6 6.81 8 1 12 4 9 1 14 4 6169089.859 2203083.797 5975830.344 5532565.184 15 12 15 15 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity "Pf00038, Pf00681, Pf01540, Pf01576, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06008, Pf06160, Pf06637, Pf07888, Pf10174, Pf12072, Pf12128, Pf13166" 1832 ENSG00000096696.13 DSP 6 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0 High P62280 40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3 0 20.614 42 8 28 8 158 18.4 10.3 5 7 6 5 6 9 6 7 8076047.281 7009414.734 11224567.92 9822357.484 8 7 8 7 cell differentiation;cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00366 6205 ENSG00000142534.6 RPS11 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P25705 "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" 0 20.382 16 9 27 9 553 59.7 9.13 4 4 7 8 4 4 8 11 1894891.176 1775093.039 4332558 5650085.969 7 8 8 8 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00006, Pf00306, Pf02663, Pf02874, Pf05943" 498 ENSG00000152234.15 ATP5A1 18 Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q00839 Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6 0 20.676 12 11 27 11 825 90.5 6 7 5 7 7 8 5 7 7 5934852.852 5298222.059 6517643.234 7219313.063 9 9 9 9 cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;nucleotide binding;protein binding;RNA binding "Pf00622, Pf13671" 3192 ENSG00000153187.18 HNRNPU 1 mRNA Splicing - Major Pathway Spliceosome 0 High Q9H9G7 Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2 0 23.358 15 9 27 7 860 97.3 9.11 4 7 7 7 4 8 8 7 1312350.359 3882506.844 2517324.844 2162327.563 5 7 6 6 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 192669 ENSG00000126070.19 AGO3; EIF2C3 1 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High Q15366 Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1 0 17.458 36 8 26 5 365 38.6 6.79 4 5 5 5 5 6 8 7 4568162.469 5657129.688 6231044.594 4845425.563 7 7 7 7 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 5094 ENSG00000197111.15 PCBP2 12 Negative regulators of DDX58/IFIH1 signaling; mRNA Splicing - Major Pathway 2 High P62244 40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2 0 16.212 49 8 26 8 130 14.8 10.13 3 5 7 6 5 7 8 6 5631292.031 6533341.656 8771892.461 8069924.152 8 8 8 8 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00410 6210 ENSG00000134419.15 RPS15A 16 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62277 40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2 0 16.607 33 7 26 7 151 17.2 10.54 5 3 7 5 7 3 9 7 6009040.438 4323826.75 6341560.938 6892374.5 7 6 7 6 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00312, Pf08069" 6207 ENSG00000110700.6 RPS13 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P26373 60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4 0 16.7 26 6 26 6 211 24.2 11.65 5 4 6 5 6 6 8 6 6559739.984 8338004.875 9634875.156 10429219.38 6 6 6 6 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01294 6137 ENSG00000167526.13 RPL13 16 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P01857 Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1 0 3.827 5 2 26 2 330 36.1 8.19 2 2 2 2 4 3 11 8 50272273.09 47984930.38 128854178.4 101071104.8 3 3 3 3 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity;metal ion binding;protein binding "Pf07654, Pf08205" 3500 ENSG00000277633.5; ENSG00000211896.7 IGHG1 14; CHR_HSCHR14_3_CTG1 Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis 0 High Q9Y224 "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" 0 22.244 32 7 25 7 244 28.1 6.65 5 5 7 6 5 5 8 7 4124646.023 6951533.523 9222373.25 5435202.188 6 7 7 5 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding;RNA binding Pf10036 51637 ENSG00000087302.8 C14orf166; RTRAF 14 tRNA processing in the nucleus 0 High P83731 60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1 0 19.109 37 7 25 7 157 17.8 11.25 4 4 6 7 4 4 9 8 6886911.25 7102167.688 7033883.688 6171601 7 7 7 7 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01246 6152 ENSG00000114391.12 RPL24 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P18124 60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1 0 16.587 27 8 25 8 248 29.2 10.65 5 5 4 6 6 6 5 8 7436350.063 7956786.188 6337552.406 8565688.75 7 7 6 7 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf00327, Pf08079" 6129 ENSG00000147604.13 RPL7 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62851 40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1 0 11.808 30 5 24 5 125 13.7 10.11 4 3 5 5 6 4 7 7 3602411.875 3028118.359 5236200.875 5078369.375 5 5 5 5 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity Pf03297 6230 ENSG00000280831.2; ENSG00000118181.10 RPS25 11; CHR_HG2217_PATCH "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q7RTS7 "Keratin, type II cytoskeletal 74 OS=Homo sapiens OX=9606 GN=KRT74 PE=1 SV=2" 0 9.955 6 5 24 1 529 57.8 7.71 3 5 4 4 4 7 5 8 631953.375 432906.4375 980065 730295.25 1 1 1 1 cell death;cell organization and biogenesis cytoplasm;cytosol protein binding;structural molecule activity Pf00038 121391 ENSG00000170484.9 KRT74 12 Formation of the cornified envelope 0 High P02768 Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2 0 11.835 8 5 23 5 609 69.3 6.28 3 3 3 5 6 4 6 7 3169795.219 2697204.406 3862441.648 6587887.031 4 5 5 5 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus;organelle lumen antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding Pf00273 213 ENSG00000163631.16 ALB 4 "Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma; Platelet degranulation ; Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR); HDL remodeling; Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR); Transport of organic anions; Recycling of bile acids and salts" Thyroid hormone synthesis 0 High Q01844 RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1 0 18.474 11 5 23 5 656 68.4 9.33 4 4 5 4 4 4 10 5 2787229.953 3038064.594 4870914.156 3647685.156 5 5 5 5 metabolic process;regulation of biological process cytoplasm;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf14259" 2130 ENSG00000182944.17 EWSR1 22 Transcriptional misregulation in cancer 0 High P62269 40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3 0 15.743 34 5 23 5 152 17.7 10.99 4 3 3 5 5 4 5 9 7354006.813 5285406.438 7742755.281 8174076.188 6 6 6 6 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00416 6222 ENSG00000223367.6; ENSG00000096150.9; ENSG00000235650.6; ENSG00000226225.6; ENSG00000231500.6 RPS18 6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62917 60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2 0 21.048 46 8 23 8 257 28 11.03 5 5 6 4 6 5 8 4 8459322 8777072.219 9361699.656 10104387.72 7 7 7 7 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity "Pf00181, Pf03947" 6132 ENSG00000161016.17 RPL8 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P30050 60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1 0 13.941 33 4 23 4 165 17.8 9.42 3 2 2 2 8 5 6 4 8635557.25 9784138.75 9300336 10376996.63 4 4 4 4 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 6136 ENSG00000197958.12 RPL12 9 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P05388 60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 0 17.256 26 7 23 7 317 34.3 5.97 3 4 3 6 4 5 5 9 4786674.313 4773715.5 5019670.031 5148627 6 6 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00428, Pf00466" 6175 ENSG00000089157.15 RPLP0 12 Peptide chain elongation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Interleukin-12 family signaling Ribosome 0 High Q5T9A4 ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1 0 15.4 10 7 22 1 648 72.5 9.2 3 3 4 7 4 4 7 7 516412.625 454542.1875 495207.9844 789854.125 1 1 1 1 transport membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf07726, Pf07728, Pf12037, Pf13207, Pf13401" 83858 ENSG00000160072.19 ATAD3B 1 Neutrophil degranulation 0 High Q969G3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2 0 20.107 18 6 22 6 411 46.6 4.88 5 5 3 4 6 7 4 5 4088790.359 5341241.719 2707720 4052676.188 6 6 5 6 cell differentiation;cell organization and biogenesis;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf00505 6605 ENSG00000073584.18 SMARCE1 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q15370 Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1 0 17.699 47 6 22 6 118 13.1 4.88 3 2 6 5 3 3 10 6 1939841.5 4217499.125 9344007.938 3185557.484 4 5 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding Pf00240 6923 ENSG00000103363.14 TCEB2; ELOB 16 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma 0 High P30793 GTP cyclohydrolase 1 OS=Homo sapiens OX=9606 GN=GCH1 PE=1 SV=1 0 12.47 20 6 22 6 250 27.9 8.56 6 6 5 7 8 7 15986714.44 23190124.19 12098886.47 6 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf01227 2643 ENSG00000131979.18 GCH1 14 "eNOS activation and regulation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" Folate biosynthesis; Metabolic pathways 0 High Q9Y277 Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1 0 29.396 45 10 22 10 283 30.6 8.66 7 10 9 13 182949.3223 956987.8828 8012101.094 11736468.75 2 6 8 8 Met-loss+Acetyl [N-Term] cell communication;defense response;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus nucleotide binding;transporter activity Pf01459 7419 ENSG00000078668.13 VDAC3 8 Mitochondrial calcium ion transport; Ub-specific processing proteases Viral carcinogenesis; NOD-like receptor signaling pathway; Hepatitis B; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High Q9NVI7 ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2 0 16.897 14 8 22 2 634 71.3 8.98 4 3 3 7 5 4 6 7 2832980.797 1617448.688 2682866.063 2983129.469 6 4 6 6 cell growth;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401" 55210 ENSG00000197785.13 ATAD3A 1 4 High P61313 60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2 0 12.852 25 5 21 5 204 24.1 11.62 4 3 4 5 6 3 6 6 4447355.453 4521351.594 4134917.406 4731890.531 5 5 5 5 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00827 6138 ENSG00000174748.18 RPL15 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q07020 60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2 0 16.063 36 6 21 6 188 21.6 11.72 4 3 4 4 6 3 6 6 7548561.25 6882073.438 7543508.375 7638547.688 5 5 5 5 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00828 6141 ENSG00000063177.12 RPL18 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62829 60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1 0 14.734 36 4 21 4 140 14.9 10.51 3 2 4 4 4 2 8 7 2994559.219 4065198.063 5231275.938 4054568.375 4 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00238 9349 ENSG00000125691.12 RPL23 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P14625 Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1 0 19.791 11 8 21 8 803 92.4 4.84 4 7 7 5 9 7 538134.3047 3317893.977 4151468.094 3943894.766 4 7 8 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 7184 ENSG00000166598.14 HSP90B1 12 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ATF6 (ATF6-alpha) activates chaperone genes; Interleukin-4 and 13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Estrogen signaling pathway; PI3K-Akt signaling pathway 0 High Q00610 Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5 0 15.56 5 8 21 8 1675 191.5 5.69 4 5 6 4 5 6 6 4 1965082.125 2179927.281 2649972.266 1868856.297 7 7 7 7 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole protein binding;RNA binding;structural molecule activity "Pf00637, Pf01394, Pf04053, Pf09268, Pf13838" 1213 ENSG00000141367.11 CLTC 17 "Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle 0 High Q5M775 Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1 0 3.172 1 2 21 2 1068 118.5 6.7 2 1 2 1 5 3 5 8 1395691560 1085800602 1228330338 1254015145 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoskeleton;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;transporter activity "Pf00307, Pf01496, Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05478, Pf05667, Pf06160, Pf07888, Pf09730, Pf10174, Pf11971, Pf12128" 92521 ENSG00000128487.16 SPECC1 17 0 High Q01081 Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3 0 13.211 19 5 21 5 240 27.9 8.81 4 3 4 5 4 5 5 7 2121098.547 2457632.594 2630583.344 2734657.75 5 5 5 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;transport nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00076, Pf00642, Pf13893" 7307; 102724594 ENSG00000160201.11; ENSG00000275895.6 U2AF1; LOC102724594; U2AF1L5 21 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Shigellosis 0 High Q15424 Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4 0 12.973 8 7 20 7 915 102.6 5.47 7 3 3 4 8 4 3 5 2193142.117 1852069.672 1196680.594 1787625.969 7 5 4 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 6294 ENSG00000160633.12 SAFB 19 0 High P18621 60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3 0 22.26 42 6 20 6 184 21.4 10.17 4 4 4 4 5 5 6 4 8619175.25 8190758.25 9304522.563 8801254.469 6 6 6 5 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00237 6139 ENSG00000215472.10; ENSG00000265681.7 RPL17 18 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P27635 60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4 0 12.872 21 4 20 4 214 24.6 10.08 3 4 4 4 3 7 5 5 4637334.406 4254589.781 5291910.375 6241576.719 4 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity Pf00252 6134 RPL10 X Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q12906 Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3 0 18.182 8 6 20 6 894 95.3 8.76 5 4 3 4 6 5 4 5 2242530.688 1715169.906 1828825.906 2132782.906 4 4 4 4 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular;membrane;mitochondrion;nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf07528, Pf14709" 3609 ENSG00000129351.17 ILF3 19 0 High Q9P209 Centrosomal protein of 72 kDa OS=Homo sapiens OX=9606 GN=CEP72 PE=1 SV=2 0 14.39 10 6 19 6 647 71.7 6.52 5 6 5 5 9 5 1426406.344 3267563 1989431.906 4 5 5 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding "Pf12799, Pf13855, Pf14580" 55722 ENSG00000112877.7 CEP72 5 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High P67809 Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3 0 22.207 38 7 19 4 324 35.9 9.88 4 5 4 4 5 6 4 4 5531182.102 2262937.945 3441880.094 3986926.25 6 6 5 6 metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf00313 4904 ENSG00000065978.18 YBX1 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway 3 High P62805 Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2 0 17.531 50 5 19 5 103 11.4 11.36 3 2 5 3 3 2 8 6 2173607.063 2701455.938 6474034.531 7830413.594 4 3 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00125, Pf02969, Pf15630" 8359; 8361; 8360; 8363; 8370; 554313; 8365; 8364; 121504; 8367; 8294; 8366; 8362; 8368 ENSG00000197061.4; ENSG00000275126.1; ENSG00000273542.1; ENSG00000197238.4; ENSG00000197837.3; ENSG00000276966.2; ENSG00000158406.4; ENSG00000270882.2; ENSG00000274618.1; ENSG00000278637.1; ENSG00000277157.1; ENSG00000278705.1; ENSG00000270276.2; ENSG00000276180.1 HIST1H4A; HIST1H4F; HIST1H4D; HIST1H4J; HIST2H4A; HIST2H4B; HIST1H4H; HIST1H4C; HIST4H4; HIST1H4E; HIST1H4I; HIST1H4B; HIST1H4K; HIST1H4L 6; 1; 12 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of chromatin organization proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 0 High Q8NCA5 Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2 0 20.487 21 5 19 4 518 55.2 8.95 1 4 4 4 1 7 5 6 2008867.633 2947423.828 3925232.313 3356921.859 4 4 6 5 1 High Q9HCJ0 Trinucleotide repeat-containing gene 6C protein OS=Homo sapiens OX=9606 GN=TNRC6C PE=1 SV=3 0 18.228 4 7 18 6 1690 175.9 6.96 1 4 7 2 2 5 9 2 541767.2969 1370829.742 2091975.039 733485.2031 4 6 6 4 Met-loss+Acetyl [N-Term] regulation of biological process;response to stimulus cytosol protein binding;RNA binding "Pf00076, Pf00627, Pf10427, Pf12938, Pf13893, Pf14259" 57690 ENSG00000078687.17 TNRC6C 17 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High P19013 "Keratin, type II cytoskeletal 4 OS=Homo sapiens OX=9606 GN=KRT4 PE=1 SV=5" 0 8.089 7 4 18 1 520 56.1 6.61 3 2 2 3 5 4 4 5 88347.57031 229906.6094 1 1 0 High Q86YZ3 Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2 0 48.707 15 9 18 9 2850 282.2 10.04 6 7 3 7 8 3 10440111.44 4317382.466 10688836.81 6298095.25 5 2 4 3 cell organization and biogenesis;development;transport cytoplasm;cytoskeleton;extracellular;nucleus;organelle lumen metal ion binding 388697 ENSG00000197915.5 HRNR 1 Neutrophil degranulation 0 High P10809 "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" 0 18.563 12 6 17 6 573 61 5.87 3 3 3 6 4 3 3 7 2149987.438 1462070.297 1920231.969 3609047.281 5 5 5 5 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endosome;membrane;mitochondrion;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding Pf00118 3329 ENSG00000144381.16 HSPD1 2 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Mitochondrial protein import; Metabolism of proteins Type I diabetes mellitus; Tuberculosis; RNA degradation; Legionellosis 0 High Q71UI9 Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3 0 5.927 23 3 17 1 128 13.5 10.58 2 2 2 3 2 4 5 6 68882.11719 80749.67969 202457.0313 247783.9688 1 1 1 1 regulation of biological process chromosome;nucleus DNA binding;protein binding Pf00125 94239 ENSG00000105968.18 H2AFV 7 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Packaging Of Telomere Ends; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening Systemic lupus erythematosus; Alcoholism 0 High O95278 Laforin OS=Homo sapiens OX=9606 GN=EPM2A PE=1 SV=2 0 14.065 24 5 17 5 331 37.1 6.65 2 4 4 3 3 5 5 4 2357184.109 2472622.906 5143759.563 3090198.688 5 4 6 4 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;receptor activity;signal transducer activity "Pf00686, Pf00782, Pf03162, Pf05222" 7957 ENSG00000112425.14 EPM2A 6 Glycogen synthesis; Myoclonic epilepsy of Lafora 0 High P49207 60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3 0 7.539 28 4 17 4 117 13.3 11.47 3 2 3 4 4 3 4 6 6343388.125 6230635.25 6794459.375 8028971.5 4 4 4 4 cell organization and biogenesis;metabolic process;transport cytosol;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01199 6164 ENSG00000109475.16 RPL34 4 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P38159 "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" 0 11.588 18 7 17 7 391 42.3 10.05 4 3 2 5 4 4 2 7 3309857.031 2749762.695 3788577.859 6541191.297 5 5 6 7 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf08081, Pf13893, Pf14259" 27316 ENSG00000147274.14 RBMX X mRNA Splicing - Major Pathway Spliceosome 0 High P61978 Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1 0 19.136 24 9 17 9 463 50.9 5.54 6 1 5 5 6 1 5 5 3765817.742 2626516.031 3900728.875 3596714.266 7 7 7 7 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00013, Pf08067, Pf13014, Pf13083" 3190 ENSG00000165119.20 HNRNPK 9 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Viral carcinogenesis; MicroRNAs in cancer; Spliceosome; Herpes simplex infection 0 High P13639 Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4 0 12.424 7 6 17 6 858 95.3 6.83 3 3 4 3 4 4 5 4 1431131.984 2117918.871 2251369.094 2044728.438 5 5 5 5 Met-loss [N-Term] cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 1938 ENSG00000167658.15 EEF2 19 Peptide chain elongation; Protein methylation; Synthesis of diphthamide-EEF2; Neutrophil degranulation; Uptake and function of diphtheria toxin Oxytocin signaling pathway; AMPK signaling pathway 0 High P46776 60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2 0 13.183 37 5 17 5 148 16.6 11 2 3 2 4 4 4 3 6 5178426.297 4137463.563 4664814.234 5193717.578 4 3 4 4 cell organization and biogenesis;metabolic process;transport cytosol;endoplasmic reticulum;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00828 6157 ENSG00000166441.12 RPL27A 11 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P07814 Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5 0 16.586 6 7 17 7 1512 170.5 7.33 4 4 5 4 4 4 5 4 2760967.938 3069824.734 2526257.469 2717723.188 7 8 7 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497" 2058 ENSG00000136628.17 EPRS 1 tRNA modification in the nucleus and cytosol; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Porphyrin and chlorophyll metabolism; Aminoacyl-tRNA biosynthesis; Metabolic pathways 0 High P62913 60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2 0 6.12 13 2 16 2 178 20.2 9.6 2 2 2 2 4 4 4 4 4394694.625 3336678.875 4465953 4002543.625 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00281, Pf00673" 6135 ENSG00000142676.12 RPL11 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P14923 Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3 0 10.45 11 6 16 6 745 81.7 6.14 5 3 3 2 6 3 4 3 2910005.938 773234.5742 1527775.672 1416432.484 6 5 5 4 cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen protein binding;signal transducer activity;structural molecule activity Pf00514 3728 ENSG00000173801.16 JUP 17 Adherens junctions interactions; Neutrophil degranulation; Formation of the cornified envelope; VEGFR2 mediated vascular permeability Arrhythmogenic right ventricular cardiomyopathy (ARVC); Acute myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer 0 High Q07666 "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" 0 12.233 13 5 16 5 443 48.2 8.66 4 3 3 5 4 3 4 5 1446758.02 1531465.926 1786315.906 2362858.766 5 5 5 5 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 10657 ENSG00000121774.17 KHDRBS1 1 PTK6 Regulates Proteins Involved in RNA Processing 0 High P62266 40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3 0 8.444 22 3 16 3 143 15.8 10.49 3 3 3 3 3 5 4 4 3872402 3755223.813 4548160 4095307.563 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00164 6228 ENSG00000186468.12 RPS23 5 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q8N0W3 L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2 0 18.579 12 9 16 9 1084 117.5 6.25 5 3 5 7 3 6 2831899.82 3104912.906 3459964.766 7 7 8 metabolic process cytoplasm;cytosol catalytic activity;nucleotide binding Pf07959 197258 ENSG00000157353.16 FUK 16 GDP-fucose biosynthesis Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways 0 High P46777 60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3 0 11.012 22 6 16 6 297 34.3 9.72 3 6 4 3 3 6 4 3 2134200.102 2425963.758 2245387.383 2188388.586 5 5 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00861, Pf14204" 6125 ENSG00000122406.12 RPL5 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q13310 Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1 0 21.295 14 8 16 2 644 70.7 9.26 5 7 4 5 7 4 920589.125 506451.5156 750939.6875 634087.7344 2 2 2 2 coagulation;metabolic process cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf00658, Pf13893, Pf14259" 8761 ENSG00000090621.13 PABPC4 1 RNA degradation; mRNA surveillance pathway; RNA transport 0 High Q15369 Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1 0 20.112 50 5 15 5 112 12.5 4.78 1 4 4 1 1 6 6 2 1549852.641 3406116.563 7010560.781 2287098.938 4 4 4 4 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;protein binding;RNA binding Pf03931 6921 ENSG00000154582.16 TCEB1; ELOC 8 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-7 signaling; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of Tat-mediated HIV elongation HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma 0 High P42766 60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2 0 7.204 16 3 15 3 123 14.5 11.05 2 3 2 3 3 4 4 4 3364925.578 3442392.922 3867444.453 3877748.617 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf00831 11224 ENSG00000136942.14 RPL35 9 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9Y3U8 60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3 0 5.668 30 3 15 3 105 12.2 11.59 2 3 3 2 2 4 5 4 4592158.5 4509332.375 5118114 5438781.188 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01158 25873 ENSG00000130255.12 RPL36 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62861 40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1 0 6.496 20 3 15 3 59 6.6 12.15 2 2 3 2 2 4 5 4 1872384.875 1985151.203 3271962.813 2332897.016 3 3 3 3 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;ribosome RNA binding;structural molecule activity Pf04758 2197 FAU 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" 0 High P42167 "Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" 0 19.11 29 9 15 9 454 50.6 9.38 4 9 4 11 879776.875 1008354.305 2891993.516 6270172.594 6 6 8 8 Met-loss [N-Term] regulation of biological process chromosome;cytoplasm;membrane;nucleus DNA binding;protein binding "Pf03020, Pf08198" 7112 ENSG00000120802.13 TMPO 12 Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High Q5QNW6 Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3 0 18.406 36 4 15 4 126 13.9 10.32 2 2 3 4 2 2 4 7 3724250.453 3641497.125 8719961 13588979.56 4 3 5 5 cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 440689 ENSG00000203814.6 HIST2H2BF 1 HDACs deacetylate histones; HATs acetylate histones; Ub-specific processing proteases Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 0 High Q8TEM1 Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3 0 26.018 5 10 15 10 1887 205 6.81 5 10 5 10 2562041.938 722513.125 332382.4844 4348917.125 10 6 2 9 cell organization and biogenesis;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;nucleus protein binding Pf02368 23225 ENSG00000132182.11 NUP210 3 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P39019 40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2 0 11.81 34 6 15 6 145 16.1 10.32 4 3 4 2 4 4 5 2 2931481.313 2220590.656 3927830.75 3737564.938 6 5 5 5 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01090 6223 ENSG00000105372.6 RPS19 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62888 60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2 0 13.909 41 3 15 3 115 12.8 9.63 3 2 2 2 5 2 3 5 1256119.313 1725909.516 938402.3281 1796922.094 2 2 2 2 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01248 6156 ENSG00000156482.10 RPL30 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62847 40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1 0 15.784 26 4 15 4 133 15.4 10.78 3 2 3 4 5 2 4 4 2171780.344 1885597.906 2067186.574 2363324.594 4 4 4 4 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01282 6229 ENSG00000138326.18 RPS24 10 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62753 40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1 0 6.558 12 3 15 3 249 28.7 10.84 3 3 3 3 4 3 4 4 5016860.375 2927142.313 5186329.125 10525909.75 3 2 3 2 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01092 6194 ENSG00000137154.12 RPS6 9 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; mTORC1-mediated signalling; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome; Insulin signaling pathway; HIF-1 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Proteoglycans in cancer; mTOR signaling pathway; PI3K-Akt signaling pathway 0 High Q02543 60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2 0 8.595 20 3 14 3 176 20.7 10.71 3 2 3 3 3 2 5 4 4687214.313 4258937.5 4640163.375 5504911.188 3 3 3 3 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01775 6142 ENSG00000105640.12 RPL18A 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8N1N4 "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" 0 11.012 10 5 14 4 520 56.8 6.02 3 2 3 3 3 3 4 4 1019650.094 308364.9688 1090089.719 1275978.125 3 2 3 4 cell death cytosol structural molecule activity "Pf00038, Pf12128, Pf13166" 196374 ENSG00000170423.12 KRT78 12 Formation of the cornified envelope 0 High P53999 Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3 0 11.427 31 4 14 4 127 14.4 9.6 2 4 3 2 7 5 994225.0586 7869593.563 3741265.625 798525.2773 4 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf02229 10923 ENSG00000113387.11 SUB1 5 0 High O14893 Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1 0 21.322 24 6 14 6 280 31.6 5.58 2 4 6 3 4 7 7032754.719 5785271.359 8283654.406 5 5 5 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding Pf04938 8487 ENSG00000092208.16 GEMIN2 14 snRNP Assembly RNA transport 0 High P63173 60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2 0 10.99 50 3 14 3 70 8.2 10.1 1 2 3 2 1 3 7 3 1298900.422 2037674.141 3404162.688 2135848.063 3 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;ribosome RNA binding;structural molecule activity Pf01781 6169 ENSG00000172809.12 RPL38 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62081 40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1 0 10.317 31 5 14 5 194 22.1 10.1 3 1 5 4 4 1 5 4 3267280.344 2454628.313 3318279.297 3743075.141 5 4 4 5 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01251 6201 ENSG00000171863.12 RPS7 2 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P50914 60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4 0 9.743 16 3 14 3 215 23.4 10.93 3 2 2 2 4 4 3 3 6028713.375 6161404 6528324.375 7170298.5 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01929 9045 ENSG00000188846.13 RPL14 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q93034 Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4 0 10.834 6 4 14 4 780 90.9 7.94 2 3 4 2 2 4 6 2 826910.4531 1057529.188 4023708.625 1104775.938 3 3 4 3 cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus catalytic activity;protein binding;receptor activity;transporter activity "Pf00888, Pf10557" 8065 ENSG00000166266.13 CUL5 11 Downregulation of ERBB2 signaling; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High P49411 "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2" 0 14.382 15 6 13 6 452 49.5 7.61 3 4 3 3 3 4 3 3 2768936.078 2760322.453 2902044.656 3192675.344 6 6 6 6 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 7284 TUFM 16 Mitochondrial translation elongation 0 High P52597 Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3 0 15.722 21 6 13 4 415 45.6 5.58 1 4 3 3 1 5 3 4 1548873.75 2024272.609 1647452.844 1909099.609 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3185 ENSG00000169813.16 HNRNPF 10 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Interleukin-12 family signaling 0 High Q6NVV1 Putative 60S ribosomal protein L13a protein RPL13AP3 OS=Homo sapiens OX=9606 GN=RPL13AP3 PE=5 SV=1 0 4.918 19 2 13 2 102 12.1 10.76 2 1 2 2 4 2 4 3 6529315.25 6047333 4998697.25 6556746.5 2 2 2 2 metabolic process nucleus;ribosome RNA binding;structural molecule activity 645683 RPL13AP3 14 0 High P43243 Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2 0 10.19 7 5 13 5 847 94.6 6.25 5 2 2 4 5 2 2 4 2194363.969 1920229.781 2036186.172 2901283.453 5 5 4 5 defense response;regulation of biological process;response to stimulus membrane;nucleus metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00076, Pf13893, Pf14259" 9782 ENSG00000015479.18; ENSG00000280987.4 MATR3 5 0 High Q9UL18 Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3 0 7.715 6 4 13 2 857 97.2 9.16 2 4 3 3 2 4 4 3 387142.1406 662287.4688 613324.4063 465085.1563 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 26523 ENSG00000092847.11 AGO1; EIF2C1 1 Post-transcriptional silencing by small RNAs; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High P06748 Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2 0 17.721 23 5 13 5 294 32.6 4.78 1 3 2 5 1 4 3 5 5644232.375 5569595.281 5467578.781 5721125.844 5 5 4 5 cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;protein binding;RNA binding Pf03066 4869 ENSG00000181163.13 NPM1 5 Nuclear import of Rev protein; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deposition of new CENPA-containing nucleosomes at the centromere 0 High P32119 Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5 0 8.362 15 3 13 2 198 21.9 5.97 2 2 2 2 4 3 3 3 1088579.781 988733.4063 1022010.688 1137330.719 2 2 2 2 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 7001 ENSG00000167815.11 PRDX2 19 TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species 0 High P62314 Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1 0 11.09 38 3 13 3 119 13.3 11.56 1 2 3 3 1 4 4 4 773413.5156 5394850.75 5587787.75 6580395.875 2 2 3 3 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6632 ENSG00000167088.10 SNRPD1 18 snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Systemic lupus erythematosus 0 High Q9BSE5 "Agmatinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGMAT PE=1 SV=2" 0 13.33 16 4 13 4 352 37.6 7.59 3 3 3 5 4 4 3720296.563 3908122.656 4577362.563 5 4 4 metabolic process mitochondrion catalytic activity;metal ion binding Pf00491 79814 ENSG00000116771.5 AGMAT 1 Agmatine biosynthesis Metabolic pathways; Arginine and proline metabolism 0 High P62899 60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1 0 6.388 20 3 13 3 125 14.5 10.54 2 3 2 3 3 3 3 4 1973073.406 2108363.563 2926956.25 3101366.156 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01198 6160 ENSG00000071082.10 RPL31 2 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P35232 Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1 0 11.47 22 5 13 5 272 29.8 5.76 1 1 4 4 1 1 6 5 677750.9375 646681.9844 1239739.25 1185362.797 3 3 3 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus DNA binding;protein binding Pf01145 5245 ENSG00000167085.11 PHB 17 Paradoxical activation of RAF signaling by kinase inactive BRAF; Processing of SMDT1; RAF activation; Signaling by RAS mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling 0 High P14868 "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" 0 10.061 14 5 12 5 501 57.1 6.55 3 3 4 2 3 3 4 2 1504158.406 1272814.203 1419697.766 1310540.469 5 5 5 5 cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf01336" 1615 ENSG00000115866.10 DARS 2 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High P06576 "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" 0 10.843 13 5 12 5 529 56.5 5.4 1 4 5 1 5 6 170798.4375 451455.2422 1550570.805 1973473.469 1 4 5 5 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cell surface;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00006, Pf00306, Pf02874" 506 ENSG00000110955.8 ATP5B 12 Transcriptional activation of mitochondrial biogenesis; Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q9NV79 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCMTD2 PE=1 SV=2 0 16.468 22 7 12 7 361 41 6.11 1 1 7 1 1 10 1224921.555 1873395.906 7556655.313 1454319.523 5 6 6 5 metabolic process cytoplasm catalytic activity "Pf01135, Pf08242, Pf12847, Pf13847" 55251 ENSG00000280663.4; ENSG00000203880.11 PCMTD2 20; CHR_HSCHR20_1_CTG3 0 High P46778 60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2 0 8.482 16 3 12 3 160 18.6 10.49 3 2 2 3 4 2 3 3 2168579.125 2261436.781 2304563.25 2366763.219 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01157 6144 ENSG00000122026.10 RPL21 13 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9NWZ8 Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1 0 10.463 24 5 12 5 242 28.6 6.8 4 4 3 5 4 3 3514131.344 3869527.625 3560390.688 4 4 4 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus protein binding Pf15348 54960 ENSG00000046647.13 GEMIN8 X snRNP Assembly RNA transport 0 High Q96MG8 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PCMTD1 PE=1 SV=2 0 9.702 13 5 12 5 357 40.7 5.66 2 3 4 2 2 3 5 2 1291066.648 1786769.688 3241324.719 1333082.328 5 5 5 5 metabolic process cytoplasm;membrane catalytic activity "Pf01135, Pf12847, Pf13847" 115294 ENSG00000168300.13 PCMTD1 8 0 High Q96GM5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2 0 10.128 11 6 12 4 515 58.2 9.25 3 5 1 3 3 5 1 3 866946.7031 1171543.859 815803.0703 1079891.938 4 4 4 4 cell organization and biogenesis;regulation of biological process;response to stimulus nucleus protein binding;structural molecule activity "Pf02084, Pf02201" 6602 ENSG00000066117.14 SMARCD1 12 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q02413 Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2 0 14.797 8 6 12 6 1049 113.7 5.03 5 3 4 5 3 4 6703913.422 867498.0781 3035415.359 2640050.25 6 4 5 6 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;membrane metal ion binding;protein binding "Pf00028, Pf01049" 1828 ENSG00000134760.5 DSG1 18 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation Staphylococcus aureus infection 0 High P60866 40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1 0 6.577 19 2 12 2 119 13.4 9.94 2 1 2 2 3 3 3 3 1398407.469 1019990.406 1763987.063 1504570 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00338 6224 ENSG00000008988.9 RPS20 8 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q5T749 Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1 0 18.637 16 5 12 5 579 64.1 8.27 4 4 3 5 4 3 6050903.563 1996339.594 3798794.25 3626601.906 6 4 4 5 cytoplasm protein binding 448834 ENSG00000203786.6 KPRP 1 0 High Q13151 Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1 0 11.691 11 3 12 2 305 30.8 9.29 2 2 2 3 3 2 2 5 929894.8438 1079898.219 1392589.375 1219921.031 2 2 2 2 defense response;metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10949 ENSG00000177733.6 HNRNPA0 5 mRNA Splicing - Major Pathway 0 High P12956 X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2 0 16.747 12 7 11 7 609 69.8 6.64 1 7 1 1 9 1 671028.3779 1106185.957 3973566.938 1022043 4 5 6 5 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf02037, Pf02735, Pf03730, Pf03731" 2547 ENSG00000196419.12 XRCC6 22 2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P46779 60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3 0 8.654 31 4 11 4 137 15.7 12.02 3 2 3 2 3 2 3 3 4770132.313 3899137.688 3895407.25 4051205.656 4 4 4 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01778 6158 ENSG00000108107.14 RPL28 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62979 Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2 0 10.47 28 4 11 4 156 18 9.64 2 1 3 3 2 1 4 4 1119319.23 2206287.414 6309753.375 3846100.719 3 4 4 4 cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00240, Pf01599, Pf11976, Pf13019, Pf13881, Pf14560" 6233 ENSG00000143947.13 RPS27A 2 "NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Formation of the ternary complex, and subsequently, the 43S complex; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; Ribosomal scanning and start codon recognition; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits" Ribosome 0 High Q13247 Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2 0 5.976 7 3 11 3 344 39.6 11.43 2 2 3 1 3 3 4 1 1503443.688 1568298.391 1890312.719 1600564.5 3 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 6431 ENSG00000124193.14 SRSF6 20 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High P08708 40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2 0 17.221 33 3 11 3 135 15.5 9.85 1 2 3 2 1 2 4 4 2640926.094 1892180.813 3211692.219 3762976.313 2 2 3 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf00833 6218 ENSG00000278229.2; ENSG00000182774.10 RPS17; RPS17L 15; CHR_HSCHR15_5_CTG8 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q14103 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1 0 5.868 7 2 11 1 355 38.4 7.81 1 1 2 1 2 4 3 2 797867.8125 1154414.625 2147291.25 971478 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3184 ENSG00000138668.18 HNRNPD 4 mRNA Splicing - Major Pathway 0 High Q15084 Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1 0 14.044 16 4 11 4 440 48.1 5.08 1 3 3 2 1 4 4 2 2345620.781 6387167.906 7252251 6287762.844 4 4 4 4 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 10130 ENSG00000143870.12 PDIA6 2 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High P41252 "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" 0 7.773 3 4 11 4 1262 144.4 6.15 4 3 3 1 4 3 3 1 992093.8438 797417.2109 861388.3984 1029824.523 4 4 4 4 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00133, Pf01406, Pf08264, Pf09334" 3376 ENSG00000196305.17 IARS 9 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High O96019 Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1 0 12.328 16 4 11 4 429 47.4 5.6 3 1 1 3 4 1 2 4 1828148.875 2840280.328 1265049.547 1879769.344 4 4 3 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding Pf00022 86 ENSG00000136518.16 ACTL6A 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; UCH proteinases; DNA Damage Recognition in GG-NER; RMTs methylate histone arginines; HATs acetylate histones 0 High P46782 40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4 0 13.447 25 4 11 4 204 22.9 9.72 2 1 4 4 2 1 4 4 4468510.031 3177076.047 7471406.313 7493683.563 4 4 4 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00177 6193 ENSG00000083845.8 RPS5 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q9P035 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2 0 11.128 12 5 10 5 362 43.1 8.94 3 5 3 7 182149.1523 380411.2656 3206426.078 6039014.078 3 3 5 5 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding "Pf04387, Pf04969" 51495 ENSG00000074696.12 PTPLAD1; HACD3 15 Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 High P62318 Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1 0 10.427 25 2 10 2 126 13.9 10.32 2 2 2 3 3 4 1219747.438 6234767.125 8106635 6953102.125 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6634 ENSG00000100028.11 SNRPD3 22 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome; Systemic lupus erythematosus 0 High P04406 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3 0 15.558 16 4 10 4 335 36 8.46 2 2 2 3 2 2 3 3 1711353.688 1747183.516 1935644.719 2465282.906 4 4 4 4 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00044, Pf02800" 2597 ENSG00000111640.14 GAPDH 12 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Alzheimer's disease; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High Q9H840 Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1 0 6.303 31 2 10 2 131 14.5 7.4 1 2 2 2 4 4 77510.92969 5282522.25 5148213.75 5203993.75 1 2 2 2 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus protein binding Pf11095 79760 ENSG00000142252.10 GEMIN7 19 snRNP Assembly RNA transport 0 High O43143 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2 0 8.864 5 4 10 4 795 90.9 7.46 4 2 3 1 4 2 3 1 1301427.016 1479522.922 1590029.234 1282376.063 4 4 4 4 metabolic process;response to stimulus cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 1665 ENSG00000109606.12 DHX15 4 mRNA Splicing - Major Pathway Spliceosome 0 High P62263 40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3 0 9.682 18 3 10 3 151 16.3 10.05 1 2 2 3 1 2 3 4 2516914 2071891.859 2913918.656 2994506.531 3 3 3 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity Pf00411 6208 ENSG00000164587.11 RPS14 5 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P69905 Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2 0 9.4 24 3 10 3 142 15.2 8.68 3 2 1 1 5 3 1 1 16455632 2152899.625 590388.375 517340.9063 3 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;membrane;organelle lumen antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 3040; 3039 ENSG00000206172.8; ENSG00000188536.12 HBA2; HBA1 16 Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide Malaria; African trypanosomiasis 0 High P18077 60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2 0 4.987 25 3 10 3 110 12.5 11.06 2 3 2 2 2 3 3 2 3080277.188 2381452.844 1090433.594 3239889.125 3 3 2 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01247 6165 ENSG00000182899.14 RPL35A 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P23396 40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2 0 10.424 21 5 10 5 243 26.7 9.66 1 1 4 4 1 1 4 4 3585804.656 2738997.531 6563645.875 3898949.813 5 5 5 4 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity "Pf00189, Pf07650" 6188 ENSG00000149273.14 RPS3 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High O75340 Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1 0 9.891 26 5 10 5 191 21.9 5.4 1 5 2 1 7 2 65054.08984 362965.5703 2886462.156 1186536.156 2 4 5 4 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00036, Pf13405, Pf13499, Pf13833" 10016 ENSG00000249915.7 PDCD6 5 0 High P04843 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1 0 24.095 15 8 10 8 607 68.5 6.38 1 8 1 9 295481.5156 1820942.938 6744916.813 2 7 7 metabolic process cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding;RNA binding Pf04597 6184 ENSG00000163902.11 RPN1 3 Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High P84103 Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1 0 4.772 23 3 9 3 164 19.3 11.65 1 2 2 1 2 3 3 1 1068558.063 1219989.313 1340999.5 1319138.531 2 2 2 2 metabolic process;regulation of biological process;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6428 ENSG00000112081.16 SRSF3 6 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 0 High P11586 "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3" 0 5.662 3 3 9 3 935 101.5 7.3 1 1 3 3 1 1 3 4 928524.8203 1221865.313 1169513.016 1055767.281 3 3 3 3 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00763, Pf01268, Pf02882" 4522 MTHFD1 14 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 High O43390 Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1 0 6.611 5 4 9 4 633 70.9 8.13 3 1 1 4 3 1 1 4 1328346.469 1078770.813 1267349.641 1617927.125 3 3 3 3 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10236 ENSG00000282958.1; ENSG00000125944.18 HNRNPR 1; CHR_HSCHR1_4_CTG3 mRNA Splicing - Major Pathway 0 High P22681 E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2 0 9.406 5 4 9 4 906 99.6 6.54 3 1 2 4 2 3 32222.37891 2126476.781 1206528.578 1268082.906 1 4 4 4 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;vacuole catalytic activity;metal ion binding;protein binding;signal transducer activity "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762, Pf13639, Pf13920, Pf13923, Pf14447, Pf14634, Pf15227" 867 ENSG00000110395.6 CBL 11 Spry regulation of FGF signaling; Cargo recognition for clathrin-mediated endocytosis; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; EGFR downregulation; Negative regulation of MET activity; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Regulation of signaling by CBL; Regulation of KIT signaling; Interleukin-6 family signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; InlB-mediated entry of Listeria monocytogenes into host cell Endocytosis; T cell receptor signaling pathway; Insulin signaling pathway; Ubiquitin mediated proteolysis; Chronic myeloid leukemia; ErbB signaling pathway; Pathways in cancer; Proteoglycans in cancer; Bacterial invasion of epithelial cells 0 High Q9NSB2 "Keratin, type II cuticular Hb4 OS=Homo sapiens OX=9606 GN=KRT84 PE=2 SV=2" 0 4.031 4 3 9 1 600 64.8 7.56 1 2 1 2 2 3 1 3 158913.375 107465.2969 107349.125 289475.6875 1 1 1 1 cell death;cell organization and biogenesis;regulation of biological process cytoskeleton;cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf05557, Pf09726, Pf09728, Pf13514" 3890 ENSG00000161849.3 KRT84 12 Formation of the cornified envelope 0 High Q15011 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1 0 10.787 11 4 9 4 391 43.7 5.25 4 2 7 2 181977.125 4190365.313 2126750.469 1 3 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding Pf00240 9709 ENSG00000051108.14 HERPUD1 16 ATF4 activates genes Protein processing in endoplasmic reticulum 0 High P84098 60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1 0 3.751 10 2 9 2 196 23.5 11.47 2 2 2 2 2 3 2 2 6852813.75 6697001.25 6546255 7558254.25 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01280 6143 ENSG00000108298.9 RPL19 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P05386 60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1 0 5.516 52 2 9 2 114 11.5 4.32 1 1 1 2 2 2 2 3 3774678.75 4846496 2894516.5 3696269.25 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;ribosome enzyme regulator activity;protein binding;structural molecule activity Pf00428 6176 ENSG00000137818.11 RPLP1 15 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P14678 Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2 0 6.339 9 2 9 2 240 24.6 11.19 2 2 2 3 3 3 369260.8281 2370844.063 2424513.5 2016704.813 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6628 ENSG00000125835.18 SNRPB 20 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome; Systemic lupus erythematosus 0 High P16989 Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4 0 10.452 11 4 9 1 372 40.1 9.77 1 3 4 1 3 5 156911.25 436175.5625 121269.0547 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding Pf00313 8531 ENSG00000060138.12 CSDA; YBX3 12 Tight junction 0 High P62910 60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2 0 7.092 25 4 9 4 135 15.9 11.33 2 3 3 2 4 3 3102011.281 3208808.031 3088704.719 3794332.188 4 4 4 4 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01655 6161 ENSG00000144713.12 RPL32 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P42677 40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3 0 8.373 40 4 9 4 84 9.5 9.45 3 3 2 3 4 2 1837403.313 2288275.531 3256863.625 2475544.281 2 3 3 3 cell organization and biogenesis;cell proliferation;metabolic process;transport cytosol;nucleus;ribosome DNA binding;metal ion binding;protein binding;RNA binding;structural molecule activity Pf01667 6232 ENSG00000177954.11 RPS27 1 "Peptide chain elongation; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Separation of Sister Chromatids; SRP-dependent cotranslational protein targeting to membrane; Eukaryotic Translation Termination; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Major pathway of rRNA processing in the nucleolus and cytosol; RHO GTPases Activate Formins; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits" Ribosome 0 High P14866 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2 0 6.742 7 3 9 3 589 64.1 8.22 3 1 3 4 1 4 2115750.344 1298328.344 982864.25 1373325.438 3 3 3 3 metabolic process;regulation of biological process cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3191 ENSG00000282947.1; ENSG00000104824.16 HNRNPL 19; CHR_HG26_PATCH mRNA Splicing - Major Pathway 0 High Q86V81 THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3 0 8.29 19 3 9 3 257 26.9 11.15 1 1 3 2 2 1 4 2 661746.8438 690430.9375 2228212 970732.6563 2 2 2 2 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10189 ALYREF 17 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Transport of the SLBP Dependant Mature mRNA; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA Spliceosome; mRNA surveillance pathway; RNA transport; Herpes simplex infection 0 High Q4VXA5 KH homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KHDC1 PE=2 SV=1 0 9.242 18 3 8 3 237 27.1 8.29 1 1 3 1 1 6 2187993.672 784265.375 10474192.63 2 1 3 membrane RNA binding 80759 ENSG00000135314.12 KHDC1 6 0 High P61513 60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2 0 4.697 41 3 8 3 92 10.3 10.43 1 2 2 3 1 2 2 3 1199353 1060439.156 1341374.563 1532667.25 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity Pf01780 6168 ENSG00000197756.9 RPL37A 2 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P34896 "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" 0 14.302 18 7 8 7 483 53 7.71 7 8 5274069.313 7 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding;RNA binding;translation regulator activity Pf00464 6470 ENSG00000176974.19 SHMT1 17 Metabolism of folate and pterines; Carnitine synthesis "Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism" 0 High Q52LJ0 Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2 0 10.019 12 4 8 3 433 45.5 8.69 2 4 1 2 5 1 707208.5469 855628.4531 628311.0078 632427.043 3 3 3 3 0 High Q9Y383 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2 0 8.957 14 5 8 5 392 46.5 10.01 2 4 1 1 2 4 1 1 1067577.461 2843992.156 1440653.516 988219.4531 4 5 4 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis nucleus;spliceosomal complex protein binding;RNA binding Pf03194 51631 ENSG00000146963.17 LUC7L2 7 0 High P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2 0 5.105 4 3 8 3 812 89.2 9.23 3 2 1 2 3 2 1 2 724950.3984 533981.3359 600333.6563 877888.8906 3 3 2 3 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;protein binding;RNA binding "Pf01189, Pf12847" 4839 ENSG00000111641.11 NOP2 12 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; rRNA modification in the nucleus and cytosol 0 High P35268 60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2 0 2.969 10 1 8 1 128 14.8 9.19 1 1 1 1 2 2 2 2 770409.625 2010321.875 2159566 1419343.5 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01776 6146 ENSG00000116251.9 RPL22 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 Medium Q96C24 Synaptotagmin-like protein 4 OS=Homo sapiens OX=9606 GN=SYTL4 PE=1 SV=2 0.014 1.508 1 1 8 1 671 76 8.98 1 1 1 1 1 3 2 2 118901952 113087864 115484288 132729232 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;membrane metal ion binding;protein binding "Pf00168, Pf02318, Pf02891" 94121 ENSG00000102362.15 SYTL4 X Platelet degranulation 0 High P31942 Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2 0 10.605 18 4 8 3 346 36.9 6.87 2 2 2 2 2 2 2 2 428345.8438 620301.125 817492.8906 1229333.844 2 2 3 3 cell differentiation;metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf14259" 3189 ENSG00000096746.17 HNRNPH3 10 0 High Q14527 Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2 0 7.615 4 3 8 3 1009 113.9 8.6 2 3 2 3 3 2 354499.4219 915539.9375 1170426.625 465776.3516 3 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00097, Pf00176, Pf00271, Pf08797, Pf12678, Pf12861, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227" 6596 ENSG00000071794.15 HLTF 3 E3 ubiquitin ligases ubiquitinate target proteins 0 High P47914 60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2 0 4.545 14 2 7 2 159 17.7 11.66 2 1 1 1 3 2 1 1 4605502.563 3057249.938 4300503.938 4647246.063 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01779 6159 ENSG00000162244.10 RPL29 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q15365 Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2 0 7.123 18 5 7 2 356 37.5 7.09 1 2 2 2 1 2 2 2 202814.6094 227882.3594 78968.11719 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 5093 ENSG00000169564.6 PCBP1 2 mRNA Splicing - Major Pathway Spliceosome 0 High O15260 Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3 0 6.341 9 2 7 2 269 30.4 7.78 1 2 2 1 3 3 289629.3438 2465324 2982611 1 2 2 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf02077 6836 ENSG00000280951.2; ENSG00000148248.13 SURF4 9; CHR_HG2030_PATCH COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation 0 High Q8WXD5 Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1 0 5.383 14 2 7 2 167 18.8 5.12 1 1 2 2 2 3 4690548.813 4636800.688 5099986.594 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus protein binding Pf06372 79833 ENSG00000152147.10 GEMIN6 2 snRNP Assembly RNA transport 0 High P33947 ER lumen protein-retaining receptor 2 OS=Homo sapiens OX=9606 GN=KDELR2 PE=1 SV=1 0.007 1.827 4 1 7 1 212 24.4 8.72 1 1 3 4 1325625 1292017.75 1 1 transport endoplasmic reticulum;Golgi;membrane Pf00810 11014 ENSG00000136240.9 KDELR2 7 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport Vibrio cholerae infection 0 High P07910 Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4 0 4.029 7 2 7 2 306 33.7 5.08 2 1 2 1 2 1 2 2 1651986.594 996133.375 1606065.906 1911950.813 2 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3183 ENSG00000092199.17 HNRNPC 14 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Spliceosome 0 High Q96AG4 Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1 0 6.162 17 4 7 4 307 34.9 9.57 3 2 1 4 2 1 742605.2969 1918903.469 1296981.953 856816.0078 3 3 3 3 endoplasmic reticulum;membrane;nucleus protein binding;RNA binding "Pf12799, Pf13855" 55379 ENSG00000108829.9 LRRC59 17 0 High Q03001 Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4 0.002 2.057 0 1 7 1 7570 860.1 5.25 1 1 1 1 1 2 1 3 27256027 26343132 34838844 40873215.5 1 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus metal ion binding;protein binding "Pf00307, Pf00435, Pf00681, Pf02187, Pf11971, Pf13499, Pf13833" 667 DST 6 Type I hemidesmosome assembly 0 Medium Q96Q89 Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3 0.042 1.128 0 1 7 1 1820 210.5 5.67 1 1 1 1 1 1 2 3 144978160 105463216 173302848 157425184 1 1 1 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf01576, Pf02463, Pf03961, Pf07851, Pf09726" 9585 ENSG00000138182.14 KIF20B 10 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 0 High Q14247 Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2 0 7.838 7 4 7 4 550 61.5 5.4 2 3 2 2 3 2 875884.5 1210781.5 621380.375 1014825.734 2 4 3 3 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane protein binding "Pf00018, Pf02218, Pf07653, Pf14604" 2017 ENSG00000085733.15 CTTN 11 RHO GTPases activate PAKs; Clathrin-mediated endocytosis Tight junction; Pathogenic Escherichia coli infection; Proteoglycans in cancer; Bacterial invasion of epithelial cells; Shigellosis 0 High Q96HS1 "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" 0 7.328 11 4 7 4 289 32 8.68 1 3 3 1 3 3 402825.4961 645361.5664 2013122.844 1209266.742 3 3 4 4 cell communication;cell death;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding;signal transducer activity Pf00300 192111 ENSG00000247077.6 PGAM5 12 TNF signaling pathway 0 High P02100 Hemoglobin subunit epsilon OS=Homo sapiens OX=9606 GN=HBE1 PE=1 SV=2 0.003 2.488 7 1 7 1 147 16.2 8.63 1 1 1 1 3 2 1 1 13908940 1857725.75 671617.5625 542607.0625 1 1 1 1 cell organization and biogenesis;coagulation;response to stimulus;transport cytosol metal ion binding;protein binding;transporter activity Pf00042 3046 ENSG00000213931.5 HBE1 11 Factors involved in megakaryocyte development and platelet production 0 High O75531 Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1 0 7.506 37 3 6 3 89 10.1 6.09 2 3 2 4 229911.1016 674378.0156 3453629.156 4347820.719 2 2 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;nucleus DNA binding;protein binding Pf02961 8815 ENSG00000175334.7 BANF1 11 2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High Q92522 Histone H1.10 OS=Homo sapiens OX=9606 GN=H1-10 PE=1 SV=1 0 5.127 9 2 6 2 213 22.5 10.76 1 1 2 1 1 1 2 2 1319445.5 1146697.063 1149154.313 1300917.344 2 2 2 2 cell organization and biogenesis chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 8971 ENSG00000184897.5 H1FX 3 0 High Q8NFD5 AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=2 0 9.754 2 2 6 1 2236 236 6.73 1 2 2 1 3 2 179980.3125 253676.7188 149496.0781 214992.75 1 1 1 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding "Pf01388, Pf03153, Pf09770, Pf12031" 57492 ENSG00000049618.22 ARID1B 6 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q07065 Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2 0 10.016 7 3 6 3 602 66 5.92 1 2 3 1 2 3 385229.2109 737610.9375 1232977.188 1900087.844 2 3 3 3 metabolic process;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;organelle lumen RNA binding Pf13166 10970 ENSG00000136026.13 CKAP4 12 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Surfactant metabolism; Neutrophil degranulation Protein processing in endoplasmic reticulum 0 High Q15436 Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2 0 4.272 3 2 6 1 765 86.1 7.08 2 1 1 2 2 1 1 2 798838.125 1 cell organization and biogenesis;transport cytoplasm;cytosol;endoplasmic reticulum;membrane metal ion binding;protein binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" 10484 ENSG00000100934.14 SEC23A 14 "Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 High Q9P258 Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2 0 11.108 15 6 6 6 522 56 8.78 6 6 143137.9453 2538172.703 307457.8438 145603.7969 2 6 3 1 cell division;cell organization and biogenesis;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding "Pf00415, Pf13540" 55920 ENSG00000281540.2; ENSG00000179051.13 RCC2 1; CHR_HG2095_PATCH Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins 0 High P08670 Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4 0 8.317 13 5 6 5 466 53.6 5.12 4 1 1 4 1 1 1123367.984 411674.9141 735076.5391 558038.875 5 3 5 4 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186" 7431 ENSG00000026025.15 VIM 10 Interleukin-4 and 13 signaling; Caspase-mediated cleavage of cytoskeletal proteins; Striated Muscle Contraction MicroRNAs in cancer; Epstein-Barr virus infection 0 High P83881 60S ribosomal protein L36a OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2 0 3.208 16 2 6 2 106 12.4 10.58 2 2 2 2 2 2 2172478.063 2032252.75 2115358.063 2228274.25 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00935 6173 ENSG00000241343.9 RPL36A X Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O00264 Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3 0 6.723 13 3 6 3 195 21.7 4.7 1 3 2 4 119204.0898 89203.03906 722347.6484 1340431.891 2 1 3 3 transport endoplasmic reticulum;membrane protein binding Pf00173 10857 ENSG00000101856.9 PGRMC1 X Neutrophil degranulation 0 High P21796 Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2 0 8.196 12 3 6 3 283 30.8 8.54 2 3 2 4 168262.9551 447635.8203 1961840.281 2606714.75 2 2 3 3 cell communication;cell death;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf01459 7416 ENSG00000213585.10 VDAC1 5 Mitochondrial calcium ion transport; Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway 0 High P62273 40S ribosomal protein S29 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2 0 4.532 34 2 6 2 56 6.7 10.13 1 1 2 2 1 1 2 2 1338693.219 830098.9688 1430793.219 1784849.25 2 2 2 2 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome metal ion binding;structural molecule activity Pf00253 6235 ENSG00000213741.9 RPS29 14 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62857 40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1 0 7.815 46 3 6 3 69 7.8 10.7 2 1 1 2 2 1 1 2 997180.4688 774905.3125 1115187.5 1129598.313 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytosol;ribosome protein binding;RNA binding;structural molecule activity Pf01200 6234 ENSG00000233927.4 RPS28 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P32969 60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1 0 2.909 9 2 6 2 192 21.9 9.95 1 2 2 1 1 2 2 1 771441.3438 1029943.719 1182120.188 1084950.344 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00347 6133 ENSG00000163682.15 RPL9 4 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P48047 "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" 0 4.216 12 2 6 2 213 23.3 9.96 1 2 2 1 3 2 190762.3594 230132.5117 576505.6406 671556.9063 2 2 2 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf00213 539 ENSG00000241837.6 ATP5O 21 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q99729 Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2 0 4.82 5 2 6 1 332 36.2 8.21 1 2 1 2 2 2 1763596.813 2355188.563 3039081 2533385.5 1 1 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08143, Pf13893, Pf14259" 3182 HNRNPAB 5 1 High P05023 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1 0 8.832 4 3 6 3 1023 112.8 5.49 3 2 4 2 163543.0469 205032.6094 8976775.5 7592125.438 1 1 2 2 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 476 ENSG00000163399.15 ATP1A1 1 Ion homeostasis; Ion transport by P-type ATPases Bile secretion; cGMP-PKG signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Protein digestion and absorption; Proximal tubule bicarbonate reclamation; Thyroid hormone signaling pathway; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Pancreatic secretion; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Gastric acid secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Mineral absorption 0 High Q99623 Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2 0 3.984 6 2 6 2 299 33.3 9.83 2 2 2 2 2 2 183876.5313 294855.7344 725861.6563 773342.875 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;membrane;mitochondrion;nucleus protein binding Pf01145 11331 ENSG00000215021.8 PHB2 12 Processing of SMDT1 0 High Q00325 "Phosphate carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2" 0 5.325 8 3 6 3 362 40.1 9.38 1 2 3 1 2 3 429129.6367 444454.6523 1241589.422 1551529.563 2 2 3 3 transport membrane;mitochondrion protein binding;transporter activity Pf00153 5250 ENSG00000075415.12 SLC25A3 12 0 High P13010 X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3 0 4.456 3 3 5 3 732 82.7 5.81 3 1 4 1 329447.6719 357235.4844 1290727.094 321781.2813 3 2 3 2 cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf02735, Pf03730, Pf03731, Pf08785" 7520 ENSG00000079246.15 XRCC5 2 2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P12532 "Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1A PE=1 SV=1" 0 6.92 17 3 5 3 417 47 8.34 1 1 2 2 1 2 1049316.75 737865.1875 1315154.563 1 1 2 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding "Pf00217, Pf02807" 1159; 548596 ENSG00000223572.9; ENSG00000237289.9 CKMT1B; CKMT1A 15 Creatine metabolism Metabolic pathways; Arginine and proline metabolism 0 High P50402 Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1 0 4.597 13 2 5 2 254 29 5.5 1 2 2 1 2 2 18293.99609 139454.2031 624012.8047 885015.5938 1 2 2 2 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus protein binding Pf03020 2010 ENSG00000102119.10 EMD X Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM) 0 High Q01130 Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4 0 7.418 11 2 5 2 221 25.5 11.85 2 1 3 2 332092.2188 1532016.063 352923.4375 219698.8594 1 2 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6427 ENSG00000161547.16 SRSF2 17 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2 0 3.346 5 2 5 2 385 44.1 6.23 1 2 2 1 2 2 1305151.563 1548672 1123772.938 1321197.063 2 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf04855 6598 ENSG00000099956.18; ENSG00000275837.3 SMARCB1 22; CHR_HSCHR22_1_CTG7 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q9BTV4 Transmembrane protein 43 OS=Homo sapiens OX=9606 GN=TMEM43 PE=1 SV=1 0 4.672 10 3 5 3 400 44.8 8.13 2 3 2 3 62929.10156 957812.1875 1055500.781 1 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis endoplasmic reticulum;Golgi;membrane;nucleus;organelle lumen protein binding Pf07787 79188 ENSG00000170876.7 TMEM43 3 0 High P62937 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2 0 3.642 17 2 5 2 165 18 7.81 2 1 1 1 2 1 1 1 790125.6875 801234.375 615752.5313 952418.25 2 2 2 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 5478 ENSG00000196262.13 PPIA 7 Budding and maturation of HIV virion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Minus-strand DNA synthesis; Binding and entry of HIV virion; Basigin interactions; APOBEC3G mediated resistance to HIV-1 infection; Uncoating of the HIV Virion; Calcineurin activates NFAT; Platelet degranulation ; Plus-strand DNA synthesis; Integration of provirus; Neutrophil degranulation; Assembly Of The HIV Virion; Interleukin-12 family signaling 0 High P84090 Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1 0 4.785 17 2 5 2 104 12.3 5.92 1 2 1 1 1 2 1 1 1228609.438 1006053.688 1339277.063 1113259.938 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process DNA binding;nucleotide binding;protein binding;RNA binding Pf01133 2079 ENSG00000100632.10 ERH 14 0 High P27708 CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3 0 3.673 1 2 5 2 2225 242.8 6.46 2 1 1 1 2 1 1 1 461077 204074.3594 213935.9531 181944.5938 1 1 1 1 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00117, Pf00185, Pf00289, Pf00988, Pf01979, Pf02142, Pf02222, Pf02729, Pf02786, Pf02787, Pf07478, Pf07722, Pf13147, Pf13535, Pf13594, Pf15632" 790 ENSG00000084774.13 CAD 2 Pyrimidine biosynthesis "Alanine, aspartate and glutamate metabolism; Metabolic pathways; Pyrimidine metabolism" 0 High P09429 High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3 0 5.504 19 3 5 2 215 24.9 5.74 3 1 4 1 263832.4766 2149216.328 573492.0313 151258.5469 2 3 2 1 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;chromosome;cytoplasm;endosome;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00505, Pf09011" 3146 ENSG00000189403.14 HMGB1 13 TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Neutrophil degranulation; Regulation of TLR by endogenous ligand; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activation of DNA fragmentation factor Base excision repair 1 High Q14690 Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3 0 2.605 1 1 5 1 1871 208.6 8.87 1 1 1 1 2 1 1 1 197132.2656 115011.4219 159415.25 206190.5625 1 1 1 1 metabolic process cytosol;nucleus protein binding;RNA binding "Pf00575, Pf13424, Pf13432" 22984 ENSG00000148843.13 PDCD11 10 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 Medium O60437 Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4 0.021 1.315 1 1 5 1 1756 204.6 5.6 1 1 1 2 2 1 20740039.55 20444788.54 22500138.86 21384655.34 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus protein binding;structural molecule activity Pf04111 5493 ENSG00000118898.15 PPL 16 Butyrophilin (BTN) family interactions; Formation of the cornified envelope 0 High P26641 Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3 0 6.411 8 3 5 3 437 50.1 6.67 1 2 2 1 2 2 537811.0156 249688.7969 500726.9063 591235.1406 3 2 3 3 metabolic process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497" 1937 ENSG00000254772.9 EEF1G 11 Eukaryotic Translation Elongation Legionellosis 0 High O95140 Mitofusin-2 OS=Homo sapiens OX=9606 GN=MFN2 PE=1 SV=3 0 2.945 4 2 5 2 757 86.3 6.98 1 1 2 1 1 3 189609.2344 677915.5625 956856.8438 833947.1875 1 2 2 2 cell communication;cell death;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00350, Pf01926, Pf04799" 9927 ENSG00000116688.16 MFN2 1 Factors involved in megakaryocyte development and platelet production; Pink/Parkin Mediated Mitophagy NOD-like receptor signaling pathway 0 Medium Q9H3T3 Semaphorin-6B OS=Homo sapiens OX=9606 GN=SEMA6B PE=1 SV=4 0.025 1.25 3 1 5 1 888 95.2 8.48 1 1 1 1 1 1 2 1 2088010.094 1138825.719 1217694.375 1864306.5 1 1 1 1 cell differentiation;development membrane protein binding "Pf01403, Pf01437" 10501 ENSG00000167680.15 SEMA6B 19 Axon guidance 0 High P36542 "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" 0 5.196 9 3 5 3 298 33 9.22 2 3 2 3 380752.0859 115241.5 1054120.563 1223813.094 3 1 3 3 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity;RNA binding;transporter activity Pf00231 509 ENSG00000165629.19 ATP5C1 10 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q9BQG0 Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2 0 5.318 2 2 5 2 1328 148.8 9.28 2 1 2 2 1 2 643439.9375 439501.8438 516990.0156 626356.9688 2 2 2 2 cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf04931, Pf05793, Pf11593, Pf12815" 10514 ENSG00000132382.14 MYBBP1A 17 B-WICH complex positively regulates rRNA expression 0 High P08238 Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4 0 9.685 7 4 5 4 724 83.2 5.03 3 2 3 2 162398.1563 358589.75 640012.5469 759044.2813 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 3326 ENSG00000096384.19 HSP90AB1 6 Sema3A PAK dependent Axon repulsion; HSF1 activation; Attenuation phase; Neutrophil degranulation; Aryl hydrocarbon receptor signalling; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation 0 High Q96G01 Protein bicaudal D homolog 1 OS=Homo sapiens OX=9606 GN=BICD1 PE=1 SV=3 0 7.953 7 4 4 4 975 110.7 5.81 4 4 116569.6094 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoskeleton;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf02463, Pf04111, Pf05557, Pf09730, Pf09787, Pf10186, Pf12128, Pf13166" 636 ENSG00000151746.13 BICD1 12 COPI-independent Golgi-to-ER retrograde traffic 0 High P54136 "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" 0 5.201 4 3 4 3 660 75.3 6.68 1 2 1 1 2 1 12964737.41 11742537.81 11209529.42 11478507.47 3 3 2 3 metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00750, Pf03485, Pf05746" 5917 ENSG00000113643.8 RARS 5 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High Q16891 MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1 0 6.069 3 2 4 2 758 83.6 6.48 2 2 2 2 111151.5938 739680.1563 986586.3125 1 2 2 cell organization and biogenesis;cellular homeostasis membrane;mitochondrion protein binding;RNA binding Pf09731 10989 ENSG00000132305.20 IMMT 2 Cristae formation 0 High Q96BY9 Store-operated calcium entry-associated regulatory factor OS=Homo sapiens OX=9606 GN=SARAF PE=1 SV=1 0 6.722 11 3 4 3 339 37 7.58 3 4 125146.6328 4158648.25 1474245.031 1 3 3 regulation of biological process;transport endoplasmic reticulum;membrane protein binding Pf06682 51669 ENSG00000133872.13 TMEM66; SARAF 8 0 High Q8N9E0 Protein FAM133A OS=Homo sapiens OX=9606 GN=FAM133A PE=1 SV=1 0 3.181 8 2 4 2 248 28.9 10.1 2 1 3 1 282294.2813 1221941.25 598968.3125 303231.8125 1 1 1 1 protein binding 286499 ENSG00000179083.6 FAM133A X 0 High Q08380 Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1 0.009 1.776 1 1 4 1 585 65.3 5.27 1 1 1 2 1 1 258136.1563 223743.0156 221002.75 407908.8125 1 1 1 1 defense response;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen protein binding;receptor activity "Pf00530, Pf07707" 3959 ENSG00000108679.12 LGALS3BP 17 Platelet degranulation 0 High Q13435 Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2 0 3.227 2 2 4 2 895 100.2 5.67 1 2 1 1 2 1 213202.875 260026.8281 195996.1797 243023.3047 2 2 2 2 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf02037, Pf04037, Pf04046" 10992 ENSG00000087365.15 SF3B2 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9UBF6 RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1 0 4.684 28 2 4 2 113 12.7 5.44 1 2 1 1 2 1 279089.75 487338.6719 1330465.531 409457.0469 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf12678, Pf12861, Pf13639" 9616 ENSG00000114125.13 RNF7 3 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 Medium Q9NYC9 "Dynein heavy chain 9, axonemal OS=Homo sapiens OX=9606 GN=DNAH9 PE=1 SV=3" 0.016 1.356 0 1 4 1 4486 511.6 5.91 1 1 2 2 217545.2188 313243.375 360684.375 322085.2188 1 1 1 1 cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf03028, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781" 1770 ENSG00000007174.17 DNAH9 17 Huntington's disease 0 High P62306 Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1 0 5.509 24 2 4 2 86 9.7 4.67 1 1 1 1 1 2 969637.4375 1460600.625 961910.375 2 2 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6636 ENSG00000139343.10 SNRPF 12 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 High Q9BQE9 B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1 0.005 1.934 3 1 4 1 202 22.2 4.75 1 1 1 1 1 1 1 1 450809.625 475414.9375 448822.0938 438300.125 1 1 1 1 cell death;cell differentiation;regulation of biological process;response to stimulus protein binding Pf04714 9275 ENSG00000106635.7 BCL7B 7 0 High P09661 U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2 0 4.606 10 2 4 2 255 28.4 8.62 1 1 2 1 1 2 123768.1094 525713.9531 488343.7031 460633.375 1 2 2 2 metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex protein binding;RNA binding "Pf12799, Pf13855, Pf14580" 6627 ENSG00000131876.16 SNRPA1 15 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway Spliceosome 0 High P61077 Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1 0 7.798 24 3 4 2 147 16.7 7.8 3 4 226729.3281 1649097 821980.3906 6192300.188 1 3 3 3 cell death;metabolic process;regulation of biological process;response to stimulus cytosol;endosome;membrane catalytic activity;nucleotide binding;protein binding "Pf00179, Pf14461" 7323 ENSG00000109332.19 UBE2D3 4 "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Activated TLR4 signalling; Signaling by BMP; E3 ubiquitin ligases ubiquitinate target proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Negative regulators of DDX58/IFIH1 signaling" Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 1 High P46783 40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1 0 5.616 13 3 4 3 165 18.9 10.15 3 1 3 1 1218743.359 823080.4375 1499793.906 326281.9688 2 1 2 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf03501 6204 ENSG00000124614.13 RPS10 6 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q92785 Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2 0 5.708 14 4 4 4 391 44.1 6.33 3 1 3 1 576041.6797 894156.0313 660597.2969 1068007.5 3 3 3 3 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;metal ion binding;protein binding "Pf00628, Pf14051" 5977 ENSG00000133884.9 DPF2 11 0 High Q9BQB6 Vitamin K epoxide reductase complex subunit 1 OS=Homo sapiens OX=9606 GN=VKORC1 PE=1 SV=1 0 3.785 8 1 4 1 163 18.2 9.36 1 1 2 2 37607.44531 186906.4844 731007.4375 1431537.25 1 1 1 1 coagulation;metabolic process endoplasmic reticulum;membrane catalytic activity Pf07884 79001 ENSG00000167397.14 VKORC1 16 Metabolism of vitamin K Ubiquinone and other terpenoid-quinone biosynthesis 0 High Q5T750 Skin-specific protein 32 OS=Homo sapiens OX=9606 GN=XP32 PE=1 SV=1 0 3.272 8 2 4 2 250 26.2 7.97 2 1 1 2 1 1 1311780.875 255105.5781 1235965.438 686114.9063 2 1 2 2 cell differentiation;metabolic process cytoplasm;cytoskeleton structural molecule activity 100129271 ENSG00000198854.5 C1orf68 1 0 High Q12905 Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2 0 3.337 4 1 4 1 390 43 5.26 1 1 1 1 1 1 1 1 241836.5 324174.125 286812.5313 341555.1875 1 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding Pf07528 3608 ENSG00000143621.16 ILF2 1 Neutrophil degranulation 0 High Q96EP5 DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1 0.007 1.816 4 1 4 1 407 43.4 8.56 1 1 1 1 1 1 1 1 276411.6563 228193.4219 352496.125 289383.5313 1 1 1 1 cell differentiation;cell proliferation;development;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 26528 ENSG00000071626.16 DAZAP1 19 mRNA surveillance pathway 0 High P50454 Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2 0 9.267 8 3 4 3 418 46.4 8.69 3 4 85430.71875 1288867.938 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;organelle lumen enzyme regulator activity;protein binding;RNA binding Pf00079 871 ENSG00000149257.13 SERPINH1 11 Collagen biosynthesis and modifying enzymes 0 Medium P04637 Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4 0.014 1.488 2 1 3 1 393 43.6 6.79 1 1 1 1 1 1 210218.4688 148742.0156 161798.6094 131596.5781 1 1 1 1 cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00870, Pf07710, Pf08563" 7157 ENSG00000141510.16 TP53 17 TP53 Regulates Transcription of Caspase Activators and Caspases; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Ovarian tumor domain proteases; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Factors involved in megakaryocyte development and platelet production; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Regulation of TP53 Expression; Regulation of TP53 Activity through Phosphorylation; Transcriptional activation of cell cycle inhibitor p21 ; Pre-NOTCH Transcription and Translation; The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M DNA damage checkpoint; Ub-specific processing proteases; PI5P Regulates TP53 Acetylation; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Methylation; Activation of NOXA and translocation to mitochondria; Association of TriC/CCT with target proteins during biosynthesis; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Interleukin-4 and 13 signaling; Formation of Senescence-Associated Heterochromatin Foci (SAHF); TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Oxidative Stress Induced Senescence; RUNX3 regulates CDKN1A transcription Viral carcinogenesis; Hepatitis B; Central carbon metabolism in cancer; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Epstein-Barr virus infection; Neurotrophin signaling pathway; Huntington's disease; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; Glioma; Melanoma; HTLV-I infection; Apoptosis; Wnt signaling pathway; Proteoglycans in cancer; Transcriptional misregulation in cancer; p53 signaling pathway; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS); Thyroid cancer; Hepatitis C; Cell cycle; Endocrine resistance; Basal cell carcinoma; Longevity regulating pathway; PI3K-Akt signaling pathway; Platinum drug resistance 0 High Q5BKZ1 DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2 0 4.513 4 2 3 2 582 65.6 5.15 2 1 2 1 226881.7031 272738.5 159936.8125 273700.5 1 1 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex DNA binding;metal ion binding;protein binding;RNA binding Pf04988 284695 ENSG00000162664.16 ZNF326 1 0 High Q96QK8 Small integral membrane protein 14 OS=Homo sapiens OX=9606 GN=SMIM14 PE=1 SV=1 0 5.513 20 1 3 1 99 10.7 5.29 1 1 1 2 535419.6875 200285.9844 2657262.5 1 1 1 Met-loss+Acetyl [N-Term] endoplasmic reticulum;membrane protein binding Pf11027 201895 ENSG00000163683.11 C4orf34; SMIM14 4 0 Medium Q9P2E9 Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5 0.03 1.178 1 1 3 1 1410 152.4 8.6 1 1 1 1 1 1 167294.5469 148245.5 92661.32813 1 1 1 0 High Q8NC51 Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2 0 4.817 6 2 3 2 408 44.9 8.65 2 1 2 1 342378.1563 332099.6875 253815.9219 581774.8125 1 1 1 1 Met-loss [N-Term] regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf04774 26135 ENSG00000142864.14 SERBP1 1 0 High Q9GZP9 Derlin-2 OS=Homo sapiens OX=9606 GN=DERL2 PE=1 SV=1 0 4.071 13 1 3 1 239 27.5 7.28 1 3 1184883.625 1 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;membrane catalytic activity;protein binding Pf04511 51009 ENSG00000072849.10 DERL2 17 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High P78371 T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4 0.003 2.441 4 2 3 2 535 57.5 6.46 2 1 2 1 324601.8203 278020.9453 295074.1484 397922.1719 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;organelle lumen nucleotide binding;protein binding Pf00118 10576 ENSG00000166226.12 CCT2 12 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC 0 High Q13428 Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3 0 4.188 3 3 3 3 1488 152 9.04 3 3 173259.4297 428706.7656 185396.6953 86992 2 2 2 1 cell organization and biogenesis;regulation of biological process;transport cytosol;nucleus protein binding;RNA binding;transporter activity Pf03546 6949 ENSG00000070814.17 TCOF1 5 Ribosome biogenesis in eukaryotes 0 High P35613 Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2 0 2.969 6 2 3 2 385 42.2 5.66 1 2 1 2 349770.3281 327338.9531 2 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00047, Pf07679, Pf13895, Pf13927" 682 ENSG00000172270.18 BSG 19 Integrin cell surface interactions; Proton-coupled monocarboxylate transport; Basigin interactions; Degradation of the extracellular matrix; Pyruvate metabolism 0 Medium Q92734 Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2 0.014 1.529 6 1 3 1 400 43.4 5.1 1 1 1 1 1 1 405717 561943.3125 525194.625 585104.6875 1 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane protein binding;signal transducer activity "Pf00564, Pf08232" 10342 ENSG00000114354.13 TFG 3 COPII (Coat Protein 2) Mediated Vesicle Transport Pathways in cancer; Thyroid cancer 0 High P23284 Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2 0 4.031 7 2 3 2 216 23.7 9.41 2 3 61777.05859 1275547.469 171623.6563 1 2 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 5479 ENSG00000166794.4 PPIB 15 Collagen biosynthesis and modifying enzymes 0 Medium O14654 Insulin receptor substrate 4 OS=Homo sapiens OX=9606 GN=IRS4 PE=1 SV=1 0.014 1.462 1 1 3 1 1257 133.7 8.44 1 1 1 1 1 1 232425.8906 147043.5156 211840.2969 267717.7813 1 1 1 1 regulation of biological process;response to stimulus cytosol;membrane protein binding;signal transducer activity "Pf00169, Pf02174" 8471 ENSG00000133124.11 IRS4 X IRS-related events triggered by IGF1R Longevity regulating pathway - multiple species; Insulin signaling pathway; FoxO signaling pathway; cGMP-PKG signaling pathway; Type II diabetes mellitus; AMPK signaling pathway; Regulation of lipolysis in adipocytes; Adipocytokine signaling pathway; Longevity regulating pathway 0 High P0DPK5 Histone H3.X OS=Homo sapiens OX=9606 GN=H3Y2 PE=5 SV=1 0.009 1.778 5 1 3 1 147 16.5 11.39 1 1 2 1 640050.9375 838164 1618076.125 1900967 1 1 1 1 0 High Q13049 E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2 0 2.855 4 2 3 2 653 71.9 6.98 1 1 1 1 1 1 257455.75 467621.7656 612172.1563 112636.3203 1 2 2 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00643, Pf01436, Pf10186, Pf13445, Pf13639, Pf13920, Pf13923, Pf14570, Pf14634, Pf15227" 22954 ENSG00000119401.10 TRIM32 9 Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA Ubiquitin mediated proteolysis 0 Medium Q14739 Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2 0.025 1.25 1 1 3 1 615 70.7 9.36 1 1 2 1 16310.87109 63428.92188 280223.875 203487.7188 1 1 1 1 metabolic process membrane;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf01222, Pf06966, Pf09465" 3930 ENSG00000143815.14 LBR 1 Cholesterol biosynthesis 0 High Q08554 Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2 0 5.735 3 2 3 2 894 99.9 5.43 2 1 2 1 1610499.25 555614.9688 1139896.344 1166894.094 2 2 2 2 cell death;transport cytoskeleton;membrane metal ion binding "Pf00028, Pf01049, Pf08758" 1823 ENSG00000134765.9 DSC1 18 Formation of the cornified envelope; Neutrophil degranulation 0 High Q9NVC6 Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2 0 4.235 3 2 3 2 651 72.8 7.44 2 1 2 1 217375.4844 349751.7344 257310.3047 251443.0625 2 2 2 2 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity Pf10156 9440 ENSG00000042429.11 MED17 11 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High A8MXZ3 Keratin-associated protein 9-1 OS=Homo sapiens OX=9606 GN=KRTAP9-1 PE=3 SV=1 0.002 2.308 6 1 3 1 250 26.3 7.61 1 3 468411.1406 1 Met-loss+Acetyl [N-Term] cytosol 728318 ENSG00000240542.4 KRTAP9-1 17 Keratinization 0 High Q99417 c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3 0 2.783 9 1 3 1 103 12 5.91 1 1 1 1 1 1 147433.2344 177432.5469 264568.8438 176239.2188 1 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;nucleus protein binding 26292 ENSG00000214114.8 MYCBP 1 0 Medium Q8NBP0 Tetratricopeptide repeat protein 13 OS=Homo sapiens OX=9606 GN=TTC13 PE=2 SV=3 0.025 1.235 2 1 3 1 860 96.8 7.01 1 1 1 2 376691.625 7083035.438 10492827.5 10774828.94 1 1 1 1 protein binding "Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559" 79573 ENSG00000143643.12 TTC13 1 0 Medium Q15287 RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1 0.03 1.179 2 1 3 1 305 34.2 11.84 1 1 1 1 1 1 106253.3281 234378.1094 157643.9063 113519.123 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf11608, Pf13893, Pf14259" 10921 ENSG00000205937.11 RNPS1 16 mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High P05109 Protein S100-A8 OS=Homo sapiens OX=9606 GN=S100A8 PE=1 SV=1 0 2.816 24 2 3 2 93 10.8 7.03 2 1 2 1 176061.8203 181571.1523 461611.6719 333678.5938 2 2 2 2 cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen metal ion binding;protein binding "Pf01023, Pf13499" 6279 ENSG00000143546.9 S100A8 1 Neutrophil degranulation; Metal sequestration by antimicrobial proteins; Regulation of TLR by endogenous ligand 0 High Q15437 Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2 0 5.032 3 2 3 1 767 86.4 6.89 1 2 1 2 710488.5078 918034.4063 115152.7188 1555947.719 2 2 1 2 transport cytoplasm;cytosol;endoplasmic reticulum;membrane metal ion binding;protein binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" 10483 ENSG00000101310.14 SEC23B 20 Protein processing in endoplasmic reticulum 1 High Q14978 Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2 0 7.316 4 2 3 2 699 73.6 9.47 2 3 969831.5 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus nucleotide binding;protein binding;RNA binding Pf05022 9221 ENSG00000166197.16 NOLC1 10 0 High P16615 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1 0 3.986 2 2 3 2 1042 114.7 5.34 2 1 2 1 99910.46875 549359.5313 441798.4688 1 2 2 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 488 ENSG00000174437.16 ATP2A2 12 Ion homeostasis; Pre-NOTCH Processing in Golgi; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; cGMP-PKG signaling pathway; Thyroid hormone signaling pathway; Adrenergic signaling in cardiomyocytes; Pancreatic secretion; Alzheimer's disease; Cardiac muscle contraction; cAMP signaling pathway; Calcium signaling pathway; Hypertrophic cardiomyopathy (HCM) 0 High Q13148 TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1 0.002 2.371 4 1 3 1 414 44.7 6.19 1 1 1 1 1 1 281161.2188 140765.1094 149229.9375 169943.4375 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 23435 ENSG00000120948.16 TARDBP 1 0 High Q15717 ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2 0 3.774 6 2 3 2 326 36.1 9.17 1 1 1 1 1 1 584452.0625 632882.6563 399879.8125 662982.2188 2 2 1 2 development;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 1994 ENSG00000066044.14 ELAVL1 19 HuR (ELAVL1) binds and stabilizes mRNA; mRNA Splicing - Major Pathway AMPK signaling pathway 0 High Q9P003 Protein cornichon homolog 4 OS=Homo sapiens OX=9606 GN=CNIH4 PE=1 SV=1 0 3.733 14 1 3 1 139 16.1 6.65 1 1 1 1 1 1 594018.4375 1260855.75 1 1 transport endoplasmic reticulum;membrane protein binding Pf03311 29097 ENSG00000143771.11 CNIH4 1 0 High P22234 Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3 0 3.434 7 2 3 2 425 47 7.23 1 2 1 2 308983.7422 223006.6641 220732.9844 383569.4375 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00731, Pf01259" 10606 ENSG00000128050.8 PAICS 4 Purine ribonucleoside monophosphate biosynthesis Purine metabolism; Metabolic pathways 0 High Q99848 Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2 0.009 1.775 3 1 3 1 306 34.8 10.1 1 1 1 1 1 1 258180.7656 173202.7344 147353.1875 225324.0313 1 1 1 1 metabolic process nucleus protein binding;RNA binding Pf05890 10969 ENSG00000117395.12 EBNA1BP2 1 Major pathway of rRNA processing in the nucleolus and cytosol 0 High O43175 D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4 0 2.965 3 1 3 1 533 56.6 6.71 1 1 1 1 1 1 269641.3125 301130.4688 363417.8125 380367.7813 1 1 1 1 metabolic process cytosol catalytic activity;nucleotide binding "Pf00389, Pf02826" 26227 ENSG00000092621.11 PHGDH 1 Serine biosynthesis "Carbon metabolism; Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways" 0 High Q9NZI8 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2 0.003 2.444 3 2 2 2 577 63.4 9.2 2 2 527300.0156 219386.2188 642077.4844 484115.5781 2 1 2 2 cell proliferation;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf00076, Pf13014, Pf13893, Pf14259" 10642 ENSG00000159217.9 IGF2BP1 17 MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MicroRNAs in cancer 0 Medium Q9BQ67 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1 0.014 1.469 3 1 2 1 446 49.4 4.92 1 1 1 1 95478.51563 58180.59375 102741.5 106934.3594 1 1 1 1 cell organization and biogenesis;metabolic process chromosome;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00400, Pf12265" 83743 ENSG00000105447.12 GRWD1 19 0 Medium P49336 Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1 0.043 1.117 2 1 2 1 464 53.3 8.57 1 1 1 1 79542.38281 132923.4688 121833 91398.20313 1 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1024 ENSG00000132964.11 CDK8 13 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression 0 Medium Q92917 G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2 0.043 1.106 1 1 2 1 476 52.2 6.15 1 1 1 1 1058141.875 1045621.625 992215.75 805638.25 1 1 1 1 metabolic process nucleus protein binding "Pf00467, Pf01585, Pf12656" 27238 ENSG00000068394.10 GPKOW X mRNA Splicing - Major Pathway 0 High P62308 Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1 0 5.175 17 1 2 1 76 8.5 8.88 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding;structural molecule activity "Pf01423, Pf03122" 6637 ENSG00000143977.13 SNRPG 2 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 Medium P62854 40S ribosomal protein S26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3 0.011 1.746 8 1 2 1 115 13 11 1 1 1 1 1656094.375 1493766.875 2296989.75 2458797.25 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01283 6231; 101929876; 728937 ENSG00000197728.9 RPS26; LOC101929876; RPS26P25 12; 20; 4 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P10321 "HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" 0 4.129 10 2 2 2 366 40.6 6.04 2 2 887462.75 954017.8125 678469.9375 2 2 2 regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;Golgi;membrane protein binding "Pf00129, Pf07654" 3107 ENSG00000204525.16 HLA-C 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation 0 High P02452 Collagen alpha-1(I) chain OS=Homo sapiens OX=9606 GN=COL1A1 PE=1 SV=5 0 2.942 1 2 2 2 1464 138.9 5.8 2 2 981679.2969 338443.3438 2 1 cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi;organelle lumen metal ion binding;protein binding;structural molecule activity "Pf00093, Pf01391, Pf01410" 1277 COL1A1 17 Collagen degradation; Integrin cell surface interactions; MET activates PTK2 signaling; Crosslinking of collagen fibrils; Anchoring fibril formation; Platelet Adhesion to exposed collagen; Scavenging by Class A Receptors; Syndecan interactions; GP1b-IX-V activation signalling; ECM proteoglycans; RUNX2 regulates osteoblast differentiation; Platelet Aggregation (Plug Formation); Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen chain trimerization; GPVI-mediated activation cascade; Cell surface interactions at the vascular wall Amoebiasis; Protein digestion and absorption; AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; ECM-receptor interaction; PI3K-Akt signaling pathway; Platelet activation 0 High Q9BSG0 Protease-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRADC1 PE=1 SV=1 0 3.16 10 2 2 2 188 21 5.47 2 2 46192.43359 663828.3594 1 2 extracellular protein binding Pf02225 84279 ENSG00000135617.3 PRADC1 2 0 Medium Q14683 Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2 0.049 1.063 1 1 2 1 1233 143.1 7.64 1 1 1 1 2161436.25 1475232.875 1522803.625 1406719.375 1 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus nucleotide binding;protein binding;RNA binding "Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558" 8243 ENSG00000072501.17 SMC1A X Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 Medium P05204 Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3 0.014 1.398 11 1 2 1 90 9.4 9.99 1 1 1 1 175154.7813 103865.7344 53580.41797 1 1 1 chromosome;cytoplasm;nucleus DNA binding;protein binding;RNA binding 3151 ENSG00000198830.10 HMGN2 1 0 High Q96I24 Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2 0 4.45 4 2 2 2 572 61.6 8.38 2 2 343105.2266 317349.9453 306999.5625 442162.5781 2 2 2 2 metabolic process;regulation of biological process cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf07650, Pf13014" 8939 ENSG00000107164.15 FUBP3 9 0 Medium P84243 Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3A PE=1 SV=2 0.013 1.7 5 1 2 1 136 15.3 11.27 1 1 1 1 640050.9375 838164 1618076.125 1900967 1 1 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;coagulation;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;nucleus DNA binding;protein binding "Pf00125, Pf15630" 3020; 440926; 3021 ENSG00000132475.10; ENSG00000163041.9 H3F3A; H3F3AP4; H3F3B 1; 2; 17 SIRT1 negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening Transcriptional misregulation in cancer; Systemic lupus erythematosus; Alcoholism 0 High Q96FJ2 "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" 0 4.148 12 1 2 1 89 10.3 7.37 1 1 1 1 324020.1563 710018.8125 403161.9375 1 1 1 cell communication;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding Pf01221 140735 ENSG00000264364.2 DYNLL2 17 COPI-independent Golgi-to-ER retrograde traffic; Activation of BMF and translocation to mitochondria; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Macroautophagy Vasopressin-regulated water reabsorption 0 High P54577 "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" 0 3.257 3 2 2 2 528 59.1 7.05 2 2 235832.3438 38550.70703 1 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding;RNA binding;signal transducer activity "Pf00579, Pf01588" 8565 ENSG00000134684.10 YARS 1 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 Medium Q15417 Calponin-3 OS=Homo sapiens OX=9606 GN=CNN3 PE=1 SV=1 0.014 1.409 3 1 2 1 329 36.4 6.05 1 1 1 1 178012.2813 159250.4219 169195.6094 197968.6094 1 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process cytoskeleton;cytosol protein binding "Pf00307, Pf00402" 1266 ENSG00000117519.15 CNN3 1 0 High P04844 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3 0 6.122 5 2 2 2 631 69.2 5.69 2 2 563215.375 1 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;protein binding Pf05817 6185 ENSG00000118705.16 RPN2 20 Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 Medium P46977 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens OX=9606 GN=STT3A PE=1 SV=2 0.014 1.479 1 1 2 1 705 80.5 8.07 1 1 1 1 10889.66797 26016.35352 119526.4531 115612.0078 1 1 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf02516 3703 ENSG00000134910.12 STT3A 11 Asparagine N-linked glycosylation N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High P25398 40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3 0 4.896 25 2 2 2 132 14.5 7.21 1 1 1 1 385392.1563 283932.1719 482391.0938 483448.75 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01248 6206 ENSG00000112306.7 RPS12 6 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 Medium P09496 Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1 0.015 1.574 3 1 2 1 248 27.1 4.51 1 1 1 1 217240.7188 286852.9375 266752.25 182699.9688 1 1 1 1 cell division;cell organization and biogenesis;cellular component movement;metabolic process;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity Pf01086 1211 ENSG00000122705.16 CLTA 9 "Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle 0 High P10515 "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" 0 3.574 7 2 2 2 647 69 7.84 2 2 447470.6719 2 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 1737 ENSG00000150768.15 DLAT 11 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High Q8TCT9 Minor histocompatibility antigen H13 OS=Homo sapiens OX=9606 GN=HM13 PE=1 SV=1 0 5.668 10 2 2 2 377 41.5 6.43 2 2 199453.2344 1711749.875 1 1 cell organization and biogenesis;metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity;protein binding "Pf04258, Pf06550" 81502 ENSG00000101294.16 HM13 20 0 Medium P30049 "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" 0.02 1.324 8 1 2 1 168 17.5 5.49 1 1 1 1 170610.5313 196881.7969 1 1 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;transporter activity Pf02823 513 ENSG00000099624.7 ATP5D 19 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High P14618 Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4 0.003 2.515 2 1 2 1 531 57.9 7.84 1 1 1 1 154692.2031 196511.4844 232311.4063 1 1 1 cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00224, Pf02887" 5315 ENSG00000067225.17 PKM 15 Glycolysis; Neutrophil degranulation Viral carcinogenesis; Central carbon metabolism in cancer; Carbon metabolism; Purine metabolism; Pyruvate metabolism; Type II diabetes mellitus; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 Medium P05089 Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2 0.015 1.64 3 1 2 1 322 34.7 7.21 1 1 1 1 172321.6094 64573.51172 141680.7344 136504.2813 1 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;metal ion binding Pf00491 383 ENSG00000118520.14 ARG1 6 Urea cycle; Neutrophil degranulation Arginine biosynthesis; Amoebiasis; Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High P61619 Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens OX=9606 GN=SEC61A1 PE=1 SV=2 0.005 2.023 2 1 2 1 476 52.2 8.06 1 1 1 1 56887.69531 184513.0938 1 1 cell growth;cell organization and biogenesis;response to stimulus;transport cytosol;endoplasmic reticulum;membrane protein binding "Pf00344, Pf10559" 29927 ENSG00000058262.9 SEC61A1 3 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 Medium P62304 Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1 0.03 1.205 12 1 2 1 92 10.8 9.44 1 1 1 1 360504.5313 1780301.5 2365057 2671865.5 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6635 ENSG00000182004.12 SNRPE 1 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 High Q96P63 Serpin B12 OS=Homo sapiens OX=9606 GN=SERPINB12 PE=1 SV=1 0.005 1.966 2 1 2 1 405 46.2 5.53 1 1 1 1 228239.4531 88653.91406 225224.875 154918.6875 1 1 1 1 cell differentiation;regulation of biological process;transport cytoplasm;membrane enzyme regulator activity;protein binding Pf00079 89777 ENSG00000166634.6 SERPINB12 18 Neutrophil degranulation 0 High Q13472 DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1 0 3.458 2 2 2 2 1001 112.3 8.34 2 2 80049.99219 538455.5703 182679.5 263336.5547 1 2 2 2 metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf01131, Pf01396, Pf01751, Pf06839" 7156 ENSG00000177302.14; ENSG00000284238.1 TOP3A 17; CHR_HSCHR17_3_CTG1 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 Medium P49368 T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4 0.044 1.121 3 1 2 1 545 60.5 6.49 1 1 1 1 123646.3828 100753.6406 155308 119410.9609 1 1 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane nucleotide binding;protein binding;RNA binding Pf00118 7203 ENSG00000163468.14 CCT3 1 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q96E52 "Metalloendopeptidase OMA1, mitochondrial OS=Homo sapiens OX=9606 GN=OMA1 PE=1 SV=1" 0.003 2.53 4 2 2 2 524 60.1 9.25 2 2 577138.7578 713836.0938 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;metal ion binding Pf01435 115209 ENSG00000162600.11 OMA1 1 Regulation of Apoptosis 0 High P36957 "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" 0 2.747 3 1 2 1 453 48.7 8.95 1 2 545511.875 1 metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity "Pf00198, Pf00364" 1743 ENSG00000119689.14 DLST 14 Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Lysine degradation; Metabolic pathways 0 High Q9UN86 Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2 0 5.472 5 2 2 2 482 54.1 5.55 2 2 147126.875 111215.125 639868.7813 111647.6094 1 1 2 1 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol protein binding;RNA binding;structural molecule activity "Pf00076, Pf02136, Pf14259" 9908 ENSG00000138757.14 G3BP2 4 0 Medium Q9H853 Putative tubulin-like protein alpha-4B OS=Homo sapiens OX=9606 GN=TUBA4B PE=5 SV=2 0.015 1.529 5 1 2 1 241 27.5 7.83 1 2 187607.2344 131039.6484 235778.4375 203785.8438 1 1 1 1 cell organization and biogenesis cytoplasm;cytoskeleton catalytic activity;nucleotide binding;structural molecule activity Pf00091 80086 ENSG00000243910.7 TUBA4B 2 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Cilium Assembly; Recruitment of NuMA to mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation 0 High Q15046 Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3 0.007 1.852 2 1 2 1 597 68 6.35 1 1 1 1 389558.75 457283.1563 492632.3438 301709.625 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf00587, Pf01336" 3735 ENSG00000065427.14 KARS 16 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High O95831 "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" 0.002 2.278 2 1 2 1 613 66.9 8.95 1 2 362838.25 128687.5078 146407.4219 151362.9844 1 1 1 1 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00070, Pf07992, Pf14721, Pf14962" 9131 ENSG00000156709.13 AIFM1 X Apoptosis 0 Medium P61927 60S ribosomal protein L37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2 0.011 1.714 10 1 2 1 97 11.1 11.74 1 1 1 1 2063174.875 1857252.125 1715393.875 2294615.5 1 1 1 1 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome metal ion binding;RNA binding;structural molecule activity Pf01907 6167 ENSG00000145592.13 RPL37 5 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O75147 Obscurin-like protein 1 OS=Homo sapiens OX=9606 GN=OBSL1 PE=1 SV=4 0 3.512 1 2 2 2 1896 206.8 5.63 2 2 287955.375 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;Golgi protein binding;structural molecule activity "Pf00041, Pf00047, Pf01108, Pf07679, Pf07686, Pf13895, Pf13927" 23363 ENSG00000124006.14 OBSL1 2 Neddylation 0 High Q92896 Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2 0 6.06 2 2 2 2 1179 134.5 6.9 2 2 21631.62109 164161.5781 88532.80469 1 1 1 cellular component movement;regulation of biological process Golgi;membrane protein binding Pf00839 2734 ENSG00000090863.11 GLG1 16 Cell surface interactions at the vascular wall Cell adhesion molecules (CAMs) 0 High P31040 "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" 0 2.918 3 2 2 2 664 72.6 7.39 2 2 184916.9648 114248.7109 123236.2578 269546.6719 2 1 1 2 metabolic process;transport membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00890, Pf02910" 6389 ENSG00000073578.16 SDHA 5 Respiratory electron transport; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q14444 Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2 0.002 2.311 2 1 2 1 709 78.3 5.25 1 1 1 1 358340.9063 207579.5938 410875.4063 364737.9063 1 1 1 1 cell differentiation;regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf12287 4076 ENSG00000135387.20 CAPRIN1 11 0 High P60468 Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2 0.002 2.067 10 1 2 1 96 10 11.56 1 1 1 1 119260.375 148818.4063 161260.5625 222626.7656 1 1 1 1 metabolic process;transport cytosol;endoplasmic reticulum;membrane protein binding;RNA binding;transporter activity Pf03911 10952 ENSG00000106803.9 SEC61B 9 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 Medium Q9BY77 Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2 0.021 1.298 3 1 2 1 421 46.1 9.99 1 2 113266.4609 114452.4063 406343.2188 155662.9063 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 84271 ENSG00000100227.17 POLDIP3 22 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High Q8IWX8 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3 0 3.522 3 2 2 2 916 103.6 9.04 1 1 1 1 100367.0078 278391.6641 361078.6563 187098.5781 1 2 2 1 cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;membrane protein binding;RNA binding "Pf01585, Pf01805, Pf04818" 10523 ENSG00000085872.14 CHERP 19 mRNA Splicing - Major Pathway Spliceosome 0 High P49327 Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3 0.002 2.218 1 2 2 2 2511 273.3 6.44 1 1 1 1 Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf00107, Pf00108, Pf00109, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf13602, Pf14765" 2194 ENSG00000169710.8 FASN 17 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism; Activation of gene expression by SREBF (SREBP) Insulin signaling pathway; Fatty acid biosynthesis; AMPK signaling pathway; Metabolic pathways; Fatty acid metabolism 0 High Q9UDY2 Tight junction protein ZO-2 OS=Homo sapiens OX=9606 GN=TJP2 PE=1 SV=2 0.003 2.453 2 2 2 2 1190 133.9 7.4 2 2 181630.6406 427453.9453 71556.89063 2 2 1 metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane;nucleus catalytic activity;protein binding "Pf00595, Pf00625, Pf07653, Pf13180" 9414 ENSG00000119139.17 TJP2 9 Apoptotic cleavage of cell adhesion proteins; Signaling by Hippo Tight junction; Vibrio cholerae infection 0 High P51659 Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3 0.002 2.228 2 1 2 1 736 79.6 8.84 1 1 1 1 227178.8281 179453.9844 391756.4375 164746.1875 1 1 1 1 cell differentiation;metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf00106, Pf01575, Pf02036, Pf08659, Pf13452, Pf13561, Pf14864" 3295 ENSG00000133835.14 HSD17B4 5 Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids Peroxisome; Metabolic pathways; Primary bile acid biosynthesis 0 Medium P26599 Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1 0.015 1.542 2 1 2 1 531 57.2 9.17 1 1 1 1 779064.75 743345.75 581566.9375 673154.75 1 1 1 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 5725 ENSG00000011304.19 PTBP1 19 mRNA Splicing - Major Pathway; FGFR2 alternative splicing 0 High Q9UHX1 Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1 0 3.739 8 2 2 2 559 59.8 5.29 2 2 153808.6719 813123.8125 133167.4844 76730.33594 1 2 1 1 cell death;cellular homeostasis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22827 ENSG00000274081.4; ENSG00000179950.13 PUF60 8; CHR_HSCHR8_3_CTG7 mRNA Splicing - Major Pathway Spliceosome 0 High Q53HI1 Protein unc-50 homolog OS=Homo sapiens OX=9606 GN=UNC50 PE=1 SV=2 0 4.114 8 1 2 1 259 30.4 9.47 1 2 92773.19531 1 Acetyl [N-Term] transport Golgi;membrane;nucleus RNA binding Pf05216 25972 ENSG00000115446.11 UNC50 2 0 High Q99942 E3 ubiquitin-protein ligase RNF5 OS=Homo sapiens OX=9606 GN=RNF5 PE=1 SV=1 0 3.84 9 1 2 1 180 19.9 6.65 1 1 1 1 384894.3438 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00097, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" 6048 ENSG00000228405.5; ENSG00000228907.5; ENSG00000183574.12; ENSG00000204308.7; ENSG00000227277.9; ENSG00000225452.5; ENSG00000223767.5 RNF5 6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_APD_CTG1 ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis Protein processing in endoplasmic reticulum 0 Medium P98196 Probable phospholipid-transporting ATPase IH OS=Homo sapiens OX=9606 GN=ATP11A PE=1 SV=3 0.015 1.592 1 1 2 1 1134 129.7 6.6 1 1 1 1 1525908.625 1452384 874580.0625 944079.6875 1 1 1 1 cell organization and biogenesis;transport endoplasmic reticulum;endosome;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00702, Pf08282, Pf13206, Pf13246" 23250 ENSG00000068650.18 ATP11A 13 Neutrophil degranulation; Ion transport by P-type ATPases 0 High P09012 U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3 0.005 1.94 3 1 2 1 282 31.3 9.83 1 1 1 1 325538.8125 278396.7813 395984.25 858702.0625 1 1 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6626 ENSG00000077312.8 SNRPA 19 mRNA Splicing - Major Pathway Spliceosome 0 High Q9Y3Q8 TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2 0 3.69 6 2 2 2 395 41 7.21 1 1 1 1 1312360.625 801010.5938 988878.4375 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;reproduction cytoplasm;nucleus protein binding "Pf01166, Pf04977, Pf06005, Pf06156" 81628 ENSG00000166925.8 TSC22D4 7 0 Medium Q9UMS4 Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1 0.02 1.325 3 1 2 1 504 55.1 6.61 1 1 1 1 210066.7813 220291.3281 216316.5 238486.1406 1 1 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex catalytic activity;metal ion binding;protein binding "Pf00400, Pf04564, Pf08606, Pf11789" 27339 ENSG00000110107.8 PRPF19 11 Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Spliceosome 0 Medium O75165 DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5 0.015 1.624 1 1 2 1 2243 254.3 6.74 1 1 1 1 139272.4375 44512.91016 110005.4844 112449.4219 1 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;membrane protein binding "Pf00226, Pf14237" 23317 ENSG00000138246.15 DNAJC13 3 Neutrophil degranulation 0 Medium P26368 Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4 0.011 1.733 2 1 2 1 475 53.5 9.09 1 1 1 1 229158.2188 259795.2969 349027.5 212495.9219 1 1 1 1 metabolic process;regulation of biological process;transport nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 11338 ENSG00000063244.12 U2AF2 19 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome 0 High Q01469 Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3 0.009 1.761 7 1 2 1 135 15.2 7.01 1 1 1 1 92875.9375 135869.5156 153580.9219 1 1 1 Met-loss+Acetyl [N-Term] metabolic process;transport cytoplasm;cytosol;extracellular;membrane;organelle lumen protein binding;transporter activity Pf00061 2171 ENSG00000164687.10 FABP5 8 Triglyceride catabolism; Signaling by Retinoic Acid; Neutrophil degranulation PPAR signaling pathway 0 High P26583 High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2 0 5.389 13 2 2 1 209 24 7.81 2 2 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;extracellular;nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf09011" 3148 ENSG00000164104.11 HMGB2 4 Activation of DNA fragmentation factor 0 High O75607 Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3 0.005 1.944 10 1 2 1 178 19.3 4.63 1 1 1 1 77423.90625 76912.5 1 1 Met-loss+Acetyl [N-Term] metabolic process cytoskeleton;cytosol;nucleus protein binding;RNA binding "Pf02087, Pf03066" 10360 ENSG00000107833.10 NPM3 10 0 Medium Q13643 Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4 0.016 1.342 3 1 2 1 280 31.2 6.2 1 1 1 1 168010.3906 184341.8125 180868.8438 182585.5156 1 1 1 1 cell organization and biogenesis nucleus metal ion binding;protein binding Pf00412 2275 ENSG00000183386.9 FHL3 1 0 High P51668 Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1 0 5.812 20 2 2 1 147 16.6 7.42 2 2 50895.47266 40198.16406 292010.9063 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding "Pf00179, Pf05773" 7321 ENSG00000072401.14 UBE2D1 10 "Inactivation of APC/C via direct inhibition of the APC/C complex; Downstream TCR signaling; TICAM1, RIP1-mediated IKK complex recruitment ; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; APC-Cdc20 mediated degradation of Nek2A; Ovarian tumor domain proteases; Antigen processing: Ubiquitination & Proteasome degradation; Activated TLR4 signalling; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; APC/C:Cdc20 mediated degradation of Cyclin B; IKK complex recruitment mediated by RIP1; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FCERI mediated NF-kB activation; Neddylation; Phosphorylation of the APC/C; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Signaling by BMP; E3 ubiquitin ligases ubiquitinate target proteins; Negative regulators of DDX58/IFIH1 signaling; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP); CLEC7A (Dectin-1) signaling" Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 High Q5K4L6 Solute carrier family 27 member 3 OS=Homo sapiens OX=9606 GN=SLC27A3 PE=1 SV=4 0 3.422 4 2 2 2 683 73.5 7.09 2 2 1699806.25 201642.875 378812.8438 673171.0313 1 1 1 2 metabolic process catalytic activity "Pf00501, Pf13193" 0 High Q5D862 Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1 0 3.947 1 1 2 1 2391 247.9 8.31 1 1 1 1 718460.25 310687.4063 682260.25 512004.1875 1 1 1 1 transport cytoplasm;extracellular;nucleus metal ion binding;structural molecule activity 388698 ENSG00000143520.6 FLG2 1 Neutrophil degranulation 0 High P60059 Protein transport protein Sec61 subunit gamma OS=Homo sapiens OX=9606 GN=SEC61G PE=1 SV=1 0 3.378 18 1 2 1 68 7.7 9.99 1 1 1 1 37166.05078 68832.36719 96745.78906 158942.2188 1 1 1 1 Acetyl [N-Term] transport cytosol;endoplasmic reticulum;membrane protein binding;transporter activity Pf00584 23480 ENSG00000132432.13 SEC61G 7 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 High O15258 Protein RER1 OS=Homo sapiens OX=9606 GN=RER1 PE=1 SV=1 0.007 1.841 10 1 1 1 196 22.9 9.54 1 1 28370.76367 60731.75781 95248.07031 217881.625 1 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport cell surface;Golgi;membrane protein binding Pf03248 11079 ENSG00000157916.19 RER1 1 0 Medium O15235 "28S ribosomal protein S12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" 0.043 1.09 7 1 1 1 138 15.2 10.29 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00164 6183 ENSG00000283018.1; ENSG00000128626.11 MRPS12 19; CHR_HG26_PATCH Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Medium Q53H12 "Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2" 0.015 1.611 3 1 1 1 422 47.1 8.09 1 1 84002.07813 60456.78906 100686.1563 126852.8047 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding Pf00781 55750 ENSG00000006530.15 AGK 7 Signaling by BRAF and RAF fusions; Glycerophospholipid biosynthesis Glycerolipid metabolism; Metabolic pathways 0 Medium Q9NZ01 Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1 0.013 1.686 3 1 1 1 308 36 9.45 1 1 208446.3125 1035675.875 826145.0625 1 1 1 metabolic process cytoplasm;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding Pf02544 9524 ENSG00000099797.13 TECR 19 Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 Medium Q9NRP0 Oligosaccharyltransferase complex subunit OSTC OS=Homo sapiens OX=9606 GN=OSTC PE=1 SV=1 0.011 1.741 8 1 1 1 149 16.8 9.13 1 1 848305.375 801750.1875 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf04756 58505 ENSG00000198856.12 OSTC 4 0 Medium Q7L014 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2 0.039 1.141 1 1 1 1 1031 117.3 9.29 1 1 277949.6563 138451.125 133418.9844 1 1 1 metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271" 9879 ENSG00000145833.15 DDX46 5 mRNA Splicing - Major Pathway Spliceosome 0 High O95295 SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1 0.005 2.007 16 1 1 1 136 14.9 9.31 1 1 Met-loss+Acetyl [N-Term] cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;vacuole protein binding Pf14712 23557 ENSG00000143553.10 SNAPIN 1 Golgi Associated Vesicle Biogenesis 0 Medium Q5SNT2 Transmembrane protein 201 OS=Homo sapiens OX=9606 GN=TMEM201 PE=1 SV=1 0.03 1.199 2 1 1 1 666 72.2 9.22 1 1 47481.31641 189545.1563 1 1 cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton;membrane;nucleus protein binding "Pf09779, Pf10476" 199953 ENSG00000188807.12 TMEM201 1 0 Medium O60244 Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2 0.03 1.182 1 1 1 1 1454 160.5 8.73 1 1 75288.125 111309.3438 82044.65625 85179.58594 1 1 1 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity "Pf08638, Pf15449" 9282 ENSG00000180182.10 MED14 X Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 Medium O15042 U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2 0.025 1.252 1 1 1 1 1029 118.2 8.47 1 1 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf01805, Pf08312, Pf13893, Pf14259" 23350 ENSG00000163714.17 U2SURP 3 mRNA Splicing - Major Pathway Spliceosome 0 Medium P07203 Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4 0.023 1.272 6 1 1 1 203 22.1 6.55 1 1 146194.7344 188936.7031 170659.2813 1 1 1 cell death;cell differentiation;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;organelle lumen antioxidant activity;catalytic activity;protein binding Pf00255 2876 ENSG00000233276.3 GPX1 3 Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives; Detoxification of Reactive Oxygen Species; Synthesis of 5-eicosatetraenoic acids; Purine catabolism Glutathione metabolism; Huntington's disease; Arachidonic acid metabolism; Thyroid hormone synthesis; Amyotrophic lateral sclerosis (ALS) 0 Medium Q05048 Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1 0.013 1.702 3 1 1 1 431 48.3 6.58 1 1 88480.92188 31821.97852 1 1 metabolic process nucleus protein binding;RNA binding "Pf00400, Pf11768" 1477 ENSG00000101138.11 CSTF1 20 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High Q8TAV4 Stomatin-like protein 3 OS=Homo sapiens OX=9606 GN=STOML3 PE=1 SV=1 0.005 2.008 2 1 1 1 291 32.1 8.63 1 1 146032.2969 1 regulation of biological process;response to stimulus;transport membrane Pf01145 161003 ENSG00000133115.11 STOML3 13 Stimuli-sensing channels 0 High O75439 Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2 0.005 1.961 2 1 1 1 489 54.3 6.83 1 1 117896.1172 100251.7344 122374.6719 124633.8828 1 1 1 1 metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf00675, Pf05193" 9512 ENSG00000105819.13 PMPCB 7 Processing of SMDT1; Mitochondrial protein import; Metabolism of proteins 0 Medium Q7Z4W1 L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2 0.026 1.224 3 1 1 1 244 25.9 8.1 1 1 147022.9219 145160.3281 99469.125 162644.5 1 1 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process membrane;nucleus catalytic activity;protein binding "Pf00106, Pf01488, Pf08659, Pf13460, Pf13561" 51181 ENSG00000169738.7 DCXR 17 Catabolism of glucuronate to xylulose-5-phosphate; Essential pentosuria Pentose and glucuronate interconversions; Metabolic pathways 0 Medium Q8TA86 Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2 0.011 1.741 5 1 1 1 221 26.1 9.79 1 1 198458.7344 548898.5 337148.5625 277480.0313 1 1 1 1 metabolic process cytosol;nucleus metal ion binding;protein binding;RNA binding 6100 ENSG00000164610.8 RP9 7 Spliceosome 0 High O95685 Protein phosphatase 1 regulatory subunit 3D OS=Homo sapiens OX=9606 GN=PPP1R3D PE=1 SV=1 0.007 1.883 4 1 1 1 299 32.5 8.07 1 1 453184.5938 1 metabolic process;regulation of biological process catalytic activity;protein binding Pf03370 5509 ENSG00000132825.6 PPP1R3D 20 Insulin signaling pathway; Insulin resistance 0 High P13929 Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5 0.002 2.189 3 1 1 1 434 47 7.71 1 1 390325.875 359243.0313 289521.8125 1 1 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;metal ion binding "Pf00113, Pf03952, Pf13378" 2027 ENSG00000108515.17 ENO3 17 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Glycolysis / Gluconeogenesis; RNA degradation; Biosynthesis of amino acids; Metabolic pathways 0 High Q96FZ2 Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1 0.007 1.838 4 1 1 1 354 40.5 8.15 1 1 524364.625 640739.3125 488739.8438 1 1 1 metabolic process catalytic activity;DNA binding Pf02586 56941 ENSG00000183624.13 C3orf37; HMCES 3 0 Medium Q8TAD4 Zinc transporter 5 OS=Homo sapiens OX=9606 GN=SLC30A5 PE=1 SV=1 0.026 1.225 1 1 1 1 765 84 7.31 1 1 109554.9609 196555.6875 1 1 cellular homeostasis;regulation of biological process;response to stimulus;transport Golgi;membrane;nucleus metal ion binding;transporter activity Pf01545 64924 ENSG00000145740.18 SLC30A5 5 Insulin processing; Zinc efflux and compartmentalization by the SLC30 family 0 Medium Q16629 Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1 0.015 1.542 4 1 1 1 238 27.4 11.82 1 1 265790.9375 128790.3438 247013.3281 184389.5 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6432 ENSG00000115875.18 SRSF7 2 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 Medium Q53H96 Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3 0.027 1.225 4 1 1 1 274 28.6 7.72 1 1 273717.5 1 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf03807, Pf14748" 65263 ENSG00000276657.2; ENSG00000104524.13 PYCRL; PYCR3 8; CHR_HSCHR8_3_CTG7 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 Medium P57088 Transmembrane protein 33 OS=Homo sapiens OX=9606 GN=TMEM33 PE=1 SV=2 0.014 1.417 4 1 1 1 247 28 9.7 1 1 65942.46875 111121.0859 224067.2656 221658.4844 1 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;nucleus protein binding;structural molecule activity Pf03661 55161 ENSG00000109133.12 TMEM33 4 0 High P0CG08 Golgi pH regulator B OS=Homo sapiens OX=9606 GN=GPR89B PE=1 SV=1 0 3.782 2 1 1 1 455 52.9 9.28 1 1 152222.2188 341121.7188 1 1 cellular homeostasis;regulation of biological process;response to stimulus;transport Golgi;membrane signal transducer activity;transporter activity "Pf12430, Pf12537" 653519; 51463 ENSG00000188092.14; ENSG00000117262.18 GPR89A; GPR89B 1 0 Medium Q99538 Legumain OS=Homo sapiens OX=9606 GN=LGMN PE=1 SV=1 0.042 1.13 4 1 1 1 433 49.4 6.55 1 1 251423.9375 1 metabolic process;regulation of biological process;response to stimulus endosome;organelle lumen;vacuole catalytic activity Pf01650 5641 ENSG00000100600.14 LGMN 14 Vitamin D (calciferol) metabolism; MHC class II antigen presentation; Trafficking and processing of endosomal TLR Lysosome; Antigen processing and presentation 0 High Q14145 Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2 0 2.651 2 1 1 1 624 69.6 6.44 1 1 148742.2188 327867.5938 694560.375 209179.1094 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964" 9817 ENSG00000079999.13 KEAP1 19 Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High Q5VZ66 Janus kinase and microtubule-interacting protein 3 OS=Homo sapiens OX=9606 GN=JAKMIP3 PE=2 SV=2 0.005 1.9 3 1 1 1 844 98.5 5.66 1 1 22764246 65828832 46474868 25097502 1 1 1 1 metabolic process Golgi protein binding Pf04111 282973 ENSG00000188385.11 JAKMIP3 10 0 High Q15532 Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3 0.003 2.388 4 1 1 1 418 45.9 6.46 1 1 297916.875 571450.75 284891.3438 440749.625 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding Pf05030 6760 ENSG00000141380.13 SS18 18 Transcriptional misregulation in cancer 0 Medium P49458 Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2 0.015 1.535 9 1 1 1 86 10.1 7.97 1 1 260255.6719 355210.5938 319129.0313 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol protein binding;RNA binding Pf05486 6726; 653226 ENSG00000143742.12 SRP9; SRP9P1 1; 10 SRP-dependent cotranslational protein targeting to membrane Protein export 0 Medium O75533 Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3 0.015 1.629 1 1 1 1 1304 145.7 7.09 1 1 78678.38281 113856.7734 135845.7344 139756.2188 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity "Pf02161, Pf08920, Pf12815, Pf13513" 23451 ENSG00000115524.15 SF3B1 2 B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 Medium P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1 0.015 1.663 4 1 1 1 330 37.5 6.33 1 1 107776.9063 86765.32813 95776.01563 74374.25 1 1 1 1 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf00149 5499 ENSG00000172531.14 PPP1CA 11 Signaling by GPCR; Triglyceride catabolism; DARPP-32 events; Downregulation of TGF-beta receptor signaling; Circadian Clock Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation 0 Medium P40926 "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" 0.043 1.081 3 1 1 1 338 35.5 8.68 1 1 63790.98047 45136.42969 187245.75 1 1 1 metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00056, Pf01073, Pf01118, Pf02866, Pf13460" 4191 ENSG00000146701.11 MDH2 7 Gluconeogenesis; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Metabolic pathways; Cysteine and methionine metabolism; Glyoxylate and dicarboxylate metabolism 0 Medium Q93009 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2 0.011 1.708 1 1 1 1 1102 128.2 5.55 1 1 130699.5078 101488.0859 166886.9531 1 1 1 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00443, Pf00917, Pf12436, Pf13423, Pf14533" 7874 ENSG00000187555.14 USP7 16 Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization Viral carcinogenesis; FoxO signaling pathway; Epstein-Barr virus infection; Herpes simplex infection 0 Medium O43150 "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ASAP2 PE=1 SV=3" 0.014 1.477 1 1 1 1 1006 111.6 6.68 1 1 127459048 24896656 119190632 77539128 1 1 1 1 regulation of biological process cytoplasm;Golgi;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00018, Pf00023, Pf00169, Pf01412, Pf07653, Pf12796, Pf13637, Pf13857, Pf14604" 8853 ENSG00000151693.9 ASAP2 2 Endocytosis; Fc gamma R-mediated phagocytosis 0 Medium Q14011 Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1 0.044 1.124 5 1 1 1 172 18.6 9.51 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding;RNA binding;translation regulator activity "Pf00076, Pf13893, Pf14259" 1153 ENSG00000099622.13 CIRBP 19 0 Medium Q8IXS6 Paralemmin-2 OS=Homo sapiens OX=9606 GN=PALM2 PE=1 SV=3 0.043 1.089 2 1 1 1 379 42.2 5.1 1 1 4483213 4108806.5 8954096 4625202.5 1 1 1 1 regulation of biological process membrane Pf03285 114299 ENSG00000243444.7 PALM2 9 0 High Q66PJ3 ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=2 0.002 2.064 5 1 1 1 421 44.9 10.93 1 1 290959.2813 1 metabolic process nucleus protein binding;RNA binding Pf10500 51329 ENSG00000182196.13 ARL6IP4 12 0 High Q8ND56 Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3 0.007 1.85 3 1 1 1 463 50.5 9.52 1 1 97024.10156 139624.1406 391156.8438 125649.1875 1 1 1 1 cell organization and biogenesis;defense response;development;regulation of biological process;response to stimulus cytoplasm;cytosol DNA binding;RNA binding "Pf09532, Pf12701, Pf14438" 26065 ENSG00000262860.5; ENSG00000257103.8 LSM14A 19; CHR_HSCHR19_1_CTG3_1 0 Medium Q8TDI8 Transmembrane channel-like protein 1 OS=Homo sapiens OX=9606 GN=TMC1 PE=1 SV=2 0.011 1.716 4 1 1 1 760 87.7 6.52 1 1 regulation of biological process;response to stimulus;transport membrane transporter activity Pf07810 117531 ENSG00000165091.15 TMC1 9 0 Medium Q9P0T7 Transmembrane protein 9 OS=Homo sapiens OX=9606 GN=TMEM9 PE=1 SV=1 0.044 1.122 4 1 1 1 183 20.6 6.65 1 1 1121670.5 1 transport endosome;membrane;vacuole Pf05434 252839 ENSG00000116857.16 TMEM9 1 0 Medium P29692 Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5 0.028 1.218 4 1 1 1 281 31.1 5.01 1 1 158913.375 107465.2969 107349.125 289475.6875 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus DNA binding;protein binding;RNA binding;signal transducer activity "Pf00736, Pf10587" 1936 ENSG00000104529.17; ENSG00000273594.4 EEF1D 8; CHR_HSCHR8_3_CTG7 Eukaryotic Translation Elongation Herpes simplex infection 0 High Q7Z2K8 G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2 0.002 2.292 2 1 1 1 1008 102.3 8.06 1 1 147582.875 136050.0313 315613.7188 1 1 1 cell organization and biogenesis membrane protein binding Pf15235 114787 ENSG00000169258.6 GPRIN1 5 0 Medium Q99832 T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2 0.043 1.088 1 1 1 1 543 59.3 7.65 1 1 96043.28906 103857.5781 125050.2969 131327.8438 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;mitochondrion nucleotide binding;protein binding Pf00118 10574 ENSG00000135624.15 CCT7 2 Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 Medium Q9Y230 RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3 0.035 1.167 3 1 1 1 463 51.1 5.64 1 1 152627.0469 108577.9453 119053.7656 114617.3984 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03796, Pf06068, Pf13481" 10856 ENSG00000183207.13 RUVBL2 19 HATs acetylate histones; Telomere Extension By Telomerase 0 Medium Q96JN8 Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2 0.03 1.181 1 1 1 1 1562 166.8 5.86 1 1 cytoplasm;cytoskeleton protein binding Pf07177 84461 ENSG00000215041.9 NEURL4 17 0 Medium P18031 Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1 0.014 1.446 1 1 1 1 435 49.9 6.27 1 1 99655.94531 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane catalytic activity;metal ion binding;protein binding;RNA binding "Pf00102, Pf00782" 5770 ENSG00000196396.9 PTPN1 20 Regulation of IFNA signaling; Negative regulation of MET activity; Regulation of IFNG signaling; PTK6 Down-Regulation; Integrin alphaIIb beta3 signaling; Growth hormone receptor signaling Insulin signaling pathway; Adherens junction; Insulin resistance 0 Medium P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4 0.021 1.285 2 1 1 1 456 50.8 6.55 1 1 85781.88281 390749.6875 351911.3438 1 1 1 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;protein binding Pf03345 1650 ENSG00000244038.9 DDOST 1 Advanced glycosylation endproduct receptor signaling; Asparagine N-linked glycosylation; Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q8IZ83 Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2 0.002 2.249 3 1 1 1 802 85.1 6.79 1 1 294547.7188 1 metabolic process membrane catalytic activity "Pf00171, Pf07368" 126133 ENSG00000161618.9 ALDH16A1 19 0 High Q16531 DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1 0 2.676 1 1 1 1 1140 126.9 5.26 1 1 489641.8438 310294.3438 389472.8125 495799.5313 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding "Pf03178, Pf10433" 1642 ENSG00000167986.13 DDB1 11 Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation Viral carcinogenesis; Hepatitis B; Ubiquitin mediated proteolysis; Nucleotide excision repair 0 High O00483 Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1 0.002 2.36 12 1 1 1 81 9.4 9.38 1 1 301370 264570.9375 515791.5938 598463.6875 1 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf06522 4697 ENSG00000189043.9 NDUFA4 7 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q15043 Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3 0.005 1.902 2 1 1 1 492 54.2 5.33 1 1 94578.36719 63788.54297 1 1 cellular homeostasis;transport cytoplasm;membrane transporter activity Pf02535 23516 ENSG00000104635.13 SLC39A14 8 Zinc influx into cells by the SLC39 gene family 0 Medium Q9Y2X3 Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1 0.043 1.113 3 1 1 1 529 59.5 8.92 1 1 53922.61328 68787.14063 36012.91406 139820.5156 1 1 1 1 cell growth;metabolic process cytosol;membrane;nucleus protein binding;RNA binding "Pf01798, Pf08060, Pf08156" 51602 ENSG00000055044.10 NOP58 2 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SUMOylation of RNA binding proteins Ribosome biogenesis in eukaryotes 0 Medium Q15758 Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2 0.039 1.159 4 1 1 1 541 56.6 5.48 1 1 transport membrane protein binding;receptor activity;transporter activity Pf00375 6510 ENSG00000105281.12 SLC1A5 19 Amino acid transport across the plasma membrane Central carbon metabolism in cancer; Protein digestion and absorption 0 Medium Q8N163 Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2 0.015 1.561 2 1 1 1 923 102.8 5.22 1 1 103412.7344 17972.66016 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;organelle lumen;spliceosomal complex enzyme regulator activity;protein binding;RNA binding "Pf14443, Pf14444" 57805 ENSG00000158941.16 CCAR2; KIAA1967 8 Regulation of HSF1-mediated heat shock response 0 Medium Q9NVH6 "Trimethyllysine dioxygenase, mitochondrial OS=Homo sapiens OX=9606 GN=TMLHE PE=1 SV=1" 0.023 1.27 3 1 1 1 421 49.5 7.72 1 1 81859.25781 115217.5469 62790.21094 132625.6719 1 1 1 1 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;metal ion binding Pf02668 55217 ENSG00000185973.10 TMLHE X Carnitine synthesis Lysine degradation 0 Medium P13667 Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2 0.05 1.064 1 1 1 1 645 72.9 5.07 1 1 185982.6094 94722.74219 49232.67578 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding;protein binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13905" 9601 ENSG00000155660.10 PDIA4 7 Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Vibrio cholerae infection 0 Medium P06733 Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2 0.05 1.066 2 1 1 1 434 47.1 7.39 1 1 215456.1094 149796.4063 213503.4219 308458.0625 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00113, Pf03952, Pf13378" 2023 ENSG00000074800.13 ENO1 1 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Glycolysis / Gluconeogenesis; RNA degradation; Biosynthesis of amino acids; Metabolic pathways 0 Medium O75947 "ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3" 0.043 1.093 6 1 1 1 161 18.5 5.3 1 1 24724.59375 105017.9297 177551.9063 1 1 1 cell organization and biogenesis;metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;transporter activity Pf05873 10476 ENSG00000167863.11 ATP5H 17 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 Medium Q99442 Translocation protein SEC62 OS=Homo sapiens OX=9606 GN=SEC62 PE=1 SV=1 0.014 1.476 2 1 1 1 399 45.8 7.12 1 1 33723.78906 141489.4531 223096.4531 1 1 1 cell organization and biogenesis;transport cytosol;endoplasmic reticulum;membrane receptor activity;transporter activity Pf03839 7095 ENSG00000008952.16 SEC62 3 XBP1(S) activates chaperone genes Protein export; Protein processing in endoplasmic reticulum 0 Medium O95218 Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2 0.014 1.503 3 1 1 1 330 37.4 10.01 1 1 28995.51563 434987.5313 68851.04688 68034.20313 1 1 1 1 metabolic process;regulation of biological process nucleus metal ion binding;protein binding;RNA binding Pf00641 9406 ENSG00000132485.13 ZRANB2 1 0 Medium P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2 0.016 1.349 2 1 1 1 404 45.5 5.07 1 1 138745.9688 1 coagulation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00027, Pf02197" 5576 ENSG00000114302.15 PRKAR2A 3 DARPP-32 events; ROBO receptors bind AKAP5; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; PKA activation in glucagon signalling; PKA activation Insulin signaling pathway 0 High P09669 Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2 0.002 2.31 11 1 1 1 75 8.8 10.39 1 1 252270.2031 368722.0313 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02937 1345 ENSG00000164919.10 COX6C 8 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 High Q7LGA3 Heparan sulfate 2-O-sulfotransferase 1 OS=Homo sapiens OX=9606 GN=HS2ST1 PE=1 SV=1 0.005 1.926 3 1 1 1 356 41.9 8.69 1 1 76318.49219 177861.9219 1 1 metabolic process Golgi;membrane catalytic activity Pf03567 9653 ENSG00000153936.16 HS2ST1 1 HS-GAG biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 Medium Q9NX46 ADP-ribose glycohydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1 0.015 1.551 6 1 1 1 363 38.9 5.07 1 1 10620583 10928301 10842450 12399258 1 1 1 1 response to stimulus cytoplasm;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding Pf03747 54936 ENSG00000116863.10 ADPRHL2 1 POLB-Dependent Long Patch Base Excision Repair 0 High Q9HCU5 Prolactin regulatory element-binding protein OS=Homo sapiens OX=9606 GN=PREB PE=1 SV=2 0 2.777 4 1 1 1 417 45.4 7.88 1 1 76351.6875 187675.3594 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;nucleus DNA binding;enzyme regulator activity;protein binding Pf00400 10113 ENSG00000138073.13 PREB 2 XBP1(S) activates chaperone genes; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport Protein processing in endoplasmic reticulum 0 Medium Q5JTH9 RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2 0.039 1.149 1 1 1 1 1297 143.6 8.75 1 1 152626.6563 91638.54688 1 1 membrane;nucleus RNA binding Pf08161 23223 ENSG00000052749.13 RRP12 10 0 High Q5TB80 Centrosomal protein of 162 kDa OS=Homo sapiens OX=9606 GN=CEP162 PE=1 SV=2 0 2.757 1 1 1 1 1403 161.8 5.47 1 1 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;nucleus protein binding 22832 ENSG00000135315.11 KIAA1009; CEP162 6 Anchoring of the basal body to the plasma membrane 0 Medium Q6IQ23 Pleckstrin homology domain-containing family A member 7 OS=Homo sapiens OX=9606 GN=PLEKHA7 PE=1 SV=2 0.014 1.501 1 1 1 1 1121 127.1 9.35 1 1 83460.69531 146651.5781 86532.21094 1 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;protein binding "Pf00169, Pf00397, Pf01576, Pf01920, Pf02463, Pf03961, Pf07798, Pf14992, Pf15409, Pf15413" 144100 ENSG00000166689.15 PLEKHA7 11 0 Medium Q08378 Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2 0.015 1.664 1 1 1 1 1498 167.3 5.44 1 1 210953.8125 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf01576, Pf02463, Pf04111, Pf05557, Pf07888, Pf10186, Pf12128, Pf12325" 2802 ENSG00000090615.14 GOLGA3 12 0 Medium Q9P109 "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 OS=Homo sapiens OX=9606 GN=GCNT4 PE=2 SV=1" 0.048 1.07 4 1 1 1 453 53 8.25 1 1 895724.4375 783248 1 1 metabolic process;response to stimulus Golgi;membrane catalytic activity Pf02485 51301 ENSG00000176928.5 GCNT4 5 O-linked glycosylation of mucins Mucin type O-glycan biosynthesis; Metabolic pathways 0 High P47929 Galectin-7 OS=Homo sapiens OX=9606 GN=LGALS7 PE=1 SV=2 0 3.604 8 1 1 1 136 15.1 7.62 1 1 475532.0625 1 cell death cytoplasm;extracellular;nucleus Pf00337 3963; 653499 ENSG00000282902.1; ENSG00000283082.1; ENSG00000205076.4; ENSG00000178934.4 LGALS7; LGALS7B 19; CHR_HG26_PATCH 0 High P55084 "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" 0 2.599 2 1 1 1 474 51.3 9.41 1 1 119217.6797 140897.2656 92149.60938 205940.6094 1 1 1 1 metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;protein binding;RNA binding "Pf00108, Pf00109, Pf02803" 3032 ENSG00000138029.13 HADHB 2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Fatty acid degradation; Fatty acid elongation; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 Medium Q9BS26 Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1 0.043 1.1 2 1 1 1 406 46.9 5.26 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00085, Pf01216, Pf07449, Pf13098, Pf13848" 23071 ENSG00000023318.7 ERP44 9 Neutrophil degranulation 0 Medium Q9BU76 Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1 0.015 1.649 5 1 1 1 263 29.4 10.02 1 1 199805.9531 283135.5 260300.875 191138.5 1 1 1 1 transport extracellular;organelle lumen protein binding;RNA binding Pf10159 79169 ENSG00000143793.12 C1orf35 1 Neutrophil degranulation 0 Medium P81605 Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2 0.025 1.235 10 1 1 1 110 11.3 6.54 1 1 128439.0938 62931.10938 154405.7188 90683.52344 1 1 1 1 defense response;metabolic process;response to stimulus extracellular catalytic activity;protein binding;RNA binding Pf15291 117159 ENSG00000161634.11 DCD 12 Antimicrobial peptides 0 Medium P20930 Filaggrin OS=Homo sapiens OX=9606 GN=FLG PE=1 SV=3 0.025 1.233 0 1 1 1 4061 434.9 9.25 1 1 799696.75 1 cell death;cell differentiation;development;metabolic process cytoskeleton;cytosol;nucleus metal ion binding;protein binding;structural molecule activity Pf01023 2312 ENSG00000143631.10 FLG 1 Formation of the cornified envelope 0 Medium O43837 "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" 0.021 1.303 2 1 1 1 385 42.2 8.46 1 1 136834.1875 135406.3594 1 1 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding Pf00180 3420 ENSG00000101365.20 IDH3B 20 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways 0 Medium Q01955 Collagen alpha-3(IV) chain OS=Homo sapiens OX=9606 GN=COL4A3 PE=1 SV=3 0.026 1.224 1 1 1 1 1670 161.7 9.16 1 1 6392868 7965004 8720626 4676232 1 1 1 1 cell death;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;organelle lumen enzyme regulator activity;protein binding;structural molecule activity "Pf01391, Pf01413" 1285 ENSG00000169031.18 COL4A3 2 ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Laminin interactions; Collagen chain trimerization; Crosslinking of collagen fibrils; Anchoring fibril formation; NCAM1 interactions; Signaling by PDGF; Non-integrin membrane-ECM interactions Amoebiasis; Protein digestion and absorption; Pathways in cancer; AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q96CS3 FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2 0 2.609 3 1 1 1 445 52.6 5.62 1 1 346029.4375 522588.3125 292548.5625 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;organelle lumen enzyme regulator activity;protein binding "Pf00789, Pf14555" 23197 ENSG00000113194.12 FAF2 5 Neutrophil degranulation 0 Medium Q92890 Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3 0.025 1.231 3 1 1 1 307 34.5 6.7 1 1 134364.875 41392.07813 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;nucleus catalytic activity;protein binding Pf03152 7353 ENSG00000070010.18 UFD1L; UFD1 22 Ub-specific processing proteases; Translesion Synthesis by POLH Protein processing in endoplasmic reticulum 0 Medium O76021 Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3 0.03 1.204 2 1 1 1 490 54.9 10.13 1 1 120671.5078 135335.2188 168529.0938 1 1 1 cell differentiation;metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding "Pf06030, Pf11797" 26156 ENSG00000171490.12 RSL1D1 16 0 High Q9BVT8 Transmembrane and ubiquitin-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TMUB1 PE=1 SV=1 0 3.574 4 1 1 1 246 26.2 5.72 1 1 86117.67188 485606.9063 686159.1875 1 1 1 metabolic process cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus protein binding "Pf00240, Pf10302, Pf13881" 83590 ENSG00000164897.12 TMUB1 7 0 Medium Q8TD19 Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2 0.021 1.297 1 1 1 1 979 107.1 5.74 1 1 cell division;cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00415, Pf07714, Pf13540, Pf14531" 91754 ENSG00000119638.12 NEK9 14 "Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly" 0 Medium Q9BYR9 Keratin-associated protein 2-4 OS=Homo sapiens OX=9606 GN=KRTAP2-4 PE=1 SV=1 0.014 1.488 18 1 1 1 128 13.5 7.87 1 1 cytosol protein binding 85294; 730755 ENSG00000212724.3; ENSG00000213417.3; ENSG00000262862.2; ENSG00000263091.2 KRTAP2-4; KRTAP2-3 17; CHR_HSCHR17_4_CTG4 Keratinization 0 Medium P33993 DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4 0.044 1.123 1 1 1 1 719 81.3 6.46 1 1 163316.2344 125390.8672 187501.2188 222925.875 1 1 1 1 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 4176 ENSG00000166508.17 MCM7 7 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 Medium Q9BZF1 Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3 0.014 1.405 1 1 1 1 889 101.1 6.96 1 1 256988.4375 202663.1875 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;endoplasmic reticulum;membrane;nucleus transporter activity "Pf00169, Pf01237" 114882 ENSG00000091039.16 OSBPL8 12 Acyl chain remodelling of PS 0 Low O14653 Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2 0.053 1.044 3 1 1 1 212 24.8 8.06 1 1 66722.23438 126980.7422 176396.2969 1 1 1 cell organization and biogenesis;transport cytosol;endoplasmic reticulum;Golgi;membrane protein binding Pf12352 9570 ENSG00000108433.16 GOSR2 17 Intra-Golgi traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; XBP1(S) activates chaperone genes SNARE interactions in vesicular transport 0 Medium Q6PKG0 La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2 0.049 1.054 1 1 1 1 1096 123.4 8.82 1 1 134257.7813 62733.12109 1 1 cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane protein binding;RNA binding;translation regulator activity Pf05383 23367 LARP1 5 0 High P40939 "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" 0 2.614 2 1 1 1 763 82.9 9.04 1 1 244902.8281 257253.375 299949.7188 437030.9375 1 1 1 1 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00378, Pf00725, Pf02737" 3030 ENSG00000084754.10 HADHA 2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Butanoate metabolism; Fatty acid degradation; Propanoate metabolism; Carbon metabolism; Lysine degradation; beta-Alanine metabolism; Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 Medium P02545 Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1 0.014 1.52 1 1 1 1 664 74.1 7.02 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf00932" 4000 ENSG00000160789.19 LMNA 1 Signaling by BRAF and RAF fusions; Breakdown of the nuclear lamina; XBP1(S) activates chaperone genes; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Depolymerisation of the Nuclear Lamina; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Apoptosis; Hypertrophic cardiomyopathy (HCM) 0 Medium O43823 A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1 0.014 1.418 1 1 1 1 692 76.1 5.15 1 1 68033.47656 70082.29688 158539.4688 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;Golgi;membrane;mitochondrion;nucleus DNA binding;metal ion binding;protein binding;RNA binding Pf04988 10270 ENSG00000105127.8 AKAP8 19 0 Medium O60841 Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4 0.014 1.391 1 1 1 1 1220 138.7 5.49 1 1 35684.69141 245598.2969 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00009, Pf01926, Pf03144, Pf11987, Pf14578" 9669 ENSG00000158417.10 EIF5B 2 GTP hydrolysis and joining of the 60S ribosomal subunit RNA transport 0 Medium Q9BYN8 "28S ribosomal protein S26, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" 0.016 1.358 4 1 1 1 205 24.2 10.39 1 1 66771.42188 102287.8516 100915.5234 1 1 1 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome RNA binding Pf14943 64949 ENSG00000125901.5 MRPS26 20 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 Medium Q96S52 GPI transamidase component PIG-S OS=Homo sapiens OX=9606 GN=PIGS PE=1 SV=3 0.015 1.605 1 1 1 1 555 61.6 6.49 1 1 186103.9844 1 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf10510 94005 ENSG00000087111.20 PIGS 17 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 Medium Q9Y265 RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1 0.025 1.232 2 1 1 1 456 50.2 6.42 1 1 255996.0781 142316.8281 183076.3281 158458.6875 1 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07726, Pf13191, Pf13238, Pf13245, Pf13481" 8607 ENSG00000175792.11 RUVBL1 3 Ub-specific processing proteases; UCH proteinases; DNA Damage Recognition in GG-NER; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; Deposition of new CENPA-containing nucleosomes at the centromere Wnt signaling pathway 0 Medium Q10713 Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2 0.015 1.561 2 1 1 1 525 58.2 6.92 1 1 metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf00675, Pf05193" 23203 ENSG00000165688.11 PMPCA 9 Processing of SMDT1; Mitochondrial protein import; Metabolism of proteins 0 Medium Q6Y7W6 GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1 0.016 1.362 1 1 1 1 1299 150 5.54 1 1 328775.6563 296245.9688 400908 331064.5 1 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane protein binding;RNA binding Pf02213 26058 ENSG00000204120.14 GIGYF2 2 0