Protein FDR Confidence: Combined Accession Description Exp. q-value: Combined Sum PEP Score Coverage [%] # Peptides # PSMs # Unique Peptides # AAs MW [kDa] calc. pI # Peptides (by Search Engine): A2 Sequest HT (5W kidney IgG) # Peptides (by Search Engine): B2 Sequest HT (5W kidney SKO) # Peptides (by Search Engine): C2 Sequest HT (5W kidney WT) # PSMs (by Search Engine): A2 Sequest HT (5W kidney IgG) # PSMs (by Search Engine): B2 Sequest HT (5W kidney SKO) # PSMs (by Search Engine): C2 Sequest HT (5W kidney WT) "Abundance: F1: Sample, 5W kidney IgG" "Abundance: F2: Sample, 5W Kidney SKO" "Abundance: F3: Sample, 5W kidney WT" "Abundances Count: F1: Sample, 5W kidney IgG" "Abundances Count: F2: Sample, 5W Kidney SKO" "Abundances Count: F3: Sample, 5W kidney WT" Modifications Biological Process Cellular Component Molecular Function Pfam IDs Entrez Gene ID Ensembl Gene ID Gene Symbol Chromosome Reactome Pathways KEGG Pathways # Razor Peptides High Q8VDD5 Myosin-9 OS=Mus musculus OX=10090 GN=Myh9 PE=1 SV=4 0 3218.888 81 227 5863 167 1960 226.2 5.66 179 200 215 970 2307 2586 13744389561 56921831101 71932322592 332 360 363 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00063, Pf01442, Pf01496, Pf01576, Pf01765, Pf02463, Pf02736, Pf03962, Pf04111, Pf04156, Pf05667, Pf05911, Pf06160, Pf06637, Pf07111, Pf07888, Pf08317, Pf09726, Pf09731, Pf10498, Pf11559, Pf11917, Pf12128, Pf13094, Pf13166" 17886 ENSMUSG00000022443.16 Myh9 15 RHO GTPases activate PAKs Regulation of actin cytoskeleton; Tight junction 97 High P63260 "Actin, cytoplasmic 2 OS=Mus musculus OX=10090 GN=Actg1 PE=1 SV=1" 0 1107.61 99 49 3700 1 375 41.8 5.48 35 43 46 731 1259 1710 543295977.1 734165748.9 1126897759 5 5 5 Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane;nucleus nucleotide binding;protein binding;structural molecule activity Pf00022 11465 ENSMUSG00000062825.15 Actg1 11 Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate IQGAPs; Formation of annular gap junctions; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling Oxytocin signaling pathway; Leukocyte transendothelial migration; Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Hippo signaling pathway; Platelet activation; Dilated cardiomyopathy; Adherens junction; Phagosome; Proteoglycans in cancer; Salmonella infection; Thyroid hormone signaling pathway; Rap1 signaling pathway; Influenza A; Viral myocarditis; Tight junction; Bacterial invasion of epithelial cells; Apoptosis 0 High P60710 "Actin, cytoplasmic 1 OS=Mus musculus OX=10090 GN=Actb PE=1 SV=1" 0 1103.14 99 49 3619 1 375 41.7 5.48 35 43 46 692 1233 1694 19655836581 37107383776 47635387941 82 94 97 Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;nucleotide binding;protein binding Pf00022 11461 ENSMUSG00000029580.14 Actb 5 Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; UCH proteinases; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases activate IQGAPs; Formation of annular gap junctions; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling Oxytocin signaling pathway; Leukocyte transendothelial migration; Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Hippo signaling pathway; Platelet activation; Dilated cardiomyopathy; Adherens junction; Phagosome; Proteoglycans in cancer; Salmonella infection; Thyroid hormone signaling pathway; Rap1 signaling pathway; Influenza A; Viral myocarditis; Tight junction; Gastric acid secretion; Bacterial invasion of epithelial cells; Apoptosis 100 High A0A338P6K2 Myosin-11 OS=Mus musculus OX=10090 GN=Myh11 PE=1 SV=1 0 2466.198 75 208 3573 3 1979 227.7 5.48 161 175 198 746 1105 1722 8343067049 19496625739 43370985232 242 247 266 270 High E9QPE7 Myosin-11 OS=Mus musculus OX=10090 GN=Myh11 PE=1 SV=2 0 2445.158 75 207 3559 2 1972 227 5.48 160 175 197 743 1101 1715 15824891 66205020 127632736 2 2 2 0 High P16546 "Spectrin alpha chain, non-erythrocytic 1 OS=Mus musculus OX=10090 GN=Sptan1 PE=1 SV=4" 0 2446.97 82 241 1970 6 2472 284.4 5.33 181 214 234 448 726 796 3833490791 10315127000 13897239733 279 287 297 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane metal ion binding;protein binding "Pf00018, Pf00036, Pf00435, Pf07653, Pf08239, Pf08726, Pf12128, Pf13405, Pf13499, Pf14604" 20740 ENSMUSG00000057738.13 Spna2; Sptan1 2 NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; Neutrophil degranulation; Interleukin-20 family signaling; RAF/MAP kinase cascade; Caspase-mediated cleavage of cytoskeletal proteins 299 High A3KGU5 "Spectrin alpha chain, non-erythrocytic 1 OS=Mus musculus OX=10090 GN=Sptan1 PE=1 SV=1" 0 2430.417 81 238 1955 3 2457 282.7 5.33 179 213 231 443 722 790 13256088.44 28797804.88 37483859.5 3 3 3 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane metal ion binding;protein binding "Pf00018, Pf00036, Pf00435, Pf07653, Pf08239, Pf08726, Pf12128, Pf13405, Pf13499, Pf14604" 20740 ENSMUSG00000057738.13 Spna2; Sptan1 2 0 High Q3UH59 Myosin-10 OS=Mus musculus OX=10090 GN=Myh10 PE=1 SV=1 0 1735.238 70 178 1909 138 2013 233.3 5.57 133 157 168 362 713 834 909207316 4466194666 4642506232 148 166 165 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;extracellular;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf00063, Pf00769, Pf01442, Pf01496, Pf01576, Pf02736, Pf02841, Pf04012, Pf04111, Pf05622, Pf05667, Pf05911, Pf06637, Pf07888, Pf09726, Pf09731, Pf12128, Pf13094, Pf13514" 77579 ENSMUSG00000020900.15 Myh10 11 Regulation of actin cytoskeleton; Tight junction 2 High Q62261 "Spectrin beta chain, non-erythrocytic 1 OS=Mus musculus OX=10090 GN=Sptbn1 PE=1 SV=2" 0 2017.344 77 204 1729 190 2363 274.1 5.58 145 174 194 362 628 739 2374237755 7179864715 11013873561 211 227 238 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;membrane;nucleus protein binding;RNA binding;structural molecule activity "Pf00169, Pf00307, Pf00435, Pf11971, Pf12128, Pf15410" 20742 ENSMUSG00000020315.18 Spnb2; Sptbn1 11 RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; Interleukin-20 family signaling Tight junction 19 High Q68FD5 Clathrin heavy chain 1 OS=Mus musculus OX=10090 GN=Cltc PE=1 SV=3 0 1668.683 81 125 1628 125 1675 191.4 5.69 99 113 117 410 564 654 4190740343 7464092445 11573550105 152 157 162 Met-loss+Acetyl [N-Term] cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;mitochondrion;vacuole protein binding;RNA binding;structural molecule activity "Pf00637, Pf01394, Pf04053, Pf09268, Pf13838" 67300 ENSMUSG00000047126.17 Cltc 11 "WNT5A-dependent internalization of FZD4; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Lysosome; Huntington's disease; Synaptic vesicle cycle; Bacterial invasion of epithelial cells 0 High P62737 "Actin, aortic smooth muscle OS=Mus musculus OX=10090 GN=Acta2 PE=1 SV=1" 0 585.198 90 43 1502 1 377 42 5.39 27 34 39 298 536 668 1378639708 2655391524 5165572192 28 29 34 regulation of biological process;response to stimulus cytoplasm;cytoskeleton nucleotide binding;protein binding Pf00022 11475 ENSMUSG00000035783.8 Acta2 19 Smooth Muscle Contraction Vascular smooth muscle contraction 33 High P68134 "Actin, alpha skeletal muscle OS=Mus musculus OX=10090 GN=Acta1 PE=1 SV=1" 0 472.141 85 38 1497 2 377 42 5.39 25 30 34 319 554 624 360604.3125 7154088 22588145.25 1 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton nucleotide binding;protein binding Pf00022 11459 ENSMUSG00000031972.5 Acta1 8 Striated Muscle Contraction 0 High P63268 "Actin, gamma-enteric smooth muscle OS=Mus musculus OX=10090 GN=Actg2 PE=1 SV=1" 0 501.878 86 39 1359 1 376 41.9 5.48 26 31 35 296 500 563 6736224 451466.4063 1 1 Met-loss [N-Term] regulation of biological process cytoplasm;cytoskeleton nucleotide binding Pf00022 11468 ENSMUSG00000059430.14 Actg2 6 Smooth Muscle Contraction Vascular smooth muscle contraction 0 High P57780 Alpha-actinin-4 OS=Mus musculus OX=10090 GN=Actn4 PE=1 SV=1 0 1047.178 84 77 1228 45 912 104.9 5.41 64 72 75 252 427 549 2225935411 5563284175 8371148655 114 123 125 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00307, Pf00435, Pf08726, Pf11971, Pf13499" 60595 ENSMUSG00000054808.15 Actn4 7 Platelet degranulation Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Adherens junction; Tight junction; Systemic lupus erythematosus; Amoebiasis; Viral carcinogenesis 53 High Q62468 Villin-1 OS=Mus musculus OX=10090 GN=Vil1 PE=1 SV=3 0 761.466 83 63 1123 63 827 92.7 6.04 51 60 59 202 436 485 2232210008 9170793390 11794613670 92 100 98 Met-loss [N-Term] cell death;cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00626, Pf02209" 22349 ENSMUSG00000026175.12 Vil1 1 0 High F8WGM8 "Actin, cytoplasmic 2 (Fragment) OS=Mus musculus OX=10090 GN=Actg1 PE=1 SV=1" 0 356.838 92 14 1095 1 105 11.9 7.21 10 10 12 202 384 509 1463342.5 2267240.25 1 1 Pf00022 ENSMUSG00000062825.15 11 0 High Q8BFZ3 Beta-actin-like protein 2 OS=Mus musculus OX=10090 GN=Actbl2 PE=1 SV=1 0 240.015 57 20 982 6 376 42 5.49 10 17 18 172 343 467 48058447 187570380.3 290149835.5 6 7 7 cytoplasm;cytoskeleton nucleotide binding Pf00022 238880 ENSMUSG00000055194.3 Actbl2 13 0 High V9GX76 Unconventional myosin-VI OS=Mus musculus OX=10090 GN=Myo6 PE=1 SV=1 0 947.372 73 103 980 2 1294 149.1 8.46 86 86 96 279 326 375 2069806753 3919052646 5593044073 124 124 127 Acetyl [N-Term] cell communication;cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;Golgi;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding Pf00063 17920 ENSMUSG00000033577.18 Myo6 9 Trafficking of AMPA receptors; Gap junction degradation 130 High E9PVU0 Unconventional myosin-VI OS=Mus musculus OX=10090 GN=Myo6 PE=1 SV=1 0 940.334 74 102 977 1 1266 146.2 8.47 85 85 95 278 325 374 15129991 32238769 40510046 1 1 1 Acetyl [N-Term] catalytic activity;motor activity;nucleotide binding Pf00063 ENSMUSG00000033577.18 9 Trafficking of AMPA receptors; Gap junction degradation 0 High Q7TPR4 Alpha-actinin-1 OS=Mus musculus OX=10090 GN=Actn1 PE=1 SV=1 0 824.243 83 74 843 3 892 103 5.38 49 64 72 152 312 379 3397665.859 18569445.81 23711586.63 2 3 3 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00036, Pf00307, Pf00435, Pf08726, Pf11971, Pf13405, Pf13499" 109711 ENSMUSG00000015143.15 Actn1 12 Platelet degranulation ; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Adherens junction; Tight junction; Systemic lupus erythematosus; Amoebiasis; Viral carcinogenesis 0 High A1BN54 Alpha actinin 1a OS=Mus musculus OX=10090 GN=Actn1 PE=1 SV=1 0 808.997 82 74 838 3 887 102.7 5.48 50 63 72 154 309 375 314943943.1 1368957197 2087187446 56 60 65 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00307, Pf00435, Pf08726, Pf11971, Pf13499, Pf13833" 109711 ENSMUSG00000015143.15 Actn1 12 64 High Q6URW6 Myosin-14 OS=Mus musculus OX=10090 GN=Myh14 PE=1 SV=1 0 893.499 63 129 805 112 2000 228.4 5.55 87 107 118 183 289 333 787736022.8 2040681656 2564852207 103 110 114 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf01576, Pf09726" 71960 ENSMUSG00000030739.18 Myh14 7 RHO GTPases activate PAKs Regulation of actin cytoskeleton; Tight junction 0 High P08032 "Spectrin alpha chain, erythrocytic 1 OS=Mus musculus OX=10090 GN=Spta1 PE=1 SV=3" 0 1258.393 77 170 709 169 2415 279.7 5.03 91 143 147 123 278 308 727799098.2 1574996279 2163702872 140 156 164 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane metal ion binding;protein binding "Pf00018, Pf00435, Pf07653, Pf08726, Pf14604" 20739 ENSMUSG00000026532.7 Spna1; Spta1 1 RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; Interleukin-20 family signaling Apoptosis 0 High A0A2R8VKI5 Myosin-9 (Fragment) OS=Mus musculus OX=10090 GN=Myh9 PE=1 SV=1 0 365.807 74 24 709 1 211 25.4 5.39 19 22 23 125 275 309 25959559.06 192353827.7 413349913.5 1 1 1 0 High A0A1W2P6G5 Myosin light polypeptide 6 OS=Mus musculus OX=10090 GN=Myl6 PE=1 SV=1 0 240.84 86 12 663 1 139 15.4 4.54 12 11 10 112 255 296 85737730.41 184602437.9 227191553.5 5 5 5 metal ion binding Pf13499 ENSMUSG00000090841.2 10 0 High Q3UGX2 Spectrin beta chain OS=Mus musculus OX=10090 GN=Sptb PE=1 SV=1 0 936.289 65 137 654 130 2329 267.9 5.49 84 119 123 135 245 274 344890413.1 1215917750 1563386191 115 128 129 cell organization and biogenesis;metabolic process;regulation of biological process cell surface;cytoplasm;cytoskeleton;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf00169, Pf00307, Pf00435, Pf11971, Pf13514, Pf15410" 20741 ENSMUSG00000021061.15 Spnb1; Sptb 12 RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; Interleukin-20 family signaling 0 High Q9WTI7 Unconventional myosin-Ic OS=Mus musculus OX=10090 GN=Myo1c PE=1 SV=2 0 582.195 70 71 651 71 1063 121.9 9.35 64 61 66 167 228 256 972593396.6 1983561940 3311195602 80 78 80 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 17913 ENSMUSG00000017774.19 Myo1c 11 Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression 1 High Q64331 Unconventional myosin-VI OS=Mus musculus OX=10090 GN=Myo6 PE=1 SV=1 0 604.252 56 80 630 1 1265 146.3 8.85 64 64 73 182 213 235 1153327.125 1 Acetyl [N-Term] cell communication;cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;Golgi;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding Pf00063 17920 Myo6 9 0 High Q68FG2 Spectrin beta chain OS=Mus musculus OX=10090 GN=Sptbn2 PE=1 SV=1 0 937.8 61 125 577 113 2388 270.8 5.86 83 103 107 139 212 226 380724084 876184257.1 1060908500 103 113 109 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane protein binding;structural molecule activity "Pf00169, Pf00307, Pf00435, Pf11971, Pf15410" 20743 ENSMUSG00000067889.4 Spnb3; Sptbn2 19 RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; MHC class II antigen presentation; Interleukin-20 family signaling 0 High Q6ZWQ9 "Myosin, light chain 12A, regulatory, non-sarcomeric OS=Mus musculus OX=10090 GN=Myl12a PE=1 SV=1" 0 223.202 85 14 524 4 172 19.9 4.81 14 13 14 71 203 250 122654400.1 431659500.9 479847441 10 11 10 cell organization and biogenesis;regulation of biological process metal ion binding;protein binding "Pf00036, Pf13202, Pf13405" 67268 ENSMUSG00000024048.14 Myl12a 17 Ephrin signaling; Smooth Muscle Contraction Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Focal adhesion; Platelet activation; Tight junction 0 High Q60605 Myosin light polypeptide 6 OS=Mus musculus OX=10090 GN=Myl6 PE=1 SV=3 0 225.994 93 14 511 3 151 16.9 4.65 14 13 12 90 190 231 3324877872 9733691636 12655911911 26 27 27 Met-loss+Acetyl [N-Term] cellular component movement membrane catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity "Pf00036, Pf13405, Pf13499" 17904 ENSMUSG00000090841.2 Myl6 10 RHO GTPases activate PAKs; Smooth Muscle Contraction Oxytocin signaling pathway; Vascular smooth muscle contraction 22 High Q3THE2 Myosin regulatory light chain 12B OS=Mus musculus OX=10090 GN=Myl12b PE=1 SV=2 0 249.339 85 16 448 3 172 19.8 4.84 13 14 16 73 165 210 1728724159 5844780386 8168871307 27 29 30 regulation of biological process metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13833" 67938 ENSMUSG00000034868.8 Myl12b 17 RHO GTPases activate PAKs; Smooth Muscle Contraction Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Focal adhesion; Platelet activation; Tight junction 25 High Q9CQ19 Myosin regulatory light polypeptide 9 OS=Mus musculus OX=10090 GN=Myl9 PE=1 SV=3 0 265.321 85 16 425 7 172 19.8 4.92 13 14 16 80 137 208 487343418.3 1250479121 1944691106 13 13 13 metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13833" 98932 ENSMUSG00000067818.6 Myl9 2 RHO GTPases activate PAKs; Smooth Muscle Contraction Oxytocin signaling pathway; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Focal adhesion; cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Tight junction 0 High Q5SYD0 Unconventional myosin-Id OS=Mus musculus OX=10090 GN=Myo1d PE=1 SV=1 0 488.557 70 72 408 69 1006 116 9.41 56 64 64 103 138 167 426594073.5 770195554.1 1111407188 80 84 83 Met-loss+Acetyl [N-Term] regulation of biological process;transport cytosol;endoplasmic reticulum;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 338367 ENSMUSG00000035441.14 Myo1d 11 3 High F8WID5 Tropomyosin alpha-1 chain OS=Mus musculus OX=10090 GN=Tpm1 PE=1 SV=1 0 314.783 74 43 398 2 326 37.4 4.72 34 39 41 86 137 175 594309696.6 1970829780 3582443075 29 29 30 "Pf00261, Pf12718" ENSMUSG00000032366.15 9 29 High K3W4L0 Unconventional myosin-XVIIIa OS=Mus musculus OX=10090 GN=Myo18a PE=1 SV=1 0 635.71 59 104 388 104 2036 230.8 6.19 50 80 89 68 157 163 192665409.2 636661215.7 803410591.2 90 96 100 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00063, Pf00595, Pf00769, Pf01496, Pf01576, Pf02463, Pf02841, Pf03962, Pf04111, Pf04156, Pf04502, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06160, Pf07111, Pf07888, Pf08286, Pf09726, Pf09728, Pf09730, Pf09755, Pf09787, Pf10174, Pf12128, Pf12329, Pf13166, Pf13514, Pf13851, Pf15070, Pf15397" ENSMUSG00000000631.20 11 0 High G5E8G6 Unconventional myosin-Vb OS=Mus musculus OX=10090 GN=Myo5b PE=1 SV=1 0 579.063 64 102 383 92 1818 210.4 7.09 66 84 84 91 148 144 251349579.3 558097212.8 1140370490 86 95 96 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;endosome catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf01576, Pf01843, Pf02463, Pf03938, Pf04111, Pf05557, Pf05622, Pf05667, Pf07888, Pf07926, Pf12128, Pf13514" 17919 ENSMUSG00000025885.18 Myo5b 18 Vasopressin regulates renal water homeostasis via Aquaporins 10 High Q80X90 Filamin-B OS=Mus musculus OX=10090 GN=Flnb PE=1 SV=3 0 637.599 59 111 381 103 2602 277.7 5.71 45 83 97 58 143 180 141054521.2 508857516.6 739475711.1 89 106 105 Met-loss [N-Term] cell differentiation;cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding "Pf00307, Pf00630" 286940 ENSMUSG00000025278.8 Flnb 14 ISG15 antiviral mechanism MAPK signaling pathway; Focal adhesion; Proteoglycans in cancer; Salmonella infection 8 High Q99MZ6 Unconventional myosin-VIIb OS=Mus musculus OX=10090 GN=Myo7b PE=1 SV=3 0 526.316 57 101 357 99 2113 240.7 8.92 45 87 84 62 156 139 146451211 609639234.9 732702682 74 95 97 cell differentiation cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00018, Pf00063, Pf00373, Pf00612, Pf00784, Pf07653, Pf14604" 17922 ENSMUSG00000024388.10 Myo7b 18 2 High E9Q448 Tropomyosin alpha-1 chain OS=Mus musculus OX=10090 GN=Tpm1 PE=1 SV=1 0 246.072 77 38 351 1 284 32.8 4.75 32 37 35 80 118 153 12659565 33750424 96426272 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf00261, Pf12718" 22003 ENSMUSG00000032366.15 Tpm1 9 0 High Q9JKF1 Ras GTPase-activating-like protein IQGAP1 OS=Mus musculus OX=10090 GN=Iqgap1 PE=1 SV=2 0 621.282 62 89 339 84 1657 188.6 6.48 33 65 82 42 130 167 200268634.1 697234231.6 877618983.3 69 85 90 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell growth;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus enzyme regulator activity;protein binding "Pf00307, Pf00616, Pf03836, Pf11016" 29875 ENSMUSG00000030536.10 Iqgap1 7 Nephrin family interactions; RHO GTPases activate IQGAPs; Neutrophil degranulation Regulation of actin cytoskeleton; Adherens junction; Proteoglycans in cancer 6 High Q8BP43 Tropomyosin alpha-1 chain OS=Mus musculus OX=10090 GN=Tpm1 PE=1 SV=1 0 269.503 74 42 335 4 284 32.8 4.77 31 38 37 78 121 136 74048565.18 278568530.3 329487976.1 8 8 7 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf00261, Pf12718" 22003 ENSMUSG00000032366.15 Tpm1 9 5 High G5E8R2 Tropomyosin alpha-1 chain OS=Mus musculus OX=10090 GN=Tpm1 PE=1 SV=1 0 235.533 81 36 334 7 248 28.7 4.78 29 33 32 80 114 140 95072444.5 258115993.5 361879584.3 6 7 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf00261, Pf12718" 22003 ENSMUSG00000032366.15 Tpm1 9 0 High E9Q7Q3 Tropomyosin alpha-3 chain OS=Mus musculus OX=10090 GN=Tpm3 PE=1 SV=1 0 223.171 67 33 288 6 248 28.7 4.72 23 31 32 67 104 117 38888603.77 176006142.2 300531683.6 6 6 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf00261, Pf12718" 59069 ENSMUSG00000027940.18 Tpm3 3 0 High D3Z2H9 "Tropomyosin 3, related sequence 7 OS=Mus musculus OX=10090 GN=Tpm3-rs7 PE=3 SV=1" 0 207.734 81 37 288 10 248 29 4.81 26 32 35 67 99 122 412618128.1 1121301697 2195791646 23 22 24 Met-loss+Acetyl [N-Term] cell organization and biogenesis protein binding;structural molecule activity "Pf00261, Pf12718" ENSMUSG00000058126.6 14 Striated Muscle Contraction; Smooth Muscle Contraction 14 High Q9DBG3 AP-2 complex subunit beta OS=Mus musculus OX=10090 GN=Ap2b1 PE=1 SV=1 0 387.17 66 57 284 32 937 104.5 5.38 45 47 48 84 98 102 273877238.7 596520894.8 752603879.6 59 59 59 cell organization and biogenesis;transport membrane protein binding;transporter activity "Pf01602, Pf02883, Pf09066, Pf12717, Pf13646" 71770 ENSMUSG00000035152.14 Ap2b1 11 "WNT5A-dependent internalization of FZD4; Trafficking of GluR2-containing AMPA receptors; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Huntington's disease; Synaptic vesicle cycle 26 High A2AIM4 Tropomyosin beta chain OS=Mus musculus OX=10090 GN=Tpm2 PE=1 SV=1 0 243.09 71 43 271 26 284 33 4.69 29 32 41 58 87 126 606274944.3 2016461011 4730306585 42 43 45 cell organization and biogenesis cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf00261, Pf12718" 22004 ENSMUSG00000028464.16 Tpm2 4 19 High P17427 AP-2 complex subunit alpha-2 OS=Mus musculus OX=10090 GN=Ap2a2 PE=1 SV=2 0 294.464 58 45 251 33 938 104 6.93 33 40 41 66 88 97 229798371.9 515236430.3 621172779 48 46 45 regulation of biological process;transport Golgi;membrane protein binding;transporter activity "Pf01602, Pf02296, Pf02883, Pf13646" 11772 ENSMUSG00000002957.11 Ap2a2 7 "WNT5A-dependent internalization of FZD4; Trafficking of GluR2-containing AMPA receptors; Neutrophil degranulation; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Huntington's disease; Synaptic vesicle cycle 13 High Q9Z2G6 Protein sel-1 homolog 1 OS=Mus musculus OX=10090 GN=Sel1l PE=1 SV=2 0 457.744 68 35 250 35 790 88.3 5.57 33 32 127 123 19093476.09 1054051933 1058412773 7 47 46 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding "Pf00040, Pf08238" 20338 ENSMUSG00000020964.14 Sel1l 12 Hedgehog ligand biogenesis; ABC-family proteins mediated transport; ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High Q9JI91 Alpha-actinin-2 OS=Mus musculus OX=10090 GN=Actn2 PE=1 SV=2 0 179.769 19 20 242 2 894 103.8 5.45 13 18 19 37 86 119 10566023.63 70678103.75 99993370.75 2 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane metal ion binding;protein binding "Pf00307, Pf00435, Pf08726, Pf11971, Pf13499, Pf13833" 11472 ENSMUSG00000052374.14 Actn2 13 "RAF/MAP kinase cascade; CREB phosphorylation through the activation of CaMKII; Ras activation uopn Ca2+ infux through NMDA receptor; Platelet degranulation ; Striated Muscle Contraction; Unblocking of NMDA receptor, glutamate binding and activation; Interleukin-20 family signaling" Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Adherens junction; Tight junction; Systemic lupus erythematosus; Amoebiasis; Viral carcinogenesis 0 High D3Z0L8 Alpha-actinin-4 (Fragment) OS=Mus musculus OX=10090 GN=Actn4 PE=1 SV=1 0 218.948 75 15 234 1 206 23.3 7.97 11 14 15 40 83 111 363129.0313 15698632.53 27827830.19 1 3 3 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding "Pf00307, Pf11971" ENSMUSG00000054808.15 7 0 High P63017 Heat shock cognate 71 kDa protein OS=Mus musculus OX=10090 GN=Hspa8 PE=1 SV=1 0 224.838 62 36 217 30 646 70.8 5.52 25 30 35 53 76 88 267550252.8 520312028.4 708884747.5 38 43 39 cell organization and biogenesis;metabolic process;regulation of biological process;transport cell surface;cytoplasm;cytosol;endosome;membrane;nucleus;spliceosomal complex;vacuole catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00012, Pf02463, Pf06723" 15481 ENSMUSG00000015656.17 Hspa8 9 "Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; mRNA Splicing - Major Pathway; Attenuation phase; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; GABA synthesis, release, reuptake and degradation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Protein methylation; Clathrin-mediated endocytosis" Endocytosis; MAPK signaling pathway; Toxoplasmosis; Epstein-Barr virus infection; Spliceosome; Legionellosis; Influenza A; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Measles; Longevity regulating pathway - multiple species 6 High E9QNH6 Unconventional myosin-Ib OS=Mus musculus OX=10090 GN=Myo1b PE=1 SV=1 0 293.359 51 50 196 1 1078 125 9.14 29 42 40 49 70 77 534020.875 1479764.25 3591588 1 1 1 cell organization and biogenesis;cellular component movement;transport cytoplasm;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 17912 ENSMUSG00000018417.14 Myo1b 1 0 High P46735 Unconventional myosin-Ib OS=Mus musculus OX=10090 GN=Myo1b PE=1 SV=3 0 294.664 50 50 196 1 1107 128.5 9.26 29 42 40 49 70 77 119885087.9 255524091.3 469685941.5 43 44 48 cell organization and biogenesis;cellular component movement;transport cytoplasm;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 17912 ENSMUSG00000018417.14 Myo1b 1 47 High Q9JLB4 Cubilin OS=Mus musculus OX=10090 GN=Cubn PE=1 SV=3 0 314.583 25 68 194 68 3623 398.8 5.76 50 43 47 65 56 73 148820227.3 153031218.8 252247833.3 63 62 60 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane;organelle lumen;vacuole metal ion binding;protein binding;receptor activity;transporter activity "Pf00008, Pf00431, Pf07645, Pf12947, Pf14670" 65969 ENSMUSG00000026726.10 Cubn 2 "Cobalamin (Cbl, vitamin B12) transport and metabolism; HDL clearance; Vitamin D (calciferol) metabolism" Vitamin digestion and absorption 0 High E9PWQ3 "Collagen, type VI, alpha 3 OS=Mus musculus OX=10090 GN=Col6a3 PE=1 SV=2" 0 399.09 31 72 194 72 3284 353.7 6.93 32 47 61 36 61 97 69856807.51 216765831.2 438207148.3 57 65 66 regulation of biological process extracellular;membrane enzyme regulator activity;protein binding "Pf00014, Pf00041, Pf00092, Pf01391, Pf13519, Pf13768" ENSMUSG00000048126.16 1 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures 0 High P16460 Argininosuccinate synthase OS=Mus musculus OX=10090 GN=Ass1 PE=1 SV=1 0 228 71 29 191 29 412 46.6 8.22 22 27 29 39 72 80 130284764.2 483570621.4 728001042.6 28 29 30 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;vacuole catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00764, Pf03054, Pf06508" 11898 ENSMUSG00000076441.9 Ass1 2 Urea cycle "Metabolic pathways; Biosynthesis of amino acids; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis" 0 High P0DP27 Calmodulin-2 OS=Mus musculus OX=10090 GN=Calm2 PE=1 SV=1 0 183.387 82 13 187 6 149 16.8 4.22 13 12 12 46 63 78 447910205.1 923186472.8 1272719141 22 21 22 Met-loss+Acetyl [N-Term] regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding "Pf00036, Pf08726, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658" 12315; 12313; 12314 ENSMUSG00000001175.13; ENSMUSG00000036438.12; ENSMUSG00000019370.10 Calm3; Calm1; Calm2 7; 12; 17 Oxytocin signaling pathway; Dopaminergic synapse; Ras signaling pathway; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Tuberculosis; Melanogenesis; Oocyte meiosis; Pertussis; Neurotrophin signaling pathway; cGMP-PKG signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Olfactory transduction; Phototransduction; Gastric acid secretion; Renin secretion; Circadian entrainment; Glioma; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 9 High Q9JHJ0 Tropomodulin-3 OS=Mus musculus OX=10090 GN=Tmod3 PE=1 SV=1 0 188.131 59 21 186 20 352 39.5 5.14 17 21 21 43 70 73 251064357.4 655166689.1 989347445.3 24 26 25 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding Pf03250 50875 ENSMUSG00000058587.8 Tmod3 9 1 High B7FAV1 "Filamin, alpha (Fragment) OS=Mus musculus OX=10090 GN=Flna PE=1 SV=1" 0 332.597 40 70 182 62 2583 274.5 5.97 22 49 56 28 71 83 54556882.88 203938710.3 321470842.9 41 53 53 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding;signal transducer activity "Pf00307, Pf00630" 192176 ENSMUSG00000031328.15 Flna X 0 High Q3UW64 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Mus musculus OX=10090 GN=Gne PE=1 SV=1 0 324.087 60 40 182 40 753 82.8 7.05 35 35 90 92 2770591.766 440969945.3 572882443.1 5 43 44 metabolic process cytoplasm;cytosol catalytic activity;metal ion binding;nucleotide binding "Pf00370, Pf00480, Pf02350, Pf07085" 50798 ENSMUSG00000028479.18 Gne 4 0 High P13020 Gelsolin OS=Mus musculus OX=10090 GN=Gsn PE=1 SV=3 0 248.828 54 31 179 31 780 85.9 6.18 21 26 28 48 59 72 267042429 376325988.8 624265427.2 31 29 33 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus metal ion binding;protein binding Pf00626 227753 ENSMUSG00000026879.14 Gsn 2 Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Viral carcinogenesis 0 High A0A0A0MQF6 Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus OX=10090 GN=Gapdh PE=1 SV=1 0 209.698 64 19 178 19 359 38.6 8.97 15 18 19 29 70 79 121383295 430981720.6 684872065.3 24 26 26 cell death;cell organization and biogenesis;defense response;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00044, Pf02800" 14433 ENSMUSG00000057666.18 Gapdh 6 0 High Q8BMS1 "Trifunctional enzyme subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Hadha PE=1 SV=1" 0 281.716 65 37 175 37 763 82.6 9.14 33 29 32 60 52 63 230939047.1 240419588.1 325136126.1 37 37 38 metabolic process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00378, Pf00725, Pf02737" 97212 ENSMUSG00000025745.11 Hadha 5 Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; beta-Alanine metabolism; Propanoate metabolism; Fatty acid elongation; Carbon metabolism; Biosynthesis of unsaturated fatty acids" 0 High P17426 AP-2 complex subunit alpha-1 OS=Mus musculus OX=10090 GN=Ap2a1 PE=1 SV=1 0 230.154 58 45 174 33 977 107.6 7.03 28 39 35 47 67 60 84875464.05 159494292.6 222519747 32 34 33 regulation of biological process;transport membrane protein binding;transporter activity "Pf01602, Pf02296, Pf02883, Pf13646" 11771 ENSMUSG00000060279.14 Ap2a1 7 "WNT5A-dependent internalization of FZD4; Trafficking of GluR2-containing AMPA receptors; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Huntington's disease; Synaptic vesicle cycle 0 High O35643 AP-1 complex subunit beta-1 OS=Mus musculus OX=10090 GN=Ap1b1 PE=1 SV=2 0 209.683 50 42 162 17 943 103.9 5.17 27 34 30 47 57 58 17252350.17 32149631.25 32153984.19 13 16 15 cell organization and biogenesis;transport cytosol;Golgi;membrane protein binding;transporter activity "Pf01602, Pf02883, Pf09066, Pf12717, Pf13646" 11764 ENSMUSG00000009090.17 Ap1b1 11 MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis Lysosome 0 High P62814 "V-type proton ATPase subunit B, brain isoform OS=Mus musculus OX=10090 GN=Atp6v1b2 PE=1 SV=1" 0 255.822 74 28 155 21 511 56.5 5.81 17 28 24 24 72 59 47204107.39 219090933 298350439.8 29 32 32 metabolic process;transport cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;transporter activity "Pf00006, Pf00306, Pf02874" 11966 ENSMUSG00000006273.14 Atp6v1b2 8 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 7 High P50516 V-type proton ATPase catalytic subunit A OS=Mus musculus OX=10090 GN=Atp6v1a PE=1 SV=2 0 249.821 81 38 152 38 617 68.3 5.58 19 32 29 29 62 61 77321421.76 356537418.8 362739164.3 31 36 35 cellular homeostasis;metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;transporter activity "Pf00006, Pf00306, Pf02874" 11964 ENSMUSG00000052459.13 Atp6v1a 16 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High E9QNT8 Ankyrin-1 OS=Mus musculus OX=10090 GN=Ank1 PE=1 SV=1 0 313.742 44 54 152 50 1862 204.1 6.55 18 43 40 22 67 63 37051540.85 152629381.4 171867537.7 40 50 48 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;nucleus protein binding "Pf00023, Pf00531, Pf00791, Pf12796, Pf13606, Pf13637, Pf13857" 11733 ENSMUSG00000031543.18 Ank1 8 Proteoglycans in cancer 4 High Q6IRU2 Tropomyosin alpha-4 chain OS=Mus musculus OX=10090 GN=Tpm4 PE=1 SV=3 0 209.651 81 32 149 28 248 28.5 4.68 18 28 30 29 48 72 135778640.2 497492519.3 932707767 26 29 30 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis cytoplasm;cytoskeleton;membrane metal ion binding;protein binding;structural molecule activity "Pf00261, Pf12718" 326618 ENSMUSG00000031799.9 Tpm4 8 Striated Muscle Contraction; Smooth Muscle Contraction Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes 0 High P68372 Tubulin beta-4B chain OS=Mus musculus OX=10090 GN=Tubb4b PE=1 SV=1 0 174.726 67 23 145 1 445 49.8 4.89 14 18 23 37 50 58 89191540.23 256650217.8 381867934.4 21 22 23 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;RNA binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 227613 ENSMUSG00000036752.4 Tubb4b 2 Anchoring of the basal body to the plasma membrane; Intraflagellar transport; Hedgehog 'on' state; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Hedgehog 'off' state; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes Phagosome; Gap junction 24 High Q61554 Fibrillin-1 OS=Mus musculus OX=10090 GN=Fbn1 PE=1 SV=2 0 268.93 31 64 145 62 2873 312.1 4.92 21 41 47 22 53 70 60421439.84 163283125.9 239626544 49 58 56 metabolic process;regulation of biological process;response to stimulus cell surface;extracellular;membrane metal ion binding;protein binding;structural molecule activity "Pf00683, Pf06247, Pf07645, Pf12662, Pf12947, Pf14670" 14118 ENSMUSG00000027204.13 Fbn1 2 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Molecules associated with elastic fibres; Degradation of the extracellular matrix; Post-translational protein phosphorylation; Integrin cell surface interactions 2 High A2ARV4 Low-density lipoprotein receptor-related protein 2 OS=Mus musculus OX=10090 GN=Lrp2 PE=1 SV=1 0 289.845 19 72 143 72 4660 518.9 5.15 17 50 47 19 64 60 43234927.16 149948463.6 166376179.9 54 67 61 cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane;organelle lumen metal ion binding;protein binding;receptor activity;transporter activity "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670" 14725 ENSMUSG00000027070.14 Lrp2 2 Signaling by GPCR; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; Vitamin D (calciferol) metabolism Thyroid hormone synthesis; Hedgehog signaling pathway 0 High Q9CVB6 Actin-related protein 2/3 complex subunit 2 OS=Mus musculus OX=10090 GN=Arpc2 PE=1 SV=3 0 155.638 73 23 140 23 300 34.3 7.36 18 20 20 43 50 47 105567591.8 206529466.3 228124681.7 22 27 22 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;endosome;membrane protein binding;structural molecule activity Pf04045 76709 ENSMUSG00000006304.14 Arpc2 1 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High P31428 Dipeptidase 1 OS=Mus musculus OX=10090 GN=Dpep1 PE=1 SV=2 0 215.825 65 19 140 19 410 45.7 6.37 10 18 18 24 56 60 80588955.62 325712130.3 404244748.6 18 21 21 cell death;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;enzyme regulator activity;metal ion binding Pf01244 13479 ENSMUSG00000019278.5 Dpep1 8 Aflatoxin activation and detoxification; Synthesis of Leukotrienes (LT) and Eoxins (EX) 0 High Q99JY9 Actin-related protein 3 OS=Mus musculus OX=10090 GN=Actr3 PE=1 SV=3 0 167.987 72 20 138 18 418 47.3 5.88 19 20 20 40 46 52 217843160.3 368164421 396467121.5 24 24 24 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane nucleotide binding;protein binding;structural molecule activity Pf00022 74117 ENSMUSG00000026341.16 Actr3 1 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation 2 High Q03265 "ATP synthase subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1a PE=1 SV=1" 0 174.565 63 30 138 30 553 59.7 9.19 20 28 26 32 48 58 154526341.9 328562870.4 555207995.5 29 30 30 metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00006, Pf00306, Pf02663, Pf02874, Pf05943" 11946 ENSMUSG00000025428.15 Atp5a1 18 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P99024 Tubulin beta-5 chain OS=Mus musculus OX=10090 GN=Tubb5 PE=1 SV=1 0 168.835 68 23 135 3 444 49.6 4.89 14 19 23 33 51 51 10316246.81 19153153.31 27160696.91 5 5 5 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 22154 ENSMUSG00000001525.10 Tubb5 17 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes Phagosome; Gap junction 1 High Q9EQX4 Allograft inflammatory factor 1-like OS=Mus musculus OX=10090 GN=Aif1l PE=1 SV=1 0 79.669 63 11 133 11 150 17 7.18 9 10 11 25 58 50 119538876.8 398939600.9 435959710.7 13 14 13 Met-loss+Acetyl [N-Term] cytoplasm;cytoskeleton;membrane metal ion binding;protein binding Pf13499 108897 ENSMUSG00000001864.13 Aif1l 2 0 High Q60604 Adseverin OS=Mus musculus OX=10090 GN=Scin PE=1 SV=3 0 193.692 67 36 133 36 715 80.2 5.88 26 27 27 48 40 45 162089084.8 155687863.2 260202598.8 34 34 34 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton metal ion binding;protein binding Pf00626 20259 ENSMUSG00000002565.16 Scin 12 Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Viral carcinogenesis 0 High E9Q634 Unconventional myosin-Ie OS=Mus musculus OX=10090 GN=Myo1e PE=1 SV=1 0 205.282 43 41 131 34 1107 126.7 9.07 21 32 30 29 46 56 72030432.52 219716797.6 271313680 35 36 34 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00018, Pf00063, Pf06017, Pf07653, Pf14604" 71602 ENSMUSG00000032220.10 Myo1e 9 5 High Q9D6F9 Tubulin beta-4A chain OS=Mus musculus OX=10090 GN=Tubb4a PE=1 SV=3 0 159.251 61 20 129 1 444 49.6 4.88 12 16 20 32 45 52 5715049.5 9378667 12502456 1 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 22153 ENSMUSG00000062591.5 Tubb4a 17 Anchoring of the basal body to the plasma membrane; Intraflagellar transport; Hedgehog 'on' state; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Hedgehog 'off' state; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes Phagosome; Gap junction 0 High Q9CWF2 Tubulin beta-2B chain OS=Mus musculus OX=10090 GN=Tubb2b PE=1 SV=1 0 142.922 67 22 128 1 445 49.9 4.89 11 19 21 28 52 48 710382.75 1007394.625 1920064.75 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 73710 ENSMUSG00000045136.5 Tubb2b 13 Intraflagellar transport; Hedgehog 'on' state; Hedgehog 'off' state Phagosome; Gap junction 0 High Q7TMM9 Tubulin beta-2A chain OS=Mus musculus OX=10090 GN=Tubb2a PE=1 SV=1 0 145.779 67 22 128 1 445 49.9 4.89 11 19 21 28 52 48 5927860.5 15902715.13 20815799.75 4 5 5 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 22151 ENSMUSG00000058672.6 Tubb2a 13 Intraflagellar transport; Hedgehog 'on' state; Hedgehog 'off' state Phagosome; Gap junction 4 High P20029 Endoplasmic reticulum chaperone BiP OS=Mus musculus OX=10090 GN=Hspa5 PE=1 SV=3 0 174.431 52 35 127 33 655 72.4 5.16 18 32 21 23 70 34 181974625.4 227993137.4 111445214.2 26 34 31 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00012, Pf01968, Pf06723" 14828 ENSMUSG00000026864.13 Hspa5 2 Thyroid hormone synthesis; Antigen processing and presentation; Protein export; Prion diseases; Protein processing in endoplasmic reticulum 0 High Q9JJ28 Protein flightless-1 homolog OS=Mus musculus OX=10090 GN=Flii PE=1 SV=1 0 261.563 49 49 127 49 1271 144.7 6.06 16 31 42 18 47 62 44600574.2 135004871.8 210060256.7 36 42 46 Acetyl [N-Term] cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus protein binding "Pf00626, Pf12799, Pf13855" 14248 ENSMUSG00000002812.4 Flii 11 0 High P38647 "Stress-70 protein, mitochondrial OS=Mus musculus OX=10090 GN=Hspa9 PE=1 SV=3" 0 163.125 50 30 126 30 679 73.4 6.07 26 25 25 41 42 43 126051155.3 193586913.5 239691361.2 27 28 27 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;mitochondrion;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00012, Pf06723" 15526 ENSMUSG00000024359.8 Hspa9 18 RNA degradation; Tuberculosis 0 High Q8VEH8 Endoplasmic reticulum lectin 1 OS=Mus musculus OX=10090 GN=Erlec1 PE=1 SV=1 0 246.8 76 27 125 27 483 54.9 6.25 23 24 61 64 43853662.73 627961242.7 755973411.3 8 30 32 metabolic process;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 66753 ENSMUSG00000020311.17 Erlec1 11 Hedgehog ligand biogenesis; ABC-family proteins mediated transport Protein processing in endoplasmic reticulum 0 High Q3TWV4 AP-2 complex subunit mu OS=Mus musculus OX=10090 GN=Ap2m1 PE=1 SV=1 0 145.322 58 25 122 23 433 49.4 9.54 21 22 19 37 46 39 155840615 327443742.7 406966869.6 24 24 24 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion protein binding Pf00928 11773 ENSMUSG00000022841.14 Ap2m1 16 2 High Q9QXS1 Plectin OS=Mus musculus OX=10090 GN=Plec PE=1 SV=3 0 284.615 21 79 118 76 4691 533.9 5.96 12 56 39 12 62 44 38167709.63 138663690.3 100254874.4 50 66 57 cell organization and biogenesis;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00307, Pf00681, Pf03501, Pf07812, Pf11971" 18810 ENSMUSG00000022565.15 Plec 15 Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins; Assembly of collagen fibrils and other multimeric structures 2 High P97479 Unconventional myosin-VIIa OS=Mus musculus OX=10090 GN=Myo7a PE=1 SV=2 0 214.963 24 45 118 43 2215 254.8 8.54 19 35 33 26 46 46 54644357.05 131939119.7 217613286.1 30 40 39 cell differentiation;cell organization and biogenesis;cellular component movement;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00373, Pf00612, Pf00784" 17921 ENSMUSG00000030761.15 Myo7a 7 The canonical retinoid cycle in rods (twilight vision); Signaling by GPCR 0 High P61161 Actin-related protein 2 OS=Mus musculus OX=10090 GN=Actr2 PE=1 SV=1 0 137.957 53 16 117 16 394 44.7 6.74 11 15 15 30 41 46 137451640 210461193.9 249763143.4 20 19 21 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane nucleotide binding;protein binding;structural molecule activity Pf00022 66713 ENSMUSG00000020152.7 Actr2 11 RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation 0 High Q99KI0 "Aconitate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Aco2 PE=1 SV=1" 0 172.182 46 30 112 30 780 85.4 7.93 16 25 27 23 43 46 108915477.9 239453699.5 302119161.1 27 29 31 metabolic process;response to stimulus mitochondrion catalytic activity;metal ion binding "Pf00330, Pf00694" 11429 ENSMUSG00000022477.12 Aco2 15 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High B1ARU4 Microtubule-actin cross-linking factor 1 OS=Mus musculus OX=10090 GN=Macf1 PE=1 SV=1 0 294.229 13 71 109 1 7353 831.1 5.41 4 40 57 4 42 63 21037828.68 64125825.75 116251691.7 41 52 59 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane catalytic activity;metal ion binding;motor activity;protein binding "Pf00036, Pf00307, Pf00435, Pf00681, Pf01576, Pf02187, Pf02463, Pf03938, Pf11971, Pf13499, Pf13514, Pf13833" 11426 ENSMUSG00000028649.17 Macf1 4 63 High F7ACR9 Microtubule-actin cross-linking factor 1 (Fragment) OS=Mus musculus OX=10090 GN=Macf1 PE=1 SV=1 0 291.979 18 71 109 1 5333 607.9 5.4 4 40 57 4 42 63 473787.4375 1984551 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf00036, Pf00307, Pf00435, Pf02187, Pf02463, Pf03938, Pf11971, Pf13499, Pf13833" 442834; 11426 ENSMUSG00000028649.17 D830031N03Rik; Macf1 4 0 High A0A0A0MQA5 Tubulin alpha chain (Fragment) OS=Mus musculus OX=10090 GN=Tuba4a PE=1 SV=1 0 155.823 53 19 108 8 477 52.9 5.19 15 17 17 20 37 51 50677052.77 123871575.7 187282558.3 16 18 19 cell organization and biogenesis catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" ENSMUSG00000026202.13 1 12 High G5E8R3 Pyruvate carboxylase OS=Mus musculus OX=10090 GN=Pcx PE=1 SV=1 0 197.259 45 35 103 35 1178 129.6 6.71 14 27 29 18 38 47 27937391.19 89605740.31 144676329.4 24 28 31 metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf00682, Pf02222, Pf02436, Pf02785, Pf02786, Pf07478, Pf08443, Pf13533, Pf13535, Pf15632" 18563 ENSMUSG00000024892.15 Pcx 19 Biotin transport and metabolism; Gluconeogenesis 0 High P68373 Tubulin alpha-1C chain OS=Mus musculus OX=10090 GN=Tuba1c PE=1 SV=1 0 133.519 56 18 99 7 449 49.9 5.1 14 16 17 19 33 47 23174046.31 71493810.75 68848942.63 5 6 6 cell organization and biogenesis cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953" 22146 ENSMUSG00000043091.8 Tuba1c 15 Intraflagellar transport; Hedgehog 'on' state; Hedgehog 'off' state Phagosome; Gap junction; Apoptosis 0 High Q60847 Collagen alpha-1(XII) chain OS=Mus musculus OX=10090 GN=Col12a1 PE=2 SV=3 0 128.944 15 36 96 36 3120 340 5.64 28 23 20 35 35 26 59763451.97 77856687.66 81697602.53 30 33 30 cell differentiation extracellular protein binding "Pf00041, Pf00092, Pf13519" 12816 Col12a1 9 Collagen chain trimerization; Collagen degradation; Assembly of collagen fibrils and other multimeric structures Protein digestion and absorption 0 High Q8K010 5-oxoprolinase OS=Mus musculus OX=10090 GN=Oplah PE=1 SV=1 0 224.124 47 40 96 40 1288 137.5 6.28 38 27 59 37 13281772.24 212630543 202094179.9 17 37 38 metabolic process cytosol catalytic activity;nucleotide binding "Pf01968, Pf02538, Pf05378" 75475 ENSMUSG00000022562.14 Oplah 15 Glutathione synthesis and recycling Glutathione metabolism 0 High Q99JY0 "Trifunctional enzyme subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Hadhb PE=1 SV=1" 0 118.994 60 24 95 24 475 51.4 9.38 20 21 20 37 31 27 96165383.42 132224920.2 167283485.9 23 23 22 metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00108, Pf00109, Pf02803" 231086 ENSMUSG00000059447.13 Hadhb 5 Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; Fatty acid elongation" 0 High P35700 Peroxiredoxin-1 OS=Mus musculus OX=10090 GN=Prdx1 PE=1 SV=1 0 101.405 86 17 94 17 199 22.2 8.12 11 13 16 22 30 42 85309676.66 229238148.4 402581038.6 17 16 17 cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00578, Pf08534, Pf10417" 18477 ENSMUSG00000028691.12 Prdx1 4 Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes Peroxisome 0 High Q9ERG0 LIM domain and actin-binding protein 1 OS=Mus musculus OX=10090 GN=Lima1 PE=1 SV=3 0 139.491 47 29 93 29 753 84 6.6 16 28 19 18 48 27 46395360.31 215337108.4 215265374.3 25 29 27 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton metal ion binding;protein binding Pf00412 65970 ENSMUSG00000023022.13 Lima1 15 0 High A0A0R4J1E3 Drebrin OS=Mus musculus OX=10090 GN=Dbn1 PE=1 SV=1 0 117.909 35 22 93 15 661 72.5 4.44 16 20 16 22 39 32 71154289.73 226934060.7 303219623.5 23 20 22 Met-loss+Acetyl [N-Term] cell communication;cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane protein binding Pf00241 56320 ENSMUSG00000034675.17 Dbn1 13 7 High P58252 Elongation factor 2 OS=Mus musculus OX=10090 GN=Eef2 PE=1 SV=2 0 187.606 52 35 93 35 858 95.3 6.83 12 27 30 12 34 47 18886796.56 101402107.3 159788291.1 29 33 34 Met-loss [N-Term] cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 13629 ENSMUSG00000034994.10 Eef2 10 Peptide chain elongation; Neutrophil degranulation; Protein methylation; Synthesis of diphthamide-EEF2 Oxytocin signaling pathway; AMPK signaling pathway 0 High Q8VDN2 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Mus musculus OX=10090 GN=Atp1a1 PE=1 SV=1 0 162.881 36 30 89 30 1023 112.9 5.45 15 26 21 18 38 33 41333054.91 101299628.3 122666249.3 27 27 28 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 11928 ENSMUSG00000033161.10 Atp1a1 3 Ion transport by P-type ATPases; Ion homeostasis Pancreatic secretion; Carbohydrate digestion and absorption; Mineral absorption; Protein digestion and absorption; Endocrine and other factor-regulated calcium reabsorption; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Proximal tubule bicarbonate reclamation; cGMP-PKG signaling pathway; Bile secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Gastric acid secretion; Insulin secretion; Adrenergic signaling in cardiomyocytes; Aldosterone-regulated sodium reabsorption 0 High P20152 Vimentin OS=Mus musculus OX=10090 GN=Vim PE=1 SV=3 0 114.838 56 28 89 22 466 53.7 5.12 11 27 24 15 42 32 39915244.5 134637876.6 154456742 26 28 27 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186" 22352 ENSMUSG00000026728.9 Vim 2 Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins MicroRNAs in cancer; Epstein-Barr virus infection 6 High P09242 "Alkaline phosphatase, tissue-nonspecific isozyme OS=Mus musculus OX=10090 GN=Alpl PE=1 SV=2" 0 135.177 54 21 84 21 524 57.5 7.01 11 19 18 15 37 32 43000585.61 124935884.9 143773494.3 16 19 21 cell differentiation;metabolic process;response to stimulus membrane catalytic activity;metal ion binding;protein binding Pf00245 11647 ENSMUSG00000028766.10 Alpl 4 Post-translational modification: synthesis of GPI-anchored proteins Thiamine metabolism; Metabolic pathways; Folate biosynthesis 0 High Q61194 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Mus musculus OX=10090 GN=Pik3c2a PE=1 SV=2 0 174.455 37 43 84 43 1686 190.6 8.02 10 31 31 10 37 37 28234370.91 66362286.25 102706309.8 28 36 37 cell communication;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794, Pf04621" 18704 Pik3c2a 7 Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system 0 High Q9DCL9 Multifunctional protein ADE2 OS=Mus musculus OX=10090 GN=Paics PE=1 SV=4 0 133.206 69 25 84 25 425 47 7.23 2 22 19 2 46 36 8515855.188 276524516.5 216976606.4 8 25 25 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;membrane catalytic activity;nucleotide binding;protein binding "Pf00731, Pf01259" 67054 ENSMUSG00000029247.17 Paics 5 Purine ribonucleoside monophosphate biosynthesis Metabolic pathways; Purine metabolism 0 High O35488 Very long-chain acyl-CoA synthetase OS=Mus musculus OX=10090 GN=Slc27a2 PE=1 SV=2 0 163.11 52 31 84 31 620 70.4 8.9 11 23 27 14 31 39 19903890.65 83052182 99506412.81 16 27 26 metabolic process;transport endoplasmic reticulum;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00501, Pf13193" 26458 ENSMUSG00000027359.16 Slc27a2 2 Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Neutrophil degranulation; Synthesis of bile acids and bile salts via 24-hydroxycholesterol PPAR signaling pathway; Insulin resistance; Peroxisome 0 High E9QAT4 Protein transport protein Sec16A OS=Mus musculus OX=10090 GN=Sec16a PE=1 SV=1 0 172.251 16 25 81 25 2357 254 5.81 16 19 19 19 27 35 35348499.74 70791966.91 102640580.1 20 22 23 cell organization and biogenesis;transport cytosol;endoplasmic reticulum;Golgi;membrane catalytic activity "Pf10697, Pf12931, Pf12932" 227648 ENSMUSG00000026924.17 Sec16a 2 COPII (Coat Protein 2) Mediated Vesicle Transport 0 High Q80X19 Collagen alpha-1(XIV) chain OS=Mus musculus OX=10090 GN=Col14a1 PE=1 SV=2 0 156.478 29 36 81 36 1797 192.9 5.1 19 21 23 24 26 31 38557683.02 59225512.27 82475782.19 31 31 29 cell organization and biogenesis;regulation of biological process extracellular protein binding;RNA binding "Pf00041, Pf00092, Pf01391, Pf13519" 12818 ENSMUSG00000022371.15 Col14a1 15 Collagen chain trimerization; Assembly of collagen fibrils and other multimeric structures 0 High Q9DBM2 Peroxisomal bifunctional enzyme OS=Mus musculus OX=10090 GN=Ehhadh PE=1 SV=4 0 162.992 67 33 80 33 718 78.3 9.13 6 26 25 7 35 38 13804421.55 71893909.25 101699509.7 21 31 27 metabolic process;transport cytosol;mitochondrion catalytic activity;protein binding "Pf00378, Pf00725, Pf02254, Pf02737" 74147 ENSMUSG00000022853.6 Ehhadh 16 Beta-oxidation of very long chain fatty acids "PPAR signaling pathway; Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; beta-Alanine metabolism; Propanoate metabolism; Carbon metabolism; Peroxisome" 0 High Q6ZWQ0 Nesprin-2 OS=Mus musculus OX=10090 GN=Syne2 PE=1 SV=2 0 165.599 7 35 80 35 6874 782.2 5.33 5 26 25 5 35 40 12300259.59 70622727.78 100404075.6 18 30 31 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen protein binding "Pf00307, Pf00435, Pf10541, Pf11971" 319565 ENSMUSG00000063450.14 Syne2 12 Mus musculus biological processes; Meiotic Synapsis 0 High Q9EQK5 Major vault protein OS=Mus musculus OX=10090 GN=Mvp PE=1 SV=4 0 135.685 47 27 78 27 861 95.9 5.59 17 19 22 20 25 33 47886187.56 68106189.25 101658230.5 23 24 25 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding "Pf01145, Pf01505, Pf11978" 78388 Mvp 7 0 High P56480 "ATP synthase subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1b PE=1 SV=2" 0 143.04 61 22 75 22 529 56.3 5.34 11 15 20 12 23 40 69920415.91 1102223069 1564920351 19 19 23 cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;transport cell surface;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity;transporter activity "Pf00006, Pf00306, Pf02874" 11947 ENSMUSG00000025393.12 Atp5b 10 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q9WUM4 Coronin-1C OS=Mus musculus OX=10090 GN=Coro1c PE=1 SV=2 0 108.563 46 20 75 20 474 53.1 7.08 15 20 18 22 28 25 44522697.13 108232887.4 128778016.9 19 17 18 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;membrane protein binding "Pf00400, Pf08953, Pf08954" 23790 ENSMUSG00000004530.12 Coro1c 5 0 High Q99LB2 Dehydrogenase/reductase SDR family member 4 OS=Mus musculus OX=10090 GN=Dhrs4 PE=1 SV=3 0 88.509 57 16 75 16 279 29.9 9.38 9 13 14 15 23 37 40543812.31 161038146.8 409177272.4 12 16 15 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf00106, Pf08659, Pf13561" 28200 ENSMUSG00000022210.6 Dhrs4 14 RA biosynthesis pathway Retinol metabolism; Metabolic pathways; Peroxisome 0 High Q5SV80 Unconventional myosin-XIX OS=Mus musculus OX=10090 GN=Myo19 PE=1 SV=1 0 171.361 45 27 73 27 963 108 7.9 10 19 21 11 24 38 21022934.57 63695705.66 100049297.6 24 27 24 Acetyl [N-Term] cellular component movement;regulation of biological process cytoplasm;cytoskeleton;membrane;mitochondrion catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00612" 66196 ENSMUSG00000020527.14 Myo19 11 0 High Q6PFA2 Clathrin light chain OS=Mus musculus OX=10090 GN=Clta PE=1 SV=1 0 48.514 40 12 72 12 218 23.6 4.5 10 11 12 17 25 30 239370027.9 469959292 703255820.8 13 12 13 cell division;cell organization and biogenesis;transport cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity Pf01086 12757 ENSMUSG00000028478.18 Clta 4 "WNT5A-dependent internalization of FZD4; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Lysosome; Huntington's disease; Synaptic vesicle cycle; Bacterial invasion of epithelial cells 0 High P04919 Band 3 anion transport protein OS=Mus musculus OX=10090 GN=Slc4a1 PE=1 SV=1 0 118.16 26 17 72 17 929 103.1 5.45 6 16 14 7 33 32 20572707.12 87029698.91 91566588 16 19 18 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cell surface;cytoskeleton;membrane protein binding;transporter activity "Pf00955, Pf07565" 20533 ENSMUSG00000006574.15 Slc4a1 11 Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Bicarbonate transporters Collecting duct acid secretion 0 High Q04857 Collagen alpha-1(VI) chain OS=Mus musculus OX=10090 GN=Col6a1 PE=1 SV=1 0 127.132 33 23 71 23 1025 108.4 5.36 9 19 17 10 29 32 21026544.84 63361739.78 108317723.8 19 20 20 cell differentiation;cell organization and biogenesis;response to stimulus extracellular;membrane protein binding "Pf00092, Pf01391, Pf13519, Pf13768" 12833 ENSMUSG00000001119.7 Col6a1 10 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures Focal adhesion; Protein digestion and absorption; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q02788 Collagen alpha-2(VI) chain OS=Mus musculus OX=10090 GN=Col6a2 PE=1 SV=3 0 108.614 25 20 70 20 1034 110.3 6.42 10 17 17 13 25 32 21410875.09 66095532.91 127243082.8 15 21 21 cell organization and biogenesis;response to stimulus extracellular;membrane "Pf00092, Pf01391, Pf13519" 12834 ENSMUSG00000020241.13 Col6a2 10 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures Focal adhesion; Protein digestion and absorption; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High G5E8C6 Villin-like protein OS=Mus musculus OX=10090 GN=Vill PE=1 SV=1 0 139.648 43 27 70 27 859 96.5 6.35 5 23 23 5 34 31 19025220.91 136910385.3 164244602.8 18 28 26 Acetyl [N-Term] cell organization and biogenesis;regulation of biological process protein binding "Pf00626, Pf02209" 22351 ENSMUSG00000038775.14 Vill 9 0 High Q62167 ATP-dependent RNA helicase DDX3X OS=Mus musculus OX=10090 GN=Ddx3x PE=1 SV=3 0 98.265 46 26 70 25 662 73.1 7.18 11 20 20 13 27 30 16170628.2 48788323.83 74636521.16 18 24 24 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 13205 ENSMUSG00000000787.12 Ddx3x X Neutrophil degranulation RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis 1 High A0A140LI54 Neuropathy target esterase OS=Mus musculus OX=10090 GN=Pnpla6 PE=1 SV=1 0 184.737 34 35 69 32 1345 148.6 7.74 30 18 44 25 3523430.078 92713335.66 74290913.38 11 33 26 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00027, Pf01734" 50767 ENSMUSG00000004565.15 Pnpla6 8 Glycerophospholipid metabolism 3 High P51881 ADP/ATP translocase 2 OS=Mus musculus OX=10090 GN=Slc25a5 PE=1 SV=3 0 49.599 52 14 69 7 298 32.9 9.73 12 12 13 21 24 24 65604584.28 120019028.9 124033747.3 15 15 13 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;RNA binding;transporter activity Pf00153 11740 ENSMUSG00000016319.3 Slc25a5 X Regulation of insulin secretion HTLV-I infection; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway 8 High B1B0C7 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Mus musculus OX=10090 GN=Hspg2 PE=1 SV=1 0 155.66 15 41 69 41 4375 468.7 6.48 22 19 27 23 19 27 28755223.67 32452752.86 45274458.47 27 27 25 cell differentiation;cell organization and biogenesis;transport extracellular metal ion binding;protein binding "Pf00008, Pf00047, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf07686, Pf12785, Pf13385, Pf13895, Pf13927" 15530 ENSMUSG00000028763.17 Hspg2 4 HS-GAG degradation; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Signaling by GPCR; Retinoid metabolism and transport; Integrin cell surface interactions; HS-GAG biosynthesis; Non-integrin membrane-ECM interactions 0 High P21981 Protein-glutamine gamma-glutamyltransferase 2 OS=Mus musculus OX=10090 GN=Tgm2 PE=1 SV=4 0 116.619 44 22 69 22 686 77 5.1 10 16 19 16 24 29 31197470.9 61030264.34 92352395.19 20 20 20 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00868, Pf00927, Pf01841" 21817 ENSMUSG00000037820.15 Tgm2 2 Huntington's disease 0 High Q91YH6 Vacuolar proton pump subunit B OS=Mus musculus OX=10090 GN=Atp6v1b1 PE=1 SV=1 0 130.952 60 19 68 12 513 56.8 5.34 7 17 14 10 32 26 9323232.188 30436928.31 40554805.5 7 9 9 metabolic process;transport cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00006, Pf00306, Pf02874" 110935 ENSMUSG00000006269.7 Atp6v1b1 6 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High P20918 Plasminogen OS=Mus musculus OX=10090 GN=Plg PE=1 SV=3 0 117.986 52 29 67 29 812 90.7 6.6 4 29 10 4 51 12 7686535.275 100054805.6 47178569.02 18 28 22 cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;coagulation;metabolic process;regulation of biological process cell surface;extracellular;membrane catalytic activity;protein binding "Pf00024, Pf00051, Pf00089, Pf09342, Pf13365" 18815 ENSMUSG00000059481.4 Plg 17 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); LDL remodeling; Plasma lipoprotein remodeling; Dissolution of Fibrin Clot; Platelet degranulation ; Signaling by PDGF; Activation of Matrix Metalloproteinases Staphylococcus aureus infection; Complement and coagulation cascades; Influenza A; Neuroactive ligand-receptor interaction 0 High P53395 "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dbt PE=1 SV=2" 0 68.028 44 17 67 17 482 53.2 8.6 12 13 12 24 26 17 41075344.84 62843790.38 79740555.75 16 16 16 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 13171 ENSMUSG00000000340.10 Dbt 3 Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism" 0 High Q920R6 V-type proton ATPase 116 kDa subunit a isoform 4 OS=Mus musculus OX=10090 GN=Atp6v0a4 PE=1 SV=1 0 110.365 30 20 66 20 833 95.5 6.35 12 17 11 16 31 19 639916528.4 95836812.22 98264315.63 19 19 18 cell organization and biogenesis;cellular homeostasis;metabolic process;transport endosome;membrane catalytic activity;protein binding;transporter activity "Pf01496, Pf13965" 140494 ENSMUSG00000038600.12 Atp6v0a4 6 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Lysosome; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High A0A1C7CYV0 Plastin-3 (Fragment) OS=Mus musculus OX=10090 GN=Pls3 PE=1 SV=1 0 164.187 60 27 66 22 629 70.6 5.62 2 21 20 2 28 36 9595767.953 93809648.5 144839880.4 16 23 23 Acetyl [N-Term] metal ion binding;protein binding "Pf00307, Pf13499" ENSMUSG00000016382.15 X 5 High Q925I1 ATPase family AAA domain-containing protein 3 OS=Mus musculus OX=10090 GN=Atad3 PE=1 SV=1 0 104.529 49 25 66 25 591 66.7 9.29 17 14 16 24 19 23 60993056.03 79872343.13 81560645.17 24 23 22 cell growth;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401" 108888 ENSMUSG00000029036.18 Atad3a 4 Neutrophil degranulation 0 High Q9D6P8 Calmodulin-like protein 3 OS=Mus musculus OX=10090 GN=Calml3 PE=2 SV=1 0 44.587 50 8 66 1 149 16.7 4.31 7 7 8 16 23 27 Met-loss+Acetyl [N-Term] metal ion binding "Pf00036, Pf08726, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658" 70405 ENSMUSG00000063130.3 Calml3 13 Oxytocin signaling pathway; Dopaminergic synapse; Ras signaling pathway; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Tuberculosis; Melanogenesis; Oocyte meiosis; Pertussis; Neurotrophin signaling pathway; cGMP-PKG signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Olfactory transduction; Phototransduction; Gastric acid secretion; Renin secretion; Circadian entrainment; Glioma; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 0 High Q80YE7 Death-associated protein kinase 1 OS=Mus musculus OX=10090 GN=Dapk1 PE=1 SV=3 0 127.728 30 29 65 29 1442 161.3 6.89 8 22 19 9 28 28 17502456.43 67012153.42 104315231.2 18 27 23 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00023, Pf00069, Pf00531, Pf07714, Pf12796, Pf13606, Pf13637, Pf13857" 69635 Dapk1 13 Pathways in cancer; Bladder cancer 0 High P10126 Elongation factor 1-alpha 1 OS=Mus musculus OX=10090 GN=Eef1a1 PE=1 SV=3 0 90.465 46 15 65 15 462 50.1 9.01 8 13 15 13 23 29 45969813.34 129897904.6 167276084.6 13 15 14 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 13627 ENSMUSG00000037742.14 Eef1a1; LOC101056619 9 Legionellosis; RNA transport 0 High Q91VB8 Alpha globin 1 OS=Mus musculus OX=10090 GN=Hba-a1 PE=1 SV=1 0 95.595 82 8 65 8 142 15.1 8.22 7 8 8 15 22 28 47657013.75 102269329.9 164738900.5 8 9 9 response to stimulus;transport membrane antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 15122; 110257 ENSMUSG00000069919.7; ENSMUSG00000069917.7 Hba-a1; Hba-a2 11 Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Scavenging of heme from plasma African trypanosomiasis; Malaria 0 High Q61696 Heat shock 70 kDa protein 1A OS=Mus musculus OX=10090 GN=Hspa1a PE=1 SV=2 0 85.32 38 21 65 16 641 70 5.72 11 14 17 17 21 27 26995677.25 39685634.63 44245108.25 14 14 12 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00012, Pf06723" 193740; 15511 ENSMUSG00000091971.3 Hspa1a; Hspa1b 17 Endocytosis; MAPK signaling pathway; Toxoplasmosis; Epstein-Barr virus infection; Spliceosome; Legionellosis; Influenza A; Antigen processing and presentation; Prion diseases; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Measles; Longevity regulating pathway - multiple species 0 High Q3U7K7 E3 ubiquitin-protein ligase TRIM21 OS=Mus musculus OX=10090 GN=Trim21 PE=1 SV=1 0 74.525 45 18 65 18 462 53.3 6.7 12 14 16 17 24 24 60129290.31 108231877.7 116241021.6 15 16 16 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227" 20821 ENSMUSG00000030966.13 Trim21 7 Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA Systemic lupus erythematosus 0 High Q6P4T2 U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Mus musculus OX=10090 GN=Snrnp200 PE=1 SV=1 0 161.593 23 33 65 33 2136 244.4 6.06 25 26 31 34 2306600.76 38599251.66 39750199.94 10 27 28 cell differentiation;metabolic process membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02889, Pf04851" 320632 ENSMUSG00000003660.10 Snrnp200 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q3UQ44 Ras GTPase-activating-like protein IQGAP2 OS=Mus musculus OX=10090 GN=Iqgap2 PE=1 SV=2 0 123.318 27 31 64 26 1575 180.4 5.64 6 17 23 8 25 31 3682787.563 21477721.63 31084714.5 9 21 19 cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;cytoplasm protein binding "Pf00307, Pf00616, Pf03836" 544963 ENSMUSG00000021676.9 Iqgap2 13 RHO GTPases activate IQGAPs; Neutrophil degranulation Regulation of actin cytoskeleton 0 High Q9D2G2 "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dlst PE=1 SV=1" 0 61.654 28 10 63 10 454 49 8.95 9 8 10 17 20 26 109363278.3 208254617.5 420600392.3 10 11 11 metabolic process membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf00198, Pf00364" 78920 ENSMUSG00000004789.9 Dlst 12 Lysine catabolism; Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); Metabolic pathways; Lysine degradation; Carbon metabolism 0 High G5E8K5 Ankyrin-3 OS=Mus musculus OX=10090 GN=Ank3 PE=1 SV=1 0 134.646 20 30 63 24 1961 213.9 6.7 6 23 18 7 29 27 11315803.48 57338860.31 62528586.69 16 22 20 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;vacuole protein binding;structural molecule activity "Pf00023, Pf00531, Pf00791, Pf12796, Pf13606, Pf13637, Pf13857" 11735 ENSMUSG00000069601.14 Ank3 10 COPI-mediated anterograde transport Proteoglycans in cancer 2 High Q60597 "2-oxoglutarate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Ogdh PE=1 SV=3" 0 120.57 42 28 62 28 1023 116.4 6.83 16 16 19 17 21 24 40900146.42 68757465.13 58814538.63 22 22 21 cellular component movement;metabolic process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00676, Pf02779" 18293 ENSMUSG00000020456.17 Ogdh 11 Lysine catabolism; Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation Tryptophan metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Lysine degradation; Carbon metabolism 0 High P07724 Serum albumin OS=Mus musculus OX=10090 GN=Alb PE=1 SV=3 0 98.038 54 24 61 24 608 68.6 6.07 11 21 12 14 32 15 30316067.52 90238931.38 56377459.13 22 22 18 cell communication;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus DNA binding;metal ion binding;protein binding Pf00273 11657 ENSMUSG00000029368.10 Alb 5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Platelet degranulation ; Transport of organic anions; HDL remodeling; Scavenging of heme from plasma Thyroid hormone synthesis 0 High Q8BWT1 "3-ketoacyl-CoA thiolase, mitochondrial OS=Mus musculus OX=10090 GN=Acaa2 PE=1 SV=3" 0 84.585 68 17 61 17 397 41.8 8.09 12 12 16 18 21 22 41350433.81 68946953.13 114476426.4 15 14 16 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;RNA binding "Pf00108, Pf02801, Pf02803" 52538 ENSMUSG00000036880.9 Acaa2 18 Mitochondrial Fatty Acid Beta-Oxidation "Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; Fatty acid elongation" 0 High Q8BH44 Coronin-2B OS=Mus musculus OX=10090 GN=Coro2b PE=1 SV=2 0 89.858 49 19 60 19 480 54.9 8.27 10 12 18 11 17 32 23984012.03 78118379 135761952.5 16 18 19 cell organization and biogenesis cytoplasm;cytoskeleton;membrane protein binding "Pf00400, Pf08953, Pf08954" 235431 ENSMUSG00000041729.15 Coro2b 9 0 High D3YZ62 Unconventional myosin-Va OS=Mus musculus OX=10090 GN=Myo5a PE=1 SV=1 0 98.997 17 26 60 16 1828 212.2 8.62 10 19 20 14 24 22 5115784.391 12147539.56 16445728.25 10 11 12 cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;vacuole catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;RNA binding "Pf00063, Pf00261, Pf00612, Pf00769, Pf01442, Pf01843, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf06548, Pf06705, Pf07028, Pf07888, Pf07926, Pf08317, Pf09311, Pf09726, Pf10174, Pf12128" 17918 ENSMUSG00000034593.16 Myo5a 9 0 High F7CUP3 N-acetylglucosamine-6-phosphate deacetylase OS=Mus musculus OX=10090 GN=Amdhd2 PE=1 SV=2 0 139.526 64 16 58 16 446 47.1 6.87 15 14 30 28 566155.2891 59420626.06 57219220.75 4 15 15 0 High O08648 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus OX=10090 GN=Map3k4 PE=1 SV=2 0 143.848 23 30 58 30 1597 179.7 6.43 26 20 34 24 2052817.162 72256463.59 62844501.25 5 28 26 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf07714, Pf14531" 26407 ENSMUSG00000014426.8 Map3k4 17 MAPK signaling pathway; GnRH signaling pathway 0 High Q6IRU5 Clathrin light chain B OS=Mus musculus OX=10090 GN=Cltb PE=1 SV=1 0 35.663 29 10 57 3 229 25.2 4.63 7 10 9 13 25 19 192383944.4 400355687 540139663 10 10 10 transport cytosol;membrane protein binding;structural molecule activity Pf01086 74325 ENSMUSG00000047547.14 Cltb 13 "WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Lysosome Vesicle Biogenesis; Formation of annular gap junctions; Cargo recognition for clathrin-mediated endocytosis" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Lysosome; Huntington's disease; Synaptic vesicle cycle; Bacterial invasion of epithelial cells 7 High P26231 Catenin alpha-1 OS=Mus musculus OX=10090 GN=Ctnna1 PE=1 SV=1 0 137.973 45 29 57 23 906 100 6.23 16 14 22 17 17 23 30155084.77 34047354.91 58531511.72 23 24 25 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;Golgi;membrane protein binding;RNA binding;structural molecule activity Pf01044 12385 ENSMUSG00000037815.6 Ctnna1 18 VEGFR2 mediated vascular permeability; RHO GTPases activate IQGAPs; Adherens junctions interactions; CDO in myogenesis Leukocyte transendothelial migration; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Endometrial cancer; Hippo signaling pathway; Adherens junction; Pathways in cancer; Tight junction; Bacterial invasion of epithelial cells 6 High Q9R0Q6 Actin-related protein 2/3 complex subunit 1A OS=Mus musculus OX=10090 GN=Arpc1a PE=1 SV=1 0 80.554 63 19 57 19 370 41.6 8.18 14 12 15 19 16 22 55438381.63 57077871.47 100820263.3 15 15 19 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding Pf00400 56443 ENSMUSG00000029621.14 Arpc1a 5 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High F6XCT0 Microtubule-actin cross-linking factor 1 (Fragment) OS=Mus musculus OX=10090 GN=Macf1 PE=1 SV=1 0 149.513 26 37 56 1 1837 211.6 5.73 3 20 27 3 21 32 660612.625 877216.25 1891061 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf00307, Pf02463, Pf03938, Pf11971, Pf13514" 11426 ENSMUSG00000028649.17 Macf1 4 0 High P01027 Complement C3 OS=Mus musculus OX=10090 GN=C3 PE=1 SV=3 0 82.549 18 24 56 24 1663 186.4 6.73 17 12 13 28 14 14 66521503.91 66198935.16 76392491.06 21 20 17 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974" 12266 ENSMUSG00000024164.15 C3 17 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Regulation of Complement cascade; Peptide ligand-binding receptors; G alpha (i) signalling events; Activation of C3 and C5; Post-translational protein phosphorylation; Alternative complement activation; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Herpes simplex infection; Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Tuberculosis; Phagosome; Complement and coagulation cascades; Pertussis; Legionellosis; Systemic lupus erythematosus; Leishmaniasis; Viral carcinogenesis 0 High O88428 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Mus musculus OX=10090 GN=Papss2 PE=1 SV=2 0 139.075 56 23 55 23 621 70.3 7.58 9 17 17 9 20 26 14010776.42 59185315 77952990.06 17 20 23 coagulation;metabolic process catalytic activity;nucleotide binding "Pf01583, Pf01747, Pf13207, Pf13238, Pf13671, Pf14306" 23972 ENSMUSG00000024899.6 Papss2 19 Transport and synthesis of PAPS Metabolic pathways; Purine metabolism; Sulfur metabolism; Selenocompound metabolism 0 High A2A9M4 Dedicator of cytokinesis protein 7 OS=Mus musculus OX=10090 GN=Dock7 PE=1 SV=2 0 108.787 23 32 55 30 2130 241.3 6.76 6 20 23 6 23 26 42602354.27 89136352.41 77671624.88 19 25 21 cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus protein binding "Pf06920, Pf11878, Pf14429" 67299 ENSMUSG00000028556.15 Dock7 4 MET activates RAP1 and RAC1 2 High P59999 Actin-related protein 2/3 complex subunit 4 OS=Mus musculus OX=10090 GN=Arpc4 PE=1 SV=3 0 89.993 73 10 55 10 168 19.7 8.43 8 8 10 18 17 20 77184537.9 133667042.8 163615379.3 11 14 14 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding;structural molecule activity Pf05856 68089 ENSMUSG00000079426.13 Arpc4 6 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High A8DUK4 Beta-globin OS=Mus musculus OX=10090 GN=Hbb-bs PE=1 SV=1 0 61.644 71 11 54 11 147 15.7 7.69 9 9 10 15 19 20 56046456.69 91410619.78 109395389.9 11 11 11 Met-loss [N-Term] regulation of biological process;transport antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 100503605; 101488143; 15129 ENSMUSG00000073940.3; ENSMUSG00000052305.6 Beta-s; Hbb-bs; Hbb-bt; Hbb-b1 7 Erythrocytes take up carbon dioxide and release oxygen; Neutrophil degranulation; Factors involved in megakaryocyte development and platelet production; Erythrocytes take up oxygen and release carbon dioxide; Scavenging of heme from plasma African trypanosomiasis; Malaria 0 High Q99PV0 Pre-mRNA-processing-splicing factor 8 OS=Mus musculus OX=10090 GN=Prpf8 PE=1 SV=2 0 128.853 20 34 54 34 2335 273.4 8.84 28 20 28 26 3234089.313 41513772.19 37256944.13 6 25 21 cell organization and biogenesis;metabolic process;response to stimulus membrane;nucleus;spliceosomal complex catalytic activity;protein binding;RNA binding "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" 192159 ENSMUSG00000020850.14 Prpf8 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P50518 V-type proton ATPase subunit E 1 OS=Mus musculus OX=10090 GN=Atp6v1e1 PE=1 SV=2 0 71.814 46 13 53 13 226 26.1 8.43 7 10 11 8 20 25 18697759.06 85834949.77 123761478.3 10 12 13 Met-loss+Acetyl [N-Term] transport cytoplasm;cytosol;endosome;membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf01991 11973 ENSMUSG00000019210.10 Atp6v1e1 6 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High Q8R0Y6 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Mus musculus OX=10090 GN=Aldh1l1 PE=1 SV=1 0 102.806 42 30 53 30 902 98.6 5.91 13 20 16 14 22 17 16692201.58 49457484.13 58780774.03 25 27 25 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;protein binding "Pf00171, Pf00550, Pf00551, Pf02911" 107747 ENSMUSG00000030088.15 Aldh1l1 6 Metabolism of folate and pterines One carbon pool by folate 0 High Q9EQ20 "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Mus musculus OX=10090 GN=Aldh6a1 PE=1 SV=1" 0 79.658 45 18 53 18 535 57.9 8.07 7 15 13 9 19 25 23742924.99 74564235.94 115220641.4 14 18 18 cell differentiation;metabolic process mitochondrion catalytic activity;RNA binding Pf00171 104776 ENSMUSG00000021238.10 Aldh6a1 12 Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; beta-Alanine metabolism; Propanoate metabolism; Inositol phosphate metabolism; Carbon metabolism" 0 High Q8CG16 Complement C1r-A subcomponent OS=Mus musculus OX=10090 GN=C1ra PE=1 SV=1 0 69.011 37 18 52 18 707 80 5.66 15 11 10 24 13 15 37273995.92 35164698.75 40011838.38 16 14 13 defense response;metabolic process;regulation of biological process;response to stimulus catalytic activity;metal ion binding "Pf00084, Pf00089, Pf00431, Pf07645, Pf12662, Pf14670" 50909 ENSMUSG00000055172.10 C1ra 6 Regulation of Complement cascade; Classical antibody-mediated complement activation Staphylococcus aureus infection; Phagosome; Complement and coagulation cascades; Pertussis; Systemic lupus erythematosus 0 High P08113 Endoplasmin OS=Mus musculus OX=10090 GN=Hsp90b1 PE=1 SV=2 0 92.925 32 23 52 21 802 92.4 4.82 5 20 13 5 28 19 12371817.5 77246199.13 71271854.81 14 20 19 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 22027 ENSMUSG00000020048.13 Hsp90b1 10 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR Thyroid hormone synthesis; Pathways in cancer; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Prostate cancer 2 High Q8CI43 Myosin light chain 6B OS=Mus musculus OX=10090 GN=Myl6b PE=1 SV=1 0 25.95 25 4 51 3 207 22.7 5.53 1 4 2 14 20 17 339930.1875 3069146 4512802.25 1 2 2 cellular component movement catalytic activity;metal ion binding;motor activity;structural molecule activity "Pf13405, Pf13499" 216459 ENSMUSG00000039824.4 Myl6b 10 Smooth Muscle Contraction Oxytocin signaling pathway; Vascular smooth muscle contraction 0 High Q91VW3 SH3 domain-binding glutamic acid-rich-like protein 3 OS=Mus musculus OX=10090 GN=Sh3bgrl3 PE=1 SV=1 0 49.603 76 7 50 7 93 10.5 5.14 4 7 6 8 19 23 61703527.88 219522312 361723992.5 8 9 9 cellular homeostasis;metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity "Pf00462, Pf04908" 73723 ENSMUSG00000028843.8 Sh3bgrl3 4 0 High Q9JHU4 Cytoplasmic dynein 1 heavy chain 1 OS=Mus musculus OX=10090 GN=Dync1h1 PE=1 SV=2 0 115.197 10 33 50 33 4644 531.7 6.42 1 23 24 1 24 25 4699675.977 21753145.59 37318066.27 15 24 27 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;membrane catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00769, Pf03028, Pf03915, Pf04156, Pf07246, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13173, Pf13207, Pf13401" 13424 ENSMUSG00000018707.13 Dync1h1 12 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR); Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPI-independent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; RHO GTPases Activate Formins; MHC class II antigen presentation Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High E9PV24 Fibrinogen alpha chain OS=Mus musculus OX=10090 GN=Fga PE=1 SV=1 0 58.054 21 13 50 13 789 87.4 6.11 7 12 11 9 22 19 16046368.94 44602084.38 50499046.06 11 13 13 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endoplasmic reticulum;extracellular metal ion binding;protein binding;structural molecule activity "Pf00147, Pf08702, Pf12160" 14161 ENSMUSG00000028001.16 Fga 3 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); p130Cas linkage to MAPK signaling for integrins; Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of TLR by endogenous ligand; Common Pathway of Fibrin Clot Formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation Platelet activation; Complement and coagulation cascades 0 High Q9DB20 "ATP synthase subunit O, mitochondrial OS=Mus musculus OX=10090 GN=Atp5po PE=1 SV=1" 0 70.816 63 11 49 11 213 23.3 9.99 10 9 9 18 15 16 83182687.55 94447999.63 63520244.13 12 12 10 metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf00213 28080; 102641678 ENSMUSG00000022956.10 Atp5o; LOC100047429; LOC102641678 16; 3 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q8K2C7 Protein OS-9 OS=Mus musculus OX=10090 GN=Os9 PE=1 SV=2 0 109.149 43 22 49 22 672 76.1 4.84 19 14 31 18 1103992.922 109595963 80438926.75 3 21 19 metabolic process;response to stimulus;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 216440 ENSMUSG00000040462.13 Os9 10 Hedgehog ligand biogenesis; ABC-family proteins mediated transport; ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High P48962 ADP/ATP translocase 1 OS=Mus musculus OX=10090 GN=Slc25a4 PE=1 SV=4 0 37.416 40 11 49 4 298 32.9 9.72 8 10 9 13 19 17 2668447.938 6691689 5363580.438 4 4 4 cell organization and biogenesis;regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 11739 ENSMUSG00000031633.4 Slc25a4 8 Regulation of insulin secretion HTLV-I infection; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway 0 High P50544 "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadvl PE=1 SV=3" 0 92.609 38 21 48 21 656 70.8 8.75 8 14 14 8 19 21 8841103.656 32982117.69 52200949.95 16 19 19 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 11370 ENSMUSG00000018574.14 Acadvl 11 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Fatty acid metabolism; Metabolic pathways; Fatty acid degradation 0 High P14106 Complement C1q subcomponent subunit B OS=Mus musculus OX=10090 GN=C1qb PE=1 SV=2 0 40.312 27 6 48 6 253 26.7 8.15 6 5 5 17 16 15 79343642.81 77712702.13 86628854.88 8 8 8 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00229, Pf00386" 12260 ENSMUSG00000036905.8 C1qb 4 Regulation of Complement cascade; Classical antibody-mediated complement activation Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Prion diseases; Systemic lupus erythematosus 0 High P17563 Methanethiol oxidase OS=Mus musculus OX=10090 GN=Selenbp1 PE=1 SV=2 0 93.834 45 17 48 17 472 52.5 6.29 4 15 13 5 21 22 11635482.94 43825851.5 50808605.44 12 15 13 cell differentiation;transport cytoplasm;cytosol;membrane;nucleus "Pf05694, Pf10282" 20341 ENSMUSG00000068874.13 Selenbp1 3 0 High Q8K0E8 Fibrinogen beta chain OS=Mus musculus OX=10090 GN=Fgb PE=1 SV=1 0 80.44 41 15 47 15 481 54.7 7.08 8 10 11 13 17 17 15723147.98 37563847.81 55155502.31 12 12 14 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular protein binding;structural molecule activity "Pf00147, Pf01920, Pf08702" 110135 ENSMUSG00000033831.5 Fgb 3 p130Cas linkage to MAPK signaling for integrins; Integrin cell surface interactions; Regulation of TLR by endogenous ligand; Common Pathway of Fibrin Clot Formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation Platelet activation; Complement and coagulation cascades 0 High Q922D8 "C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus OX=10090 GN=Mthfd1 PE=1 SV=4" 0 79.435 30 17 47 17 935 101.1 7.14 4 15 13 4 20 23 6628731.891 29069463.38 50029368.19 13 16 16 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding "Pf00763, Pf01268, Pf02882" 108156 ENSMUSG00000021048.7 Mthfd1 12 Metabolism of folate and pterines Metabolic pathways; One carbon pool by folate 0 High A0A087WS56 Fibronectin OS=Mus musculus OX=10090 GN=Fn1 PE=1 SV=1 0 96.254 16 25 47 25 2266 249.4 5.82 6 20 12 7 25 15 7652097.797 32774112.72 34723688.25 12 20 18 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00039, Pf00040, Pf00041" 14268 ENSMUSG00000026193.15 Fn1 1 0 High Q8CC88 von Willebrand factor A domain-containing protein 8 OS=Mus musculus OX=10090 GN=Vwa8 PE=1 SV=2 0 114.346 21 29 47 29 1905 213.3 6.6 4 18 20 4 18 25 15193072.45 67220781.56 82662370.38 19 22 25 extracellular;mitochondrion catalytic activity;nucleotide binding "Pf00092, Pf07728, Pf13191, Pf13519, Pf13521" 219189 ENSMUSG00000058997.7 Vwa8 14 0 High Q9D826 Peroxisomal sarcosine oxidase OS=Mus musculus OX=10090 GN=Pipox PE=1 SV=1 0 57.832 45 14 46 14 390 43.8 7.55 4 10 12 6 18 22 6715242.203 32163652.31 59592027.06 9 11 11 metabolic process catalytic activity;protein binding "Pf00890, Pf01266, Pf13450" 19193 ENSMUSG00000017453.4 Pipox 11 Lysine catabolism "Metabolic pathways; Lysine degradation; Glycine, serine and threonine metabolism; Peroxisome" 0 High P49813 Tropomodulin-1 OS=Mus musculus OX=10090 GN=Tmod1 PE=1 SV=2 0 63.469 60 16 46 15 359 40.4 5.1 6 14 13 7 19 20 10500710.65 30382695.59 50302548 12 15 14 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus protein binding Pf03250 21916 ENSMUSG00000028328.13 Tmod1 4 Striated Muscle Contraction 0 High Q61584 Fragile X mental retardation syndrome-related protein 1 OS=Mus musculus OX=10090 GN=Fxr1 PE=1 SV=2 0 71.598 38 18 46 17 677 76.2 6.98 8 14 12 9 20 17 26224782.2 58671362.13 62929791.13 14 16 14 cell differentiation;development;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00013, Pf05641, Pf12235, Pf13014" 14359 ENSMUSG00000027680.15 Fxr1 3 RNA transport 1 High Q9DCY0 Glycine N-acyltransferase-like protein Keg1 OS=Mus musculus OX=10090 GN=Keg1 PE=1 SV=1 0 93.859 68 14 46 14 295 33.7 8.43 6 12 13 7 16 23 16870309.56 60191706.56 105298766.4 11 13 12 Acetyl [N-Term] cytoplasm;cytoskeleton;mitochondrion catalytic activity "Pf06021, Pf08444" 64697 ENSMUSG00000024694.9 Keg1 19 Phenylalanine metabolism 0 High Q9WV32 Actin-related protein 2/3 complex subunit 1B OS=Mus musculus OX=10090 GN=Arpc1b PE=1 SV=4 0 67.326 47 15 45 15 372 41 8.35 9 10 12 13 14 18 77796610.38 155337413.8 177106880.3 13 14 14 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton protein binding;structural molecule activity Pf00400 11867 ENSMUSG00000029622.16 Arpc1b 5 RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High Q8VD75 Huntingtin-interacting protein 1 OS=Mus musculus OX=10090 GN=Hip1 PE=1 SV=2 0 92.024 30 22 45 22 1029 115.1 5.43 8 14 16 8 18 19 12261920.31 32332070.13 45423491.69 19 21 22 cell death;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01417, Pf01576, Pf01608, Pf06705, Pf07651, Pf07888, Pf09730, Pf12128, Pf13851, Pf14362" 215114 ENSMUSG00000039959.13 Hip1 5 Clathrin-mediated endocytosis Huntington's disease 0 High Q3UZZ6 Sulfotransferase 1 family member D1 OS=Mus musculus OX=10090 GN=Sult1d1 PE=1 SV=1 0 88.528 66 14 45 14 295 35.1 5.76 3 10 11 3 21 21 6748857.742 32039770.48 47551543.88 11 15 17 metabolic process cytoplasm catalytic activity Pf00685 53315 ENSMUSG00000029273.10 Sult1d1 5 0 High Q9D8E6 60S ribosomal protein L4 OS=Mus musculus OX=10090 GN=Rpl4 PE=1 SV=3 0 62.828 37 15 44 15 419 47.1 11 6 12 13 8 16 20 11951435.98 45460531.41 52353720.16 11 13 13 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00573, Pf14374" 67891 ENSMUSG00000032399.8 Rpl4 9 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8VCM7 Fibrinogen gamma chain OS=Mus musculus OX=10090 GN=Fgg PE=1 SV=1 0 78.96 48 16 44 16 436 49.4 5.86 5 15 10 9 21 14 25064340.13 56441436.41 59697766.38 9 13 13 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;extracellular metal ion binding;protein binding;structural molecule activity "Pf00147, Pf08702" 99571 ENSMUSG00000033860.13 Fgg 3 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); p130Cas linkage to MAPK signaling for integrins; Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of TLR by endogenous ligand; Common Pathway of Fibrin Clot Formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation Staphylococcus aureus infection; Platelet activation; Complement and coagulation cascades 0 High P47911 60S ribosomal protein L6 OS=Mus musculus OX=10090 GN=Rpl6 PE=1 SV=3 0 48.722 43 14 44 14 296 33.5 10.7 7 11 11 11 16 17 17583605.47 45322354.31 62740136.13 12 14 12 cell organization and biogenesis;metabolic process cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf01159, Pf03868" 19988 ENSMUSG00000029614.13 Rpl6 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P01872 Immunoglobulin heavy constant mu OS=Mus musculus OX=10090 GN=Ighm PE=1 SV=2 0 62.106 36 16 44 16 454 49.9 7.01 14 9 12 19 10 15 46668363.13 55262529.25 86156529.75 16 15 14 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;extracellular;membrane protein binding;receptor activity;signal transducer activity "Pf07654, Pf07679" 16019 Ighm 12 0 High H7BX01 "Dynamin-like 120 kDa protein, mitochondrial OS=Mus musculus OX=10090 GN=Opa1 PE=1 SV=1" 0 114.881 29 22 44 22 978 113.2 7.33 2 14 18 2 19 23 4843584.672 36284399.75 78287382.06 10 19 20 cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00350, Pf01926" 74143 ENSMUSG00000038084.16 Opa1 16 0 High P59913 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Pcmtd1 PE=1 SV=1 0 54.573 37 14 44 14 357 40.7 5.66 12 10 9 18 14 12 29895083.63 40726850.94 37506983.67 12 11 12 metabolic process cytoplasm;membrane catalytic activity "Pf01135, Pf12847, Pf13847" 319263 ENSMUSG00000051285.17 Pcmtd1 1 0 High P11499 Heat shock protein HSP 90-beta OS=Mus musculus OX=10090 GN=Hsp90ab1 PE=1 SV=3 0 79.995 32 20 43 12 724 83.2 5.03 7 14 12 7 20 16 9307557.531 34873971.58 50507493.63 16 16 15 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 15516 ENSMUSG00000023944.14 Hsp90ab1 17 The role of GTSE1 in G2/M progression after G2 checkpoint; HSF1 activation; Attenuation phase; Neutrophil degranulation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of actin dynamics for phagocytic cup formation; Aryl hydrocarbon receptor signalling; Sema3A PAK dependent Axon repulsion Progesterone-mediated oocyte maturation; NOD-like receptor signaling pathway; Pathways in cancer; Antigen processing and presentation; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Prostate cancer 6 High A0A0R4J083 "Long-chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadl PE=1 SV=1" 0 81.307 41 16 43 16 430 47.9 8.15 12 11 12 16 14 13 30570827.67 45759658.56 74763815.38 15 15 16 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 11363 ENSMUSG00000026003.5 Acadl 1 Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA PPAR signaling pathway; Fatty acid metabolism; Metabolic pathways; Fatty acid degradation 0 High Q9DBE0 Cysteine sulfinic acid decarboxylase OS=Mus musculus OX=10090 GN=Csad PE=1 SV=1 0 84.451 58 21 42 21 493 55.1 6.61 16 13 23 19 26102.88086 66512638.25 70544886.09 1 18 16 metabolic process catalytic activity "Pf00266, Pf00282, Pf01212" 246277 ENSMUSG00000023044.1 Csad 15 Taurine and hypotaurine metabolism; Metabolic pathways 0 High Q8C2Q8 ATP synthase subunit gamma OS=Mus musculus OX=10090 GN=Atp5c1 PE=1 SV=1 0 57.407 42 10 42 10 274 30.2 8.84 8 9 8 12 16 14 25175876.81 45902452 69768975 9 9 9 metabolic process;transport membrane;mitochondrion catalytic activity;RNA binding;transporter activity Pf00231 11949 ENSMUSG00000025781.14 Atp5c1 2 0 High Q9QYC0 Alpha-adducin OS=Mus musculus OX=10090 GN=Add1 PE=1 SV=2 0 117.821 44 21 42 20 735 80.6 5.9 6 18 13 6 23 13 16457524.28 58595295.19 76776926.38 12 17 18 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus protein binding;RNA binding;structural molecule activity Pf00596 11518 ENSMUSG00000029106.14 Add1 5 Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events 1 High E0CYV0 Protein-L-isoaspartate O-methyltransferase OS=Mus musculus OX=10090 GN=Pcmt1 PE=1 SV=1 0 64.55 47 13 42 13 286 30.4 7.24 12 9 9 18 13 11 30798957.81 42856421.5 59296667.38 12 11 11 metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity "Pf01135, Pf01209, Pf05175, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847" 18537 ENSMUSG00000019795.17 Pcmt1 10 Protein repair 0 High Q64516 Glycerol kinase OS=Mus musculus OX=10090 GN=Gk PE=1 SV=2 0 60.402 37 17 41 17 559 61.2 5.87 17 13 22 19 1927327.859 45356124.38 66264408.88 5 16 16 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00370, Pf02782" 14933 ENSMUSG00000025059.16 Gyk; Gk X Triglyceride biosynthesis PPAR signaling pathway; Metabolic pathways; Glycerolipid metabolism 0 High Q9R112 "Sulfide:quinone oxidoreductase, mitochondrial OS=Mus musculus OX=10090 GN=Sqor PE=1 SV=3" 0 84.843 47 17 41 17 450 50.3 9.09 3 11 16 5 12 24 10909783.77 45502405 54893053.94 14 17 17 metabolic process membrane;mitochondrion catalytic activity "Pf07992, Pf13738" 59010 ENSMUSG00000005803.14 Sqrdl; Sqor 2 Sulfide oxidation to sulfate Sulfur metabolism 0 High P27659 60S ribosomal protein L3 OS=Mus musculus OX=10090 GN=Rpl3 PE=1 SV=3 0 52.182 37 12 41 12 403 46.1 10.21 8 12 8 10 19 12 9805178.258 31981865.78 39744949.44 9 11 11 cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytosol;nucleus;ribosome RNA binding;structural molecule activity Pf00297 27367 ENSMUSG00000060036.13 Rpl3 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q5JC28 Epidermal growth factor receptor pathway substrate 15 isoform B OS=Mus musculus OX=10090 GN=Eps15 PE=1 SV=1 0 89.665 32 17 41 17 793 86.6 4.65 5 14 14 5 18 18 14673322.16 32939579.5 37809068.97 14 13 14 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane metal ion binding;protein binding Pf12763 13858 ENSMUSG00000028552.13 Eps15 4 0 High Q3U3J1 2-oxoisovalerate dehydrogenase subunit alpha OS=Mus musculus OX=10090 GN=Bckdha PE=1 SV=1 0 73.344 44 14 40 14 446 50.7 8.06 8 11 13 10 14 16 13802620.81 24957331.88 30964497.25 14 13 14 metabolic process mitochondrion catalytic activity;metal ion binding;protein binding "Pf00456, Pf00676" 12039 ENSMUSG00000060376.7 Bckdha 7 Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism" 0 High Q9D1K2 V-type proton ATPase subunit F OS=Mus musculus OX=10090 GN=Atp6v1f PE=1 SV=2 0 57.33 84 10 40 10 119 13.4 5.82 4 9 9 5 18 17 6067728.547 28670320.13 28468263.78 9 9 9 transport membrane catalytic activity;transporter activity Pf01990 66144 ENSMUSG00000004285.12 Atp6v1f 6 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High Q91VN6 Probable ATP-dependent RNA helicase DDX41 OS=Mus musculus OX=10090 GN=Ddx41 PE=1 SV=2 0 55.717 31 17 40 17 622 69.8 6.7 14 7 8 20 9 11 15549964.78 13937268.97 19343290.73 15 14 12 cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf13307" 72935 ENSMUSG00000021494.8 Ddx41 13 STING mediated induction of host immune responses; Regulation of innate immune responses to cytosolic DNA 0 High F7BHJ0 Clathrin light chain (Fragment) OS=Mus musculus OX=10090 GN=Cltb PE=1 SV=1 0 22.471 49 8 40 1 123 14.2 8.75 5 7 7 8 18 14 810784.9375 918894.25 1 1 transport membrane structural molecule activity Pf01086 ENSMUSG00000047547.14 13 0 High Q02105 Complement C1q subcomponent subunit C OS=Mus musculus OX=10090 GN=C1qc PE=1 SV=2 0 42.618 30 6 40 6 246 26 8.54 5 6 4 14 14 12 65777167.44 75060987.56 99931955.25 8 8 7 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00229, Pf00386, Pf01391" 12262 ENSMUSG00000036896.5 C1qc 4 Regulation of Complement cascade; Classical antibody-mediated complement activation Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Prion diseases; Systemic lupus erythematosus 0 High A0A0G2JEP4 Leucine-rich repeat flightless-interacting protein 2 OS=Mus musculus OX=10090 GN=Lrrfip2 PE=1 SV=1 0 73.054 42 12 39 11 424 48.4 5.54 5 9 11 6 15 18 13328305.22 41548505.31 56376713.19 10 12 12 metabolic process;regulation of biological process;response to stimulus protein binding "Pf04111, Pf09738" 71268 ENSMUSG00000032497.16 Lrrfip2 9 1 High P08752 Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Mus musculus OX=10090 GN=Gnai2 PE=1 SV=5 0 81.101 49 13 39 9 355 40.5 5.45 4 11 12 4 14 21 22123849.63 51769389.69 76292656.31 10 11 12 cell division;cell proliferation;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503" 14678 ENSMUSG00000032562.13 Gnai2 9 "Adenylate cyclase inhibitory pathway; G-protein activation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Adrenaline,noradrenaline inhibits insulin secretion; PLC beta mediated events; ADP signalling through P2Y purinoceptor 12" Oxytocin signaling pathway; Leukocyte transendothelial migration; Morphine addiction; Cholinergic synapse; Chagas disease (American trypanosomiasis); Retrograde endocannabinoid signaling; Dopaminergic synapse; Progesterone-mediated oocyte maturation; GABAergic synapse; Regulation of lipolysis in adipocytes; Toxoplasmosis; Chemokine signaling pathway; Platelet activation; Melanogenesis; Axon guidance; Sphingolipid signaling pathway; Glutamatergic synapse; Pertussis; Parkinson's disease; Cocaine addiction; Long-term depression; cGMP-PKG signaling pathway; Rap1 signaling pathway; Pathways in cancer; Alcoholism; cAMP signaling pathway; Tight junction; Gastric acid secretion; Renin secretion; Gap junction; Circadian entrainment; Estrogen signaling pathway; Serotonergic synapse; Adrenergic signaling in cardiomyocytes 4 High P07356 Annexin A2 OS=Mus musculus OX=10090 GN=Anxa2 PE=1 SV=2 0 71.18 55 15 39 15 339 38.7 7.69 10 11 13 11 14 14 27689933.75 33739909.63 50757264.75 13 15 13 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endosome;extracellular;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding;RNA binding Pf00191 12306 ENSMUSG00000032231.14 Anxa2 9 Dissolution of Fibrin Clot; Neutrophil degranulation 0 High Q8CG14 Complement C1s-A subcomponent OS=Mus musculus OX=10090 GN=C1sa PE=2 SV=2 0 57.157 27 15 39 9 688 76.8 5.08 7 11 10 11 14 14 23573746.16 34391134 41162474.25 11 13 11 defense response;metabolic process;regulation of biological process;response to stimulus extracellular catalytic activity;metal ion binding;protein binding "Pf00084, Pf00089, Pf00431, Pf07645, Pf14670" 50908 C1s; C1s1 6 Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Systemic lupus erythematosus 5 High P62743 AP-2 complex subunit sigma OS=Mus musculus OX=10090 GN=Ap2s1 PE=1 SV=1 0 26.598 38 6 39 6 142 17 6.18 3 5 6 10 10 19 36776682.07 66514378.66 84039215.06 5 5 6 transport membrane protein binding;transporter activity Pf01217 232910 ENSMUSG00000008036.11 Ap2s1 7 "WNT5A-dependent internalization of FZD4; Trafficking of GluR2-containing AMPA receptors; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Huntington's disease; Synaptic vesicle cycle 0 High P51863 V-type proton ATPase subunit d 1 OS=Mus musculus OX=10090 GN=Atp6v0d1 PE=1 SV=2 0 48.309 33 11 39 11 351 40.3 5 7 11 8 10 16 13 20627971.7 66173565.25 47918961.94 9 11 11 cell organization and biogenesis;cellular homeostasis;response to stimulus;transport endosome;membrane catalytic activity;protein binding;transporter activity Pf01992 11972 ENSMUSG00000013160.7 Atp6v0d1 8 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Lysosome; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion; Viral carcinogenesis 0 High Q60737 Casein kinase II subunit alpha OS=Mus musculus OX=10090 GN=Csnk2a1 PE=1 SV=2 0 76.242 46 13 39 13 391 45.1 7.74 8 11 9 8 16 15 17321357.36 34442109.81 52398821.13 12 12 13 cell death;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf01633, Pf01636, Pf07714" 12995 ENSMUSG00000101523.1; ENSMUSG00000074698.10 Csnk2a1 2; 1 WNT mediated activation of DVL; Regulation of TP53 Activity through Phosphorylation; Synthesis of PC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Condensation of Prometaphase Chromosomes; Receptor Mediated Mitophagy; Regulation of PTEN stability and activity; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Herpes simplex infection; Wnt signaling pathway; Epstein-Barr virus infection; Adherens junction; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Tight junction; Measles 0 High P14148 60S ribosomal protein L7 OS=Mus musculus OX=10090 GN=Rpl7 PE=1 SV=2 0 52.768 47 15 39 15 270 31.4 10.89 7 12 10 8 15 16 13884780.09 53637842 58665476.75 13 15 14 Acetyl [N-Term] metabolic process cytoplasm;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf00327, Pf08079" 19989 ENSMUSG00000043716.13 Rpl7 1 Ribosome 0 High Q9Z1G3 V-type proton ATPase subunit C 1 OS=Mus musculus OX=10090 GN=Atp6v1c1 PE=1 SV=4 0 71.288 53 19 38 19 382 43.9 7.46 5 17 12 6 19 13 8999268.156 58805088.44 54605468.88 13 18 15 Met-loss+Acetyl [N-Term] transport cytoplasm;membrane catalytic activity;transporter activity Pf03223 66335 ENSMUSG00000022295.7 Atp6v1c1 15 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High O70325 Phospholipid hydroperoxide glutathione peroxidase OS=Mus musculus OX=10090 GN=Gpx4 PE=1 SV=4 0 39.608 50 11 38 11 197 22.2 8.46 4 9 8 7 16 15 15131824.44 54603678.81 68916324.81 10 11 10 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding Pf00255 625249 ENSMUSG00000075706.10 Gpx4 10 Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives Glutathione metabolism 0 High P25444 40S ribosomal protein S2 OS=Mus musculus OX=10090 GN=Rps2 PE=1 SV=3 0 44.658 43 12 38 12 293 31.2 10.24 6 10 10 6 15 17 15112211.63 39690688.88 45595853.25 12 12 11 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00333, Pf03719" 16898; 546298 ENSMUSG00000044533.15 Rps2; Rps2-ps13 17; X Ribosome 0 High Q8BFR5 "Elongation factor Tu, mitochondrial OS=Mus musculus OX=10090 GN=Tufm PE=1 SV=1" 0 83.888 40 15 38 15 452 49.5 7.56 5 12 15 5 16 17 19983190 55816908 70381715 14 15 15 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00009, Pf03143, Pf03144" 233870 ENSMUSG00000073838.10 Tufm 7 0 High P24270 Catalase OS=Mus musculus OX=10090 GN=Cat PE=1 SV=4 0 70.797 33 13 38 13 527 59.8 7.88 5 8 12 7 12 19 14848398.38 25247842.94 44987042 12 10 12 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion;vacuole antioxidant activity;catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00199, Pf06628" 12359 ENSMUSG00000027187.10 Cat 2 Neutrophil degranulation; Detoxification of Reactive Oxygen Species FoxO signaling pathway; Tryptophan metabolism; Amyotrophic lateral sclerosis (ALS); Longevity regulating pathway; Carbon metabolism; Glyoxylate and dicarboxylate metabolism; Longevity regulating pathway - multiple species; Peroxisome 0 High Q9CQR4 Acyl-coenzyme A thioesterase 13 OS=Mus musculus OX=10090 GN=Acot13 PE=1 SV=1 0 40.911 69 7 38 7 140 15.2 8.82 6 7 6 12 13 13 69764150.44 67068056.88 64626970.69 6 6 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus catalytic activity Pf03061 66834 ENSMUSG00000006717.6 Acot13 13 Mitochondrial Fatty Acid Beta-Oxidation 0 High Q8BMF4 "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dlat PE=1 SV=2" 0 53.481 24 11 38 11 642 67.9 8.57 9 8 7 16 14 8 43755774.56 33790199.13 35452129.19 10 10 10 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 235339 ENSMUSG00000000168.9 Dlat 9 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; Carbon metabolism 0 High Q8BGS1 Band 4.1-like protein 5 OS=Mus musculus OX=10090 GN=Epb41l5 PE=1 SV=1 0 76.29 30 14 37 14 731 81.6 6.39 11 8 8 14 9 14 45739745.06 52748409.41 52913849.94 13 14 13 cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 226352 ENSMUSG00000026383.14 Epb4.1l5; Epb41l5 1 Neurexins and neuroligins 0 High Q91VC3 Eukaryotic initiation factor 4A-III OS=Mus musculus OX=10090 GN=Eif4a3 PE=1 SV=3 0 76.953 51 17 37 16 411 46.8 6.73 1 15 13 1 20 16 3834388.848 49955358 62057978.47 14 16 16 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271" 192170 ENSMUSG00000025580.15 Eif4a3 11 mRNA 3'-end processing; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; mRNA Splicing - Major Pathway; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; Deadenylation of mRNA mRNA surveillance pathway; Spliceosome; RNA transport 1 High Q8CIE6 Coatomer subunit alpha OS=Mus musculus OX=10090 GN=Copa PE=1 SV=2 0 83.754 22 21 37 21 1224 138.3 7.65 1 16 15 1 18 18 5688169.242 23885666.75 43868146.19 15 18 20 regulation of biological process;transport cytoplasm;extracellular;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053, Pf06957" 12847 ENSMUSG00000026553.17 Copa 1 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High P14824 Annexin A6 OS=Mus musculus OX=10090 GN=Anxa6 PE=1 SV=3 0 72.731 41 21 36 21 673 75.8 5.5 3 10 16 3 14 19 9217863.219 32952257.81 46009604.34 17 19 20 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus metal ion binding;nucleotide binding;protein binding;transporter activity Pf00191 11749 ENSMUSG00000018340.13 Anxa6 11 0 High P97351 40S ribosomal protein S3a OS=Mus musculus OX=10090 GN=Rps3a PE=1 SV=3 0 45.256 55 16 35 16 264 29.9 9.73 9 11 8 11 14 10 11753696.56 36172163.97 47716456.06 13 14 14 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01015 20091 ENSMUSG00000028081.6 Rps3a; Rps3a1 3 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q02248 Catenin beta-1 OS=Mus musculus OX=10090 GN=Ctnnb1 PE=1 SV=1 0 74.568 34 18 35 15 781 85.4 5.86 10 7 11 11 8 16 20687906.56 21100827.55 38808204.38 16 17 15 cell communication;cell differentiation;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;protein binding;signal transducer activity Pf00514 12387 ENSMUSG00000006932.17 Ctnnb1 9 Beta-catenin phosphorylation cascade; Deactivation of the beta-catenin transactivating complex; VEGFR2 mediated vascular permeability; Ca2+ pathway; Adherens junctions interactions; Formation of the beta-catenin:TCF transactivating complex; RHO GTPases activate IQGAPs; Disassembly of the destruction complex and recruitment of AXIN to the membrane; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Apoptotic cleavage of cell adhesion proteins; CDO in myogenesis; RUNX3 regulates WNT signaling Leukocyte transendothelial migration; Wnt signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Endometrial cancer; Basal cell carcinoma; Hippo signaling pathway; Breast cancer; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; HTLV-I infection; Adherens junction; Proteoglycans in cancer; Thyroid hormone signaling pathway; Rap1 signaling pathway; Pathways in cancer; Thyroid cancer; Tight junction; Colorectal cancer; Prostate cancer; Bacterial invasion of epithelial cells 3 High P48758 Carbonyl reductase [NADPH] 1 OS=Mus musculus OX=10090 GN=Cbr1 PE=1 SV=3 0 57.32 55 13 35 12 277 30.6 8.31 4 10 11 5 15 15 12099734.45 27675208.64 41659583.75 11 11 11 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;membrane;nucleus catalytic activity "Pf00106, Pf01370, Pf08659, Pf13561" 12408 ENSMUSG00000051483.8 Cbr1 16 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Metabolic pathways; Arachidonic acid metabolism; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 1 High P01837 Immunoglobulin kappa constant OS=Mus musculus OX=10090 GN=Igkc PE=1 SV=2 0 44.217 81 6 35 6 107 11.9 5.9 6 5 6 14 8 13 106941587.3 85292598.22 135578997.9 6 6 6 0 High P35486 "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha1 PE=1 SV=1" 0 63.195 39 13 35 13 390 43.2 8.19 10 6 8 13 9 13 19343619.31 16923300.94 19859650.16 13 10 9 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity Pf00676 18597 ENSMUSG00000031299.10 Pdha1 X Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 0 High P01029 Complement C4-B OS=Mus musculus OX=10090 GN=C4b PE=1 SV=3 0 69.188 16 17 34 17 1738 192.8 7.53 13 7 8 13 9 12 61826143.25 268493765.5 305968275.1 16 11 12 defense response;metabolic process;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 12268 ENSMUSG00000073418.4 C4b 17 Regulation of Complement cascade; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Activation of C3 and C5; Post-translational protein phosphorylation; Initial triggering of complement Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Systemic lupus erythematosus 0 High Q8CAQ8 MICOS complex subunit Mic60 OS=Mus musculus OX=10090 GN=Immt PE=1 SV=1 0 78.13 29 19 34 19 757 83.8 6.61 4 9 11 4 13 17 9889753.836 27390584.88 65166231.94 14 18 18 cell organization and biogenesis;cellular homeostasis membrane;mitochondrion protein binding;RNA binding Pf09731 76614 ENSMUSG00000052337.15 Immt 6 0 High Q9Z1R9 "Protease, serine 1 (trypsin 1) OS=Mus musculus OX=10090 GN=Prss1 PE=1 SV=1" 0 23.708 16 2 34 2 246 26.1 4.94 1 1 2 9 11 14 222743863 240126224 329931973.8 3 2 3 metabolic process catalytic activity Pf00089 114228 ENSMUSG00000062751.5 Prss1 6 "Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation; Collagen degradation; Antimicrobial peptides; Activation of Matrix Metalloproteinases" 0 High Q9QYB5 Gamma-adducin OS=Mus musculus OX=10090 GN=Add3 PE=1 SV=2 0 57.829 22 14 34 14 706 78.7 5.95 5 10 11 5 14 15 8174729.57 33508282.13 44789622.63 12 14 12 response to stimulus chromosome;cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity Pf00596 27360 ENSMUSG00000025026.14 Add3 19 Miscellaneous transport and binding events 0 High E9Q906 Catenin delta-1 OS=Mus musculus OX=10090 GN=Ctnnd1 PE=1 SV=1 0 69.236 24 13 34 13 839 93.4 6.3 5 8 10 5 11 18 8239966.023 15883771.88 32820952.19 10 12 12 protein binding Pf00514 ENSMUSG00000034101.14 2 0 High A2A841 Protein 4.1 OS=Mus musculus OX=10090 GN=Epb41 PE=1 SV=1 0 48.502 21 16 33 15 869 97.2 5.49 10 9 8 12 11 10 14902921.97 34395689.63 44796392.13 15 15 15 cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" 269587 ENSMUSG00000028906.16 Epb4.1; Epb41 4 1 High P62880 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Mus musculus OX=10090 GN=Gnb2 PE=1 SV=3 0 68.502 51 13 33 7 340 37.3 6 4 12 10 5 13 15 18223790.88 35027027.59 64454588.13 9 12 11 Met-loss+Acetyl [N-Term] regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;protein binding;signal transducer activity Pf00400 14693 ENSMUSG00000029713.15 Gnb2 5 "Glucagon signaling in metabolic regulation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Adrenaline,noradrenaline inhibits insulin secretion; Activation of G protein gated Potassium channels; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon-type ligand receptors; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" Morphine addiction; Cholinergic synapse; Retrograde endocannabinoid signaling; Dopaminergic synapse; Ras signaling pathway; GABAergic synapse; Chemokine signaling pathway; Glutamatergic synapse; Pathways in cancer; Alcoholism; PI3K-Akt signaling pathway; Circadian entrainment; Serotonergic synapse 5 High P62869 Elongin-B OS=Mus musculus OX=10090 GN=Elob PE=1 SV=1 0 29.04 67 9 33 9 118 13.2 5.01 7 6 8 11 11 11 31967957 46479167.94 41126098.75 9 9 8 Acetyl [N-Term] metabolic process;regulation of biological process nucleus protein binding Pf00240 67673 ENSMUSG00000055839.5 Tceb2; Elob 17 RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin mediated proteolysis; HIF-1 signaling pathway; Pathways in cancer; Renal cell carcinoma 0 High P12970 60S ribosomal protein L7a OS=Mus musculus OX=10090 GN=Rpl7a PE=1 SV=2 0 49.802 40 13 32 13 266 30 10.56 8 9 10 8 10 14 15095043.28 40144485.69 64583804.25 11 11 12 metabolic process cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding Pf01248 27176 ENSMUSG00000062647.16 Rpl7a 2 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9EP89 "Serine beta-lactamase-like protein LACTB, mitochondrial OS=Mus musculus OX=10090 GN=Lactb PE=1 SV=1" 0 47.632 33 14 32 14 551 60.7 8.9 13 7 4 18 9 5 16129357.44 10228821.45 9641796.156 13 10 6 metabolic process;regulation of biological process cytosol;membrane;mitochondrion catalytic activity;protein binding Pf00144 80907 ENSMUSG00000032370.8 Lactb 9 0 High A2A513 "Keratin, type I cytoskeletal 10 OS=Mus musculus OX=10090 GN=Krt10 PE=1 SV=1" 0 31.508 11 7 32 3 561 57 5.07 7 4 5 16 8 8 60622473.75 26918215 56342635.63 6 6 7 cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity Pf00038 16661 ENSMUSG00000019761.10 Krt10 11 Formation of the cornified envelope Staphylococcus aureus infection 4 High Q3UH68 LIM and calponin homology domains-containing protein 1 OS=Mus musculus OX=10090 GN=Limch1 PE=1 SV=2 0 64.828 21 14 32 14 1057 118.1 5.48 3 13 9 3 18 11 4428244.156 23022513.13 18356916.47 8 14 12 Met-loss+Acetyl [N-Term] cell organization and biogenesis metal ion binding;protein binding "Pf00307, Pf00412" 77569 ENSMUSG00000037736.18 Limch1 5 0 High Q91Y97 Fructose-bisphosphate aldolase B OS=Mus musculus OX=10090 GN=Aldob PE=1 SV=3 0 46.155 44 15 32 15 364 39.5 8.27 6 12 9 8 14 10 15390305.09 35797959.25 42696639.16 13 15 12 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus;vacuole catalytic activity;protein binding Pf00274 230163 ENSMUSG00000028307.9 Aldob 4 Fructose catabolism; Gluconeogenesis; Glycolysis Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Carbon metabolism; Fructose and mannose metabolism 0 High P62908 40S ribosomal protein S3 OS=Mus musculus OX=10090 GN=Rps3 PE=1 SV=1 0 35.638 51 11 31 11 243 26.7 9.66 5 8 9 5 13 13 8058321.031 32393060.34 43853622.75 8 11 10 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity "Pf00189, Pf07650" 27050 ENSMUSG00000030744.13 Rps3 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P70404 "Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial OS=Mus musculus OX=10090 GN=Idh3g PE=1 SV=1" 0 61.324 44 12 31 12 393 42.8 9.01 5 7 11 6 8 17 8446706.031 21059938.13 36673630.63 8 9 10 metabolic process;regulation of biological process mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00180 15929 ENSMUSG00000002010.17 Idh3g X Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism 0 High H7BX95 Serine/arginine-rich-splicing factor 1 OS=Mus musculus OX=10090 GN=Srsf1 PE=1 SV=1 0 34.086 41 10 31 10 253 28.3 10.08 2 10 7 3 15 13 4041166.75 53585402.75 60094255.31 6 9 8 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000018379.17; ENSMUSG00000098301.6 11; CHR_MG3829_PATCH 0 High Q8K2B3 "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Mus musculus OX=10090 GN=Sdha PE=1 SV=1" 0 59.48 35 16 31 16 664 72.5 7.37 8 10 10 8 11 12 14854570.97 34453461.38 39135640.13 13 15 14 metabolic process;transport membrane;mitochondrion catalytic activity;nucleotide binding "Pf00890, Pf02910" 66945 ENSMUSG00000021577.13 Sdha 13 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Carbon metabolism 0 High Q62093 Serine/arginine-rich splicing factor 2 OS=Mus musculus OX=10090 GN=Srsf2 PE=1 SV=4 0 27.222 23 5 31 5 221 25.5 11.85 3 5 4 3 15 13 4803971.109 39894101.75 45196054 5 5 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 20382 ENSMUSG00000034120.18 Srsf2 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High Q9Z1E4 "Glycogen [starch] synthase, muscle OS=Mus musculus OX=10090 GN=Gys1 PE=1 SV=2" 0 56.633 29 14 31 14 738 83.9 6.11 7 7 10 9 10 12 10519893.72 18714955 32749135.56 10 11 13 metabolic process cytoplasm;membrane catalytic activity;protein binding "Pf00534, Pf05693, Pf13579" 14936 ENSMUSG00000003865.16 Gys1 7 Glycogen synthesis Insulin signaling pathway; Metabolic pathways; Insulin resistance; Starch and sucrose metabolism; PI3K-Akt signaling pathway; AMPK signaling pathway; Glucagon signaling pathway 0 High P16331 Phenylalanine-4-hydroxylase OS=Mus musculus OX=10090 GN=Pah PE=1 SV=4 0 63.225 45 14 30 14 453 51.9 6.3 1 12 8 1 18 11 7638128.953 40193588.69 57875097.88 7 13 13 Met-loss+Acetyl [N-Term] metabolic process catalytic activity;metal ion binding;protein binding "Pf00351, Pf01842" 18478 ENSMUSG00000020051.17 Pah 10 Phenylalanine and tyrosine catabolism "Metabolic pathways; Phenylalanine, tyrosine and tryptophan biosynthesis; Biosynthesis of amino acids; Phenylalanine metabolism" 0 High P62702 "40S ribosomal protein S4, X isoform OS=Mus musculus OX=10090 GN=Rps4x PE=1 SV=2" 0 44.764 44 12 30 12 263 29.6 10.15 6 10 6 6 14 10 10065992.78 29707900.84 37098909.38 10 12 11 development;metabolic process;regulation of biological process cytoplasm;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00900, Pf08071" 20102 ENSMUSG00000031320.9 Rps4x X "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9CPW4 Actin-related protein 2/3 complex subunit 5 OS=Mus musculus OX=10090 GN=Arpc5 PE=1 SV=3 0 37.545 62 6 30 6 151 16.3 5.67 5 6 5 8 13 9 23228311.78 39853961.5 46265138.38 7 7 7 cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton;endosome protein binding;structural molecule activity Pf04699 67771 ENSMUSG00000008475.13 Arpc5 1 RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High P19157 Glutathione S-transferase P 1 OS=Mus musculus OX=10090 GN=Gstp1 PE=1 SV=2 0 58.467 65 10 30 10 210 23.6 7.87 5 9 4 9 14 7 20233461.7 35258362.33 33432774.47 10 9 10 Met-loss [N-Term] cell communication;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus antioxidant activity;catalytic activity;enzyme regulator activity;protein binding "Pf00043, Pf02798" 14870 ENSMUSG00000060803.5; ENSMUSG00000097830.3 Gstp1 19; CHR_MG153_PATCH Glutathione conjugation; Neutrophil degranulation; Detoxification of Reactive Oxygen Species Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450; Prostate cancer 0 High P56391 Cytochrome c oxidase subunit 6B1 OS=Mus musculus OX=10090 GN=Cox6b1 PE=1 SV=2 0 23.258 71 7 30 7 86 10.1 8.72 6 7 3 9 17 4 66164187.56 204783537.3 214695728.4 5 6 5 membrane;mitochondrion catalytic activity;transporter activity Pf02297 110323 ENSMUSG00000036751.7 Cox6b1 7 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P31001 Desmin OS=Mus musculus OX=10090 GN=Des PE=1 SV=3 0 48.906 31 14 29 10 469 53.5 5.27 7 9 9 8 10 11 5041255.391 15246039.81 14903630.28 9 10 6 cell organization and biogenesis cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf03962, Pf04732" 13346 ENSMUSG00000026208.9 Des 1 Striated Muscle Contraction Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy 0 High Q7TT50 Serine/threonine-protein kinase MRCK beta OS=Mus musculus OX=10090 GN=Cdc42bpb PE=1 SV=2 0 61.576 14 20 29 20 1713 194.6 6.46 3 14 10 3 15 11 6482116.844 22493345.34 25067929.47 12 15 15 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding "Pf00069, Pf00130, Pf00261, Pf00433, Pf00769, Pf00780, Pf00786, Pf01576, Pf02463, Pf03148, Pf03962, Pf04111, Pf04156, Pf04849, Pf05276, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf06008, Pf06160, Pf07111, Pf07321, Pf07714, Pf07888, Pf07926, Pf08317, Pf08826, Pf09726, Pf09728, Pf09730, Pf09731, Pf09787, Pf10174, Pf10473, Pf10498, Pf12072, Pf12128, Pf12718, Pf12795, Pf13514, Pf13851, Pf13868, Pf13870, Pf14817, Pf14988, Pf14992, Pf15035, Pf15294, Pf15558, Pf15619" 217866 ENSMUSG00000021279.4 Cdc42bpb 12 0 High Q91ZA3 "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Mus musculus OX=10090 GN=Pcca PE=1 SV=2" 0 73.681 38 20 29 20 724 79.9 7.25 18 8 19 10 2577422.828 22916856.81 20724081.47 9 16 15 extracellular;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf01071, Pf02222, Pf02258, Pf02785, Pf02786, Pf07478, Pf08442, Pf13533, Pf13535, Pf13549, Pf15632" 110821 ENSMUSG00000041650.15 Pcca 14 Propionyl-CoA catabolism; Biotin transport and metabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High P99027 60S acidic ribosomal protein P2 OS=Mus musculus OX=10090 GN=Rplp2 PE=1 SV=3 0 35.352 81 6 29 6 115 11.6 4.54 4 4 6 8 10 11 9611220.375 27946064.11 42315950.75 5 5 6 metabolic process membrane;ribosome structural molecule activity Pf00428 67186 ENSMUSG00000025508.13 Rplp2 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P57746 V-type proton ATPase subunit D OS=Mus musculus OX=10090 GN=Atp6v1d PE=1 SV=1 0 50.048 53 10 29 10 247 28.4 9.45 2 9 9 2 13 14 5761769.242 38230677.88 57622177.31 7 7 9 cell organization and biogenesis;transport membrane catalytic activity;transporter activity Pf01813 73834 ENSMUSG00000021114.9 Atp6v1d 12 "Ion channel transport; ROS, RNS production in phagocytes; Neutrophil degranulation; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High Q6ZWN5 40S ribosomal protein S9 OS=Mus musculus OX=10090 GN=Rps9 PE=1 SV=3 0 26.953 40 10 29 10 194 22.6 10.65 7 8 7 9 11 9 14116801.13 42220963.81 56892874.63 10 10 10 metabolic process;regulation of biological process cytoplasm;membrane;nucleus;ribosome RNA binding;structural molecule activity;translation regulator activity "Pf00163, Pf01479" 76846 ENSMUSG00000006333.14 Rps9 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High E9Q1F5 Myosin VC OS=Mus musculus OX=10090 GN=Myo5c PE=1 SV=1 0 40.941 7 10 29 4 1742 202.6 7.59 4 9 7 7 14 8 317157.0742 1826598.453 1758655.766 2 3 3 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00063, Pf00612, Pf00769, Pf01540, Pf01576, Pf01843, Pf02463, Pf02841, Pf03938, Pf03999, Pf04012, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf05667, Pf06008, Pf06160, Pf07111, Pf07888, Pf07926, Pf09726, Pf09728, Pf09730, Pf09731, Pf10168, Pf10174, Pf10211, Pf10473, Pf11932, Pf12128, Pf12137, Pf12709, Pf13166, Pf13514, Pf13851, Pf13863, Pf14662, Pf14915, Pf15112, Pf15450, Pf15558" 208943 ENSMUSG00000033590.8 Myo5c 9 0 High P26041 Moesin OS=Mus musculus OX=10090 GN=Msn PE=1 SV=3 0 43.483 24 15 29 9 577 67.7 6.6 7 8 8 8 11 10 31327368.03 136211251.7 84769863.63 15 13 10 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding "Pf00373, Pf00769, Pf09379, Pf09380" 17698 ENSMUSG00000031207.16 Msn X Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Proteoglycans in cancer; Measles 6 High Q3ULD5 "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Mus musculus OX=10090 GN=Mccc2 PE=1 SV=1" 0 52.201 31 12 29 12 563 61.3 8 8 9 10 8 10 11 10683414.31 15261400.59 16399647.5 12 12 9 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf01039, Pf03255" 78038 ENSMUSG00000021646.8 Mccc2 13 Biotin transport and metabolism; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways" 0 High P12787 "Cytochrome c oxidase subunit 5A, mitochondrial OS=Mus musculus OX=10090 GN=Cox5a PE=1 SV=2" 0 45.177 60 8 29 8 146 16.1 6.54 6 7 5 9 13 7 34776818 100826323.5 64433524.38 7 8 9 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;transporter activity Pf02284 12858 ENSMUSG00000000088.7 Cox5a 9 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P11881 "Inositol 1,4,5-trisphosphate receptor type 1 OS=Mus musculus OX=10090 GN=Itpr1 PE=1 SV=2" 0 69.817 11 20 29 19 2749 313 6.04 2 13 13 2 13 14 124044342 59089527 64260361.72 11 14 14 cell death;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" 16438 ENSMUSG00000030102.11 Itpr1 6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Effects of PIP2 hydrolysis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Gastrin-CREB signalling pathway via PKC and MAPK; cGMP effects; Elevation of cytosolic Ca2+ levels Oxytocin signaling pathway; Cholinergic synapse; Retrograde endocannabinoid signaling; Pancreatic secretion; Dopaminergic synapse; NOD-like receptor signaling pathway; Long-term potentiation; Platelet activation; Thyroid hormone synthesis; Oocyte meiosis; Huntington's disease; Glutamatergic synapse; Proteoglycans in cancer; Long-term depression; cGMP-PKG signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Gastric acid secretion; Renin secretion; Gap junction; Circadian entrainment; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Serotonergic synapse; Inflammatory mediator regulation of TRP channels; Apoptosis 1 High Q8BH95 "Enoyl-CoA hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Echs1 PE=1 SV=1" 0 49.481 45 9 29 9 290 31.5 8.48 4 6 9 4 10 15 7903650.203 33460335.13 56026182.13 7 8 9 metabolic process mitochondrion;organelle lumen catalytic activity Pf00378 93747 ENSMUSG00000025465.13 Echs1 7 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; beta-Alanine metabolism; Propanoate metabolism; Fatty acid elongation; Carbon metabolism" 0 High P99029 "Peroxiredoxin-5, mitochondrial OS=Mus musculus OX=10090 GN=Prdx5 PE=1 SV=2" 0 44.467 52 9 29 9 210 21.9 8.85 5 5 9 5 9 15 10807752.16 35010000.25 47381688.63 9 9 10 cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;DNA binding;enzyme regulator activity;protein binding "Pf00578, Pf08534" 54683 ENSMUSG00000024953.16 Prdx5 19 Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes Peroxisome 0 High Q6DFZ1 Golgi-specific brefeldin A-resistance factor 1 OS=Mus musculus OX=10090 GN=Gbf1 PE=1 SV=1 0 67.757 14 17 28 17 1861 206.7 5.8 13 12 14 14 20774.58203 17217795.53 21101642.59 1 15 13 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;Golgi;membrane;mitochondrion;organelle lumen protein binding "Pf01369, Pf12783" 107338 ENSMUSG00000025224.14 Gbf1 19 Clathrin derived vesicle budding; VxPx cargo-targeting to cilium; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic Endocytosis 0 High A2AQ51 Solute carrier family 12 member 1 OS=Mus musculus OX=10090 GN=Slc12a1 PE=1 SV=1 0 44.461 13 11 28 11 1090 119.7 7.74 4 8 9 4 11 13 6119988.891 14114741.13 28331182.34 7 8 10 regulation of biological process;response to stimulus;transport cell surface;membrane protein binding;transporter activity "Pf00324, Pf08403, Pf13520" 20495 ENSMUSG00000027202.12 Slc12a1 2 Cation-coupled Chloride cotransporters 0 High P19783 "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Mus musculus OX=10090 GN=Cox4i1 PE=1 SV=2" 0 27.471 36 7 28 7 169 19.5 9.23 5 7 6 8 12 8 19881979.75 45919935.75 25382587.75 7 7 7 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus catalytic activity;transporter activity Pf02936 12857 ENSMUSG00000031818.12 Cox4i1 8 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q9R0L6 Pericentriolar material 1 protein OS=Mus musculus OX=10090 GN=Pcm1 PE=1 SV=2 0 68.935 12 17 28 17 2025 228.7 5.01 2 13 10 2 16 10 7454860.551 23399931 23035411.69 9 14 13 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding 18536 ENSMUSG00000031592.10 Pcm1 8 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes 0 High Q9R0H0 Peroxisomal acyl-coenzyme A oxidase 1 OS=Mus musculus OX=10090 GN=Acox1 PE=1 SV=5 0 82.431 33 15 28 15 661 74.6 8.48 1 6 14 1 9 18 1805838.375 14935584.38 29040238.81 5 10 12 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf01756, Pf02770, Pf14749" 11430 ENSMUSG00000020777.16 Acox1 11 Beta-oxidation of very long chain fatty acids; alpha-linolenic acid (ALA) metabolism PPAR signaling pathway; Fatty acid metabolism; Metabolic pathways; Fatty acid degradation; alpha-Linolenic acid metabolism; cAMP signaling pathway; Biosynthesis of unsaturated fatty acids; Peroxisome 0 High E9Q6R7 Utrophin OS=Mus musculus OX=10090 GN=Utrn PE=1 SV=1 0 71.456 7 18 27 18 3430 392.5 5.33 2 11 13 2 12 13 2369474.609 15256824.84 16955646.81 7 14 14 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane metal ion binding;protein binding "Pf00307, Pf00397, Pf00435, Pf00569, Pf09068, Pf09069, Pf11971" 22288 ENSMUSG00000019820.10 Utrn 10 0 High Q91X17 Uromodulin OS=Mus musculus OX=10090 GN=Umod PE=1 SV=1 0 29.326 20 10 27 10 642 70.8 4.88 4 6 9 6 10 11 11818123.44 23668162.19 34345410.19 8 8 9 cellular component movement;regulation of biological process cell surface;extracellular;Golgi;membrane metal ion binding;protein binding "Pf00008, Pf00100, Pf06247, Pf07645, Pf12662, Pf12947" 22242 ENSMUSG00000030963.6 Umod 7 Asparagine N-linked glycosylation 0 High Q3UNZ8 Quinone oxidoreductase-like protein 2 OS=Mus musculus OX=10090 GN=Cryzl2 PE=1 SV=1 0 76.155 61 12 27 12 350 37.8 8.9 2 7 12 2 12 13 4155228.594 28909397.88 32243183.69 5 7 7 metabolic process mitochondrion catalytic activity "Pf00107, Pf08240, Pf13602" 226527 ENSMUSG00000033488.11 BC026585; Cryzl2 1 0 High F8VQB6 Unconventional myosin-X OS=Mus musculus OX=10090 GN=Myo10 PE=1 SV=1 0 61.969 10 16 27 14 2062 237.2 6.25 2 11 12 2 11 14 16350687.67 33008624.59 64369576.5 8 13 13 cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00169, Pf00373, Pf00769, Pf00784, Pf00887, Pf12325, Pf15409" 17909 ENSMUSG00000022272.17 Myo10 15 Regulation of actin dynamics for phagocytic cup formation Fc gamma R-mediated phagocytosis 1 High P08730 "Keratin, type I cytoskeletal 13 OS=Mus musculus OX=10090 GN=Krt13 PE=1 SV=2" 0 24.044 11 7 27 1 437 47.7 4.86 6 4 4 13 7 7 177165.3281 750923.1875 1011778 1 1 1 cell organization and biogenesis;response to stimulus cytoskeleton;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 16663 ENSMUSG00000044041.4 Krt13 11 Formation of the cornified envelope 0 High Q9Z2I9 "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Sucla2 PE=1 SV=2" 0 63.947 37 15 27 15 463 50.1 7.01 3 13 9 3 15 9 6364672.07 29024972.81 36259897.5 9 14 12 metabolic process mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf00549, Pf02222, Pf02786, Pf08442, Pf13535, Pf13549" 20916 ENSMUSG00000022110.13 Sucla2 14 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Propanoate metabolism; Carbon metabolism 0 High Q01853 Transitional endoplasmic reticulum ATPase OS=Mus musculus OX=10090 GN=Vcp PE=1 SV=4 0 72.22 27 15 27 15 806 89.3 5.26 7 7 10 7 8 12 5692806.531 13024840.38 12512274.81 9 11 10 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;proteasome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401" 269523 ENSMUSG00000028452.7 Vcp 4 N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Protein methylation; Translesion Synthesis by POLH; HSF1 activation; Ovarian tumor domain proteases; Hedgehog ligand biogenesis; ABC-family proteins mediated transport; Neutrophil degranulation Legionellosis; Protein processing in endoplasmic reticulum 0 High Q80V42 Carboxypeptidase M OS=Mus musculus OX=10090 GN=Cpm PE=1 SV=2 0 44.121 37 12 27 12 443 50.5 7.78 5 9 8 6 10 11 7112540.688 15258067.41 21498813.66 8 10 10 metabolic process cell surface;membrane catalytic activity;metal ion binding "Pf00246, Pf04952, Pf13620, Pf13715" 70574 ENSMUSG00000020183.11 Cpm 10 Post-translational modification: synthesis of GPI-anchored proteins 0 High A0A0A0MQ68 "Glutaryl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Gcdh PE=1 SV=1" 0 53.158 35 10 27 10 447 49.5 8.72 4 8 8 5 10 12 9518175.438 25352335.64 36577502.06 7 10 10 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 270076 ENSMUSG00000003809.14 Gcdh 8 Tryptophan metabolism; Metabolic pathways; Lysine degradation; Fatty acid degradation 0 High Q9WVK4 EH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Ehd1 PE=1 SV=1 0 46.319 26 13 27 8 534 60.6 6.83 2 9 11 2 9 16 3919757.297 14709180.66 21931084.25 10 12 12 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endosome;membrane metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 13660 ENSMUSG00000024772.9; ENSMUSG00000107039.1 Ehd1 19; CHR_MG4249_PATCH Factors involved in megakaryocyte development and platelet production Endocytosis 5 High P97449 Aminopeptidase N OS=Mus musculus OX=10090 GN=Anpep PE=1 SV=4 0 79.611 19 14 27 14 966 109.6 5.9 3 9 11 3 9 15 6480076.594 15436869.75 20603724.63 8 9 9 cell communication;cell differentiation;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;organelle lumen catalytic activity;metal ion binding "Pf01433, Pf11838, Pf13485" 16790 ENSMUSG00000039062.15 Anpep 7 Neutrophil degranulation Glutathione metabolism; Metabolic pathways; Renin-angiotensin system; Hematopoietic cell lineage 0 High Q99MN9 "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Mus musculus OX=10090 GN=Pccb PE=1 SV=2" 0 74.973 51 17 27 17 541 58.4 7.66 10 14 12 15 2236103.695 20438836.44 18676959.63 8 11 13 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding Pf01039 66904 ENSMUSG00000032527.13 Pccb 9 Propionyl-CoA catabolism; Biotin transport and metabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High P26040 Ezrin OS=Mus musculus OX=10090 GN=Ezr PE=1 SV=3 0 43.929 25 13 27 8 586 69.4 6.1 7 7 5 9 10 8 6635934.969 16595847.91 22428761.25 7 8 5 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane protein binding;RNA binding "Pf00373, Pf00769, Pf09379, Pf09380" 22350 ENSMUSG00000052397.8 Ezr 17 Recycling pathway of L1; Netrin-1 signaling Leukocyte transendothelial migration; Regulation of actin cytoskeleton; MicroRNAs in cancer; Proteoglycans in cancer; Gastric acid secretion 0 High A2AS45 Plakophilin-4 OS=Mus musculus OX=10090 GN=Pkp4 PE=1 SV=1 0 44.44 14 12 26 12 1163 128.4 8.91 7 9 8 7 9 10 10464450.5 12585681.06 17609719.63 8 7 7 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding "Pf00514, Pf13646" 227937 ENSMUSG00000026991.20 Pkp4 2 0 High Q8CG29 Myosin-1F-like protein OS=Mus musculus OX=10090 GN=Myo1f PE=1 SV=1 0 49.393 15 12 26 5 1098 125.1 9.17 2 10 8 3 11 12 574909.3711 2197023.5 2958739.656 4 4 3 defense response;regulation of biological process;response to stimulus;transport cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00018, Pf00063, Pf06017, Pf07653, Pf14604" 17916 ENSMUSG00000024300.16 Myo1f 17 0 High Q9CR51 V-type proton ATPase subunit G 1 OS=Mus musculus OX=10090 GN=Atp6v1g1 PE=1 SV=3 0 42.424 72 6 26 6 118 13.7 7.97 5 5 5 6 11 9 10975925.81 52745887.75 55595853 5 6 6 Met-loss+Acetyl [N-Term] cellular homeostasis;response to stimulus;transport cytosol;membrane catalytic activity;protein binding;transporter activity Pf03179 66290 ENSMUSG00000039105.6 Atp6v1g1 4 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High P35979 60S ribosomal protein L12 OS=Mus musculus OX=10090 GN=Rpl12 PE=1 SV=2 0 37.434 45 5 26 5 165 17.8 9.42 3 5 5 5 10 11 8855873.734 27016851 31332288.75 5 5 5 cell organization and biogenesis;metabolic process cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 269261 ENSMUSG00000038900.17 Rpl12 2 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q5SUA5 Unconventional myosin-Ig OS=Mus musculus OX=10090 GN=Myo1g PE=1 SV=1 0 32.993 12 9 26 7 1024 117.2 8.59 2 5 7 4 11 11 49443.50781 1746377.031 2247942.406 1 3 4 cellular component movement;regulation of biological process;response to stimulus;transport membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 246177 ENSMUSG00000020437.12 Myo1g 11 0 High P28825 Meprin A subunit alpha OS=Mus musculus OX=10090 GN=Mep1a PE=1 SV=4 0 67.939 25 13 26 13 747 84.2 6.24 5 7 9 5 8 13 5020172.578 24385255.38 39423886.56 10 12 12 metabolic process membrane catalytic activity;metal ion binding;protein binding "Pf00008, Pf00629, Pf00917, Pf01400" 17287 ENSMUSG00000023914.16 Mep1a 17 Protein digestion and absorption 0 High P11087 Collagen alpha-1(I) chain OS=Mus musculus OX=10090 GN=Col1a1 PE=1 SV=4 0 32.172 7 9 26 9 1453 137.9 5.85 2 8 6 3 12 11 5756676.75 25797539.63 55667071 7 8 8 cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi metal ion binding;protein binding;structural molecule activity "Pf00093, Pf01391, Pf01410" 12842 ENSMUSG00000001506.10 Col1a1 11 Anchoring fibril formation; ECM proteoglycans; Cell surface interactions at the vascular wall; Platelet Aggregation (Plug Formation); Integrin cell surface interactions; Collagen degradation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Crosslinking of collagen fibrils; Collagen chain trimerization; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; MET activates PTK2 signaling; GPVI-mediated activation cascade; Non-integrin membrane-ECM interactions AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Platelet activation; Proteoglycans in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High P18760 Cofilin-1 OS=Mus musculus OX=10090 GN=Cfl1 PE=1 SV=3 0 37.924 70 10 25 8 166 18.5 8.09 2 9 7 3 13 9 3908498.484 14046641 19441652.5 5 6 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus protein binding Pf00241 12631 ENSMUSG00000056201.7 Cfl1 19 Regulation of actin cytoskeleton; Axon guidance; Pertussis; Fc gamma R-mediated phagocytosis 1 High P15105 Glutamine synthetase OS=Mus musculus OX=10090 GN=Glul PE=1 SV=6 0 37.287 23 8 25 8 373 42.1 7.08 5 6 7 6 9 10 8402244.141 16965903 23073226.69 7 6 7 cell communication;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00120, Pf03951" 14645 ENSMUSG00000026473.15 Glul 1 Astrocytic Glutamate-Glutamine Uptake And Metabolism; Amino acid synthesis and interconversion (transamination) "GABAergic synapse; Metabolic pathways; Nitrogen metabolism; Biosynthesis of amino acids; Glutamatergic synapse; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis; Glyoxylate and dicarboxylate metabolism" 0 High P14869 60S acidic ribosomal protein P0 OS=Mus musculus OX=10090 GN=Rplp0 PE=1 SV=3 0 26.983 33 8 25 8 317 34.2 6.25 4 5 7 5 8 12 8063004.719 24438000.88 31144685.63 6 6 7 response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00428, Pf00466" 11837 ENSMUSG00000067274.10 Rplp0 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O08810 116 kDa U5 small nuclear ribonucleoprotein component OS=Mus musculus OX=10090 GN=Eftud2 PE=1 SV=1 0 62.323 21 15 25 15 971 109.3 5 1 9 12 1 10 14 415201.9766 17112835.69 21218444.63 3 12 13 metabolic process cytosol;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 20624 ENSMUSG00000020929.14 Eftud2 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P63038 "60 kDa heat shock protein, mitochondrial OS=Mus musculus OX=10090 GN=Hspd1 PE=1 SV=1" 0 47.144 22 12 25 12 573 60.9 6.18 3 10 8 3 12 10 6328926.602 23251392.38 37688655.31 10 10 11 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding Pf00118 15510 ENSMUSG00000025980.14 Hspd1 1 RNA degradation; Tuberculosis; Legionellosis; Type I diabetes mellitus 0 High Q9WV92 Band 4.1-like protein 3 OS=Mus musculus OX=10090 GN=Epb41l3 PE=1 SV=1 0 35.859 14 12 25 9 929 103.3 5.31 5 8 8 6 10 9 5781402.75 14610483.5 22020557.5 8 11 9 cell death;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" 13823 ENSMUSG00000024044.16 Epb4.1l3; Epb41l3 17 Neurexins and neuroligins Tight junction 3 High P19253 60S ribosomal protein L13a OS=Mus musculus OX=10090 GN=Rpl13a PE=1 SV=4 0 18.44 27 5 25 5 203 23.4 11.02 2 5 5 4 12 9 7510033.031 14831366.06 20662817.44 5 5 6 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00572 22121 ENSMUSG00000074129.13 Rpl13a 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9CX00 IST1 homolog OS=Mus musculus OX=10090 GN=Ist1 PE=1 SV=1 0 42.075 18 7 25 7 362 39.4 5.44 5 6 6 7 9 9 8162920.32 19585580.94 38045669.25 7 7 6 cell division;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;nucleus protein binding Pf03398 71955 ENSMUSG00000031729.6 Ist1 8 Neutrophil degranulation Endocytosis 0 High Q9CRC9 Glucosamine-6-phosphate isomerase 2 OS=Mus musculus OX=10090 GN=Gnpda2 PE=1 SV=1 0 59.886 63 11 25 9 276 31.1 6.9 10 7 14 11 46960.01172 23855169.91 28150890.38 1 8 9 metabolic process cytoplasm;nucleus catalytic activity Pf01182 67980 ENSMUSG00000029209.15 Gnpda2 5 Glycolysis Metabolic pathways; Amino sugar and nucleotide sugar metabolism 2 High Q9QWL7 "Keratin, type I cytoskeletal 17 OS=Mus musculus OX=10090 GN=Krt17 PE=1 SV=3" 0 23.524 15 9 25 3 433 48.1 5.06 8 3 4 13 5 7 85193464.88 25592665.42 34823700 8 6 6 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding;receptor activity;signal transducer activity;structural molecule activity "Pf00038, Pf01576, Pf07888" 16667 ENSMUSG00000035557.9 Krt17 11 Formation of the cornified envelope 5 High F7CPL2 Drebrin (Fragment) OS=Mus musculus OX=10090 GN=Dbn1 PE=1 SV=1 0 32.418 47 8 25 1 169 19.7 5.55 4 6 6 5 10 10 1232085.25 2288671.25 1 1 cell communication;cell differentiation;cell organization and biogenesis;cell proliferation cytoskeleton;membrane protein binding Pf00241 ENSMUSG00000034675.17 13 0 High Q9WUM5 "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Suclg1 PE=1 SV=4" 0 21.976 24 7 25 7 346 36.1 9.39 5 6 5 6 12 7 8120453.242 21567731.94 27721229.75 6 6 6 metabolic process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00549, Pf02629, Pf13607" 56451 ENSMUSG00000052738.14 Suclg1 6 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Propanoate metabolism; Carbon metabolism 0 High Q922B9 Protein ITPRID2 OS=Mus musculus OX=10090 GN=Itprid2 PE=1 SV=3 0 47.138 14 12 25 12 1252 136.9 5.26 4 9 10 4 9 12 5674401.953 12713743.84 23298541.38 9 10 11 cytoplasm;cytosol;membrane;nucleus protein binding "Pf14722, Pf14723" 70599 ENSMUSG00000027007.16 Ssfa2 2 0 High O54988 STE20-like serine/threonine-protein kinase OS=Mus musculus OX=10090 GN=Slk PE=1 SV=2 0 7.207 2 3 25 3 1233 141.4 5.14 1 2 3 9 7 9 2403889483 5024900225 2487279470 2 3 3 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12474, Pf14531" 20874 ENSMUSG00000025060.14 Slk 19 Oocyte meiosis 0 High Q9CPR4 60S ribosomal protein L17 OS=Mus musculus OX=10090 GN=Rpl17 PE=1 SV=3 0 42.019 42 7 25 7 184 21.4 10.18 6 6 6 6 10 9 8447357.281 18832561.94 21957811.25 7 7 6 metabolic process;regulation of biological process nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00237 319195 Rpl17 18 0 High Q9JM76 Actin-related protein 2/3 complex subunit 3 OS=Mus musculus OX=10090 GN=Arpc3 PE=1 SV=3 0 29.635 37 6 24 6 178 20.5 8.59 5 6 4 8 7 9 58212463.97 67325960.25 84129611.06 6 6 6 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity Pf04062 56378 ENSMUSG00000029465.14 Arpc3 5 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High A2AMW0 F-actin-capping protein subunit beta OS=Mus musculus OX=10090 GN=Capzb PE=1 SV=1 0 34.202 50 11 24 2 260 29.3 6.92 2 8 9 2 9 13 3541680.781 19639836.47 21846837.55 9 11 9 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding Pf01115 12345 ENSMUSG00000028745.18 Capzb 4 9 High P62874 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Mus musculus OX=10090 GN=Gnb1 PE=1 SV=3 0 53.226 39 11 24 5 340 37.4 6 3 9 8 3 10 11 5033715.125 8894021.625 15605285.81 4 4 5 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;regulation of biological process;response to stimulus membrane catalytic activity;protein binding;signal transducer activity Pf00400 14688 ENSMUSG00000029064.15 Gnb1 4 "Ca2+ pathway; G beta:gamma signalling through PI3Kgamma; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Thromboxane signalling through TP receptor; Olfactory Signaling Pathway; Presynaptic function of Kainate receptors; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon-type ligand receptors; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Prostacyclin signalling through prostacyclin receptor; Glucagon signaling in metabolic regulation; G-protein activation; Gastrin-CREB signalling pathway via PKC and MAPK; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Adrenaline,noradrenaline inhibits insulin secretion; Activation of G protein gated Potassium channels; ADP signalling through P2Y purinoceptor 1; G alpha (z) signalling events; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 12; Activation of the phototransduction cascade; G alpha (12/13) signalling events; Thrombin signalling through proteinase activated receptors (PARs)" Morphine addiction; Cholinergic synapse; Retrograde endocannabinoid signaling; Dopaminergic synapse; Ras signaling pathway; GABAergic synapse; Chemokine signaling pathway; Glutamatergic synapse; Pathways in cancer; Alcoholism; PI3K-Akt signaling pathway; Olfactory transduction; Phototransduction; Circadian entrainment; Serotonergic synapse 0 High Q6PB66 "Leucine-rich PPR motif-containing protein, mitochondrial OS=Mus musculus OX=10090 GN=Lrpprc PE=1 SV=2" 0 54.503 17 16 24 16 1392 156.5 6.83 3 8 11 3 9 12 4046775.344 11063143.72 12730723.75 8 11 10 metabolic process;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf12854, Pf13041, Pf13812" 72416 ENSMUSG00000024120.12 Lrpprc 17 0 High Q61656 Probable ATP-dependent RNA helicase DDX5 OS=Mus musculus OX=10090 GN=Ddx5 PE=1 SV=2 0 43.058 19 11 24 7 614 69.2 8.92 4 7 8 4 9 11 3045517.25 9953077.688 19314165.81 7 7 10 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08061" 13207 Ddx5 11 3 High P17751 Triosephosphate isomerase OS=Mus musculus OX=10090 GN=Tpi1 PE=1 SV=4 0 44.487 48 10 24 10 299 32.2 5.74 2 6 8 3 9 12 6285237.938 17207211.75 33404125.75 6 7 7 development;metabolic process cytosol;nucleus catalytic activity;protein binding Pf00121 21991 ENSMUSG00000023456.14 Tpi1 6 Gluconeogenesis; Glycolysis Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Inositol phosphate metabolism; Carbon metabolism; Fructose and mannose metabolism 0 High Q8VEK3 Heterogeneous nuclear ribonucleoprotein U OS=Mus musculus OX=10090 GN=Hnrnpu PE=1 SV=1 0 27.977 13 9 24 9 800 87.9 6.24 4 8 7 4 11 9 4691141.656 14628345.5 18630027.81 7 9 8 cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;nucleotide binding;protein binding;RNA binding "Pf00622, Pf13671" 51810 ENSMUSG00000039630.10; ENSMUSG00000111145.1 Hnrnpu 1; CHR_MG4281_PATCH mRNA Splicing - Major Pathway Spliceosome 0 High Q64475 Histone H2B type 1-B OS=Mus musculus OX=10090 GN=H2bc3 PE=1 SV=3 0 32.845 42 6 24 6 126 13.9 10.32 4 4 6 6 8 10 31033713.63 63853541.94 108528583.7 6 6 6 cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 319178 ENSMUSG00000075031.3 Hist1h2bb 13 HATs acetylate histones; E3 ubiquitin ligases ubiquitinate target proteins; Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus; Viral carcinogenesis 0 High Q9R0P5 Destrin OS=Mus musculus OX=10090 GN=Dstn PE=1 SV=3 0 39.514 51 10 24 9 165 18.5 7.97 4 7 7 5 11 8 8690286.625 27320842.56 36533861.56 7 10 9 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton protein binding Pf00241 56431 ENSMUSG00000015932.8 Dstn 2 1 High P19096 Fatty acid synthase OS=Mus musculus OX=10090 GN=Fasn PE=1 SV=2 0 83.427 14 21 24 21 2504 272.3 6.58 4 5 15 4 5 15 11169200.8 10368656.47 18997303.06 13 13 15 Acetyl [N-Term] cell differentiation;metabolic process;response to stimulus cytoplasm;cytosol;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08241, Pf08242, Pf08659, Pf12847, Pf13489, Pf13602, Pf13847, Pf14765" 14104 ENSMUSG00000025153.9 Fasn 11 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism Fatty acid metabolism; Insulin signaling pathway; Metabolic pathways; AMPK signaling pathway; Fatty acid biosynthesis 0 High P28798 Progranulin OS=Mus musculus OX=10090 GN=Grn PE=1 SV=2 0 49.277 22 7 24 7 589 63.4 6.8 5 5 6 8 6 10 20072451.56 45543124.5 36984207.63 7 8 7 cell proliferation;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;extracellular;mitochondrion;vacuole protein binding;RNA binding Pf00396 14824 Grn 11 0 High Q91VA7 "Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Mus musculus OX=10090 GN=Idh3b PE=1 SV=1" 0 44.234 38 12 24 12 384 42.2 8.6 6 6 7 8 8 8 8786238.375 26470469.83 38452279.88 9 11 10 metabolic process mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding Pf00180 170718 ENSMUSG00000027406.12 Idh3b 2 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism 0 High F8WHM5 Golgi apparatus protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Glg1 PE=1 SV=1 0 50.433 14 14 23 14 1163 132.3 6.93 8 7 6 8 8 7 8875353.063 11848677.72 13396317 13 11 10 regulation of biological process Golgi;membrane protein binding Pf00839 ENSMUSG00000003316.14 8 0 High P62281 40S ribosomal protein S11 OS=Mus musculus OX=10090 GN=Rps11 PE=1 SV=3 0 32.704 46 7 23 7 158 18.4 10.3 5 6 7 5 8 10 8075597.938 47945822.75 56176091.88 7 7 7 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process cytoplasm;membrane;ribosome RNA binding;structural molecule activity Pf00366 27207 ENSMUSG00000003429.11 Rps11 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q3ULB1 Testin OS=Mus musculus OX=10090 GN=Tes PE=1 SV=1 0 43.985 26 9 23 9 410 46.6 7.87 2 9 5 2 14 7 4133578.406 31918631.31 27984715.5 4 10 10 Met-loss [N-Term] regulation of biological process cytoplasm;cytosol;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00412, Pf06297" 21753 ENSMUSG00000029552.19 Tes 6 0 High Q62318 Transcription intermediary factor 1-beta OS=Mus musculus OX=10090 GN=Trim28 PE=1 SV=3 0 38.732 15 10 23 10 834 88.8 5.77 1 8 7 1 12 10 2980278.953 14213806.97 16529030.63 8 9 9 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00628, Pf00643" 21849 ENSMUSG00000005566.14 Trim28 7 Generic Transcription Pathway 0 High P19001 "Keratin, type I cytoskeletal 19 OS=Mus musculus OX=10090 GN=Krt19 PE=1 SV=1" 0 17.7 20 8 23 3 403 44.5 5.39 5 4 6 8 6 9 1329172.938 1568627.563 3858843 2 2 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoskeleton;membrane protein binding;structural molecule activity Pf00038 16669 ENSMUSG00000020911.14 Krt19 11 Formation of the cornified envelope 0 High Q8CBY8 Dynactin subunit 4 OS=Mus musculus OX=10090 GN=Dctn4 PE=1 SV=1 0 46.83 34 11 23 11 467 53 7.72 6 7 8 7 7 9 6988539.391 13491678.66 19501297.88 8 11 12 Met-loss+Acetyl [N-Term] chromosome;cytoplasm;cytoskeleton protein binding Pf05502 67665 Dctn4 18 COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Huntington's disease; Vasopressin-regulated water reabsorption 0 High Q9CPQ1 Cytochrome c oxidase subunit 6C OS=Mus musculus OX=10090 GN=Cox6c PE=1 SV=3 0 24.367 63 6 23 6 76 8.5 10.14 5 5 2 10 10 3 21748557.34 58293316.38 27085794 8 8 8 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02937 12864 ENSMUSG00000014313.14 Cox6c 15 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P70349 Histidine triad nucleotide-binding protein 1 OS=Mus musculus OX=10090 GN=Hint1 PE=1 SV=3 0 44.749 78 6 23 6 126 13.8 6.87 5 6 5 7 9 7 14070304.97 16363881.13 17751696.63 6 7 6 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding "Pf01230, Pf11969" 15254 ENSMUSG00000020267.6 Hint1 11 0 High Q8BVE3 V-type proton ATPase subunit H OS=Mus musculus OX=10090 GN=Atp6v1h PE=1 SV=1 0 66.091 37 13 23 13 483 55.8 6.61 1 9 9 1 10 12 3293136.023 36883913.53 37017853.25 7 12 11 cellular homeostasis;transport membrane catalytic activity;transporter activity "Pf03224, Pf11698" 108664 ENSMUSG00000033793.12 Atp6v1h 1 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Lysosome; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle 0 High P47757 F-actin-capping protein subunit beta OS=Mus musculus OX=10090 GN=Capzb PE=1 SV=3 0 35.633 46 10 23 1 277 31.3 5.74 2 8 9 2 9 12 381775.5 1304352.25 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding Pf01115 12345 ENSMUSG00000028745.18 Capzb 4 COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; Factors involved in megakaryocyte development and platelet production; HSP90 chaperone cycle for steroid hormone receptors (SHR) Endocytosis 0 High E9Q3M9 RIKEN cDNA 2010300C02 gene OS=Mus musculus OX=10090 GN=2010300C02Rik PE=1 SV=1 0.003 3.172 2 2 23 1 1175 125.8 7.37 1 1 2 3 11 9 68194840 84274544 64412592 1 1 1 Pf15262 72097 ENSMUSG00000026090.16 2010300C02Rik 1 0 High Q99NB1 "Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Mus musculus OX=10090 GN=Acss1 PE=1 SV=1" 0 45.474 28 14 23 14 682 74.6 6.98 3 7 10 3 8 12 4794241.633 20910537 24547075.94 11 13 13 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00501, Pf13193" 68738 ENSMUSG00000027452.11 Acss1 2 Ethanol oxidation Pyruvate metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis; Propanoate metabolism; Carbon metabolism 0 High Q6P3A8 "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Bckdhb PE=1 SV=2" 0 32.894 25 7 23 7 390 42.9 6.7 5 6 5 7 8 8 9350842.563 14279712.66 18752641.8 6 7 7 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf02779, Pf02780" 12040 ENSMUSG00000032263.14 Bckdhb 9 Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism" 0 High P62918 60S ribosomal protein L8 OS=Mus musculus OX=10090 GN=Rpl8 PE=1 SV=2 0 53.731 46 8 23 8 257 28 11.03 4 7 5 5 10 8 9217646.938 21857550.63 24969721.63 5 5 5 metabolic process;response to stimulus cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00181, Pf03947" 26961 ENSMUSG00000003970.8 Rpl8 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9WV69 Dematin OS=Mus musculus OX=10090 GN=Dmtn PE=1 SV=1 0 35.901 25 8 23 8 405 45.4 8.41 1 6 7 2 10 11 11983351.47 30002635.56 37041541.5 6 8 7 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding Pf02209 13829 Dmtn; Epb4.9 14 Miscellaneous transport and binding events 0 High A0A0N4SW28 Guanine nucleotide-binding protein subunit gamma OS=Mus musculus OX=10090 GN=Gng12 PE=1 SV=1 0 22.255 66 5 23 5 83 9.2 9.25 3 5 5 5 8 10 16808622.19 34539122.13 36257467.5 7 7 5 regulation of biological process;response to stimulus membrane signal transducer activity Pf00631 ENSMUSG00000036402.13 6 0 High Q61937 Nucleophosmin OS=Mus musculus OX=10090 GN=Npm1 PE=1 SV=1 0 57.218 39 10 23 10 292 32.5 4.77 5 8 6 6 9 8 21017293.59 38871317.13 63174216.25 7 8 8 Acetyl [N-Term] cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding Pf03066 18148 ENSMUSG00000057113.13 Npm1 11 0 High P26443 "Glutamate dehydrogenase 1, mitochondrial OS=Mus musculus OX=10090 GN=Glud1 PE=1 SV=1" 0 31.175 25 10 23 10 558 61.3 8 5 7 7 6 9 8 4519103.078 11257522.53 12293793.06 9 10 9 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00208, Pf02812" 14661 ENSMUSG00000021794.15 Glud1 14 Transcriptional activation of mitochondrial biogenesis; Amino acid synthesis and interconversion (transamination) "Metabolic pathways; Nitrogen metabolism; Proximal tubule bicarbonate reclamation; Carbon metabolism; D-Glutamine and D-glutamate metabolism; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis" 0 High Q922Q4 Pyrroline-5-carboxylate reductase 2 OS=Mus musculus OX=10090 GN=Pycr2 PE=1 SV=1 0 46.255 42 10 23 10 320 33.6 7.77 2 9 8 2 11 10 4725559.969 28644915.88 33135510.38 7 9 9 metabolic process;response to stimulus cytoplasm;mitochondrion catalytic activity;nucleotide binding "Pf01210, Pf03807, Pf10727, Pf14748" 69051 ENSMUSG00000026520.8 Pycr2 1 Amino acid synthesis and interconversion (transamination) Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids 0 High Q9Z2K1 "Keratin, type I cytoskeletal 16 OS=Mus musculus OX=10090 GN=Krt16 PE=1 SV=3" 0 29.155 16 9 23 5 469 51.6 5.2 9 2 2 16 4 3 40215937.94 10304880.63 13887627.75 8 4 3 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus cytoskeleton;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 16666 ENSMUSG00000053797.10 Krt16 11 Formation of the cornified envelope 3 High Q9D964 "Glycine amidinotransferase, mitochondrial OS=Mus musculus OX=10090 GN=Gatm PE=1 SV=1" 0 49.19 31 9 23 9 423 48.3 7.88 2 7 7 2 10 11 5130244.5 13339561.53 28797785.88 7 8 8 development;metabolic process;response to stimulus membrane;mitochondrion catalytic activity Pf02274 67092 ENSMUSG00000027199.14; ENSMUSG00000111138.1 Gatm 2; CHR_MG3836_PATCH Creatine metabolism "Arginine and proline metabolism; Metabolic pathways; Glycine, serine and threonine metabolism" 0 High E9Q9T1 Leucine-rich repeat flightless-interacting protein 1 OS=Mus musculus OX=10090 GN=Lrrfip1 PE=1 SV=2 0 50.898 21 10 22 5 628 71.1 5.83 3 9 6 4 11 7 5949081.172 15738312.52 24822620.19 7 9 9 metabolic process;regulation of biological process "Pf04111, Pf09738, Pf12128" ENSMUSG00000026305.15 1 4 High Q6IFZ6 "Keratin, type II cytoskeletal 1b OS=Mus musculus OX=10090 GN=Krt77 PE=1 SV=1" 0 17.082 6 3 22 1 572 61.3 8.02 3 3 3 7 7 8 31341798 13120765 11840570 1 1 1 cytoskeleton protein binding;structural molecule activity "Pf00038, Pf09728, Pf13166" 406220 ENSMUSG00000067594.5 Krt77 15 Formation of the cornified envelope 0 High P83940 Elongin-C OS=Mus musculus OX=10090 GN=Eloc PE=1 SV=1 0 31.139 66 6 22 6 112 12.5 4.78 5 4 4 8 6 8 18086966.88 25585445.13 40351570.63 6 6 6 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf03931 67923; 102642819 ENSMUSG00000079658.9 Tceb1; Eloc; LOC101056616; LOC102642819 1; 2 RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Interleukin-7 signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin mediated proteolysis; HIF-1 signaling pathway; Pathways in cancer; Renal cell carcinoma 0 High P61979 Heterogeneous nuclear ribonucleoprotein K OS=Mus musculus OX=10090 GN=Hnrnpk PE=1 SV=1 0 33.658 28 10 22 10 463 50.9 5.54 3 7 8 3 9 10 5465776.219 18389294.75 28024383 8 8 8 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00013, Pf08067, Pf13014, Pf13083" 15387 ENSMUSG00000021546.17 Hnrnpk 13 mRNA Splicing - Major Pathway Herpes simplex infection; MicroRNAs in cancer; Spliceosome; Viral carcinogenesis 0 High P54818 Galactocerebrosidase OS=Mus musculus OX=10090 GN=Galc PE=1 SV=2 0 47.226 22 9 22 9 684 77.2 6.74 5 8 5 6 9 7 14375661.13 27181144.88 28640923.5 9 9 9 metabolic process mitochondrion;vacuole catalytic activity Pf02057 14420 ENSMUSG00000021003.9 Galc 12 Glycosphingolipid metabolism Metabolic pathways; Lysosome; Sphingolipid metabolism 0 High P70451 Tyrosine-protein kinase Fer OS=Mus musculus OX=10090 GN=Fer PE=1 SV=2 0 54.728 21 13 22 13 823 94.5 7.05 9 8 11 11 533134.5547 16231121.06 21960897.47 4 11 10 cell communication;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00017, Pf00069, Pf00611, Pf07714" 14158 ENSMUSG00000000127.14 Fert2; Fer 17 Signaling by SCF-KIT Adherens junction 0 High P46412 Glutathione peroxidase 3 OS=Mus musculus OX=10090 GN=Gpx3 PE=1 SV=2 0 21.302 31 6 22 6 226 25.4 8.22 4 4 6 6 7 9 6127833.094 16616542 19392897 6 6 6 cell organization and biogenesis;metabolic process;response to stimulus extracellular antioxidant activity;catalytic activity Pf00255 14778 ENSMUSG00000018339.11 Gpx3 11 Detoxification of Reactive Oxygen Species Glutathione metabolism; Thyroid hormone synthesis; Arachidonic acid metabolism 0 High Q99MR8 "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Mccc1 PE=1 SV=2" 0 60.643 29 13 22 13 717 79.3 7.83 4 7 10 4 8 10 8169720.844 18288279.59 22996122.53 9 11 11 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding "Pf00289, Pf00364, Pf01071, Pf02222, Pf02785, Pf02786, Pf07478, Pf13533, Pf13535, Pf15632" 72039 ENSMUSG00000027709.9 Mccc1 3 Biotin transport and metabolism; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways" 0 High Q9CZM2 60S ribosomal protein L15 OS=Mus musculus OX=10090 GN=Rpl15 PE=1 SV=4 0 26.867 46 9 22 9 204 24.1 11.62 5 8 6 5 9 8 7673319.188 17982089.13 27484169 6 8 7 metabolic process membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00827 66480 ENSMUSG00000012405.15 Rpl15 14 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P51410 60S ribosomal protein L9 OS=Mus musculus OX=10090 GN=Rpl9 PE=2 SV=2 0 32.326 39 8 21 8 192 21.9 9.95 2 6 6 2 8 11 4722654.5 18070596.41 23410964 6 6 5 metabolic process membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00347 20005 ENSMUSG00000047215.14 Rpl9 5 Ribosome 0 High Q8CI94 "Glycogen phosphorylase, brain form OS=Mus musculus OX=10090 GN=Pygb PE=1 SV=3" 0 56.111 21 14 21 11 843 96.7 6.73 5 13 5 16 1614938.422 10450460.39 26356804.38 8 13 14 metabolic process cytoplasm;membrane catalytic activity;protein binding Pf00343 110078 ENSMUSG00000033059.7 Pygb 2 Neutrophil degranulation Insulin signaling pathway; Metabolic pathways; Insulin resistance; Starch and sucrose metabolism; Glucagon signaling pathway 3 High A0A1W2P7F1 "Complement component 1, s subcomponent 2 OS=Mus musculus OX=10090 GN=C1s2 PE=3 SV=1" 0 36.608 12 7 21 1 694 77.2 4.94 4 5 5 6 8 7 1929497.813 1383982 1758952 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular catalytic activity;metal ion binding;protein binding "Pf00084, Pf00089, Pf00431, Pf07645, Pf14670" 317677 ENSMUSG00000079343.4 Gm5077; C1s2 6 Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Systemic lupus erythematosus 0 High Q8BSH9 Nucleosome assembly protein 1-like 1 OS=Mus musculus OX=10090 GN=Nap1l1 PE=1 SV=1 0 41.281 26 6 21 5 383 44.6 4.56 2 4 5 5 5 11 5050958.438 9840016.625 8668258 4 4 3 cell organization and biogenesis cytoplasm;membrane;nucleus protein binding;RNA binding Pf00956 53605 ENSMUSG00000058799.15 Nap1l1 10 0 High Q9DC51 Guanine nucleotide-binding protein G(i) subunit alpha OS=Mus musculus OX=10090 GN=Gnai3 PE=1 SV=3 0 37.935 30 9 21 5 354 40.5 5.69 3 6 7 3 7 11 1677704.031 4089828.313 5356145 4 3 3 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;Golgi;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503" 14679 ENSMUSG00000000001.4 Gnai3 3 PLC beta mediated events; ADP signalling through P2Y purinoceptor 12; Adenylate cyclase inhibitory pathway; G-protein activation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Oxytocin signaling pathway; Leukocyte transendothelial migration; Morphine addiction; Cholinergic synapse; Chagas disease (American trypanosomiasis); Retrograde endocannabinoid signaling; Dopaminergic synapse; Progesterone-mediated oocyte maturation; GABAergic synapse; Regulation of lipolysis in adipocytes; Toxoplasmosis; Chemokine signaling pathway; Platelet activation; Melanogenesis; Axon guidance; Sphingolipid signaling pathway; Glutamatergic synapse; Pertussis; Parkinson's disease; Cocaine addiction; Long-term depression; cGMP-PKG signaling pathway; Rap1 signaling pathway; Pathways in cancer; Alcoholism; cAMP signaling pathway; Tight junction; Gastric acid secretion; Renin secretion; Gap junction; Circadian entrainment; Estrogen signaling pathway; Serotonergic synapse; Adrenergic signaling in cardiomyocytes 0 High Q9D1M0 Protein SEC13 homolog OS=Mus musculus OX=10090 GN=Sec13 PE=1 SV=3 0 37.843 50 10 21 10 322 35.5 5.38 3 6 8 3 7 11 12329036.29 24535733 32883468.38 9 10 9 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport chromosome;cytosol;endoplasmic reticulum;membrane;nucleus;vacuole protein binding Pf00400 110379 ENSMUSG00000030298.10 Sec13 6 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; RHO GTPases Activate Formins; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; COPII (Coat Protein 2) Mediated Vesicle Transport" mTOR signaling pathway; RNA transport; Protein processing in endoplasmic reticulum 0 High Q6IFX2 "Keratin, type I cytoskeletal 42 OS=Mus musculus OX=10090 GN=Krt42 PE=1 SV=1" 0 26.424 18 9 21 4 452 50.1 5.16 6 2 6 10 3 8 22846851.42 2618904.5 5448537.75 4 1 3 cytoplasm structural molecule activity "Pf00038, Pf04156, Pf08317, Pf13166, Pf13514" 68239 ENSMUSG00000053654.7 Krt42 11 0 High Q61503 5'-nucleotidase OS=Mus musculus OX=10090 GN=Nt5e PE=1 SV=2 0 50.886 26 9 21 9 576 63.8 6.64 2 6 8 2 7 12 3317522.898 12243485.19 13661952.25 5 6 6 metabolic process;regulation of biological process cell surface;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding "Pf00149, Pf02872, Pf09587" 23959 ENSMUSG00000032420.8 Nt5e 9 Nicotinate metabolism; Purine catabolism; Pyrimidine catabolism Metabolic pathways; Nicotinate and nicotinamide metabolism; Purine metabolism; Pyrimidine metabolism 0 High B1AU25 "Apoptosis-inducing factor 1, mitochondrial OS=Mus musculus OX=10090 GN=Aifm1 PE=1 SV=1" 0 47.963 23 10 21 10 608 66.1 9.11 4 6 7 5 7 9 7573663.008 15972485.5 24516718 10 10 11 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00070, Pf07992, Pf14721, Pf14962" 26926 ENSMUSG00000036932.14 Aifm1 X 0 High A0A087WQ89 MISP family member 3 OS=Mus musculus OX=10090 GN=Misp3 PE=1 SV=1 0 28.564 36 6 21 6 206 23.2 10.73 1 6 5 1 11 9 5338645.813 24720518.5 33372769.13 6 7 7 Acetyl [N-Term] Pf15304 70134 ENSMUSG00000074217.8 2210011C24Rik 8 0 High F7AEH4 40S ribosomal protein S12 OS=Mus musculus OX=10090 GN=Rps12 PE=1 SV=1 0 30.777 61 7 21 7 137 15.2 8.35 2 5 6 2 9 10 2903637.203 14585497.47 23601607.42 5 6 7 Met-loss+Acetyl [N-Term] metabolic process cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01248 20042 ENSMUSG00000061983.7 Rps12 10 0 High P26039 Talin-1 OS=Mus musculus OX=10090 GN=Tln1 PE=1 SV=2 0 61.825 10 15 21 15 2541 269.7 6.18 8 13 8 13 64422521.62 59849734.05 67424403.31 8 12 9 cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379" 21894 ENSMUSG00000028465.16 Tln1 4 p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Platelet degranulation ; Smooth Muscle Contraction Focal adhesion; Platelet activation; HTLV-I infection; Rap1 signaling pathway 0 High Q9CQA3 "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Mus musculus OX=10090 GN=Sdhb PE=1 SV=1" 0 27.847 35 10 21 10 282 31.8 8.68 3 9 8 3 10 8 6085042.422 14634886.14 14457923.66 8 9 8 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding "Pf13085, Pf13183, Pf13534" 67680 ENSMUSG00000009863.14 Sdhb 4 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Carbon metabolism 0 High O54724 Caveolae-associated protein 1 OS=Mus musculus OX=10090 GN=Cavin1 PE=1 SV=1 0 40.799 24 8 21 8 392 43.9 5.52 4 7 6 4 9 8 7620763.531 10713128.31 23764643.06 7 8 8 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus protein binding;RNA binding Pf15237 19285 ENSMUSG00000004044.9 Ptrf; Cavin1 11 RNA Polymerase I Transcription Termination 0 High Q3UZ39 Leucine-rich repeat flightless-interacting protein 1 OS=Mus musculus OX=10090 GN=Lrrfip1 PE=1 SV=2 0 34.873 12 7 21 2 729 79.2 4.82 2 6 6 3 8 10 1786330.531 4126438.25 7351196.125 2 2 2 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding Pf09738 16978 ENSMUSG00000026305.15 Lrrfip1 1 0 High P80317 T-complex protein 1 subunit zeta OS=Mus musculus OX=10090 GN=Cct6a PE=1 SV=3 0 47.341 27 11 20 11 531 58 7.08 2 8 8 2 8 10 2235692.241 10120229.59 13036365.75 8 10 10 metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane nucleotide binding;protein binding;RNA binding "Pf00118, Pf05504" 12466 Cct6a 5 0 High A0A3B2WDD2 Ribosomal protein OS=Mus musculus OX=10090 GN=Rpl10a PE=1 SV=1 0 37.024 46 9 20 9 190 21.6 9.98 2 6 6 2 8 10 9224228.125 27380664.88 40271153.75 8 9 8 0 High P68254 14-3-3 protein theta OS=Mus musculus OX=10090 GN=Ywhaq PE=1 SV=1 0 53.718 50 12 20 10 245 27.8 4.78 1 7 10 1 7 12 9535745.438 21180822.09 40834020.19 7 9 11 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane catalytic activity;DNA binding;protein binding Pf00244 22630; 102634437; 214444 ENSMUSG00000076432.12 Ywhaq; LOC102634437; Gm11226; Ywhaq-ps3; Cdk5rap2 12; 4 Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Epstein-Barr virus infection; Hippo signaling pathway; Hepatitis B; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 2 High P05784 "Keratin, type I cytoskeletal 18 OS=Mus musculus OX=10090 GN=Krt18 PE=1 SV=5" 0 18.207 20 7 20 5 423 47.5 5.33 3 6 4 6 8 6 1249657.594 2683017.406 5498195.75 2 4 4 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;structural molecule activity Pf00038 16668 ENSMUSG00000023043.6 Krt18 15 Formation of the cornified envelope 0 High P50446 "Keratin, type II cytoskeletal 6A OS=Mus musculus OX=10090 GN=Krt6a PE=1 SV=3" 0 30.067 15 10 20 2 553 59.3 7.94 9 3 3 14 3 3 62779735.88 33847687.91 34131683.66 10 8 8 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf05957, Pf12128, Pf13166" 16687 ENSMUSG00000058354.6 Krt6a 15 Formation of the cornified envelope 8 High A0A1L1SU70 Tropomodulin-2 OS=Mus musculus OX=10090 GN=Tmod2 PE=1 SV=1 0 28.826 50 7 20 6 248 27.8 4.92 1 4 7 2 7 11 886984.3438 3674357.938 10523286.69 4 5 6 cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton protein binding Pf03250 50876 ENSMUSG00000032186.15 Tmod2 9 0 High Q02257 Junction plakoglobin OS=Mus musculus OX=10090 GN=Jup PE=1 SV=3 0 47.322 26 13 20 10 745 81.7 6.14 7 5 6 7 5 8 3904229.883 8750227.563 5530167.594 7 6 6 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;signal transducer activity;structural molecule activity Pf00514 16480 ENSMUSG00000001552.14 Jup 11 Formation of the cornified envelope; VEGFR2 mediated vascular permeability; Neutrophil degranulation; Adherens junctions interactions Acute myeloid leukemia; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Transcriptional misregulation in cancer; Pathways in cancer 0 High P97434 Myosin phosphatase Rho-interacting protein OS=Mus musculus OX=10090 GN=Mprip PE=1 SV=2 0 50.925 16 12 20 12 1024 116.3 6.21 3 8 7 3 8 9 3101301.301 14018660.88 20209989.44 7 11 11 regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding Pf00169 26936 ENSMUSG00000005417.17 Mprip 11 0 High Q8BFZ9 Erlin-2 OS=Mus musculus OX=10090 GN=Erlin2 PE=1 SV=1 0 42.694 43 11 20 8 340 37.8 5.5 5 9 4 5 11 4 7448116.734 23950638.63 14403993.88 10 11 10 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;membrane protein binding Pf01145 244373 ENSMUSG00000031483.8 Erlin2 8 ABC-family proteins mediated transport 3 High Q91V77 Protein S100 OS=Mus musculus OX=10090 GN=S100a1 PE=1 SV=1 0 51.676 64 5 20 5 94 10.5 4.59 4 4 5 4 6 10 21305923.38 68031682.75 70029478.38 5 4 5 Met-loss+Acetyl [N-Term] regulation of biological process cytoplasm;endoplasmic reticulum;nucleus metal ion binding;protein binding Pf01023 20193 ENSMUSG00000044080.9 S100a1 3 Regulation of TLR by endogenous ligand 0 High A2AJ88 Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 0 47.571 13 13 20 10 1352 150.4 6.92 10 8 11 9 52901.90234 11356403.25 7435670.875 1 7 5 metabolic process endoplasmic reticulum;membrane;mitochondrion;nucleus;vacuole catalytic activity "Pf00027, Pf01734" 241274 ENSMUSG00000036833.16 Pnpla7 2 Glycerophospholipid metabolism 0 High Q9DCV7 "Keratin, type II cytoskeletal 7 OS=Mus musculus OX=10090 GN=Krt7 PE=1 SV=1" 0 32.12 26 11 20 9 457 50.7 5.87 2 7 6 5 8 7 9375611.75 8554565.844 10159646.63 7 9 8 cell organization and biogenesis;transport cytoplasm;cytoskeleton;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf06160, Pf07926, Pf08317, Pf11559, Pf12128, Pf12137, Pf13166, Pf13514" 110310 ENSMUSG00000023039.16 Krt7 15 Formation of the cornified envelope 1 High P62082 40S ribosomal protein S7 OS=Mus musculus OX=10090 GN=Rps7 PE=2 SV=1 0 57.995 46 7 20 7 194 22.1 10.1 2 6 6 2 8 10 21085554.56 45892185.88 51322069.13 6 7 7 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01251 20115 ENSMUSG00000061477.3 Rps7 12 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High A0A0G2JGD2 Protein S100-A4 (Fragment) OS=Mus musculus OX=10090 GN=S100a4 PE=1 SV=1 0 22.425 56 5 19 5 78 9.1 5.21 1 5 3 1 10 8 5714125.25 78790310.5 85400900.75 4 4 4 Met-loss+Acetyl [N-Term] metal ion binding;protein binding Pf01023 ENSMUSG00000001020.8 3 0 High Q61136 Serine/threonine-protein kinase PRP4 homolog OS=Mus musculus OX=10090 GN=Prpf4b PE=1 SV=3 0 40.75 11 11 19 11 1007 116.9 10.23 8 9 10 9 164564.4453 27603187.91 34169314.06 2 9 8 Met-loss+Acetyl [N-Term] metabolic process chromosome;nucleus;spliceosomal complex catalytic activity;nucleotide binding;RNA binding "Pf00069, Pf07714" 19134 ENSMUSG00000021413.8 Prpf4b 13 0 High P49222 Erythrocyte membrane protein band 4.2 OS=Mus musculus OX=10090 GN=Epb42 PE=1 SV=3 0 45.667 23 11 19 11 691 76.7 7.31 1 10 7 1 10 8 2430478.875 13528823.09 13623144.64 7 10 10 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane catalytic activity "Pf00868, Pf00927, Pf01841" 13828 ENSMUSG00000023216.13 Epb4.2; Epb42 2 0 High Q9D3A8 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Mus musculus OX=10090 GN=Nos1ap PE=1 SV=3 0 29.126 15 7 19 7 503 55.8 6.09 6 6 4 7 8 4 9350687.25 14085888.94 14086841.88 7 7 7 regulation of biological process cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding Pf00640 70729 ENSMUSG00000038473.14 Nos1ap 1 Circadian entrainment 0 High O88958 Glucosamine-6-phosphate isomerase 1 OS=Mus musculus OX=10090 GN=Gnpda1 PE=1 SV=3 0 40.401 44 9 19 7 289 32.5 6.6 8 7 11 8 185648.2813 14989097.38 15108816 1 5 6 metabolic process;transport cytoplasm catalytic activity Pf01182 26384 ENSMUSG00000052102.14 Gnpda1 18 Glycolysis Metabolic pathways; Amino sugar and nucleotide sugar metabolism 0 High Q99M28 RNA-binding protein with serine-rich domain 1 OS=Mus musculus OX=10090 GN=Rnps1 PE=1 SV=1 0 27.563 23 5 19 5 305 34.2 11.84 1 4 4 1 10 8 311795.0703 19116343.75 13634291.94 2 6 5 metabolic process;regulation of biological process cytoplasm;nucleus RNA binding "Pf00076, Pf08777, Pf11608, Pf13893, Pf14259" 19826 ENSMUSG00000034681.16 Rnps1 17 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; RNA transport 0 High D4AFX7 DnaJ heat shock protein family (Hsp40) member C13 OS=Mus musculus OX=10090 GN=Dnajc13 PE=1 SV=1 0 38.314 9 15 19 15 2248 254.9 6.77 3 5 11 3 5 11 3590297.203 11779442.78 15388823.19 10 11 12 cell differentiation;cell organization and biogenesis;regulation of biological process;transport cytosol;membrane "Pf00226, Pf14237" 235567 ENSMUSG00000032560.14 Dnajc13 9 Neutrophil degranulation 0 High P12382 "ATP-dependent 6-phosphofructokinase, liver type OS=Mus musculus OX=10090 GN=Pfkl PE=1 SV=4" 0 51.46 25 12 19 9 780 85.3 7.17 2 6 9 2 6 11 3283094.641 9607900.781 17972146.69 8 9 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 18641 ENSMUSG00000020277.10 Pfkl 10 Neutrophil degranulation; Glycolysis RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Pentose phosphate pathway; HIF-1 signaling pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 3 High Q641P0 Actin-related protein 3B OS=Mus musculus OX=10090 GN=Actr3b PE=1 SV=1 0 16.808 8 3 19 1 418 47.5 6.02 3 3 2 8 6 5 6772063 9946983 14536486 1 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton nucleotide binding;protein binding Pf00022 242894 ENSMUSG00000056367.14 Actr3b 5 0 High Q3V0K9 Plastin-1 OS=Mus musculus OX=10090 GN=Pls1 PE=1 SV=1 0 32.69 13 7 19 4 630 70.4 5.38 1 6 4 4 7 8 2849966.906 5264321.344 8144283.188 4 4 4 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton metal ion binding;protein binding "Pf00036, Pf00307, Pf13405, Pf13499, Pf13833" 102502 ENSMUSG00000049493.13 Pls1 9 0 High Q9D898 Actin-related protein 2/3 complex subunit 5-like protein OS=Mus musculus OX=10090 GN=Arpc5l PE=1 SV=1 0 36.928 59 5 19 5 153 17 6.8 2 4 5 3 7 9 15732568.38 27838403.56 34341138.13 6 6 5 cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton protein binding Pf04699 74192 ENSMUSG00000026755.14 Arpc5l 2 Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 High Q3TTY5 "Keratin, type II cytoskeletal 2 epidermal OS=Mus musculus OX=10090 GN=Krt2 PE=1 SV=1" 0 16.191 5 5 19 3 707 70.9 8.06 4 4 3 7 8 4 25439571 22358768.5 17189916.75 4 4 4 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process cytoskeleton;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf13166" 16681 ENSMUSG00000064201.8 Krt2 15 Formation of the cornified envelope 0 High I7HLV2 60S ribosomal protein L10 (Fragment) OS=Mus musculus OX=10090 GN=Rpl10 PE=1 SV=1 0 26.74 36 6 19 6 201 23.1 10.01 4 5 5 5 7 7 4380228.938 12624451 21299569.38 5 5 6 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00252 110954 ENSMUSG00000008682.13 Rpl10 X 0 High P19536 "Cytochrome c oxidase subunit 5B, mitochondrial OS=Mus musculus OX=10090 GN=Cox5b PE=1 SV=1" 0 15.472 29 4 19 4 128 13.8 8.38 4 3 2 6 10 3 10724854.3 20874100.41 18939754.63 5 4 4 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;transporter activity Pf01215 12859 Cox5b 1 0 High P50543 Protein S100-A11 OS=Mus musculus OX=10090 GN=S100a11 PE=1 SV=1 0 35.504 84 6 19 6 98 11.1 5.45 2 6 5 3 9 7 7163344.281 26236270.13 22939004.38 5 6 6 regulation of biological process cytoplasm;extracellular;nucleus metal ion binding;protein binding "Pf00036, Pf01023, Pf13499, Pf13833" 20195 ENSMUSG00000027907.4 S100a11 3 Neutrophil degranulation 0 High P26043 Radixin OS=Mus musculus OX=10090 GN=Rdx PE=1 SV=3 0 25.818 15 9 18 3 583 68.5 6.2 4 6 3 5 8 5 268957.5938 1271114.813 650859.875 1 2 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane protein binding;RNA binding "Pf00373, Pf00769, Pf09379, Pf09380" 19684 ENSMUSG00000032050.17 Rdx 9 Regulation of actin cytoskeleton; MicroRNAs in cancer; Proteoglycans in cancer 0 High P84104 Serine/arginine-rich splicing factor 3 OS=Mus musculus OX=10090 GN=Srsf3 PE=1 SV=1 0 24.146 40 6 18 5 164 19.3 11.65 4 4 6 5 6 7 6911932.219 37057062.81 52151341.25 4 5 6 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 20383 ENSMUSG00000071172.12 Srsf3 17 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 1 High P35980 60S ribosomal protein L18 OS=Mus musculus OX=10090 GN=Rpl18 PE=1 SV=3 0 17.657 34 6 18 6 188 21.6 11.78 4 5 2 7 7 4 8893150.563 26971641.5 34351023.25 5 5 5 metabolic process cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00828 19899 ENSMUSG00000059070.16 Rpl18 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62751 60S ribosomal protein L23a OS=Mus musculus OX=10090 GN=Rpl23a PE=1 SV=1 0 16.942 32 5 18 5 156 17.7 10.45 4 5 3 4 9 5 4189093.75 17939602.13 13938631.38 4 5 4 cell organization and biogenesis;metabolic process nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00276, Pf03939" 268449 ENSMUSG00000058546.8 Rpl23a 11 Ribosome 0 High Q8CGK3 "Lon protease homolog, mitochondrial OS=Mus musculus OX=10090 GN=Lonp1 PE=1 SV=2" 0 49.926 25 13 18 13 949 105.8 6.57 1 5 11 1 5 12 1109007.91 9228042.813 15955268.16 5 10 12 cell organization and biogenesis;metabolic process;response to stimulus cytosol;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01695, Pf02190, Pf05362, Pf05496, Pf07724, Pf07726, Pf07728, Pf08298, Pf13173, Pf13191, Pf13207, Pf13401, Pf13541" 74142 ENSMUSG00000041168.9 Lonp1 17 0 High P04104 "Keratin, type II cytoskeletal 1 OS=Mus musculus OX=10090 GN=Krt1 PE=1 SV=4" 0 18.97 4 3 18 2 637 65.6 8.15 2 3 3 6 5 7 67690873.63 52456687.19 69424376.5 4 5 5 defense response;metabolic process;regulation of biological process;response to stimulus cytoskeleton;membrane;nucleus structural molecule activity "Pf00038, Pf11853" 16678 ENSMUSG00000046834.6 Krt1 15 Formation of the cornified envelope; Neutrophil degranulation 2 High P43277 Histone H1.3 OS=Mus musculus OX=10090 GN=H1-3 PE=1 SV=2 0 25.333 35 8 18 1 221 22.1 11.03 5 4 6 6 4 8 14039039.72 27437418 57480543 7 6 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 14957 ENSMUSG00000052565.6 Hist1h1d 13 7 High Q5SUH7 Clathrin interactor 1 OS=Mus musculus OX=10090 GN=Clint1 PE=1 SV=1 0 29.706 17 9 18 9 623 67.7 6.42 6 6 3 7 7 4 11965063.28 10060444.19 8349674.344 8 8 6 cell organization and biogenesis;transport cytoplasm;Golgi;membrane protein binding "Pf01417, Pf07651" 216705 ENSMUSG00000006169.19 Clint1 11 Golgi Associated Vesicle Biogenesis 0 High P63101 14-3-3 protein zeta/delta OS=Mus musculus OX=10090 GN=Ywhaz PE=1 SV=1 0 42.306 41 9 18 7 245 27.8 4.79 2 6 7 2 7 9 2944915.156 11798664.72 10305970.56 4 6 5 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding;RNA binding Pf00244 22631 ENSMUSG00000022285.16 Ywhaz 15 "Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; Deactivation of the beta-catenin transactivating complex; RHO GTPases activate PKNs; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Interleukin-3, 5 and GM-CSF signaling" Epstein-Barr virus infection; Hippo signaling pathway; Hepatitis B; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High A0A0R4J203 D-amino-acid oxidase OS=Mus musculus OX=10090 GN=Dao PE=1 SV=1 0 42.13 29 7 18 7 345 38.6 7.36 4 4 6 4 5 9 3992559.531 15426998.5 25397412.25 4 6 6 metabolic process cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf01266, Pf03721" 13142 ENSMUSG00000042096.15 Dao 5 Glyoxylate metabolism and glycine degradation "Arginine and proline metabolism; D-Arginine and D-ornithine metabolism; Metabolic pathways; Glycine, serine and threonine metabolism; Peroxisome" 0 High A0A0A6YVP0 Immunoglobulin heavy constant gamma 2B (Fragment) OS=Mus musculus OX=10090 GN=Ighg2b PE=1 SV=2 0 26.389 10 4 18 3 405 44.3 6.52 3 1 4 9 2 7 8520311.625 6538551.125 15841840 3 3 3 membrane "Pf07654, Pf08205" 0 High Q9QZB7 Actin-related protein 10 OS=Mus musculus OX=10090 GN=Actr10 PE=1 SV=2 0 52.715 37 11 18 11 417 46.2 7.61 4 6 6 4 7 7 7608659.344 13583491.88 19355069.66 6 6 7 Met-loss [N-Term] cellular component movement cytoplasm;cytoskeleton protein binding Pf00022 56444 ENSMUSG00000021076.5 Actr10 12 COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) 0 High P14131 40S ribosomal protein S16 OS=Mus musculus OX=10090 GN=Rps16 PE=1 SV=4 0 21.73 50 8 18 8 146 16.4 10.21 5 5 7 5 6 7 5710435.344 15589114 22522051.69 8 8 8 metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00380 100039355; 20055 ENSMUSG00000037563.15 Rps16-ps2; Rps16 5; 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q8CGP7 Histone H2A type 1-K OS=Mus musculus OX=10090 GN=H2ac15 PE=1 SV=3 0 18.682 38 5 17 1 130 14.1 11.05 4 3 5 6 6 5 27725.58008 39430.9375 166958.3281 1 1 1 regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 319169 ENSMUSG00000063021.3 Hist1h2ak 13 Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus 0 High Q80XN0 "D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Bdh1 PE=1 SV=2" 0 40.311 38 9 17 9 343 38.3 9.01 1 6 6 1 6 10 2307059.031 10391005.13 9246061.875 4 8 5 metabolic process membrane;mitochondrion;organelle lumen catalytic activity "Pf00106, Pf08643, Pf13561" 71911 ENSMUSG00000046598.14 Bdh1 16 Synthesis of Ketone Bodies; Utilization of Ketone Bodies Metabolic pathways; Butanoate metabolism; Synthesis and degradation of ketone bodies 0 High Q3TWW8 Serine/arginine-rich splicing factor 6 OS=Mus musculus OX=10090 GN=Srsf6 PE=1 SV=1 0 19.884 17 6 17 4 339 39 11.46 1 6 6 1 10 6 1135575.234 13071728.75 11312357.88 3 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 67996 ENSMUSG00000016921.14 Srsf6 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High A0A1Y7VJN6 Immunoglobulin heavy constant gamma 3 (Fragment) OS=Mus musculus OX=10090 GN=Ighg3 PE=4 SV=1 0 15.934 15 5 17 5 399 44 7.14 4 4 4 5 4 8 38191621.86 51341689.5 183742153.6 6 4 6 membrane "Pf07654, Pf08205" 0 High Q8R5C5 Beta-centractin OS=Mus musculus OX=10090 GN=Actr1b PE=1 SV=1 0 53.769 44 10 17 5 376 42.3 6.4 6 8 6 11 4312690.313 12320228.88 23074448.75 6 8 10 cytoplasm;cytoskeleton;membrane nucleotide binding Pf00022 226977 ENSMUSG00000037351.9 Actr1b 1 MHC class II antigen presentation; Neutrophil degranulation 5 High Q9Z0K8 Pantetheinase OS=Mus musculus OX=10090 GN=Vnn1 PE=1 SV=3 0 44.424 25 8 17 8 512 57.1 5.94 4 6 5 4 7 6 4527249.75 19031856.63 16478022.56 6 7 7 defense response;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity Pf00795 22361 ENSMUSG00000037440.8 Vnn1 10 Post-translational modification: synthesis of GPI-anchored proteins; Neutrophil degranulation; Vitamin B5 (pantothenate) metabolism Pantothenate and CoA biosynthesis 0 High P62983 Ubiquitin-40S ribosomal protein S27a OS=Mus musculus OX=10090 GN=Rps27a PE=1 SV=2 0 21.787 46 6 17 6 156 17.9 9.64 2 5 4 2 8 7 3297643.188 9103001.75 11821619.5 5 5 5 metabolic process cytoplasm;cytosol;membrane;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00240, Pf01599, Pf11976, Pf13019, Pf13881, Pf14560" 78294; 619900; 100042019 ENSMUSG00000020460.15 Rps27a; Rps27a-ps2; LOC100042019 11; 9 "Termination of translesion DNA synthesis; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; NOD1/2 Signaling Pathway; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Ovarian tumor domain proteases; UCH proteinases; Stimuli-sensing channels; p75NTR recruits signalling complexes; Josephin domain DUBs; Spry regulation of FGF signaling; SRP-dependent cotranslational protein targeting to membrane; Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Activation of NF-kappaB in B cells; EGFR downregulation; Regulation of necroptotic cell death; Regulation of signaling by CBL; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Formation of a pool of free 40S subunits; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; NF-kB is activated and signals survival; Downstream TCR signaling; Association of licensing factors with the pre-replicative complex; Autodegradation of Cdh1 by Cdh1:APC/C; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Asymmetric localization of PCP proteins; Interleukin-1 family signaling; TNFR1-induced NFkappaB signaling pathway; G2/M Checkpoints; Regulation of PTEN localization; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Mus musculus biological processes; Regulation of PTEN stability and activity; APC-Cdc20 mediated degradation of Nek2A; Formation of the ternary complex, and subsequently, the 43S complex; Regulation of TP53 Activity through Methylation; E3 ubiquitin ligases ubiquitinate target proteins; Translesion synthesis by POLI; Interleukin-20 family signaling; Downregulation of ERBB4 signaling; Dual Incision in GG-NER; ER Quality Control Compartment (ERQC); Neddylation; Negative regulators of DDX58/IFIH1 signaling; Gap-filling DNA repair synthesis and ligation in TC-NER; APC/C:Cdc20 mediated degradation of Securin; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Oxidative Stress Induced Senescence; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Regulation of PLK1 Activity at G2/M Transition; Senescence-Associated Secretory Phenotype (SASP); Oncogene Induced Senescence; Formation of TC-NER Pre-Incision Complex; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; APC/C:Cdc20 mediated degradation of Cyclin B; Translation initiation complex formation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of FZD by ubiquitination; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Circadian Clock; Degradation of DVL; Degradation of AXIN; The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Endosomal Sorting Complex Required For Transport (ESCRT); Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Degradation of beta-catenin by the destruction complex; NRIF signals cell death from the nucleus; Autodegradation of the E3 ubiquitin ligase COP1; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; Regulation of innate immune responses to cytosolic DNA; GLI3 is processed to GLI3R by the proteasome; Translesion synthesis by POLK; Activated TLR4 signalling; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); DNA Damage Recognition in GG-NER; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Formation of Incision Complex in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Hedgehog ligand biogenesis; Regulation of RAS by GAPs; Activated NOTCH1 Transmits Signal to the Nucleus; Cyclin D associated events in G1; Dual incision in TC-NER; Negative regulation of MAPK pathway; Pink/Parkin Mediated Mitophagy; Cargo recognition for clathrin-mediated endocytosis; Ubiquitin-dependent degradation of Cyclin D1; Metalloprotease DUBs; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; M/G1 Transition; Negative regulation of MET activity; L13a-mediated translational silencing of Ceruloplasmin expression; Downregulation of ERBB2:ERBB3 signaling; activated TAK1 mediates p38 MAPK activation; Regulation of RUNX2 expression and activity; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Regulation of DNA replication; Glycogen synthesis; Dectin-1 mediated noncanonical NF-kB signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Orc1 removal from chromatin; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Regulation of TNFR1 signaling; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; Fanconi Anemia Pathway; HDR through Homologous Recombination (HRR); Iron uptake and transport; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Signalling by NGF; Downregulation of TGF-beta receptor signaling" Ribosome 0 High P55096 ATP-binding cassette sub-family D member 3 OS=Mus musculus OX=10090 GN=Abcd3 PE=1 SV=2 0 41.69 23 10 17 10 659 75.4 9.26 1 8 7 1 8 8 4795082.953 13865556 19558339.69 7 10 9 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf06472" 19299 ENSMUSG00000028127.10 Abcd3 3 ABC transporters in lipid homeostasis ABC transporters; Peroxisome 0 High Q9D051 "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Pdhb PE=1 SV=1" 0 36.821 46 10 17 10 359 38.9 6.87 6 6 3 7 7 3 16047400.89 12466361.3 12773914.91 8 8 7 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity "Pf02779, Pf02780" 68263 ENSMUSG00000021748.8 Pdhb 14 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 0 High P15864 Histone H1.2 OS=Mus musculus OX=10090 GN=H1-2 PE=1 SV=2 0 23.588 32 7 17 1 212 21.3 11 4 4 6 5 4 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 50708 ENSMUSG00000036181.2 Hist1h1c 13 0 High Q8R5L1 "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Mus musculus OX=10090 GN=C1qbp PE=1 SV=1" 0 42.061 42 6 17 6 279 31 4.87 2 5 5 2 7 8 11097947.57 19679427.91 20974803.31 6 6 6 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen protein binding;RNA binding Pf02330 12261 ENSMUSG00000018446.8 C1qbp 11 Intrinsic Pathway of Fibrin Clot Formation Herpes simplex infection 0 High Q922U2 "Keratin, type II cytoskeletal 5 OS=Mus musculus OX=10090 GN=Krt5 PE=1 SV=1" 0 24.495 14 9 17 3 580 61.7 7.75 7 6 1 10 6 1 51886565.75 27870645.94 43912426 3 3 2 metabolic process cytoplasm;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf03961, Pf04111, Pf05957" 110308 ENSMUSG00000061527.6 Krt5 15 Type I hemidesmosome assembly; Formation of the cornified envelope 1 High A0A0B4J1G0 Low affinity immunoglobulin gamma Fc region receptor IV OS=Mus musculus OX=10090 GN=Fcgr4 PE=1 SV=1 0 15.086 23 6 17 6 249 28.4 8.09 3 4 6 3 6 8 4295738.148 19902557.38 30185511.88 6 6 6 regulation of biological process;response to stimulus cell surface;membrane protein binding;receptor activity;signal transducer activity "Pf00047, Pf07679, Pf07686, Pf13895, Pf13927" 246256 ENSMUSG00000059089.4 Fcgr4 1 Role of phospholipids in phagocytosis; Post-translational modification: synthesis of GPI-anchored proteins; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR activation Staphylococcus aureus infection; Tuberculosis; Osteoclast differentiation; Phagosome; Natural killer cell mediated cytotoxicity; Systemic lupus erythematosus; Leishmaniasis 0 High Q8BFU2 Histone H2A type 3 OS=Mus musculus OX=10090 GN=H2aw PE=1 SV=3 0 19.346 38 5 17 1 130 14.1 11.05 4 3 5 6 6 5 20569760.3 26171984.5 68826055.75 5 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 319162 ENSMUSG00000078851.4 Hist3h2a 11 RMTs methylate histone arginines; Meiotic Recombination; Mus musculus biological processes; Ub-specific processing proteases; NoRC negatively regulates rRNA expression; UCH proteinases; Metalloprotease DUBs; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus 4 High P62245 40S ribosomal protein S15a OS=Mus musculus OX=10090 GN=Rps15a PE=1 SV=2 0 18.141 52 6 17 6 130 14.8 10.13 5 4 3 6 6 5 7792310 18431229.5 25392281.75 6 5 5 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00410 267019 ENSMUSG00000008683.16 Rps15a 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P38060 "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Mus musculus OX=10090 GN=Hmgcl PE=1 SV=2" 0 32.769 27 6 16 6 325 34.2 8.41 4 4 5 5 4 7 10269425.88 16127634.75 18662501.38 6 5 5 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding Pf00682 15356 ENSMUSG00000028672.13 Hmgcl 4 Synthesis of Ketone Bodies "Valine, leucine and isoleucine degradation; Metabolic pathways; Butanoate metabolism; Synthesis and degradation of ketone bodies; Peroxisome" 0 High Q8BPN8 DmX-like protein 2 OS=Mus musculus OX=10090 GN=Dmxl2 PE=1 SV=3 0 47.593 6 12 16 11 3032 338 6.42 7 9 7 9 168252.5625 11719412.69 10153482.25 1 10 9 cell organization and biogenesis;cellular homeostasis membrane protein binding "Pf00400, Pf12234" 235380 ENSMUSG00000041268.17 Dmxl2 9 1 High Q07797 Galectin-3-binding protein OS=Mus musculus OX=10090 GN=Lgals3bp PE=1 SV=1 0 47.241 22 8 16 8 577 64.5 5.14 2 5 7 2 7 7 1298786.688 7606309.625 13557908.69 3 6 7 transport extracellular;membrane protein binding;receptor activity "Pf00530, Pf07707" 19039 ENSMUSG00000033880.11 Lgals3bp 11 Platelet degranulation 0 High Q64444 Carbonic anhydrase 4 OS=Mus musculus OX=10090 GN=Ca4 PE=1 SV=1 0 23.972 23 5 16 5 305 34.3 8.21 3 4 4 3 8 5 4872969 11168955.41 12826260.81 4 5 4 metabolic process;transport cell surface;endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding Pf00194 12351 ENSMUSG00000000805.18 Car4 11 Erythrocytes take up carbon dioxide and release oxygen; Reversible hydration of carbon dioxide; Erythrocytes take up oxygen and release carbon dioxide Nitrogen metabolism; Proximal tubule bicarbonate reclamation 0 High Q99K67 "Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Mus musculus OX=10090 GN=Aass PE=1 SV=1" 0 31.984 17 10 16 10 926 102.9 6.87 1 7 6 1 8 7 1979476.055 8880503.344 11983403.5 7 8 10 metabolic process mitochondrion catalytic activity "Pf01262, Pf03435, Pf05222" 30956 ENSMUSG00000029695.13 Aass 6 Lysine catabolism Metabolic pathways; Lysine degradation 0 High Q60932 Voltage-dependent anion-selective channel protein 1 OS=Mus musculus OX=10090 GN=Vdac1 PE=1 SV=3 0 33.328 46 10 16 10 296 32.3 8.43 4 6 4 5 6 5 5872835.48 25761866.5 13122911.25 7 7 8 cell communication;cell death;cell differentiation;defense response;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus nucleotide binding;protein binding;transporter activity Pf01459 22333 ENSMUSG00000020402.11 Vdac1 11 Pink/Parkin Mediated Mitophagy NOD-like receptor signaling pathway; HTLV-I infection; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway; Influenza A 0 High P62242 40S ribosomal protein S8 OS=Mus musculus OX=10090 GN=Rps8 PE=1 SV=2 0 31.513 43 7 16 7 208 24.2 10.32 2 4 6 2 7 7 5946612.5 17361755.56 26042790 7 7 7 metabolic process cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf01201 20116; 100040298 ENSMUSG00000047675.15 Rps8; Gm15501 4; 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High E9Q3W1 Casein kinase I isoform alpha OS=Mus musculus OX=10090 GN=Csnk1a1 PE=1 SV=1 0 23.692 21 7 16 7 365 41.9 9.6 1 4 6 2 7 7 1806907.781 6741751.781 8139313.563 5 7 6 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714" 93687 ENSMUSG00000024576.14 Csnk1a1 18 0 High P98086 Complement C1q subcomponent subunit A OS=Mus musculus OX=10090 GN=C1qa PE=1 SV=2 0 19.336 30 6 16 6 245 26 9.11 3 3 6 4 4 8 29323806.24 40191150.69 61669961.5 5 5 6 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00229, Pf00386" 12259 ENSMUSG00000036887.5 C1qa 4 Regulation of Complement cascade; Classical antibody-mediated complement activation Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Prion diseases; Systemic lupus erythematosus 0 High P47963 60S ribosomal protein L13 OS=Mus musculus OX=10090 GN=Rpl13 PE=1 SV=3 0 24.334 34 7 16 7 211 24.3 11.55 1 5 4 1 9 6 8525286.281 29287367.03 33959569.5 7 8 6 metabolic process membrane;nucleus;ribosome RNA binding;structural molecule activity Pf01294 270106 ENSMUSG00000000740.12 Rpl13 8 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q921R2 40S ribosomal protein S13 OS=Mus musculus OX=10090 GN=Rps13 PE=1 SV=1 0 18.807 47 7 16 7 140 16.1 10.71 3 5 5 3 6 7 11015206.16 28058464.88 40282083.63 7 6 7 metabolic process;regulation of biological process membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00312, Pf08069" 68052 ENSMUSG00000090862.3 Rps13 7 0 High P00405 Cytochrome c oxidase subunit 2 OS=Mus musculus OX=10090 GN=Mtco2 PE=1 SV=1 0 34.21 33 4 16 4 227 26 4.73 2 4 4 3 6 7 19873570.5 41089707.5 27896144.38 5 4 5 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;transporter activity "Pf00116, Pf02790" 17709; 3338897 ENSMUSG00000064354.1 COX2 MT Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P62806 Histone H4 OS=Mus musculus OX=10090 GN=H4c1 PE=1 SV=2 0 21.239 50 5 16 5 103 11.4 11.36 4 5 1 6 8 2 10046549.5 14200033 24612762.25 5 5 5 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00125, Pf02969, Pf15630" 320332; 326619; 319160; 319155; 319158; 319161; 69386; 319157; 319159; 326620; 100041230; 319156; 97122; 102641229 ENSMUSG00000096010.2; ENSMUSG00000091405.2; ENSMUSG00000060981.6; ENSMUSG00000069274.3; ENSMUSG00000061482.6; ENSMUSG00000067455.5; ENSMUSG00000064288.4; ENSMUSG00000060678.4; ENSMUSG00000069306.5; ENSMUSG00000069305.3; ENSMUSG00000069266.5; ENSMUSG00000060093.6; ENSMUSG00000060639.5 Hist4h4; Hist1h4a; Hist1h4k; Hist1h4c; Hist1h4i; Hist1h4n; Hist1h4h; Hist1h4f; Hist1h4j; Hist1h4b; Hist1h4m; Hist1h4d; Hist2h4; LOC100862646; LOC102641229 6; 13; 3 Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HATs acetylate histones; Meiotic Recombination; HDMs demethylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Nonhomologous End-Joining (NHEJ); RMTs methylate histone arginines; NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); DNA Damage/Telomere Stress Induced Senescence; SIRT1 negatively regulates rRNA expression; Condensation of Prophase Chromosomes; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; NoRC negatively regulates rRNA expression; Meiotic Synapsis; G2/M DNA damage checkpoint; PKMTs methylate histone lysines; Mus musculus biological processes; RNA Polymerase I Chain Elongation Alcoholism; Systemic lupus erythematosus; Viral carcinogenesis 0 High P62264 40S ribosomal protein S14 OS=Mus musculus OX=10090 GN=Rps14 PE=1 SV=3 0 33.936 57 4 16 4 151 16.3 10.05 2 4 3 3 8 5 3179960.5 10043637.69 11238214.38 3 4 5 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion;ribosome RNA binding;structural molecule activity;translation regulator activity Pf00411 20044 ENSMUSG00000024608.10 Rps14 18 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High E9Q1Z0 Keratin 90 OS=Mus musculus OX=10090 GN=Krt90 PE=1 SV=1 0 15.97 9 6 16 1 538 58.2 8.25 4 3 3 8 4 4 35776128 26469402 20005246 1 1 1 cell organization and biogenesis;metabolic process catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf06810, Pf09728, Pf12128, Pf13166, Pf13514" 239673 ENSMUSG00000048699.4 4732456N10Rik; Krt90 15 0 High B7ZNL2 Nap1l4 protein OS=Mus musculus OX=10090 GN=Nap1l4 PE=1 SV=1 0 32.336 22 6 16 5 386 43.9 4.68 2 4 4 4 6 6 6860939.828 13268141.31 49824313.25 4 4 5 cell organization and biogenesis cytoplasm;nucleus protein binding;RNA binding Pf00956 17955 ENSMUSG00000059119.9 Nap1l4 7 1 High P62754 40S ribosomal protein S6 OS=Mus musculus OX=10090 GN=Rps6 PE=1 SV=1 0 28.231 32 7 16 7 249 28.7 10.84 2 6 4 2 8 6 6854552.094 23142114.19 27507866.63 5 6 6 cell death;cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01092 667739; 20104; 105244208 ENSMUSG00000028495.14 Rps6-ps4; Rps6; LOC105244208 2; 4 mTOR signaling pathway; Ribosome; Insulin signaling pathway; Proteoglycans in cancer; HIF-1 signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance 0 High P54071 "Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus OX=10090 GN=Idh2 PE=1 SV=3" 0 32.641 27 10 16 9 452 50.9 8.69 3 6 7 3 6 7 3524715.203 7159959.844 7647429.313 7 7 7 metabolic process;regulation of biological process cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00180 269951 ENSMUSG00000030541.16 Idh2 7 Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle) Glutathione metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Peroxisome 0 High P62270 40S ribosomal protein S18 OS=Mus musculus OX=10090 GN=Rps18 PE=1 SV=3 0 19.835 30 6 16 6 152 17.7 10.99 1 3 6 1 6 9 4064727 12909789.81 20835640.44 6 7 7 metabolic process cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00416 20084 ENSMUSG00000008668.14 Rps18 17 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q61171 Peroxiredoxin-2 OS=Mus musculus OX=10090 GN=Prdx2 PE=1 SV=3 0 30.613 29 6 15 6 198 21.8 5.41 2 4 4 2 7 6 3115797.219 9119584.563 13582191.63 4 5 5 Met-loss+Acetyl [N-Term] cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 21672 ENSMUSG00000005161.15 Prdx2 8 Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes 0 High A0A0G2JG59 Nexilin (Fragment) OS=Mus musculus OX=10090 GN=Nexn PE=1 SV=1 0 29.098 23 10 15 10 473 56.6 5.06 3 6 6 3 6 6 3320716.063 7862338.75 13825184.38 5 8 7 protein binding "Pf00047, Pf07679, Pf13895" ENSMUSG00000039103.12 3 0 High Q3U367 4-trimethylaminobutyraldehyde dehydrogenase OS=Mus musculus OX=10090 GN=Aldh9a1 PE=1 SV=1 0 24.354 17 7 15 7 518 55.9 7.46 4 4 6 4 4 7 3096823.031 7287426.75 7430969.25 7 7 5 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding Pf00171 56752 ENSMUSG00000026687.14 Aldh9a1 1 Carnitine synthesis "Histidine metabolism; Pyruvate metabolism; Arginine and proline metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Glycolysis / Gluconeogenesis; beta-Alanine metabolism; Ascorbate and aldarate metabolism; Glycerolipid metabolism" 0 High Q4VAC9 Pleckstrin homology domain-containing family G member 3 OS=Mus musculus OX=10090 GN=Plekhg3 PE=1 SV=2 0 39.707 11 9 15 9 1341 148.4 5.68 1 8 5 1 9 5 2577375.406 13348293.28 14732764.88 4 7 8 regulation of biological process "Pf00169, Pf00621" 263406 ENSMUSG00000052609.9 Plekhg3 12 0 High P47962 60S ribosomal protein L5 OS=Mus musculus OX=10090 GN=Rpl5 PE=1 SV=3 0 25.704 17 5 15 5 297 34.4 9.77 2 4 5 2 7 6 3454298.219 9771208.813 18124383.5 5 4 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00861, Pf14204" 100503670 ENSMUSG00000058558.12 Rpl5 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9Z1T1 AP-3 complex subunit beta-1 OS=Mus musculus OX=10090 GN=Ap3b1 PE=1 SV=2 0 26.718 11 11 15 11 1105 122.7 5.66 1 6 7 1 7 7 1619302.266 8051658.094 10968023.63 5 9 10 cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;transport Golgi;membrane protein binding "Pf01602, Pf13646, Pf14796" 11774 ENSMUSG00000021686.4 Ap3b1 13 Golgi Associated Vesicle Biogenesis Lysosome 0 High Q8CGC7 Bifunctional glutamate/proline--tRNA ligase OS=Mus musculus OX=10090 GN=Eprs1 PE=1 SV=4 0 35.579 10 12 15 12 1512 170 7.66 7 8 7 8 5812573.406 6921631.375 8 9 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497" 107508 ENSMUSG00000026615.14 Eprs 1 Metabolic pathways; Aminoacyl-tRNA biosynthesis; Porphyrin and chlorophyll metabolism 0 High Q9CZX8 40S ribosomal protein S19 OS=Mus musculus OX=10090 GN=Rps19 PE=1 SV=3 0 14.782 27 5 15 5 145 16.1 10.4 1 4 5 2 7 6 6867413.328 18706165.88 22152065.75 5 5 5 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01090 20085 ENSMUSG00000040952.16 Rps19 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q3TU25 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus OX=10090 GN=Ddx17 PE=1 SV=1 0 25.433 18 7 15 3 418 47.4 8.02 1 5 5 1 7 7 1595888.781 2086450 3 3 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 67040 Ddx17 15 0 High Q8C605 ATP-dependent 6-phosphofructokinase OS=Mus musculus OX=10090 GN=Pfkp PE=1 SV=1 0 31.422 17 9 15 6 784 85.5 6.89 2 6 6 2 6 7 1560705.406 3880149.625 5492500.75 5 6 5 cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 56421 ENSMUSG00000021196.13 Pfkp 13 RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Thyroid hormone signaling pathway; Pentose phosphate pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer 0 High O55143 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Mus musculus OX=10090 GN=Atp2a2 PE=1 SV=2 0 36.927 13 12 15 12 1044 114.8 5.34 6 8 6 9 1729177.594 6492807 16172293.13 4 8 9 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 11938 ENSMUSG00000029467.15 Atp2a2 5 Ion transport by P-type ATPases; Ion homeostasis; Reduction of cytosolic Ca++ levels Hypertrophic cardiomyopathy (HCM); Pancreatic secretion; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Thyroid hormone signaling pathway; cGMP-PKG signaling pathway; Calcium signaling pathway; Alzheimer's disease; Cardiac muscle contraction; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes 0 High Q3UYG1 Coiled-coil domain-containing protein 160 OS=Mus musculus OX=10090 GN=Ccdc160 PE=2 SV=1 0 22.717 28 8 15 8 323 37.4 9.32 1 7 5 1 9 5 973585.6094 12743775.06 11047711 4 8 7 434778 ENSMUSG00000073207.1 Ccdc160 X 0 High P52480 Pyruvate kinase PKM OS=Mus musculus OX=10090 GN=Pkm PE=1 SV=4 0 30.445 27 9 15 9 531 57.8 7.47 3 2 9 3 2 10 3328740.547 4930426.813 8889268.25 5 5 6 Met-loss [N-Term] cell death;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00224, Pf02887" 18746 ENSMUSG00000032294.17 Pkm 9 Neutrophil degranulation; Glycolysis Pyruvate metabolism; Type II diabetes mellitus; Metabolic pathways; Biosynthesis of amino acids; Purine metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway; Viral carcinogenesis 0 High P61358 60S ribosomal protein L27 OS=Mus musculus OX=10090 GN=Rpl27 PE=1 SV=2 0 17.583 43 6 15 6 136 15.8 10.56 2 3 6 3 5 7 8402349.063 20014240.31 30005781.5 6 6 6 metabolic process membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00467, Pf01777" 19942; 108167922 ENSMUSG00000063316.13; ENSMUSG00000073640.2 Rpl27; LOC108167922 11; 18 Ribosome 0 High A0A0R4J0B6 Broad substrate-specificity ATP-binding cassette transporter ABCG2 OS=Mus musculus OX=10090 GN=Abcg2 PE=1 SV=1 0 26.845 13 7 15 7 657 73 8.54 2 5 7 3 5 7 1724691.25 10093175.94 14355474.5 4 6 6 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf01061, Pf12698, Pf13304, Pf13476" 26357 ENSMUSG00000029802.13 Abcg2 6 Iron uptake and transport ABC transporters; Antifolate resistance; Bile secretion 0 High P62830 60S ribosomal protein L23 OS=Mus musculus OX=10090 GN=Rpl23 PE=1 SV=1 0 24.051 39 5 15 5 140 14.9 10.51 3 4 4 4 6 5 4009710.156 10187126.94 17651543 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00238 65019; 100044627; 100862455 ENSMUSG00000071415.6 Rpl23; LOC100044627; LOC100862455 11; 17 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P48771 "Cytochrome c oxidase subunit 7A2, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a2 PE=1 SV=2" 0 12.543 28 2 15 2 83 9.3 10.27 2 2 2 4 7 4 11413366.25 30678131.5 15804955 3 3 3 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02238 12866 ENSMUSG00000032330.7 Cox7a2 9 Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q8VEM8 "Phosphate carrier protein, mitochondrial OS=Mus musculus OX=10090 GN=Slc25a3 PE=1 SV=1" 0 22.359 28 8 15 8 357 39.6 9.26 8 4 9 6 5790052.219 17802450.5 16085796.06 6 7 6 transport membrane;mitochondrion protein binding;transporter activity Pf00153 18674 ENSMUSG00000061904.12 Slc25a3 10 0 High O88844 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Mus musculus OX=10090 GN=Idh1 PE=1 SV=2 0 34.243 28 11 15 10 414 46.6 7.17 2 5 8 2 5 8 1807911.063 9175205.344 10397678.13 4 9 7 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00180, Pf01960" 15926 ENSMUSG00000025950.16 Idh1 1 Neutrophil degranulation; NADPH regeneration Glutathione metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Peroxisome 1 High P85094 Isochorismatase domain-containing protein 2A OS=Mus musculus OX=10090 GN=Isoc2a PE=1 SV=1 0 49.65 59 6 15 6 206 22.4 8.02 1 5 6 1 6 8 1457196.875 4388371.469 8529760.25 3 5 6 metabolic process;regulation of biological process cytoplasm;mitochondrion;nucleus catalytic activity Pf00857 664994 ENSMUSG00000086784.2 Isoc2a 7 0 High P62889 60S ribosomal protein L30 OS=Mus musculus OX=10090 GN=Rpl30 PE=1 SV=2 0 27.869 59 5 15 5 115 12.8 9.63 2 4 4 2 6 7 3280982.719 13282180.38 13803083.5 3 5 4 defense response;metabolic process;response to stimulus membrane;nucleus;ribosome RNA binding;structural molecule activity Pf01248 19946; 667779; 666899 ENSMUSG00000058600.13 Rpl30; Rpl30-ps8; Gm12191 15; 12; 11 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P47754 F-actin-capping protein subunit alpha-2 OS=Mus musculus OX=10090 GN=Capza2 PE=1 SV=3 0 27.419 37 8 15 7 286 32.9 5.85 4 6 8 7 16296655.36 16363933.88 17205651.94 5 6 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cytoskeleton;membrane protein binding Pf01267 12343 ENSMUSG00000015733.13 Capza2 6 Advanced glycosylation endproduct receptor signaling; COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; Factors involved in megakaryocyte development and platelet production; HSP90 chaperone cycle for steroid hormone receptors (SHR) Endocytosis 1 High P80315 T-complex protein 1 subunit delta OS=Mus musculus OX=10090 GN=Cct4 PE=1 SV=3 0 28.204 24 10 14 10 539 58 8.02 2 4 8 2 4 8 2454642.008 8589356.969 13917057.56 7 9 8 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 12464 ENSMUSG00000007739.10 Cct4 11 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High Q91VD9 "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs1 PE=1 SV=2" 0 37.781 19 11 14 11 727 79.7 5.72 2 7 5 2 7 5 2739703.203 15765987.81 12053547.19 6 10 6 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding "Pf00111, Pf00384, Pf09326, Pf10588, Pf13510" 227197 ENSMUSG00000025968.16 Ndufs1 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P28653 Biglycan OS=Mus musculus OX=10090 GN=Bgn PE=1 SV=1 0 24.852 25 7 14 6 369 41.6 7.27 2 5 5 2 6 6 2284237.313 5473117.438 12251012.25 4 6 5 metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular;membrane enzyme regulator activity;protein binding "Pf01462, Pf12799, Pf13855, Pf14580" 12111 ENSMUSG00000031375.17 Bgn X A tetrasaccharide linker sequence is required for GAG synthesis; ECM proteoglycans; CS/DS degradation; Dermatan sulfate biosynthesis; Chondroitin sulfate biosynthesis 1 High F8WIE5 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus OX=10090 GN=Hectd1 PE=1 SV=1 0 21.384 4 11 14 11 2610 289 5.36 5 5 4 5 5 4 3171401.969 4971351.344 9537098.875 8 9 9 cell differentiation;metabolic process;regulation of biological process cytoplasm catalytic activity;metal ion binding;protein binding "Pf00023, Pf00632, Pf00754, Pf06701, Pf07738, Pf12796, Pf13606, Pf13637, Pf13857" 207304 ENSMUSG00000035247.16 Hectd1 12 0 High P00329 Alcohol dehydrogenase 1 OS=Mus musculus OX=10090 GN=Adh1 PE=1 SV=2 0 30.763 32 7 14 7 375 39.7 8.1 1 6 4 1 6 7 2120335.469 7498752.25 14266682.5 4 5 5 metabolic process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00107, Pf08240" 11522 ENSMUSG00000074207.10 Adh1 3 RA biosynthesis pathway; Ethanol oxidation; Abacavir metabolism Drug metabolism - cytochrome P450; Retinol metabolism; Metabolic pathways; Fatty acid degradation; Glycolysis / Gluconeogenesis; Chemical carcinogenesis; Tyrosine metabolism; Metabolism of xenobiotics by cytochrome P450 0 High P28271 Cytoplasmic aconitate hydratase OS=Mus musculus OX=10090 GN=Aco1 PE=1 SV=3 0 36.975 14 9 14 9 889 98.1 7.5 4 8 4 10 4045850.516 5602515.156 9646662.625 6 7 7 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;Golgi;mitochondrion catalytic activity;metal ion binding;RNA binding "Pf00330, Pf00694" 11428 ENSMUSG00000028405.9 Aco1 4 Iron uptake and transport Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High Q8BP67 60S ribosomal protein L24 OS=Mus musculus OX=10090 GN=Rpl24 PE=1 SV=2 0 20.648 41 7 14 7 157 17.8 11.25 2 5 3 2 7 5 10230837.25 24803376 34531716.63 7 7 7 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01246 68193 ENSMUSG00000098274.7 Rpl24 16 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A0A1L1SRG5 Alpha-crystallin B chain (Fragment) OS=Mus musculus OX=10090 GN=Cryab PE=1 SV=1 0 12.205 38 5 14 5 130 15.4 6.61 3 5 3 4 6 4 2864358.203 7865844.125 5984452.625 5 5 3 Acetyl [N-Term] structural molecule activity "Pf00011, Pf00525" ENSMUSG00000032060.10 9 0 High P14094 Sodium/potassium-transporting ATPase subunit beta-1 OS=Mus musculus OX=10090 GN=Atp1b1 PE=1 SV=1 0 17.884 21 5 14 5 304 35.2 8.65 3 5 3 3 7 4 8030935.875 16379528.5 21755683.25 4 4 4 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;transporter activity Pf00287 11931 ENSMUSG00000026576.12 Atp1b1 1 Ion transport by P-type ATPases; Ion homeostasis; Basigin interactions Pancreatic secretion; Carbohydrate digestion and absorption; Mineral absorption; Protein digestion and absorption; Endocrine and other factor-regulated calcium reabsorption; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Proximal tubule bicarbonate reclamation; cGMP-PKG signaling pathway; Bile secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Gastric acid secretion; Insulin secretion; Adrenergic signaling in cardiomyocytes; Aldosterone-regulated sodium reabsorption 0 High Q8C8R3 Ankyrin-2 OS=Mus musculus OX=10090 GN=Ank2 PE=1 SV=2 0 31.176 2 8 14 2 3898 426 5.17 1 7 5 1 7 6 969129.5625 1794835.75 1 1 cell communication;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;endosome;membrane;mitochondrion;vacuole protein binding "Pf00023, Pf00531, Pf00791, Pf03326, Pf12796, Pf13606, Pf13637, Pf13857" 109676 Ank2 3 COPI-mediated anterograde transport; Interaction between L1 and Ankyrins 0 High E9Q0F0 Keratin 78 OS=Mus musculus OX=10090 GN=Krt78 PE=1 SV=1 0 11.595 1 1 14 1 1068 112.2 7.97 1 1 1 5 6 3 25627378.06 12615614.81 14279411.13 2 2 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoskeleton;Golgi;membrane catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf01576, Pf02050, Pf02321, Pf02403, Pf03280, Pf03938, Pf04111, Pf04156, Pf04740, Pf04977, Pf05008, Pf05103, Pf05335, Pf05483, Pf05557, Pf05622, Pf05642, Pf05667, Pf05911, Pf06013, Pf06133, Pf06160, Pf06810, Pf07321, Pf07926, Pf08614, Pf09606, Pf09726, Pf09731, Pf09755, Pf11559, Pf11932, Pf12128, Pf12325, Pf12329, Pf12795, Pf13514, Pf13851, Pf14362, Pf15070, Pf15397" 332131 ENSMUSG00000050463.8 Krt78 15 Formation of the cornified envelope 0 High Q9CR57 60S ribosomal protein L14 OS=Mus musculus OX=10090 GN=Rpl14 PE=1 SV=3 0 21.013 22 4 14 4 217 23.5 11.02 3 4 3 4 6 4 8578238.938 16260871.38 26489382.25 4 4 4 metabolic process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01929 67115 ENSMUSG00000025794.9 Rpl14 9 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P56389 Cytidine deaminase OS=Mus musculus OX=10090 GN=Cda PE=1 SV=2 0 29.054 65 6 14 6 146 16.1 5.58 2 4 4 3 7 4 12030474.25 17770767.75 14845601 3 4 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytosol catalytic activity;metal ion binding;protein binding "Pf00383, Pf08211, Pf14421" 72269 ENSMUSG00000028755.3 Cda 4 Neutrophil degranulation; Pyrimidine salvage Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High O70318 Band 4.1-like protein 2 OS=Mus musculus OX=10090 GN=Epb41l2 PE=1 SV=2 0 23.28 10 9 14 5 988 109.9 5.43 1 6 6 1 6 7 208377.9063 3117581.313 5494742.813 1 4 5 cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" 13822 ENSMUSG00000019978.16 Epb4.1l2; Epb41l2 10 Neurexins and neuroligins Tight junction 0 High Q9WU79 "Proline dehydrogenase 1, mitochondrial OS=Mus musculus OX=10090 GN=Prodh PE=1 SV=2" 0 34.843 21 8 14 8 599 68 8.24 4 8 5 9 1033731.961 6332867.906 11954118.19 5 6 8 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding Pf01619 19125 ENSMUSG00000003526.11; ENSMUSG00000111321.1 Prodh 16; CHR_MG3833_MG4220_PATCH Proline catabolism Arginine and proline metabolism; Metabolic pathways 0 High P67871 Casein kinase II subunit beta OS=Mus musculus OX=10090 GN=Csnk2b PE=1 SV=1 0 29.592 26 5 14 5 215 24.9 5.55 2 3 5 2 3 9 2323966.063 5010909.438 8773634.313 3 4 5 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;enzyme regulator activity;metal ion binding;protein binding Pf01214 13001 ENSMUSG00000024387.13 Csnk2b 17 WNT mediated activation of DVL; Regulation of TP53 Activity through Phosphorylation; Neutrophil degranulation; Synthesis of PC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Condensation of Prometaphase Chromosomes; Receptor Mediated Mitophagy; Regulation of PTEN stability and activity; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Herpes simplex infection; Wnt signaling pathway; Epstein-Barr virus infection; Adherens junction; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Tight junction; Measles 0 High Q9QYB8 Beta-adducin OS=Mus musculus OX=10090 GN=Add2 PE=1 SV=4 0 25.844 12 7 14 6 725 80.6 6.21 2 5 5 2 6 6 2452054.375 12759463.81 9450835.875 3 4 5 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00596, Pf03344" 11519 ENSMUSG00000030000.10 Add2 6 Miscellaneous transport and binding events 0 High P51655 Glypican-4 OS=Mus musculus OX=10090 GN=Gpc4 PE=1 SV=2 0 33.618 22 8 14 7 557 62.5 6.33 3 5 5 4 5 5 5280314.219 11080572.88 11594116.06 5 6 7 extracellular;membrane;nucleus;organelle lumen protein binding Pf01153 14735 ENSMUSG00000031119.4 Gpc4 X HS-GAG degradation; A tetrasaccharide linker sequence is required for GAG synthesis; Signaling by GPCR; Retinoid metabolism and transport; HS-GAG biosynthesis Wnt signaling pathway 1 High Q9CXW4 60S ribosomal protein L11 OS=Mus musculus OX=10090 GN=Rpl11 PE=1 SV=4 0 15.326 20 3 14 3 178 20.2 9.6 3 3 3 4 6 4 5791197.625 15041670.75 19901249 3 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00281, Pf00673" 67025 ENSMUSG00000059291.15 Rpl11 4 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8C0T5 Signal-induced proliferation-associated 1-like protein 1 OS=Mus musculus OX=10090 GN=Sipa1l1 PE=1 SV=2 0 21.243 3 5 14 5 1782 196.9 8.13 5 4 8 6 84533.07813 21912796.78 26225314.44 1 6 5 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane enzyme regulator activity;protein binding "Pf00595, Pf02145, Pf11881" 217692 ENSMUSG00000042700.15 Sipa1l1 12 Rap1 signaling pathway 0 High A0A1L1SQA8 40S ribosomal protein S25 OS=Mus musculus OX=10090 GN=Rps25 PE=1 SV=1 0 12.049 32 4 13 4 93 10.3 9.99 3 2 3 4 3 6 8435458.156 15503915.75 15927063.13 4 4 4 Pf03297 ENSMUSG00000009927.9 9 0 High Q61753 D-3-phosphoglycerate dehydrogenase OS=Mus musculus OX=10090 GN=Phgdh PE=1 SV=3 0 27.451 18 8 13 8 533 56.5 6.54 5 1 6 6 1 6 8042085.25 12978009.69 24958746.81 7 7 6 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process catalytic activity;nucleotide binding "Pf00389, Pf02826" 236539 ENSMUSG00000053398.11 Phgdh 3 Serine biosynthesis "Metabolic pathways; Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Carbon metabolism" 0 High Q61847 Meprin A subunit beta OS=Mus musculus OX=10090 GN=Mep1b PE=1 SV=2 0 27.37 13 7 13 7 704 79.5 5.95 1 6 6 1 6 6 1557042.469 8003283.5 9341392.375 4 7 6 defense response;metabolic process;response to stimulus;transport extracellular;membrane catalytic activity;metal ion binding;protein binding "Pf00629, Pf00917, Pf01400, Pf07974" 17288 ENSMUSG00000024313.7 Mep1b 18 Protein digestion and absorption 0 High A0A1D5RLW5 60S ribosomal protein L18a OS=Mus musculus OX=10090 GN=Rpl18a PE=1 SV=1 0 20.202 42 6 13 6 147 17.4 10.89 2 4 4 3 4 6 6144886.063 14902137.06 20596685.19 5 6 5 metabolic process ribosome structural molecule activity Pf01775 ENSMUSG00000045128.9 8 0 High Q9JJI8 60S ribosomal protein L38 OS=Mus musculus OX=10090 GN=Rpl38 PE=1 SV=3 0 18.507 36 4 13 4 70 8.2 10.1 2 3 2 4 6 3 5338589.844 9389911 11553645.31 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process ribosome RNA binding;structural molecule activity Pf01781 67671; 625646; 664868 ENSMUSG00000057322.12 Rpl38; Rpl38-ps1; Rpl38-ps2 11; 4; 6 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P67984 60S ribosomal protein L22 OS=Mus musculus OX=10090 GN=Rpl22 PE=1 SV=2 0 26.745 44 4 13 4 128 14.8 9.19 4 3 3 6 3 4 7232554.375 16002779.25 15843103 4 4 3 cell differentiation;metabolic process cytoplasm;nucleus;ribosome RNA binding;structural molecule activity Pf01776 19934; 100047372; 102642602 ENSMUSG00000028936.15 Rpl22; LOC100047372; LOC100504863; LOC102642602 4; 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62315 Small nuclear ribonucleoprotein Sm D1 OS=Mus musculus OX=10090 GN=Snrpd1 PE=1 SV=1 0 17.38 55 4 13 4 119 13.3 11.56 2 3 4 2 5 6 1007826.344 12048662.69 13772224.25 3 4 4 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex RNA binding Pf01423 20641 ENSMUSG00000002477.4 Snrpd1 18 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly Spliceosome; Systemic lupus erythematosus 0 High P47738 "Aldehyde dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Aldh2 PE=1 SV=1" 0 30.171 26 10 13 10 519 56.5 7.62 4 5 4 4 5 4 8916231.813 36175828 31478740.75 7 8 7 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding Pf00171 11669 ENSMUSG00000029455.14 Aldh2 5 Metabolism of serotonin; Ethanol oxidation "Histidine metabolism; Pyruvate metabolism; Arginine and proline metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Glycolysis / Gluconeogenesis; beta-Alanine metabolism; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pentose and glucuronate interconversions" 0 High P80314 T-complex protein 1 subunit beta OS=Mus musculus OX=10090 GN=Cct2 PE=1 SV=4 0 27.339 21 8 13 8 535 57.4 6.4 2 4 6 2 4 7 2750170.328 7550884.156 10199292.81 7 7 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol nucleotide binding;protein binding Pf00118 12461 ENSMUSG00000034024.8 Cct2 10 Neutrophil degranulation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 Medium G3UYC6 Synaptotagmin-like protein 4 (Fragment) OS=Mus musculus OX=10090 GN=Sytl4 PE=1 SV=8 0.041 1.485 5 1 13 1 185 21.6 9.07 1 1 1 2 6 5 80852288 51674993 122874187.7 1 1 1 regulation of biological process;transport protein binding Pf02318 ENSMUSG00000031255.14 X 0 High P11862 Growth arrest-specific protein 2 OS=Mus musculus OX=10090 GN=Gas2 PE=1 SV=1 0 31.871 40 9 13 9 314 34.9 8.57 4 8 4 9 1180452.026 6287219.625 12884462.88 3 7 7 cell death;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding "Pf00307, Pf02187" 14453 ENSMUSG00000030498.15 Gas2 7 Caspase-mediated cleavage of cytoskeletal proteins 0 High P61164 Alpha-centractin OS=Mus musculus OX=10090 GN=Actr1a PE=1 SV=1 0 44.75 34 9 13 4 376 42.6 6.64 1 4 7 1 4 8 3309890.438 6817865.125 9740339 3 3 2 cytoplasm;cytoskeleton nucleotide binding Pf00022 54130 ENSMUSG00000025228.4 Actr1a 19 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR); COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation 0 High P14206 40S ribosomal protein SA OS=Mus musculus OX=10090 GN=Rpsa PE=1 SV=4 0 33.927 31 6 13 6 295 32.8 4.87 1 4 6 1 4 8 2371627.875 7227587 9597481.25 4 4 4 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;receptor activity;RNA binding;structural molecule activity Pf00318 16785; 100045332; 102642689 ENSMUSG00000032518.6 Rpsa; LOC100045332; LOC100505031; LOC102642689 9; 19 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High O35286 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Mus musculus OX=10090 GN=Dhx15 PE=1 SV=2 0 30.999 17 11 13 11 795 90.9 7.46 8 4 9 4 979686.5703 9130279.5 12828389.63 4 8 9 metabolic process;response to stimulus cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 13204 ENSMUSG00000029169.11 Dhx15 5 mRNA Splicing - Major Pathway Spliceosome 0 High P97742 "Carnitine O-palmitoyltransferase 1, liver isoform OS=Mus musculus OX=10090 GN=Cpt1a PE=1 SV=4" 0 23.861 15 8 13 7 773 88.2 8.62 1 5 6 1 5 7 1199196.359 8867867.125 13065633.5 4 7 6 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity;protein binding Pf00755 12894 ENSMUSG00000024900.4 Cpt1a 19 Circadian Clock; Mus musculus biological processes; Signaling by Retinoic Acid; Rora activates gene expression; Import of palmitoyl-CoA into the mitochondrial matrix PPAR signaling pathway; Fatty acid metabolism; Fatty acid degradation; Insulin resistance; Adipocytokine signaling pathway; AMPK signaling pathway; Glucagon signaling pathway 1 High P11679 "Keratin, type II cytoskeletal 8 OS=Mus musculus OX=10090 GN=Krt8 PE=1 SV=4" 0 20.44 16 7 13 5 490 54.5 5.82 3 5 5 3 5 5 1477083.281 3384693.406 4101884.125 5 5 5 cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf09726, Pf10186, Pf12128, Pf13166, Pf13514, Pf15003" 16691 ENSMUSG00000049382.9 Krt8 15 Formation of the cornified envelope 0 High H7BWY3 "Alanine--glyoxylate aminotransferase 2, mitochondrial OS=Mus musculus OX=10090 GN=Agxt2 PE=1 SV=1" 0 38.468 24 8 13 8 541 60.1 7.9 1 4 7 1 4 8 904530.3594 4916466.781 8602314.688 3 6 6 metabolic process;regulation of biological process mitochondrion catalytic activity;protein binding "Pf00155, Pf00202" 268782 ENSMUSG00000089678.8 Agxt2 15 0 High P63037 DnaJ homolog subfamily A member 1 OS=Mus musculus OX=10090 GN=Dnaja1 PE=1 SV=1 0 32.697 32 7 13 7 397 44.8 7.08 2 4 5 2 4 7 2748245.059 5758201.664 11369347.33 4 6 5 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 15502 ENSMUSG00000028410.13 Dnaja1 4 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High Q9CZN7 "Serine hydroxymethyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Shmt2 PE=1 SV=1" 0 36.763 28 11 13 11 504 55.7 8.47 3 4 6 3 4 6 5132856.125 10479735.31 15958125.69 9 9 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00464 108037 ENSMUSG00000025403.5 Shmt2 10 Metabolism of folate and pterines "Metabolic pathways; Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Antifolate resistance; Carbon metabolism; One carbon pool by folate; Glyoxylate and dicarboxylate metabolism" 0 High Q9QXD6 "Fructose-1,6-bisphosphatase 1 OS=Mus musculus OX=10090 GN=Fbp1 PE=1 SV=3" 0 28.479 36 8 13 8 338 36.9 6.57 2 5 5 2 6 5 2243659.063 10801680.06 13611006.02 4 6 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00316, Pf00459" 14121 ENSMUSG00000069805.10 Fbp1 13 Gluconeogenesis Insulin signaling pathway; Metabolic pathways; Glycolysis / Gluconeogenesis; Pentose phosphate pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Glucagon signaling pathway 0 High Q3UQN2 F-BAR domain only protein 2 OS=Mus musculus OX=10090 GN=Fcho2 PE=1 SV=1 0 29.07 11 6 13 6 809 88.7 6.89 1 5 4 1 6 6 1008135.734 4751511.75 4963115.484 4 5 4 cell organization and biogenesis;transport membrane protein binding "Pf00611, Pf10291" 218503 ENSMUSG00000041685.15 Fcho2 13 Cargo recognition for clathrin-mediated endocytosis 0 High Q9Z2I8 "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Suclg2 PE=1 SV=3" 0 30.969 21 8 13 8 433 46.8 7.02 2 6 4 2 6 5 6537485.594 20461782.31 32943107.75 6 7 5 metabolic process membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00549, Pf01071, Pf08442, Pf13549" 20917 ENSMUSG00000061838.7 Suclg2 6 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Propanoate metabolism; Carbon metabolism 0 High P45591 Cofilin-2 OS=Mus musculus OX=10090 GN=Cfl2 PE=1 SV=1 0 10.981 24 4 13 2 166 18.7 7.88 2 3 4 3 5 5 1832529 3244229.563 2 2 cell organization and biogenesis;cellular homeostasis;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding Pf00241 12632 ENSMUSG00000062929.7 Cfl2 12 Regulation of actin cytoskeleton; Axon guidance; Pertussis; Fc gamma R-mediated phagocytosis 0 High Q542V3 Serine/arginine-rich-splicing factor 4 OS=Mus musculus OX=10090 GN=Srsf4 PE=1 SV=1 0 25.059 13 7 13 5 491 56.2 11.37 7 4 9 4 5052329.328 26748885.25 26007105.75 4 6 5 cell differentiation;metabolic process;regulation of biological process;response to stimulus nucleus RNA binding "Pf00076, Pf13893, Pf14259" 57317 ENSMUSG00000028911.16 Srsf4 4 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 3 High P43024 "Cytochrome c oxidase subunit 6A1, mitochondrial OS=Mus musculus OX=10090 GN=Cox6a1 PE=1 SV=2" 0 18.598 61 4 13 4 111 12.3 9.98 2 4 2 2 7 4 3546015.914 14876441 7995620.125 4 4 4 metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;enzyme regulator activity;transporter activity Pf02046 12861 Cox6a1 5 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P98078 Disabled homolog 2 OS=Mus musculus OX=10090 GN=Dab2 PE=1 SV=2 0 24.772 11 6 13 6 766 82.3 6.1 5 4 7 6 2839606.156 14980279 14696825.13 4 6 5 cell death;cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus protein binding;receptor activity Pf00640 13132 Dab2 15 Endocytosis 0 High P09405 Nucleolin OS=Mus musculus OX=10090 GN=Ncl PE=1 SV=2 0 24.976 12 6 12 6 707 76.7 4.75 3 3 6 3 3 6 6100011.203 18077302.06 10024430.94 5 6 5 regulation of biological process;response to stimulus;transport cell surface;cytoplasm;membrane;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 17975 ENSMUSG00000026234.12 Ncl 1 Major pathway of rRNA processing in the nucleolus and cytosol 0 High P84099 60S ribosomal protein L19 OS=Mus musculus OX=10090 GN=Rpl19 PE=1 SV=1 0 17.797 23 6 12 6 196 23.5 11.47 4 6 1 4 7 1 6271031 13197907.94 15317879.38 5 5 3 metabolic process membrane;ribosome RNA binding;structural molecule activity Pf01280 19921; 100041511 ENSMUSG00000017404.12 Rpl19; Rpl19-ps11 11; 8 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8BGZ7 "Keratin, type II cytoskeletal 75 OS=Mus musculus OX=10090 GN=Krt75 PE=1 SV=1" 0 20.262 11 7 12 1 551 59.7 8.31 6 3 1 8 3 1 738322.9375 519731.25 1 1 cell differentiation;metabolic process;transport catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00012, Pf00038, Pf01496, Pf01576, Pf04111, Pf04156, Pf09728, Pf13166" 109052 ENSMUSG00000022986.5 Krt75 15 Formation of the cornified envelope 0 High A0A2R8VHP3 Predicted pseudogene 5478 OS=Mus musculus OX=10090 GN=Gm5478 PE=1 SV=1 0 13.674 8 5 12 2 535 57.9 6.2 5 2 2 6 2 4 6037094.813 6609394.313 8872061.75 2 2 2 0 High Q9Z329 "Inositol 1,4,5-trisphosphate receptor type 2 OS=Mus musculus OX=10090 GN=Itpr2 PE=1 SV=4" 0 29.814 5 8 12 7 2701 307.3 6.44 2 3 7 2 3 7 279840.625 1662072.469 3319204.375 1 2 4 cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;nucleus metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf01365, Pf02815, Pf08454, Pf08709, Pf12670" 16439 ENSMUSG00000030287.15 Itpr2 6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Effects of PIP2 hydrolysis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Gastrin-CREB signalling pathway via PKC and MAPK; Elevation of cytosolic Ca2+ levels Oxytocin signaling pathway; Cholinergic synapse; Retrograde endocannabinoid signaling; Pancreatic secretion; Dopaminergic synapse; NOD-like receptor signaling pathway; Long-term potentiation; Platelet activation; Thyroid hormone synthesis; Oocyte meiosis; Glutamatergic synapse; Proteoglycans in cancer; Long-term depression; cGMP-PKG signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Gastric acid secretion; Renin secretion; Gap junction; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Serotonergic synapse; Inflammatory mediator regulation of TRP channels; Apoptosis 0 High E0CXB9 Catenin alpha-2 OS=Mus musculus OX=10090 GN=Ctnna2 PE=1 SV=1 0 23.562 9 7 12 1 966 106.7 5.69 4 4 4 4 4 4 891019.75 1423511.25 1937313.125 1 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity Pf01044 12386 ENSMUSG00000063063.12 Ctnna2 6 0 High A0A0A0MQM0 Eukaryotic translation initiation factor 5A (Fragment) OS=Mus musculus OX=10090 GN=Eif5a PE=1 SV=1 0 19.517 37 5 12 5 149 16.3 5 1 4 3 1 5 6 1250887.734 5913127 11419104.5 4 4 4 cell death;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;membrane;nucleus protein binding;RNA binding Pf01287 276770 ENSMUSG00000078812.10 Eif5a 11 0 High Q9EQP2 EH domain-containing protein 4 OS=Mus musculus OX=10090 GN=Ehd4 PE=1 SV=1 0 27.506 19 9 12 7 541 61.4 6.76 3 3 6 3 3 6 1265093.5 4736783.656 9179637 4 5 7 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;membrane metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 98878 ENSMUSG00000027293.13 Ehd4 2 Endocytosis 1 High Q9WVL0 Maleylacetoacetate isomerase OS=Mus musculus OX=10090 GN=Gstz1 PE=1 SV=1 0 31.37 48 7 12 7 216 24.3 7.85 5 5 5 7 2221023.813 9237862.938 16079193.75 4 5 6 metabolic process cytoplasm;mitochondrion catalytic activity;protein binding "Pf00043, Pf02798, Pf13409, Pf13417" 14874 ENSMUSG00000021033.10 Gstz1 12 Phenylalanine and tyrosine catabolism; Glutathione conjugation Metabolic pathways; Tyrosine metabolism 0 High Q8CG76 Aflatoxin B1 aldehyde reductase member 2 OS=Mus musculus OX=10090 GN=Akr7a2 PE=1 SV=3 0 23.722 25 7 12 7 367 40.6 8.12 3 6 3 3 6 3 24553269 18565645.38 18822733.5 6 6 5 metabolic process cytoplasm;cytosol;Golgi;mitochondrion catalytic activity Pf00248 110198 ENSMUSG00000028743.7 Akr7a5 4 Aflatoxin activation and detoxification Metabolism of xenobiotics by cytochrome P450 0 High Q8VEJ9 Vacuolar protein sorting-associated protein 4A OS=Mus musculus OX=10090 GN=Vps4a PE=1 SV=1 0 21.228 19 7 12 3 437 48.9 7.8 4 5 4 8 1197666.594 8299061 15361497.5 4 7 7 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane;nucleus;vacuole catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf04389, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401" 116733 ENSMUSG00000031913.9 Vps4a 8 Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 4 High P50247 Adenosylhomocysteinase OS=Mus musculus OX=10090 GN=Ahcy PE=1 SV=3 0 24.169 20 7 12 7 432 47.7 6.54 4 4 3 4 5 3 4307571.875 8123762.469 6208136.281 6 6 6 defense response;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00670, Pf02254, Pf02826, Pf05221" 269378; 11615 ENSMUSG00000048087.5; ENSMUSG00000027597.15 Ahcy; Gm4737 2; 16 Sulfur amino acid metabolism; Methylation Metabolic pathways; Cysteine and methionine metabolism 0 High B1ARA3 60S ribosomal protein L26 (Fragment) OS=Mus musculus OX=10090 GN=Rpl26 PE=1 SV=1 0 6.399 31 4 12 4 103 12.2 10.92 3 3 2 3 6 3 4178137.5 11470932.75 14543056 4 4 4 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00467 19941 ENSMUSG00000060938.14 Rpl26 11 0 High Q9CQ10 Charged multivesicular body protein 3 OS=Mus musculus OX=10090 GN=Chmp3 PE=1 SV=3 0 10.163 16 4 12 4 224 25.2 5.06 2 4 4 2 4 6 2849418.469 8452879.438 20824660.25 4 4 4 cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane protein binding Pf03357 66700 ENSMUSG00000053119.11 Chmp3 6 Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 High P62137 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Mus musculus OX=10090 GN=Ppp1ca PE=1 SV=1 0 22.852 22 6 12 3 330 37.5 6.33 2 5 4 2 6 4 1827984.219 8098169.938 10487988.31 5 6 6 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf00149 19045 ENSMUSG00000040385.6; ENSMUSG00000096994.2 Ppp1ca 19; CHR_MG153_PATCH DARPP-32 events; Signaling by GPCR Oxytocin signaling pathway; mRNA surveillance pathway; Herpes simplex infection; Regulation of actin cytoskeleton; Dopaminergic synapse; Focal adhesion; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Hippo signaling pathway; Platelet activation; Insulin resistance; Oocyte meiosis; Proteoglycans in cancer; cGMP-PKG signaling pathway; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 2 High Q4U2R1 E3 ubiquitin-protein ligase HERC2 OS=Mus musculus OX=10090 GN=Herc2 PE=1 SV=3 0 24.707 3 11 12 11 4836 527.1 6.27 6 6 6 6 917379.6797 4736065.188 5276416.531 5 9 8 metabolic process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00173, Pf00415, Pf00569, Pf00632, Pf03256, Pf06701, Pf11515, Pf13540" 15204 ENSMUSG00000030451.15 Herc2 7 G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Ubiquitin mediated proteolysis 0 High Q9D0S9 "Histidine triad nucleotide-binding protein 2, mitochondrial OS=Mus musculus OX=10090 GN=Hint2 PE=1 SV=1" 0 26.082 45 6 12 6 163 17.3 9.82 3 5 2 4 5 3 12434581 14267910.81 6642720.375 5 5 2 cell death;metabolic process;regulation of biological process mitochondrion catalytic activity;nucleotide binding "Pf01230, Pf11969" 68917 ENSMUSG00000028470.10 Hint2 4 0 High Q62425 Cytochrome c oxidase subunit NDUFA4 OS=Mus musculus OX=10090 GN=Ndufa4 PE=1 SV=2 0 11.993 56 5 12 5 82 9.3 9.52 3 5 2 3 6 3 13424254.56 32653188.25 26173802.25 5 5 3 metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf06522 17992 ENSMUSG00000029632.7 Ndufa4 6 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P26369 Splicing factor U2AF 65 kDa subunit OS=Mus musculus OX=10090 GN=U2af2 PE=1 SV=3 0 33.797 22 7 12 7 475 53.5 9.09 4 5 5 7 388628.6094 5513958.25 8101057.875 2 4 5 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22185 ENSMUSG00000030435.16 U2af2 7 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Spliceosome 0 High O55222 Integrin-linked protein kinase OS=Mus musculus OX=10090 GN=Ilk PE=1 SV=2 0 20.411 20 7 12 7 452 51.3 8.07 2 3 6 2 3 7 1435597.969 5763088.063 11791528.88 5 7 7 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00023, Pf00069, Pf07714, Pf12796, Pf13606, Pf13637, Pf13857" 16202 ENSMUSG00000030890.16 Ilk 7 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PPAR signaling pathway; Focal adhesion; Endometrial cancer; Axon guidance; Bacterial invasion of epithelial cells 0 High E9Q3Z5 Supervillin OS=Mus musculus OX=10090 GN=Svil PE=1 SV=1 0 33.496 7 9 12 9 2056 230.3 6.62 7 5 7 5 811468.2891 9289510.188 7589354.375 3 7 6 cell organization and biogenesis protein binding "Pf00626, Pf02209" ENSMUSG00000024236.18 18 0 High P11983 T-complex protein 1 subunit alpha OS=Mus musculus OX=10090 GN=Tcp1 PE=1 SV=3 0 30.005 21 9 12 9 556 60.4 6.16 1 2 8 1 2 9 1518942.523 6257795.938 12748577.44 5 7 9 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi nucleotide binding;protein binding;RNA binding Pf00118 21454 ENSMUSG00000068039.12 Tcp1 17 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High E9QNY3 Myosin regulatory light chain 10 OS=Mus musculus OX=10090 GN=Myl10 PE=1 SV=1 0 8.237 7 1 12 1 147 16.9 4.7 1 1 1 4 4 4 6309391 13542136.5 62106792 2 2 2 Met-loss [N-Term] mitochondrion metal ion binding;protein binding "Pf00036, Pf13405" 59310 ENSMUSG00000005474.9 Myl10 5 0 High P43274 Histone H1.4 OS=Mus musculus OX=10090 GN=H1-4 PE=1 SV=2 0 17.371 31 6 12 2 219 22 11.11 4 3 3 4 4 4 1975692.875 5192802.375 9620678.25 1 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00538 50709 ENSMUSG00000051627.2 Hist1h1e 13 0 High P80313 T-complex protein 1 subunit eta OS=Mus musculus OX=10090 GN=Cct7 PE=1 SV=1 0 18.137 13 7 12 7 544 59.6 7.84 2 4 5 2 4 6 1774247.109 5385313.719 8131470.375 7 7 6 metabolic process;regulation of biological process;transport cytoplasm;mitochondrion nucleotide binding;protein binding Pf00118 12468 ENSMUSG00000030007.8 Cct7 6 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High Q80SY3 V-type proton ATPase subunit d 2 OS=Mus musculus OX=10090 GN=Atp6v0d2 PE=2 SV=2 0 23.945 29 7 12 7 350 40.5 5.25 1 7 4 1 7 4 875902.5781 7306427.938 4536091.719 3 5 5 Acetyl [N-Term] cellular homeostasis;transport endosome;membrane catalytic activity;transporter activity Pf01992 242341 ENSMUSG00000028238.6 Atp6v0d2 4 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Lysosome; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion; Viral carcinogenesis 0 High P41105 60S ribosomal protein L28 OS=Mus musculus OX=10090 GN=Rpl28 PE=1 SV=2 0 12.511 28 4 12 4 137 15.7 12.02 2 4 2 2 6 4 5564227.656 10853245.25 13448553.75 4 4 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process membrane;ribosome RNA binding;structural molecule activity Pf01778 19943 ENSMUSG00000030432.12 Rpl28 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9DCX2 "ATP synthase subunit d, mitochondrial OS=Mus musculus OX=10090 GN=Atp5pd PE=1 SV=3" 0 22.979 43 5 12 5 161 18.7 5.69 2 2 4 3 3 6 1538983.469 3137678.938 9040433.875 3 3 3 metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;transporter activity Pf05873 71679 ENSMUSG00000034566.10 Atp5h 11 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High A7E1Z5 Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a4 PE=1 SV=1 0 26.574 9 6 12 6 1070 120.4 6.84 3 3 4 4 3 5 9065829.469 5946313.531 9763598.531 6 5 4 cellular homeostasis;transport membrane protein binding;transporter activity "Pf00359, Pf00955, Pf07565" 54403 ENSMUSG00000060961.14 Slc4a4 5 0 High Q9D1R9 60S ribosomal protein L34 OS=Mus musculus OX=10090 GN=Rpl34 PE=1 SV=2 0 9.009 28 4 12 4 117 13.3 11.47 2 4 3 2 5 5 6474427.5 14499911.25 18086658 4 4 3 metabolic process mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01199 619547; 68436; 100043876 ENSMUSG00000062006.12 Rpl34-ps1; Rpl34; Gm4705 6; 3; 17 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P14115 60S ribosomal protein L27a OS=Mus musculus OX=10090 GN=Rpl27a PE=1 SV=5 0 15.474 23 4 12 4 148 16.6 11.12 2 4 3 3 6 3 5557432.938 15919718.75 20410492.75 3 3 3 metabolic process cytosol;endoplasmic reticulum;membrane;ribosome RNA binding;structural molecule activity Pf00828 26451 ENSMUSG00000046364.14 Rpl27a 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O70475 UDP-glucose 6-dehydrogenase OS=Mus musculus OX=10090 GN=Ugdh PE=1 SV=1 0 22.578 15 5 12 5 493 54.8 7.56 1 4 4 1 5 6 1242339.957 3429393.188 6512252.75 4 3 4 metabolic process cytosol;nucleus catalytic activity;nucleotide binding "Pf00984, Pf03720, Pf03721" 22235 ENSMUSG00000029201.14 Ugdh 5 "Formation of the active cofactor, UDP-glucuronate" Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions 0 High H3BL49 T-complex protein 1 subunit theta OS=Mus musculus OX=10090 GN=Cct8 PE=1 SV=1 0 19.957 18 8 12 8 489 53 5.5 1 4 5 1 5 6 2124356.063 6287780.125 6655743.313 6 7 6 cell organization and biogenesis;metabolic process;transport nucleotide binding;protein binding Pf00118 ENSMUSG00000025613.13 16 0 High D3Z0M9 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 OS=Mus musculus OX=10090 GN=Ddx23 PE=1 SV=1 0 28.503 15 10 11 10 819 95.4 9.58 5 6 5 6 315699.2813 7822054.688 8705507.438 1 10 9 metabolic process cytoplasm;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf04851" 74351 ENSMUSG00000003360.14 Ddx23 15 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q8K2A1 PTB domain-containing engulfment adapter protein 1 OS=Mus musculus OX=10090 GN=Gulp1 PE=1 SV=1 0 16.506 18 6 11 6 304 34.4 7.9 2 4 4 2 4 5 4612295.438 8698473.188 15452032.56 5 4 4 cell death;cell organization and biogenesis;regulation of biological process;transport cytoplasm DNA binding;protein binding "Pf00640, Pf04977, Pf07716, Pf08416" 70676 ENSMUSG00000056870.9 Gulp1 1 0 High Q99M87 "DnaJ homolog subfamily A member 3, mitochondrial OS=Mus musculus OX=10090 GN=Dnaja3 PE=1 SV=1" 0 39.322 14 6 11 6 480 52.4 9.22 1 4 3 1 6 4 1824376.25 6720966.625 8072291.438 4 5 5 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 83945 ENSMUSG00000004069.16 Dnaja3 16 Viral carcinogenesis 0 High Q01149 Collagen alpha-2(I) chain OS=Mus musculus OX=10090 GN=Col1a2 PE=1 SV=2 0 11.562 4 5 11 5 1372 129.5 9.19 4 3 4 4 3 4 3502711.375 9166577.25 25401351.75 4 5 5 cell organization and biogenesis;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular metal ion binding;protein binding;structural molecule activity "Pf01391, Pf01410" 12843 ENSMUSG00000029661.16 Col1a2 6 Anchoring fibril formation; ECM proteoglycans; Cell surface interactions at the vascular wall; Platelet Aggregation (Plug Formation); Integrin cell surface interactions; Collagen degradation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Crosslinking of collagen fibrils; Collagen chain trimerization; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; MET activates PTK2 signaling; GPVI-mediated activation cascade; Non-integrin membrane-ECM interactions AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Platelet activation; Proteoglycans in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High A0A1L1SSF8 RIKEN cDNA 4931406C07 gene OS=Mus musculus OX=10090 GN=4931406C07Rik PE=1 SV=1 0 15.715 27 6 11 6 282 31.3 6.52 2 3 4 2 3 6 1236549.672 4798338.313 5621544.5 4 4 3 nucleus catalytic activity;metal ion binding Pf08925 70984 ENSMUSG00000031938.15 4931406C07Rik 9 0 High E9Q1W0 Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Mus musculus OX=10090 GN=Camk2d PE=1 SV=2 0 22.033 11 4 11 4 512 57.7 7.15 1 4 3 1 7 3 1139611.313 6333658.375 4762150.813 2 3 3 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf08332, Pf12680, Pf13474, Pf14534" 108058 ENSMUSG00000053819.16 Camk2d 3 0 High Q8C147 Dedicator of cytokinesis protein 8 OS=Mus musculus OX=10090 GN=Dock8 PE=1 SV=4 0 23.839 4 7 11 5 2100 238.8 6.96 1 3 5 1 4 6 502107.4844 1983696.547 5045762.203 2 5 6 cell proliferation;cellular component movement;regulation of biological process;response to stimulus cytoplasm;membrane protein binding "Pf06920, Pf11878, Pf14429" 76088 ENSMUSG00000052085.6 Dock8 19 Factors involved in megakaryocyte development and platelet production 1 High Q7TNG8 "Probable D-lactate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Ldhd PE=1 SV=1" 0 34.49 26 7 11 7 484 51.8 6.62 3 7 4 7 18633097.44 19778614.38 35382294.63 2 5 6 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf01565, Pf02913" 52815 ENSMUSG00000031958.16 Ldhd 8 Pyruvate metabolism 0 High P60843 Eukaryotic initiation factor 4A-I OS=Mus musculus OX=10090 GN=Eif4a1 PE=1 SV=1 0 28.356 17 5 11 4 406 46.1 5.48 2 4 4 2 4 5 723741.9414 4676358.625 7602517.5 3 4 4 metabolic process;regulation of biological process cytoplasm;membrane catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 13681 ENSMUSG00000059796.16 Eif4a1 11 L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Translation initiation complex formation; Deadenylation of mRNA RNA transport 0 High E9Q7U2 Calcium-binding and coiled-coil domain-containing protein 1 OS=Mus musculus OX=10090 GN=Calcoco1 PE=1 SV=1 0 28.071 13 7 11 7 633 70.9 4.86 6 4 6 5 422878.4531 5207583.625 4953398.375 2 5 4 cellular component movement;metabolic process;regulation of biological process;response to stimulus catalytic activity;motor activity;protein binding "Pf01576, Pf04111, Pf05667, Pf06008, Pf07888, Pf09789, Pf12128, Pf13514, Pf13851" ENSMUSG00000023055.9 15 0 High Q6AXE3 ATP-binding cassette sub-family A member 3 OS=Mus musculus OX=10090 GN=Abca3 PE=1 SV=1 0.003 3.551 1 1 11 1 1449 163.4 7.83 1 1 1 3 4 4 135445303 190116135 72725064.5 1 1 1 transport membrane catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf03193, Pf12698, Pf13304, Pf13476" 27410 ENSMUSG00000024130.15 Abca3 17 ABC transporters 0 High Q8VDM4 26S proteasome non-ATPase regulatory subunit 2 OS=Mus musculus OX=10090 GN=Psmd2 PE=1 SV=1 0 21.874 10 7 11 7 908 100.1 5.17 1 5 5 1 5 5 648455.3359 4916146.375 3436733.188 3 6 5 metabolic process;regulation of biological process membrane;nucleus;proteasome catalytic activity;enzyme regulator activity;protein binding Pf01851 21762 ENSMUSG00000006998.15 Psmd2 16 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High A6BLY7 "Keratin, type I cytoskeletal 28 OS=Mus musculus OX=10090 GN=Krt28 PE=1 SV=1" 0 8.19 3 2 11 1 462 50.3 5.29 2 2 2 5 3 3 26824576.13 9266232.75 12216277.75 3 2 2 cytoplasm structural molecule activity Pf00038 70843 ENSMUSG00000055937.1 Krt28 11 Formation of the cornified envelope 0 High G5E866 Splicing factor 3B subunit 1 OS=Mus musculus OX=10090 GN=Sf3b1 PE=1 SV=1 0 22.975 10 8 11 8 1304 145.7 7.09 2 8 2 9 84297.19531 4072304.875 6774828.125 1 5 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus;spliceosomal complex DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity "Pf02161, Pf08920, Pf12815, Pf13513" 81898 ENSMUSG00000025982.13 Sf3b1 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; B-WICH complex positively regulates rRNA expression Spliceosome 0 High Q9JKR6 Hypoxia up-regulated protein 1 OS=Mus musculus OX=10090 GN=Hyou1 PE=1 SV=1 0 31.566 10 8 11 8 999 111.1 5.19 8 3 8 3 200640.25 9970823.25 6718435.844 2 7 7 regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;membrane;organelle lumen nucleotide binding Pf00012 12282 ENSMUSG00000032115.14 Hyou1 9 Protein processing in endoplasmic reticulum 0 High P60867 40S ribosomal protein S20 OS=Mus musculus OX=10090 GN=Rps20 PE=1 SV=1 0 11.278 25 3 11 3 119 13.4 9.94 2 3 3 3 3 5 3151026.125 6791644.25 12792828.25 2 2 2 metabolic process cytoplasm;membrane;ribosome RNA binding;structural molecule activity Pf00338 67427 ENSMUSG00000028234.6 Rps20 4 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9QXY6 EH domain-containing protein 3 OS=Mus musculus OX=10090 GN=Ehd3 PE=1 SV=2 0 25.462 14 7 11 2 535 60.8 6.46 4 6 4 7 188828.3047 227591.8438 902816.7813 2 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 57440 ENSMUSG00000024065.7 Ehd3 17 Factors involved in megakaryocyte development and platelet production Endocytosis 0 High A2AR02 Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 0 16.167 6 4 11 4 752 88.3 10.27 3 3 2 4 4 3 8763462.09 6795223 5479331.125 4 3 3 metabolic process cytosol;nucleus catalytic activity;RNA binding Pf00160 228005 ENSMUSG00000042133.16 Ppig 2 0 High P07901 Heat shock protein HSP 90-alpha OS=Mus musculus OX=10090 GN=Hsp90aa1 PE=1 SV=4 0 25.307 11 7 11 1 733 84.7 5.01 1 4 5 1 5 5 1635892.281 4732904 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 15519 ENSMUSG00000021270.13 Hsp90aa1 12 "Anchoring of the basal body to the plasma membrane; The role of GTSE1 in G2/M progression after G2 checkpoint; VEGFR2 mediated vascular permeability; Downregulation of ERBB2 signaling; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; Attenuation phase; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR); eNOS activation; Sema3A PAK dependent Axon repulsion; EPHB-mediated forward signaling" Progesterone-mediated oocyte maturation; NOD-like receptor signaling pathway; Pathways in cancer; Antigen processing and presentation; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Prostate cancer 0 High E9Q2E5 Rap guanine nucleotide exchange factor 3 OS=Mus musculus OX=10090 GN=Rapgef3 PE=1 SV=1 0 27.122 8 5 11 5 909 102.3 7.47 5 4 6 5 1867147.383 4797214.906 5454371.188 5 5 5 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane nucleotide binding;protein binding "Pf00027, Pf00610, Pf00617, Pf00618" 223864 ENSMUSG00000022469.16 Rapgef3 15 0 High A2API8 Paralemmin A kinase anchor protein OS=Mus musculus OX=10090 GN=Pakap PE=1 SV=1 0 19.344 8 6 11 6 921 101.5 5.2 1 5 3 1 6 4 808336.2813 7808364 5104789.063 3 5 4 cell organization and biogenesis;regulation of biological process;response to stimulus protein binding 11641 ENSMUSG00000038729.23 Akap2 4 0 High Q9DB34 Charged multivesicular body protein 2a OS=Mus musculus OX=10090 GN=Chmp2a PE=1 SV=1 0 10.661 18 5 11 5 222 25.1 5.97 3 2 3 3 3 5 3073159.719 7541390.188 10973618.75 4 5 5 Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport chromosome;cytoplasm;cytosol;endosome;membrane protein binding Pf03357 68953 ENSMUSG00000033916.5 Chmp2a 7 Macroautophagy; Lysosome Vesicle Biogenesis; Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 High Q61767 NADPH-dependent 3-keto-steroid reductase Hsd3b4 OS=Mus musculus OX=10090 GN=Hsd3b4 PE=1 SV=3 0 33.811 33 8 11 4 373 41.7 8.57 1 3 5 1 4 6 806378 3389717.344 7014240.875 3 4 5 Met-loss [N-Term] metabolic process;response to stimulus endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding "Pf01073, Pf01370, Pf02719, Pf04321, Pf05368, Pf07993, Pf13460" 100043456; 15495 ENSMUSG00000095143.5; ENSMUSG00000095388.7 Gm10681; Hsd3b4 3 Glucocorticoid biosynthesis; Androgen biosynthesis; Mineralocorticoid biosynthesis Steroid hormone biosynthesis; Ovarian steroidogenesis; Metabolic pathways; Aldosterone synthesis and secretion 4 High Q91V55 40S ribosomal protein S5 OS=Mus musculus OX=10090 GN=Rps5 PE=1 SV=1 0 19.038 40 6 11 6 204 22.9 9.72 2 3 6 2 3 6 7507338.125 20156736.28 28675142.25 4 6 6 cell organization and biogenesis;metabolic process;regulation of biological process membrane;ribosome RNA binding;structural molecule activity Pf00177 20103 ENSMUSG00000012848.15 Rps5 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P19324 Serpin H1 OS=Mus musculus OX=10090 GN=Serpinh1 PE=1 SV=3 0 22.032 22 7 11 7 417 46.5 8.82 7 4 7 4 445586.2813 7231863.75 7914077.938 2 6 6 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;organelle lumen enzyme regulator activity;protein binding;RNA binding Pf00079 12406 ENSMUSG00000070436.12 Serpinh1 7 Collagen biosynthesis and modifying enzymes 0 High Q61235 Beta-2-syntrophin OS=Mus musculus OX=10090 GN=Sntb2 PE=1 SV=2 0 24.052 19 9 11 8 520 56.3 8.69 2 2 6 3 2 6 2606225.797 6681426.875 7712690.719 7 7 8 cytoplasm;cytoskeleton;membrane protein binding;RNA binding;structural molecule activity "Pf00169, Pf00595, Pf13180" 20650 ENSMUSG00000041308.6 Sntb2 8 1 High A0A0R4IZW5 Cadherin-1 OS=Mus musculus OX=10090 GN=Cdh1 PE=1 SV=1 0 22.211 10 7 10 7 884 98.2 4.84 3 4 3 3 4 3 3667178.125 4430810.563 4274474.5 4 5 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;endosome;Golgi;membrane metal ion binding;protein binding "Pf00028, Pf01049, Pf08758" 12550 ENSMUSG00000000303.12 Cdh1 8 RHO GTPases activate IQGAPs; Degradation of the extracellular matrix; Integrin cell surface interactions; Adherens junctions interactions; Apoptotic cleavage of cell adhesion proteins Endometrial cancer; Hippo signaling pathway; Melanoma; Cell adhesion molecules (CAMs); Adherens junction; Rap1 signaling pathway; Pathways in cancer; Thyroid cancer; Bladder cancer; Bacterial invasion of epithelial cells 0 High Q5S006 Leucine-rich repeat serine/threonine-protein kinase 2 OS=Mus musculus OX=10090 GN=Lrrk2 PE=1 SV=2 0 27.19 4 7 10 7 2527 284.5 6.83 1 3 5 1 4 5 995308.6172 4068391.219 4470091.438 3 7 6 cell communication;cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus;organelle lumen;vacuole catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity;structural molecule activity "Pf00025, Pf00069, Pf00071, Pf07714, Pf08477, Pf12799, Pf13855" 66725 ENSMUSG00000036273.15 Lrrk2 15 PTK6 promotes HIF1A stabilization Parkinson's disease 0 High O89017 Legumain OS=Mus musculus OX=10090 GN=Lgmn PE=1 SV=1 0 27.733 18 5 10 5 435 49.3 6.39 3 4 5 5 4435383.5 13753589.5 26888863.25 1 3 5 metabolic process;regulation of biological process;response to stimulus endosome;vacuole catalytic activity Pf01650 19141 ENSMUSG00000021190.14 Lgmn 12 MHC class II antigen presentation; Vitamin D (calciferol) metabolism; Trafficking and processing of endosomal TLR Lysosome; Antigen processing and presentation 0 High Q9CQM8 60S ribosomal protein L21 OS=Mus musculus OX=10090 GN=Rpl21 PE=1 SV=1 0 10.627 21 4 10 4 160 18.6 10.49 2 3 3 2 4 4 1081174.773 14026876.5 15344600.75 3 3 3 metabolic process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01157 19933; 676253; 100503563; 675278 ENSMUSG00000041453.12 Rpl21; Gm14648; Gm10240; Rpl21-ps15 5; X; 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62849 40S ribosomal protein S24 OS=Mus musculus OX=10090 GN=Rps24 PE=1 SV=1 0 17.339 35 5 10 5 133 15.4 10.78 2 3 5 2 3 5 1750472.813 7346627 9287036.063 4 5 5 Acetyl [N-Term] metabolic process membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01282 20088; 102642752 ENSMUSG00000025290.16 Rps24; LOC677113; LOC102642752 14; 16 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P62259 14-3-3 protein epsilon OS=Mus musculus OX=10090 GN=Ywhae PE=1 SV=1 0 15.718 26 6 10 4 255 29.2 4.74 1 2 6 1 2 7 1427153.5 4697609.563 6350876 2 3 4 Acetyl [N-Term] cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding Pf00244 22627 ENSMUSG00000020849.13 Ywhae 11 Activation of BAD and translocation to mitochondria ; Loss of Nlp from mitotic centrosomes; Recruitment of NuMA to mitotic centrosomes; TP53 Regulates Metabolic Genes; Signaling by Hippo; Translocation of GLUT4 to the plasma membrane; Anchoring of the basal body to the plasma membrane; Regulation of HSF1-mediated heat shock response; AURKA Activation by TPX2; RHO GTPases activate PKNs; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; RAB GEFs exchange GTP for GDP on RABs; Regulation of PLK1 Activity at G2/M Transition; NADE modulates death signalling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signalling by NGF Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Neurotrophin signaling pathway; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High Q922B2 "Aspartate--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Dars1 PE=1 SV=2" 0 25.302 17 7 10 7 501 57.1 6.49 1 5 4 1 5 4 854185.9219 36680547.13 9305276.688 3 6 6 metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;RNA binding "Pf00152, Pf01336" 226414 ENSMUSG00000026356.15 Dars 1 Aminoacyl-tRNA biosynthesis 0 High P80316 T-complex protein 1 subunit epsilon OS=Mus musculus OX=10090 GN=Cct5 PE=1 SV=1 0 31.552 22 7 10 7 541 59.6 6.02 5 5 5 5 3435483.563 6539148.813 4 4 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 12465 ENSMUSG00000022234.14 Cct5 15 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High Q8VCH0 "3-ketoacyl-CoA thiolase B, peroxisomal OS=Mus musculus OX=10090 GN=Acaa1b PE=1 SV=1" 0 34.763 16 5 10 2 424 44 8.51 3 5 3 7 1386826.813 7888176.793 16403896 2 3 4 metabolic process mitochondrion catalytic activity "Pf00108, Pf02803, Pf08541" 235674 ENSMUSG00000010651.4 Acaa1b 9 Beta-oxidation of very long chain fatty acids; Neutrophil degranulation; alpha-linolenic acid (ALA) metabolism "PPAR signaling pathway; Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Peroxisome" 3 High P46467 Vacuolar protein sorting-associated protein 4B OS=Mus musculus OX=10090 GN=Vps4b PE=1 SV=2 0 19.373 16 6 10 2 444 49.4 7.11 4 4 4 6 732627.4766 946307.9688 2292304.75 2 2 2 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401" 20479 ENSMUSG00000009907.17 Vps4b 1 Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 High P61205 ADP-ribosylation factor 3 OS=Mus musculus OX=10090 GN=Arf3 PE=2 SV=2 0 26.741 41 5 10 3 181 20.6 7.43 1 4 4 1 4 5 1931213.719 7487603.688 10770159.63 4 4 5 regulation of biological process;response to stimulus;transport cytoplasm;Golgi catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 11842 ENSMUSG00000051853.9 Arf3 15 Synthesis of PIPs at the Golgi membrane Endocytosis 2 High Q9JIX8 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus OX=10090 GN=Acin1 PE=1 SV=3 0 26.581 8 6 10 6 1338 150.6 5.91 5 4 5 5 139225.75 9640062.5 10778216.44 1 4 4 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane;nucleus RNA binding "Pf02037, Pf13893" 56215 ENSMUSG00000022185.18 Acin1 14 Apoptotic cleavage of cellular proteins mRNA surveillance pathway; Spliceosome; RNA transport 0 High Q80U72 Protein scribble homolog OS=Mus musculus OX=10090 GN=Scrib PE=1 SV=2 0 36.015 9 7 10 6 1612 174 5.12 5 4 5 5 717539.5625 4553042.125 5327523.594 2 3 4 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;protein binding "Pf00595, Pf12799, Pf13180, Pf13855, Pf14580" 105782 ENSMUSG00000022568.16 Scrib 15 Hippo signaling pathway; Viral carcinogenesis 1 High Q8QZT1 "Acetyl-CoA acetyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Acat1 PE=1 SV=1" 0 19.834 16 6 10 6 424 44.8 8.51 1 4 5 1 4 5 3411035.25 7768966.125 11322532 6 6 6 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00108, Pf00109, Pf02803" 110446 ENSMUSG00000032047.5 Acat1 9 Synthesis of Ketone Bodies; Utilization of Ketone Bodies; Branched-chain amino acid catabolism "Fatty acid metabolism; Pyruvate metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Terpenoid backbone biosynthesis; Lysine degradation; Fatty acid degradation; Butanoate metabolism; Propanoate metabolism; Synthesis and degradation of ketone bodies; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High Q3UV17 "Keratin, type II cytoskeletal 2 oral OS=Mus musculus OX=10090 GN=Krt76 PE=1 SV=1" 0 9.646 5 4 10 1 594 62.8 8.43 3 3 1 6 3 1 29003722 16758291 20571692 1 1 1 nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf10473" 77055 ENSMUSG00000075402.1 Krt76 15 Formation of the cornified envelope 0 High Q64727 Vinculin OS=Mus musculus OX=10090 GN=Vcl PE=1 SV=4 0 17.263 6 5 10 5 1066 116.6 6 4 1 3 6 1 3 3992130.875 3736595.688 8441739.063 4 3 4 cell growth;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity Pf01044 22330 ENSMUSG00000021823.9 Vcl 14 Platelet degranulation ; Neutrophil degranulation; Smooth Muscle Contraction Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Focal adhesion; Adherens junction; Amoebiasis; Bacterial invasion of epithelial cells 0 High P63094 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short OS=Mus musculus OX=10090 GN=Gnas PE=1 SV=1 0 15.46 19 5 10 4 394 45.6 5.96 3 3 4 3 3 4 2217354.844 3873212.563 6275985.625 4 4 4 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;extracellular;Golgi;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503, Pf08477" 14683 ENSMUSG00000027523.19 Gnas 2 PKA activation in glucagon signalling; Prostacyclin signalling through prostacyclin receptor; Hedgehog 'off' state; Glucagon-type ligand receptors; G alpha (s) signalling events; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Oxytocin signaling pathway; Morphine addiction; Chagas disease (American trypanosomiasis); Phospholipase D signaling pathway; Pancreatic secretion; Dopaminergic synapse; Regulation of lipolysis in adipocytes; Ovarian steroidogenesis; Amphetamine addiction; Endocrine and other factor-regulated calcium reabsorption; Platelet activation; Melanogenesis; Dilated cardiomyopathy; Thyroid hormone synthesis; Glutamatergic synapse; Cocaine addiction; Long-term depression; Rap1 signaling pathway; Pathways in cancer; Calcium signaling pathway; Bile secretion; Salivary secretion; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Vasopressin-regulated water reabsorption; Gastric acid secretion; Renin secretion; Gap junction; Circadian entrainment; Insulin secretion; Estrogen signaling pathway; Amoebiasis; Glucagon signaling pathway; Serotonergic synapse; Adrenergic signaling in cardiomyocytes; Endocrine resistance; Inflammatory mediator regulation of TRP channels 0 High A2AEX6 Four and a half LIM domains protein 1 OS=Mus musculus OX=10090 GN=Fhl1 PE=1 SV=1 0 19.412 25 6 10 6 309 35.1 8.44 1 3 5 1 3 6 7755219.266 18880997.13 30818956 5 5 5 cell differentiation;development;regulation of biological process cytoplasm;cytosol;membrane;nucleus metal ion binding;protein binding Pf00412 14199 ENSMUSG00000023092.16 Fhl1 X 0 High P11930 Nucleoside diphosphate-linked moiety X motif 19 OS=Mus musculus OX=10090 GN=Nudt19 PE=1 SV=2 0 22.247 23 7 10 7 357 40.3 6.68 2 1 5 2 1 7 2690292.047 4730226.156 7427361.813 5 6 6 mitochondrion catalytic activity;metal ion binding;protein binding 110959 ENSMUSG00000034875.5 Nudt19 7 Peroxisomal lipid metabolism Peroxisome 0 High E9Q317 Histone deacetylase complex subunit SAP18 OS=Mus musculus OX=10090 GN=Sap18 PE=1 SV=1 0 19.538 30 5 10 5 172 19.6 9.8 1 4 3 1 6 3 509605.6172 17158476.38 6985094 3 4 3 regulation of biological process cytosol protein binding;RNA binding Pf06487 20220; 100041953 ENSMUSG00000021963.16; ENSMUSG00000061104.5 Sap18; Gm10094; Sap18b 14; 8 mRNA surveillance pathway; RNA transport 0 High Q9D0M3 "Cytochrome c1, heme protein, mitochondrial OS=Mus musculus OX=10090 GN=Cyc1 PE=1 SV=1" 0 19.361 15 4 10 4 325 35.3 9.16 1 1 4 2 1 7 2277912.875 5641880.5 6735092.625 4 4 4 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus metal ion binding;protein binding Pf02167 66445 ENSMUSG00000022551.7 Cyc1 15 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q8BL97 Serine/arginine-rich splicing factor 7 OS=Mus musculus OX=10090 GN=Srsf7 PE=1 SV=1 0 18.105 19 5 10 4 267 30.8 11.9 2 5 2 2 6 2 359633.2813 21304005 27605647.5 1 4 3 metabolic process;regulation of biological process;transport cytoplasm;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 225027 Srsf7 17 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High P60335 Poly(rC)-binding protein 1 OS=Mus musculus OX=10090 GN=Pcbp1 PE=1 SV=1 0 15.363 13 4 10 2 356 37.5 7.09 2 4 4 6 2429498.875 10427595.75 16420766.5 3 4 4 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding;translation regulator activity "Pf00013, Pf13014" 23983 ENSMUSG00000051695.6 Pcbp1 6 mRNA Splicing - Major Pathway Spliceosome 2 High G3X8Q5 Ceruloplasmin OS=Mus musculus OX=10090 GN=Cp PE=1 SV=1 0 26.713 11 7 10 7 1085 124.1 5.88 5 4 5 5 2112020 7217874.219 8889603.875 5 6 6 cellular homeostasis;metabolic process;response to stimulus;transport extracellular;membrane catalytic activity;metal ion binding;protein binding "Pf00394, Pf07731, Pf07732" 12870 ENSMUSG00000003617.16 Cp 3 0 High Q61233 Plastin-2 OS=Mus musculus OX=10090 GN=Lcp1 PE=1 SV=4 0 12.748 9 4 9 1 627 70.1 5.33 1 4 2 1 5 3 24175.27148 549386.125 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane metal ion binding;protein binding "Pf00036, Pf00307, Pf13405, Pf13499, Pf13833" 18826 ENSMUSG00000021998.16 Lcp1 14 0 High Q61425 "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Hadh PE=1 SV=2" 0 18.501 37 6 9 6 314 34.4 8.65 3 3 3 3 3 3 2858100.844 3784124.75 5317306.125 4 4 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00070, Pf00725, Pf01266, Pf02737, Pf13450" 15107 ENSMUSG00000027984.8 Hadh 3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; Fatty acid elongation" 0 High A2A6J7 Lymphocyte-specific protein 1 OS=Mus musculus OX=10090 GN=Lsp1 PE=1 SV=1 0 21.708 15 4 9 4 324 35.9 4.73 2 4 4 5 1036900.813 6888339.625 10123815.38 3 3 3 cell death;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus membrane protein binding;signal transducer activity Pf02029 16985 ENSMUSG00000018819.10 Lsp1 7 0 High Q8VC30 Triokinase/FMN cyclase OS=Mus musculus OX=10090 GN=Tkfc PE=1 SV=1 0 24.867 18 6 9 6 578 59.7 6.92 3 5 4 5 488362.4688 3660267.438 6997110.563 2 5 6 metabolic process;regulation of biological process nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf02733, Pf02734" 225913 ENSMUSG00000034371.8 Dak; Tkfc 19 Fructose catabolism Metabolic pathways; RIG-I-like receptor signaling pathway; Carbon metabolism; Glycerolipid metabolism; Fructose and mannose metabolism 0 High Q9CQN1 "Heat shock protein 75 kDa, mitochondrial OS=Mus musculus OX=10090 GN=Trap1 PE=1 SV=1" 0 33.827 11 6 9 5 706 80.2 6.68 3 5 4 5 6430264.563 14492577.63 8745172.625 2 4 4 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 68015 ENSMUSG00000005981.11 Trap1 16 0 High B2RXP1 DISP complex protein LRCH3 OS=Mus musculus OX=10090 GN=Lrch3 PE=1 SV=1 0 19.81 12 7 9 6 742 82.2 6.77 1 4 3 1 4 4 410038.5625 4924206.938 4686889.375 2 5 4 regulation of biological process;response to stimulus cytosol;extracellular;membrane protein binding "Pf00307, Pf12799, Pf13855" 70144 ENSMUSG00000022801.13 Lrch3 16 1 High O54833 Casein kinase II subunit alpha' OS=Mus musculus OX=10090 GN=Csnk2a2 PE=1 SV=1 0 22.951 20 6 9 6 350 41.2 8.56 1 6 2 1 6 2 1617884.688 5978145.563 8182954.125 4 5 4 cell death;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 13000 ENSMUSG00000046707.9 Csnk2a2 8 WNT mediated activation of DVL; Regulation of TP53 Activity through Phosphorylation; Synthesis of PC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Condensation of Prometaphase Chromosomes; Receptor Mediated Mitophagy; Regulation of PTEN stability and activity; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Herpes simplex infection; Wnt signaling pathway; Epstein-Barr virus infection; Adherens junction; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Tight junction; Measles 0 High F8WH20 Oxysterol-binding protein OS=Mus musculus OX=10090 GN=Osbpl3 PE=1 SV=1 0 25.148 14 8 9 8 819 93 6.54 6 3 6 3 558289.7188 9837363.969 12170317.13 2 6 6 transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus "Pf00169, Pf01237, Pf15409, Pf15413" 71720 ENSMUSG00000029822.15 Osbpl3 6 0 High Q8R050 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Mus musculus OX=10090 GN=Gspt1 PE=1 SV=2 0 12.76 13 6 9 6 636 68.6 5.21 1 4 3 1 4 4 372016.4063 3617872.469 6369125.375 1 5 4 cell organization and biogenesis;metabolic process cytosol catalytic activity;nucleotide binding;RNA binding "Pf00009, Pf03143, Pf03144, Pf07145" 14852 ENSMUSG00000062203.14 Gspt1 16 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination mRNA surveillance pathway 0 High Q9WTX5 S-phase kinase-associated protein 1 OS=Mus musculus OX=10090 GN=Skp1 PE=1 SV=3 0 12.779 38 4 9 4 163 18.7 4.54 1 3 4 1 3 5 1401404.355 4047984.953 7415928 3 3 3 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf01466, Pf03931" 21402 ENSMUSG00000036309.14 Skp1a 11 NIK-->noncanonical NF-kB signaling; Degradation of beta-catenin by the destruction complex; Prolactin receptor signaling; SCF-beta-TrCP mediated degradation of Emi1; Regulation of RUNX2 expression and activity; SCF(Skp2)-mediated degradation of p27/p21; Neddylation; GLI3 is processed to GLI3R by the proteasome; Dectin-1 mediated noncanonical NF-kB signaling; Activation of NF-kappaB in B cells; Activated TLR4 signalling; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Regulation of PLK1 Activity at G2/M Transition; Downstream TCR signaling; Cyclin D associated events in G1; Interleukin-1 family signaling; Iron uptake and transport; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; MAP3K8 (TPL2)-dependent MAPK1/3 activation Herpes simplex infection; Wnt signaling pathway; Ubiquitin mediated proteolysis; Circadian rhythm; Oocyte meiosis; Cell cycle; TGF-beta signaling pathway; Protein processing in endoplasmic reticulum 0 High Q9JJU8 SH3 domain-binding glutamic acid-rich-like protein OS=Mus musculus OX=10090 GN=Sh3bgrl PE=1 SV=1 0 15.886 46 4 9 4 114 12.8 4.92 2 4 3 6 524722.625 4784495.813 8011340.625 1 3 4 cellular homeostasis;regulation of biological process cytoplasm catalytic activity;protein binding "Pf00462, Pf04908" 56726 ENSMUSG00000031246.14 Sh3bgrl X 0 High Q6ZWU9 40S ribosomal protein S27 OS=Mus musculus OX=10090 GN=Rps27 PE=1 SV=3 0 8.921 38 3 9 1 84 9.5 9.45 1 3 3 1 3 5 377311.9375 1415937.25 1483730.75 1 1 1 cell organization and biogenesis;metabolic process ribosome metal ion binding;protein binding;structural molecule activity Pf01667 57294; 100043813 ENSMUSG00000090733.6; ENSMUSG00000050621.7 Rps27; Gm9846; Rps27rt 3; 9 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Formation of a pool of free 40S subunits; Translation initiation complex formation; L13a-mediated translational silencing of Ceruloplasmin expression; Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Ribosomal scanning and start codon recognition; RHO GTPases Activate Formins; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex" Ribosome 0 High Q99K41 EMILIN-1 OS=Mus musculus OX=10090 GN=Emilin1 PE=1 SV=1 0 24.235 11 7 9 7 1017 107.5 5.3 2 4 3 2 4 3 1251961.57 3514684.531 6272041.188 5 6 5 cell organization and biogenesis;cellular component movement;regulation of biological process extracellular protein binding;structural molecule activity "Pf00386, Pf07546" 100952 ENSMUSG00000029163.9 Emilin1 5 0 High Q9D8B3 Charged multivesicular body protein 4b OS=Mus musculus OX=10090 GN=Chmp4b PE=1 SV=2 0 27.562 23 5 9 5 224 24.9 4.82 2 4 2 2 4 3 3922947.344 17557729.13 20861480.56 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane;nucleus protein binding Pf03357 75608 ENSMUSG00000038467.15 Chmp4b 2 Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 High P45952 "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadm PE=1 SV=1" 0 23.953 22 6 9 6 421 46.5 8.37 1 4 4 1 4 4 3082401.266 9347009.875 12489525 6 5 5 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00441, Pf02770, Pf02771, Pf08028" 11364 ENSMUSG00000062908.12 Acadm 3 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA "PPAR signaling pathway; Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; beta-Alanine metabolism; Propanoate metabolism; Carbon metabolism" 0 High P10649 Glutathione S-transferase Mu 1 OS=Mus musculus OX=10090 GN=Gstm1 PE=1 SV=2 0 16.21 24 6 9 6 218 26 7.94 1 2 6 1 2 6 1636460.68 2412822.031 3776029.313 4 4 6 metabolic process;response to stimulus cytoplasm;cytosol;extracellular catalytic activity;metal ion binding;protein binding "Pf00043, Pf02798, Pf13417, Pf14497" 14862 ENSMUSG00000058135.12 Gstm1 3 Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 High Q7TQG1 Pleckstrin homology domain-containing family A member 6 OS=Mus musculus OX=10090 GN=Plekha6 PE=1 SV=1 0 14.628 4 5 9 5 1173 131.3 8.97 3 1 4 4 1 4 3639856 5741338.156 6377465.813 5 4 4 "Pf00169, Pf14593, Pf15413" 240753 ENSMUSG00000041757.16 Plekha6 1 0 High Q60710 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Mus musculus OX=10090 GN=Samhd1 PE=1 SV=3 0 23.918 12 5 9 5 658 75.8 7.93 4 4 5 4 241061.4375 2923903.469 3900929.281 1 4 4 0 High Q6ZWV7 60S ribosomal protein L35 OS=Mus musculus OX=10090 GN=Rpl35 PE=1 SV=1 0 7.349 19 2 9 2 123 14.5 11.05 1 2 2 2 3 4 2637647.969 6545421.75 11952475 2 2 2 metabolic process;response to stimulus membrane;ribosome RNA binding;structural molecule activity Pf00831 66489 ENSMUSG00000078193.2; ENSMUSG00000062997.6 Rpl35 2; 1 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A2AUR3 Phosphotriesterase-related protein (Fragment) OS=Mus musculus OX=10090 GN=Pter PE=1 SV=2 0 31.32 23 5 9 5 321 35.8 6.38 1 2 4 1 2 6 1167376.813 6068303.75 12043816.25 4 5 5 metabolic process catalytic activity;metal ion binding "Pf01026, Pf02126" ENSMUSG00000026730.12 2 0 High O09173 "Homogentisate 1,2-dioxygenase OS=Mus musculus OX=10090 GN=Hgd PE=1 SV=2" 0 24.749 20 6 9 6 445 49.9 7.24 3 6 3 6 740450.5547 4606250.75 4087765.438 3 6 5 metabolic process catalytic activity;metal ion binding;protein binding Pf04209 15233 ENSMUSG00000022821.13 Hgd 16 Phenylalanine and tyrosine catabolism Metabolic pathways; Tyrosine metabolism 0 High P42125 "Enoyl-CoA delta isomerase 1, mitochondrial OS=Mus musculus OX=10090 GN=Eci1 PE=1 SV=2" 0 16.452 28 5 9 5 289 32.2 8.98 2 5 3 6 788406.9453 4707197.375 7032081.281 3 5 5 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding Pf00378 13177 ENSMUSG00000024132.5 Eci1 17 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Fatty acid degradation 0 High Q5SX75 Prolyl 4-hydroxylase subunit alpha-2 OS=Mus musculus OX=10090 GN=P4ha2 PE=1 SV=1 0 22.419 17 6 9 6 537 61 5.9 4 5 4 5 640169.2266 6655594.625 5849701.563 3 6 5 metabolic process cytosol;endoplasmic reticulum catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336, Pf13640" 18452 ENSMUSG00000018906.14 P4ha2 11 Arginine and proline metabolism; Metabolic pathways 0 High Q3THW5 Histone H2A.V OS=Mus musculus OX=10090 GN=H2az2 PE=1 SV=3 0 8.098 23 3 9 1 128 13.5 10.58 2 1 3 4 2 3 221004.3906 343162 686004.3125 1 1 1 regulation of biological process chromosome;nucleus DNA binding;protein binding Pf00125 77605 ENSMUSG00000041126.16 H2afv 11 Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus 0 High E9Q133 T-complex protein 1 subunit gamma OS=Mus musculus OX=10090 GN=Cct3 PE=1 SV=1 0 24.318 16 6 9 6 507 56.5 6.7 1 3 4 1 3 5 646587.0469 2800441.906 6429773.375 2 3 4 cell organization and biogenesis;metabolic process;transport cytoplasm nucleotide binding;protein binding Pf00118 ENSMUSG00000001416.13 3 0 High Q91WQ9 Calmodulin-like protein 4 OS=Mus musculus OX=10090 GN=Calml4 PE=1 SV=2 0 10.461 27 4 9 4 153 17.7 7.96 2 2 4 2 2 5 1783677.594 5566169.125 8318580.125 4 4 4 metal ion binding "Pf13499, Pf13833, Pf14658" 75600 ENSMUSG00000032246.14 Calml4 9 Oxytocin signaling pathway; Dopaminergic synapse; Ras signaling pathway; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Tuberculosis; Melanogenesis; Oocyte meiosis; Pertussis; Neurotrophin signaling pathway; cGMP-PKG signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Olfactory transduction; Phototransduction; Gastric acid secretion; Renin secretion; Circadian entrainment; Glioma; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 0 High A0A338P6T4 AP-2 complex subunit mu (Fragment) OS=Mus musculus OX=10090 GN=Ap2m1 PE=1 SV=1 0 17.416 45 3 9 1 119 13.7 5.2 2 3 2 3 4 2 357035.4375 710371.1875 1 1 0 High Q99N23 Carbonic anhydrase 15 OS=Mus musculus OX=10090 GN=Ca15 PE=1 SV=1 0 24.66 27 5 9 5 324 35.5 6.79 1 2 4 1 2 6 1165208.125 39116307.81 40296928.88 2 3 5 extracellular;membrane catalytic activity;metal ion binding Pf00194 80733 ENSMUSG00000090236.2 Car15 16 Nitrogen metabolism 0 High Q9Z1G4 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus OX=10090 GN=Atp6v0a1 PE=1 SV=3 0 20.404 10 6 9 6 839 96.4 6.76 2 5 2 2 5 2 1157059.969 5533663.813 3204435.5 5 6 4 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;protein binding;transporter activity Pf01496 11975 ENSMUSG00000019302.16 Atp6v0a1 11 "Ion channel transport; ROS, RNS production in phagocytes; Neutrophil degranulation; Transferrin endocytosis and recycling; Insulin receptor recycling" Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Lysosome; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High P67778 Prohibitin OS=Mus musculus OX=10090 GN=Phb PE=1 SV=1 0 12.556 15 4 9 4 272 29.8 5.76 4 3 5 4 405358.0156 3876055.063 3889675.563 2 4 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus DNA binding;protein binding Pf01145 18673 ENSMUSG00000038845.11 Phb 11 RAF activation; Interleukin-20 family signaling; Processing of SMDT1 0 High Q9DB77 "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus OX=10090 GN=Uqcrc2 PE=1 SV=1" 0 17.425 16 6 9 6 453 48.2 9.25 1 6 2 1 6 2 1443383.645 4217259.219 3969306.5 5 6 6 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00675, Pf05193" 67003 ENSMUSG00000030884.12 Uqcrc2 7 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q91VR5 ATP-dependent RNA helicase DDX1 OS=Mus musculus OX=10090 GN=Ddx1 PE=1 SV=1 0 21.406 12 7 8 7 740 82.4 7.21 4 4 4 4 400285.1875 2629729.188 3296829 2 4 2 development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00622" 104721 ENSMUSG00000037149.9 Ddx1 12 0 Medium Q6P5H2 Nestin OS=Mus musculus OX=10090 GN=Nes PE=1 SV=1 0.028 1.781 0 1 8 1 1864 207 4.34 1 1 1 3 3 2 18752828 18192526 11440787 1 1 1 cell organization and biogenesis;cell proliferation;development;regulation of biological process cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf00038, Pf02463" 18008 ENSMUSG00000004891.16 Nes 3 0 High Q9WUB3 "Glycogen phosphorylase, muscle form OS=Mus musculus OX=10090 GN=Pygm PE=1 SV=3" 0 20.283 13 8 8 5 842 97.2 7.11 1 7 1 7 309178.875 961629.5625 1 1 cellular homeostasis;metabolic process;response to stimulus cytoplasm;endoplasmic reticulum catalytic activity;nucleotide binding Pf00343 19309 ENSMUSG00000032648.14; ENSMUSG00000106877.3 Pygm 19; CHR_MG4249_PATCH Glycogen breakdown (glycogenolysis) Insulin signaling pathway; Metabolic pathways; Insulin resistance; Starch and sucrose metabolism; Glucagon signaling pathway 0 High F8WJG3 Transformer-2 protein homolog beta OS=Mus musculus OX=10090 GN=Tra2b PE=1 SV=1 0 12.91 18 3 8 3 188 21.9 10.15 3 2 4 4 773073.0781 9663523.281 13315330.75 2 3 3 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 20462 ENSMUSG00000022858.15 Tra2b 16 0 High Q8R0Z2 Ecto-NOX disulfide-thiol exchanger 2 OS=Mus musculus OX=10090 GN=Enox2 PE=2 SV=1 0 19.798 13 5 8 5 598 68.2 5.92 4 3 4 4 8611093.75 16148714.13 5 4 metabolic process;regulation of biological process;transport extracellular;membrane catalytic activity "Pf00076, Pf05172, Pf14259" 209224 ENSMUSG00000031109.16 Enox2 X 0 High Q9ERU9 E3 SUMO-protein ligase RanBP2 OS=Mus musculus OX=10090 GN=Ranbp2 PE=1 SV=2 0 15.727 3 7 8 7 3053 340.9 6.18 1 4 3 1 4 3 1560683.172 4647067.688 4004391.125 4 6 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;metal ion binding;protein binding;RNA binding "Pf00160, Pf00515, Pf00638, Pf00641, Pf07719, Pf12185, Pf13414, Pf13432" 19386 ENSMUSG00000003226.7 Ranbp2 10 Transcriptional regulation by small RNAs; SUMOylation of RNA binding proteins; snRNP Assembly; SUMOylation of chromatin organization proteins; Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; RHO GTPases Activate Formins; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins; SUMOylation of DNA replication proteins RNA transport 0 High D3YUM1 "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus OX=10090 GN=Ndufv1 PE=1 SV=1" 0 18.756 19 7 8 7 455 49.9 8.07 3 2 3 3 2 3 1846309.828 3030783.875 3174940.063 4 4 3 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf01512, Pf10531, Pf10589" ENSMUSG00000037916.13 19 0 High Q02013 Aquaporin-1 OS=Mus musculus OX=10090 GN=Aqp1 PE=1 SV=3 0 18.19 11 2 8 2 269 28.8 7.43 2 2 2 2 3 3 13325759.13 12895990 16445836.75 2 2 2 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus protein binding;transporter activity Pf00230 11826 ENSMUSG00000004655.5 Aqp1 6 Erythrocytes take up carbon dioxide and release oxygen; Vasopressin regulates renal water homeostasis via Aquaporins; Passive transport by Aquaporins; Erythrocytes take up oxygen and release carbon dioxide Proximal tubule bicarbonate reclamation; Bile secretion; Renin secretion 0 High Q9DCT2 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs3 PE=1 SV=2" 0 10.569 21 4 8 4 263 30.1 7.17 1 4 2 1 4 3 1129110.531 3709328.953 2733671 3 4 2 metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity Pf00329 68349 ENSMUSG00000005510.9; ENSMUSG00000111727.1 Ndufs3 2; CHR_MG191_PATCH Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q6ZWZ4 60S ribosomal protein L36 OS=Mus musculus OX=10090 GN=Rpl36 PE=1 SV=1 0 8.679 30 3 8 3 105 12.2 11.59 1 2 3 1 3 4 5666828.813 13231777 18240160.5 3 3 3 metabolic process ribosome RNA binding;structural molecule activity Pf01158 54217 ENSMUSG00000057863.5 Rpl36 17 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q60902 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus OX=10090 GN=Eps15l1 PE=1 SV=3 0 20.384 8 6 8 6 907 99.2 5.02 1 5 2 1 5 2 1682915.641 4894596.938 3383121.125 5 5 4 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi;membrane;nucleus catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00261, Pf00529, Pf00769, Pf01496, Pf01576, Pf02321, Pf02463, Pf02841, Pf02994, Pf03148, Pf03938, Pf03962, Pf03999, Pf04012, Pf04111, Pf04156, Pf04778, Pf04912, Pf05103, Pf05149, Pf05478, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf06008, Pf06160, Pf06818, Pf07111, Pf07798, Pf07888, Pf07926, Pf08317, Pf08614, Pf09311, Pf09726, Pf09730, Pf09731, Pf09755, Pf10146, Pf10168, Pf10174, Pf10186, Pf10234, Pf10359, Pf10498, Pf11180, Pf11559, Pf11932, Pf12128, Pf12325, Pf12329, Pf12685, Pf12718, Pf12763, Pf12795, Pf13094, Pf13166, Pf13514, Pf13851, Pf13863, Pf13868, Pf13870, Pf13949, Pf14073, Pf14362, Pf14662, Pf14817, Pf14915, Pf14932, Pf14992, Pf15070, Pf15112, Pf15175, Pf15346, Pf15397, Pf15619" 13859 ENSMUSG00000006276.10 Eps15l1 8 Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation Endocytosis 0 High Q00623 Apolipoprotein A-I OS=Mus musculus OX=10090 GN=Apoa1 PE=1 SV=2 0 17.502 22 6 8 6 264 30.6 5.73 3 3 2 3 3 2 4344481 7343989.781 4979588.625 5 5 4 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;extracellular;nucleus enzyme regulator activity;protein binding;transporter activity Pf01442 11806 ENSMUSG00000032083.8 Apoa1 9 Post-translational protein phosphorylation; Scavenging by Class A Receptors; Chylomicron assembly; Signaling by GPCR; ABC transporters in lipid homeostasis; HDL clearance; Chylomicron remodeling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging by Class B Receptors; HDL assembly; Retinoid metabolism and transport; Platelet degranulation ; HDL remodeling; Scavenging of heme from plasma Vitamin digestion and absorption; PPAR signaling pathway; African trypanosomiasis; Fat digestion and absorption 0 High O35326 Serine/arginine-rich splicing factor 5 OS=Mus musculus OX=10090 GN=Srsf5 PE=1 SV=2 0 16.287 17 4 8 3 269 30.9 11.56 1 3 3 1 4 3 4370215.813 7145500.375 5761145.688 3 3 3 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 20384 ENSMUSG00000021134.17 Srsf5 12 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High Q9CZ19 Myosin light chain 4 OS=Mus musculus OX=10090 GN=Myl4 PE=1 SV=1 0 18.097 48 6 8 6 193 21.2 5.03 1 1 6 1 1 6 870947.3906 2633773.656 9724904.25 3 4 5 regulation of biological process metal ion binding;protein binding Pf13499 17896 ENSMUSG00000061086.12 Myl4 11 Striated Muscle Contraction Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes 0 High P97315 Cysteine and glycine-rich protein 1 OS=Mus musculus OX=10090 GN=Csrp1 PE=1 SV=3 0 22.434 26 3 8 3 193 20.6 8.57 1 2 3 1 2 5 3783064.438 8875243.25 15682083 3 3 3 cell organization and biogenesis cytoskeleton;nucleus metal ion binding;protein binding;RNA binding Pf00412 13007 ENSMUSG00000026421.14 Csrp1 1 0 High O89023 Tripeptidyl-peptidase 1 OS=Mus musculus OX=10090 GN=Tpp1 PE=1 SV=2 0 22.11 13 3 8 3 562 61.3 6.57 1 1 3 1 2 5 318653.1875 9175711.031 9596015.063 1 3 3 cell differentiation;cell organization and biogenesis;metabolic process mitochondrion;vacuole catalytic activity;metal ion binding;protein binding "Pf00082, Pf09286" 12751 ENSMUSG00000030894.5 Tpp1 7 Lysosome 0 High P62320 Small nuclear ribonucleoprotein Sm D3 OS=Mus musculus OX=10090 GN=Snrpd3 PE=1 SV=1 0 16.995 25 2 8 2 126 13.9 10.32 2 2 4 4 2924541.938 14947505 18631104 2 2 2 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 67332 ENSMUSG00000020180.10 Snrpd3 10 mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; mRNA Splicing - Major Pathway; snRNP Assembly; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs Spliceosome; Systemic lupus erythematosus 0 High Q6ZWY3 40S ribosomal protein S27-like OS=Mus musculus OX=10090 GN=Rps27l PE=1 SV=3 0 11.186 39 4 8 2 84 9.5 9.45 1 2 4 1 2 5 5240453.063 9362611.875 10726167.5 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;ribosome enzyme regulator activity;metal ion binding;RNA binding;structural molecule activity;translation regulator activity Pf01667 67941 ENSMUSG00000036781.13 Rps27l 9 2 High P01869 "Ig gamma-1 chain C region, membrane-bound form OS=Mus musculus OX=10090 GN=Ighg1 PE=1 SV=2" 0 12.919 11 3 8 1 393 43.4 6.44 1 2 3 1 3 4 769617.6875 1868560.625 2070877.5 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus membrane protein binding "Pf07654, Pf08205" 16017 Ighg1 12 0 High A0A0B4J1K5 Immunoglobulin lambda variable 3 (Fragment) OS=Mus musculus OX=10090 GN=Iglv3 PE=4 SV=1 0.003 3.273 8 1 8 1 122 13.4 5.76 1 1 4 4 3155753.75 61704814.67 55617465.06 1 1 1 response to stimulus "Pf07679, Pf07686" 404743 ENSMUSG00000076939.2 Iglv3; LOC102641542 16 0 High P70441 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Mus musculus OX=10090 GN=Slc9a3r1 PE=1 SV=3 0 17.193 23 6 8 6 355 38.6 5.9 4 4 4 4 450135.25 3691138.875 4251024.375 2 4 3 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;membrane protein binding;structural molecule activity "Pf00595, Pf09007, Pf13180" 26941 ENSMUSG00000020733.3 Slc9a3r1 11 0 High Q91VT8 Small integral membrane protein 14 OS=Mus musculus OX=10090 GN=Smim14 PE=1 SV=1 0 13.125 57 3 8 3 99 10.7 5.73 2 3 4 4 9350343.375 11207934.25 3 3 Met-loss+Acetyl [N-Term] endoplasmic reticulum;membrane Pf11027 68552 ENSMUSG00000037822.12 1110003E01Rik; Smim14 5 0 High A0A0U1RNL7 Protein-serine/threonine kinase OS=Mus musculus OX=10090 GN=Bckdk PE=1 SV=1 0 11.441 21 5 8 4 335 38 9.42 2 2 4 2 2 4 1771237.496 3291844.781 4585081.781 4 4 4 metabolic process mitochondrion catalytic activity Pf10436 ENSMUSG00000030802.14 7 1 High Q9DBG6 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Mus musculus OX=10090 GN=Rpn2 PE=1 SV=1 0 22.635 17 5 8 5 631 69 5.81 3 5 3 5 509700.8594 2687188.563 3404552.031 2 4 5 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf05817 20014 ENSMUSG00000027642.15 Rpn2 2 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High Q921H8 "3-ketoacyl-CoA thiolase A, peroxisomal OS=Mus musculus OX=10090 GN=Acaa1a PE=1 SV=1" 0 19.303 14 4 8 1 424 43.9 8.44 3 4 3 5 308880.5938 695844.625 1 1 metabolic process membrane;mitochondrion catalytic activity "Pf00108, Pf02803, Pf08541" 113868 ENSMUSG00000036138.16 Acaa1a 9 Beta-oxidation of very long chain fatty acids; Neutrophil degranulation; alpha-linolenic acid (ALA) metabolism "PPAR signaling pathway; Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; alpha-Linolenic acid metabolism; Biosynthesis of unsaturated fatty acids; Peroxisome" 0 High Q8BHD8 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pcmtd2 PE=2 SV=1 0 17.498 18 5 8 5 359 40.7 6.46 2 2 3 2 2 4 1430093.469 3241552.938 4059754.875 3 3 3 metabolic process cytoplasm catalytic activity "Pf01135, Pf12847, Pf13847" 245867 ENSMUSG00000027589.14 Pcmtd2 2 0 High P62317 Small nuclear ribonucleoprotein Sm D2 OS=Mus musculus OX=10090 GN=Snrpd2 PE=1 SV=1 0 9.758 32 3 8 3 118 13.5 9.91 1 2 3 1 4 3 575468 4879125.5 10968856.88 1 2 3 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex RNA binding Pf01423 107686 ENSMUSG00000040824.3 Snrpd2 7 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly Spliceosome 0 High Q3TPA4 Cadherin-16 OS=Mus musculus OX=10090 GN=Cdh16 PE=1 SV=1 0 12.377 9 4 8 4 800 86.5 4.68 3 3 3 5 337266.4063 3769315.313 6222682.75 1 3 4 cell communication membrane metal ion binding Pf00028 12556 ENSMUSG00000031881.6 Cdh16 8 0 High Q8VED5 "Keratin, type II cytoskeletal 79 OS=Mus musculus OX=10090 GN=Krt79 PE=1 SV=2" 0 10.932 6 3 8 1 531 57.5 7.69 3 2 3 3 2 3 30902334 5766922 7719672.5 1 1 1 catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf13166" 223917 ENSMUSG00000061397.7 Krt79 15 Formation of the cornified envelope 0 High E9PV44 ATPase inhibitory factor 1 OS=Mus musculus OX=10090 GN=Atpif1 PE=1 SV=1 0 12.806 28 4 8 4 74 8.8 9.31 4 1 2 5 1 2 32895565.5 24944211.25 14142844.5 4 4 3 cell differentiation;metabolic process;regulation of biological process mitochondrion enzyme regulator activity Pf04568 ENSMUSG00000054428.12 4 0 High Q497I4 "Keratin, type I cuticular Ha5 OS=Mus musculus OX=10090 GN=Krt35 PE=1 SV=1" 0.003 3.425 3 2 8 1 455 50.5 4.97 1 1 2 3 2 3 811198.875 1626311.875 3767834 1 1 1 structural molecule activity Pf00038 53617 ENSMUSG00000048013.9 Krt35 11 Formation of the cornified envelope 0 High Q9EP71 Ankycorbin OS=Mus musculus OX=10090 GN=Rai14 PE=1 SV=1 0 23.754 7 5 8 5 979 108.8 6.27 1 3 3 2 3 3 1364868.781 4433055.719 7762158.125 3 5 5 cell differentiation;cell organization and biogenesis;transport cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding "Pf00023, Pf00529, Pf01576, Pf03961, Pf05667, Pf05701, Pf12128, Pf12796, Pf13166, Pf13514, Pf13606, Pf13637, Pf13857, Pf14817" 75646 ENSMUSG00000022246.13 Rai14 15 0 High E9QQ10 A-kinase anchor protein 9 OS=Mus musculus OX=10090 GN=Akap9 PE=1 SV=1 0 14.437 1 5 8 5 3779 433.9 5.03 1 4 2 2 4 2 28613665.94 137714519.9 310402956.8 2 3 3 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;Golgi protein binding;structural molecule activity "Pf05852, Pf10495, Pf12128, Pf13166" 100986 ENSMUSG00000040407.17 Akap9 5 "Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; CREB phosphorylation through the activation of CaMKII; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Ras activation uopn Ca2+ infux through NMDA receptor; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Unblocking of NMDA receptor, glutamate binding and activation; Interleukin-20 family signaling; RAF/MAP kinase cascade; Phase 2 - plateau phase; Phase 3 - rapid repolarisation" 0 High P62911 60S ribosomal protein L32 OS=Mus musculus OX=10090 GN=Rpl32 PE=1 SV=2 0 21.398 27 3 8 3 135 15.9 11.33 2 1 3 2 1 5 2217303.164 10267080.25 13476079.38 2 3 4 metabolic process;response to stimulus membrane;ribosome RNA binding;structural molecule activity Pf01655 19951; 652989 ENSMUSG00000057841.5 Rpl32; Rpl32p 6; X L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62141 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Mus musculus OX=10090 GN=Ppp1cb PE=1 SV=3 0 15.776 17 4 8 1 327 37.2 6.19 2 4 2 2 4 2 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;metal ion binding;protein binding Pf00149 19046 ENSMUSG00000014956.15 Ppp1cb 5 RHO GTPases activate PAKs; Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate PKNs Oxytocin signaling pathway; mRNA surveillance pathway; Herpes simplex infection; Regulation of actin cytoskeleton; Dopaminergic synapse; Focal adhesion; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Hippo signaling pathway; Platelet activation; Insulin resistance; Oocyte meiosis; Proteoglycans in cancer; cGMP-PKG signaling pathway; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 0 High Q91YL3 Uridine-cytidine kinase-like 1 OS=Mus musculus OX=10090 GN=Uckl1 PE=1 SV=1 0 13.536 12 4 8 4 548 60.8 7.15 1 2 4 1 2 5 596730.75 1669213.688 1741849.125 1 2 2 metabolic process cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;nucleotide binding "Pf00485, Pf07931, Pf13207, Pf14681" 68556 ENSMUSG00000089917.7 Uckl1 2 Pyrimidine salvage Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High P61982 14-3-3 protein gamma OS=Mus musculus OX=10090 GN=Ywhag PE=1 SV=2 0 26.989 30 5 8 3 247 28.3 4.89 2 4 2 6 1190612.953 2912834.313 2 3 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;protein binding;RNA binding Pf00244 22628 ENSMUSG00000051391.9 Ywhag 5 Translocation of GLUT4 to the plasma membrane; Anchoring of the basal body to the plasma membrane; Activation of BAD and translocation to mitochondria ; AURKA Activation by TPX2; RHO GTPases activate PKNs; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High Q99LF4 RNA-splicing ligase RtcB homolog OS=Mus musculus OX=10090 GN=Rtcb PE=1 SV=1 0 24.108 19 6 8 6 505 55.2 7.23 4 3 4 4 4979267.375 13340095.63 31399408.69 4 6 6 metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf01139 28088 ENSMUSG00000001783.3 D10Wsu52e; Rtcb 10 0 High E9PYD9 Folate receptor alpha (Fragment) OS=Mus musculus OX=10090 GN=Folr1 PE=1 SV=1 0 9.538 20 2 8 2 137 16 6.83 2 1 2 2 2 4 1935752.25 5430940.625 7659752.625 2 2 2 transport transporter activity Pf03024 ENSMUSG00000001827.12 7 0 High Q7TMK6 Protein Hook homolog 2 OS=Mus musculus OX=10090 GN=Hook2 PE=1 SV=3 0 25.084 11 6 8 6 716 83.3 5.43 4 4 4 4 1786509.25 4065132.469 4101138.719 2 4 4 cell organization and biogenesis;transport cytoplasm;cytoskeleton;cytosol protein binding Pf05622 170833 ENSMUSG00000052566.8 Hook2 8 0 High Q9Z2X1 Heterogeneous nuclear ribonucleoprotein F OS=Mus musculus OX=10090 GN=Hnrnpf PE=1 SV=3 0 11.748 11 3 8 3 415 45.7 5.49 2 3 2 2 4 2 1962399.219 7331914.063 8223106.188 3 3 3 metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 98758 ENSMUSG00000042079.13 Hnrnpf 6 mRNA Splicing - Major Pathway; FGFR2 alternative splicing 0 High O08749 "Dihydrolipoyl dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Dld PE=1 SV=2" 0 8.596 10 4 8 4 509 54.2 7.9 3 1 2 5 1 2 3418990.344 4063466.25 3903406.563 4 4 3 cellular homeostasis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00070, Pf00890, Pf01134, Pf01946, Pf02852, Pf03486, Pf07992, Pf12831, Pf13450" 13382 ENSMUSG00000020664.10 Dld 12 Glycine degradation; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Branched-chain amino acid catabolism "Pyruvate metabolism; Citrate cycle (TCA cycle); Valine, leucine and isoleucine degradation; Metabolic pathways; Glycine, serine and threonine metabolism; Glycolysis / Gluconeogenesis; Propanoate metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High Q62189 U1 small nuclear ribonucleoprotein A OS=Mus musculus OX=10090 GN=Snrpa PE=1 SV=3 0 9.869 15 4 8 4 287 31.8 9.8 1 4 2 1 5 2 582197.625 3856372.938 2776454.75 4 4 3 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 53607 ENSMUSG00000061479.15 Snrpa 7 mRNA Splicing - Major Pathway Spliceosome 0 High Q9CZ13 "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Mus musculus OX=10090 GN=Uqcrc1 PE=1 SV=2" 0 21.436 19 6 8 6 480 52.8 6.21 2 3 3 2 3 3 1509919.688 3458865.125 4597936 3 4 3 metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00675, Pf05193, Pf08367" 22273 ENSMUSG00000025651.14; ENSMUSG00000107235.3 Uqcrc1 9; CHR_MG117_PATCH Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P68510 14-3-3 protein eta OS=Mus musculus OX=10090 GN=Ywhah PE=1 SV=2 0 19.487 30 5 8 3 246 28.2 4.89 3 4 3 5 429745.4375 2945123.063 3303469.938 1 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane protein binding Pf00244 22629 ENSMUSG00000018965.11 Ywhah 5 Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High Q8BI08 Protein MAL2 OS=Mus musculus OX=10090 GN=Mal2 PE=1 SV=1 0 9.352 18 2 8 2 175 19.1 6.49 1 2 1 2 3 3 588535.1875 3322349.188 4590992.125 1 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;transport membrane structural molecule activity Pf01284 105853 ENSMUSG00000024479.2 Mal2 15 0 High O55142 60S ribosomal protein L35a OS=Mus musculus OX=10090 GN=Rpl35a PE=1 SV=2 0 10.79 27 3 8 3 110 12.5 10.89 1 2 3 1 3 4 7082712.938 16733724.25 14512734.25 3 3 3 metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf01247 100043423; 57808; 100042363; 100302576; 100040169; 100046034; 100048620 ENSMUSG00000060636.13 Rpl35a-ps4; Rpl35a; Rpl35a-ps2; Gm10243; Rpl35a-ps5; LOC100862595; Gm14279; LOC100048620 2; 16; 1; 6; 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P55302 Alpha-2-macroglobulin receptor-associated protein OS=Mus musculus OX=10090 GN=Lrpap1 PE=1 SV=1 0 15.065 18 4 8 4 360 42.2 7.87 1 2 3 1 3 4 547118.5938 2588152.438 4026329.063 2 3 3 regulation of biological process;transport cell surface;cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;organelle lumen protein binding "Pf06400, Pf06401" 16976 ENSMUSG00000029103.16 Lrpap1 5 0 High Q923I7 Sodium/glucose cotransporter 2 OS=Mus musculus OX=10090 GN=Slc5a2 PE=1 SV=1 0 27.962 11 5 8 5 670 73 7.66 1 2 4 1 3 4 1485552.969 21629447.75 32204656.63 2 5 5 Acetyl [N-Term] transport membrane protein binding;transporter activity Pf00474 246787 ENSMUSG00000030781.13 Slc5a2 7 Cellular hexose transport 0 High E9PWY9 Phenylalanine--tRNA ligase alpha subunit OS=Mus musculus OX=10090 GN=Farsa PE=1 SV=1 0 14.912 24 6 7 6 507 57.4 8.02 2 5 2 5 387452.6641 2079095.438 4527637.875 2 4 4 Met-loss+Acetyl [N-Term] metabolic process cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00152, Pf01409, Pf08279" ENSMUSG00000003808.18 8 0 High Q8JZN5 "Complex I assembly factor ACAD9, mitochondrial OS=Mus musculus OX=10090 GN=Acad9 PE=1 SV=2" 0 20.087 11 5 7 5 625 68.7 7.46 3 4 3 4 394596.7188 2374127.594 4194512.5 2 4 4 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 229211 ENSMUSG00000027710.14 Acad9 3 Complex I biogenesis 0 High Q01768 Nucleoside diphosphate kinase B OS=Mus musculus OX=10090 GN=Nme2 PE=1 SV=1 0 11.149 32 4 7 4 152 17.4 7.5 3 2 4 3 802005.5938 3974560.844 4004166.25 3 4 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00334 18103 ENSMUSG00000020857.11 Nme2 11 Interconversion of nucleotide di- and triphosphates; Neutrophil degranulation Metabolic pathways; Purine metabolism; Pyrimidine metabolism 0 High O88986 "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Mus musculus OX=10090 GN=Gcat PE=1 SV=2" 0 25.43 25 5 7 5 416 44.9 7.33 1 1 5 1 1 5 1888022.188 5954942.109 8382417.5 3 4 4 metabolic process membrane;mitochondrion;nucleus catalytic activity "Pf00155, Pf00266, Pf00464" 26912 ENSMUSG00000006378.13 Gcat 15 "Glycine, serine and threonine metabolism" 0 High P07744 "Keratin, type II cytoskeletal 4 OS=Mus musculus OX=10090 GN=Krt4 PE=1 SV=2" 0 8.707 5 4 7 1 525 56.2 8.15 3 2 5 2 188903.1563 1 cell differentiation;cell organization and biogenesis;regulation of biological process cell surface;cytoskeleton;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576" 16682 ENSMUSG00000059668.5 Krt4 15 Formation of the cornified envelope 0 High P58137 Acyl-coenzyme A thioesterase 8 OS=Mus musculus OX=10090 GN=Acot8 PE=1 SV=1 0 20.891 19 5 7 5 320 35.8 7.64 1 1 4 1 1 5 2649009.5 3469662.875 9103109.313 4 4 4 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;mitochondrion;organelle lumen catalytic activity;protein binding "Pf02551, Pf13622" 170789 ENSMUSG00000017307.15 Acot8 2 Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism Metabolic pathways; Primary bile acid biosynthesis; Peroxisome 0 High O35295 Transcriptional activator protein Pur-beta OS=Mus musculus OX=10090 GN=Purb PE=1 SV=3 0 11.522 12 4 7 2 324 33.9 5.43 1 2 3 1 3 3 1321085.781 2951307.813 3086696.25 2 2 1 cell death;cell differentiation;cell proliferation;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding;translation regulator activity Pf04845 19291 ENSMUSG00000094483.2 Purb 11 0 High G3UWY3 Protein cordon-bleu OS=Mus musculus OX=10090 GN=Cobl PE=1 SV=1 0 15.205 3 3 7 3 1330 143.2 7.39 2 2 2 5 1488359.172 6765955.531 6382437.938 3 3 2 cell growth;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding Pf09469 12808 ENSMUSG00000020173.17 Cobl 11 0 High Q3TW96 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Mus musculus OX=10090 GN=Uap1l1 PE=1 SV=1 0 16.873 14 6 7 6 507 56.6 5.43 2 5 2 5 252600.9375 4326615.688 5857214.563 2 4 6 metabolic process cytosol catalytic activity "Pf01704, Pf12804" 227620 ENSMUSG00000026956.15 Uap1l1 2 Metabolic pathways; Amino sugar and nucleotide sugar metabolism 0 High A0A2I3BRT4 Epiplakin OS=Mus musculus OX=10090 GN=Eppk1 PE=1 SV=1 0 18.258 5 5 7 2 3458 381.5 5.92 4 2 5 2 234283.7031 653929.5 2079762.25 1 1 2 0 High Q921W0 Charged multivesicular body protein 1a OS=Mus musculus OX=10090 GN=Chmp1a PE=1 SV=1 0 5.486 13 3 7 3 196 21.6 8.06 2 2 3 2 2 3 2688226.438 8012133.125 12768434.75 3 3 3 cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;endosome;membrane;nucleus protein binding Pf03357 234852 ENSMUSG00000000743.9 Chmp1a 8 Endocytosis 0 High A0A0A6YWR2 Ig gamma-1 chain C region secreted form (Fragment) OS=Mus musculus OX=10090 GN=Ighg1 PE=1 SV=1 0 10.479 11 3 7 1 393 43.4 6.44 1 2 2 1 3 3 4432203.5 3516016.75 5708748.75 1 1 2 membrane "Pf07654, Pf08205" ENSMUSG00000076614.7 12 Regulation of Complement cascade; Role of phospholipids in phagocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR activation; Classical antibody-mediated complement activation 2 High A2AUK7 Band 4.1-like protein 1 OS=Mus musculus OX=10090 GN=Epb41l1 PE=1 SV=1 0 18.678 9 6 7 5 730 81.8 6.67 1 1 4 1 1 5 932033.5781 4268520.313 7076775.25 3 4 4 cell organization and biogenesis cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" 13821 ENSMUSG00000027624.17 Epb4.1l1; Epb41l1 2 Trafficking of AMPA receptors 0 High Q68FL4 Putative adenosylhomocysteinase 3 OS=Mus musculus OX=10090 GN=Ahcyl2 PE=1 SV=1 0 13.463 9 5 7 2 613 66.9 7.36 2 2 3 2 2 3 2381580.438 3936479.031 7629020.75 5 5 5 metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum catalytic activity;nucleotide binding "Pf00670, Pf01262, Pf02254, Pf02826, Pf05221" 74340 ENSMUSG00000029772.17 Ahcyl2 6 Bicarbonate transporters Metabolic pathways; Cysteine and methionine metabolism 3 High A0A140T8M0 Immunoglobulin kappa variable 1-117 (Fragment) OS=Mus musculus OX=10090 GN=Igkv1-117 PE=4 SV=2 0 8.657 33 2 7 2 119 13.1 8.48 1 2 2 2 2 3 2886099.781 3893664.063 5679307.75 2 2 2 "Pf07679, Pf07686" 16098 ENSMUSG00000094335.2 Igkv1-117 6 0 High Q62376 U1 small nuclear ribonucleoprotein 70 kDa OS=Mus musculus OX=10090 GN=Snrnp70 PE=1 SV=2 0 12.616 12 5 7 5 448 52 9.94 3 3 3 4 507738.9219 4219245.313 4884655.438 2 4 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;spliceosomal complex RNA binding "Pf00076, Pf12220, Pf13893, Pf14259" 20637 ENSMUSG00000063511.11 Snrnp70 7 mRNA Splicing - Major Pathway Spliceosome 0 High Q8BMC1 V-type proton ATPase subunit G 3 OS=Mus musculus OX=10090 GN=Atp6v1g3 PE=1 SV=1 0 19.034 47 4 7 4 118 13.7 8.97 1 4 1 1 5 1 895023.875 5564130.625 6404582.063 2 3 2 transport cytosol;membrane catalytic activity;protein binding;transporter activity Pf03179 338375 ENSMUSG00000026394.5 Atp6v1g3 1 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High Q3TLP8 Ras-related C3 botulinum toxin substrate 1 OS=Mus musculus OX=10090 GN=Rac1 PE=1 SV=1 0 11.909 16 4 7 4 211 23.4 8.69 1 2 4 1 2 4 1682673.375 5145013.438 7667332.063 2 4 4 cell communication;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf08477" 19353 ENSMUSG00000001847.14 Rac1 5 0 High B1AV77 Aldehyde dehydrogenase OS=Mus musculus OX=10090 GN=Aldh3a2 PE=1 SV=1 0 14.683 11 4 7 4 487 54.3 8.48 3 3 3 4 145760.6094 1180619.625 2373970.938 1 2 3 metabolic process;response to stimulus cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus catalytic activity Pf00171 11671 ENSMUSG00000010025.19 Aldh3a2 11 0 High G3UYV7 40S ribosomal protein S28 (Fragment) OS=Mus musculus OX=10090 GN=Rps28 PE=1 SV=1 0 14.375 57 3 7 3 56 6.3 9.96 1 3 3 1 3 3 4980245.875 14482133.25 15199032 3 3 3 metabolic process ribosome structural molecule activity Pf01200 ENSMUSG00000067288.12 17 0 High Q3TDD9 Protein phosphatase 1 regulatory subunit 21 OS=Mus musculus OX=10090 GN=Ppp1r21 PE=1 SV=2 0 21.3 9 5 7 5 780 88.3 6.9 5 2 5 2 3534881.688 3403758.094 4 4 membrane protein binding "Pf10205, Pf10212" 73825 ENSMUSG00000034709.8 Klraq1; Ppp1r21 17 0 High G3UX26 Voltage-dependent anion-selective channel protein 2 OS=Mus musculus OX=10090 GN=Vdac2 PE=1 SV=1 0 14.334 21 5 7 5 283 30.4 7.58 1 3 3 1 3 3 2814521 5660370.25 4857845.813 3 4 4 transport membrane transporter activity Pf01459 ENSMUSG00000021771.13 14 0 Medium Q9CQA8 Centrosomal protein of 19 kDa OS=Mus musculus OX=10090 GN=Cep19 PE=2 SV=1 0.029 1.67 10 1 7 1 163 19.2 5.53 1 1 1 1 4 2 4107198.125 19342001.75 32749882 1 1 1 cell organization and biogenesis cytoplasm;cytoskeleton Pf14933 66994 ENSMUSG00000035790.15 Cep19 16 0 High A0A1B0GRU8 Pre-mRNA-processing factor 40 homolog A OS=Mus musculus OX=10090 GN=Prpf40a PE=1 SV=1 0 12.293 6 5 7 5 926 105.5 7.99 1 4 1 2 4 1 20542865.38 27984135.19 18439881.5 5 4 3 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00397, Pf01846" 56194 ENSMUSG00000061136.14 Prpf40a 2 0 High P29341 Polyadenylate-binding protein 1 OS=Mus musculus OX=10090 GN=Pabpc1 PE=1 SV=2 0 17.497 11 6 7 6 636 70.6 9.5 1 3 3 1 3 3 1043435.469 4227469.938 5655461.5 3 5 5 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf00658, Pf13893, Pf14259" 18458 ENSMUSG00000022283.14 Pabpc1 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Translation initiation complex formation; Deadenylation of mRNA mRNA surveillance pathway; RNA degradation; RNA transport 0 High P42669 Transcriptional activator protein Pur-alpha OS=Mus musculus OX=10090 GN=Pura PE=1 SV=1 0 13.404 15 5 7 3 321 34.9 6.44 1 2 4 1 2 4 1532434.375 5442970.75 6779550.375 2 3 4 cell death;cell differentiation;cell proliferation;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding;translation regulator activity Pf04845 19290 ENSMUSG00000043991.4 Pura 18 2 High P15331 Peripherin OS=Mus musculus OX=10090 GN=Prph PE=1 SV=2 0 11.769 8 4 7 1 475 54.2 5.52 3 3 4 3 294870.5313 634577.6875 1 1 cell organization and biogenesis membrane protein binding;structural molecule activity "Pf00038, Pf04732" 19132 Prph 15 0 High O08677 Kininogen-1 OS=Mus musculus OX=10090 GN=Kng1 PE=1 SV=1 0 11.753 8 5 7 5 661 73.1 6.54 3 3 3 4 158802.3438 3471669.25 2543744.75 2 5 5 cellular homeostasis;coagulation;defense response;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding Pf00031 16644 Kng1 16 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; Intrinsic Pathway of Fibrin Clot Formation; G alpha (i) signalling events; Post-translational protein phosphorylation; Platelet degranulation ; Gastrin-CREB signalling pathway via PKC and MAPK Complement and coagulation cascades 0 High P62960 Y-box-binding protein 1 OS=Mus musculus OX=10090 GN=Ybx1 PE=1 SV=3 0 17.593 18 4 7 4 322 35.7 9.88 2 3 2 5 2507009.516 4674186.125 5777584.313 3 3 3 metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf00313 22608 ENSMUSG00000028639.14 Ybx1 4 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway 0 High Q8BKZ9 "Pyruvate dehydrogenase protein X component, mitochondrial OS=Mus musculus OX=10090 GN=Pdhx PE=1 SV=1" 0 8.648 7 3 7 3 501 54 7.75 2 3 2 2 3 2 2235873.75 2952416.813 3296721.813 3 3 3 metabolic process mitochondrion;organelle lumen catalytic activity "Pf00198, Pf00364, Pf02817" 27402 ENSMUSG00000010914.10 Pdhx 2 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Metabolic pathways 0 High Q9QWR8 Alpha-N-acetylgalactosaminidase OS=Mus musculus OX=10090 GN=Naga PE=1 SV=2 0 14.253 15 5 7 5 415 47.2 6.44 5 2 5 2 181227.0078 7716649 4829169.375 2 5 3 metabolic process cytoplasm;vacuole catalytic activity;protein binding Pf02065 17939 ENSMUSG00000022453.7 Naga 15 Glycosphingolipid biosynthesis - globo and isoglobo series; Lysosome 0 High Q99LC5 "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Etfa PE=1 SV=2" 0 14.504 16 4 7 4 333 35 8.38 4 2 4 3 516956.1563 3309840.438 5055137.25 1 4 3 metabolic process;transport mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00766, Pf01012" 110842 ENSMUSG00000032314.14 Etfa 9 Respiratory electron transport 0 High Q61391 Neprilysin OS=Mus musculus OX=10090 GN=Mme PE=1 SV=3 0 16.667 8 4 7 4 750 85.6 5.81 2 3 2 5 711833.2969 3923323.281 7596413.375 2 4 4 metabolic process;response to stimulus cytoplasm;membrane catalytic activity;metal ion binding "Pf01431, Pf05649" 17380 ENSMUSG00000027820.12 Mme 3 Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation Protein digestion and absorption; Renin-angiotensin system; Alzheimer's disease; Hematopoietic cell lineage 0 High Q61694 NADPH-dependent 3-keto-steroid reductase Hsd3b5 OS=Mus musculus OX=10090 GN=Hsd3b5 PE=1 SV=4 0 26.141 20 5 7 1 373 41.9 9.01 1 5 2 5 534296.3125 1751997.875 1 1 Met-loss [N-Term] metabolic process;response to stimulus endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding "Pf00106, Pf01073, Pf01370, Pf02719, Pf04321, Pf05368, Pf07993, Pf08659, Pf13460" 15496 ENSMUSG00000038092.6 Hsd3b5 3 Glucocorticoid biosynthesis; Androgen biosynthesis; Mineralocorticoid biosynthesis Steroid hormone biosynthesis; Ovarian steroidogenesis; Metabolic pathways; Aldosterone synthesis and secretion 0 High Q9DBT6 Tensin 1 OS=Mus musculus OX=10090 GN=Tns1 PE=1 SV=1 0 13.03 11 5 7 5 624 65.3 9.52 3 3 4 3 600679.875 4026772.25 4338084.75 2 4 3 cell organization and biogenesis;cellular component movement protein binding;RNA binding "Pf00017, Pf08416" 21961 ENSMUSG00000055322.15 Tns1 1 0 High P27641 X-ray repair cross-complementing protein 5 OS=Mus musculus OX=10090 GN=Xrcc5 PE=1 SV=4 0 12.674 10 5 7 5 732 83 5.16 3 4 3 4 420393.6406 1352034.734 1997015.219 3 3 4 cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf02735, Pf03730, Pf03731, Pf08785" 22596 ENSMUSG00000026187.8 Xrcc5 1 Neutrophil degranulation; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High E9QP62 LIM and senescent cell antigen-like-containing domain protein OS=Mus musculus OX=10090 GN=Lims1 PE=1 SV=1 0 8.1 8 3 7 3 387 44.3 7.88 2 2 1 2 3 2 2192779.188 5723398.688 13892717.75 3 3 3 cell organization and biogenesis;regulation of biological process;response to stimulus membrane metal ion binding;protein binding Pf00412 110829 ENSMUSG00000019920.17 Lims1 10 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 0 High A0A0G2JFX7 RNA-binding protein 8A OS=Mus musculus OX=10090 GN=Rbm8a PE=1 SV=1 0 11.396 27 4 7 4 171 19.1 4.97 3 2 3 4 278697.2344 10944606.38 14742773.25 2 4 4 metabolic process;transport cytoplasm;nucleus RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" ENSMUSG00000038374.10 3 0 High O55022 Membrane-associated progesterone receptor component 1 OS=Mus musculus OX=10090 GN=Pgrmc1 PE=1 SV=4 0 4.963 8 2 7 2 195 21.7 4.7 2 2 2 2 3 2 851391.75 2347969.188 2903151.875 2 2 2 regulation of biological process;response to stimulus endoplasmic reticulum;membrane Pf00173 53328 ENSMUSG00000006373.10 Pgrmc1 X Neutrophil degranulation 0 High P62843 40S ribosomal protein S15 OS=Mus musculus OX=10090 GN=Rps15 PE=1 SV=2 0 29.862 28 2 7 2 145 17 10.39 2 2 3 4 684225.6406 2865671.875 4838812.875 1 2 2 cell differentiation;cell organization and biogenesis;metabolic process;transport membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00203 20054 ENSMUSG00000063457.14 Rps15 10 Ribosome 0 High P54823 Probable ATP-dependent RNA helicase DDX6 OS=Mus musculus OX=10090 GN=Ddx6 PE=1 SV=1 0 13.305 15 5 6 5 483 54.2 8.66 1 1 4 1 1 4 656729.4453 1673046.656 3839599.938 3 3 4 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf14617" 13209 ENSMUSG00000032097.10 Ddx6 9 mRNA decay by 5' to 3' exoribonuclease RNA degradation 0 High Q791V5 Mitochondrial carrier homolog 2 OS=Mus musculus OX=10090 GN=Mtch2 PE=1 SV=1 0 7.303 10 3 6 3 303 33.5 8.25 1 2 3 1 2 3 679447 1949423.688 2490654.5 2 3 3 cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus Pf00153 56428 ENSMUSG00000027282.17; ENSMUSG00000111714.1 Mtch2 2; CHR_MG191_PATCH 0 High Q61555 Fibrillin-2 OS=Mus musculus OX=10090 GN=Fbn2 PE=1 SV=2 0 6.609 1 3 6 1 2907 313.6 4.84 1 2 2 1 2 3 638756.375 2040984.5 5257065 1 1 1 regulation of biological process cell surface;extracellular;membrane metal ion binding;protein binding;structural molecule activity "Pf00028, Pf00683, Pf06247, Pf07645, Pf12662, Pf12947, Pf14670" 14119 ENSMUSG00000024598.8 Fbn2 18 Molecules associated with elastic fibres; Degradation of the extracellular matrix 0 High A0A0R4J023 "Methylglutaconyl-CoA hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Auh PE=1 SV=1" 0 8.695 13 3 6 3 314 33.3 9.42 1 2 3 1 2 3 739479.6563 2252398.688 4077430.563 2 3 3 metabolic process mitochondrion catalytic activity;RNA binding Pf00378 11992 ENSMUSG00000021460.16 Auh 13 Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways" 0 High P40142 Transketolase OS=Mus musculus OX=10090 GN=Tkt PE=1 SV=1 0 13.819 6 3 6 3 623 67.6 7.5 3 2 3 3 305873.875 1778712.5 2079658.375 1 2 2 metabolic process;regulation of biological process membrane catalytic activity;metal ion binding;protein binding "Pf00456, Pf00676, Pf02779, Pf02780" 21881 ENSMUSG00000021957.6 Tkt 14 Pentose phosphate pathway (hexose monophosphate shunt); Insulin effects increased synthesis of Xylulose-5-Phosphate Metabolic pathways; Biosynthesis of amino acids; Pentose phosphate pathway; Carbon metabolism 0 High Q9R0N0 Galactokinase OS=Mus musculus OX=10090 GN=Galk1 PE=1 SV=2 0 13.96 19 4 6 4 392 42.3 5.26 2 4 2 4 947789 3722069.875 4622463.563 2 2 3 metabolic process cytoplasm;membrane catalytic activity;nucleotide binding;protein binding "Pf08544, Pf10509" 14635 ENSMUSG00000020766.4 Galk1 11 Galactose catabolism Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Galactose metabolism 0 High Q8BGH2 Sorting and assembly machinery component 50 homolog OS=Mus musculus OX=10090 GN=Samm50 PE=1 SV=1 0 21.258 11 4 6 4 469 51.8 6.8 2 3 2 4 1068234.594 2367801.719 2869139.563 2 3 3 cell organization and biogenesis;transport cytoplasm;membrane;mitochondrion protein binding "Pf01103, Pf07244" 68653 ENSMUSG00000022437.6 Samm50 15 0 High P47955 60S acidic ribosomal protein P1 OS=Mus musculus OX=10090 GN=Rplp1 PE=1 SV=1 0 20.792 67 3 6 3 114 11.5 4.32 2 2 3 3 241319.8281 3442478.063 8888288.156 1 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process ribosome enzyme regulator activity;structural molecule activity Pf00428 56040 ENSMUSG00000007892.8 Rplp1 9 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8BXK9 Chloride intracellular channel protein 5 OS=Mus musculus OX=10090 GN=Clic5 PE=1 SV=1 0 14.339 20 5 6 5 251 28.3 5.94 1 2 3 1 2 3 18898753.67 63285122.72 47673460.19 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;Golgi;membrane;nucleus catalytic activity;protein binding;transporter activity "Pf13409, Pf13410, Pf13417" 224796 ENSMUSG00000023959.8 Clic5 17 0 High F6RJV6 LanC-like protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Lancl2 PE=1 SV=1 0 19.661 16 4 6 4 441 49.7 7.14 1 1 3 1 1 4 320739.5625 464135.7813 1712491.75 1 1 2 Pf05147 ENSMUSG00000062190.12 6 0 High Q9Z204 Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Mus musculus OX=10090 GN=Hnrnpc PE=1 SV=1 0 14.174 21 6 6 6 313 34.4 5.05 1 2 3 1 2 3 4513519.563 4552987.125 4 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 15381 ENSMUSG00000060373.14 Hnrnpc 14 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Spliceosome 0 High Q9D883 Splicing factor U2AF 35 kDa subunit OS=Mus musculus OX=10090 GN=U2af1 PE=1 SV=4 0 15.658 18 4 6 4 239 27.8 8.81 1 4 1 1 4 1 759746.1875 5279712.813 5672339.125 2 4 3 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00076, Pf00642, Pf13893" 108121 ENSMUSG00000061613.12 U2af1 17 Spliceosome 0 High P46660 Alpha-internexin OS=Mus musculus OX=10090 GN=Ina PE=1 SV=3 0 4.864 4 2 6 1 501 55.3 5.4 1 2 1 2 2 2 517981.0938 1031621.188 1 1 cell differentiation;cell organization and biogenesis;development;regulation of biological process cytoskeleton;membrane protein binding;structural molecule activity "Pf00038, Pf04732, Pf10186" 226180 ENSMUSG00000034336.3 Ina 19 0 High P21614 Vitamin D-binding protein OS=Mus musculus OX=10090 GN=Gc PE=1 SV=2 0 19.816 11 3 6 3 476 53.6 5.5 2 3 3 3 176774.3438 2938876.688 3367818.563 2 3 3 metabolic process;transport cytosol;extracellular protein binding;transporter activity "Pf00273, Pf09164" 14473 ENSMUSG00000035540.12 Gc 5 Vitamin D (calciferol) metabolism 0 High Q9CQ65 S-methyl-5'-thioadenosine phosphorylase OS=Mus musculus OX=10090 GN=Mtap PE=1 SV=1 0 11.514 17 4 6 4 283 31 7.14 3 3 3 3 234981.5703 1783503.875 3414736 2 3 4 metabolic process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity Pf01048 66902 ENSMUSG00000062937.7 Mtap 4 Methionine salvage pathway Metabolic pathways; Cysteine and methionine metabolism 0 High Q9CQV8 14-3-3 protein beta/alpha OS=Mus musculus OX=10090 GN=Ywhab PE=1 SV=3 0 9.428 22 4 6 2 246 28.1 4.83 2 3 2 4 305609.7188 497336.6875 914755.125 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding Pf00244 54401 ENSMUSG00000018326.9 Ywhab 2 Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Rap1 signalling; RAF activation; Interleukin-20 family signaling; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; MAP2K and MAPK activation; Negative regulation of MAPK pathway; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by Hippo Epstein-Barr virus infection; Hippo signaling pathway; Hepatitis B; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High P63276 40S ribosomal protein S17 OS=Mus musculus OX=10090 GN=Rps17 PE=1 SV=2 0 14.629 33 4 6 4 135 15.5 9.85 2 2 1 3 2 1 5011079 10013108 6800560.875 2 2 2 cell organization and biogenesis;metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00833 20068 ENSMUSG00000061787.15 Rps17 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9JIL4 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 OS=Mus musculus OX=10090 GN=Pdzk1 PE=1 SV=1 0 19.046 14 5 6 5 519 56.5 5.43 3 3 3 3 197595.6094 2582003.5 5864344.063 1 3 5 cell organization and biogenesis;regulation of biological process;transport membrane protein binding "Pf00595, Pf13180" 59020 Pdzk1 3 0 High B1AZI6 THO complex subunit 2 OS=Mus musculus OX=10090 GN=Thoc2 PE=1 SV=1 0 15.107 5 5 6 5 1594 182.7 8.44 3 3 3 3 2654328.438 3947059.313 3 4 Met-loss+Acetyl [N-Term] cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport nucleus protein binding;RNA binding "Pf11262, Pf11732" 331401 ENSMUSG00000037475.15 Thoc2 X mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Spliceosome; RNA transport 0 High Q61081 Hsp90 co-chaperone Cdc37 OS=Mus musculus OX=10090 GN=Cdc37 PE=1 SV=1 0 9.835 12 4 6 4 379 44.6 5.34 3 3 3 3 226317.8359 2090303.75 1859570.813 2 3 2 metabolic process;regulation of biological process cytoplasm;cytosol catalytic activity;enzyme regulator activity;protein binding "Pf03234, Pf04111, Pf08564, Pf08565, Pf10211" 12539 ENSMUSG00000019471.10 Cdc37 9 Downregulation of ERBB2 signaling PI3K-Akt signaling pathway 0 High A0A087WNZ5 Lymphocyte antigen 6C1 OS=Mus musculus OX=10090 GN=Ly6c1 PE=1 SV=1 0 11.448 26 3 6 3 147 16 7.23 2 1 2 2 2 2 7370239.891 8304794.906 18771035.44 3 2 4 membrane Pf00021 17067 ENSMUSG00000079018.10 Ly6c1 15 0 High D3YXW4 Unconventional myosin-X (Fragment) OS=Mus musculus OX=10090 GN=Myo10 PE=1 SV=1 0 8.671 14 3 6 1 237 28.6 9.99 2 2 2 2 2 2 Met-loss [N-Term] regulation of biological process catalytic activity;motor activity;nucleotide binding;protein binding Pf00063 ENSMUSG00000022272.17 15 0 High Q9CQ62 "2,4-dienoyl-CoA reductase, mitochondrial OS=Mus musculus OX=10090 GN=Decr1 PE=1 SV=1" 0 12.502 19 4 6 4 335 36.2 8.95 3 2 4 2 1379210.188 4318009.875 4998201.813 2 3 3 cell organization and biogenesis;metabolic process cytosol;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00106, Pf08659, Pf13561" 67460 ENSMUSG00000028223.8 Decr1 4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 0 High A0A1L1SQR4 Dedicator of cytokinesis protein 6 OS=Mus musculus OX=10090 GN=Dock6 PE=1 SV=1 0 6.726 2 3 6 1 2111 236.4 6.87 2 3 2 4 regulation of biological process;response to stimulus cytoplasm;cytosol "Pf06920, Pf11878, Pf14429" 319899 ENSMUSG00000032198.9 Dock6 9 0 High Q8R0X7 Sphingosine-1-phosphate lyase 1 OS=Mus musculus OX=10090 GN=Sgpl1 PE=1 SV=1 0 18.145 7 3 6 3 568 63.6 9.1 2 2 2 2 2 2 2976700.75 3683183.5 2712385.938 2 3 2 cell death;cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity "Pf00155, Pf00266, Pf00282, Pf01212, Pf05889" 20397 ENSMUSG00000020097.14 Sgpl1 10 Sphingolipid de novo biosynthesis Metabolic pathways; Sphingolipid signaling pathway; Sphingolipid metabolism 0 High Q9D4J1 EF-hand domain-containing protein D1 OS=Mus musculus OX=10090 GN=Efhd1 PE=1 SV=1 0 19.054 25 5 6 5 240 27 6.02 4 2 4 2 298206.5391 4919745.375 3374818.563 2 5 3 cell organization and biogenesis membrane;mitochondrion metal ion binding Pf13499 98363 ENSMUSG00000026255.15 Efhd1 1 0 High Q8CIB5 Fermitin family homolog 2 OS=Mus musculus OX=10090 GN=Fermt2 PE=1 SV=1 0 21.112 8 4 6 4 680 77.8 6.7 2 4 2 4 408552.5078 1364433.188 2549577.75 2 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;membrane;nucleus "Pf00169, Pf00373" 218952 ENSMUSG00000037712.15 Fermt2 14 Cell-extracellular matrix interactions 0 High Q9D6Y7 Mitochondrial peptide methionine sulfoxide reductase OS=Mus musculus OX=10090 GN=Msra PE=1 SV=1 0 13.798 26 4 6 4 233 26 8.41 1 1 4 1 1 4 643905.5156 3087376.625 6563549.375 2 4 4 metabolic process cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity Pf01625 110265 ENSMUSG00000054733.9 Msra 14 Protein repair 0 High Q9EQH3 Vacuolar protein sorting-associated protein 35 OS=Mus musculus OX=10090 GN=Vps35 PE=1 SV=1 0 12.074 5 4 6 4 796 91.7 5.44 4 2 4 2 824515.4063 3411346.625 4512536 3 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane;mitochondrion;vacuole protein binding;transporter activity Pf03635 65114 ENSMUSG00000031696.9 Vps35 8 WNT ligand biogenesis and trafficking Endocytosis 0 High A0A0R4J187 X-ray repair cross-complementing protein 6 OS=Mus musculus OX=10090 GN=Xrcc6 PE=1 SV=1 0 16.788 12 6 6 6 608 69.4 6.52 1 5 1 5 1388764.047 2979930.813 4413974.906 3 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf02037, Pf02735, Pf03730, Pf03731" 14375 ENSMUSG00000022471.13 Xrcc6 15 Neutrophil degranulation; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P30275 "Creatine kinase U-type, mitochondrial OS=Mus musculus OX=10090 GN=Ckmt1 PE=1 SV=1" 0 9.335 18 4 6 4 418 47 8.16 1 3 2 1 3 2 1011122.063 1403549.75 3123206.688 1 1 2 metabolic process;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00217, Pf02807" 12716 ENSMUSG00000000308.14 Ckmt1 2 Creatine metabolism Arginine and proline metabolism; Metabolic pathways 0 High Q9JKC8 AP-3 complex subunit mu-1 OS=Mus musculus OX=10090 GN=Ap3m1 PE=1 SV=1 0 11.832 12 5 6 5 418 46.9 6.93 2 4 2 4 409148.0547 2275862.906 2676397.375 3 4 4 cellular component movement;transport Golgi;membrane protein binding "Pf00928, Pf01217" 55946 ENSMUSG00000021824.12 Ap3m1 14 Lysosome 0 High Q80SW1 S-adenosylhomocysteine hydrolase-like protein 1 OS=Mus musculus OX=10090 GN=Ahcyl1 PE=1 SV=1 0 11.049 9 4 6 1 530 58.9 6.89 2 2 2 2 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00670, Pf01262, Pf01488, Pf02254, Pf02826, Pf05221" 229709 ENSMUSG00000027893.14 Ahcyl1 3 Ion homeostasis Metabolic pathways; Cysteine and methionine metabolism 0 High Q91YR7 Pre-mRNA-processing factor 6 OS=Mus musculus OX=10090 GN=Prpf6 PE=1 SV=1 0 13.931 6 5 6 5 941 106.7 8.09 5 1 5 1 4040616.938 3488443.906 5 4 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf06424, Pf13414, Pf14559" 68879 ENSMUSG00000002455.14 Prpf6 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High B2RSU6 Cingulin-like 1 OS=Mus musculus OX=10090 GN=Cgnl1 PE=1 SV=1 0 12.604 4 4 6 4 1297 148.1 5.77 3 2 3 3 2336886.004 5025807.281 6640965.438 4 4 4 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00261, Pf00769, Pf01496, Pf01576, Pf02463, Pf03961, Pf03962, Pf04094, Pf04111, Pf04156, Pf05262, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06008, Pf06160, Pf06548, Pf06785, Pf06810, Pf07111, Pf07888, Pf07946, Pf09726, Pf09730, Pf10174, Pf12128, Pf13166, Pf13514, Pf13654, Pf13851, Pf13863, Pf13868, Pf15070, Pf15450, Pf15619" 68178 ENSMUSG00000032232.14 Cgnl1 9 0 High Q62009 Periostin OS=Mus musculus OX=10090 GN=Postn PE=1 SV=2 0 16.154 9 5 6 5 838 93.1 7.53 1 1 4 1 1 4 320408.4219 368038.7813 2801622.688 2 1 3 cell communication;cell growth;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;extracellular;Golgi metal ion binding;protein binding "Pf02469, Pf07546" 50706 ENSMUSG00000027750.16 Postn 3 0 High Q76MZ3 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus OX=10090 GN=Ppp2r1a PE=1 SV=3 0 16.939 10 5 6 5 589 65.3 5.11 1 5 1 5 1044457.672 3103161.188 5916156.5 3 3 4 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;protein binding "Pf02985, Pf13513, Pf13646" 51792 ENSMUSG00000007564.14 Ppp2r1a 17 "Loss of Nlp from mitotic centrosomes; RAF activation; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Spry regulation of FGF signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Activated TLR4 signalling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Signaling by GPCR; Regulation of TP53 Degradation; Negative regulation of MAPK pathway; RHO GTPases Activate Formins; Recruitment of NuMA to mitotic centrosomes; Cyclin A/B1/B2 associated events during G2/M transition; Interleukin-20 family signaling; Beta-catenin phosphorylation cascade; Recruitment of mitotic centrosome proteins and complexes; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of PLK1 Activity at G2/M Transition; CTLA4 inhibitory signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; ERKs are inactivated; DARPP-32 events; Initiation of Nuclear Envelope Reformation" mRNA surveillance pathway; Chagas disease (American trypanosomiasis); Dopaminergic synapse; Hippo signaling pathway; Oocyte meiosis; Sphingolipid signaling pathway; Long-term depression; TGF-beta signaling pathway; Hepatitis C; PI3K-Akt signaling pathway; AMPK signaling pathway; Tight junction; Adrenergic signaling in cardiomyocytes 0 High Q3TUQ5 Pinin OS=Mus musculus OX=10090 GN=Pnn PE=1 SV=1 0 20.425 8 4 6 4 726 82.5 7.01 4 1 5 1 293506.2188 5358944.906 6311677.375 1 4 3 metabolic process;regulation of biological process cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;RNA binding "Pf04696, Pf04697" 18949 ENSMUSG00000020994.5 Pnn 12 mRNA surveillance pathway; RNA transport 0 High Q9D0M5 "Dynein light chain 2, cytoplasmic OS=Mus musculus OX=10090 GN=Dynll2 PE=1 SV=1" 0 5.615 21 2 6 1 89 10.3 7.37 2 2 1 2 2 2 1334611.875 5383175 4725954.469 2 2 2 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding Pf01221 68097 ENSMUSG00000020483.14 Dynll2 11 Activation of BMF and translocation to mitochondria; COPI-mediated anterograde transport; Macroautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR); Intraflagellar transport; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; COPI-independent Golgi-to-ER retrograde traffic; RHO GTPases Activate Formins; MHC class II antigen presentation Vasopressin-regulated water reabsorption 1 High Q8CFA2 "Aminomethyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Amt PE=1 SV=1" 0 11.351 11 3 6 3 403 44 8.7 1 2 2 1 3 2 918606.3125 2442392.688 3003593.625 3 3 3 metabolic process mitochondrion catalytic activity "Pf01571, Pf08669" 434437 ENSMUSG00000032607.12 Amt 9 Glycine degradation "Metabolic pathways; Glycine, serine and threonine metabolism; Carbon metabolism; One carbon pool by folate; Glyoxylate and dicarboxylate metabolism" 0 High P35278 Ras-related protein Rab-5C OS=Mus musculus OX=10090 GN=Rab5c PE=1 SV=2 0 14.094 23 4 6 4 216 23.4 8.41 3 3 3 3 550105.625 3133028.156 4712737.438 1 3 3 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endosome;membrane catalytic activity;nucleotide binding;protein binding "Pf00009, Pf00025, Pf00071, Pf04670, Pf08477" 19345 ENSMUSG00000019173.11 Rab5c 11 Neutrophil degranulation; Golgi Associated Vesicle Biogenesis Endocytosis; Ras signaling pathway; Tuberculosis; Phagosome; Vasopressin-regulated water reabsorption; Amoebiasis 0 High A0A0R4J1Q0 Enhancer of mRNA-decapping protein 4 OS=Mus musculus OX=10090 GN=Edc4 PE=1 SV=1 0 13.75 5 4 6 4 1390 150.6 5.68 2 1 3 2 1 3 1330456.281 1913038.938 2313777.875 3 2 3 metabolic process cytoplasm;membrane;nucleus protein binding Pf00400 234699 ENSMUSG00000036270.16 Edc4 8 mRNA decay by 5' to 3' exoribonuclease 0 High O88342 WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Wdr1 PE=1 SV=3 0 11.535 9 3 6 3 606 66.4 6.6 1 3 2 1 3 2 1532154.563 2499028.938 1376868.25 2 2 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding "Pf00400, Pf04762, Pf08662, Pf14783" 22388 ENSMUSG00000005103.12 Wdr1 5 Platelet degranulation 0 High Q8K1K2 26S proteasome regulatory subunit 8 OS=Mus musculus OX=10090 GN=Psmc5 PE=1 SV=1 0 16.138 18 4 6 4 348 38.7 5.96 3 3 3 3 321088.9688 1295646.813 1 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401" 19184 ENSMUSG00000020708.12 Psmc5 11 0 High A0A0R4J119 Cytoplasmic FMR1-interacting protein OS=Mus musculus OX=10090 GN=Cyfip1 PE=1 SV=1 0 12.802 5 5 6 5 1251 144.8 6.95 1 2 3 1 2 3 1450400.656 8628300.813 18927022.63 2 5 4 cell differentiation;cell growth;cell organization and biogenesis;development;regulation of biological process;response to stimulus cytoplasm protein binding;RNA binding "Pf05994, Pf07159" 20430 ENSMUSG00000030447.15 Cyfip1 7 0 High A2AVR6 Acyl-coenzyme A thioesterase 11 OS=Mus musculus OX=10090 GN=Acot11 PE=1 SV=1 0 13.696 11 5 6 5 614 69.3 7.03 2 2 2 2 2 2 770447.8906 2216007.109 3246376.5 3 4 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity "Pf01852, Pf03061, Pf10604" 329910 ENSMUSG00000034853.16 Acot11 4 0 High P47753 F-actin-capping protein subunit alpha-1 OS=Mus musculus OX=10090 GN=Capza1 PE=1 SV=4 0 16.013 22 4 6 3 286 32.9 5.55 3 2 3 3 1100710.031 3253855.688 2861367.625 2 3 2 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding Pf01267 12340 Capza1 3 Endocytosis 0 High P46638 Ras-related protein Rab-11B OS=Mus musculus OX=10090 GN=Rab11b PE=1 SV=3 0 9.795 16 3 6 3 218 24.5 5.94 3 3 3 3 135007.4531 892251.5938 1290350.75 1 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endosome;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf01926, Pf08477, Pf13401" 19326 ENSMUSG00000077450.12 Rab11b 17 TBC/RABGAPs; RAB geranylgeranylation Endocytosis; AMPK signaling pathway; Vasopressin-regulated water reabsorption 0 Low D3Z4R1 Probable ATP-dependent DNA helicase HFM1 OS=Mus musculus OX=10090 GN=Hfm1 PE=3 SV=2 0.088 1.203 0 1 6 1 1434 161.3 7.85 1 1 1 3 2 1 34926136 38441952 53254288 1 1 1 cell differentiation;metabolic process cytoplasm catalytic activity;DNA binding;nucleotide binding "Pf00270, Pf00271, Pf02889, Pf04851" 330149 ENSMUSG00000043410.16 Hfm1 5 0 High B1AVD2 Xaa-Pro aminopeptidase 2 OS=Mus musculus OX=10090 GN=Xpnpep2 PE=1 SV=1 0 17.048 8 5 6 5 741 83.7 6.67 2 4 2 4 625760.6094 1195647.141 2765477.5 3 3 3 metabolic process membrane catalytic activity;metal ion binding "Pf00557, Pf01321" 170745 ENSMUSG00000037005.16 Xpnpep2 X Protein digestion and absorption 0 High Q91X78 Erlin-1 OS=Mus musculus OX=10090 GN=Erlin1 PE=1 SV=2 0 13.679 14 4 6 1 348 39.2 7.21 2 3 2 4 109053.5156 522343.4375 376159.4063 1 1 1 0 High Q8R0B4 TAR DNA binding protein OS=Mus musculus OX=10090 GN=Tardbp PE=1 SV=1 0 12.125 15 4 5 4 295 33.3 7.06 1 2 2 1 2 2 740324.875 2788332.313 3218119.688 2 4 3 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 230908 ENSMUSG00000041459.15 Tardbp 4 0 High P62900 60S ribosomal protein L31 OS=Mus musculus OX=10090 GN=Rpl31 PE=1 SV=1 0.002 4.479 14 2 5 2 125 14.5 10.54 1 1 2 1 1 3 2273187.25 6322108 7486801.25 2 2 2 metabolic process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01198 114641 ENSMUSG00000073702.11 Rpl31 1 Ribosome 0 High A0A494BBA8 40S ribosomal protein S30 OS=Mus musculus OX=10090 GN=Fau PE=1 SV=1 0 4.925 10 1 5 1 98 10.9 11.56 1 1 1 2 2 1 966811.4375 2600737.75 3173231.75 1 1 1 0 High D3Z158 Glutaminyl-tRNA synthetase OS=Mus musculus OX=10090 GN=Qars PE=1 SV=2 0 16.507 9 5 5 5 751 85 7.3 3 2 3 2 390564.3984 2231339.25 3532377.25 2 3 4 metabolic process cytoplasm catalytic activity;nucleotide binding "Pf00749, Pf03950, Pf04557, Pf04558" ENSMUSG00000032604.16 9 0 High P10852 4F2 cell-surface antigen heavy chain OS=Mus musculus OX=10090 GN=Slc3a2 PE=1 SV=1 0 15.75 9 4 5 4 526 58.3 5.91 3 2 3 2 436893.2578 2189817.406 3023947.594 3 3 4 metabolic process;response to stimulus;transport cell surface;cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding;transporter activity Pf00128 17254 ENSMUSG00000010095.13 Slc3a2 19 Amino acid transport across the plasma membrane; Tryptophan catabolism; Basigin interactions mTOR signaling pathway; Protein digestion and absorption 0 High Q91WR5 Aldo-keto reductase family 1 member C21 OS=Mus musculus OX=10090 GN=Akr1c21 PE=1 SV=2 0 7.572 15 3 5 3 323 36.9 7.18 1 1 3 1 1 3 876125.9688 1953961.188 7095678.875 2 2 3 metabolic process cytoplasm;cytosol catalytic activity;nucleotide binding Pf00248 77337 ENSMUSG00000021207.8 Akr1c21 13 RA biosynthesis pathway; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Signaling by GPCR; Retinoid metabolism and transport; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0 High P30677 Guanine nucleotide-binding protein subunit alpha-14 OS=Mus musculus OX=10090 GN=Gna14 PE=1 SV=2 0 9.076 10 3 5 3 355 41.5 6.3 1 1 3 1 1 3 669632.75 1953886.094 2475745.188 2 3 3 regulation of biological process;response to stimulus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503" 14675 ENSMUSG00000024697.3 Gna14 19 Platelet sensitization by LDL; ADP signalling through P2Y purinoceptor 1; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Acetylcholine regulates insulin secretion; Thrombin signalling through proteinase activated receptors (PARs); Gastrin-CREB signalling pathway via PKC and MAPK; Thromboxane signalling through TP receptor Chagas disease (American trypanosomiasis); Calcium signaling pathway; Amoebiasis 0 High Q6AXB7 Fragile X mental retardation syndrome 1 homolog OS=Mus musculus OX=10090 GN=Fmr1 PE=1 SV=1 0 9.92 6 3 5 2 614 68.8 7.42 3 1 4 1 1092166.172 2362509.5 2 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf05641, Pf12235, Pf13014" 14265 ENSMUSG00000000838.17 Fmr1 X RNA transport 0 High Q9DBN5 "Lon protease homolog 2, peroxisomal OS=Mus musculus OX=10090 GN=Lonp2 PE=1 SV=1" 0 8.521 6 4 5 4 852 94.5 7.23 2 3 2 3 211962.3438 995557.1875 1920474.375 2 2 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00004, Pf01202, Pf02190, Pf04124, Pf05362, Pf07726, Pf07728, Pf13191, Pf13541" 66887 ENSMUSG00000047866.18 Lonp2 8 0 High G3X9C2 F-box only protein 50 OS=Mus musculus OX=10090 GN=Nccrp1 PE=1 SV=2 0 7.762 14 4 5 4 266 30.4 7.12 2 2 1 2 2 1 4265423.594 2356751.688 2617598.313 4 4 3 regulation of biological process cytoplasm Pf04300 233038 Nccrp1 7 0 High Q8K0L3 "Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1" 0 15.09 9 4 5 4 575 64.2 8.31 1 1 3 1 1 3 1491321.781 3438778.5 5762905.125 2 3 4 metabolic process mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding "Pf00501, Pf13193" 233799 ENSMUSG00000030945.17 Acsm2 7 Conjugation of phenylacetate with glutamine; Conjugation of benzoate with glycine; Conjugation of salicylate with glycine Metabolic pathways; Butanoate metabolism 0 High D3YTT4 "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acad8 PE=1 SV=1" 0 11.286 9 3 5 3 413 45 8.02 2 3 2 3 509200.9844 2516641.156 4338196.313 2 3 3 metabolic process catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" ENSMUSG00000031969.16 9 Branched-chain amino acid catabolism 0 High Q8CGV4 Retinol dehydrogenase 1 (All trans) OS=Mus musculus OX=10090 GN=Rdh1 PE=2 SV=1 0 9.907 10 4 5 4 317 35.9 9.1 2 3 2 3 1813624.531 2967586 3 4 metabolic process catalytic activity "Pf00106, Pf08643, Pf13561" 107605 ENSMUSG00000089789.1 Rdh1 10 RA biosynthesis pathway 0 High Q8C6B0 Methyltransferase-like 7A1 OS=Mus musculus OX=10090 GN=Mettl7a1 PE=1 SV=1 0 6.586 12 2 5 2 244 28.1 8.31 2 2 3 2 471565.25 2349723.313 3207525 1 2 2 metabolic process membrane catalytic activity "Pf01209, Pf01739, Pf05148, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847" 70152 ENSMUSG00000054619.6 Mettl7a1 15 Neutrophil degranulation 0 Medium Q9D023 Mitochondrial pyruvate carrier 2 OS=Mus musculus OX=10090 GN=Mpc2 PE=1 SV=1 0.027 1.72 6 1 5 1 127 14.3 10.61 1 1 1 1 2 2 821476.75 1609943 2248055 1 1 1 regulation of biological process;transport membrane;mitochondrion;nucleus transporter activity Pf03650 70456 ENSMUSG00000026568.6 Mpc2 1 0 High P59158 Solute carrier family 12 member 3 OS=Mus musculus OX=10090 GN=Slc12a3 PE=1 SV=1 0 11.985 3 2 5 2 1002 110.6 7.56 2 2 2 3 1738433.313 3640938.625 2 2 transport cytosol;membrane protein binding;transporter activity "Pf00324, Pf08403, Pf13520" 20497 ENSMUSG00000031766.4 Slc12a3 8 Cation-coupled Chloride cotransporters 0 High A0A0A6YY34 Glutathione peroxidase OS=Mus musculus OX=10090 GN=Gpx1 PE=1 SV=1 0 9.851 33 4 5 4 144 16.3 7.25 1 2 2 1 2 2 697747.1875 1 metabolic process;response to stimulus antioxidant activity;catalytic activity Pf00255 ENSMUSG00000063856.7 9 0 High P39876 Metalloproteinase inhibitor 3 OS=Mus musculus OX=10090 GN=Timp3 PE=1 SV=1 0 8.507 15 3 5 3 211 24.2 8.76 2 1 2 2 1 2 2283519.125 3102899.969 3545027.125 3 3 3 regulation of biological process;response to stimulus cytoplasm;extracellular;nucleus enzyme regulator activity;metal ion binding;protein binding Pf00965 21859 ENSMUSG00000020044.13 Timp3 10 Platelet degranulation MicroRNAs in cancer; Proteoglycans in cancer 0 High P29788 Vitronectin OS=Mus musculus OX=10090 GN=Vtn PE=1 SV=2 0 16.993 10 3 5 3 478 54.8 5.88 1 3 1 4 1146417.875 5009865.188 1471451.625 2 3 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;organelle lumen protein binding;receptor activity "Pf00045, Pf01033" 22370 ENSMUSG00000017344.4 Vtn 11 Regulation of Complement cascade; ECM proteoglycans; Molecules associated with elastic fibres; Syndecan interactions; Integrin cell surface interactions Focal adhesion; Complement and coagulation cascades; Proteoglycans in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High E9QLB2 Lysophospholipase-like protein 1 OS=Mus musculus OX=10090 GN=Lyplal1 PE=1 SV=1 0 5.928 9 2 5 2 239 26.3 7.88 1 2 2 1 2 2 2128201.188 2397712.969 1500911.031 2 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol catalytic activity "Pf02230, Pf07859, Pf12695, Pf12697" 226791 ENSMUSG00000039246.8 Lyplal1 1 0 High Q8BJ64 "Choline dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Chdh PE=1 SV=1" 0 10.857 12 4 5 4 596 66.4 8.51 2 3 2 3 571885.5625 1542564.75 2996214.875 1 3 2 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding "Pf00732, Pf01266, Pf05199, Pf05834, Pf13450" 218865 ENSMUSG00000015970.18 Chdh 14 Choline catabolism "Metabolic pathways; Glycine, serine and threonine metabolism" 0 High Q3TNA1 Xylulose kinase OS=Mus musculus OX=10090 GN=Xylb PE=1 SV=1 0 7.941 6 2 5 2 551 59.5 6.9 1 1 2 1 1 3 657315.7813 1951881.25 2327576.688 2 2 2 metabolic process cytoplasm catalytic activity;nucleotide binding "Pf00370, Pf02782" 102448 ENSMUSG00000035769.9 Xylb 9 Catabolism of glucuronate to xylulose-5-phosphate Metabolic pathways; Pentose and glucuronate interconversions 0 High Q8K382 DENN domain-containing protein 1A OS=Mus musculus OX=10090 GN=Dennd1a PE=1 SV=2 0 8.097 5 3 5 3 1016 111.5 6.79 2 3 2 3 960704.6094 2127473.25 4039757.625 3 3 3 regulation of biological process;transport cytosol;membrane protein binding "Pf02141, Pf03455, Pf03456" 227801 ENSMUSG00000035392.17 Dennd1a 2 RAB GEFs exchange GTP for GDP on RABs 0 High H3BKW0 Cleavage and polyadenylation-specificity factor subunit 6 (Fragment) OS=Mus musculus OX=10090 GN=Cpsf6 PE=1 SV=1 0 14.23 23 2 5 2 182 21.2 9.73 2 1 3 2 240122.9063 2149503 2859772.594 2 2 2 ENSMUSG00000055531.12 10 0 High B1AVZ0 Uracil phosphoribosyltransferase homolog OS=Mus musculus OX=10090 GN=Uprt PE=1 SV=1 0 9.633 8 2 5 2 310 34.3 6.23 2 2 2 3 132289.7344 1286512.188 2055720.594 1 2 2 metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding "Pf00156, Pf14681" 331487 ENSMUSG00000073016.3 Uprt X Metabolic pathways; Pyrimidine metabolism 0 High Q9CS42 Ribose-phosphate pyrophosphokinase 2 OS=Mus musculus OX=10090 GN=Prps2 PE=1 SV=4 0 16.664 19 4 5 4 318 34.8 6.61 2 3 2 3 1066612.156 2723250.469 2 3 metabolic process catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00156, Pf13793, Pf14572" 110639 ENSMUSG00000025742.5 Prps2 X Metabolic pathways; Biosynthesis of amino acids; Purine metabolism; Pentose phosphate pathway; Carbon metabolism 0 High P10639 Thioredoxin OS=Mus musculus OX=10090 GN=Txn PE=1 SV=3 0 7.016 21 2 5 2 105 11.7 4.92 2 2 1 2 2 1 5960772.313 23241544.25 32477889.5 2 2 2 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00085, Pf13098, Pf13899, Pf13905" 22166 ENSMUSG00000028367.5 Txn1 4 Interconversion of nucleotide di- and triphosphates; Protein repair; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Oxidative Stress Induced Senescence; The NLRP3 inflammasome NOD-like receptor signaling pathway 0 High Q9CRB9 MICOS complex subunit Mic19 OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 0 10.896 19 3 5 3 227 26.3 8.37 1 2 2 1 2 2 544758.9063 3184440.781 5191464.5 2 3 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;nucleus protein binding;structural molecule activity "Pf05300, Pf06747" 66075 ENSMUSG00000053768.13 Chchd3 6 0 High A0A5K1VVS7 Protein unc-45 homolog A OS=Mus musculus OX=10090 GN=Unc45a PE=1 SV=1 0 12.605 8 5 5 5 1088 119.1 6.9 1 4 1 4 206493.3594 932102.6875 2622156.172 1 3 4 0 High Q6ZQ38 Cullin-associated NEDD8-dissociated protein 1 OS=Mus musculus OX=10090 GN=Cand1 PE=1 SV=2 0 16.13 8 5 5 5 1230 136.2 5.78 1 4 1 4 72076.33594 323596.0625 848212.875 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;membrane;nucleus protein binding "Pf08623, Pf12755, Pf13513" 71902 ENSMUSG00000020114.12 Cand1 10 Neddylation; Neutrophil degranulation; Iron uptake and transport 0 Medium Q3V1N1 Malignant fibrous histiocytoma-amplified sequence 1 homolog OS=Mus musculus OX=10090 GN=Mfhas1 PE=1 SV=2 0.041 1.497 1 1 5 1 1048 116.5 7.18 1 1 1 2 2 1 80878080 544617856 595831424 1 1 1 regulation of biological process;response to stimulus membrane protein binding "Pf12799, Pf13855" 52065 ENSMUSG00000070056.6 Mfhas1 8 0 High Q9Z1N5 Spliceosome RNA helicase Ddx39b OS=Mus musculus OX=10090 GN=Ddx39b PE=1 SV=1 0 8.499 12 3 5 3 428 49 5.67 2 3 2 3 181217.9375 1694045.813 2058632.375 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf14617" 53817 ENSMUSG00000019432.15 Ddx39b 17 mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; Spliceosome; Influenza A; RNA transport 0 High A0A0U1RP06 DNA repair protein-complementing XP-C cells homolog (Fragment) OS=Mus musculus OX=10090 GN=Xpc PE=1 SV=1 0 8.979 7 4 5 4 697 78 8.78 3 2 3 2 2476096.188 2417357.25 4 3 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding "Pf03835, Pf10403" ENSMUSG00000030094.8 6 0 High Q9CQL1 Protein mago nashi homolog 2 OS=Mus musculus OX=10090 GN=Magohb PE=2 SV=1 0 10.333 30 4 5 4 146 17.1 6.39 4 5 13016319.81 3769109.25 4 3 metabolic process;transport nucleus;spliceosomal complex RNA binding Pf02792 66441 Magohb 6 mRNA surveillance pathway; Spliceosome; RNA transport 0 High B1AVH5 Coronin OS=Mus musculus OX=10090 GN=Coro2a PE=1 SV=1 0 9.44 7 3 5 3 543 61.7 8.15 3 2 3 2 2797790.688 3003352.938 3 3 cell organization and biogenesis cytoskeleton protein binding "Pf00400, Pf08953, Pf08954" 107684 ENSMUSG00000028337.14 Coro2a 4 0 High P63158 High mobility group protein B1 OS=Mus musculus OX=10090 GN=Hmgb1 PE=1 SV=2 0 9.741 22 3 5 3 215 24.9 5.74 1 1 3 1 1 3 1905355.531 4316612.719 5167095.75 3 3 3 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;chromosome;cytoplasm;endosome;extracellular;membrane;nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00505, Pf09011" 15289; 100862258 ENSMUSG00000066551.12 Hmgb1; Gm21596; LOC100862258 5; 2 DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activation of DNA fragmentation factor; Activated TLR4 signalling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Neutrophil degranulation; TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; Interleukin-1 family signaling; Regulation of TLR by endogenous ligand Base excision repair 0 High Q80X85 "28S ribosomal protein S7, mitochondrial OS=Mus musculus OX=10090 GN=Mrps7 PE=1 SV=1" 0 11.068 19 4 5 4 242 28 9.94 3 1 1 3 1 1 700628.7188 1914923.813 1438734.5 4 3 2 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00177 50529 ENSMUSG00000046756.10 Mrps7 11 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High P47857 "ATP-dependent 6-phosphofructokinase, muscle type OS=Mus musculus OX=10090 GN=Pfkm PE=1 SV=3" 0 9.548 7 4 5 2 780 85.2 8 2 3 2 3 599737.5313 1089599.781 2835323.5 2 2 2 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 18642 ENSMUSG00000033065.13 Pfkm 15 Glycolysis RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Pentose phosphate pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer 0 High A0A0A0MQH5 Microtubule-actin cross-linking factor 1 (Fragment) OS=Mus musculus OX=10090 GN=Macf1 PE=1 SV=6 0 16.354 24 4 5 1 369 42.7 4.73 1 4 1 4 3465462.5 1 regulation of biological process;response to stimulus catalytic activity;protein binding Pf00435 ENSMUSG00000028649.17 4 0 High Q9DB29 Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Mus musculus OX=10090 GN=Iah1 PE=1 SV=1 0 9.17 22 3 5 3 249 28 5.52 1 3 1 4 891228.875 1680104.875 1 1 metabolic process catalytic activity "Pf00657, Pf13472" 67732 ENSMUSG00000062054.6 Iah1 12 0 High Q9EPU0 Regulator of nonsense transcripts 1 OS=Mus musculus OX=10090 GN=Upf1 PE=1 SV=2 0 10.111 6 4 5 4 1124 123.9 6.61 1 3 1 1 3 1 915490.2344 1630351.625 688920.25 3 2 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf04851, Pf09416, Pf13086, Pf13087, Pf13245, Pf13604" 19704 ENSMUSG00000058301.8 Upf1 8 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High P14069 Protein S100-A6 OS=Mus musculus OX=10090 GN=S100a6 PE=1 SV=3 0 17.958 58 3 5 3 89 10 5.48 2 3 2 3 610517.6494 1949081.117 4101951.625 2 3 3 Met-loss+Acetyl [N-Term] transport cytoplasm;cytosol;extracellular;membrane;nucleus metal ion binding;protein binding;transporter activity Pf01023 20200 ENSMUSG00000001025.8 S100a6 3 0 High Q9WV68 "Peroxisomal 2,4-dienoyl-CoA reductase OS=Mus musculus OX=10090 GN=Decr2 PE=1 SV=1" 0 17.368 18 4 5 4 292 31.3 8.81 1 4 1 4 374075.5352 3078388.813 6618017.375 2 3 4 metabolic process membrane catalytic activity;protein binding "Pf00106, Pf08659, Pf13561" 26378 ENSMUSG00000036775.12 Decr2 17 Beta-oxidation of very long chain fatty acids Peroxisome 0 High A0A2R8VHY9 Poly(rC)-binding protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Pcbp2 PE=1 SV=1 0 12.08 18 4 5 2 249 26.4 7.77 1 4 1 4 1109033.25 3707500.625 4059085 1 2 2 0 High Q924X2 "Carnitine O-palmitoyltransferase 1, muscle isoform OS=Mus musculus OX=10090 GN=Cpt1b PE=1 SV=1" 0 9.341 6 3 5 2 772 88.2 8.38 1 2 2 1 2 2 224029.2344 911235 1897961.938 1 1 2 metabolic process;transport membrane;mitochondrion catalytic activity Pf00755 12895 ENSMUSG00000078937.8 Cpt1b 15 Signaling by Retinoic Acid; Import of palmitoyl-CoA into the mitochondrial matrix PPAR signaling pathway; Fatty acid metabolism; Fatty acid degradation; Insulin resistance; Adipocytokine signaling pathway; AMPK signaling pathway; Glucagon signaling pathway 0 High Q9Z1J3 "Cysteine desulfurase, mitochondrial OS=Mus musculus OX=10090 GN=Nfs1 PE=1 SV=3" 0 8.626 9 4 5 4 459 50.5 8.16 1 4 1 4 636444.8438 4778237.375 5621042.25 2 4 4 cell organization and biogenesis;metabolic process cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00266, Pf00282, Pf01212" 18041 ENSMUSG00000027618.17 Nfs1 2 Mitochondrial iron-sulfur cluster biogenesis; Molybdenum cofactor biosynthesis Thiamine metabolism; Metabolic pathways; Sulfur relay system 0 High P70691 UDP-glucuronosyltransferase 1-2 OS=Mus musculus OX=10090 GN=Ugt1a2 PE=1 SV=1 0 20.897 9 3 5 3 533 60.2 8.05 1 3 1 4 1079515.234 2899411.656 3909219.188 3 3 3 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00201, Pf04101" 22236 ENSMUSG00000090171.1 Ugt1a2 1 Heme degradation; Glucuronidation Steroid hormone biosynthesis; Drug metabolism - cytochrome P450; Retinol metabolism; Metabolic pathways; Drug metabolism - other enzymes; Ascorbate and aldarate metabolism; Chemical carcinogenesis; Porphyrin and chlorophyll metabolism; Pentose and glucuronate interconversions; Metabolism of xenobiotics by cytochrome P450 0 High Q8C2Q7 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus OX=10090 GN=Hnrnph1 PE=1 SV=1 0 9.586 8 3 5 3 472 51.2 6.8 2 3 2 3 562224.3906 1602803.438 3081367.625 2 2 2 metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 59013 ENSMUSG00000007850.16 Hnrnph1 11 0 High P61750 ADP-ribosylation factor 4 OS=Mus musculus OX=10090 GN=Arf4 PE=1 SV=2 0 16.259 35 4 5 2 180 20.4 7.14 2 3 2 3 362194.4688 623864.25 1 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439" 11843 ENSMUSG00000021877.11 Arf4 14 VxPx cargo-targeting to cilium; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q9R0B9 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Mus musculus OX=10090 GN=Plod2 PE=1 SV=2" 0 12.144 9 5 5 5 737 84.4 6.89 5 5 3227913.344 112996.3906 4 1 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf03171 26432 ENSMUSG00000032374.14 Plod2 9 Collagen biosynthesis and modifying enzymes Lysine degradation 0 High J3QMG3 Voltage-dependent anion-selective channel protein 3 OS=Mus musculus OX=10090 GN=Vdac3 PE=1 SV=1 0 16.296 14 3 5 3 284 30.8 8.79 2 2 2 3 1578672.125 2241615.25 595864 2 2 1 regulation of biological process;transport membrane;mitochondrion transporter activity Pf01459 ENSMUSG00000008892.12 8 0 High P32067 Lupus La protein homolog OS=Mus musculus OX=10090 GN=Ssb PE=1 SV=1 0 6.696 9 4 5 3 415 47.7 9.77 1 2 2 1 2 2 2213067.375 404507.8438 2 1 metabolic process;transport cytoplasm;nucleus RNA binding "Pf00076, Pf05383, Pf08777, Pf14259" 20823 ENSMUSG00000068882.13 Ssb 2 Systemic lupus erythematosus 0 High Q64442 Sorbitol dehydrogenase OS=Mus musculus OX=10090 GN=Sord PE=1 SV=3 0 9.013 10 4 5 4 357 38.2 7.02 4 1 4 1 1855824.75 3143164.5 867025.1875 3 3 1 cellular component movement;metabolic process;response to stimulus membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00107, Pf08240" 20322 ENSMUSG00000027227.7 Sord 2 Fructose biosynthesis; Catabolism of glucuronate to xylulose-5-phosphate Metabolic pathways; Fructose and mannose metabolism; Pentose and glucuronate interconversions 0 High P17182 Alpha-enolase OS=Mus musculus OX=10090 GN=Eno1 PE=1 SV=3 0 6.806 10 3 5 3 434 47.1 6.8 2 1 2 2 1 2 619213.875 733048.5625 1028391 1 1 1 metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00113, Pf03952, Pf13378" 13806; 433182 ENSMUSG00000059040.4; ENSMUSG00000063524.13 Eno1; Gm5506; Eno1b 4; 18 Gluconeogenesis; Glycolysis RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism 0 High Q6PE01 U5 small nuclear ribonucleoprotein 40 kDa protein OS=Mus musculus OX=10090 GN=Snrnp40 PE=1 SV=1 0 14.35 14 4 5 4 358 39.3 8.1 3 2 3 2 310207.2422 3136184.063 4487386.625 2 4 3 metabolic process cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf00400 66585 ENSMUSG00000074088.6; ENSMUSG00000106911.1 Snrnp40 4; CHR_MG4265_PATCH mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q6GT24 Peroxiredoxin-6 OS=Mus musculus OX=10090 GN=Prdx6 PE=1 SV=1 0 12.199 33 5 5 5 224 24.8 6.37 2 1 2 2 1 2 779389.7344 2013019.313 3358947.25 3 3 4 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;vacuole antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 11758 ENSMUSG00000026701.15 Prdx6 1 Neutrophil degranulation; Detoxification of Reactive Oxygen Species Metabolic pathways 0 High M0QWP1 Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 0 14.788 3 5 5 5 2034 216.5 6.15 1 2 2 1 2 2 1371091.781 2968162.656 3959918.625 3 5 4 cell communication;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;membrane enzyme regulator activity;metal ion binding;protein binding;transporter activity "Pf00008, Pf00050, Pf00053, Pf00054, Pf01390, Pf02210, Pf03137, Pf03146, Pf07648" 11603 ENSMUSG00000041936.18 Agrn 4 ECM-receptor interaction 0 High G3X9M0 "28S ribosomal protein S29, mitochondrial OS=Mus musculus OX=10090 GN=Dap3 PE=1 SV=1" 0 13.036 15 4 5 4 396 45.3 9.11 2 3 2 3 878857.8008 2601237.563 2852094.063 4 4 3 cell death;cell organization and biogenesis mitochondrion;organelle lumen;ribosome RNA binding;structural molecule activity "Pf05673, Pf10236" 65111 ENSMUSG00000068921.14 Dap3 3 0 High Q8R3X6 Glypican-6 OS=Mus musculus OX=10090 GN=Gpc6 PE=1 SV=1 0 12.014 7 3 5 2 565 64.3 5.67 1 1 3 1 1 3 184215.0469 459008.9375 1167513.625 1 1 2 cellular component movement extracellular;membrane;nucleus protein binding Pf01153 23888 ENSMUSG00000058571.10 Gpc6 14 0 High E9Q4F4 Small nuclear ribonucleoprotein E OS=Mus musculus OX=10090 GN=Snrpe PE=1 SV=1 0 16.407 40 2 5 2 91 10.9 8.48 1 2 2 1 2 2 6251832.625 2597699.25 2 1 metabolic process spliceosomal complex Pf01423 ENSMUSG00000090553.8 1 0 High P27773 Protein disulfide-isomerase A3 OS=Mus musculus OX=10090 GN=Pdia3 PE=1 SV=2 0 11.698 11 5 5 5 505 56.6 6.21 4 1 4 1 669421.1563 4022498.656 1785768.938 3 5 2 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endoplasmic reticulum;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding;RNA binding "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 14827 ENSMUSG00000027248.13 Pdia3 2 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle; ER-Phagosome pathway" Antigen processing and presentation; Protein processing in endoplasmic reticulum 0 Medium E9Q0B5 Fc fragment of IgG-binding protein OS=Mus musculus OX=10090 GN=Fcgbp PE=1 SV=1 0.023 1.859 0 1 4 1 2583 275 5.03 1 1 1 2 1 1 31212096 10114854 14114334 1 1 1 protein binding "Pf00094, Pf01826, Pf08742, Pf12714" ENSMUSG00000047730.17 7 0 High Q8R3N6 THO complex subunit 1 OS=Mus musculus OX=10090 GN=Thoc1 PE=1 SV=1 0 9.446 7 3 4 3 657 75.4 4.97 3 1 3 1 2654595.719 1610323.094 3 2 cell death;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00531, Pf11957" 225160 ENSMUSG00000024287.7 Thoc1 18 mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Spliceosome; RNA transport 0 High Q6P8N8 "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Mus musculus OX=10090 GN=Clpx PE=1 SV=1" 0 7.077 5 3 4 3 620 67.3 7.55 3 1 3 1 895314.3125 1074185.375 2 2 metabolic process;regulation of biological process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf00158, Pf01078, Pf05729, Pf07724, Pf07726, Pf07728, Pf10431, Pf13191, Pf13401, Pf14532" 270166 ENSMUSG00000015357.10 Clpx 9 0 High E9PXY8 Ubiquitin carboxyl-terminal hydrolase 7 OS=Mus musculus OX=10090 GN=Usp7 PE=1 SV=1 0 15.068 6 4 4 4 1143 132.8 5.66 1 3 1 3 306252.4688 536294 604483.1875 2 1 1 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00443, Pf00917, Pf12436, Pf13423, Pf14533" 252870 ENSMUSG00000022710.17 Usp7 16 Dual incision in TC-NER; Regulation of PTEN localization; Regulation of TP53 Degradation; Ub-specific processing proteases; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER; Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0 High Q05BE7 Numb protein OS=Mus musculus OX=10090 GN=Numb PE=1 SV=1 0 7.609 16 4 4 4 322 36.2 9.47 2 2 2 2 578632.7813 3826498.063 3059444.75 2 4 4 cell differentiation;cell division;cell organization and biogenesis;cell proliferation;development;regulation of biological process cytoplasm;endosome;membrane;nucleus protein binding "Pf00640, Pf06311, Pf08416" 18222 ENSMUSG00000021224.14 Numb 12 0 High P28660 Nck-associated protein 1 OS=Mus musculus OX=10090 GN=Nckap1 PE=1 SV=2 0 9.904 3 3 4 3 1128 128.7 6.62 2 2 2 2 249661.75 2094956.5 1688450.5 1 3 2 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;membrane protein binding Pf09735 50884 ENSMUSG00000027002.13 Nckap1 2 RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation Regulation of actin cytoskeleton 0 High Q9D0I9 "Arginine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Rars1 PE=1 SV=2" 0 7.885 5 3 4 3 660 75.6 7.55 3 1 3 1 190467.6719 2227273.406 2491315.625 1 3 3 metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00750, Pf03485, Pf05746" 104458 ENSMUSG00000018848.4 Rars 11 Aminoacyl-tRNA biosynthesis 0 High Q9D6J6 "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Mus musculus OX=10090 GN=Ndufv2 PE=1 SV=2" 0 9.911 18 3 4 3 248 27.3 7.4 1 2 1 3 319085.375 1665249.938 2107466.188 1 2 2 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding Pf01257 72900 ENSMUSG00000024099.14 Ndufv2 17 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q9CQ69 Cytochrome b-c1 complex subunit 8 OS=Mus musculus OX=10090 GN=Uqcrq PE=1 SV=3 0 4.6 24 2 4 2 82 9.8 10.26 1 1 2 1 1 2 806499.6875 1099108.25 1761395.938 2 2 2 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02939 22272 ENSMUSG00000044894.14 Uqcrq 11 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High D9J301 ENH isoform 1d OS=Mus musculus OX=10090 GN=Pdlim5 PE=1 SV=1 0 5.177 3 2 4 2 574 61.8 7.91 2 2 2 2 299417.7813 1683979.813 2195720 1 2 2 cell growth;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane metal ion binding;protein binding "Pf00412, Pf00595" 56376 ENSMUSG00000028273.15 Pdlim5 3 0 High Q64339 Ubiquitin-like protein ISG15 OS=Mus musculus OX=10090 GN=Isg15 PE=1 SV=4 0 13.563 11 1 4 1 161 17.9 7.9 1 1 2 2 1118641.625 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular protein binding "Pf00240, Pf11976" 100038882 ENSMUSG00000035692.6 Isg15 4 Termination of translesion DNA synthesis; ISG15 antiviral mechanism RIG-I-like receptor signaling pathway 0 High O88441 Metaxin-2 OS=Mus musculus OX=10090 GN=Mtx2 PE=1 SV=1 0 11.157 24 3 4 3 263 29.7 5.63 1 3 1 3 856431.1875 2018018.188 2 2 transport membrane;mitochondrion "Pf11801, Pf13410, Pf14497" 53375 ENSMUSG00000027099.9 Mtx2 2 0 High P12658 Calbindin OS=Mus musculus OX=10090 GN=Calb1 PE=1 SV=2 0 15.609 13 2 4 2 261 30 4.83 1 1 2 1 1 2 1151502.125 2265451.75 3494631.75 1 1 2 cellular homeostasis;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus metal ion binding "Pf00036, Pf13405, Pf13499" 12307 ENSMUSG00000028222.2 Calb1 4 Endocrine and other factor-regulated calcium reabsorption 0 High Q8BJY1 26S proteasome non-ATPase regulatory subunit 5 OS=Mus musculus OX=10090 GN=Psmd5 PE=1 SV=4 0 11.397 9 3 4 3 504 55.9 5.21 3 4 133164.9141 508606.8125 1567707.484 2 1 3 cell organization and biogenesis Pf10508 66998 ENSMUSG00000026869.12 Psmd5 2 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN 0 High Q80VQ1 Leucine-rich repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Lrrc1 PE=1 SV=2 0 15.487 10 3 4 2 524 59.4 5.16 1 3 1 3 654109.8281 1226679.625 2 2 regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding "Pf12799, Pf13855" 214345 ENSMUSG00000032352.16 Lrrc1 9 0 High P13707 "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Mus musculus OX=10090 GN=Gpd1 PE=1 SV=3" 0 7.325 22 4 4 4 349 37.5 7.17 1 3 1 3 1031314.129 2052493.313 4900735.875 3 3 4 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf01210, Pf07479" 14555 ENSMUSG00000023019.12 Gpd1 15 Synthesis of PA Glycerophospholipid metabolism 0 High Q9CPU4 Microsomal glutathione S-transferase 3 OS=Mus musculus OX=10090 GN=Mgst3 PE=1 SV=1 0 6.947 24 3 4 3 153 16.9 9.5 2 1 3 1 977653 1 metabolic process;response to stimulus endoplasmic reticulum;membrane antioxidant activity;catalytic activity Pf01124 66447 ENSMUSG00000026688.5 Mgst3 1 Glutathione conjugation; Aflatoxin activation and detoxification Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 High Q99KJ8 Dynactin subunit 2 OS=Mus musculus OX=10090 GN=Dctn2 PE=1 SV=3 0 9.171 12 3 4 3 402 44.1 5.26 1 3 1 3 50252.71875 409766.5313 3031398.188 1 1 3 cell organization and biogenesis;cell proliferation;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding Pf04912 69654 ENSMUSG00000025410.10 Dctn2 10 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR); COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation Huntington's disease; Vasopressin-regulated water reabsorption 0 High D3Z7C6 Prostaglandin E synthase 3 OS=Mus musculus OX=10090 GN=Ptges3 PE=1 SV=1 0 9.751 23 2 4 2 130 15 4.79 1 2 1 3 865987.3281 2249984.063 2 2 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus protein binding Pf04969 ENSMUSG00000071072.12 10 0 High P43276 Histone H1.5 OS=Mus musculus OX=10090 GN=H1-5 PE=1 SV=2 0 4.962 9 2 4 1 223 22.6 10.92 2 1 1 2 1 1 560982 835030.75 1858284.125 1 1 1 cell organization and biogenesis chromosome;nucleus DNA binding;protein binding Pf00538 56702 ENSMUSG00000058773.2 Hist1h1b 13 0 High P01878 Ig alpha chain C region OS=Mus musculus OX=10090 PE=1 SV=1 0 8.332 13 2 4 2 344 36.9 5.06 1 2 1 1 2 1 1207792 1861223 1 1 protein binding Pf07654 16061 Igh-VJ558 12 0 High Q8BP48 Methionine aminopeptidase 1 OS=Mus musculus OX=10090 GN=Metap1 PE=1 SV=1 0 9.251 12 3 4 3 386 43.2 7.17 1 3 1 3 4532376.5 2630242.094 3066767.813 2 3 3 metabolic process cytoplasm catalytic activity;metal ion binding Pf00557 75624 ENSMUSG00000005813.12 Metap1 3 "Inactivation, recovery and regulation of the phototransduction cascade; Signaling by GPCR" 0 High Q99L60 V-type proton ATPase subunit C 2 OS=Mus musculus OX=10090 GN=Atp6v1c2 PE=1 SV=1 0 15.753 12 4 4 4 427 48.3 6.76 2 2 2 2 1232732.313 1504018 2 2 regulation of biological process;transport membrane catalytic activity;protein binding;transporter activity Pf03223 68775 ENSMUSG00000020566.18 Atp6v1c2 12 "Ion channel transport; ROS, RNS production in phagocytes; Transferrin endocytosis and recycling; Insulin receptor recycling" mTOR signaling pathway; Rheumatoid arthritis; Metabolic pathways; Phagosome; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion 0 High P16332 "Methylmalonyl-CoA mutase, mitochondrial OS=Mus musculus OX=10090 GN=Mmut PE=1 SV=2" 0 8.102 8 3 4 3 748 82.8 6.89 1 3 1 3 250767.8594 1145729.938 1334184.313 2 2 2 metabolic process mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf01642, Pf02310" 17850 ENSMUSG00000023921.8 Mut 17 "Propionyl-CoA catabolism; Cobalamin (Cbl, vitamin B12) transport and metabolism" "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High O35682 Myeloid-associated differentiation marker OS=Mus musculus OX=10090 GN=Myadm PE=1 SV=2 0.003 3.671 8 2 4 2 320 35.3 8.31 2 1 2 2 3091139.125 4181933.063 6765599 2 2 2 cell organization and biogenesis;regulation of biological process cytoskeleton;membrane Pf01284 50918 ENSMUSG00000068566.12; ENSMUSG00000097829.2 Myadm 7; CHR_MG4151_PATCH 0 High O54962 Barrier-to-autointegration factor OS=Mus musculus OX=10090 GN=Banf1 PE=1 SV=1 0 9.952 43 3 4 3 89 10.1 6.09 2 2 2 2 974135.5313 2591907.75 2720857.75 2 3 2 metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;nucleus DNA binding;protein binding Pf02961 23825 ENSMUSG00000024844.14 Banf1 19 Clearance of Nuclear Envelope Membranes from Chromatin; Initiation of Nuclear Envelope Reformation; Nuclear Envelope Breakdown 0 High Q9CPP6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Mus musculus OX=10090 GN=Ndufa5 PE=1 SV=3 0 6.912 28 3 4 3 116 13.4 8.1 1 3 1 3 1841831.672 3207952.313 1586286.5 3 3 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity Pf04716 68202 ENSMUSG00000023089.12 Ndufa5 6 Complex I biogenesis 0 High P60766 Cell division control protein 42 homolog OS=Mus musculus OX=10090 GN=Cdc42 PE=1 SV=2 0 12.589 21 3 4 3 191 21.2 6.55 2 2 2 2 299274.9063 6537388.438 6743692.875 1 3 3 cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf08477" 12540 ENSMUSG00000006699.17 Cdc42 4 RHO GTPases activate KTN1; EGFR downregulation; VEGFA-VEGFR2 Pathway; CD28 dependent Vav1 pathway; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs; RHO GTPases activate IQGAPs; Rho GTPase cycle; Mitotic Prometaphase; RHO GTPases Activate Formins; RHO GTPases Activate WASPs and WAVEs; DCC mediated attractive signaling; Factors involved in megakaryocyte development and platelet production; EPHB-mediated forward signaling; CDO in myogenesis Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; Endocytosis; T cell receptor signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Ras signaling pathway; VEGF signaling pathway; Focal adhesion; Chemokine signaling pathway; Axon guidance; Adherens junction; Non-alcoholic fatty liver disease (NAFLD); Proteoglycans in cancer; Salmonella infection; Fc gamma R-mediated phagocytosis; Neurotrophin signaling pathway; Rap1 signaling pathway; Pathways in cancer; Pancreatic cancer; Renal cell carcinoma; GnRH signaling pathway; Tight junction; Viral carcinogenesis; Bacterial invasion of epithelial cells 0 High Q561M1 Acp1 protein OS=Mus musculus OX=10090 GN=Acp1 PE=1 SV=1 0 7.87 13 2 4 2 158 17.9 6.54 1 1 2 1 1 2 1423478 5121375.5 6351969.25 2 2 2 metabolic process cytoplasm;cytosol;membrane catalytic activity Pf01451 11431 ENSMUSG00000044573.15 Acp1 12 Thiamine metabolism; Metabolic pathways; Adherens junction 0 High Q99L13 "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Hibadh PE=1 SV=1" 0 5.602 9 2 4 2 335 35.4 8.13 1 1 2 1 1 2 516157.8125 872934.0625 1475061.094 2 1 2 metabolic process;transport mitochondrion catalytic activity;nucleotide binding "Pf02254, Pf02826, Pf03446, Pf03807, Pf14833" 58875 ENSMUSG00000029776.11 Hibadh 6 Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways" 0 High Q8CG71 Prolyl 3-hydroxylase 2 OS=Mus musculus OX=10090 GN=P3h2 PE=1 SV=1 0 7.128 4 3 4 3 703 80.1 5.85 3 1 3 1 3065951.063 558407.5 3 2 metabolic process;regulation of biological process endoplasmic reticulum;Golgi catalytic activity;metal ion binding;protein binding "Pf09859, Pf13640, Pf13661, Pf14853" 210530 ENSMUSG00000038168.5 Leprel1; P3h2 16 Collagen biosynthesis and modifying enzymes 0 High Q62172 RalA-binding protein 1 OS=Mus musculus OX=10090 GN=Ralbp1 PE=1 SV=4 0 4.769 7 3 4 3 648 75 5.92 3 1 3 1 297176.0781 1355320.125 1417897.688 2 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport membrane catalytic activity;enzyme regulator activity;protein binding;transporter activity Pf00620 19765 ENSMUSG00000024096.16 Ralbp1 17 Rho GTPase cycle Ras signaling pathway; Pathways in cancer; Pancreatic cancer 0 High E9PXP7 Stonin-2 OS=Mus musculus OX=10090 GN=Ston2 PE=1 SV=1 0 8.813 8 4 4 4 898 99.8 5.48 2 2 2 2 479821.9063 377999.5625 620817.375 1 1 1 regulation of biological process;transport "Pf00928, Pf12016" ENSMUSG00000020961.14 12 0 High E9Q1S3 Protein transport protein SEC23 OS=Mus musculus OX=10090 GN=Sec23a PE=1 SV=1 0 16.588 4 2 4 2 736 82.9 7.46 2 2 2 2 538116.375 1764427.438 1448896.75 1 2 2 transport cytoplasm;membrane metal ion binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" ENSMUSG00000020986.13 12 0 High A0A1B0GSR9 L-lactate dehydrogenase OS=Mus musculus OX=10090 GN=Ldha PE=1 SV=1 0 11.686 12 3 4 3 315 34.6 8.56 3 1 3 1 1041298.531 2689338.375 2824312.063 2 3 3 metabolic process cytoplasm catalytic activity "Pf00056, Pf02866" ENSMUSG00000063229.15 7 0 High P70290 55 kDa erythrocyte membrane protein OS=Mus musculus OX=10090 GN=Mpp1 PE=1 SV=1 0 8.223 9 3 4 3 466 52.2 7.2 2 2 2 2 769845.0469 2156461 3544364.188 2 2 3 regulation of biological process cytoskeleton;membrane protein binding "Pf00018, Pf00595, Pf00625, Pf07653, Pf13180, Pf14604" 17524 ENSMUSG00000031402.12 Mpp1 X 0 High O35632 Hyaluronidase-2 OS=Mus musculus OX=10090 GN=Hyal2 PE=1 SV=2 0 5.918 11 2 4 2 473 53.6 7.71 2 1 2 2 1971826.188 1410573 2 1 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;membrane;vacuole catalytic activity;enzyme regulator activity;protein binding;receptor activity Pf01630 15587 ENSMUSG00000010047.12 Hyal2 9 Hyaluronan uptake and degradation Metabolic pathways; Glycosaminoglycan degradation 0 High A0A2I3BPG9 "Ribosomal protein L36A, pseudogene 1 OS=Mus musculus OX=10090 GN=Rpl36a-ps1 PE=3 SV=1" 0 5.125 25 3 4 3 106 12.4 10.51 1 3 1 3 1893774.125 6476887.438 2891809.25 2 3 1 0 High P09103 Protein disulfide-isomerase OS=Mus musculus OX=10090 GN=P4hb PE=1 SV=2 0 12.265 11 4 4 4 509 57 4.88 2 2 2 2 944183.5234 3826720.188 4965654.688 4 4 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13899, Pf13905" 18453 ENSMUSG00000025130.11 P4hb 11 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Detoxification of Reactive Oxygen Species; Chylomicron assembly; Interleukin-12 family signaling; VLDL assembly; Hedgehog ligand biogenesis; Collagen biosynthesis and modifying enzymes Protein processing in endoplasmic reticulum 0 Medium Q8BGQ7 "Alanine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Aars1 PE=1 SV=1" 0.035 1.603 1 1 4 1 968 106.8 5.67 1 1 3 1 3157642.75 16648177 21230864 1 1 1 Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf01411, Pf02272, Pf07973" 234734 ENSMUSG00000031960.14 Aars 8 Aminoacyl-tRNA biosynthesis 0 High Q9CPX7 "28S ribosomal protein S16, mitochondrial OS=Mus musculus OX=10090 GN=Mrps16 PE=1 SV=1" 0 5.255 19 2 4 2 135 15.2 9.67 1 1 2 1 1 2 762249.75 1454282 2199409.25 2 2 2 cell organization and biogenesis;metabolic process cytosol;mitochondrion;ribosome structural molecule activity Pf00886 66242 ENSMUSG00000049960.3 Mrps16 14 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High A0A2I3BQ16 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus OX=10090 GN=Lrch1 PE=1 SV=1 0 13.833 7 4 4 3 682 76 6.09 1 2 1 1 2 1 247425.9531 2274153.781 1743279.656 1 2 2 0 High Q91VH2 Sorting nexin-9 OS=Mus musculus OX=10090 GN=Snx9 PE=1 SV=1 0 10.08 7 4 4 4 595 66.5 5.52 3 1 3 1 812657.4375 1937610.188 637268.75 3 3 1 cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane protein binding "Pf00018, Pf00787, Pf07653, Pf10456, Pf14604" 66616 ENSMUSG00000002365.9 Snx9 17 Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis 0 High A0A0A6YW28 Ubiquitin carboxyl-terminal hydrolase OS=Mus musculus OX=10090 GN=Usp4 PE=1 SV=1 0 10.952 7 3 4 3 915 103.7 5.48 3 1 3 1 94927.61719 660009.75 966510.25 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00443, Pf06337, Pf13423, Pf14836" 22258 ENSMUSG00000032612.14 Usp4 9 0 High Q9CXZ1 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs4 PE=1 SV=3" 0 7.326 14 2 4 2 175 19.8 9.99 2 1 3 1 1145233.328 2740370.5 3640816.75 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity Pf04800 17993 Ndufs4 13 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q8K370 Acyl-CoA dehydrogenase family member 10 OS=Mus musculus OX=10090 GN=Acad10 PE=1 SV=1 0 12.748 6 4 4 4 1069 118.9 8.24 1 3 1 3 724649.25 7843292.688 14431862.13 1 3 4 metabolic process mitochondrion catalytic activity;nucleotide binding "Pf00441, Pf00702, Pf01163, Pf01636, Pf02770, Pf02771, Pf08028, Pf13419" 71985 ENSMUSG00000029456.12 Acad10 5 Mitochondrial Fatty Acid Beta-Oxidation 0 High P61922 "4-aminobutyrate aminotransferase, mitochondrial OS=Mus musculus OX=10090 GN=Abat PE=1 SV=1" 0 10.416 8 3 4 3 500 56.4 8.09 2 2 2 2 802903.5469 2407139.875 1590233.875 2 2 2 metabolic process;regulation of biological process;response to stimulus mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00202, Pf13481" 268860 ENSMUSG00000057880.12 Abat 16 Degradation of GABA "GABAergic synapse; Valine, leucine and isoleucine degradation; Metabolic pathways; Butanoate metabolism; beta-Alanine metabolism; Propanoate metabolism; Alanine, aspartate and glutamate metabolism" 0 High Q8BU30 "Isoleucine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Iars1 PE=1 SV=2" 0 5.163 2 2 4 2 1262 144.2 6.55 2 2 2 2 2277955.688 2561599.125 2 2 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00133, Pf01406, Pf08264, Pf09334" 105148 ENSMUSG00000037851.13 Iars 13 Aminoacyl-tRNA biosynthesis 0 High Q99JB7 Protein amnionless OS=Mus musculus OX=10090 GN=Amn PE=1 SV=1 0 9.515 13 4 4 4 458 48.7 5.55 2 1 1 2 1 1 2126070.531 2313874.406 2478197.25 3 3 2 cell organization and biogenesis;development;transport endosome;membrane protein binding Pf14828 93835 ENSMUSG00000021278.6 Amn 12 "Cobalamin (Cbl, vitamin B12) transport and metabolism; HDL clearance" 0 High Q80SY5 Pre-mRNA-splicing factor 38B OS=Mus musculus OX=10090 GN=Prpf38b PE=1 SV=1 0 10.629 8 4 4 4 542 63.7 10.54 4 4 2331820.125 1510644.125 2 1 metabolic process nucleus;spliceosomal complex RNA binding Pf03371 66921 ENSMUSG00000027881.14 Prpf38b 3 Spliceosome 0 High Q9WUA2 Phenylalanine--tRNA ligase beta subunit OS=Mus musculus OX=10090 GN=Farsb PE=1 SV=2 0 8.524 5 3 4 3 589 65.7 7.12 1 2 1 1 2 1 480164.5938 462741.2813 1 1 cell organization and biogenesis;metabolic process cytoplasm;membrane catalytic activity;metal ion binding;nucleotide binding;RNA binding "Pf03483, Pf03484" 23874 ENSMUSG00000026245.16 Farsb 1 Aminoacyl-tRNA biosynthesis 0 High O70165 Ficolin-1 OS=Mus musculus OX=10090 GN=Fcn1 PE=1 SV=1 0 9.532 8 2 4 2 334 36.3 6.52 1 2 1 1 2 1 950508.9219 1545736 2006285.5 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00147, Pf01391, Pf14513" 14133 ENSMUSG00000026938.10 Fcna 2 0 High Q505D1 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus OX=10090 GN=Ankrd28 PE=1 SV=1 0 7.339 4 3 4 3 1053 112.8 6.27 2 2 2 2 241730.8594 1055581.906 1814914.438 2 3 3 nucleus protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 105522 ENSMUSG00000014496.7 Ankrd28 14 COPII (Coat Protein 2) Mediated Vesicle Transport 0 High Q91WS0 CDGSH iron-sulfur domain-containing protein 1 OS=Mus musculus OX=10090 GN=Cisd1 PE=1 SV=1 0 6.075 31 3 4 3 108 12.1 9.06 1 2 1 3 832751.5156 2973319.094 3621412.875 3 3 3 regulation of biological process membrane;mitochondrion metal ion binding;protein binding Pf09360 52637 ENSMUSG00000037710.8 Cisd1 10 0 High P08207 Protein S100-A10 OS=Mus musculus OX=10090 GN=S100a10 PE=1 SV=2 0 12.344 36 2 4 2 97 11.2 6.77 1 1 2 1 1 2 2399023.688 3601813 755490.625 2 2 1 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;membrane metal ion binding;protein binding Pf01023 20194 ENSMUSG00000041959.14 S100a10 3 Dissolution of Fibrin Clot 0 High D3Z132 THO complex subunit 6 homolog OS=Mus musculus OX=10090 GN=Thoc6 PE=1 SV=1 0 8.398 12 3 4 3 337 37.1 7.65 3 1 3 1 63237.89844 1366139.625 1986758.188 1 2 2 protein binding Pf00400 ENSMUSG00000041319.13 17 0 High Q9QYB1 Chloride intracellular channel protein 4 OS=Mus musculus OX=10090 GN=Clic4 PE=1 SV=3 0 10.291 13 2 4 2 253 28.7 5.59 2 2 2 2 1337618.758 2272235.313 2564135.75 2 2 2 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity "Pf00043, Pf13409, Pf13410, Pf13417, Pf14497" 29876 ENSMUSG00000037242.8 Clic4 4 0 High P14152 "Malate dehydrogenase, cytoplasmic OS=Mus musculus OX=10090 GN=Mdh1 PE=1 SV=3" 0 7.711 12 3 4 3 334 36.5 6.58 1 2 1 1 2 1 555484.5 1594735.25 2008761.313 1 2 2 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding "Pf00056, Pf02866" 17449 ENSMUSG00000020321.15 Mdh1 11 Gluconeogenesis Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Cysteine and methionine metabolism; Proximal tubule bicarbonate reclamation; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High P16125 L-lactate dehydrogenase B chain OS=Mus musculus OX=10090 GN=Ldhb PE=1 SV=2 0 9.981 10 3 4 3 334 36.5 6.05 1 2 1 1 2 1 1734257.063 3201643.5 4940623 2 2 2 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 16832 ENSMUSG00000030246.11 Ldhb 6 Pyruvate metabolism Pyruvate metabolism; Metabolic pathways; Cysteine and methionine metabolism; Glycolysis / Gluconeogenesis; Propanoate metabolism; Glucagon signaling pathway 0 High Q9D5V5 Cullin-5 OS=Mus musculus OX=10090 GN=Cul5 PE=1 SV=3 0 9.921 7 3 4 3 780 90.9 7.81 2 2 2 2 151581.6719 851341.0313 1600643.375 1 2 3 cellular component movement;cellular homeostasis;metabolic process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;protein binding "Pf00888, Pf10557" 75717 Cul5 9 Ubiquitin mediated proteolysis 0 High P52623 Uridine-cytidine kinase 1 OS=Mus musculus OX=10090 GN=Uck1 PE=1 SV=2 0 10.561 21 4 4 4 277 31 7.88 1 3 1 3 374266.2188 3058168.328 4898772.25 2 4 4 metabolic process cytosol catalytic activity;nucleotide binding "Pf00485, Pf13207, Pf13238" 22245 Uck1 2 Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High P29699 Alpha-2-HS-glycoprotein OS=Mus musculus OX=10090 GN=Ahsg PE=1 SV=1 0 16.445 20 3 4 3 345 37.3 6.51 3 1 3 1 2843808 1217627.625 1 1 cell organization and biogenesis;defense response;regulation of biological process;response to stimulus extracellular;Golgi enzyme regulator activity Pf00031 11625 ENSMUSG00000022868.5 Ahsg 16 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Platelet degranulation ; Neutrophil degranulation; Post-translational protein phosphorylation 0 High Q8VCW8 "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Mus musculus OX=10090 GN=Acsf2 PE=1 SV=1" 0 6.982 4 2 4 2 615 67.9 8.18 2 2 2 2 629643.25 1326124.406 2220541.188 1 2 2 metabolic process mitochondrion catalytic activity;nucleotide binding "Pf00501, Pf13193" 264895 ENSMUSG00000076435.3 Acsf2 11 Mitochondrial Fatty Acid Beta-Oxidation 0 High Q8BKH7 Target of rapamycin complex 2 subunit MAPKAP1 OS=Mus musculus OX=10090 GN=Mapkap1 PE=1 SV=1 0 12.808 9 4 4 4 522 59 7.53 1 3 1 3 432405.25 1663480.25 1 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;membrane;nucleus protein binding Pf05422 227743 ENSMUSG00000038696.14 Mapkap1 2 PIP3 activates AKT signaling; VEGFR2 mediated vascular permeability; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation mTOR signaling pathway 0 High O35206 Collagen alpha-1(XV) chain OS=Mus musculus OX=10090 GN=Col15a1 PE=1 SV=2 0 9.248 3 3 4 3 1367 140.4 4.89 1 1 1 2 1 1 1048127.938 537919 1 1 extracellular structural molecule activity "Pf01391, Pf06482, Pf13385" 12819 ENSMUSG00000028339.17 Col15a1 4 Collagen chain trimerization; Collagen degradation Protein digestion and absorption 0 High Q9WU78 Programmed cell death 6-interacting protein OS=Mus musculus OX=10090 GN=Pdcd6ip PE=1 SV=3 0 10.799 5 3 4 3 869 96 6.52 1 3 1 3 870836.9375 2176379.563 2 3 cell death;cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane protein binding "Pf03097, Pf08391, Pf13949" 18571 ENSMUSG00000032504.15 Pdcd6ip 9 Endocytosis 0 High Q14C51 "Pentatricopeptide repeat domain-containing protein 3, mitochondrial OS=Mus musculus OX=10090 GN=Ptcd3 PE=1 SV=2" 0 18.225 5 3 4 3 685 77.7 5.88 1 3 1 3 483479.9531 1734424.281 2097609.688 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane;mitochondrion;ribosome RNA binding "Pf12854, Pf13041" 69956 ENSMUSG00000063884.6 Ptcd3 6 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q3UKJ7 WD40 repeat-containing protein SMU1 OS=Mus musculus OX=10090 GN=Smu1 PE=2 SV=2 0.002 4.14 4 2 4 2 513 57.5 7.18 2 1 3 1 1341581.563 1048361 2 1 metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex protein binding Pf00400 74255 ENSMUSG00000028409.11 Smu1 4 0 High Q7TNV0 Protein DEK OS=Mus musculus OX=10090 GN=Dek PE=1 SV=1 0 5.028 7 2 4 2 380 43.1 6.86 1 1 2 1 1 2 511051.4688 876962.75 996542.125 1 1 1 cell organization and biogenesis;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf02037, Pf08766" 110052 ENSMUSG00000021377.14 Dek 13 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; B-WICH complex positively regulates rRNA expression 0 High A0A1W2P845 Cysteine and glycine-rich protein 2 OS=Mus musculus OX=10090 GN=Csrp2 PE=1 SV=1 0 9.806 20 3 4 3 197 21.6 8.78 1 3 1 3 3094245.969 5375576.25 8155239.25 3 3 2 cell differentiation;development nucleus metal ion binding;protein binding Pf00412 13008 ENSMUSG00000020186.7 Csrp2 10 0 High P11103 Poly [ADP-ribose] polymerase 1 OS=Mus musculus OX=10090 GN=Parp1 PE=1 SV=3 0 7.77 3 3 4 3 1013 113 8.95 2 2 2 2 4433248.625 13200552.31 8743407.813 3 3 3 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063" 11545 Parp1 1 0 High A0A0B4J1H8 Immunoglobulin kappa variable 1-133 (Fragment) OS=Mus musculus OX=10090 GN=Igkv1-133 PE=4 SV=1 0 9.865 29 3 4 3 120 13.2 7.97 2 2 2 2 1880111.359 3577707.25 3 3 response to stimulus Pf07686 434023 ENSMUSG00000094491.2 Bj2 6 0 High P61514 60S ribosomal protein L37a OS=Mus musculus OX=10090 GN=Rpl37a PE=1 SV=2 0.002 4.119 22 2 4 2 92 10.3 10.43 2 1 1 2 1 1 1546474.125 1997831 3212153.813 2 2 2 metabolic process nucleus;ribosome metal ion binding;RNA binding;structural molecule activity Pf01780 19981 ENSMUSG00000046330.10 Rpl37a 1 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8CBW3 Abl interactor 1 OS=Mus musculus OX=10090 GN=Abi1 PE=1 SV=3 0 10.182 7 2 4 2 481 52.3 7.64 1 1 2 1 1 2 252980.6563 1487625.859 1399283.406 1 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus enzyme regulator activity;protein binding "Pf00018, Pf07653, Pf07815, Pf14604" 11308 ENSMUSG00000058835.14 Abi1 2 RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation 0 High O70200 Allograft inflammatory factor 1 OS=Mus musculus OX=10090 GN=Aif1 PE=1 SV=1 0 5.187 16 2 4 2 147 16.9 8.76 2 2 2 2 1183742.656 5731978.25 9410744.75 2 2 2 cell communication;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus metal ion binding;protein binding Pf13499 11629 ENSMUSG00000024397.14 Aif1 17 0 High O88335 ATP-sensitive inward rectifier potassium channel 1 OS=Mus musculus OX=10090 GN=Kcnj1 PE=2 SV=1 0 7.354 9 3 4 3 372 42.7 8.66 3 1 3 1 1262543.406 2856417.5 2540667.75 3 3 3 regulation of biological process;response to stimulus;transport membrane metal ion binding;nucleotide binding;transporter activity Pf01007 56379 ENSMUSG00000041248.9 Kcnj1 9 Potassium transport channels Gastric acid secretion; Aldosterone-regulated sodium reabsorption 0 High P22315 "Ferrochelatase, mitochondrial OS=Mus musculus OX=10090 GN=Fech PE=1 SV=2" 0 5.469 11 3 4 3 420 47.1 8.91 3 4 1121733.703 2490990.938 3348617 3 3 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;metal ion binding;protein binding;RNA binding Pf00762 14151 Fech 18 0 High Q8BH64 EH domain-containing protein 2 OS=Mus musculus OX=10090 GN=Ehd2 PE=1 SV=1 0 7.327 7 3 4 2 543 61.1 6.51 1 3 1 3 372049.8281 840309.3438 1251922.094 2 2 2 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 259300 ENSMUSG00000074364.6 Ehd2 7 Factors involved in megakaryocyte development and platelet production Endocytosis 0 High Q9NYQ2 Hydroxyacid oxidase 2 OS=Mus musculus OX=10090 GN=Hao2 PE=1 SV=1 0 10.174 9 3 4 3 353 38.7 7.64 2 2 2 2 1119045.125 3415130.5 5808707.25 3 3 3 cell organization and biogenesis;metabolic process mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00478, Pf01070, Pf01645" 56185 ENSMUSG00000027870.8 Hao2 3 Peroxisomal lipid metabolism Metabolic pathways; Carbon metabolism; Glyoxylate and dicarboxylate metabolism; Peroxisome 0 High Q5U430 E3 ubiquitin-protein ligase UBR3 OS=Mus musculus OX=10090 GN=Ubr3 PE=1 SV=3 0 9.83 2 3 4 3 1889 212.6 5.9 1 3 1 3 1174120 1 metabolic process;response to stimulus cytoplasm;membrane catalytic activity;metal ion binding;protein binding Pf02207 68795 ENSMUSG00000044308.17 Ubr3 2 0 High Q3UJB0 "Splicing factor 3b, subunit 2 OS=Mus musculus OX=10090 GN=Sf3b2 PE=1 SV=1" 0.002 4.13 2 2 4 2 878 98.1 5.62 2 2 2 2 1108101.563 2534447.625 2 2 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf02037, Pf04037, Pf04046" 319322 ENSMUSG00000024853.9 Sf3b2 19 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High J3JS84 "G protein-coupled receptor, family C, group 5, member C OS=Mus musculus OX=10090 GN=Gprc5c PE=1 SV=1" 0.002 3.883 6 2 4 2 440 48.4 7.64 2 1 2 2 892779.9063 2852088.063 2162112 2 2 1 regulation of biological process;response to stimulus membrane;mitochondrion protein binding;receptor activity;signal transducer activity Pf00003 70355 ENSMUSG00000051043.16 Gprc5c 11 0 High Q3TEA8 Heterochromatin protein 1-binding protein 3 OS=Mus musculus OX=10090 GN=Hp1bp3 PE=1 SV=1 0 10.789 10 4 4 4 554 60.8 9.7 4 4 893938.1563 2416061.625 4328913.875 3 4 4 cell organization and biogenesis;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf00538 15441 ENSMUSG00000028759.13 Hp1bp3 4 0 High Q921I1 Serotransferrin OS=Mus musculus OX=10090 GN=Tf PE=1 SV=1 0 12.736 6 3 4 3 697 76.7 7.18 3 4 823072.3438 2 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endosome;extracellular;membrane metal ion binding;protein binding;transporter activity "Pf00405, Pf12974" 22041 ENSMUSG00000032554.15 Trf 9 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling Mineral absorption; HIF-1 signaling pathway 0 Medium Q9DBM1 G patch domain-containing protein 1 OS=Mus musculus OX=10090 GN=Gpatch1 PE=2 SV=1 0.038 1.551 1 1 4 1 930 102.9 6.98 1 1 1 1 1 2 19691198 312544320 428952384 1 1 1 metabolic process spliceosomal complex "Pf01585, Pf07713" 67471 ENSMUSG00000063808.14 Gpatch1 7 0 High A2AFQ2 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Mus musculus OX=10090 GN=Hsd17b10 PE=1 SV=1 0 12.273 14 2 4 2 271 28.4 8.76 2 1 3 1 2892629.688 3690752.094 5547865.063 2 2 2 cell organization and biogenesis;metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf08659, Pf13561" 15108 ENSMUSG00000025260.10 Hsd17b10 X Branched-chain amino acid catabolism 0 High Q9D1Q6 Endoplasmic reticulum resident protein 44 OS=Mus musculus OX=10090 GN=Erp44 PE=1 SV=1 0 12.248 18 4 4 4 406 46.8 5.27 1 1 2 1 1 2 119959.3359 354338.8438 2025653.938 1 2 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00085, Pf01216, Pf07449, Pf13098, Pf13848" 76299 ENSMUSG00000028343.10 Erp44 4 Neutrophil degranulation 0 High A0A0A6YYE7 Immunoglobulin kappa variable 4-57 (Fragment) OS=Mus musculus OX=10090 GN=Igkv4-57 PE=4 SV=2 0 10.81 27 2 4 2 117 12.7 8.91 1 1 2 1 1 2 969688.9375 1213771.531 3270144.5 1 2 2 response to stimulus "Pf00047, Pf07686" 235952 ENSMUSG00000076556.3 Igkv4-57 6 0 High Q9D0F4 NF-kappa-B-activating protein OS=Mus musculus OX=10090 GN=Nkap PE=2 SV=1 0.003 3.256 4 1 4 1 415 47.2 10.13 1 1 1 2 1 1 1064549.5 656722.125 1001169.063 1 1 1 cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus DNA binding;RNA binding Pf06047 67050 ENSMUSG00000016409.4 Nkap X 0 High G3X9L9 Myomegalin OS=Mus musculus OX=10090 GN=Pde4dip PE=1 SV=1 0 10.389 1 2 3 2 2463 277.3 5.53 2 1 2 1 671613.75 3111273.5 3749383.5 1 1 1 cell organization and biogenesis cytoplasm;cytoskeleton;Golgi;nucleus protein binding "Pf06758, Pf07851, Pf07989, Pf12128" 83679 ENSMUSG00000038170.15 Pde4dip 3 0 High D3Z5T4 Rho GTPase-activating protein 24 OS=Mus musculus OX=10090 GN=Arhgap24 PE=1 SV=1 0 15.364 5 2 3 2 657 73.5 8.16 1 1 1 1 1 1 1689750.625 1 cell differentiation;cellular component movement;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton enzyme regulator activity "Pf00620, Pf12718" 231532 ENSMUSG00000057315.14 Arhgap24 5 0 Low Q3ZAS0 Sodium/hydrogen exchanger OS=Mus musculus OX=10090 GN=Slc9a2 PE=1 SV=1 0.084 1.27 1 1 3 1 814 91.6 9.45 1 1 1 2 193800.0313 867056.625 3424623 1 1 1 cellular homeostasis;transport membrane transporter activity Pf00999 226999 ENSMUSG00000026062.12 Slc9a2 1 Sodium/Proton exchangers 0 High O35988 Syndecan-4 OS=Mus musculus OX=10090 GN=Sdc4 PE=1 SV=1 0 5.469 7 1 3 1 198 21.5 4.41 1 1 1 1 1 1 2663457.25 4506462 2848007.5 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;extracellular;membrane;organelle lumen protein binding;receptor activity;signal transducer activity Pf01034 20971 ENSMUSG00000017009.3 Sdc4 2 HS-GAG degradation; A tetrasaccharide linker sequence is required for GAG synthesis; Cell surface interactions at the vascular wall; Signaling by GPCR; Retinoid metabolism and transport; HS-GAG biosynthesis; Syndecan interactions Cell adhesion molecules (CAMs); Proteoglycans in cancer; ECM-receptor interaction 0 High Q8BVQ9 26S proteasome regulatory subunit 7 OS=Mus musculus OX=10090 GN=Psmc2 PE=1 SV=1 0.002 3.882 4 2 3 2 475 52.8 6.28 1 2 1 2 106269.2031 764009.4375 1441567.188 1 2 2 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00158, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 19181 ENSMUSG00000028932.7 Psmc2 5 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 Low G3UYQ4 Adenylate kinase 9 OS=Mus musculus OX=10090 GN=Ak9 PE=1 SV=2 0.054 1.412 0 1 3 1 1894 219.4 5.19 1 1 2 1 1246896 1381522.75 1987901.375 1 1 1 metabolic process cytoplasm;membrane;nucleus catalytic activity;nucleotide binding "Pf00004, Pf00406, Pf12018, Pf13207, Pf13238, Pf13671" ENSMUSG00000091415.5 10 Interconversion of nucleotide di- and triphosphates 0 High A0A0R4J0I6 Acyl-CoA dehydrogenase family member 11 OS=Mus musculus OX=10090 GN=Acad11 PE=1 SV=1 0 6.446 5 3 3 3 779 87.3 8.43 3 3 277705.4375 1487376.938 3654461.313 1 2 3 metabolic process membrane;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00441, Pf01636, Pf02770, Pf02771, Pf08028" 102632 ENSMUSG00000090150.10 Acad11 9 Mitochondrial Fatty Acid Beta-Oxidation 0 High F6QPR1 Prohibitin (Fragment) OS=Mus musculus OX=10090 GN=Phb2 PE=1 SV=1 0.004 3.092 12 2 3 2 157 17.5 9.8 1 1 1 2 124639.1094 1016723.625 1920135 1 2 2 membrane Pf01145 ENSMUSG00000004264.17 6 0 High O55029 Coatomer subunit beta' OS=Mus musculus OX=10090 GN=Copb2 PE=1 SV=2 0 7.576 6 3 3 3 905 102.4 5.3 2 1 2 1 6187782.375 1509701.859 2059420.75 2 3 3 transport cytoplasm;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053" 50797 ENSMUSG00000032458.6 Copb2 9 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q9JI95 CPN10-like protein OS=Mus musculus OX=10090 GN=Hspe1-rs1 PE=3 SV=1 0 5.509 24 2 3 2 102 11 8.92 1 1 1 1 1 1 571756.7344 1241816.813 2885089.188 2 2 2 metabolic process cytoplasm Pf00166 628438 Hspe1-rs1 18 0 High Q9R0P3 S-formylglutathione hydrolase OS=Mus musculus OX=10090 GN=Esd PE=1 SV=1 0 7.167 13 3 3 3 282 31.3 7.12 2 1 2 1 2620441.375 2490729.875 3383877.625 3 3 3 metabolic process cytoplasm catalytic activity;protein binding "Pf00326, Pf00756, Pf05448, Pf12695, Pf12697" 13885 ENSMUSG00000021996.16 Esd 14 Glutathione conjugation Carbon metabolism 0 High O70433 Four and a half LIM domains protein 2 OS=Mus musculus OX=10090 GN=Fhl2 PE=1 SV=1 0 6.225 13 3 3 3 279 32.1 7.3 3 3 846932.3125 1753979.563 2696592.188 2 2 3 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus metal ion binding;protein binding Pf00412 14200 ENSMUSG00000008136.14 Fhl2 1 Osteoclast differentiation 0 High D3Z1Y1 E3 ubiquitin-protein ligase synoviolin OS=Mus musculus OX=10090 GN=Syvn1 PE=1 SV=1 0 5.359 4 2 3 2 608 66.9 7.08 1 2 1 2 1158578.25 2504097.75 1 1 metabolic process membrane catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" ENSMUSG00000024807.17 19 Hedgehog ligand biogenesis; ER Quality Control Compartment (ERQC) 0 High P99028 "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Mus musculus OX=10090 GN=Uqcrh PE=1 SV=2" 0 7.025 20 1 3 1 89 10.4 4.87 1 1 1 1 1 1 949707.3125 3062628 3515169.75 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf02320 66576 ENSMUSG00000063882.12 Uqcrh 4 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q921M3 Splicing factor 3B subunit 3 OS=Mus musculus OX=10090 GN=Sf3b3 PE=1 SV=1 0 9.413 2 2 3 2 1217 135.5 5.26 1 2 1 2 3007888.25 3038593.625 2 2 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf03178, Pf10433" 101943 ENSMUSG00000033732.10 Sf3b3 8 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9QYJ0 DnaJ homolog subfamily A member 2 OS=Mus musculus OX=10090 GN=Dnaja2 PE=1 SV=1 0 8.18 10 2 3 2 412 45.7 6.48 2 1 2 1 356103.9375 1305871.875 1753198.375 1 2 2 metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 56445 ENSMUSG00000031701.6 Dnaja2 8 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High E9Q6A6 Collagen alpha-6(VI) chain OS=Mus musculus OX=10090 GN=Col6a6 PE=1 SV=2 0 9.77 2 3 3 3 2265 246.3 6.9 1 2 1 2 472876.3125 646115.4375 1 1 extracellular "Pf00092, Pf01391, Pf03363, Pf13519" ENSMUSG00000043719.14 9 0 High Q80VP1 Epsin-1 OS=Mus musculus OX=10090 GN=Epn1 PE=1 SV=3 0.004 3.073 3 2 3 2 575 60.2 4.81 2 1 2 1 1079531.219 1289301.031 780504.125 2 2 1 regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus protein binding Pf01417 13854 ENSMUSG00000035203.16 Epn1 7 Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation Endocytosis 0 High A0A0G2JFA8 Immunoglobulin kappa variable 17-121 (Fragment) OS=Mus musculus OX=10090 GN=Igkv17-121 PE=4 SV=4 0.009 2.898 14 1 3 1 117 12.9 4.36 1 1 1 1 1 1 3165191.75 1478565.375 2760666.75 1 1 1 response to stimulus "Pf00047, Pf07686" 667435 ENSMUSG00000076514.3 Igkv17-121 6 0 Low Q45VK7 Cytoplasmic dynein 2 heavy chain 1 OS=Mus musculus OX=10090 GN=Dync2h1 PE=1 SV=1 0.079 1.296 0 1 3 1 4306 492 6.6 1 1 1 2 30172618 30317122 12811689 1 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00769, Pf03028, Pf03193, Pf07728, Pf08385, Pf08393, Pf10174, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13401" 110350 ENSMUSG00000047193.16 Dync2h1 9 Intraflagellar transport; Hedgehog 'off' state Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 Medium Q99M74 "Keratin, type II cuticular Hb2 OS=Mus musculus OX=10090 GN=Krt82 PE=1 SV=2" 0.04 1.521 1 1 3 1 516 57.1 6.25 1 1 1 2 11607726 4983247 6520991.5 1 1 1 structural molecule activity Pf00038 114566 ENSMUSG00000049548.8 Krt82 15 Formation of the cornified envelope 0 High Q8K354 Carbonyl reductase [NADPH] 3 OS=Mus musculus OX=10090 GN=Cbr3 PE=1 SV=1 0.01 2.754 8 2 3 1 277 30.9 6.57 1 1 1 1 1 1 metabolic process cytoplasm;cytosol catalytic activity;nucleotide binding "Pf00106, Pf08659, Pf13561" 109857 ENSMUSG00000022947.7 Cbr3 16 Phase I - Functionalization of compounds Metabolic pathways; Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450 0 High Q8K310 Matrin-3 OS=Mus musculus OX=10090 GN=Matr3 PE=1 SV=1 0 6.917 4 2 3 2 846 94.6 6.25 1 2 1 2 1066673.5 932104.1875 1 1 defense response;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 17184 ENSMUSG00000037236.14 Matr3 18 0 High Q91WT8 RNA-binding protein 47 OS=Mus musculus OX=10090 GN=Rbm47 PE=1 SV=1 0 9.858 5 2 3 2 590 64 8.19 2 1 2 1 1064222.906 2097431.188 2 2 cell differentiation;metabolic process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 245945 ENSMUSG00000070780.11 Rbm47 5 0 High Q920I9 WD repeat-containing protein 7 OS=Mus musculus OX=10090 GN=Wdr7 PE=1 SV=3 0 10.442 5 3 3 3 1489 163.3 6.9 3 3 265830.4063 1632514.813 1 3 cell differentiation cytoplasm protein binding Pf00400 104082 ENSMUSG00000040560.9 Wdr7 18 0 High A0A5F8MPE3 PR domain-containing protein 11 OS=Mus musculus OX=10090 GN=Prdm11 PE=1 SV=1 0 9.793 5 3 3 3 1172 133.7 6.13 3 3 322824.625 1906667.047 1 3 0 High P62897 "Cytochrome c, somatic OS=Mus musculus OX=10090 GN=Cycs PE=1 SV=2" 0.002 4.4 10 1 3 1 105 11.6 9.58 1 1 1 1 1 1 187095.9375 569947.625 997448.1875 1 1 2 cell death;metabolic process;regulation of biological process;transport cytosol;mitochondrion;nucleus metal ion binding;protein binding "Pf00034, Pf13442, Pf14495" 13063; 672195 ENSMUSG00000058927.5; ENSMUSG00000063694.5 Cycs; Gm10053 6; 19 Activation of caspases through apoptosome-mediated cleavage; Formation of apoptosome; Transcriptional activation of mitochondrial biogenesis; Cytochrome c-mediated apoptotic response; Detoxification of Reactive Oxygen Species; Release of apoptotic factors from the mitochondria; Respiratory electron transport; Apoptotic factor-mediated response Herpes simplex infection; Platinum drug resistance; p53 signaling pathway; Amyotrophic lateral sclerosis (ALS); Toxoplasmosis; Metabolic pathways; Small cell lung cancer; Tuberculosis; Hepatitis B; Huntington's disease; Sulfur metabolism; Apoptosis - multiple species; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Legionellosis; Pathways in cancer; Influenza A; Alzheimer's disease; Viral myocarditis; Colorectal cancer; Apoptosis 0 High P43275 Histone H1.1 OS=Mus musculus OX=10090 GN=H1-1 PE=1 SV=2 0 6.699 9 2 3 1 213 21.8 10.93 2 1 2 1 504404.9688 755357.4375 1620013.875 1 1 1 cell organization and biogenesis;regulation of biological process cell surface;chromosome;nucleus DNA binding;protein binding Pf00538 80838 ENSMUSG00000049539.2 Hist1h1a 13 0 High A0A140T8T7 Collagen alpha-5(VI) chain OS=Mus musculus OX=10090 GN=Col6a5 PE=1 SV=1 0 7.159 2 3 3 3 2640 289.3 6.67 3 3 12840.92188 103691.2656 281597.875 1 1 1 extracellular "Pf00092, Pf01391, Pf05762, Pf10138, Pf13519" 665033 ENSMUSG00000091345.9 Col6a5 9 Collagen degradation 0 High Q3V117 ATP-citrate synthase OS=Mus musculus OX=10090 GN=Acly PE=1 SV=1 0 6.801 1 1 3 1 1101 120.7 7.44 1 1 1 1 1 1 400267.7813 478663 738619.0625 1 1 1 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00285, Pf00549, Pf02629, Pf08442" 104112 ENSMUSG00000020917.17 Acly 11 0 High H3BJU7 Rho guanine nucleotide exchange factor 2 OS=Mus musculus OX=10090 GN=Arhgef2 PE=1 SV=1 0 8.287 4 2 3 2 956 108.5 6.87 1 2 1 2 186039.4063 427880.1875 570451.5625 1 1 1 regulation of biological process;response to stimulus metal ion binding "Pf00130, Pf00169, Pf00621, Pf07649" ENSMUSG00000028059.15 3 0 Low P56475 Gamma-aminobutyric acid receptor subunit rho-1 OS=Mus musculus OX=10090 GN=Gabrr1 PE=2 SV=2 0.088 1.204 1 1 3 1 480 55.5 8.92 1 1 1 2 2061987.5 3936219.75 4366699.5 1 1 1 regulation of biological process;response to stimulus;transport membrane protein binding;receptor activity;signal transducer activity;transporter activity "Pf02931, Pf02932" 14408 ENSMUSG00000028280.9 Gabrr1 4 GABA A (rho) receptor activation Morphine addiction; Retrograde endocannabinoid signaling; GABAergic synapse; Nicotine addiction; Neuroactive ligand-receptor interaction 0 High O55186 CD59A glycoprotein OS=Mus musculus OX=10090 GN=Cd59a PE=2 SV=1 0.002 4.196 14 1 3 1 123 13.6 7.47 1 1 1 2 2752091 2686034 1 1 regulation of biological process extracellular;membrane protein binding Pf00021 12509 ENSMUSG00000032679.12 Cd59a 2 Regulation of Complement cascade; Cargo concentration in the ER; COPI-mediated anterograde transport; COPII (Coat Protein 2) Mediated Vesicle Transport; Neutrophil degranulation Complement and coagulation cascades; Hematopoietic cell lineage 0 High Q91WD5 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs2 PE=1 SV=1" 0 6.725 10 3 3 3 463 52.6 6.99 1 2 1 2 867481.3125 2510119.75 2708448.875 2 2 2 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00346 226646 ENSMUSG00000013593.12 Ndufs2 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q62219 Transforming growth factor beta-1-induced transcript 1 protein OS=Mus musculus OX=10090 GN=Tgfb1i1 PE=1 SV=2 0 10.093 8 2 3 2 461 50.1 6.73 1 2 1 2 3616868.906 8710537.438 6668266.75 2 2 2 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus metal ion binding;protein binding Pf00412 21804 ENSMUSG00000030782.16 Tgfb1i1 7 0 High Q8QZY9 Splicing factor 3B subunit 4 OS=Mus musculus OX=10090 GN=Sf3b4 PE=1 SV=1 0 8.448 11 3 3 3 424 44.3 8.56 1 2 1 2 99546.13281 2007382.625 2089385.875 1 3 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 107701 ENSMUSG00000068856.3 Sf3b4 3 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q8BMJ2 "Leucine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Lars1 PE=1 SV=2" 0 6.448 4 3 3 3 1178 134.1 7.05 1 2 1 2 119117.9609 1176733.125 761110.7813 1 2 2 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;vacuole catalytic activity;enzyme regulator activity;nucleotide binding "Pf00133, Pf01406, Pf08264, Pf09334" 107045 ENSMUSG00000024493.8 Lars 18 Aminoacyl-tRNA biosynthesis 0 High Q91YN9 BAG family molecular chaperone regulator 2 OS=Mus musculus OX=10090 GN=Bag2 PE=1 SV=1 0 8.062 24 3 3 3 210 23.5 6.42 2 1 2 1 1048648.594 1493014 1652849.625 2 2 2 metabolic process;regulation of biological process enzyme regulator activity;nucleotide binding;protein binding Pf02179 213539 ENSMUSG00000042215.8 Bag2 1 Protein processing in endoplasmic reticulum 0 High Q61792 LIM and SH3 domain protein 1 OS=Mus musculus OX=10090 GN=Lasp1 PE=1 SV=1 0 5.428 8 2 3 2 263 30 7.05 1 1 1 1 1 1 661706.25 2158001.188 1402685.75 1 2 1 transport cytoplasm;cytoskeleton metal ion binding;protein binding;transporter activity "Pf00018, Pf00412, Pf00880, Pf07653, Pf14604" 16796 ENSMUSG00000038366.15 Lasp1 11 0 High O08529 Calpain-2 catalytic subunit OS=Mus musculus OX=10090 GN=Capn2 PE=1 SV=4 0 5.012 3 1 3 1 700 79.8 4.96 1 1 1 2 158076.6875 334044.2188 584932.1875 1 1 1 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00648, Pf01067, Pf13833" 12334 ENSMUSG00000026509.15 Capn2 1 Degradation of the extracellular matrix Focal adhesion; Alzheimer's disease; Protein processing in endoplasmic reticulum; Apoptosis 0 High Q3TML0 Protein disulfide-isomerase A6 OS=Mus musculus OX=10090 GN=Pdia6 PE=1 SV=1 0 7.522 11 3 3 3 445 48.7 5.19 2 1 2 1 410269.2813 2070780.688 1122935.75 1 2 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane;organelle lumen catalytic activity "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 71853 ENSMUSG00000020571.12 Pdia6 12 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation Protein processing in endoplasmic reticulum 0 High Q61768 Kinesin-1 heavy chain OS=Mus musculus OX=10090 GN=Kif5b PE=1 SV=3 0 4.933 2 2 3 2 963 109.5 6.44 1 2 1 2 955227.2188 1308773.563 2 2 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf01576, Pf02463, Pf03999, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf07111, Pf07888, Pf10174, Pf12128, Pf13514, Pf14915" 16573 ENSMUSG00000006740.13 Kif5b 18 Endocytosis; Dopaminergic synapse 0 High P62267 40S ribosomal protein S23 OS=Mus musculus OX=10090 GN=Rps23 PE=1 SV=3 0 7.152 16 2 3 2 143 15.8 10.49 1 2 1 2 2148266.938 6631125.375 8914210.875 2 2 2 cell organization and biogenesis;metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00164 66475 ENSMUSG00000049517.7 Rps23 13 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 Medium A0A0G2JGN4 Small nuclear ribonucleoprotein-associated protein B OS=Mus musculus OX=10090 GN=Snrpb PE=4 SV=1 0.027 1.836 10 1 3 1 70 8.4 9.07 1 1 2 1 22651.48242 2207583.75 3619243.5 1 1 1 regulation of biological process "Pf01423, Pf03614" ENSMUSG00000027404.15 2 0 High A0A0B4J1J7 Immunoglobulin heavy variable 1-82 OS=Mus musculus OX=10090 GN=Ighv1-82 PE=1 SV=1 0 4.908 19 1 3 1 98 10.6 9.29 1 1 2 1 1698508.5 2850399.5 3512964.25 1 1 1 Pf07686 16061 ENSMUSG00000095127.2 Igh-VJ558 12 0 Medium Q9CU62 Structural maintenance of chromosomes protein 1A OS=Mus musculus OX=10090 GN=Smc1a PE=1 SV=4 0.017 2.355 1 1 3 1 1233 143.1 7.64 1 1 1 1 1 1 12895044 13261698 8782794 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus nucleotide binding;protein binding;RNA binding "Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558" 24061 ENSMUSG00000041133.11 Smc1a X Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Meiotic Synapsis; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Mus musculus biological processes; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 High Q9CPP0 Nucleoplasmin-3 OS=Mus musculus OX=10090 GN=Npm3 PE=1 SV=3 0 9.212 18 2 3 2 175 19 4.82 1 1 1 1 1 1 1048883.25 1307447.25 2309522.25 1 1 1 Met-loss+Acetyl [N-Term] metabolic process cytoskeleton;cytosol;nucleus protein binding;RNA binding Pf03066 18150 ENSMUSG00000056209.7 Npm3 19 0 Low E0CX28 Zinc finger and BTB domain-containing protein 20 (Fragment) OS=Mus musculus OX=10090 GN=Zbtb20 PE=1 SV=1 0.054 1.43 14 1 3 1 63 6.7 9.38 1 1 1 1 1 1 689577.0156 817747.25 587211.625 1 1 1 ENSMUSG00000022708.16 16 0 High O70577 Solute carrier family 22 member 2 OS=Mus musculus OX=10090 GN=Slc22a2 PE=1 SV=1 0 7.571 5 2 3 2 553 61.8 7.84 1 2 1 2 350936.9688 1978494.875 3071614.75 1 2 2 transport membrane transporter activity "Pf00083, Pf07690, Pf13347" 20518 ENSMUSG00000040966.9 Slc22a2 17 Na+/Cl- dependent neurotransmitter transporters; Norepinephrine Neurotransmitter Release Cycle; Organic cation transport; Neurotransmitter clearance; Abacavir transmembrane transport Choline metabolism in cancer 0 High E9Q8F0 RNA-binding protein 39 OS=Mus musculus OX=10090 GN=Rbm39 PE=1 SV=1 0 9.295 9 3 3 3 415 47 10.52 1 2 1 2 493131.0625 2428328 1365790.25 1 2 1 metabolic process nucleus RNA binding "Pf00076, Pf13893, Pf14259, Pf15519" ENSMUSG00000027620.16 2 0 High A0A0R4J0I1 Serine protease inhibitor A3K OS=Mus musculus OX=10090 GN=Serpina3k PE=1 SV=1 0 6.649 12 3 3 3 418 46.6 5.16 3 3 121911.2266 3066616.781 1815478.688 1 3 2 regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding Pf00079 20714 ENSMUSG00000058207.6 Serpina3k 12 Platelet degranulation ; Neutrophil degranulation 0 High Q9D7N3 "28S ribosomal protein S9, mitochondrial OS=Mus musculus OX=10090 GN=Mrps9 PE=1 SV=3" 0 7.489 7 2 3 2 390 44.9 8.81 1 1 1 1 1 1 382098.125 726772.375 650750.9375 1 1 1 metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00380 69527 ENSMUSG00000060679.14 Mrps9 1 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High P01592 Immunoglobulin J chain OS=Mus musculus OX=10090 GN=Jchain PE=1 SV=4 0.003 3.25 14 2 3 2 159 18 4.89 2 1 2 1 1917465.813 1423722.625 1581868.813 2 2 2 defense response;regulation of biological process;response to stimulus extracellular DNA binding;protein binding Pf15097 16069 ENSMUSG00000067149.6 Igj; Jchain 5 Cell surface interactions at the vascular wall; Scavenging of heme from plasma 0 High Q920A5 Retinoid-inducible serine carboxypeptidase OS=Mus musculus OX=10090 GN=Scpep1 PE=1 SV=2 0 7.254 5 2 3 2 452 50.9 5.66 2 1 2 1 470290.0781 2357289.125 1929466.875 2 2 1 metabolic process cytosol;extracellular catalytic activity Pf00450 74617 ENSMUSG00000000278.10 Scpep1 11 0 High A0A1L1SUX8 Thy-1 membrane glycoprotein (Fragment) OS=Mus musculus OX=10090 GN=Thy1 PE=1 SV=1 0 13.566 23 2 3 2 125 14 9.22 1 2 1 2 371531.1875 1755649.438 4018829.75 1 2 2 regulation of biological process protein binding Pf00047 ENSMUSG00000032011.5 9 0 High B8JK33 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus OX=10090 GN=Hnrnpm PE=1 SV=1 0 7.544 5 3 3 3 640 68.1 8.32 2 1 2 1 metabolic process;regulation of biological process cell surface;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf11532, Pf13893, Pf14259" 76936 ENSMUSG00000059208.14 Hnrnpm 17 0 High Q62433 Protein NDRG1 OS=Mus musculus OX=10090 GN=Ndrg1 PE=1 SV=1 0 7.632 14 3 3 3 394 43 6.1 1 2 1 2 469282.8125 1510608.375 2587676.375 1 1 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding "Pf00561, Pf03096, Pf12697" 17988 ENSMUSG00000005125.12 Ndrg1 15 0 High Q63918 Caveolae-associated protein 2 OS=Mus musculus OX=10090 GN=Cavin2 PE=1 SV=3 0 7.517 6 2 3 2 418 46.7 5.21 1 2 1 2 748049.2188 3001867.25 3120535.375 2 2 2 cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane protein binding Pf15237 20324 ENSMUSG00000045954.7 Sdpr; Cavin2 1 0 High Q3TCR7 Dynamin-2 OS=Mus musculus OX=10090 GN=Dnm2 PE=1 SV=1 0 5.802 6 3 3 3 869 97.9 7.44 3 3 99363.03125 380154.9375 836487.25 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00169, Pf00350, Pf01031, Pf02212" 13430 ENSMUSG00000033335.17 Dnm2 9 0 High A2AQN4 "Acetyl-coenzyme A synthetase, cytoplasmic OS=Mus musculus OX=10090 GN=Acss2 PE=1 SV=1" 0.002 4.51 3 2 3 2 714 80.3 6.95 2 3 1055767.375 710754.75 1 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding "Pf00501, Pf13193" 60525 ENSMUSG00000027605.18 Acss2 2 0 High Q9CW79 Golgin subfamily A member 1 OS=Mus musculus OX=10090 GN=Golga1 PE=1 SV=2 0 7.457 6 3 3 3 758 87.3 5.52 2 1 2 1 transport Golgi;membrane protein binding "Pf01465, Pf07888, Pf12128, Pf13166" 76899 ENSMUSG00000026754.16 Golga1 2 Retrograde transport at the Trans-Golgi-Network 0 High O70310 Glycylpeptide N-tetradecanoyltransferase 1 OS=Mus musculus OX=10090 GN=Nmt1 PE=1 SV=1 0 7.193 9 2 3 2 496 56.9 8 1 2 1 2 1176435.875 2097098.625 1 2 metabolic process cytoplasm;cytosol;membrane catalytic activity "Pf01233, Pf02799" 18107 ENSMUSG00000020936.8 Nmt1 11 "Inactivation, recovery and regulation of the phototransduction cascade; Activation, myristolyation of BID and translocation to mitochondria; Signaling by GPCR" 0 High P35230 Regenerating islet-derived protein 3-beta OS=Mus musculus OX=10090 GN=Reg3b PE=1 SV=1 0 9.745 34 3 3 3 175 19.5 7.58 3 3 107843.0234 900428.75 2523905.125 1 1 2 cell organization and biogenesis;defense response;regulation of biological process;response to stimulus cytoplasm;extracellular protein binding Pf00059 18489 ENSMUSG00000071356.7 Reg3b 6 Antimicrobial peptides 0 High Q6A0A9 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus OX=10090 GN=FAM120A PE=1 SV=2 0 4.942 3 3 3 3 1112 121.6 8.92 1 2 1 2 1141339.75 2844266.563 1 2 Met-loss [N-Term] cytoplasm;cytosol;membrane;nucleus RNA binding Pf13458 218236 ENSMUSG00000038014.7 Fam120a 13 0 Low Q8VFG4 Olfactory receptor OS=Mus musculus OX=10090 GN=Olfr1370 PE=2 SV=1 0.074 1.318 3 1 3 1 316 35.3 8.9 1 1 1 1 1 1 2692061.25 2480495.75 4363939.5 1 1 1 regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity "Pf00001, Pf13853" 258528 ENSMUSG00000042869.2 Olfr1370 13 Olfactory transduction 0 High Q61382 TNF receptor-associated factor 4 OS=Mus musculus OX=10090 GN=Traf4 PE=1 SV=2 0 6.104 3 1 3 1 470 53.5 8.15 1 1 1 1 1 1 359292.1875 519552.7813 1 1 cell death;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus metal ion binding;protein binding "Pf00097, Pf00917, Pf02176, Pf13923" 22032 ENSMUSG00000017386.10 Traf4 11 Small cell lung cancer; Pathways in cancer 0 High Q8CHT0 "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Aldh4a1 PE=1 SV=3" 0 6.937 8 3 3 3 562 61.8 8.24 2 1 2 1 593709.75 1174831.5 2758847.063 2 2 3 cell organization and biogenesis;metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00171, Pf06810" 212647 ENSMUSG00000028737.15 Aldh4a1 4 Proline catabolism; Glyoxylate metabolism and glycine degradation "Arginine and proline metabolism; Metabolic pathways; Alanine, aspartate and glutamate metabolism" 0 High Q5SUF2 Luc7-like protein 3 OS=Mus musculus OX=10090 GN=Luc7l3 PE=1 SV=1 0 10.089 9 3 3 3 432 51.4 9.77 2 1 2 1 2916806.375 2435068 3 1 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex DNA binding;RNA binding Pf03194 67684 ENSMUSG00000020863.15 Luc7l3 11 0 High Q61838 Pregnancy zone protein OS=Mus musculus OX=10090 GN=Pzp PE=1 SV=3 0 5.592 3 3 3 3 1495 165.7 6.68 1 1 1 1 1 1 1140065.563 2791207.313 1570534 2 3 2 regulation of biological process extracellular enzyme regulator activity;protein binding "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 11287 ENSMUSG00000030359.14 Pzp 6 0 High E9Q715 Putative RNA-binding protein Luc7-like 2 OS=Mus musculus OX=10090 GN=Luc7l2 PE=1 SV=1 0.003 3.657 8 2 3 2 272 32.6 10.01 2 1 2 1 239830.4688 4541653.125 2530207.25 1 2 1 cell organization and biogenesis nucleus;spliceosomal complex protein binding;RNA binding Pf03194 192196 ENSMUSG00000029823.16 Luc7l2 6 0 High B9EJ86 Oxysterol-binding protein-related protein 8 OS=Mus musculus OX=10090 GN=Osbpl8 PE=1 SV=1 0 9.86 5 3 3 3 889 101.2 6.96 1 2 1 2 365367.8438 835144.5625 982282.5 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;membrane;nucleus protein binding;transporter activity "Pf00169, Pf01237" 237542 ENSMUSG00000020189.14 Osbpl8 10 Acyl chain remodelling of PS 0 High P10810 Monocyte differentiation antigen CD14 OS=Mus musculus OX=10090 GN=Cd14 PE=1 SV=1 0 10.094 8 2 3 2 366 39.2 5.21 2 1 2 1 115788.5625 1005980.25 1 2 defense response;regulation of biological process;response to stimulus;transport cell surface;extracellular;Golgi;membrane protein binding 12475 ENSMUSG00000051439.6 Cd14 18 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Ligand-dependent caspase activation; Activated TLR4 signalling; Regulation of TLR by endogenous ligand; Neutrophil degranulation; IKK complex recruitment mediated by RIP1; Transfer of LPS from LBP carrier to CD14; TRAF6-mediated induction of TAK1 complex within TLR4 complex; TRIF-mediated programmed cell death Regulation of actin cytoskeleton; MAPK signaling pathway; Tuberculosis; Phagosome; Toll-like receptor signaling pathway; Transcriptional misregulation in cancer; Pertussis; Salmonella infection; Legionellosis; NF-kappa B signaling pathway; Hematopoietic cell lineage; Amoebiasis 0 High Q9CQE8 "RNA transcription, translation and transport factor protein OS=Mus musculus OX=10090 GN=RTRAF PE=1 SV=1" 0 8.315 9 2 3 2 244 28.1 6.89 1 2 1 2 1108243.125 2326124.906 3385091.781 1 2 2 metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus protein binding;RNA binding Pf10036 68045 ENSMUSG00000021807.5 2700060E02Rik; Rtraf 14 0 High Z4YKM2 "CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Mus musculus OX=10090 GN=Cisd3 PE=1 SV=1" 0 6.356 18 2 3 2 115 13.1 9.83 1 1 1 1 1 1 1104842.688 1988834.25 4124852.375 2 2 2 mitochondrion metal ion binding Pf09360 217149 ENSMUSG00000078695.8 Cisd3 11 0 High Q91W43 "Glycine dehydrogenase (decarboxylating), mitochondrial OS=Mus musculus OX=10090 GN=Gldc PE=1 SV=1" 0 12.422 5 3 3 3 1025 113.2 7.56 2 1 2 1 1275088.25 1 metabolic process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf01212, Pf02347" 104174 ENSMUSG00000024827.9 Gldc 19 Glycine degradation "Metabolic pathways; Glycine, serine and threonine metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High Q9CY16 "28S ribosomal protein S28, mitochondrial OS=Mus musculus OX=10090 GN=Mrps28 PE=1 SV=1" 0.006 2.955 10 2 3 2 186 20.5 8.92 2 1 2 1 166582.2656 698984.4375 1093882.375 1 2 2 mitochondrion;ribosome RNA binding Pf10246 66230 ENSMUSG00000040269.5 Mrps28 3 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q91Z96 BMP-2-inducible protein kinase OS=Mus musculus OX=10090 GN=Bmp2k PE=1 SV=1 0 11.679 4 3 3 3 1138 126.1 6.8 2 1 2 1 979696.9063 3304895.563 2281396.875 2 3 2 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf15282" 140780 ENSMUSG00000034663.13 Bmp2k 5 Transcriptional misregulation in cancer 0 High Q9CQZ6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Mus musculus OX=10090 GN=Ndufb3 PE=1 SV=1 0 5.008 17 2 3 2 104 11.7 9.04 1 2 1 2 988105 2549425.125 1132471.25 2 2 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion Pf08122 66495 ENSMUSG00000026032.8 Ndufb3 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q8JZV9 3-hydroxybutyrate dehydrogenase type 2 OS=Mus musculus OX=10090 GN=Bdh2 PE=1 SV=1 0 6.024 9 2 3 2 245 26.7 7.99 1 1 1 1 1 1 931032.6563 1958184.875 1717212.813 2 2 2 cell differentiation;metabolic process cytoplasm;cytosol catalytic activity;nucleotide binding "Pf00106, Pf13460, Pf13561" 69772 ENSMUSG00000028167.15 Bdh2 3 Synthesis of Ketone Bodies Metabolic pathways; Butanoate metabolism; Synthesis and degradation of ketone bodies 0 High P51661 Corticosteroid 11-beta-dehydrogenase isozyme 2 OS=Mus musculus OX=10090 GN=Hsd11b2 PE=1 SV=2 0 14.823 15 3 3 3 386 42.2 9.25 3 3 262487.5313 582487 1932613.188 1 1 2 metabolic process;response to stimulus cytoplasm;endoplasmic reticulum catalytic activity;nucleotide binding "Pf00106, Pf08643, Pf13561" 15484 ENSMUSG00000031891.6 Hsd11b2 8 Glucocorticoid biosynthesis Steroid hormone biosynthesis; Aldosterone-regulated sodium reabsorption 0 Medium P10078 Zinc finger protein 28 OS=Mus musculus OX=10090 GN=Zfp28 PE=2 SV=3 0.01 2.528 1 1 3 1 825 93.3 9.17 1 1 2 1 4914009.125 5301893.25 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf01352, Pf13465" 22690 ENSMUSG00000062861.8 Zfp28 7 0 High Q8QZY2 Glycerate kinase OS=Mus musculus OX=10090 GN=Glyctk PE=1 SV=1 0 8.073 7 2 3 2 523 55.3 6.67 2 1 2 1 323177.6875 1907497.188 2655217.125 1 2 2 metabolic process cytoplasm;cytosol;Golgi;mitochondrion catalytic activity;nucleotide binding "Pf05161, Pf13660" 235582 Glyctk 9 "Metabolic pathways; Glycine, serine and threonine metabolism; Pentose phosphate pathway; Carbon metabolism; Glycerolipid metabolism; Glyoxylate and dicarboxylate metabolism" 0 High A0A0R4J042 Resistin-like beta OS=Mus musculus OX=10090 GN=Retnlb PE=4 SV=1 0.004 3.011 11 1 3 1 105 11.2 7.93 1 1 1 2 3529651.5 3447187.75 4494034.5 1 1 1 regulation of biological process extracellular protein binding Pf06954 57263 ENSMUSG00000022650.6 Retnlb 16 0 High Q9DBX3 Sushi domain-containing protein 2 OS=Mus musculus OX=10090 GN=Susd2 PE=1 SV=1 0 8.948 4 2 3 2 820 90.6 6.62 1 2 1 2 226725.9844 696320.625 1903012.5 1 1 2 regulation of biological process;response to stimulus;transport membrane receptor activity "Pf00084, Pf00094, Pf01033, Pf03782, Pf05587" 71733 ENSMUSG00000006342.15 Susd2 10 0 High P01644 Ig kappa chain V-V region HP R16.7 OS=Mus musculus OX=10090 PE=1 SV=1 0 7.701 24 2 3 1 108 11.9 7.97 2 3 3013096 1136462.5 815892.1875 1 1 1 "Pf00047, Pf07679, Pf07686" 56304 Ce9 6 0 High A0A140LIZ5 26S proteasome regulatory subunit 6B OS=Mus musculus OX=10090 GN=Psmc4 PE=1 SV=1 0 14.436 8 2 3 2 387 43.5 5.26 2 1 2 1 316703.8125 1044669.688 1383068.813 2 2 2 metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00006, Pf00910, Pf01057, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191" ENSMUSG00000030603.16 7 0 High P03911 NADH-ubiquinone oxidoreductase chain 4 OS=Mus musculus OX=10090 GN=Mtnd4 PE=1 SV=1 0 12.535 4 1 3 1 459 51.8 9.38 1 1 2 1 82897.86719 1464964.25 1126585.25 1 1 1 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity "Pf00361, Pf01059" 17719; 3338899 ENSMUSG00000064363.1 ND4 MT Complex I biogenesis Metabolic pathways; Oxidative phosphorylation; Parkinson's disease 0 High Q8BU14 Translocation protein SEC62 OS=Mus musculus OX=10090 GN=Sec62 PE=1 SV=1 0 4.713 5 2 3 2 398 45.6 7.31 1 2 1 2 1052140.219 1746343.375 706950.3125 2 2 1 cell organization and biogenesis;transport endoplasmic reticulum;membrane transporter activity Pf03839 69276 ENSMUSG00000027706.8 Sec62 3 XBP1(S) activates chaperone genes Protein export; Protein processing in endoplasmic reticulum 0 High A0A1B0GT04 Glutaredoxin-3 (Fragment) OS=Mus musculus OX=10090 GN=Glrx3 PE=1 SV=1 0 7.758 15 2 3 2 163 18.1 4.78 2 1 2 1 277581.3438 609756.1875 962552.75 1 1 1 cellular homeostasis;metabolic process;regulation of biological process spliceosomal complex catalytic activity "Pf00085, Pf00462, Pf02114, Pf02966, Pf13098, Pf13905" ENSMUSG00000031068.8 7 0 High Q99MX1 Ubiquitin carboxyl-terminal hydrolase 26 OS=Mus musculus OX=10090 GN=Usp26 PE=1 SV=2 0.002 3.859 1 1 3 1 835 95.4 7.78 1 1 1 2 1076264.406 6494201.25 9989337.5 1 1 1 metabolic process nucleus catalytic activity "Pf00443, Pf13423" 83563 ENSMUSG00000055780.10 Usp26 X Ub-specific processing proteases 0 High P63168 "Dynein light chain 1, cytoplasmic OS=Mus musculus OX=10090 GN=Dynll1 PE=1 SV=1" 0 7.069 38 2 3 1 89 10.4 7.4 1 1 1 1 1 1 391482.4688 1426483.375 1394964.125 1 1 1 cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;motor activity;protein binding Pf01221 56455 ENSMUSG00000009013.5 Dynll1 5 Activation of BIM and translocation to mitochondria ; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; Macroautophagy; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; RHO GTPases Activate Formins; MHC class II antigen presentation Vasopressin-regulated water reabsorption 0 High Q78JN3 "Enoyl-CoA delta isomerase 3, peroxisomal OS=Mus musculus OX=10090 GN=Eci3 PE=1 SV=1" 0 7.217 11 3 3 3 317 35.2 9.16 1 2 1 2 241414.3359 1700104.938 2046159.375 2 2 2 metabolic process catalytic activity "Pf00378, Pf00887" 69123 ENSMUSG00000021416.11 Eci3 13 Beta-oxidation of very long chain fatty acids 0 High O08997 Copper transport protein ATOX1 OS=Mus musculus OX=10090 GN=Atox1 PE=1 SV=1 0.003 3.552 38 2 3 2 68 7.3 6.51 1 2 1 2 280376.5313 383496.7813 1 1 cellular homeostasis;response to stimulus;transport cytoplasm;cytosol metal ion binding;protein binding;transporter activity Pf00403 11927 ENSMUSG00000018585.9 Atox1 11 Ion influx/efflux at host-pathogen interface Mineral absorption 0 Medium Q8C1B7 Septin-11 OS=Mus musculus OX=10090 GN=Septin11 PE=1 SV=4 0.027 1.812 3 1 3 1 431 49.7 6.68 1 1 1 2 449486.1563 802019.0625 1189293.375 1 1 1 Met-loss+Acetyl [N-Term] cell division;cell organization and biogenesis cytoplasm;cytoskeleton nucleotide binding;protein binding Pf00735 52398 ENSMUSG00000058013.11 Sept11 5 Bacterial invasion of epithelial cells 0 High P46935 E3 ubiquitin-protein ligase NEDD4 OS=Mus musculus OX=10090 GN=Nedd4 PE=1 SV=3 0 6.787 2 2 3 2 887 102.6 5.26 1 2 1 2 272192.9375 505543.1875 2032780.625 1 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;Golgi;membrane catalytic activity;protein binding "Pf00168, Pf00397, Pf00632" 17999 ENSMUSG00000032216.14 Nedd4 9 Downregulation of ERBB4 signaling; ISG15 antiviral mechanism; Regulation of PTEN stability and activity Endocytosis; Ubiquitin mediated proteolysis; Epstein-Barr virus infection 0 High Q8VIJ6 "Splicing factor, proline- and glutamine-rich OS=Mus musculus OX=10090 GN=Sfpq PE=1 SV=1" 0.002 4.221 3 2 3 2 699 75.4 9.44 1 2 1 2 1165464.781 1479204.781 3533471.125 2 2 2 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 71514 ENSMUSG00000028820.13 Sfpq 4 PTK6 Regulates Proteins Involved in RNA Processing 0 High P10605 Cathepsin B OS=Mus musculus OX=10090 GN=Ctsb PE=1 SV=2 0.002 4.456 7 2 3 2 339 37.3 5.91 1 2 1 2 86783.92969 1541813.844 1254386.188 1 2 2 cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular;membrane;mitochondrion;vacuole catalytic activity;protein binding "Pf00112, Pf08127" 13030 ENSMUSG00000021939.7 Ctsb 14 Neutrophil degranulation; Collagen degradation; Trafficking and processing of endosomal TLR NOD-like receptor signaling pathway; Lysosome; Antigen processing and presentation; Renin secretion; Apoptosis 0 High P18528 Ig heavy chain V region 6.96 OS=Mus musculus OX=10090 PE=4 SV=1 0 10.387 31 2 3 1 98 11 7.93 1 2 1 2 670793.875 810686.3125 1891735.375 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus protein binding Pf07686 777688 Gm16971; Ighv5-4 12 0 High P97450 "ATP synthase-coupling factor 6, mitochondrial OS=Mus musculus OX=10090 GN=Atp5pf PE=1 SV=1" 0.003 3.309 9 1 3 1 108 12.5 9.36 1 1 1 1 1 1 396120.4375 974789.875 2799470 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf05511 11957 ENSMUSG00000022890.13 Atp5j 16 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q8K0U4 Heat shock 70 kDa protein 12A OS=Mus musculus OX=10090 GN=Hspa12a PE=1 SV=1 0 7.952 4 2 3 2 675 74.8 6.77 2 1 2 1 1750334.156 1300268.75 2 2 nucleotide binding Pf00012 73442 ENSMUSG00000025092.6 Hspa12a 19 0 High P62192 26S proteasome regulatory subunit 4 OS=Mus musculus OX=10090 GN=Psmc1 PE=1 SV=1 0 13.506 10 3 3 3 440 49.2 6.21 3 3 1886375 2852103.063 2 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf05673, Pf05729, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 19179 ENSMUSG00000021178.8 Psmc1 12 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection; Viral carcinogenesis 0 High Q9CXW2 "28S ribosomal protein S22, mitochondrial OS=Mus musculus OX=10090 GN=Mrps22 PE=1 SV=1" 0 6.173 9 3 3 3 359 41.2 8.56 3 3 1186312.563 2251506 3199322.813 3 3 3 mitochondrion;ribosome structural molecule activity Pf10245 64655 ENSMUSG00000032459.9 Mrps22 9 Mitochondrial translation termination; Mitochondrial translation elongation 0 High A0A075B5Q9 Immunoglobulin heavy variable 5-15 OS=Mus musculus OX=10090 GN=Ighv5-15 PE=4 SV=1 0 6.658 23 2 3 1 116 12.9 8.28 1 2 1 2 711621.4531 420736.8438 2218174.75 2 1 2 ENSMUSG00000094134.2 12 1 High P01643 Ig kappa chain V-V region MOPC 173 OS=Mus musculus OX=10090 PE=1 SV=1 0 8.194 31 2 3 1 108 11.8 9.1 2 3 1123068 683322.125 1 1 Pf07686 0 High H3BJY2 "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Asap1 PE=1 SV=1" 0.01 2.781 1 1 3 1 1144 126.9 7.43 1 1 1 2 1050971.469 19740988 27888719 1 1 1 regulation of biological process enzyme regulator activity;metal ion binding;protein binding "Pf00018, Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857, Pf14604" ENSMUSG00000022377.16 15 0 High P50172 Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Mus musculus OX=10090 GN=Hsd11b1 PE=1 SV=3 0 5.637 9 2 3 2 292 32.3 8.46 2 1 2 1 954827.125 1080337.25 1 1 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane catalytic activity;nucleotide binding "Pf00106, Pf08643, Pf08659, Pf13460, Pf13561" 15483 ENSMUSG00000016194.14 Hsd11b1 1 Glucocorticoid biosynthesis Steroid hormone biosynthesis; Metabolic pathways; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 High P05533 Lymphocyte antigen 6A-2/6E-1 OS=Mus musculus OX=10090 GN=Ly6a PE=1 SV=1 0 10.93 16 1 3 1 134 14.4 4.83 1 1 1 2 299491.9375 3701729.375 3566536.375 1 2 2 membrane protein binding Pf00021 110454 ENSMUSG00000075602.10 Ly6a 15 0 High Q8BGN3 Glycerophosphocholine cholinephosphodiesterase ENPP6 OS=Mus musculus OX=10090 GN=Enpp6 PE=1 SV=1 0 10.014 7 2 3 2 440 50.6 7.31 1 2 1 2 179201.4688 736716.3125 1 1 metabolic process extracellular;membrane catalytic activity Pf01663 320981 ENSMUSG00000038173.15 Enpp6 8 Glycerophospholipid catabolism Ether lipid metabolism 0 High P59708 Splicing factor 3B subunit 6 OS=Mus musculus OX=10090 GN=Sf3b6 PE=1 SV=1 0 6.524 21 2 3 2 125 14.6 9.38 2 1 2 1 1311240.313 1223132.688 2 2 metabolic process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 66055 ENSMUSG00000037361.8 0610009D07Rik; Sf3b14; Sf3b6 12 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9JII6 Aldo-keto reductase family 1 member A1 OS=Mus musculus OX=10090 GN=Akr1a1 PE=1 SV=3 0 6.734 7 2 3 2 325 36.6 7.39 1 2 1 2 615566.625 1169906.125 1728132.125 1 1 1 Met-loss+Acetyl [N-Term] metabolic process cytosol;membrane catalytic activity Pf00248 58810 ENSMUSG00000028692.14 Akr1a1 4 Glutathione conjugation; Catabolism of glucuronate to xylulose-5-phosphate Metabolic pathways; Glycolysis / Gluconeogenesis; Glycerolipid metabolism; Pentose and glucuronate interconversions 0 High A0A1B0GSG5 Ribonuclease inhibitor OS=Mus musculus OX=10090 GN=Rnh1 PE=1 SV=1 0 8.762 8 3 3 3 492 53.9 5.01 2 1 2 1 461992.0625 1788442.813 3190143.25 2 3 3 regulation of biological process cytoplasm;cytosol enzyme regulator activity;protein binding 107702 ENSMUSG00000038650.15 Rnh1 7 0 High Q9D279 Mitotic interactor and substrate of PLK1 OS=Mus musculus OX=10090 GN=Misp PE=1 SV=1 0 5.19 6 3 3 3 648 72.2 6.18 1 2 1 2 1009437.063 2511799 2431654.875 2 3 2 cell division cytoplasm;cytoskeleton;membrane protein binding Pf15304 78906 ENSMUSG00000035852.11 9130017N09Rik; Misp 10 0 High P51175 Protoporphyrinogen oxidase OS=Mus musculus OX=10090 GN=Ppox PE=1 SV=1 0 4.552 5 2 3 2 477 50.8 8.84 1 2 1 2 173322.2188 1010739.375 1705779.375 1 2 2 metabolic process;response to stimulus membrane;mitochondrion catalytic activity "Pf01266, Pf01593, Pf13450" 19044 ENSMUSG00000062729.11 Ppox 1 Heme biosynthesis Metabolic pathways; Porphyrin and chlorophyll metabolism 0 High A0A075B680 Immunoglobulin heavy variable 1-62-2 OS=Mus musculus OX=10090 GN=Ighv1-62-2 PE=4 SV=1 0.002 4.445 19 1 3 1 100 11.2 8.43 1 1 1 2 387533.3438 697458.375 2999278 1 1 1 "Pf00047, Pf07686" ENSMUSG00000096078.2; ENSMUSG00000096577.2 12 0 High Q9CQQ7 "ATP synthase F(0) complex subunit B1, mitochondrial OS=Mus musculus OX=10090 GN=Atp5pb PE=1 SV=1" 0 5.797 9 2 3 2 256 28.9 9.06 2 3 58849.89844 1453358.531 3232848.625 1 2 2 metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;transporter activity Pf05405 11950 ENSMUSG00000000563.17 Atp5f1 3 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Medium Q3UXJ2 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus OX=10090 GN=Tgfbi PE=1 SV=1 0.01 2.723 6 2 3 2 651 70.9 7.03 1 2 1 2 21129.16797 410518.8438 473832.5938 1 1 1 cell organization and biogenesis;cell proliferation extracellular protein binding "Pf02469, Pf07546" 21810 Tgfbi 13 0 High P84244 Histone H3.3 OS=Mus musculus OX=10090 GN=H3-3a PE=1 SV=2 0 5.553 29 2 3 2 136 15.3 11.27 1 2 1 2 1560115.172 2684428.813 5401124 2 2 1 cell differentiation;cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding "Pf00125, Pf15630" 15078; 15081 ENSMUSG00000016559.14; ENSMUSG00000060743.12 H3f3a; H3f3b 1; 11 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Oxidative Stress Induced Senescence; Meiotic Recombination; Senescence-Associated Secretory Phenotype (SASP); SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; NoRC negatively regulates rRNA expression; Meiotic Synapsis; Mus musculus biological processes; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production Transcriptional misregulation in cancer; Alcoholism; Systemic lupus erythematosus 0 High Q3TDK6 Protein rogdi homolog OS=Mus musculus OX=10090 GN=Rogdi PE=1 SV=2 0 5.267 16 3 3 3 287 32.1 8.18 2 1 2 1 951207.6875 1261256.25 2 1 cell differentiation;regulation of biological process nucleus Pf10259 66049 ENSMUSG00000022540.16 Rogdi 16 0 High Q80W22 Threonine synthase-like 2 OS=Mus musculus OX=10090 GN=Thnsl2 PE=1 SV=1 0 12.248 8 3 3 3 483 54.2 6.39 1 2 1 2 142062.3281 784185.625 2892784.406 1 1 3 metabolic process catalytic activity "Pf00291, Pf14821" 232078 ENSMUSG00000054474.15 Thnsl2 6 0 High Q3TFP0 Serine/arginine-rich-splicing factor 10 OS=Mus musculus OX=10090 GN=Srsf10 PE=1 SV=1 0 4.858 13 2 3 2 182 22.1 10.33 2 1 2 1 334429.2813 3843522.438 1148958.125 1 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 14105 ENSMUSG00000028676.17 Srsf10 4 0 High Q99KB8 "Hydroxyacylglutathione hydrolase, mitochondrial OS=Mus musculus OX=10090 GN=Hagh PE=1 SV=2" 0 5.586 12 3 3 3 309 34.1 7.75 2 1 2 1 1221934.5 1399398.5 966509.5 3 2 1 metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;metal ion binding Pf00753 14651 Hagh 17 Pyruvate metabolism 0 High Q8K3J1 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs8 PE=1 SV=1" 0.003 3.479 8 2 3 2 212 24 6.21 1 2 1 2 331705.875 683227.0625 2090137.063 1 1 2 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding "Pf00037, Pf12797, Pf12837, Pf12838, Pf13183, Pf13187, Pf13237, Pf13459, Pf13484, Pf13534, Pf14697" 225887 ENSMUSG00000059734.6 Ndufs8 19 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q99KP6 Pre-mRNA-processing factor 19 OS=Mus musculus OX=10090 GN=Prpf19 PE=1 SV=1 0 10.329 10 3 3 3 504 55.2 6.61 1 2 1 2 90786.6875 1065874.188 1521551.063 1 2 2 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex catalytic activity;metal ion binding;protein binding "Pf00400, Pf04564, Pf08606, Pf11789" 28000 ENSMUSG00000024735.13 Prpf19 19 mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex Ubiquitin mediated proteolysis; Spliceosome 0 High Q9D939 Sulfotransferase 1C2 OS=Mus musculus OX=10090 GN=Sult1c2 PE=1 SV=1 0 5.788 14 2 3 2 296 34.9 7.83 2 3 1352536.625 1501459.75 1 2 metabolic process vacuole catalytic activity Pf00685 69083 ENSMUSG00000023122.6 Sult1c2 17 Cytosolic sulfonation of small molecules 0 Medium P62855 40S ribosomal protein S26 OS=Mus musculus OX=10090 GN=Rps26 PE=1 SV=3 0.01 2.6 8 1 3 1 115 13 11 1 1 1 1 1 1 2542244.25 8890279 15020127 1 1 1 metabolic process;regulation of biological process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01283 27370; 100042812 ENSMUSG00000025362.6 Rps26; Rps26-ps1 10; 8 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q91V41 Ras-related protein Rab-14 OS=Mus musculus OX=10090 GN=Rab14 PE=1 SV=3 0 8.409 7 2 3 2 215 23.9 6.21 1 1 1 1 1 1 435301.625 1523912.875 2180810.75 1 1 1 cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;endosome;Golgi;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00009, Pf00025, Pf00071, Pf04670, Pf08477" 68365 ENSMUSG00000026878.16 Rab14 2 RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the plasma membrane; Neutrophil degranulation AMPK signaling pathway 0 High A2AKK5 Acyl-coenzyme A amino acid N-acyltransferase 1 OS=Mus musculus OX=10090 GN=Acnat1 PE=1 SV=1 0 10.965 10 3 3 3 416 46 8.73 2 1 2 1 219040.2344 2189875.063 2368640.125 1 3 2 metabolic process catalytic activity "Pf04775, Pf08840" 230161 ENSMUSG00000070985.3 Acnat1 4 0 High Q9QZE5 Coatomer subunit gamma-1 OS=Mus musculus OX=10090 GN=Copg1 PE=1 SV=1 0.002 3.944 5 2 3 2 874 97.5 5.35 1 2 1 2 618789.25 900432.875 1 1 cellular component movement;transport cytoplasm;cytosol;Golgi;membrane structural molecule activity "Pf01602, Pf08752" 54161 ENSMUSG00000030058.17 Copg; Copg1 6 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q99LC3 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Mus musculus OX=10090 GN=Ndufa10 PE=1 SV=1" 0 10.54 10 2 3 2 355 40.6 7.78 1 2 1 2 1755685.5 1 cell organization and biogenesis;metabolic process;transport mitochondrion;organelle lumen catalytic activity "Pf01712, Pf02223" 67273 ENSMUSG00000026260.12 Ndufa10 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High E9Q3L2 Phosphatidylinositol 4-kinase alpha OS=Mus musculus OX=10090 GN=Pi4ka PE=1 SV=2 0 9.119 3 3 3 3 2105 236.9 7.06 3 3 222375.6406 428033.125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;nucleotide binding;protein binding "Pf00454, Pf00613" 224020 Pi4ka 16 Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system 0 High Q9CWJ9 Bifunctional purine biosynthesis protein PURH OS=Mus musculus OX=10090 GN=Atic PE=1 SV=2 0.002 4.102 5 2 2 2 592 64.2 6.76 1 1 1 1 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;protein binding "Pf01808, Pf02142" 108147 ENSMUSG00000026192.13 Atic 1 Purine ribonucleoside monophosphate biosynthesis Metabolic pathways; Purine metabolism; Antifolate resistance; One carbon pool by folate 0 High A0A0R4J0I9 Prolow-density lipoprotein receptor-related protein 1 OS=Mus musculus OX=10090 GN=Lrp1 PE=1 SV=1 0.002 4.131 1 2 2 2 4545 504.4 5.36 2 2 183472.9297 473927.125 1821041.75 2 1 2 cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus metal ion binding;protein binding;receptor activity;RNA binding "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670" 16971 ENSMUSG00000040249.15 Lrp1 10 Signaling by GPCR; Retinoid metabolism and transport; Scavenging of heme from plasma Alzheimer's disease; Malaria 0 High Q9Z0G0 PDZ domain-containing protein GIPC1 OS=Mus musculus OX=10090 GN=Gipc1 PE=1 SV=1 0 7.778 8 2 2 2 333 36.1 5.91 2 2 273240.1875 846778.875 2198367.188 1 2 2 cell communication;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane enzyme regulator activity;protein binding Pf00595 67903 ENSMUSG00000019433.9 Gipc1 8 0 High A0A1Y7VK29 Kinesin-like protein OS=Mus musculus OX=10090 GN=Kif12 PE=1 SV=1 0 7.02 5 2 2 2 643 70.8 8.56 1 1 1 1 832919.25 2084176 1512761.219 2 2 2 cellular component movement cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf12711" 16552 Kif12 4 0 High P28654 Decorin OS=Mus musculus OX=10090 GN=Dcn PE=1 SV=1 0 5.97 6 2 2 1 354 39.8 8.68 1 1 1 1 609335.125 1504814.125 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular enzyme regulator activity;protein binding;RNA binding "Pf01462, Pf12799, Pf13306, Pf13855" 13179 ENSMUSG00000019929.16 Dcn 10 A tetrasaccharide linker sequence is required for GAG synthesis; ECM proteoglycans; CS/DS degradation; Degradation of the extracellular matrix; Dermatan sulfate biosynthesis; Chondroitin sulfate biosynthesis Proteoglycans in cancer; TGF-beta signaling pathway 0 High E9Q1W7 TBC domain-containing protein kinase-like protein OS=Mus musculus OX=10090 GN=Tbck PE=1 SV=1 0 5.238 3 2 2 2 893 100.6 6.43 2 2 642301.75 852242.625 1 1 cell growth;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf00566, Pf00581, Pf07714, Pf14531" 271981 ENSMUSG00000028030.12 Tbck 3 0 Low Q9D0K2 "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus OX=10090 GN=Oxct1 PE=1 SV=1" 0.087 1.216 2 1 2 1 520 56 8.53 1 1 1 1 304630.6875 785677.625 826402.5 1 1 1 metabolic process;regulation of biological process;response to stimulus mitochondrion;organelle lumen catalytic activity;protein binding Pf01144 67041 ENSMUSG00000022186.14 Oxct1 15 Utilization of Ketone Bodies "Valine, leucine and isoleucine degradation; Butanoate metabolism; Synthesis and degradation of ketone bodies" 0 High P10922 Histone H1.0 OS=Mus musculus OX=10090 GN=H1-0 PE=2 SV=4 0.004 3.113 10 2 2 2 194 20.8 10.9 1 1 1 1 1294890.344 2703780.875 1173018 2 2 1 cell organization and biogenesis chromosome;cytoskeleton;Golgi;nucleus DNA binding;RNA binding Pf00538 14958 ENSMUSG00000096210.1 H1f0 15 Activation of DNA fragmentation factor; Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0 High Q8JZU2 "Tricarboxylate transport protein, mitochondrial OS=Mus musculus OX=10090 GN=Slc25a1 PE=1 SV=1" 0.002 3.89 6 2 2 2 311 33.9 9.89 1 1 1 1 434705.625 1479776.438 1768161.375 1 2 1 transport membrane;mitochondrion;nucleus transporter activity Pf00153 13358 ENSMUSG00000003528.14 Slc25a1 16 Gluconeogenesis; Fatty acyl-CoA biosynthesis 0 High Q8BZ09 Mitochondrial 2-oxodicarboxylate carrier OS=Mus musculus OX=10090 GN=Slc25a21 PE=1 SV=1 0 4.795 8 2 2 2 298 33.2 9.72 1 1 1 1 221443.4219 1197592.5 1010706.703 1 2 2 Met-loss+Acetyl [N-Term] transport membrane;mitochondrion transporter activity Pf00153 217593 ENSMUSG00000035472.14 Slc25a21 12 Lysine catabolism 0 High Q922Q8 Leucine-rich repeat-containing protein 59 OS=Mus musculus OX=10090 GN=Lrrc59 PE=1 SV=1 0.004 3.121 3 1 2 1 307 34.9 9.52 1 1 1 1 376294.5625 531432.9375 951141.1875 1 1 1 endoplasmic reticulum;membrane;nucleus protein binding;RNA binding "Pf12799, Pf13855" 98238 ENSMUSG00000020869.8 Lrrc59 11 0 High Q61733 "28S ribosomal protein S31, mitochondrial OS=Mus musculus OX=10090 GN=Mrps31 PE=1 SV=1" 0 5.476 9 2 2 2 384 43.9 8.51 2 2 229564.0781 535302 1 1 mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf15433 57312 ENSMUSG00000031533.4 Mrps31 8 Mitochondrial translation termination; Mitochondrial translation elongation 0 High E9QNN1 ATP-dependent RNA helicase A OS=Mus musculus OX=10090 GN=Dhx9 PE=1 SV=1 0 5.141 1 1 2 1 1384 149.6 6.83 1 1 1 1 144342.7969 554662.6875 697650 1 1 1 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus;ribosome catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717" 13211 ENSMUSG00000042699.11 Dhx9 1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activated TLR4 signalling; mRNA Splicing - Major Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; TRAF6 mediated NF-kB activation; Interleukin-1 family signaling 0 High Q3U1J4 DNA damage-binding protein 1 OS=Mus musculus OX=10090 GN=Ddb1 PE=1 SV=2 0 5.134 4 2 2 2 1140 126.8 5.26 2 2 1658777.75 1141393.75 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding "Pf03178, Pf10433" 13194 ENSMUSG00000024740.9 Ddb1 19 Dual incision in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Hepatitis B; Nucleotide excision repair; Viral carcinogenesis 0 High O09159 Lysosomal alpha-mannosidase OS=Mus musculus OX=10090 GN=Man2b1 PE=1 SV=4 0 8.101 4 2 2 2 1013 114.6 8.13 1 1 1 1 928651.9375 1382004.75 1 1 metabolic process;response to stimulus vacuole catalytic activity;metal ion binding "Pf01074, Pf07748, Pf09261" 17159 ENSMUSG00000005142.10 Man2b1 8 Lysosomal oligosaccharide catabolism; Neutrophil degranulation Lysosome; Other glycan degradation 0 High E9QPX1 Collagen alpha-1(XVIII) chain OS=Mus musculus OX=10090 GN=Col18a1 PE=1 SV=1 0 7.433 2 2 2 2 1774 182.2 5.71 1 1 1 1 194389.6563 261172.4375 313078.125 1 1 1 cell organization and biogenesis;regulation of biological process extracellular metal ion binding;protein binding;structural molecule activity "Pf01391, Pf01392, Pf06121, Pf06482, Pf13385" 12822 ENSMUSG00000001435.15 Col18a1 10 0 High P62307 Small nuclear ribonucleoprotein F OS=Mus musculus OX=10090 GN=Snrpf PE=1 SV=1 0 5.688 24 2 2 2 86 9.7 4.67 2 2 2609224.5 1714941.25 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex RNA binding Pf01423 69878 ENSMUSG00000020018.6 Snrpf 10 mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; mRNA Splicing - Major Pathway; snRNP Assembly; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs Spliceosome 0 Low P57096 Prostate stem cell antigen OS=Mus musculus OX=10090 GN=Psca PE=1 SV=2 0.054 1.42 8 1 2 1 123 13.5 7.77 1 1 1 1 365044.2188 432392.8438 1 1 regulation of biological process membrane protein binding Pf00021 72373 ENSMUSG00000022598.6 Psca 15 Post-translational modification: synthesis of GPI-anchored proteins 0 High O54749 Cytochrome P450 2J5 OS=Mus musculus OX=10090 GN=Cyp2j5 PE=1 SV=1 0.002 4.123 5 2 2 2 501 57.7 8.73 2 2 1099282.5 1986612.563 2 2 metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf00067 13109 ENSMUSG00000052520.7 Cyp2j5 4 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET); Fatty acids Ovarian steroidogenesis; Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism; Serotonergic synapse; Inflammatory mediator regulation of TRP channels 0 High O08917 Flotillin-1 OS=Mus musculus OX=10090 GN=Flot1 PE=1 SV=1 0 7.87 7 2 2 2 428 47.5 7.15 2 2 300625.6563 827579.75 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoskeleton;endosome;membrane protein binding Pf01145 14251 ENSMUSG00000059714.13 Flot1 17 Insulin signaling pathway 0 High Q8K0P3 MTOR-associated protein MEAK7 OS=Mus musculus OX=10090 GN=Meak7 PE=2 SV=1 0 4.631 3 1 2 1 455 50.8 6.52 1 1 1 1 741470.875 314856.625 1 1 regulation of biological process cytoplasm;membrane Pf07534 74347 ENSMUSG00000034105.9 4632415K11Rik; Tldc1 8 0 High P54869 "Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus musculus OX=10090 GN=Hmgcs2 PE=1 SV=2" 0.002 4.281 4 2 2 2 508 56.8 8.41 1 1 1 1 2536176.375 2650196.313 2 2 metabolic process membrane;mitochondrion;organelle lumen catalytic activity "Pf01154, Pf08540, Pf08545" 15360 ENSMUSG00000027875.12 Hmgcs2 3 Synthesis of Ketone Bodies "PPAR signaling pathway; Valine, leucine and isoleucine degradation; Metabolic pathways; Terpenoid backbone biosynthesis; Butanoate metabolism; Synthesis and degradation of ketone bodies" 0 Medium Q8JZZ0 UDP-glucuronosyltransferase 3A2 OS=Mus musculus OX=10090 GN=Ugt3a2 PE=1 SV=2 0.018 2.334 4 2 2 2 523 59.6 7.53 2 2 496018.7188 1163968.375 1 1 metabolic process;response to stimulus membrane catalytic activity "Pf00201, Pf04101" 223337 ENSMUSG00000049152.11 Ugt3a2 15 0 High Q8R0Y8 Mitochondrial coenzyme A transporter SLC25A42 OS=Mus musculus OX=10090 GN=Slc25a42 PE=1 SV=1 0 8.901 8 2 2 2 318 35.2 10.05 2 2 67782.42188 313312.1875 514043.2813 1 1 1 transport membrane;mitochondrion;nucleus catalytic activity;transporter activity Pf00153 73095 ENSMUSG00000002346.16 Slc25a42 8 0 High Q3TXS7 26S proteasome non-ATPase regulatory subunit 1 OS=Mus musculus OX=10090 GN=Psmd1 PE=1 SV=1 0.002 4.156 3 2 2 2 953 105.7 5.39 2 2 222142.7188 492002.7813 1 1 metabolic process;regulation of biological process membrane;nucleus;proteasome catalytic activity;enzyme regulator activity;protein binding "Pf01851, Pf13513, Pf13646" 70247 ENSMUSG00000026229.17 Psmd1 1 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High P01887 Beta-2-microglobulin OS=Mus musculus OX=10090 GN=B2m PE=1 SV=2 0.003 3.2 8 1 2 1 119 13.8 8.44 1 1 1 1 791759.0625 1679164.375 1 1 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;Golgi;membrane protein binding Pf07654 12010 ENSMUSG00000060802.8 B2m 2 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 signaling" Antigen processing and presentation 0 High P97393 Rho GTPase-activating protein 5 OS=Mus musculus OX=10090 GN=Arhgap5 PE=1 SV=2 0 4.655 2 2 2 2 1501 172 6.34 1 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00071, Pf00620, Pf01846" 11855 Arhgap5 12 0 High Q91WV7 Neutral and basic amino acid transport protein rBAT OS=Mus musculus OX=10090 GN=Slc3a1 PE=1 SV=1 0 5.246 4 2 2 2 685 78.1 5.66 2 2 95248.71094 837780.125 2399656.313 1 1 2 metabolic process;transport membrane catalytic activity;protein binding Pf00128 20532 ENSMUSG00000024131.7 Slc3a1 17 Amino acid transport across the plasma membrane Protein digestion and absorption 0 High F6T4M4 Serine/arginine repetitive matrix protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Srrm1 PE=1 SV=1 0 5.525 15 2 2 1 140 16.2 5.38 1 1 1 1 24815588 23088354 24510770 1 1 1 metabolic process Pf01480 ENSMUSG00000028809.16 4 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript 0 Medium Q9DCT8 Cysteine-rich protein 2 OS=Mus musculus OX=10090 GN=Crip2 PE=1 SV=1 0.01 2.478 6 2 2 2 208 22.7 8.63 1 1 1 1 179757.7813 5834416 6414194.5 1 1 1 regulation of biological process metal ion binding;protein binding Pf00412 68337 ENSMUSG00000006356.10 Crip2 12 0 High P01865 "Ig gamma-2A chain C region, membrane-bound form OS=Mus musculus OX=10090 GN=Igh-1a PE=1 SV=3" 0 6.618 7 2 2 1 398 43.9 6.29 1 1 1 1 662915.1875 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endosome;membrane protein binding Pf07654 380793; 380794 Ighg2a; Ighg 12 0 High P35487 "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha2 PE=1 SV=1" 0.004 3.022 3 1 2 1 391 43.4 8.5 1 1 1 1 1526094.75 2521409 3128392 1 1 1 metabolic process mitochondrion;organelle lumen catalytic activity Pf00676 18598 ENSMUSG00000047674.2 Pdha2 3 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 0 High A0A087WRX8 Serine/arginine repetitive matrix protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Srrm2 PE=1 SV=1 0 4.77 19 2 2 1 171 19.7 6.38 1 1 1 1 ENSMUSG00000039218.16 17 0 Low A0A2Y9CZI3 Ras-related protein Rab-44 OS=Mus musculus OX=10090 GN=Rab44 PE=1 SV=1 0.085 1.265 2 1 2 1 725 78.2 4.83 1 1 1 1 691357.1875 1145352.875 2838572.5 1 1 1 Met-loss [N-Term] 0 High Q3TIX9 U4/U6.U5 tri-snRNP-associated protein 2 OS=Mus musculus OX=10090 GN=Usp39 PE=1 SV=2 0 4.826 9 2 2 2 564 65.1 8.9 1 1 1 1 cell division;cell organization and biogenesis;metabolic process nucleus;spliceosomal complex catalytic activity;metal ion binding "Pf00443, Pf02148" 28035 ENSMUSG00000056305.4; ENSMUSG00000104250.2 Usp39 6; CHR_MG184_PATCH mRNA Splicing - Major Pathway Spliceosome 0 Medium P17665 "Cytochrome c oxidase subunit 7C, mitochondrial OS=Mus musculus OX=10090 GN=Cox7c PE=1 SV=1" 0.017 2.32 14 1 2 1 63 7.3 11 1 2 2303705 5157846 1954907.625 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02935 12867; 654359; 102642884 ENSMUSG00000017778.14 Cox7c; Gm12338; LOC100048613; LOC102642884 13; 11; 2 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 Low Q91WS7 DEP domain-containing protein 7 OS=Mus musculus OX=10090 GN=Depdc7 PE=2 SV=1 0.054 1.419 4 1 2 1 511 58.4 7.61 1 2 12181612 14790746 21820596 1 1 1 regulation of biological process;response to stimulus Pf00610 211896 ENSMUSG00000027173.7 Depdc7 2 Rho GTPase cycle 0 High Q61102 "ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus OX=10090 GN=Abcb7 PE=1 SV=3" 0 5.308 2 1 2 1 752 82.5 9.32 1 1 1 1 717901 726444.0625 1 1 cellular homeostasis;transport membrane;mitochondrion catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf00664, Pf13207, Pf13304" 11306 ENSMUSG00000031333.7 Abcb7 X Mitochondrial ABC transporters ABC transporters 0 Medium Q9CPZ8 COX assembly mitochondrial protein homolog OS=Mus musculus OX=10090 GN=Cmc1 PE=1 SV=1 0.027 1.834 10 1 2 1 106 12.5 8.24 1 1 1 1 243788.8281 614033.8125 617425.5625 1 1 1 Met-loss+Acetyl [N-Term] mitochondrion metal ion binding Pf08583 67899 ENSMUSG00000039163.10 Cmc1 9 0 High Q3TJ91 LLGL scribble cell polarity complex component 2 OS=Mus musculus OX=10090 GN=Llgl2 PE=1 SV=2 0 4.843 2 2 2 2 1027 114.3 7.46 2 2 253852.2031 1170376.438 1 2 cell division;regulation of biological process;transport cytoplasm;cytosol;membrane enzyme regulator activity;protein binding Pf08366 217325 ENSMUSG00000020782.18 Llgl2 11 Hippo signaling pathway; Tight junction 0 High P12025 Midkine OS=Mus musculus OX=10090 GN=Mdk PE=1 SV=2 0.003 3.657 14 2 2 2 140 15.4 9.7 1 1 1 1 573114.6875 1856188.063 1 2 cell differentiation;cellular component movement;defense response;development;regulation of biological process;response to stimulus cytoplasm;extracellular protein binding "Pf01091, Pf05196" 17242 ENSMUSG00000027239.14 Mdk 2 NOTCH2 Activation and Transmission of Signal to the Nucleus 0 High Q8R1Q8 Cytoplasmic dynein 1 light intermediate chain 1 OS=Mus musculus OX=10090 GN=Dync1li1 PE=1 SV=1 0.002 3.884 2 1 2 1 523 56.6 6.42 1 1 1 1 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;endosome;membrane;vacuole catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00005, Pf05783, Pf10662" 235661 ENSMUSG00000032435.9 Dync1li1 9 COPI-mediated anterograde transport; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; COPI-independent Golgi-to-ER retrograde traffic; RHO GTPases Activate Formins; MHC class II antigen presentation Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High Q9JIK9 "28S ribosomal protein S34, mitochondrial OS=Mus musculus OX=10090 GN=Mrps34 PE=1 SV=1" 0 5.979 16 2 2 2 218 25.8 10.43 2 2 2685797.625 2638179 4621784 2 2 2 cell organization and biogenesis;metabolic process mitochondrion;ribosome structural molecule activity 79044 ENSMUSG00000038880.13 Mrps34 17 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q9D3D9 "ATP synthase subunit delta, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1d PE=1 SV=1" 0 7.445 29 2 2 2 168 17.6 5.08 2 2 3036640 1 metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf02823 66043 ENSMUSG00000003072.15 Atp5d 10 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Low Q3UNH4 G protein-regulated inducer of neurite outgrowth 1 OS=Mus musculus OX=10090 GN=Gprin1 PE=1 SV=2 0.085 1.254 1 1 2 1 932 95.4 7.93 1 1 1 1 532075.8125 1653649.25 2299854.25 1 1 1 cell organization and biogenesis membrane protein binding Pf15235 26913 ENSMUSG00000069227.4 Gprin1 13 0 High Q8BIJ6 "Isoleucine--tRNA ligase, mitochondrial OS=Mus musculus OX=10090 GN=Iars2 PE=1 SV=1" 0 10.046 3 2 2 2 1012 112.7 6.81 1 1 1 1 79627.57813 1170107.438 980596.5781 1 2 2 metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;RNA binding "Pf00133, Pf01921, Pf06827, Pf08264, Pf09334, Pf13603" 381314 ENSMUSG00000026618.11 Iars2 1 Aminoacyl-tRNA biosynthesis 0 Medium Q9CYL5 Golgi-associated plant pathogenesis-related protein 1 OS=Mus musculus OX=10090 GN=Glipr2 PE=1 SV=3 0.032 1.645 8 1 2 1 154 17.1 9.51 1 1 1 1 930871.9375 718263.5 847757.375 1 1 1 regulation of biological process extracellular;Golgi;membrane protein binding Pf00188 384009 ENSMUSG00000028480.14 Glipr2 4 0 Low M0QWN7 Ubiquitin-specific peptidase 35 OS=Mus musculus OX=10090 GN=Usp35 PE=1 SV=1 0.088 1.221 3 1 2 1 1009 112.4 6.16 1 1 1 1 39233784 45462408 29136954 1 1 1 metabolic process catalytic activity "Pf00443, Pf13423" 244144 ENSMUSG00000035713.15 Usp35 7 0 Medium Q811G0 Protein PTHB1 OS=Mus musculus OX=10090 GN=Bbs9 PE=1 SV=2 0.018 2.338 3 1 2 1 885 99 6.13 1 1 1 1 cell differentiation;cell organization and biogenesis;transport cytoplasm;cytoskeleton;membrane protein binding "Pf14727, Pf14728" 319845 ENSMUSG00000035919.16 Bbs9 9 BBSome-mediated cargo-targeting to cilium 0 High Q9EPC1 Alpha-parvin OS=Mus musculus OX=10090 GN=Parva PE=1 SV=1 0 4.608 6 2 2 2 372 42.3 5.95 2 2 471751.0625 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding Pf00307 57342 ENSMUSG00000030770.15 Parva 7 Focal adhesion 0 High Q9D7S7 60S ribosomal protein L22-like 1 OS=Mus musculus OX=10090 GN=Rpl22l1 PE=1 SV=1 0 8.288 30 2 2 2 122 14.5 9.45 1 1 1 1 662474.1875 1 metabolic process ribosome RNA binding;structural molecule activity Pf01776 68028 ENSMUSG00000039221.10 Rpl22l1 3 Ribosome 0 Medium Q5DU56 Protein NLRC3 OS=Mus musculus OX=10090 GN=Nlrc3 PE=1 SV=2 0.023 1.944 1 1 2 1 1064 115.9 7.94 1 2 871061.5 1793296.25 1 1 regulation of biological process;response to stimulus cytoplasm;cytosol nucleotide binding;protein binding Pf05729 268857 Nlrc3 16 0 Medium A0A1B0GS14 Mitochondrial ribosome-associated GTPase 1 (Fragment) OS=Mus musculus OX=10090 GN=Mtg1 PE=1 SV=1 0.01 2.585 23 1 2 1 52 6.2 9.38 1 1 1 1 102395.1875 420470.6563 621061.125 1 1 1 ENSMUSG00000039018.15 7 0 Medium P62274 40S ribosomal protein S29 OS=Mus musculus OX=10090 GN=Rps29 PE=1 SV=2 0.028 1.686 13 1 2 1 56 6.7 10.13 1 1 1 1 513324.4063 1877260.875 2387447.75 1 1 1 metabolic process;regulation of biological process ribosome metal ion binding;structural molecule activity Pf00253 20090 ENSMUSG00000034892.8 Rps29 12 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High B1AZ46 Brain-specific angiogenesis inhibitor 1-associated protein 2 OS=Mus musculus OX=10090 GN=Baiap2 PE=1 SV=1 0 6.004 5 2 2 2 521 57.6 8.79 2 2 1126695.25 5603291 20481070 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane protein binding "Pf00018, Pf07653, Pf08397, Pf14604" 108100 ENSMUSG00000025372.16 Baiap2 11 0 Medium Q99LU0 Charged multivesicular body protein 1b-1 OS=Mus musculus OX=10090 GN=Chmp1b1 PE=1 SV=1 0.018 2.249 4 1 2 1 199 22.1 8.1 1 1 1 1 1415818 2019408.625 1 1 cell division;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane;nucleus protein binding Pf03357 67064 ENSMUSG00000109901.1 Chmp1b 18 Endocytosis 0 Medium P08122 Collagen alpha-2(IV) chain OS=Mus musculus OX=10090 GN=Col4a2 PE=1 SV=4 0.023 1.941 1 1 2 1 1707 167.2 8.48 1 1 1 1 852702.4375 728212.1875 1501266.875 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus extracellular structural molecule activity "Pf01391, Pf01413" 12827 ENSMUSG00000031503.13 Col4a2 8 Anchoring fibril formation; Laminin interactions; Crosslinking of collagen fibrils; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Non-integrin membrane-ECM interactions; Signaling by PDGF AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q9QZD9 Eukaryotic translation initiation factor 3 subunit I OS=Mus musculus OX=10090 GN=Eif3i PE=1 SV=1 0 6.316 8 2 2 2 325 36.4 5.64 2 2 189409.4688 679646.5 1 1 metabolic process cytoplasm protein binding;RNA binding Pf00400 54709 ENSMUSG00000028798.16 Eif3i 4 "Formation of a pool of free 40S subunits; L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit" RNA transport 0 High Q9DCH4 Eukaryotic translation initiation factor 3 subunit F OS=Mus musculus OX=10090 GN=Eif3f PE=1 SV=2 0 7.296 8 2 2 2 361 38 5.58 1 1 1 1 465670.1875 476057.5 1 1 metabolic process cytoplasm;membrane catalytic activity;protein binding;RNA binding "Pf01398, Pf13012" 66085 ENSMUSG00000031029.6 Eif3f 7 "Formation of a pool of free 40S subunits; L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit" RNA transport 0 High Q60634 Flotillin-2 OS=Mus musculus OX=10090 GN=Flot2 PE=1 SV=2 0 7.383 8 2 2 2 428 47 5.2 2 2 1727075.813 692567.5 2 1 cell organization and biogenesis;regulation of biological process cytoskeleton;endosome;membrane protein binding Pf01145 14252 ENSMUSG00000061981.14 Flot2 11 Synaptic adhesion-like molecules Insulin signaling pathway 0 Medium A0A3B2WC92 Spastin OS=Mus musculus OX=10090 GN=Spast PE=1 SV=1 0.041 1.505 3 1 2 1 581 62.7 9.76 1 1 1 1 2990438 2194555.75 1 1 0 Medium Q9DBP0 Sodium-dependent phosphate transport protein 2B OS=Mus musculus OX=10090 GN=Slc34a2 PE=1 SV=1 0.048 1.449 1 1 2 1 697 76.2 7.68 1 1 1 1 238260.9375 239681.1094 1 1 cellular homeostasis;response to stimulus;transport cytoplasm;membrane metal ion binding;protein binding;transporter activity Pf02690 20531 ENSMUSG00000029188.14 Slc34a2 5 Type II Na+/Pi cotransporters; Surfactant metabolism Mineral absorption 0 Low K4DI71 GON-4-like protein OS=Mus musculus OX=10090 GN=Gon4l PE=1 SV=1 0.062 1.371 1 1 2 1 2243 246.7 4.86 1 1 1 1 394639.5313 1124413.375 5344549.125 1 1 1 cell differentiation;regulation of biological process nucleus DNA binding Pf02671 ENSMUSG00000054199.17 3 0 Medium Q6VSS7 Reproductive homeobox 8 OS=Mus musculus OX=10090 GN=Rhox8 PE=1 SV=1 0.04 1.534 3 1 2 1 320 35.9 3.94 1 1 1 1 699507.75 942796.875 615565.875 1 1 1 nucleus DNA binding Pf00046 434768 ENSMUSG00000064137.6; ENSMUSG00000097126.3 Rhox8 X; CHR_MG4214_PATCH 0 High D3Z6I4 Quinone oxidoreductase-like protein 1 OS=Mus musculus OX=10090 GN=Cryzl1 PE=1 SV=1 0.003 3.442 7 2 2 2 333 37 6.09 2 2 157143.625 1126385.875 777954.625 1 2 1 metabolic process cytosol catalytic activity Pf00107 66609 ENSMUSG00000058240.13 Cryzl1 16 0 Low Q9JIY7 N-acetyltransferase 8 OS=Mus musculus OX=10090 GN=Nat8 PE=1 SV=1 0.097 1.119 3 1 2 1 227 25.6 9.6 1 1 1 1 376522.5938 1354777.5 2227105.25 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;Golgi;membrane catalytic activity "Pf00583, Pf13508, Pf13527, Pf13673, Pf14542" 68396 ENSMUSG00000030004.6 Nat8 6 Glutathione metabolism 0 High A0A1D5RM23 Cleavage and polyadenylation specificity factor subunit 5 OS=Mus musculus OX=10090 GN=Nudt21 PE=1 SV=1 0 6.978 8 1 2 1 218 25.2 9.36 1 1 1 1 10241539.09 5392393.688 5771315.125 2 2 2 metabolic process catalytic activity;RNA binding Pf13869 ENSMUSG00000031754.10 8 0 Low A2AAA9 C-type mannose receptor 2 OS=Mus musculus OX=10090 GN=Mrc2 PE=1 SV=1 0.097 1.123 1 1 2 1 1053 120.2 6.15 1 1 1 1 2092144.125 4207162 1 1 cell differentiation;metabolic process;transport cell surface;membrane protein binding;receptor activity;signal transducer activity "Pf00040, Pf00059" 17534 ENSMUSG00000020695.14 Mrc2 11 0 Low A0A1L1SUY8 Vacuolar protein sorting-associated protein 13C OS=Mus musculus OX=10090 GN=Vps13c PE=1 SV=1 0.082 1.287 1 1 2 1 771 88.2 8.43 1 1 1 1 1155950.375 1303058.875 1731249.625 1 1 1 cell organization and biogenesis cytosol;membrane;mitochondrion Pf12624 320528 ENSMUSG00000035284.10 Vps13c 9 0 High Q9D8N0 Elongation factor 1-gamma OS=Mus musculus OX=10090 GN=Eef1g PE=1 SV=3 0 4.854 6 2 2 2 437 50 6.74 1 1 1 1 695769.0625 1337540.938 1865407.563 2 2 2 metabolic process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497" 67160 ENSMUSG00000071644.10 Eef1g 19 Eukaryotic Translation Elongation Legionellosis 0 Low G5E8R4 Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Mus musculus OX=10090 GN=Ppp6r3 PE=1 SV=1 0.094 1.147 1 1 2 1 873 97.8 4.58 1 1 1 1 702592.875 2882224 3576383 1 1 1 regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding Pf04499 52036 ENSMUSG00000024908.14 Ppp6r3 19 0 High Q1EG27 Myosin-IIIb OS=Mus musculus OX=10090 GN=Myo3b PE=1 SV=2 0.003 3.174 1 1 2 1 1305 148 7.55 1 2 963036.375 2662665.25 5962971 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00069, Pf07714" 329421 ENSMUSG00000042064.13 Myo3b 2 0 High P25911 Tyrosine-protein kinase Lyn OS=Mus musculus OX=10090 GN=Lyn PE=1 SV=4 0.003 3.617 4 2 2 2 512 58.8 7.15 2 2 509976.4063 244639.625 1196588.938 1 1 2 cell communication;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane;nucleus;vacuole catalytic activity;nucleotide binding;protein binding "Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604" 17096 ENSMUSG00000042228.14 Lyn 4 Cell surface interactions at the vascular wall; FCERI mediated NF-kB activation; Role of LAT2/NTAL/LAB on calcium mobilization; CD28 co-stimulation; CTLA4 inhibitory signaling; FCGR activation; Cyclin D associated events in G1; CD209 (DC-SIGN) signaling; Platelet Adhesion to exposed collagen; FCERI mediated Ca+2 mobilization; GPVI-mediated activation cascade; Regulation of KIT signaling; EPHB-mediated forward signaling; FCERI mediated MAPK activation; EPHA-mediated growth cone collapse; CD22 mediated BCR regulation; Growth hormone receptor signaling; EPH-ephrin mediated repulsion of cells Epstein-Barr virus infection; Chemokine signaling pathway; Platelet activation; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Long-term depression; NF-kappa B signaling pathway; Fc epsilon RI signaling pathway; Viral carcinogenesis 0 High O35226 26S proteasome non-ATPase regulatory subunit 4 OS=Mus musculus OX=10090 GN=Psmd4 PE=1 SV=1 0 4.631 9 2 2 2 376 40.7 4.79 1 1 1 1 235030.9375 510656.1563 613688.75 1 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;proteasome protein binding;RNA binding "Pf02809, Pf04056, Pf13519" 19185 ENSMUSG00000005625.15 Psmd4 3 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High P49698 Hepatocyte nuclear factor 4-alpha OS=Mus musculus OX=10090 GN=Hnf4a PE=1 SV=2 0 7.85 7 2 2 2 474 52.7 7.42 1 1 1 1 cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00104, Pf00105" 15378 ENSMUSG00000017950.16 Hnf4a 2 Nuclear Receptor transcription pathway Maturity onset diabetes of the young; AMPK signaling pathway 0 High E9Q1X8 Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Mus musculus OX=10090 GN=Cacna2d1 PE=1 SV=2 0 6.658 2 2 2 2 1091 123.1 5.17 1 1 1 1 151408.7813 1199153.625 1504003.063 1 2 2 "Pf00092, Pf02743, Pf08399, Pf08473, Pf13519, Pf13768" ENSMUSG00000040118.15 5 0 High Q60649 Caseinolytic peptidase B protein homolog OS=Mus musculus OX=10090 GN=Clpb PE=1 SV=1 0 5.142 4 2 2 2 677 76 8.51 2 2 145754.75 255331.7813 554083.1875 1 1 1 response to stimulus mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00023, Pf06309, Pf06414, Pf07724, Pf07728, Pf10431, Pf12796, Pf13401, Pf13606, Pf13637, Pf13857" 20480 ENSMUSG00000001829.17 Clpb 7 Longevity regulating pathway - multiple species 0 High P52503 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs6 PE=1 SV=2" 0 6.097 22 2 2 2 116 13 8.65 1 1 1 1 1481476.125 1862621.188 2045390 2 2 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion Pf10276 407785 ENSMUSG00000021606.7 Ndufs6 13 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High E9PUV9 Caspase recruitment domain-containing protein 10 OS=Mus musculus OX=10090 GN=Card10 PE=1 SV=1 0 4.672 4 2 2 2 1070 119.1 6.27 1 1 1 1 1602530.125 1 metabolic process;regulation of biological process protein binding "Pf00619, Pf04111" 105844 ENSMUSG00000033170.14 Card10 15 NF-kappa B signaling pathway 0 High Q6PKB0 Fcgrt protein OS=Mus musculus OX=10090 GN=Fcgrt PE=1 SV=1 0 4.985 10 2 2 2 369 40.5 5.54 2 2 529078.3125 1941507.563 1 2 membrane protein binding;receptor activity;signal transducer activity "Pf00129, Pf07654" 14132 ENSMUSG00000003420.8 Fcgrt 7 0 High A0A087WPH7 26S proteasome regulatory subunit 6A (Fragment) OS=Mus musculus OX=10090 GN=Psmc3 PE=1 SV=6 0 6.219 10 2 2 2 305 34 4.98 1 1 1 1 425305.6563 527662.4375 1 1 metabolic process;regulation of biological process;response to stimulus catalytic activity;nucleotide binding "Pf00004, Pf01078, Pf01695, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191" ENSMUSG00000002102.15 2 0 Medium Q8BT60 Copine-3 OS=Mus musculus OX=10090 GN=Cpne3 PE=1 SV=2 0.01 2.698 5 2 2 2 533 59.5 5.78 2 2 337928.5 347394.7813 662755.8125 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding "Pf00168, Pf07002, Pf10138" 70568 ENSMUSG00000028228.5 Cpne3 4 Neutrophil degranulation; Glycerophospholipid biosynthesis 0 Low A1IGU4 Rho guanine nucleotide exchange factor 37 OS=Mus musculus OX=10090 GN=Arhgef37 PE=2 SV=1 0.069 1.359 2 1 2 1 676 76.5 5.9 1 1 1 1 421252.1875 1 regulation of biological process;response to stimulus cytoplasm protein binding "Pf00018, Pf00621, Pf03114, Pf07653, Pf08239, Pf14604" 328967 Arhgef37 18 0 High Q91VT4 Carbonyl reductase family member 4 OS=Mus musculus OX=10090 GN=Cbr4 PE=1 SV=2 0 7.973 13 2 2 2 236 25.4 9.69 2 2 207788.9219 2050077.5 3093397.25 1 2 2 cell organization and biogenesis;metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00106, Pf03435, Pf08659, Pf13561" 234309 ENSMUSG00000031641.14 Cbr4 8 Fatty acyl-CoA biosynthesis 0 High Q8BWM0 Prostaglandin E synthase 2 OS=Mus musculus OX=10090 GN=Ptges2 PE=1 SV=3 0 7.814 5 2 2 2 384 43.3 9 1 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;mitochondrion;nucleus catalytic activity;DNA binding;protein binding "Pf00462, Pf13409, Pf13417, Pf14497" 96979 ENSMUSG00000026820.5 Ptges2 2 Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Metabolic pathways; Arachidonic acid metabolism 0 High A0A0G2JEQ3 Syntaxin-binding protein 3 OS=Mus musculus OX=10090 GN=Stxbp3 PE=1 SV=1 0.002 3.827 12 1 2 1 146 17 8.56 1 1 1 1 146332.2813 241884.2656 1 1 response to stimulus;transport cytosol;membrane protein binding Pf00995 ENSMUSG00000027882.18 3 0 Medium Q71LX4 Talin-2 OS=Mus musculus OX=10090 GN=Tln2 PE=1 SV=3 0.021 2.144 1 1 2 1 2375 253.5 5.8 1 1 1 1 29347.35352 201247.9688 244166.4375 1 1 1 cell organization and biogenesis cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379" 70549 Tln2 9 Focal adhesion; Platelet activation; HTLV-I infection; Rap1 signaling pathway 0 High Q91YR1 Twinfilin-1 OS=Mus musculus OX=10090 GN=Twf1 PE=1 SV=2 0.003 3.541 6 2 2 2 350 40.1 6.67 1 1 1 1 243255.1953 1001338.406 706431.5 2 2 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol catalytic activity;nucleotide binding;protein binding Pf00241 19230 ENSMUSG00000022451.12 Twf1 15 0 High O89051 Integral membrane protein 2B OS=Mus musculus OX=10090 GN=Itm2b PE=1 SV=1 0.003 3.42 11 2 2 2 266 30.2 5.3 1 1 1 1 417898.5 500933.25 1908250.063 2 1 2 regulation of biological process;response to stimulus endosome;extracellular;Golgi;membrane nucleotide binding;protein binding Pf04089 16432 ENSMUSG00000022108.7 Itm2b 14 0 Medium Q9CQR6 Serine/threonine-protein phosphatase 6 catalytic subunit OS=Mus musculus OX=10090 GN=Ppp6c PE=1 SV=1 0.023 2.114 9 1 2 1 305 35.1 5.69 1 1 1 1 227484.7344 312469.8125 1 1 metabolic process cytoplasm;cytosol catalytic activity;metal ion binding Pf00149 67857 ENSMUSG00000026753.5 Ppp6c 2 COPII (Coat Protein 2) Mediated Vesicle Transport 0 Medium Q09324 "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase OS=Mus musculus OX=10090 GN=Gcnt1 PE=1 SV=2" 0.028 1.674 2 1 2 1 428 49.8 8.34 1 2 6451904.375 29367643.5 31453338 1 1 1 metabolic process;response to stimulus Golgi;membrane catalytic activity Pf02485 14537 ENSMUSG00000038843.17 Gcnt1 19 O-linked glycosylation of mucins Metabolic pathways; Mucin type O-glycan biosynthesis 0 High P02463 Collagen alpha-1(IV) chain OS=Mus musculus OX=10090 GN=Col4a1 PE=1 SV=4 0.002 4.335 1 1 2 1 1669 160.6 8.24 1 1 1 1 993836.4375 1409117.5 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus extracellular protein binding;structural molecule activity "Pf01391, Pf01413" 12826 ENSMUSG00000031502.11 Col4a1 8 Anchoring fibril formation; Laminin interactions; Crosslinking of collagen fibrils; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Non-integrin membrane-ECM interactions; Signaling by PDGF AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q3B7Z2 Oxysterol-binding protein 1 OS=Mus musculus OX=10090 GN=Osbp PE=1 SV=3 0 5.274 3 2 2 2 805 88.7 7.2 2 2 175723.5625 758871.125 765871.5625 1 1 1 regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus protein binding;transporter activity "Pf00169, Pf01237, Pf15406, Pf15409, Pf15413" 76303 ENSMUSG00000024687.10 Osbp 19 Synthesis of bile acids and bile salts; Sphingolipid de novo biosynthesis 0 High A0A286YCQ5 Nidogen-2 (Fragment) OS=Mus musculus OX=10090 GN=Nid2 PE=1 SV=1 0 4.858 2 2 2 2 1171 128.4 5.76 1 1 1 1 347762.4688 273875.875 1 1 0 High Q9CQZ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Mus musculus OX=10090 GN=Ndufa6 PE=1 SV=1 0 5.965 19 2 2 2 131 15.3 10.11 1 1 1 1 396962.625 1610714.625 1452764.063 1 2 2 metabolic process;response to stimulus;transport membrane;mitochondrion "Pf05347, Pf13232, Pf13233" 67130 ENSMUSG00000022450.5 Ndufa6 15 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High A0A0R4J094 Fumarylacetoacetate hydrolase domain-containing 2A OS=Mus musculus OX=10090 GN=Fahd2a PE=1 SV=1 0.002 3.876 8 2 2 2 313 34.7 8.16 1 1 1 1 215053.5625 821760.125 2420929 1 1 2 metabolic process mitochondrion catalytic activity;metal ion binding Pf01557 68126 ENSMUSG00000027371.10 Fahd2a 2 0 High A2AKD7 Alpha-1-syntrophin OS=Mus musculus OX=10090 GN=Snta1 PE=1 SV=1 0 5.499 3 2 2 1 499 53.2 6.8 1 1 1 1 147010.3594 330702.8438 561747.1875 1 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00169, Pf00595" 20648 ENSMUSG00000027488.12 Snta1 2 0 High P51906 Excitatory amino acid transporter 3 OS=Mus musculus OX=10090 GN=Slc1a1 PE=1 SV=2 0 6.156 3 1 2 1 523 56.7 6.11 1 1 1 1 1980892 1708753.5 1 1 cell organization and biogenesis;regulation of biological process;transport membrane metal ion binding;protein binding;transporter activity Pf00375 20510 ENSMUSG00000024935.10 Slc1a1 19 Transport of inorganic cations/anions and amino acids/oligopeptides; Glutamate Neurotransmitter Release Cycle Protein digestion and absorption; Glutamatergic synapse 0 High Q91VM9 "Inorganic pyrophosphatase 2, mitochondrial OS=Mus musculus OX=10090 GN=Ppa2 PE=1 SV=1" 0.003 3.205 10 2 2 2 330 38.1 6.98 1 1 1 1 241340.6875 627400.0625 1188897.5 1 1 1 metabolic process cytoplasm;mitochondrion catalytic activity;metal ion binding Pf00719 74776 ENSMUSG00000028013.16 Ppa2 3 Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis Oxidative phosphorylation 0 High Q6PDN3 "Myosin light chain kinase, smooth muscle OS=Mus musculus OX=10090 GN=Mylk PE=1 SV=3" 0.002 4.491 1 2 2 2 1941 212.8 6.25 1 1 1 1 734327.875 1664877.688 1357925.563 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00041, Pf00047, Pf00069, Pf07679, Pf07714, Pf13895, Pf13927" 107589 Mylk 16 0 High Q62241 U1 small nuclear ribonucleoprotein C OS=Mus musculus OX=10090 GN=Snrpc PE=1 SV=1 0 5.572 13 2 2 2 159 17.4 9.67 2 2 1464452.875 1925767 1295822.75 1 1 1 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding Pf06220 20630 ENSMUSG00000024217.9 Snrpc 17 mRNA Splicing - Major Pathway Spliceosome 0 High Q8BTI8 Serine/arginine repetitive matrix protein 2 OS=Mus musculus OX=10090 GN=Srrm2 PE=1 SV=3 0.002 4.264 1 2 2 1 2703 294.7 12.03 1 1 1 1 164382.5938 559456.4375 758732.75 1 1 1 metabolic process nucleus;spliceosomal complex protein binding;RNA binding 75956 ENSMUSG00000039218.16 Srrm2 17 mRNA Splicing - Major Pathway 1 High Q9WUR9 "Adenylate kinase 4, mitochondrial OS=Mus musculus OX=10090 GN=Ak4 PE=1 SV=1" 0.003 3.502 9 2 2 2 223 25 7.53 1 1 1 1 646154.5313 1769013.188 1821020.875 2 2 2 metabolic process;response to stimulus mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00406, Pf05191, Pf13207, Pf13238, Pf13671" 11639 ENSMUSG00000028527.18 Ak4 4 Interconversion of nucleotide di- and triphosphates Thiamine metabolism; Metabolic pathways; Purine metabolism 0 High P34884 Macrophage migration inhibitory factor OS=Mus musculus OX=10090 GN=Mif PE=1 SV=2 0.01 2.791 8 1 2 1 115 12.5 7.34 1 1 1 1 952977.5 1283996.625 1306514.75 1 1 1 cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;nucleus catalytic activity;protein binding Pf01187 17319 ENSMUSG00000033307.7 Mif 10 Cell surface interactions at the vascular wall; Neutrophil degranulation Phenylalanine metabolism; Tyrosine metabolism 0 High Q9R1K9 Centrin-2 OS=Mus musculus OX=10090 GN=Cetn2 PE=1 SV=1 0 7.766 24 2 2 2 172 19.8 5 1 1 1 1 168052.9375 895526.6875 1232172.75 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13499, Pf13833" 26370 ENSMUSG00000031347.12 Cetn2 X Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; DNA Damage Recognition in GG-NER; Loss of Nlp from mitotic centrosomes; Formation of Incision Complex in GG-NER; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins Nucleotide excision repair 0 High D3YY50 Copper homeostasis protein cutC homolog (Fragment) OS=Mus musculus OX=10090 GN=Cutc PE=1 SV=1 0 6.37 13 2 2 2 254 27.1 6.68 1 1 1 1 19448.95898 1728065.531 1108357.219 1 2 2 metal ion binding Pf03932 ENSMUSG00000025193.14 19 0 High Q3TYE1 Casein kinase I isoform epsilon OS=Mus musculus OX=10090 GN=Csnk1e PE=1 SV=1 0.003 3.682 6 2 2 2 368 42.2 8.9 2 2 349920.8125 2141970.5 2416894.688 2 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf01636, Pf07714" 27373 ENSMUSG00000022433.18 Csnk1e 15 0 High P10833 Ras-related protein R-Ras OS=Mus musculus OX=10090 GN=Rras PE=1 SV=1 0.003 3.549 5 1 2 1 218 23.7 6.79 1 1 1 1 418130.7188 978663.375 1656939.25 1 1 1 cell differentiation;regulation of biological process;response to stimulus cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00071, Pf08477" 20130 ENSMUSG00000038387.9 Rras 7 CREB phosphorylation through the activation of Ras; Sema4D mediated inhibition of cell attachment and migration Phospholipase D signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Ras signaling pathway; Axon guidance; HTLV-I infection; Proteoglycans in cancer; Rap1 signaling pathway; cAMP signaling pathway; Tight junction 0 High F6VT60 AFG1-like ATPase (Fragment) OS=Mus musculus OX=10090 GN=Afg1l PE=1 SV=1 0.003 3.332 5 2 2 2 348 40 6.87 2 2 377410.8125 1430650.25 1 2 mitochondrion nucleotide binding Pf03969 ENSMUSG00000038302.14 10 0 Medium A2AS03 Helicase with zinc finger domain 2 OS=Mus musculus OX=10090 GN=Helz2 PE=1 SV=1 0.021 2.172 0 1 2 1 2970 333.8 8 1 1 1 1 1455046.875 2498331.75 1 1 metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;RNA binding "Pf00773, Pf04851, Pf09848, Pf13086, Pf13087, Pf13245, Pf13538, Pf13604" 229003 ENSMUSG00000027580.17 BC006779; Helz2 2 0 Low H3BK68 tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) OS=Mus musculus OX=10090 GN=Trmt1 PE=1 SV=1 0.053 1.433 12 1 2 1 221 24.1 5.66 1 1 1 1 3394188.25 5354942.5 2485023.25 1 1 1 metabolic process catalytic activity;RNA binding "Pf02005, Pf12847" ENSMUSG00000001909.15 8 0 Medium G5E881 "Phosphatidate cytidylyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Tamm41 PE=1 SV=1" 0.018 2.235 4 1 2 1 337 37.9 9.11 1 1 1 1 140221.6719 643903.25 811863.5625 1 1 1 Met-loss+Acetyl [N-Term] metabolic process membrane;mitochondrion catalytic activity Pf09139 68971 ENSMUSG00000030316.13 Tamm41 6 0 High Q9DC70 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs7 PE=1 SV=1" 0 9.792 18 2 2 2 224 24.7 9.92 1 1 1 1 1677382.25 915028.625 2 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding Pf01058 75406 ENSMUSG00000020153.14 Ndufs7 10 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P61211 ADP-ribosylation factor-like protein 1 OS=Mus musculus OX=10090 GN=Arl1 PE=1 SV=1 0.003 3.529 8 2 2 2 181 20.4 5.72 1 1 1 1 718324.625 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 104303 ENSMUSG00000060904.14 Arl1 10 Retrograde transport at the Trans-Golgi-Network 0 Medium A0A0G2JF33 Protein FAM133B OS=Mus musculus OX=10090 GN=Fam133b PE=1 SV=1 0.021 2.153 7 1 2 1 109 13 10.42 1 1 1 1 2853086.75 5631276 5261353.5 1 1 1 ENSMUSG00000058503.11 5 0 High O35857 Mitochondrial import inner membrane translocase subunit TIM44 OS=Mus musculus OX=10090 GN=Timm44 PE=1 SV=2 0 5.567 6 2 2 2 452 51.1 8.13 2 2 323574.1875 724820.5 1 1 transport membrane;mitochondrion;organelle lumen nucleotide binding;protein binding Pf04280 21856 ENSMUSG00000002949.15 Timm44 8 0 High Q4FK66 Pre-mRNA-splicing factor 38A OS=Mus musculus OX=10090 GN=Prpf38a PE=1 SV=1 0 5.357 9 2 2 2 312 37.4 10.01 1 1 1 1 1176550.094 688455.875 910403.9375 2 1 1 metabolic process membrane;nucleus;spliceosomal complex RNA binding Pf03371 230596 ENSMUSG00000063800.5 Prpf38a 4 mRNA Splicing - Major Pathway Spliceosome 0 High D3Z227 Catechol O-methyltransferase (Fragment) OS=Mus musculus OX=10090 GN=Comt PE=1 SV=1 0.002 3.749 15 1 2 1 171 18.9 6.93 1 1 1 1 557146.5 1 cell communication;metabolic process;response to stimulus mitochondrion catalytic activity "Pf01596, Pf12847, Pf13578, Pf13659" ENSMUSG00000000326.12; ENSMUSG00000098892.8 16; CHR_MG3833_MG4220_PATCH 0 High P14431 "H-2 class I histocompatibility antigen, Q9 alpha chain (Fragment) OS=Mus musculus OX=10090 GN=H2-Q9 PE=3 SV=1" 0 6.493 10 2 2 2 200 23 5.64 2 2 5116995.5 2 defense response;regulation of biological process;response to stimulus cell surface;membrane protein binding Pf00129 110558 H2-Q9 17 0 High Q9DCS2 Methyltransferase-like 26 OS=Mus musculus OX=10090 GN=Mettl26 PE=1 SV=1 0 7.811 20 2 2 2 204 22.7 6.52 1 1 1 1 1244302.375 1 catalytic activity "Pf05175, Pf06080, Pf12847, Pf13649, Pf13659" 68347 ENSMUSG00000025731.15 0610011F06Rik; Mettl26 17 0 High E9Q4T8 Cullin-3 OS=Mus musculus OX=10090 GN=Cul3 PE=1 SV=1 0.002 4.189 2 1 2 1 702 81.1 8.47 1 1 1 1 827942.0625 1897700.25 1 1 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;Golgi;nucleus protein binding "Pf00888, Pf10557" ENSMUSG00000004364.14 1 0 High D6RGM7 Katanin p60 ATPase-containing subunit A-like 2 OS=Mus musculus OX=10090 GN=Katnal2 PE=1 SV=1 0.003 3.216 3 1 2 1 372 42 8.91 1 1 1 1 335566 1469833 2270597.5 1 1 1 metabolic process;response to stimulus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf07724, Pf07726, Pf07728, Pf08513, Pf13401, Pf13479" ENSMUSG00000025420.13 18 0 High E9PUK6 Serine/arginine repetitive matrix protein 1 OS=Mus musculus OX=10090 GN=Srrm1 PE=1 SV=1 0 8.575 3 2 2 1 923 104.2 11.85 1 1 1 1 1048007.563 831768.5625 1 1 metabolic process nucleus;spliceosomal complex DNA binding;RNA binding "Pf01480, Pf15449" 51796 ENSMUSG00000028809.16 Srrm1 4 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; RNA transport 1 Low E9Q1W3 Nebulin OS=Mus musculus OX=10090 GN=Neb PE=1 SV=1 0.054 1.427 0 1 2 1 7152 828.1 9.07 1 1 1 1 21872430 19371056 6134718 1 1 1 cell organization and biogenesis;regulation of biological process protein binding "Pf00880, Pf14604" 17996 ENSMUSG00000026950.17 Neb 2 Striated Muscle Contraction 0 Medium Q01320 DNA topoisomerase 2-alpha OS=Mus musculus OX=10090 GN=Top2a PE=1 SV=2 0.017 2.406 1 1 2 1 1528 172.7 8.6 1 1 1 1 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00204, Pf00521, Pf01751, Pf02449, Pf02518, Pf08070" 21973 ENSMUSG00000020914.17 Top2a 11 SUMOylation of DNA replication proteins Platinum drug resistance 0 High E9Q0P9 "Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment) OS=Mus musculus OX=10090 GN=Serpinb6a PE=1 SV=1" 0 4.877 12 2 2 2 193 21.3 5.95 1 1 1 1 Pf00079 ENSMUSG00000060147.15 13 0 High Q9QZD8 Mitochondrial dicarboxylate carrier OS=Mus musculus OX=10090 GN=Slc25a10 PE=1 SV=2 0 6.647 9 2 2 2 287 31.7 9.32 2 2 transport membrane;mitochondrion;nucleus transporter activity Pf00153 27376; 66838 ENSMUSG00000025792.9 Slc25a10; 0610009L18Rik 11 Organic anion transporters; Sulfide oxidation to sulfate; Gluconeogenesis Proximal tubule bicarbonate reclamation 0 High Q5U4H9 Nuclear receptor coactivator 4 OS=Mus musculus OX=10090 GN=Ncoa4 PE=1 SV=1 0 8.708 4 2 2 2 625 70.3 5.4 1 1 1 1 572647.5 840303 474056.625 1 1 1 cellular homeostasis;response to stimulus;transport mitochondrion;vacuole Pf12489 27057 ENSMUSG00000056234.14 Ncoa4 14 Pathways in cancer; Thyroid cancer 0 High A0A571BF54 Voltage-gated potassium channel subunit beta-2 OS=Mus musculus OX=10090 GN=Kcnab2 PE=1 SV=1 0 5.345 14 2 2 2 398 44 9.13 2 2 372624.0938 1 0 High A0A5F8MPL9 Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 0.003 3.384 1 2 2 2 2055 235.2 7.25 1 1 1 1 143255.75 320385.0938 734061.7813 1 1 2 0 Medium Q8BH59 Calcium-binding mitochondrial carrier protein Aralar1 OS=Mus musculus OX=10090 GN=Slc25a12 PE=1 SV=1 0.018 2.322 1 1 2 1 677 74.5 8.25 1 1 1 1 55776.37891 190603.2188 218894.7969 1 1 1 response to stimulus;transport membrane;mitochondrion metal ion binding;transporter activity "Pf00153, Pf13499" 78830 ENSMUSG00000027010.16 Slc25a12 2 Gluconeogenesis 0 High Q3TQC7 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Mus musculus OX=10090 GN=Entpd5 PE=1 SV=1 0 5.4 6 2 2 2 452 49.8 5.47 1 1 1 1 163121.5313 484761.5938 605816.6875 1 1 1 cell growth;cell proliferation;metabolic process;regulation of biological process endoplasmic reticulum;extracellular;membrane catalytic activity Pf01150 12499 ENSMUSG00000021236.16 Entpd5 12 0 Medium Q99MU3 Double-stranded RNA-specific adenosine deaminase OS=Mus musculus OX=10090 GN=Adar PE=1 SV=2 0.023 1.988 1 1 2 1 1178 130.4 8.7 1 1 1 1 22845806 39098760 64334676 1 1 1 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00035, Pf01978, Pf02137, Pf02295" 56417 ENSMUSG00000027951.16 Adar 3 Formation of editosomes by ADAR proteins; C6 deamination of adenosine Influenza A; Cytosolic DNA-sensing pathway; Measles 0 High Q91Z31 Polypyrimidine tract-binding protein 2 OS=Mus musculus OX=10090 GN=Ptbp2 PE=1 SV=2 0.003 3.378 2 1 2 1 531 57.5 8.66 1 1 1 1 110839.9453 593419.9375 588627.1875 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 56195 ENSMUSG00000028134.11 Ptbp2 3 0 High Q569Z6 Thyroid hormone receptor-associated protein 3 OS=Mus musculus OX=10090 GN=Thrap3 PE=1 SV=1 0 4.892 3 2 2 2 951 108.1 10.17 1 1 1 1 610170.9375 1 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;nucleotide binding;protein binding;receptor activity;RNA binding Pf15440 230753 ENSMUSG00000043962.16 Thrap3 4 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High P11031 Activated RNA polymerase II transcriptional coactivator p15 OS=Mus musculus OX=10090 GN=Sub1 PE=1 SV=3 0.003 3.267 9 1 2 1 127 14.4 9.6 1 1 1 1 594986.9375 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf02229 20024 ENSMUSG00000022205.15 Sub1 15 0 High Q8K1Y2 Serine/threonine-protein kinase D3 OS=Mus musculus OX=10090 GN=Prkd3 PE=1 SV=1 0 5.838 2 1 2 1 889 100 6.81 1 1 1 1 28571.99023 358128.5938 326129.1563 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding "Pf00069, Pf00130, Pf00169, Pf07714, Pf14531" 75292 ENSMUSG00000024070.15 Prkd3 17 Sphingolipid de novo biosynthesis Rap1 signaling pathway; Aldosterone synthesis and secretion 0 High Q9ESU6 Bromodomain-containing protein 4 OS=Mus musculus OX=10090 GN=Brd4 PE=1 SV=2 0 5.795 1 1 2 1 1400 155.8 9.19 1 1 1 1 759332.875 1074911.125 779538.0625 1 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;protein binding Pf00439 57261 ENSMUSG00000024002.16 Brd4 17 0 High P23116 Eukaryotic translation initiation factor 3 subunit A OS=Mus musculus OX=10090 GN=Eif3a PE=1 SV=5 0.006 2.993 2 2 2 2 1344 161.8 6.77 1 1 1 1 195881.7344 863843.9063 1282143.844 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding Pf01399 13669 ENSMUSG00000024991.7 Eif3a 19 "Formation of a pool of free 40S subunits; L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit" RNA transport 0 High E9PVD5 GTPase NRas OS=Mus musculus OX=10090 GN=Nras PE=4 SV=1 0.003 3.425 24 1 2 1 46 5 4.6 1 1 1 1 637157.3125 1416447.875 1718418.25 1 1 1 regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding Pf00071 ENSMUSG00000027852.14 3 "NCAM signaling for neurite out-growth; MET activates RAS signaling; FRS-mediated FGFR3 signaling; SHC1 events in EGFR signaling; SHC-mediated cascade:FGFR3; Downstream signal transduction; RAF activation; Interleukin-20 family signaling; FRS-mediated FGFR2 signaling; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; EGFR Transactivation by Gastrin; SHC1 events in ERBB4 signaling; MAP2K and MAPK activation; CD209 (DC-SIGN) signaling; DAP12 signaling; GRB2 events in EGFR signaling; Signaling by SCF-KIT; VEGFR2 mediated cell proliferation; SHC-mediated cascade:FGFR4; FRS-mediated FGFR4 signaling; FCERI mediated MAPK activation; Tie2 Signaling; Activation of RAS in B cells; Signaling by GPCR; Neutrophil degranulation; SHC-mediated cascade:FGFR2; Regulation of RAS by GAPs; GRB2 events in ERBB2 signaling; Negative regulation of MAPK pathway; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR1; p38MAPK events" 0 High F8WJ64 Acyl carrier protein (Fragment) OS=Mus musculus OX=10090 GN=Ndufab1 PE=1 SV=1 0.003 3.396 12 1 2 1 128 14.4 4.77 1 1 1 1 548116.5625 780084.75 1490530.125 1 1 2 metabolic process mitochondrion Pf00550 ENSMUSG00000030869.11 7 0 High E9PZ88 Alpha-mannosidase 2C1 OS=Mus musculus OX=10090 GN=Man2c1 PE=1 SV=1 0.003 3.223 2 1 2 1 940 104.6 6.46 1 1 1 1 125213.0313 322710.1875 431116.4375 1 1 1 metabolic process catalytic activity;metal ion binding "Pf01074, Pf07748, Pf09261" ENSMUSG00000032295.15 9 0 High P01797 Ig heavy chain V-III region U61 OS=Mus musculus OX=10090 PE=1 SV=1 0.003 3.736 24 2 2 2 113 12.7 7.28 2 2 1643454.375 507965.8125 944780.0625 2 1 1 Pf07686 0 High G3UZI2 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus OX=10090 GN=Syncrip PE=1 SV=1 0 5.164 5 2 2 2 527 58.7 7.56 1 1 1 1 456967.4375 556197.0625 2379056.063 1 1 2 RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000032423.12 9 0 Medium D3YTZ8 Ras-related protein Rab-15 OS=Mus musculus OX=10090 GN=Rab15 PE=1 SV=1 0.017 2.313 7 1 2 1 166 19.2 5.3 1 2 1722668.125 4041333.75 1 1 regulation of biological process;response to stimulus;transport membrane catalytic activity;nucleotide binding;protein binding "Pf00071, Pf08477, Pf13212" 104886 ENSMUSG00000021062.15 Rab15 12 0 High A0A1L1SUN1 60S ribosomal protein L29 (Fragment) OS=Mus musculus OX=10090 GN=Rpl29 PE=1 SV=1 0 4.649 20 2 2 2 94 10.5 11.72 1 1 1 1 2398154.125 4746922.5 3339085.25 2 2 1 metabolic process ribosome structural molecule activity ENSMUSG00000048758.14 9 0 High A2AAW9 "Eukaryotic translation initiation factor 2 subunit 3, X-linked OS=Mus musculus OX=10090 GN=Eif2s3x PE=1 SV=1" 0 5.037 12 2 2 2 344 37.2 7.24 2 2 129638.9063 488285.8438 1530419.875 1 1 1 metabolic process cytoplasm catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03144" 26905 ENSMUSG00000035150.15 Eif2s3x X 0 High A0A0U1RPA0 Pleckstrin homology domain-containing family A member 7 (Fragment) OS=Mus musculus OX=10090 GN=Plekha7 PE=1 SV=1 0.009 2.867 1 1 2 1 1212 137.2 9.28 1 1 1 1 296632.0625 285304.2813 738146.3125 1 1 1 metabolic process "Pf00169, Pf02463, Pf04111, Pf07798, Pf14992, Pf15409, Pf15413" ENSMUSG00000045659.18 7 0 High Q64277 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 OS=Mus musculus OX=10090 GN=Bst1 PE=1 SV=1 0 6.232 9 2 2 2 311 34.6 5.8 1 1 1 1 286062.8438 1196848.578 2591689.5 1 2 2 regulation of biological process membrane catalytic activity Pf02267 12182 Bst1 5 Pancreatic secretion; Metabolic pathways; Nicotinate and nicotinamide metabolism; Salivary secretion 0 High Q9ESW8 Pyroglutamyl-peptidase 1 OS=Mus musculus OX=10090 GN=Pgpep1 PE=1 SV=1 0 5.552 10 1 2 1 209 22.9 5.39 1 1 1 1 348240.6563 440400.7188 1 1 metabolic process cytoplasm;cytosol catalytic activity Pf01470 66522 ENSMUSG00000056204.8 Pgpep1 8 0 High Q3UPL0 Protein transport protein Sec31A OS=Mus musculus OX=10090 GN=Sec31a PE=1 SV=2 0 5.813 2 2 2 2 1230 133.5 6.76 2 2 171013.1094 899549.875 1930561 1 2 2 cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane protein binding "Pf03154, Pf12931" 69162 ENSMUSG00000035325.16 Sec31a 5 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 Low Q9QVP9 Protein-tyrosine kinase 2-beta OS=Mus musculus OX=10090 GN=Ptk2b PE=1 SV=2 0.086 1.247 1 1 2 1 1009 115.7 6.35 1 1 1 1 1205416.75 1434608.875 1984236.125 1 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf00069, Pf00373, Pf03623, Pf07714" 19229 ENSMUSG00000059456.13 Ptk2b 14 Signal regulatory protein family interactions; VEGFA-VEGFR2 Pathway; Interleukin-2 family signaling; Interleukin-7 signaling Leukocyte transendothelial migration; Phospholipase D signaling pathway; Chemokine signaling pathway; Hepatitis B; Calcium signaling pathway; GnRH signaling pathway; Natural killer cell mediated cytotoxicity 0 High Q5SSK3 "Transcription elongation factor, mitochondrial OS=Mus musculus OX=10090 GN=Tefm PE=1 SV=1" 0 9.507 9 2 2 2 364 41.8 9.51 1 1 1 1 575231.0625 768763.75 1 1 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen enzyme regulator activity;RNA binding Pf12836 68550 ENSMUSG00000046909.9 Tefm 11 0 Medium B2RUJ2 Erbb2ip protein OS=Mus musculus OX=10090 GN=Erbin PE=1 SV=1 0.01 2.494 3 2 2 2 1294 145 5.41 2 2 294492.7813 1 regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus protein binding "Pf00595, Pf12799, Pf13855" 59079 ENSMUSG00000021709.14 Erbb2ip; Erbin 13 0 High Q99KP3 Lambda-crystallin homolog OS=Mus musculus OX=10090 GN=Cryl1 PE=1 SV=3 0.003 3.733 8 2 2 2 319 35.2 5.86 1 1 1 1 813213.1875 1 metabolic process cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding "Pf00725, Pf02737" 68631 ENSMUSG00000021947.10 Cryl1 14 Catabolism of glucuronate to xylulose-5-phosphate Metabolic pathways; Pentose and glucuronate interconversions 0 High P61202 COP9 signalosome complex subunit 2 OS=Mus musculus OX=10090 GN=Cops2 PE=1 SV=1 0.002 3.898 6 1 2 1 443 51.6 5.53 1 1 1 1 538626.9375 1 cell differentiation;cell proliferation;metabolic process;regulation of biological process cytoplasm;nucleus protein binding "Pf01399, Pf10075" 12848 ENSMUSG00000027206.13 Cops2 2 DNA Damage Recognition in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis 0 Low Q80YN3 Breast carcinoma-amplified sequence 1 homolog OS=Mus musculus OX=10090 GN=Bcas1 PE=1 SV=3 0.097 1.117 2 1 2 1 633 67.3 6.21 1 1 1 1 314146.0313 2836078.75 3928603.75 1 1 1 cytoplasm;cytosol protein binding 76960 ENSMUSG00000013523.13 Bcas1 2 0 High Q9JK53 Prolargin OS=Mus musculus OX=10090 GN=Prelp PE=1 SV=2 0 5.112 7 2 2 2 378 43.3 9.54 1 1 1 1 152605.7656 950240.3438 1660008.5 2 2 1 cell organization and biogenesis extracellular protein binding;structural molecule activity "Pf01462, Pf12799, Pf13855" 116847 ENSMUSG00000041577.5 Prelp 1 Keratan sulfate degradation; Keratan sulfate biosynthesis 0 High A0A0J9YV30 Paxillin OS=Mus musculus OX=10090 GN=Pxn PE=1 SV=1 0 7.554 5 2 2 2 424 46.5 6.95 1 1 1 1 233965.5938 847391.625 1083095.75 1 1 1 cytoskeleton metal ion binding "Pf00412, Pf03535" ENSMUSG00000029528.18 5 0 Medium B1AU76 Nuclear autoantigenic sperm protein OS=Mus musculus OX=10090 GN=Nasp PE=1 SV=1 0.023 2.009 6 1 2 1 448 48.7 4.45 1 1 1 1 8350697 4111837.5 7098607.5 1 1 1 cell organization and biogenesis;cell proliferation;metabolic process;transport cytoplasm;nucleus protein binding "Pf10516, Pf13414, Pf13424" 50927 ENSMUSG00000028693.15 Nasp 4 0 High P58059 "28S ribosomal protein S21, mitochondrial OS=Mus musculus OX=10090 GN=Mrps21 PE=1 SV=1" 0 6.213 15 1 2 1 87 10.6 10.32 1 1 1 1 608008.375 1302687 2009711.375 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity 66292 ENSMUSG00000054312.6 Mrps21 3 Ribosome 0 Medium Q8BK64 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus OX=10090 GN=Ahsa1 PE=1 SV=2 0.026 1.843 4 1 2 1 338 38.1 5.53 1 1 1 1 587037.625 1288660.625 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum enzyme regulator activity;protein binding "Pf08327, Pf09229" 217737 ENSMUSG00000021037.6 Ahsa1 12 0 Medium A0A5F8MPX1 Histone acetyltransferase OS=Mus musculus OX=10090 GN=Kat6a PE=1 SV=1 0.049 1.44 1 1 2 1 2053 230.4 5.66 1 2 9569739.25 5926659.875 5789599.75 1 1 1 0 High P12815 Programmed cell death protein 6 OS=Mus musculus OX=10090 GN=Pdcd6 PE=1 SV=2 0 5.435 10 2 2 2 191 21.9 5.4 1 1 1 1 361565.25 1236178.25 3224540.688 2 1 2 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00036, Pf13405, Pf13499, Pf13833" 18570 ENSMUSG00000021576.5 Pdcd6 13 0 High Q99PM0 Microfibril-associated glycoprotein 1 OS=Mus musculus OX=10090 GN=Mfap2 PE=1 SV=1 0.002 4.235 5 1 2 1 185 20.8 4.89 1 1 1 1 346337.875 536892 2397284.5 1 1 1 cell differentiation extracellular protein binding Pf05507 17150 ENSMUSG00000060572.17 Mfap2 4 Molecules associated with elastic fibres 0 Medium Q9CQC7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Mus musculus OX=10090 GN=Ndufb4 PE=1 SV=3 0.023 1.947 10 1 2 1 129 15.1 9.89 1 1 1 1 355029.5313 239487.2188 451698.1875 1 1 1 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity Pf07225 100041273; 68194; 100042503 ENSMUSG00000022820.3 Gm3244; Ndufb4; Gm3873 15; 16; 19 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P62334 26S proteasome regulatory subunit 10B OS=Mus musculus OX=10090 GN=Psmc6 PE=1 SV=1 0 5.223 4 1 2 1 389 44.1 7.49 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401" 67089 ENSMUSG00000021832.7 Psmc6 14 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High Q8VE22 "28S ribosomal protein S23, mitochondrial OS=Mus musculus OX=10090 GN=Mrps23 PE=1 SV=1" 0.002 4.088 11 2 2 2 177 20.3 8.59 2 2 675606.75 1667751.906 1 2 metabolic process cytoskeleton;membrane;mitochondrion;ribosome RNA binding;structural molecule activity "Pf10484, Pf13741" 64656 ENSMUSG00000023723.17; ENSMUSG00000098375.6 Mrps23 11; CHR_MG3829_PATCH Mitochondrial translation termination; Mitochondrial translation elongation 0 High A0A338P7L8 Charged multivesicular body protein 2b OS=Mus musculus OX=10090 GN=Chmp2b PE=1 SV=1 0.004 3.116 5 1 2 1 209 23.5 8.81 1 1 1 1 218547.75 896334.75 1131198.5 1 1 1 0 Medium P97326 Cadherin-6 OS=Mus musculus OX=10090 GN=Cdh6 PE=1 SV=2 0.023 1.926 1 1 2 1 790 88.3 5 1 1 1 1 634196.0938 5673417 10818628.66 1 1 1 regulation of biological process;response to stimulus membrane metal ion binding "Pf00028, Pf01049" 12563 ENSMUSG00000039385.4 Cdh6 15 Adherens junctions interactions 0 High Q9EP53 Hamartin OS=Mus musculus OX=10090 GN=Tsc1 PE=1 SV=1 0.003 3.38 2 2 2 2 1161 128.7 6.37 2 2 166639.0781 549578 1518345.125 1 1 2 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;protein binding "Pf00261, Pf01576, Pf02388, Pf02463, Pf03357, Pf04012, Pf04111, Pf04156, Pf04388, Pf05483, Pf05557, Pf05622, Pf08317, Pf09789, Pf12128, Pf12718, Pf12795, Pf13851, Pf13868, Pf14988" 64930 ENSMUSG00000026812.16 Tsc1 2 Inhibition of TSC complex formation by PKB; TBC/RABGAPs; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK mTOR signaling pathway; Phospholipase D signaling pathway; Insulin signaling pathway; Longevity regulating pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Choline metabolism in cancer 0 High F6RV17 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Mus musculus OX=10090 GN=Ppp2r2d PE=1 SV=2 0 5.811 5 1 2 1 288 33.4 6.65 1 1 1 1 195744.3438 941348.8125 1593325.25 1 1 1 cell division;metabolic process;regulation of biological process cytoplasm;cytosol catalytic activity;enzyme regulator activity;protein binding 52432 ENSMUSG00000041769.13 Ppp2r2d 7 0 High F8WGX5 DmX-like protein 1 OS=Mus musculus OX=10090 GN=Dmxl1 PE=1 SV=1 0.003 3.276 1 2 2 1 3025 337.2 6.42 2 2 626601.375 446251.0625 1 1 protein binding "Pf00400, Pf12234" ENSMUSG00000037416.12 18 0 High Q9EQI8 "39S ribosomal protein L46, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl46 PE=1 SV=1" 0 11.291 7 1 2 1 283 32.1 7.4 1 1 1 1 368847.625 1 mitochondrion;ribosome catalytic activity;structural molecule activity Pf11788 67308 ENSMUSG00000030612.6 Mrpl46 7 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q9D8I3 Glyoxalase domain-containing protein 5 OS=Mus musculus OX=10090 GN=Glod5 PE=1 SV=1 0.003 3.343 7 1 2 1 148 16.6 5.34 1 1 1 1 45170.91797 696084.9375 821507.125 1 1 1 "Pf00903, Pf12681" 69824 ENSMUSG00000031163.2 Glod5 X 0 High A0A0G2JF23 Malate dehydrogenase (Fragment) OS=Mus musculus OX=10090 GN=Mdh2 PE=1 SV=1 0.002 4.017 11 2 2 2 199 21 8.68 1 1 1 1 1276796.094 1128891.063 1854789.688 2 2 2 metabolic process membrane;mitochondrion catalytic activity "Pf00056, Pf02866" ENSMUSG00000019179.10 5 0 Medium E9PYK3 Protein mono-ADP-ribosyltransferase PARP4 OS=Mus musculus OX=10090 GN=Parp4 PE=1 SV=1 0.01 2.609 2 2 2 2 1969 216 6.07 1 1 1 1 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding "Pf00092, Pf00533, Pf00644, Pf06346, Pf08487, Pf13519, Pf13757, Pf13768" 328417 ENSMUSG00000054509.7 Parp4 14 Base excision repair; Apoptosis 0 High F8VQJ3 Laminin subunit gamma-1 OS=Mus musculus OX=10090 GN=Lamc1 PE=1 SV=1 0 4.991 1 2 2 2 1607 177.1 5.19 1 1 1 1 272632.7188 1 cell organization and biogenesis;cellular component movement;regulation of biological process cytoskeleton;extracellular catalytic activity;motor activity;protein binding;structural molecule activity "Pf00052, Pf00053, Pf00055, Pf00261, Pf01576, Pf04012, Pf05262, Pf05483, Pf05557, Pf05701, Pf06008, Pf06160, Pf08317, Pf10174, Pf12795, Pf13514, Pf13868, Pf13949" 226519 ENSMUSG00000026478.14 Lamc1 1 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); MET activates PTK2 signaling; Laminin interactions; Post-translational protein phosphorylation Focal adhesion; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Prion diseases; Amoebiasis 0 High G3UVV4 Hexokinase-1 OS=Mus musculus OX=10090 GN=Hk1 PE=1 SV=1 0 6.876 2 2 2 2 917 101.8 6.67 2 2 243778.5469 433281.375 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00349, Pf03727" 15275 ENSMUSG00000037012.18 Hk1 10 0 High P56402 Aquaporin-2 OS=Mus musculus OX=10090 GN=Aqp2 PE=1 SV=2 0.002 3.838 4 1 2 1 271 28.9 6.93 1 1 1 1 837813 2539457.75 3428550.25 1 1 1 cell communication;cell death;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane;vacuole protein binding;transporter activity Pf00230 11827 ENSMUSG00000023013.4 Aqp2 15 Vasopressin regulates renal water homeostasis via Aquaporins; Passive transport by Aquaporins Vasopressin-regulated water reabsorption 0 High Q8R081 Heterogeneous nuclear ribonucleoprotein L OS=Mus musculus OX=10090 GN=Hnrnpl PE=1 SV=2 0 7.932 6 2 2 2 586 63.9 8.1 1 1 1 1 263343.7813 527714.25 839427.9375 1 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 15388 ENSMUSG00000015165.16 Hnrnpl 7 mRNA Splicing - Major Pathway 0 High Q9D0T1 NHP2-like protein 1 OS=Mus musculus OX=10090 GN=Snu13 PE=1 SV=4 0 7.599 22 2 2 2 128 14.2 8.46 1 1 1 1 132738.0781 1786967.875 2878468.625 1 2 2 cell organization and biogenesis;metabolic process membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf01248 20826; 100862468 ENSMUSG00000063480.7 Nhp2l1; Snu13; LOC100862468 15; 4 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Major pathway of rRNA processing in the nucleolus and cytosol Spliceosome; Ribosome biogenesis in eukaryotes 0 High Q8R1G2 Carboxymethylenebutenolidase homolog OS=Mus musculus OX=10090 GN=Cmbl PE=1 SV=1 0.002 3.753 11 2 2 2 245 27.9 7.18 2 2 427195.625 611591.5625 877754.3125 1 1 1 metabolic process cytoplasm;cytosol catalytic activity "Pf00326, Pf00561, Pf01738, Pf03959, Pf12695, Pf12697" 69574 ENSMUSG00000022235.14 Cmbl 15 Phase I - Functionalization of compounds Metabolic pathways 0 High P54822 Adenylosuccinate lyase OS=Mus musculus OX=10090 GN=Adsl PE=1 SV=2 0.002 4.308 2 1 2 1 484 54.8 7.27 1 1 1 1 481460.8438 1013143 1391711.875 1 1 1 cell organization and biogenesis;metabolic process;response to stimulus cytosol;mitochondrion catalytic activity "Pf00206, Pf10397" 11564 ENSMUSG00000022407.9 Adsl 15 Purine ribonucleoside monophosphate biosynthesis "Metabolic pathways; Purine metabolism; Alanine, aspartate and glutamate metabolism" 0 High Q8VEA4 Mitochondrial intermembrane space import and assembly protein 40 OS=Mus musculus OX=10090 GN=Chchd4 PE=1 SV=1 0 6.913 17 2 2 2 139 15.5 4.32 2 2 623054.0938 2036367.5 2786291.875 2 2 2 metabolic process;regulation of biological process;response to stimulus;transport mitochondrion catalytic activity;protein binding Pf06747 72170 ENSMUSG00000034203.8 Chchd4 6 0 Low Q6DFV5 Probable helicase with zinc finger domain OS=Mus musculus OX=10090 GN=Helz PE=1 SV=2 0.054 1.428 1 1 2 1 1964 219.7 7.4 1 2 516252.125 2158672.25 1308639.375 1 1 1 membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00580, Pf00642, Pf02562, Pf04851, Pf07728, Pf13086, Pf13087, Pf13245, Pf13604" 78455 ENSMUSG00000020721.16 Helz 11 0 High Q99JI6 Ras-related protein Rap-1b OS=Mus musculus OX=10090 GN=Rap1b PE=1 SV=2 0.002 4.026 12 2 2 2 184 20.8 5.78 2 2 496470.0938 1057587.375 1 1 cell proliferation;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00009, Pf00071, Pf08477" 215449 ENSMUSG00000052681.8 Rap1b 10 p130Cas linkage to MAPK signaling for integrins; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Neutrophil degranulation; MET activates RAP1 and RAC1; Rap1 signalling Leukocyte transendothelial migration; MAPK signaling pathway; Pancreatic secretion; Ras signaling pathway; Focal adhesion; Long-term potentiation; Chemokine signaling pathway; Platelet activation; Neurotrophin signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Renal cell carcinoma 0 High P42208 Septin-2 OS=Mus musculus OX=10090 GN=Septin2 PE=1 SV=2 0 6.377 9 2 2 2 361 41.5 6.55 2 2 380590.2813 1363109.75 1 1 cell differentiation;cell division;cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;structural molecule activity "Pf00071, Pf00735, Pf01926" 18000 ENSMUSG00000026276.18; ENSMUSG00000112508.1 Sept2 1 Anchoring of the basal body to the plasma membrane Bacterial invasion of epithelial cells 0 High Q9CQW2 ADP-ribosylation factor-like protein 8B OS=Mus musculus OX=10090 GN=Arl8b PE=1 SV=1 0.003 3.62 5 1 2 1 186 21.5 8.43 1 1 1 1 786556.6875 488532.625 1 1 cell division;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439" 67166 ENSMUSG00000030105.8 Arl8b 6 0 High Q06185 "ATP synthase subunit e, mitochondrial OS=Mus musculus OX=10090 GN=Atp5me PE=1 SV=2" 0.003 3.697 17 1 2 1 71 8.2 9.35 1 1 1 1 398335.125 1264923.25 2594018.75 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf05680 11958 ENSMUSG00000050856.16 Atp5k 5 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Oxidative phosphorylation 0 High A0A498WGK2 Asparaginyl-tRNA synthetase OS=Mus musculus OX=10090 GN=Nars PE=4 SV=1 0.003 3.159 3 1 2 1 558 64.2 5.86 1 1 1 1 304889.75 434573.9375 996043.75 1 1 1 0 High P63085 Mitogen-activated protein kinase 1 OS=Mus musculus OX=10090 GN=Mapk1 PE=1 SV=3 0.003 3.431 6 2 2 2 358 41.2 6.98 1 1 1 1 611513.125 465070.25 748346.625 2 1 1 Met-loss+Acetyl [N-Term] cell communication;cell death;cell differentiation;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf01636, Pf07714" 26413 ENSMUSG00000063358.15 Mapk1 16 "NCAM signaling for neurite out-growth; MAP2K and MAPK activation; Spry regulation of FGF signaling; Signal transduction by L1; FCERI mediated MAPK activation; phospho-PLA2 pathway; Regulation of HSF1-mediated heat shock response; Activated TLR4 signalling; Signaling by GPCR; Neutrophil degranulation; Gastrin-CREB signalling pathway via PKC and MAPK; MAPK1 (ERK2) activation; Recycling pathway of L1; Thrombin signalling through proteinase activated receptors (PARs); RHO GTPases Activate WASPs and WAVEs; Golgi Cisternae Pericentriolar Stack Reorganization; Interleukin-20 family signaling; RSK activation; Regulation of actin dynamics for phagocytic cup formation; Activation of the AP-1 family of transcription factors; Growth hormone receptor signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Oncogene Induced Senescence; ERKs are inactivated; Negative feedback regulation of MAPK pathway" Oxytocin signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Acute myeloid leukemia; AGE-RAGE signaling pathway in diabetic complications; mTOR signaling pathway; Cholinergic synapse; Platinum drug resistance; Chagas disease (American trypanosomiasis); T cell receptor signaling pathway; Phospholipase D signaling pathway; Retrograde endocannabinoid signaling; Regulation of actin cytoskeleton; MAPK signaling pathway; Type II diabetes mellitus; Progesterone-mediated oocyte maturation; Ras signaling pathway; Prolactin signaling pathway; TNF signaling pathway; VEGF signaling pathway; Focal adhesion; NOD-like receptor signaling pathway; Insulin signaling pathway; Endometrial cancer; Long-term potentiation; Toxoplasmosis; Chemokine signaling pathway; Breast cancer; Melanoma; Platelet activation; Signaling pathways regulating pluripotency of stem cells; Tuberculosis; Melanogenesis; Hepatitis B; Axon guidance; Oocyte meiosis; Osteoclast differentiation; Non-small cell lung cancer; Adherens junction; Sphingolipid signaling pathway; B cell receptor signaling pathway; Dorso-ventral axis formation; Glutamatergic synapse; Toll-like receptor signaling pathway; Pertussis; Proteoglycans in cancer; Salmonella infection; Fc gamma R-mediated phagocytosis; Thyroid hormone signaling pathway; Neurotrophin signaling pathway; Long-term depression; cGMP-PKG signaling pathway; TGF-beta signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; Pathways in cancer; Influenza A; Hepatitis C; Alzheimer's disease; Alcoholism; Pancreatic cancer; Thyroid cancer; PI3K-Akt signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Renal cell carcinoma; GnRH signaling pathway; Natural killer cell mediated cytotoxicity; Prion diseases; Gap junction; Circadian entrainment; Glioma; Fc epsilon RI signaling pathway; EGFR tyrosine kinase inhibitor resistance; Leishmaniasis; Central carbon metabolism in cancer; Choline metabolism in cancer; Estrogen signaling pathway; Th1 and Th2 cell differentiation; Colorectal cancer; Viral carcinogenesis; Chronic myeloid leukemia; Serotonergic synapse; Adrenergic signaling in cardiomyocytes; Prostate cancer; Endocrine resistance; Bladder cancer; Aldosterone-regulated sodium reabsorption; Apoptosis 0 High A0A075B5Y4 Immunoglobulin heavy variable 1-81 (Fragment) OS=Mus musculus OX=10090 GN=Ighv1-81 PE=4 SV=1 0 8.044 21 2 2 2 117 13 8.79 1 1 1 1 1162698.25 703787.6875 1880541.813 1 1 2 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus protein binding ENSMUSG00000094689.1 12 0 High P70372 ELAV-like protein 1 OS=Mus musculus OX=10090 GN=Elavl1 PE=1 SV=2 0 5.038 7 2 2 2 326 36.1 9.04 1 1 1 1 209738.4844 1301799.375 879668.8125 1 1 1 regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 15568 ENSMUSG00000040028.10 Elavl1 8 mRNA Splicing - Major Pathway; HuR (ELAVL1) binds and stabilizes mRNA AMPK signaling pathway 0 High Q9CQ75 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Mus musculus OX=10090 GN=Ndufa2 PE=1 SV=3 0.006 2.968 22 2 2 2 99 10.9 9.99 1 1 1 1 464459.125 790074.8125 719181.5 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity Pf05047 17991 ENSMUSG00000014294.4 Ndufa2 18 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Medium Q9D2N9 Vacuolar protein sorting-associated protein 33A OS=Mus musculus OX=10090 GN=Vps33a PE=1 SV=2 0.021 2.197 3 1 2 1 598 67.5 7.08 1 1 1 1 164536.0625 452100.9688 543837.5625 1 1 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport endosome;membrane;vacuole protein binding Pf00995 77573 ENSMUSG00000029434.12 Vps33a 5 0 High A8Y5N8 Pleckstrin homology domain-containing family F member 2 (Fragment) OS=Mus musculus OX=10090 GN=Plekhf2 PE=1 SV=1 0 4.891 15 2 2 2 197 22.1 9.45 2 2 247650.6875 409476 692402.4375 1 1 1 transport endoplasmic reticulum;endosome;membrane metal ion binding "Pf00169, Pf01363" 71801 ENSMUSG00000049969.3 Plekhf2 4 0 High Q99P88 Nuclear pore complex protein Nup155 OS=Mus musculus OX=10090 GN=Nup155 PE=1 SV=1 0 4.94 2 1 1 1 1391 155 6.15 1 1 427452.5938 1096779.625 1 1 Met-loss [N-Term] cell organization and biogenesis;transport cytoplasm;membrane;nucleus protein binding;structural molecule activity "Pf03177, Pf08801" 170762 ENSMUSG00000022142.7 Nup155 15 Transcriptional regulation by small RNAs; SUMOylation of RNA binding proteins; snRNP Assembly; SUMOylation of chromatin organization proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins; SUMOylation of DNA replication proteins RNA transport 0 Low E9Q0U7 Heat shock protein 105 kDa OS=Mus musculus OX=10090 GN=Hsph1 PE=1 SV=1 0.102 1.069 1 1 1 1 817 91.6 5.59 1 1 nucleotide binding Pf00012 ENSMUSG00000029657.15 5 0 Medium P58242 Acid sphingomyelinase-like phosphodiesterase 3b OS=Mus musculus OX=10090 GN=Smpdl3b PE=1 SV=1 0.023 1.887 2 1 1 1 456 51.6 6.43 1 1 314203.0313 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane catalytic activity;metal ion binding;protein binding Pf00149 100340 ENSMUSG00000028885.8 Smpdl3b 4 0 Low P48774 Glutathione S-transferase Mu 5 OS=Mus musculus OX=10090 GN=Gstm5 PE=1 SV=1 0.087 1.208 7 1 1 1 224 26.6 7.21 1 1 304362.75 149997.5313 1 1 metabolic process;response to stimulus cytoplasm;nucleus catalytic activity;protein binding "Pf00043, Pf02798, Pf14497" 14866 ENSMUSG00000004032.10 Gstm5 3 Glutathione conjugation Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 Medium Q64012 RNA-binding protein Raly OS=Mus musculus OX=10090 GN=Raly PE=1 SV=3 0.027 1.742 3 1 1 1 312 33.2 8.84 1 1 249660 530031.25 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 19383 ENSMUSG00000027593.15 Raly 2 0 Low Q9JM63 ATP-sensitive inward rectifier potassium channel 10 OS=Mus musculus OX=10090 GN=Kcnj10 PE=1 SV=1 0.059 1.396 3 1 1 1 379 42.4 8.29 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport membrane nucleotide binding;protein binding;transporter activity Pf01007 16513 ENSMUSG00000044708.5 Kcnj10 1 Activation of G protein gated Potassium channels; Potassium transport channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Gastric acid secretion 0 Medium V9GXC1 Peptidyl-prolyl cis-trans isomerase OS=Mus musculus OX=10090 GN=Gm12728 PE=1 SV=1 0.01 2.587 12 1 1 1 77 8.5 5.38 1 1 321193.5625 626690.3125 576091.625 1 1 1 metabolic process catalytic activity Pf00160 ENSMUSG00000083780.8 4 0 Medium P56392 "Cytochrome c oxidase subunit 7A1, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a1 PE=1 SV=1" 0.021 2.223 16 1 1 1 80 9 9.79 1 1 398566.5938 1076713.875 928329.375 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02238 12865 ENSMUSG00000074218.3 Cox7a1 7 Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 Medium Q9CQX8 "28S ribosomal protein S36, mitochondrial OS=Mus musculus OX=10090 GN=Mrps36 PE=1 SV=1" 0.017 2.362 13 1 1 1 102 11.1 9.99 1 1 132078.5938 631106.9375 1 1 mitochondrion;ribosome Pf10937 66128 ENSMUSG00000061474.11 Mrps36 13 Mitochondrial translation termination; Mitochondrial translation elongation 0 Low Q9QWK4 CD5 antigen-like OS=Mus musculus OX=10090 GN=Cd5l PE=1 SV=3 0.069 1.357 3 1 1 1 352 38.8 5.16 1 1 467062.9063 426007.5938 1 1 cell death;defense response;response to stimulus;transport cytoplasm;extracellular;membrane receptor activity "Pf00530, Pf15494" 11801 ENSMUSG00000015854.7 Cd5l 3 0 Medium Q9JHL1 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Mus musculus OX=10090 GN=Slc9a3r2 PE=1 SV=2 0.021 2.206 6 1 1 1 337 37.4 7.59 1 1 394651.125 983531.25 972507.9375 1 1 1 regulation of biological process cytoplasm;membrane;nucleus protein binding;structural molecule activity "Pf00595, Pf09007, Pf13180" 65962 Slc9a3r2 17 Aldosterone-regulated sodium reabsorption 0 Medium Q811W1 Alanine and arginine-rich domain-containing protein OS=Mus musculus OX=10090 GN=Aard PE=2 SV=1 0.04 1.522 4 1 1 1 167 18.9 10.89 1 1 211356.4844 489576.5 616439.5625 1 1 1 239435 ENSMUSG00000068522.4 Aard 15 0 Medium Q8BH00 2-aminomuconic semialdehyde dehydrogenase OS=Mus musculus OX=10090 GN=Aldh8a1 PE=1 SV=1 0.023 2.121 3 1 1 1 487 53.6 7.55 1 1 360103.4063 575105.3125 879655.4375 1 1 1 metabolic process cytoplasm catalytic activity Pf00171 237320 ENSMUSG00000037542.13 Aldh8a1 10 RA biosynthesis pathway 0 Medium Q02053 Ubiquitin-like modifier-activating enzyme 1 OS=Mus musculus OX=10090 GN=Uba1 PE=1 SV=1 0.012 2.463 1 1 1 1 1058 117.7 5.66 1 1 669331.125 1232507.625 1 1 metabolic process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00899, Pf02134, Pf09358, Pf10585" 22201 ENSMUSG00000001924.15 Uba1 X Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes Ubiquitin mediated proteolysis; Parkinson's disease 0 Medium O88796 Ribonuclease P protein subunit p30 OS=Mus musculus OX=10090 GN=Rpp30 PE=1 SV=1 0.023 2.004 6 1 1 1 268 29.5 9.06 1 1 metabolic process nucleus catalytic activity;RNA binding Pf01876 54364 ENSMUSG00000024800.7 Rpp30 19 Ribosome biogenesis in eukaryotes; RNA transport 0 Low Q922M3 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Mus musculus OX=10090 GN=Kctd10 PE=1 SV=1 0.085 1.263 5 1 1 1 315 35.7 6.34 1 1 961491.75 922384.8125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;protein binding "Pf02214, Pf09626" 330171 ENSMUSG00000001098.15 Kctd10 5 0 Medium Q91YI0 Argininosuccinate lyase OS=Mus musculus OX=10090 GN=Asl PE=1 SV=1 0.024 1.851 3 1 1 1 464 51.7 6.96 1 1 435586.2813 1 metabolic process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding "Pf00206, Pf14698" 109900 ENSMUSG00000025533.15 Asl 5 "Metabolic pathways; Biosynthesis of amino acids; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis" 0 High P01791 Ig heavy chain V region HPCM6 OS=Mus musculus OX=10090 PE=1 SV=1 0.002 3.762 13 1 1 1 123 13.9 6.06 1 1 1048823.625 972471.625 1 1 Pf07686 0 Medium E0CXJ2 Seipin OS=Mus musculus OX=10090 GN=Bscl2 PE=1 SV=1 0.021 2.171 4 1 1 1 213 23.6 8.88 1 1 1156519.875 667284.25 2640091.75 1 1 1 membrane Pf06775 ENSMUSG00000071657.12 19 0 Low E9QME1 Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein OS=Mus musculus OX=10090 GN=Bnipl PE=4 SV=1 0.075 1.312 2 1 1 1 356 39.6 5.62 1 1 85566.82813 252408.9219 448231.3125 1 1 1 cell death;regulation of biological process cytosol;nucleus protein binding "Pf00650, Pf12496, Pf13716" 171388 ENSMUSG00000028115.16 Bnipl 3 0 High P28028 Serine/threonine-protein kinase B-raf OS=Mus musculus OX=10090 GN=Braf PE=1 SV=3 0.003 3.544 1 1 1 1 804 88.7 7.65 1 1 865868.4375 1233298.5 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00130, Pf02196, Pf07714, Pf14531" 109880 ENSMUSG00000002413.15 Braf 6 CREB phosphorylation through the activation of Ras; RAF activation; Interleukin-20 family signaling; MAP2K and MAPK activation; Spry regulation of FGF signaling; Negative feedback regulation of MAPK pathway ErbB signaling pathway; FoxO signaling pathway; Acute myeloid leukemia; mTOR signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Progesterone-mediated oocyte maturation; Focal adhesion; Insulin signaling pathway; Endometrial cancer; Long-term potentiation; Chemokine signaling pathway; Breast cancer; Melanoma; Non-small cell lung cancer; Dorso-ventral axis formation; Proteoglycans in cancer; Neurotrophin signaling pathway; Long-term depression; Rap1 signaling pathway; Pathways in cancer; Hepatitis C; Alcoholism; Pancreatic cancer; Thyroid cancer; cAMP signaling pathway; Vascular smooth muscle contraction; Renal cell carcinoma; Natural killer cell mediated cytotoxicity; Glioma; EGFR tyrosine kinase inhibitor resistance; Colorectal cancer; Chronic myeloid leukemia; Serotonergic synapse; Prostate cancer; Endocrine resistance; Bladder cancer 0 High P54728 UV excision repair protein RAD23 homolog B OS=Mus musculus OX=10090 GN=Rad23b PE=1 SV=2 0 7.754 5 1 1 1 416 43.5 4.83 1 1 1430802.25 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus;proteasome DNA binding;protein binding "Pf00240, Pf00627, Pf09280, Pf11976, Pf13881" 19359 ENSMUSG00000028426.10 Rad23b 4 N-glycan trimming in the ER and Calnexin/Calreticulin cycle; DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER Nucleotide excision repair; Protein processing in endoplasmic reticulum 0 High Q9Z0R6 Intersectin-2 OS=Mus musculus OX=10090 GN=Itsn2 PE=1 SV=2 0.003 3.22 1 1 1 1 1659 188.8 8.13 1 1 366655.25 769030.8125 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00018, Pf00168, Pf00169, Pf00621, Pf01025, Pf02463, Pf03961, Pf03962, Pf04111, Pf04156, Pf05483, Pf06156, Pf06160, Pf06818, Pf07653, Pf07888, Pf07926, Pf09731, Pf10174, Pf10186, Pf12763, Pf13514, Pf14604" 20403 Itsn2 12 0 Medium Q9D172 "Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial OS=Mus musculus OX=10090 GN=Gatd3a PE=1 SV=1" 0.023 2.023 6 1 1 1 266 28.1 8.78 1 1 513878.8438 1033661.5 1 1 mitochondrion Pf01965 28295; 102641949 ENSMUSG00000053329.7 D10Jhu81e; LOC100046684; LOC102641949 10 0 Medium P98203 Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog OS=Mus musculus OX=10090 GN=Arvcf PE=1 SV=2 0.023 1.877 2 1 1 1 962 105 6.64 1 1 246918.3594 1 development cytoplasm;membrane;nucleus protein binding "Pf00514, Pf04826, Pf13646" 11877 ENSMUSG00000000325.15; ENSMUSG00000098615.3 Arvcf 16; CHR_MG3833_MG4220_PATCH 0 Low P07758 Alpha-1-antitrypsin 1-1 OS=Mus musculus OX=10090 GN=Serpina1a PE=1 SV=4 0.059 1.397 2 1 1 1 413 46 5.72 1 1 1033666.438 1 defense response;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;Golgi enzyme regulator activity;protein binding Pf00079 20700; 20703 ENSMUSG00000066366.14 Serpina1a; Serpina1d 12 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Cargo concentration in the ER; Post-translational protein phosphorylation; COPII (Coat Protein 2) Mediated Vesicle Transport; Neutrophil degranulation; Platelet degranulation Complement and coagulation cascades 0 Low A0A3B2WCC1 Protein MEMO1 (Fragment) OS=Mus musculus OX=10090 GN=Memo1 PE=1 SV=1 0.082 1.274 7 1 1 1 107 11.8 9.1 1 1 105846.7266 178649.6406 1 1 0 Medium P24369 Peptidyl-prolyl cis-trans isomerase B OS=Mus musculus OX=10090 GN=Ppib PE=1 SV=2 0.018 2.269 5 1 1 1 216 23.7 9.55 1 1 173586.9531 649606.6875 704693.5 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 19035 ENSMUSG00000032383.7 Ppib 9 Collagen biosynthesis and modifying enzymes 0 Medium D6RHN4 Peroxisomal trans-2-enoyl-CoA reductase OS=Mus musculus OX=10090 GN=Pecr PE=1 SV=1 0.023 1.884 10 1 1 1 90 9.4 8.53 1 1 78946.47656 545556.875 1141603.625 1 1 1 ENSMUSG00000026189.13 1 0 Low E9Q9G4 Protein FAM214B OS=Mus musculus OX=10090 GN=Fam214b PE=1 SV=1 0.085 1.263 6 1 1 1 332 34.2 6.83 1 1 469823.4063 368426.0938 604360.8125 1 1 1 ENSMUSG00000036002.12 4 0 Medium Q8CCF0 U4/U6 small nuclear ribonucleoprotein Prp31 OS=Mus musculus OX=10090 GN=Prpf31 PE=1 SV=3 0.023 2.005 4 1 1 1 499 55.4 5.67 1 1 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex RNA binding "Pf01798, Pf08060, Pf09785" 68988 ENSMUSG00000008373.16 Prpf31 7 mRNA Splicing - Major Pathway Spliceosome 0 High A0A0N4SVX7 Protease-associated domain-containing protein 1 OS=Mus musculus OX=10090 GN=Pradc1 PE=1 SV=1 0.003 3.402 20 1 1 1 61 7 5.83 1 1 ENSMUSG00000030008.9 6 0 Medium A2AI69 cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Mus musculus OX=10090 GN=Prkar1a PE=1 SV=1 0.035 1.568 5 1 1 1 171 19.4 6.07 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process cytoplasm;membrane enzyme regulator activity;nucleotide binding;protein binding "Pf02197, Pf02309" 19084 ENSMUSG00000020612.16 Prkar1a 11 0 High Q6KAR6 Exocyst complex component 3 OS=Mus musculus OX=10090 GN=Exoc3 PE=1 SV=2 0.004 3.014 2 1 1 1 755 86.4 6.2 1 1 transport cytoplasm;Golgi;membrane protein binding Pf06046 211446 ENSMUSG00000034152.5 Exoc3 13 Insulin processing; VxPx cargo-targeting to cilium Tight junction 0 High Q9R0Y5 Adenylate kinase isoenzyme 1 OS=Mus musculus OX=10090 GN=Ak1 PE=1 SV=1 0.01 2.796 6 1 1 1 194 21.5 5.81 1 1 360526.875 702973.3125 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding "Pf00406, Pf13207, Pf13238, Pf13671" 11636 ENSMUSG00000026817.14 Ak1 2 Interconversion of nucleotide di- and triphosphates Thiamine metabolism; Metabolic pathways; Purine metabolism 0 Medium Q8C3K6 Sodium/glucose cotransporter 1 OS=Mus musculus OX=10090 GN=Slc5a1 PE=1 SV=1 0.018 2.276 1 1 1 1 665 73.4 6.98 1 1 447903.9063 1 transport membrane transporter activity Pf00474 20537 Slc5a1 5 Carbohydrate digestion and absorption; Mineral absorption; Bile secretion 0 Low Q6PGF5 "BMS1 homolog, ribosome assembly protein (Yeast) OS=Mus musculus OX=10090 GN=Bms1 PE=1 SV=1" 0.082 1.281 1 1 1 1 1284 145.3 6.27 1 1 1987565.875 2501090.25 1 1 metabolic process nucleus catalytic activity;nucleotide binding;RNA binding "Pf04950, Pf08142" 213895 ENSMUSG00000030138.8 Bms1 6 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High Q3UJU9 Regulator of microtubule dynamics protein 3 OS=Mus musculus OX=10090 GN=Rmdn3 PE=1 SV=2 0.003 3.694 3 1 1 1 470 52 5.21 1 1 cell death;cell differentiation;cellular homeostasis cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus protein binding 67809 ENSMUSG00000070730.11 Fam82a2; Rmdn3 2 0 High Q6ZWX6 Eukaryotic translation initiation factor 2 subunit 1 OS=Mus musculus OX=10090 GN=Eif2s1 PE=1 SV=3 0.009 2.901 4 1 1 1 315 36.1 5.08 1 1 373226 760299.9375 1602706.125 1 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding "Pf00575, Pf07541" 13665 ENSMUSG00000021116.10 Eif2s1 12 "L13a-mediated translational silencing of Ceruloplasmin expression; PERK regulates gene expression; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Herpes simplex infection; Non-alcoholic fatty liver disease (NAFLD); Influenza A; Hepatitis C; RNA transport; Protein processing in endoplasmic reticulum; Measles; Apoptosis 0 Medium Q91ZJ5 UTP--glucose-1-phosphate uridylyltransferase OS=Mus musculus OX=10090 GN=Ugp2 PE=1 SV=3 0.029 1.651 2 1 1 1 508 56.9 7.61 1 1 117609.0625 273881.9063 337841.0313 1 1 1 metabolic process cytoplasm;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf01704 216558 ENSMUSG00000001891.16 Ugp2 11 "Formation of the active cofactor, UDP-glucuronate; Glycogen synthesis" Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Starch and sucrose metabolism; Pentose and glucuronate interconversions; Galactose metabolism 0 Low Q7TN79 A-kinase anchor protein 7 isoform gamma OS=Mus musculus OX=10090 GN=Akap7 PE=1 SV=2 0.104 1.063 6 1 1 1 314 35.5 7.87 1 1 3856428.75 4148811.5 4966201 1 1 1 regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus nucleotide binding;protein binding;structural molecule activity "Pf05213, Pf10469, Pf10470" 432442 ENSMUSG00000039166.16 Akap7 10 0 Medium A0A0R4J0J8 Cytospin-A OS=Mus musculus OX=10090 GN=Specc1l PE=1 SV=1 0.036 1.557 1 1 1 1 1135 126.5 5.94 1 1 786184.125 842801.875 1 1 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00307, Pf01576, Pf01920, Pf02463, Pf02932, Pf03251, Pf04111, Pf04156, Pf05667, Pf05701, Pf08317, Pf10186, Pf11971, Pf12128, Pf13166" 74392 ENSMUSG00000033444.14 Specc1l 10 0 Low Q8BJL1 F-box only protein 30 OS=Mus musculus OX=10090 GN=Fbxo30 PE=1 SV=2 0.082 1.279 1 1 1 1 746 82.6 5.26 1 1 560177.125 592265.5625 1 1 metabolic process catalytic activity;metal ion binding;protein binding "Pf00646, Pf12937" 71865 ENSMUSG00000047648.13 Fbxo30 10 Neddylation; Antigen processing: Ubiquitination & Proteasome degradation 0 Medium A3KGE7 Collagen alpha-1(V) chain (Fragment) OS=Mus musculus OX=10090 GN=Col5a1 PE=1 SV=1 0.023 1.904 3 1 1 1 349 37.8 4.87 1 1 306985.75 1286882.25 827540.0625 1 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process extracellular protein binding;structural molecule activity "Pf01391, Pf01410" 12831 ENSMUSG00000026837.15 Col5a1 2 0 High E0CXZ0 Nucleolar protein 56 OS=Mus musculus OX=10090 GN=Nop56 PE=1 SV=1 0.002 4.266 10 1 1 1 261 29.1 7.18 1 1 "Pf08060, Pf08156" ENSMUSG00000027405.16 2 0 Low Q8VC16 Leucine-rich repeat-containing protein 14 OS=Mus musculus OX=10090 GN=Lrrc14 PE=1 SV=1 0.096 1.14 1 1 1 1 493 54.9 6.67 1 1 2318165.25 3484955.75 4589742 1 1 1 regulation of biological process cytoplasm protein binding 223664 ENSMUSG00000033728.14 Lrrc14 15 0 Medium F7AX23 Syntaxin-binding protein 4 (Fragment) OS=Mus musculus OX=10090 GN=Stxbp4 PE=1 SV=1 0.041 1.511 6 1 1 1 154 17.4 5.26 1 1 regulation of biological process;response to stimulus;transport protein binding Pf00397 ENSMUSG00000020546.14 11 0 High Q9D7S9 Charged multivesicular body protein 5 OS=Mus musculus OX=10090 GN=Chmp5 PE=1 SV=1 0 5.661 12 1 1 1 219 24.6 4.79 1 1 56363.02734 89438.5625 343358.9063 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane;nucleus protein binding Pf03357 76959 ENSMUSG00000028419.5 Chmp5 4 Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 High Q61074 Protein phosphatase 1G OS=Mus musculus OX=10090 GN=Ppm1g PE=1 SV=3 0.003 3.583 2 1 1 1 542 58.7 4.39 1 1 754611.9375 2064219.875 1 1 metabolic process;regulation of biological process membrane;nucleus catalytic activity;metal ion binding;protein binding Pf00481 14208 ENSMUSG00000029147.10 Ppm1g 5 0 Medium P97384 Annexin A11 OS=Mus musculus OX=10090 GN=Anxa11 PE=1 SV=2 0.01 2.597 2 1 1 1 503 54 7.66 1 1 269367.4688 424652.7813 683465.875 1 1 1 cell division;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;vacuole metal ion binding;protein binding;RNA binding Pf00191 11744 ENSMUSG00000021866.15 Anxa11 14 0 Medium Q91VX9 Transmembrane protein 168 OS=Mus musculus OX=10090 GN=Tmem168 PE=1 SV=1 0.027 1.718 2 1 1 1 697 79.6 7.96 1 1 239316.3594 268925.3438 701165.6875 1 1 1 membrane 101118 ENSMUSG00000029569.9 Tmem168 6 0 Medium A2AIL4 "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Mus musculus OX=10090 GN=Ndufaf6 PE=1 SV=1" 0.023 2.066 5 1 1 1 333 38.3 9.44 1 1 653365.4375 1 cell organization and biogenesis;metabolic process cytoplasm;membrane;mitochondrion;nucleus catalytic activity Pf00494 76947 ENSMUSG00000050323.14 Ndufaf6 4 Complex I biogenesis 0 High A0A075B5Q3 Immunoglobulin heavy variable 2-5 OS=Mus musculus OX=10090 GN=Ighv2-5 PE=4 SV=1 0.009 2.878 11 1 1 1 115 12.5 8.97 1 1 419693.7188 237652 1948609.25 1 1 1 ENSMUSG00000096498.3 12 0 Medium G3UY93 Valyl-tRNA synthetase (Fragment) OS=Mus musculus OX=10090 GN=Vars PE=1 SV=1 0.033 1.641 3 1 1 1 1278 141.3 7.75 1 1 metabolic process;regulation of biological process cytoplasm catalytic activity;nucleotide binding "Pf00043, Pf00133, Pf08264, Pf09334, Pf13603" ENSMUSG00000007029.16 17 0 Low Q3UXG7 GDP-fucose protein O-fucosyltransferase 1 OS=Mus musculus OX=10090 GN=Pofut1 PE=1 SV=1 0.088 1.22 3 1 1 1 353 40 8.48 1 1 274223.4063 808550 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf10250 140484 ENSMUSG00000046020.13 Pofut1 2 0 High P49586 Choline-phosphate cytidylyltransferase A OS=Mus musculus OX=10090 GN=Pcyt1a PE=1 SV=1 0.004 3.079 4 1 1 1 367 41.6 7.03 1 1 721971.375 948638.4375 1 1 metabolic process cytoplasm;cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding Pf01467 13026 ENSMUSG00000005615.14 Pcyt1a 16 Synthesis of PC Metabolic pathways; Glycerophospholipid metabolism; Choline metabolism in cancer 0 Medium A0A087WSL8 Nucleolar protein 58 (Fragment) OS=Mus musculus OX=10090 GN=Nop58 PE=1 SV=1 0.01 2.696 10 1 1 1 191 21.8 5.15 1 1 237154.5625 1 "Pf01798, Pf08060" ENSMUSG00000026020.9 1 0 High Q9WVD5 Mitochondrial ornithine transporter 1 OS=Mus musculus OX=10090 GN=Slc25a15 PE=1 SV=1 0.003 3.248 4 1 1 1 301 32.8 8.85 1 1 transport membrane;mitochondrion transporter activity Pf00153 18408 ENSMUSG00000031482.9 Slc25a15 8 0 High Q8BYF6 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus OX=10090 GN=Slc5a8 PE=1 SV=1 0.01 2.774 3 1 1 1 611 66.7 8.22 1 1 181706.2188 504355.8438 1 1 cell death;transport membrane transporter activity Pf00474 216225 ENSMUSG00000020062.7 Slc5a8 10 Organic anion transporters; Nicotinamide salvaging 0 Medium Q99P21 Adenine DNA glycosylase OS=Mus musculus OX=10090 GN=Mutyh PE=1 SV=2 0.036 1.557 2 1 1 1 515 57.7 9.41 1 1 640383.125 1386591.125 1705116.375 1 1 1 metabolic process;response to stimulus mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00293, Pf00633, Pf00730, Pf10576, Pf14815" 70603 ENSMUSG00000028687.17 Mutyh 4 Displacement of DNA glycosylase by APEX1; Cleavage of the damaged purine Base excision repair 0 Medium Q9CZW5 Mitochondrial import receptor subunit TOM70 OS=Mus musculus OX=10090 GN=Tomm70 PE=1 SV=2 0.023 1.98 2 1 1 1 611 67.5 7.53 1 1 446566.5938 849096.625 1 1 membrane;mitochondrion protein binding "Pf00515, Pf07719, Pf13414" 28185 ENSMUSG00000022752.8 Tomm70a 16 Pink/Parkin Mediated Mitophagy 0 High A0A0U1RQB4 Electron transfer flavoprotein subunit beta (Fragment) OS=Mus musculus OX=10090 GN=Etfb PE=1 SV=1 0.009 2.948 10 1 1 1 100 10.8 8.09 1 1 308788.4063 747059 555774 1 1 1 metabolic process mitochondrion Pf01012 ENSMUSG00000004610.4 7 0 High Q99LB7 "Sarcosine dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Sardh PE=1 SV=1" 0.003 3.25 2 1 1 1 919 101.6 6.74 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf01266, Pf01571, Pf08669" 192166 ENSMUSG00000009614.16 Sardh 2 Choline catabolism "Metabolic pathways; Glycine, serine and threonine metabolism" 0 Medium Q8R1I1 Cytochrome b-c1 complex subunit 9 OS=Mus musculus OX=10090 GN=Uqcr10 PE=1 SV=1 0.017 2.303 27 1 1 1 64 7.4 9.19 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf05365 66152 ENSMUSG00000059534.8 Uqcr10 11 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P46460 Vesicle-fusing ATPase OS=Mus musculus OX=10090 GN=Nsf PE=1 SV=2 0.002 4.174 2 1 1 1 744 82.6 6.95 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf02359, Pf02933, Pf05272, Pf05496, Pf06068, Pf07724, Pf07728, Pf13173, Pf13191, Pf13207, Pf13401" 18195 ENSMUSG00000034187.18 Nsf 11 Trafficking of GluR2-containing AMPA receptors; Intra-Golgi traffic; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; Retrograde transport at the Trans-Golgi-Network GABAergic synapse; Vasopressin-regulated water reabsorption; Synaptic vesicle cycle 0 Low Q91YX0 Protein THEMIS2 OS=Mus musculus OX=10090 GN=Themis2 PE=1 SV=2 0.082 1.281 2 1 1 1 663 74.3 6.19 1 1 1335973.875 1048452.688 1728883.25 1 1 1 defense response;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding Pf12736 230787 ENSMUSG00000037731.5 Themis2 4 0 Medium G3X972 "Sec24-related gene family, member C (S. cerevisiae) OS=Mus musculus OX=10090 GN=Sec24c PE=1 SV=1" 0.023 1.997 2 1 1 1 1096 118.5 6.84 1 1 cell organization and biogenesis;transport cytoplasm;cytosol;membrane metal ion binding;protein binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033, Pf09770" 218811 ENSMUSG00000039367.9 Sec24c 14 "Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" 0 Medium A0A0A6YY50 Cytochrome P450 4B1 (Fragment) OS=Mus musculus OX=10090 GN=Cyp4b1 PE=1 SV=1 0.049 1.439 6 1 1 1 208 24.1 6.96 1 1 752251.3125 982119.5 1 1 metabolic process catalytic activity;metal ion binding Pf00067 ENSMUSG00000028713.17 4 0 High A3KGR9 Histocompatibility 13 (Fragment) OS=Mus musculus OX=10090 GN=H13 PE=1 SV=1 0.01 2.754 3 1 1 1 347 38.2 8.4 1 1 1128106 1521740.375 1523838.25 1 1 1 metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity;protein binding Pf04258 14950 ENSMUSG00000019188.16 H13 2 0 Medium Q3UHK8 Trinucleotide repeat-containing gene 6A protein OS=Mus musculus OX=10090 GN=Tnrc6a PE=1 SV=2 0.029 1.652 1 1 1 1 1896 203 6.99 1 1 475814.5313 2028697.125 1509327.5 1 1 1 0 High A0A1W2P7X0 Costars family protein ABRACL (Fragment) OS=Mus musculus OX=10090 GN=Abracl PE=1 SV=1 0.003 3.569 28 1 1 1 57 6.4 8.92 1 1 1003906.438 1 Acetyl [N-Term] Pf14705 ENSMUSG00000078453.3 10 0 Medium Q3TB82 Pleckstrin homology domain-containing family F member 1 OS=Mus musculus OX=10090 GN=Plekhf1 PE=2 SV=1 0.023 1.892 4 1 1 1 279 31.1 8.1 1 1 184424.9531 872302.0625 1781381 1 1 1 cell death;cell organization and biogenesis;regulation of biological process cytoplasm;endosome;mitochondrion;nucleus;vacuole metal ion binding "Pf00169, Pf01363" 72287 ENSMUSG00000074170.5 Plekhf1 7 0 Medium E9QAF9 Protein TANC1 OS=Mus musculus OX=10090 GN=Tanc1 PE=1 SV=1 0.035 1.564 1 1 1 1 1849 199.9 8.32 1 1 cell organization and biogenesis;response to stimulus membrane protein binding "Pf00023, Pf12796, Pf13414, Pf13424, Pf13432, Pf13606, Pf13637, Pf13857" 66860 ENSMUSG00000035168.16 Tanc1 2 0 Low P01807 Ig heavy chain V region X44 OS=Mus musculus OX=10090 PE=1 SV=1 0.055 1.407 13 1 1 1 119 13.2 7.94 1 1 316077.6563 1562650.875 1 1 Pf07686 0 Medium A0A087WQS2 Basic leucine zipper and W2 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Bzw1 PE=1 SV=1 0.046 1.457 2 1 1 1 451 51.2 6.95 1 1 881515.25 9099695 17639622 1 1 1 metabolic process;regulation of biological process cytoplasm;membrane protein binding;RNA binding Pf02020 66882 ENSMUSG00000051223.14 Bzw1 1 0 High P01635 Ig kappa chain V-V region K2 (Fragment) OS=Mus musculus OX=10090 PE=1 SV=1 0.004 3.057 9 1 1 1 115 12.6 8.31 1 1 593431.1875 853541 1 1 "Pf00047, Pf07679, Pf07686, Pf13927" 619960 ENSMUSG00000095007.1 Igkv12-41 6 0 High Q9QUI0 Transforming protein RhoA OS=Mus musculus OX=10090 GN=Rhoa PE=1 SV=1 0.002 4.3 6 1 1 1 193 21.8 6.1 1 1 1421465 1 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endosome;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf08477" 11848 ENSMUSG00000007815.13 Rhoa 9 "RHO GTPases activate KTN1; PCP/CE pathway; Ovarian tumor domain proteases; ERBB2 Regulates Cell Motility; G beta:gamma signalling through PI3Kgamma; RHO GTPases Activate Rhotekin and Rhophilins; Sema4D induced cell migration and growth-cone collapse; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Rho GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; GPVI-mediated activation cascade; EPHB-mediated forward signaling; EPHA-mediated growth cone collapse; RHO GTPases activate PKNs; SLIT2:ROBO1 increases RHOA activity; VEGFA-VEGFR2 Pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); RHO GTPases activate CIT; Neutrophil degranulation; Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases Activate ROCKs; RHO GTPases Activate Formins; G alpha (12/13) signalling events; PI3K/AKT activation" Oxytocin signaling pathway; Leukocyte transendothelial migration; Endocytosis; mTOR signaling pathway; Wnt signaling pathway; T cell receptor signaling pathway; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; Pancreatic secretion; MicroRNAs in cancer; Ras signaling pathway; Focal adhesion; NOD-like receptor signaling pathway; Chemokine signaling pathway; Platelet activation; Tuberculosis; Axon guidance; Adherens junction; Sphingolipid signaling pathway; Pertussis; Proteoglycans in cancer; Neurotrophin signaling pathway; cGMP-PKG signaling pathway; TGF-beta signaling pathway; Rap1 signaling pathway; Pathways in cancer; cAMP signaling pathway; Vascular smooth muscle contraction; Tight junction; Colorectal cancer; Viral carcinogenesis; Bacterial invasion of epithelial cells 0 Medium Q8BI46 Arginine/serine-rich coiled-coil protein 2 OS=Mus musculus OX=10090 GN=Rsrc2 PE=1 SV=1 0.023 1.95 6 1 1 1 189 23.2 12.18 1 1 208606 ENSMUSG00000029422.14 Rsrc2 5 0 Low D3YZN4 Paraplegin OS=Mus musculus OX=10090 GN=Spg7 PE=1 SV=1 0.07 1.346 2 1 1 1 676 75 7.4 1 1 3299302.25 1 metabolic process;response to stimulus membrane catalytic activity;metal ion binding;nucleotide binding "Pf00004, Pf01078, Pf01434, Pf05496, Pf06068, Pf07724, Pf07728" ENSMUSG00000000738.18 8 0 High A0A0A6YX73 cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Mus musculus OX=10090 GN=Prkar2a PE=1 SV=1 0.009 2.89 6 1 1 1 380 43.1 4.93 1 1 Met-loss+Acetyl [N-Term] regulation of biological process enzyme regulator activity;nucleotide binding "Pf00027, Pf02197" ENSMUSG00000032601.13 9 PKA activation; Signaling by GPCR; PKA activation in glucagon signalling; DARPP-32 events; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production 0 Medium Q8VC60 Beta-galactosidase-1-like protein OS=Mus musculus OX=10090 GN=Glb1l PE=1 SV=1 0.012 2.458 1 1 1 1 646 73.2 7.28 1 1 366361.8438 420169.2813 1 1 metabolic process extracellular;vacuole catalytic activity "Pf01301, Pf02449, Pf13364" 74577 ENSMUSG00000026200.13 Glb1l 1 0 Medium P56382 "ATP synthase subunit epsilon, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1e PE=1 SV=2" 0.033 1.643 13 1 1 1 52 5.8 10.01 1 1 432645.7188 420110.125 2423594 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf04627 67126 ENSMUSG00000016252.7 Atp5e 2 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Medium A0A0R4J0B4 N-acylneuraminate cytidylyltransferase OS=Mus musculus OX=10090 GN=Cmas PE=1 SV=1 0.021 2.167 4 1 1 1 432 48 8.1 1 1 248021.4063 668845.625 1202030.625 1 1 1 metabolic process membrane;nucleus catalytic activity "Pf02348, Pf12804" 12764 ENSMUSG00000030282.14 Cmas 6 Sialic acid metabolism Metabolic pathways; Amino sugar and nucleotide sugar metabolism 0 High Q922Q1 Mitochondrial amidoxime reducing component 2 OS=Mus musculus OX=10090 GN=Mtarc2 PE=1 SV=1 0.002 3.944 4 1 1 1 338 38.2 8.68 1 1 1026916.313 1561400.625 1 1 metabolic process membrane;mitochondrion catalytic activity;metal ion binding "Pf03473, Pf03476" 67247 ENSMUSG00000073481.9 Marc2; Mosc2 1 Phase I - Functionalization of compounds 0 High H3BJ12 Golgi phosphoprotein 3-like (Fragment) OS=Mus musculus OX=10090 GN=Golph3l PE=1 SV=1 0.002 4.144 5 1 1 1 278 31.9 7.27 1 1 148566.4531 420717.125 1 1 transport "Pf02350, Pf05719" ENSMUSG00000046519.15 3 0 Low A0A0A6YW53 Mitogen-activated protein kinase kinase kinase kinase 4 OS=Mus musculus OX=10090 GN=Map4k4 PE=1 SV=1 0.085 1.261 1 1 1 1 1288 146.6 7.49 1 1 333420.8125 747782.4375 605541.625 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00780, Pf07714" 26921 ENSMUSG00000026074.14 Map4k4 1 0 Medium E9Q1G8 Septin-7 OS=Mus musculus OX=10090 GN=Septin7 PE=1 SV=2 0.023 1.941 2 1 1 1 437 50.6 8.57 1 1 111695.5938 520570.0313 678225.3125 1 1 1 cell differentiation;cell division;cell growth;cell organization and biogenesis;regulation of biological process chromosome;cytoplasm;cytoskeleton;membrane;nucleus nucleotide binding;protein binding "Pf00735, Pf01926, Pf05368" 235072 ENSMUSG00000001833.17 Sept7 9 MAPK6/MAPK4 signaling 0 Medium A0A087WP87 E3 ubiquitin-protein ligase RING2 (Fragment) OS=Mus musculus OX=10090 GN=Rnf2 PE=1 SV=1 0.027 1.725 3 1 1 1 211 23.2 8.16 1 1 1012847.688 1 ENSMUSG00000026484.13 1 0 Medium E9QB02 "Methionine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Mars1 PE=1 SV=1" 0.01 2.622 1 1 1 1 910 102.3 6.92 1 1 589604.9375 613751.375 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00043, Pf00133, Pf00458, Pf09334, Pf13410, Pf14497" 216443 ENSMUSG00000040354.14 Mars 10 0 Medium Q9CQQ8 U6 snRNA-associated Sm-like protein LSm7 OS=Mus musculus OX=10090 GN=Lsm7 PE=1 SV=1 0.027 1.71 24 1 1 1 103 11.6 5.27 1 1 48457.59766 342244.625 1 1 metabolic process cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 66094 ENSMUSG00000035215.9 Lsm7 10 mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease RNA degradation; Spliceosome 0 Low P84096 Rho-related GTP-binding protein RhoG OS=Mus musculus OX=10090 GN=Rhog PE=1 SV=1 0.06 1.394 10 1 1 1 191 21.3 8.12 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf04670, Pf08477" 56212 ENSMUSG00000073982.11 Rhog 7 RHO GTPases activate KTN1; Rho GTPase cycle; G alpha (12/13) signalling events; GPVI-mediated activation cascade; Neutrophil degranulation; Sema4D induced cell migration and growth-cone collapse Salmonella infection; Bacterial invasion of epithelial cells 0 Low E9Q3P4 Centromere protein F OS=Mus musculus OX=10090 GN=Cenpf PE=1 SV=1 0.082 1.284 0 1 1 1 2997 342.3 5.16 1 1 3487246.25 2129846 2183589 1 1 1 metabolic process;regulation of biological process;transport chromosome;cytoplasm;nucleus catalytic activity;motor activity;protein binding;transporter activity "Pf01496, Pf01576, Pf02463, Pf04111, Pf05557, Pf10473, Pf10481, Pf10490, Pf12128, Pf13166" 108000 ENSMUSG00000026605.14 Cenpf 1 Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; RHO GTPases Activate Formins 0 Low E9Q1M1 PDZ domain-containing 2 OS=Mus musculus OX=10090 GN=Pdzd2 PE=1 SV=1 0.098 1.082 1 1 1 1 2796 296.5 7.65 1 1 cytoplasm;endoplasmic reticulum;extracellular;nucleus protein binding "Pf00595, Pf13180" 68070 ENSMUSG00000022197.15 Pdzd2 15 0 Medium Q9D5T0 ATPase family AAA domain-containing protein 1 OS=Mus musculus OX=10090 GN=Atad1 PE=1 SV=1 0.021 2.208 2 1 1 1 361 40.7 6.9 1 1 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf06068, Pf07724, Pf07726, Pf13173, Pf13191, Pf13207, Pf13479" 67979 ENSMUSG00000013662.5 Atad1 19 0 High Q9D880 Mitochondrial import inner membrane translocase subunit TIM50 OS=Mus musculus OX=10090 GN=Timm50 PE=1 SV=1 0.002 4.328 3 1 1 1 353 39.8 8.13 1 1 265383.3125 1210851.75 2327730.5 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;protein binding Pf03031 66525 ENSMUSG00000003438.17 Timm50 7 0 High Q9CQR2 40S ribosomal protein S21 OS=Mus musculus OX=10090 GN=Rps21 PE=1 SV=1 0.003 3.392 12 1 1 1 83 9.1 8.51 1 1 153416.1094 639565.875 1482896.875 1 1 1 metabolic process ribosome protein binding;RNA binding;structural molecule activity Pf01249 66481 ENSMUSG00000039001.12 Rps21 2 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 Low D6RDT5 Solute carrier family 25 member 39 OS=Mus musculus OX=10090 GN=Slc25a39 PE=1 SV=1 0.091 1.18 26 1 1 1 136 14.8 6.99 1 1 membrane;mitochondrion Pf00153 ENSMUSG00000018677.9 11 0 Medium O55125 Protein NipSnap homolog 1 OS=Mus musculus OX=10090 GN=Nipsnap1 PE=1 SV=1 0.017 2.298 3 1 1 1 284 33.3 9.44 1 1 380448.6875 313780.2188 471829.9688 1 1 1 membrane;mitochondrion protein binding Pf07978 18082 ENSMUSG00000034285.15 Nipsnap1 11 0 Low Q5SW87 "RAB1A, member RAS oncogene family OS=Mus musculus OX=10090 GN=Rab1a PE=1 SV=1" 0.06 1.389 4 1 1 1 138 15 8.13 1 1 171965.7031 211882.5156 1 1 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;nucleotide binding;protein binding "Pf00071, Pf07728, Pf13191, Pf13401" 19324 ENSMUSG00000020149.17 Rab1; Rab1a 11 0 High Q9D554 Splicing factor 3A subunit 3 OS=Mus musculus OX=10090 GN=Sf3a3 PE=1 SV=2 0 6.499 3 1 1 1 501 58.8 5.34 1 1 318619.4688 422322.3438 1 1 metabolic process nucleus;spliceosomal complex metal ion binding;RNA binding "Pf11931, Pf12108, Pf13297" 75062 ENSMUSG00000028902.4 Sf3a3 4 mRNA Splicing - Major Pathway Spliceosome 0 Medium Q9Z307 Inward rectifier potassium channel 16 OS=Mus musculus OX=10090 GN=Kcnj16 PE=1 SV=2 0.028 1.698 2 1 1 1 419 48 7.83 1 1 499880.6875 1200492.75 1 1 regulation of biological process;transport membrane transporter activity "Pf00520, Pf01007" 16517 ENSMUSG00000051497.15 Kcnj16 11 Activation of G protein gated Potassium channels; Potassium transport channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Gastric acid secretion 0 Medium O35492 Dual specificity protein kinase CLK3 OS=Mus musculus OX=10090 GN=Clk3 PE=1 SV=2 0.017 2.31 3 1 1 1 638 73.8 9.94 1 1 657743.3125 1 metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf07714" 102414 ENSMUSG00000032316.8 Clk3 9 0 Low P13745 Glutathione S-transferase A1 OS=Mus musculus OX=10090 GN=Gsta1 PE=1 SV=2 0.06 1.394 4 1 1 1 223 25.6 8.98 1 1 430227.6563 196498.2813 435364 1 1 1 metabolic process;response to stimulus cytosol catalytic activity;protein binding "Pf00043, Pf02798, Pf13336, Pf13409, Pf13417" 14857 ENSMUSG00000074183.3 Gsta1 9 Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 Low Q7TMY4 THO complex subunit 7 homolog OS=Mus musculus OX=10090 GN=Thoc7 PE=1 SV=2 0.062 1.371 3 1 1 1 204 23.7 5.67 1 1 1295144.25 1 metabolic process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding Pf05615 66231 ENSMUSG00000053453.8 Thoc7 14 mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript RNA transport 0 Medium E9Q3M3 Dynactin subunit 1 OS=Mus musculus OX=10090 GN=Dctn1 PE=1 SV=1 0.01 2.738 1 1 1 1 1264 139.7 5.71 1 1 91597.53906 506926.2188 636419.5 1 1 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;protein binding "Pf01302, Pf05622, Pf05667, Pf06160, Pf12128, Pf12455, Pf15035" 13191 ENSMUSG00000031865.16 Dctn1 6 0 High P08030 Adenine phosphoribosyltransferase OS=Mus musculus OX=10090 GN=Aprt PE=1 SV=2 0 8.661 14 1 1 1 180 19.7 6.79 1 1 202527.6719 3168078.25 1423252.75 1 1 1 metabolic process;response to stimulus;transport cytoplasm;cytosol catalytic activity;nucleotide binding Pf00156 11821 ENSMUSG00000006589.8 Aprt 8 Neutrophil degranulation; Purine salvage Metabolic pathways; Purine metabolism 0 Low A2AKX3 Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 0.097 1.119 0 1 1 1 2646 297.4 6.83 1 1 175691.0156 587897.4375 1046575.625 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00580, Pf12726, Pf13086, Pf13087, Pf13245, Pf13401, Pf13604" 269254 ENSMUSG00000043535.13 Setx 2 0 High A0A075B5M7 Immunoglobulin kappa variable 5-39 OS=Mus musculus OX=10090 GN=Igkv5-39 PE=1 SV=7 0.002 3.822 19 1 1 1 95 10.3 6.25 1 1 5216721.5 1 "Pf00047, Pf07679, Pf07686" ENSMUSG00000076569.3 6 0 Low Q6P572 Mtmr2 protein OS=Mus musculus OX=10090 GN=Mtmr2 PE=1 SV=1 0.092 1.162 2 1 1 1 571 65.7 7.88 1 1 105366.9219 297880.9688 517449.6563 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;endosome;membrane;nucleus catalytic activity;protein binding "Pf02893, Pf06602" 77116 ENSMUSG00000031918.16 Mtmr2 9 Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system 0 High Q6NZD2 Sorting nexin-1 OS=Mus musculus OX=10090 GN=Snx1 PE=1 SV=1 0.004 3.07 2 1 1 1 521 58.8 5.26 1 1 861731.3125 1344372.875 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endosome;Golgi;membrane;vacuole protein binding "Pf00787, Pf03700, Pf09325, Pf10456" 56440 ENSMUSG00000032382.14 Snx1 9 Endocytosis 0 Medium Q9QUH0 Glutaredoxin-1 OS=Mus musculus OX=10090 GN=Glrx PE=1 SV=3 0.026 1.804 8 1 1 1 107 11.9 8.37 1 1 172779.3906 212196.7969 239984.9531 1 1 1 Met-loss+Acetyl [N-Term] cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding "Pf00462, Pf13098, Pf13417" 93692 ENSMUSG00000021591.7 Glrx 13 Interconversion of nucleotide di- and triphosphates 0 Medium Q91X72 Hemopexin OS=Mus musculus OX=10090 GN=Hpx PE=1 SV=2 0.01 2.639 2 1 1 1 460 51.3 7.8 1 1 1711191.125 1 cellular homeostasis;metabolic process;regulation of biological process;transport extracellular metal ion binding;transporter activity Pf00045 15458 ENSMUSG00000030895.9 Hpx 7 Scavenging of heme from plasma 0 High Q5SVF9 THO complex subunit 5 homolog OS=Mus musculus OX=10090 GN=Thoc5 PE=1 SV=1 0.002 4.021 2 1 1 1 635 73 7.59 1 1 1006346.25 1092225 1 1 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytoplasm;nucleus protein binding;RNA binding Pf09766 107829 ENSMUSG00000034274.11 Thoc5 11 mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript 0 Medium A0A1B0GR60 Ferritin OS=Mus musculus OX=10090 GN=Ftl1 PE=1 SV=1 0.039 1.535 6 1 1 1 160 18 6.28 1 1 cellular homeostasis;transport metal ion binding Pf00210 ENSMUSG00000050708.16 7 Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport 0 Medium A3KGV1 Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 0.026 1.807 1 1 1 1 830 95.5 7.61 1 1 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf01608, Pf02463, Pf04111, Pf04156, Pf05557, Pf05622, Pf05701, Pf07888, Pf09726, Pf10174, Pf12128, Pf13514" 18286 ENSMUSG00000026790.19 Odf2 2 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes 0 High B1AUB9 Nuclear factor 1 OS=Mus musculus OX=10090 GN=Nfia PE=1 SV=1 0 5.258 5 1 1 1 487 53.6 9.01 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf00859, Pf03165, Pf10524" 18027 ENSMUSG00000028565.18 Nfia 4 0 Medium Q7TT35 Polyhomeotic-like 1 (Drosophila) OS=Mus musculus OX=10090 GN=Phc1 PE=1 SV=1 0.04 1.52 3 1 1 1 1010 106 9.19 1 1 cell organization and biogenesis;development;metabolic process;response to stimulus nucleus DNA binding;metal ion binding;protein binding "Pf00536, Pf06467, Pf07647" 13619 ENSMUSG00000040669.14 Phc1 6 Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 Medium P61027 Ras-related protein Rab-10 OS=Mus musculus OX=10090 GN=Rab10 PE=1 SV=1 0.029 1.668 6 1 1 1 200 22.5 8.38 1 1 506508 2801319.5 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf04670, Pf08477" 19325 ENSMUSG00000020671.9 Rab10 12 RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation Endocytosis; AMPK signaling pathway 0 Low A2AQJ7 Transmembrane protein 87A OS=Mus musculus OX=10090 GN=Tmem87a PE=1 SV=1 0.071 1.333 3 1 1 1 500 57 8.1 1 1 52048160 219344720 312482400 1 1 1 transport cytosol;Golgi;membrane Pf06814 211499 ENSMUSG00000033808.16 Tmem87a 2 0 Medium E9QKV6 Unconventional myosin-IXb OS=Mus musculus OX=10090 GN=Myo9b PE=1 SV=1 0.028 1.751 1 1 1 1 1961 222.3 8.4 1 1 52386.24219 359987.375 1771570.25 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;enzyme regulator activity;metal ion binding;motor activity;nucleotide binding;protein binding "Pf00063, Pf00130, Pf00612, Pf00620, Pf00788" 17925 ENSMUSG00000004677.17 Myo9b 8 Rho GTPase cycle; SLIT2:ROBO1 increases RHOA activity 0 Medium Q99MR6 Serrate RNA effector molecule homolog OS=Mus musculus OX=10090 GN=Srrt PE=1 SV=1 0.028 1.756 1 1 1 1 875 100.4 5.97 1 1 522805.0938 1 cell proliferation;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf04959, Pf12066" 83701 ENSMUSG00000037364.11 Srrt 5 mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes 0 High D3Z2U5 Inactive serine/threonine-protein kinase VRK3 (Fragment) OS=Mus musculus OX=10090 GN=Vrk3 PE=1 SV=9 0.004 3.104 6 1 1 1 175 19.4 9.19 1 1 156818.1719 555576.375 1 1 regulation of biological process nucleus protein binding "Pf10571, Pf12773, Pf13240, Pf13248" ENSMUSG00000002205.16 7 0 High O35218 Cleavage and polyadenylation specificity factor subunit 2 OS=Mus musculus OX=10090 GN=Cpsf2 PE=1 SV=1 0.003 3.723 2 1 1 1 782 88.3 5.11 1 1 88403.99219 265876.8125 1 1 metabolic process membrane;nucleus RNA binding "Pf00753, Pf07521, Pf10996, Pf12706, Pf13299" 51786 ENSMUSG00000041781.8 Cpsf2 12 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Processing of Intronless Pre-mRNAs; Cleavage of Growing Transcript in the Termination Region mRNA surveillance pathway 0 Medium O55013 Trafficking protein particle complex subunit 3 OS=Mus musculus OX=10090 GN=Trappc3 PE=1 SV=1 0.026 1.842 4 1 1 1 180 20.3 4.96 1 1 transport cytosol;endoplasmic reticulum;Golgi;membrane protein binding Pf04051 27096 ENSMUSG00000028847.8 Trappc3 4 COPII (Coat Protein 2) Mediated Vesicle Transport; RAB GEFs exchange GTP for GDP on RABs 0 Low Q07113 Cation-independent mannose-6-phosphate receptor OS=Mus musculus OX=10090 GN=Igf2r PE=1 SV=1 0.075 1.309 0 1 1 1 2483 273.6 5.71 1 1 149200.9375 594580.4375 1297325 1 1 1 regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;Golgi;membrane;nucleus;vacuole protein binding;receptor activity;signal transducer activity;transporter activity "Pf00040, Pf00878, Pf02157, Pf09451" 16004 ENSMUSG00000023830.13 Igf2r 17 Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis Endocytosis; Lysosome 0 High Q80UK0 SEC14 domain and spectrin repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Sestd1 PE=1 SV=1 0 6.738 4 1 1 1 696 79.3 5.1 1 1 529544.375 463548.7813 1 1 Pf13716 228071 ENSMUSG00000042272.17 Sestd1 2 0 Medium A0A0B4J1E2 SNW domain-containing protein 1 OS=Mus musculus OX=10090 GN=Snw1 PE=1 SV=1 0.041 1.49 2 1 1 1 536 61.4 9.48 1 1 638633.4375 699647.9375 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding Pf02731 66354 ENSMUSG00000021039.8 Snw1 12 NOTCH1 Intracellular Domain Regulates Transcription; mRNA Splicing - Major Pathway; RUNX3 regulates NOTCH signaling; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Notch-HLH transcription pathway Epstein-Barr virus infection; Spliceosome; Notch signaling pathway; Viral carcinogenesis 0 Medium H3BLC4 Harmonin OS=Mus musculus OX=10090 GN=Ush1c PE=1 SV=1 0.018 2.337 4 1 1 1 529 59.8 5.94 1 1 826922 1 protein binding "Pf00595, Pf13180" ENSMUSG00000030838.17 7 0 Low P03930 ATP synthase protein 8 OS=Mus musculus OX=10090 GN=Mtatp8 PE=1 SV=1 0.054 1.418 15 1 1 1 67 7.8 9.88 1 1 1191839.5 2014388.125 3055537.75 1 1 1 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;transporter activity Pf00895 17706; 3338900 ENSMUSG00000064356.3 ATP8 MT Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High F6X089 Merlin (Fragment) OS=Mus musculus OX=10090 GN=Nf2 PE=1 SV=1 0.002 3.907 29 1 1 1 83 9.7 5.8 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding "Pf00373, Pf09379" ENSMUSG00000009073.16 11 0 Medium A0A498WFM6 Geranylgeranyl transferase type-1 subunit beta OS=Mus musculus OX=10090 GN=Pggt1b PE=1 SV=1 0.049 1.444 12 1 1 1 97 11.4 7.52 1 1 113125008 1 0 High Q7TNE1 Succinate--hydroxymethylglutarate CoA-transferase OS=Mus musculus OX=10090 GN=Sugct PE=1 SV=2 0 4.992 5 1 1 1 436 47.7 8.68 1 1 metabolic process mitochondrion catalytic activity Pf02515 192136 ENSMUSG00000055137.6 5033411D12Rik; Sugct 13 0 Medium P0DN34 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 OS=Mus musculus OX=10090 GN=Ndufb1 PE=1 SV=1 0.035 1.602 19 1 1 1 57 7 8.21 1 1 342533.7813 572349.25 887855.5625 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity Pf08040 102631912 LOC102631912 12 0 Medium Q14AA6 GTP-binding nuclear protein Ran OS=Mus musculus OX=10090 GN=1700009N14Rik PE=2 SV=1 0.023 1.93 5 1 1 1 216 24.3 7.97 1 1 346380.3125 918535.5 1 1 regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf08477" 75471 ENSMUSG00000028287.4 1700009N14Rik 4 Epstein-Barr virus infection; HTLV-I infection; Ribosome biogenesis in eukaryotes; RNA transport 0 Medium E9PWX9 Transmembrane protease serine 5 OS=Mus musculus OX=10090 GN=Tmprss5 PE=1 SV=1 0.035 1.589 4 1 1 1 381 41.7 7.5 1 1 314546.375 648921.125 1015515.563 1 1 1 Met-loss+Acetyl [N-Term] metabolic process;transport membrane catalytic activity;receptor activity "Pf00089, Pf09342, Pf15494" ENSMUSG00000032268.13 9 0 High P01671 Ig kappa chain V-III region PC 7175 OS=Mus musculus OX=10090 PE=1 SV=1 0.002 3.832 16 1 1 1 111 12 7.37 1 1 "Pf00047, Pf07679, Pf07686" 0 Medium A0A3B2WB60 Mitogen-activated protein kinase OS=Mus musculus OX=10090 GN=Mapk14 PE=1 SV=1 0.01 2.53 5 1 1 1 307 35.3 8.97 1 1 442991.1563 724430.75 928895.625 1 1 1 0 High Q4FZG7 Putative mitochondrial import inner membrane translocase subunit Tim8 A-B OS=Mus musculus OX=10090 GN=Timm8a2 PE=3 SV=1 0.003 3.351 11 1 1 1 97 11.3 6.52 1 1 transport membrane;mitochondrion metal ion binding Pf02953 223262 ENSMUSG00000071229.3 Timm8a2 14 0 Medium Q924T2 "28S ribosomal protein S2, mitochondrial OS=Mus musculus OX=10090 GN=Mrps2 PE=1 SV=1" 0.013 2.449 3 1 1 1 291 32.3 9.14 1 1 274565.5313 366893.7813 492948.875 1 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome structural molecule activity Pf00318 118451 ENSMUSG00000035772.11 Mrps2 2 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Medium Q9DCJ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Mus musculus OX=10090 GN=Ndufa8 PE=1 SV=3 0.017 2.401 10 1 1 1 172 20 8.46 1 1 315715.3125 432462.75 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion protein binding Pf06747 68375 ENSMUSG00000026895.7 Ndufa8 2 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q99L20 Glutathione S-transferase theta-3 OS=Mus musculus OX=10090 GN=Gstt3 PE=1 SV=1 0.002 4.37 6 1 1 1 241 27.4 7.74 1 1 metabolic process cytoplasm catalytic activity;protein binding "Pf00043, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497" 103140 ENSMUSG00000001665.11 Gstt3 10 Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 Medium A0A0R4J0Q6 E3 ubiquitin-protein ligase TRIM56 OS=Mus musculus OX=10090 GN=Trim56 PE=1 SV=1 0.023 1.908 1 1 1 1 734 79.5 7.88 1 1 155828.8594 373899.2813 465150.0938 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00643, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227" 384309 ENSMUSG00000043279.9 Trim56 5 Regulation of innate immune responses to cytosolic DNA 0 Low G3UZ78 Androglobin OS=Mus musculus OX=10090 GN=Adgb PE=1 SV=1 0.075 1.306 2 1 1 1 1657 188.4 8.13 1 1 703167.25 926801.1875 1 1 metabolic process cytoplasm catalytic activity;protein binding 215772 ENSMUSG00000050994.20 9130014G24Rik; Adgb 10 0 High Q99N87 "28S ribosomal protein S5, mitochondrial OS=Mus musculus OX=10090 GN=Mrps5 PE=1 SV=1" 0.01 2.756 3 1 1 1 432 48.2 10.14 1 1 235182.2813 825126.125 1524568 1 1 1 metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf03719 77721 ENSMUSG00000027374.12 Mrps5 2 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High O54734 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Mus musculus OX=10090 GN=Ddost PE=1 SV=2 0.003 3.518 2 1 1 1 441 49 5.83 1 1 866586 1 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf03345 13200 ENSMUSG00000028757.4 Ddost 4 Neutrophil degranulation Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High Q78JT3 "3-hydroxyanthranilate 3,4-dioxygenase OS=Mus musculus OX=10090 GN=Haao PE=1 SV=1" 0 8.092 7 1 1 1 286 32.8 6.54 1 1 282442.0313 440630.25 1631165.25 1 1 1 cellular homeostasis;metabolic process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding "Pf06052, Pf07883" 107766 ENSMUSG00000000673.8 Haao 17 Tryptophan catabolism Tryptophan metabolism; Metabolic pathways 0 Low Q9DC71 "28S ribosomal protein S15, mitochondrial OS=Mus musculus OX=10090 GN=Mrps15 PE=1 SV=2" 0.07 1.343 3 1 1 1 258 29.4 10.13 1 1 793967.8125 1 cell organization and biogenesis;metabolic process mitochondrion;nucleus;ribosome RNA binding;structural molecule activity Pf00312 66407 ENSMUSG00000028861.13 Mrps15 4 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Medium P14602 Heat shock protein beta-1 OS=Mus musculus OX=10090 GN=Hspb1 PE=1 SV=3 0.01 2.488 8 1 1 1 209 23 6.55 1 1 101151.75 1864054.375 2049018.75 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus;proteasome enzyme regulator activity;protein binding;RNA binding Pf00011 15507 ENSMUSG00000004951.10 Hspb1 5 VEGFA-VEGFR2 Pathway; AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling MAPK signaling pathway; VEGF signaling pathway; Epstein-Barr virus infection; Amoebiasis 0 Medium P03921 NADH-ubiquinone oxidoreductase chain 5 OS=Mus musculus OX=10090 GN=Mtnd5 PE=1 SV=3 0.049 1.442 2 1 1 1 607 68.4 9.03 1 1 40718.42188 447584.3438 413186.4688 1 1 1 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity "Pf00361, Pf00662, Pf06455" 17721; 3338890 ENSMUSG00000064367.1 ND5 MT Complex I biogenesis Metabolic pathways; Oxidative phosphorylation; Parkinson's disease 0 Medium Q9ER65 Calsyntenin-2 OS=Mus musculus OX=10090 GN=Clstn2 PE=1 SV=2 0.034 1.621 3 1 1 1 966 107.8 5.68 1 1 regulation of biological process cell surface;endoplasmic reticulum;Golgi;membrane metal ion binding "Pf00028, Pf13385" 64085 ENSMUSG00000032452.12 Clstn2 9 0 Medium Q5RKZ7 Molybdenum cofactor biosynthesis protein 1 OS=Mus musculus OX=10090 GN=Mocs1 PE=1 SV=2 0.023 2.088 1 1 1 1 636 69.8 9.14 1 1 583810.375 650189.6875 1745056.375 1 1 1 metabolic process catalytic activity;metal ion binding;nucleotide binding "Pf01967, Pf04055, Pf06463, Pf13394" 56738 ENSMUSG00000064120.13 Mocs1 17 Molybdenum cofactor biosynthesis Metabolic pathways; Folate biosynthesis 0 High Q9CZU6 "Citrate synthase, mitochondrial OS=Mus musculus OX=10090 GN=Cs PE=1 SV=1" 0 4.604 2 1 1 1 464 51.7 8.57 1 1 375570 629536.4375 1 1 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;RNA binding Pf00285 12974 ENSMUSG00000005683.8 Cs 10 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 Medium D3Z4Z0 Transcriptional adapter OS=Mus musculus OX=10090 GN=Tada2b PE=4 SV=1 0.025 1.84 2 1 1 1 420 48.5 7.83 1 1 713070.3125 4996365 5520099 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00249, Pf04433, Pf13921" 231151 ENSMUSG00000029196.9 Tada2b 5 Ub-specific processing proteases 0 Low D3YTR6 Protein spinster homolog 1 OS=Mus musculus OX=10090 GN=Spns1 PE=1 SV=1 0.085 1.264 7 1 1 1 476 51.4 7.44 1 1 22098422 13346451 14849652 1 1 1 Met-loss [N-Term] transport membrane transporter activity "Pf00083, Pf07690" ENSMUSG00000030741.15 7 0 High A0A140T8P7 Immunoglobulin kappa variable 8-21 (Fragment) OS=Mus musculus OX=10090 GN=Igkv8-21 PE=1 SV=2 0.006 3.002 13 1 1 1 120 13.1 8.28 1 1 507859.8438 1 Pf07686 620400 ENSMUSG00000076586.2 Igkv8-21 6 0 Low O70378 ER membrane protein complex subunit 8 OS=Mus musculus OX=10090 GN=Emc8 PE=1 SV=1 0.06 1.388 4 1 1 1 207 23.3 6.15 1 1 384625.4063 1 cytoplasm;cytosol;membrane;mitochondrion Pf03665 18117 ENSMUSG00000031819.13 Emc8 8 0 High Q91VR8 Protein BRICK1 OS=Mus musculus OX=10090 GN=Brk1 PE=1 SV=1 0.003 3.71 15 1 1 1 75 8.8 5.45 1 1 1408922.75 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton protein binding 101314 ENSMUSG00000033940.8 Brk1 6 RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation Regulation of actin cytoskeleton 0 Medium P62627 Dynein light chain roadblock-type 1 OS=Mus musculus OX=10090 GN=Dynlrb1 PE=1 SV=3 0.017 2.367 10 1 1 1 96 11 7.25 1 1 600722.75 1348676.875 1 1 Met-loss+Acetyl [N-Term] cellular component movement;response to stimulus;transport cytoplasm;cytoskeleton;membrane catalytic activity;motor activity;protein binding Pf03259 67068 ENSMUSG00000047459.14 Dynlrb1 2 Intraflagellar transport 0 Medium Q8CGA3 Large neutral amino acids transporter small subunit 4 OS=Mus musculus OX=10090 GN=Slc43a2 PE=1 SV=1 0.029 1.65 2 1 1 1 568 62.4 7.93 1 1 492567.3125 1 transport membrane transporter activity Pf07690 215113 ENSMUSG00000038178.16 Slc43a2 11 Amino acid transport across the plasma membrane 0 Medium Q7TQJ3 Fructosamine-3-kinase OS=Mus musculus OX=10090 GN=Fn3k PE=1 SV=1 0.035 1.575 8 1 1 1 208 22.7 8.73 1 1 metabolic process cytosol catalytic activity "Pf01163, Pf01636, Pf03881" 63828 ENSMUSG00000025175.12 Fn3k 11 0 Medium O54774 AP-3 complex subunit delta-1 OS=Mus musculus OX=10090 GN=Ap3d1 PE=1 SV=1 0.01 2.604 2 1 1 1 1199 135 7.37 1 1 399383.8125 1163763 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;Golgi;membrane "Pf01602, Pf06375" 11776 ENSMUSG00000020198.8 Ap3d1 10 Lysosome 0 Medium Q80U19 Disheveled-associated activator of morphogenesis 2 OS=Mus musculus OX=10090 GN=Daam2 PE=1 SV=4 0.018 2.245 1 1 1 1 1115 128.3 6.92 1 1 321385.1563 1 cell organization and biogenesis protein binding "Pf02181, Pf06367, Pf06371" 76441 ENSMUSG00000040260.7 Daam2 17 Wnt signaling pathway 0 Medium Q9CQD4 Charged multivesicular body protein 1b-2 OS=Mus musculus OX=10090 GN=Chmp1b2 PE=2 SV=2 0.028 1.768 4 1 1 1 199 22.1 8.1 1 1 674765.6875 1 cell division;transport cytoplasm;cytosol;endosome;membrane Pf03357 67028 ENSMUSG00000031242.7 2610002M06Rik X Endocytosis 0 Medium Q5SSE9 ATP-binding cassette sub-family A member 13 OS=Mus musculus OX=10090 GN=Abca13 PE=2 SV=1 0.039 1.539 1 1 1 1 5034 568.5 6.52 1 1 transport membrane catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf12698, Pf13304" 268379 ENSMUSG00000004668.14 Abca13 11 Neutrophil degranulation ABC transporters 0 Medium Q91XE4 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) OS=Mus musculus OX=10090 GN=Acy3 PE=1 SV=1 0.021 2.22 3 1 1 1 318 35.3 5.5 1 1 96970.0625 279719.0938 492045.8438 1 1 1 metabolic process cytoplasm;membrane catalytic activity;metal ion binding;protein binding Pf04952 71670 ENSMUSG00000024866.9 Acy3 19 Aflatoxin activation and detoxification 0 High Q810B6 Rabankyrin-5 OS=Mus musculus OX=10090 GN=Ankfy1 PE=1 SV=2 0.003 3.555 1 1 1 1 1169 128.6 5.91 1 1 150557.9219 859994.9375 748181.1875 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endosome;membrane metal ion binding;protein binding "Pf00023, Pf00651, Pf01363, Pf07707, Pf12796, Pf13606, Pf13637, Pf13857" 11736 ENSMUSG00000020790.14 Ankfy1 11 0 Low Q9CYI4 Putative RNA-binding protein Luc7-like 1 OS=Mus musculus OX=10090 GN=Luc7l PE=1 SV=2 0.086 1.244 2 1 1 1 371 43.9 9.88 1 1 cell organization and biogenesis;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding Pf03194 66978 ENSMUSG00000024188.15 Luc7l 17 0 Medium G3XA26 Carbonic anhydrase 7 OS=Mus musculus OX=10090 GN=Car7 PE=1 SV=1 0.034 1.619 5 1 1 1 208 23.6 7.64 1 1 438362.4375 552386.75 1 1 metabolic process;regulation of biological process cytoplasm;cytosol catalytic activity;metal ion binding Pf00194 12354 ENSMUSG00000031883.13 Car7 8 0 Low Q9R1R8 Retinol dehydrogenase 11 OS=Mus musculus OX=10090 GN=Rdh11 PE=1 SV=1 0.072 1.321 6 1 1 1 300 33.2 8.79 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity "Pf00106, Pf08659, Pf13460" 17252 ENSMUSG00000066441.14 Rdh11 12 0 Low A0A0G2JF72 Cold shock domain-containing protein E1 OS=Mus musculus OX=10090 GN=Csde1 PE=1 SV=1 0.087 1.219 1 1 1 1 668 74.4 6.18 1 1 100127.1172 260324.7656 381566.5 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;membrane DNA binding;RNA binding "Pf00313, Pf12901" 229663 ENSMUSG00000068823.10 Csde1 3 0 Medium Q60936 "Atypical kinase COQ8A, mitochondrial OS=Mus musculus OX=10090 GN=Coq8a PE=1 SV=2" 0.012 2.461 4 1 1 1 645 71.7 6.54 1 1 238069.3281 699257.1875 873795.25 1 1 1 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding Pf03109 67426 ENSMUSG00000026489.13 Adck3; Coq8a 1 0 Medium Q61033 "Lamina-associated polypeptide 2, isoforms alpha/zeta OS=Mus musculus OX=10090 GN=Tmpo PE=1 SV=4" 0.033 1.639 2 1 1 1 693 75.1 8.05 1 1 164042.5781 559884.4375 344069.5625 1 1 1 regulation of biological process chromosome;membrane;nucleus DNA binding;protein binding "Pf03020, Pf08198, Pf11560" 21917 ENSMUSG00000019961.17 Tmpo 10 0 Low Q9DBS5 Kinesin light chain 4 OS=Mus musculus OX=10090 GN=Klc4 PE=1 SV=1 0.09 1.185 1 1 1 1 619 68.6 6.09 1 1 210246.2656 592807.9375 1 1 cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding "Pf00515, Pf09311, Pf13374, Pf13414, Pf13424, Pf13432, Pf14559" 74764 ENSMUSG00000003546.9 Klc4 17 Salmonella infection 0 High Q80YX1 Tenascin OS=Mus musculus OX=10090 GN=Tnc PE=1 SV=1 0.003 3.658 1 1 1 1 2110 231.7 4.89 1 1 cell communication;cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00041, Pf00147, Pf07974" 21923 ENSMUSG00000028364.15 Tnc 4 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ECM proteoglycans; Post-translational protein phosphorylation; Integrin cell surface interactions MicroRNAs in cancer; Focal adhesion; ECM-receptor interaction; PI3K-Akt signaling pathway 0 Low Q8BFW7 Lipoma-preferred partner homolog OS=Mus musculus OX=10090 GN=Lpp PE=1 SV=1 0.077 1.3 2 1 1 1 613 65.8 7.37 1 1 124735.9453 2237636.75 1 1 cytoplasm;cytosol;nucleus metal ion binding;protein binding "Pf00412, Pf02318" 210126 ENSMUSG00000033306.14 Lpp 16 0 Medium A0A075B5R5 Immunoglobulin heavy variable 4-1 (Fragment) OS=Mus musculus OX=10090 GN=Ighv4-1 PE=1 SV=7 0.01 2.48 10 1 1 1 116 12.9 8.9 1 1 64128.71875 502983.2813 351397.9375 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus protein binding Pf07686 ENSMUSG00000076655.2 LOC668418 12 0 High Q8K019 Bcl-2-associated transcription factor 1 OS=Mus musculus OX=10090 GN=Bclaf1 PE=1 SV=2 0.002 4.238 2 1 1 1 919 105.9 9.99 1 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding Pf15440 72567 ENSMUSG00000037608.16 Bclaf1 10 0 High P26516 26S proteasome non-ATPase regulatory subunit 7 OS=Mus musculus OX=10090 GN=Psmd7 PE=1 SV=2 0 4.614 9 1 1 1 321 36.5 6.77 1 1 metabolic process membrane;nucleus;proteasome protein binding "Pf01398, Pf13012" 17463 ENSMUSG00000039067.5 Psmd7 8 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High Q99L45 Eukaryotic translation initiation factor 2 subunit 2 OS=Mus musculus OX=10090 GN=Eif2s2 PE=1 SV=1 0.003 3.342 3 1 1 1 331 38.1 5.8 1 1 721075.125 1 cell proliferation;metabolic process cytoplasm metal ion binding;protein binding;RNA binding Pf01873 67204 ENSMUSG00000074656.12 Eif2s2 2 "L13a-mediated translational silencing of Ceruloplasmin expression; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" RNA transport 0 Medium Q9Z2C6 Uroplakin-1b OS=Mus musculus OX=10090 GN=Upk1b PE=2 SV=3 0.017 2.417 4 1 1 1 260 29.7 5.82 1 1 169700.0625 607007.375 2202837.5 1 1 1 cell differentiation;regulation of biological process;response to stimulus membrane Pf00335 22268 ENSMUSG00000049436.4 Upk1b 16 0 Medium Q8C7H1 "Methylmalonic aciduria type A homolog, mitochondrial OS=Mus musculus OX=10090 GN=Mmaa PE=1 SV=1" 0.017 2.39 2 1 1 1 415 45.9 9.32 1 1 113637.2891 792340 1480030.5 1 1 1 metabolic process mitochondrion catalytic activity;nucleotide binding "Pf02492, Pf03205, Pf03308, Pf12846" 109136 ENSMUSG00000037022.3 Mmaa 8 "Propionyl-CoA catabolism; Cobalamin (Cbl, vitamin B12) transport and metabolism" 0 Medium P28481 Collagen alpha-1(II) chain OS=Mus musculus OX=10090 GN=Col2a1 PE=1 SV=2 0.027 1.733 1 1 1 1 1487 141.9 6.92 1 1 280808.5 626505.125 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular metal ion binding;protein binding;structural molecule activity "Pf00093, Pf01391, Pf01410, Pf14828" 12824 ENSMUSG00000022483.16 Col2a1 15 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; MET activates PTK2 signaling; NCAM1 interactions; Collagen degradation; Non-integrin membrane-ECM interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures Focal adhesion; Protein digestion and absorption; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q8C190 VPS9 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Vps9d1 PE=1 SV=1 0.006 2.955 3 1 1 1 649 71.2 6.87 1 1 Met-loss+Acetyl [N-Term] Pf02204 72325 ENSMUSG00000001062.18 1300018I17Rik; Vps9d1 8 0 High P62309 Small nuclear ribonucleoprotein G OS=Mus musculus OX=10090 GN=Snrpg PE=1 SV=1 0.003 3.631 16 1 1 1 76 8.5 8.88 1 1 1142843.375 1215294.125 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex RNA binding;structural molecule activity "Pf01423, Pf03122" 68011 ENSMUSG00000049124.3; ENSMUSG00000057278.8 Snrpg 6; 17 mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; mRNA Splicing - Major Pathway; snRNP Assembly; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs Spliceosome 0 Low O35452 Tenascin X OS=Mus musculus OX=10090 GN=Tnxb PE=1 SV=1 0.082 1.277 3 1 1 1 4006 435.2 5.22 1 1 297706.3125 479882.4375 288574.9063 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process extracellular protein binding "Pf00041, Pf00147, Pf04885, Pf07974" 81877 ENSMUSG00000033327.16 Tnxb 17 0 Low J3QNW9 Kinesin-like protein KIF7 OS=Mus musculus OX=10090 GN=Kif7 PE=1 SV=1 0.084 1.255 2 1 1 1 1348 151.6 6.57 1 1 168458000 148393696 207494736 1 1 1 cellular component movement;regulation of biological process cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf09726" 16576 ENSMUSG00000050382.14 Kif7 7 Hedgehog 'on' state; Hedgehog 'off' state Hedgehog signaling pathway 0 Medium F6V6T4 Transmembrane emp24 domain-containing protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Tmed2 PE=1 SV=1 0.021 2.204 5 1 1 1 176 20 9.07 1 1 582920.25 1 regulation of biological process;transport membrane Pf01105 ENSMUSG00000029390.13 5 0 High Q04750 DNA topoisomerase 1 OS=Mus musculus OX=10090 GN=Top1 PE=1 SV=2 0.003 3.165 1 1 1 1 767 90.8 9.33 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf01028, Pf02919, Pf14370" 21969 ENSMUSG00000070544.6 Top1 2 SUMOylation of DNA replication proteins 0 Medium Q3UYV9 Nuclear cap-binding protein subunit 1 OS=Mus musculus OX=10090 GN=Ncbp1 PE=1 SV=2 0.017 2.318 2 1 1 1 790 91.9 6.64 1 1 364014.9063 734848.5625 570684.5 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;mitochondrion;nucleus protein binding;RNA binding "Pf02854, Pf09088, Pf09090" 433702 ENSMUSG00000028330.8 Ncbp1 4 mRNA Capping; RNA Polymerase II Pre-transcription Events; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; mRNA Splicing - Major Pathway; snRNP Assembly; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Processing of Intronless Pre-mRNAs; RNA polymerase II transcribes snRNA genes; Formation of the Early Elongation Complex; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; SLBP independent Processing of Histone Pre-mRNAs mRNA surveillance pathway; Spliceosome; RNA transport 0 Medium A2AC16 L-xylulose reductase OS=Mus musculus OX=10090 GN=Dcxr PE=1 SV=1 0.04 1.529 4 1 1 1 236 25 6.55 1 1 327456.875 1 cell organization and biogenesis;metabolic process membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00106, Pf01488, Pf02826, Pf03435, Pf05368, Pf08659, Pf13460, Pf13561" 67880 ENSMUSG00000039450.11 Dcxr 11 0 Medium E9PYP7 Trehalase OS=Mus musculus OX=10090 GN=Treh PE=1 SV=1 0.01 2.707 2 1 1 1 541 60.8 8.6 1 1 metabolic process membrane catalytic activity Pf01204 58866 ENSMUSG00000032098.13 Treh 9 0 Medium Q05D44 Eukaryotic translation initiation factor 5B OS=Mus musculus OX=10090 GN=Eif5b PE=1 SV=2 0.023 2.047 1 1 1 1 1216 137.5 5.59 1 1 207447.75 479699.0313 1 1 metabolic process;regulation of biological process cytoplasm catalytic activity;metal ion binding;nucleotide binding;RNA binding "Pf00009, Pf01926, Pf03144, Pf11987, Pf14578" 226982 ENSMUSG00000026083.12 Eif5b 1 Cap-dependent Translation Initiation; GTP hydrolysis and joining of the 60S ribosomal subunit RNA transport 0 Medium Q61581 Insulin-like growth factor-binding protein 7 OS=Mus musculus OX=10090 GN=Igfbp7 PE=1 SV=3 0.01 2.479 6 1 1 1 281 29 8.31 1 1 regulation of biological process extracellular protein binding "Pf07648, Pf07679" 29817 Igfbp7 5 0 Medium Q9EPK2 Protein XRP2 OS=Mus musculus OX=10090 GN=Rp2 PE=1 SV=3 0.021 2.163 2 1 1 1 347 39.4 5.24 1 1 793340.875 1220186 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;Golgi;membrane catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00334, Pf07986" 19889 ENSMUSG00000060090.16 Rp2h; Rp2 X Trafficking of myristoylated proteins to the cilium 0 Medium A0A075B5Q2 Immunoglobulin heavy variable 5-9 (Fragment) OS=Mus musculus OX=10090 GN=Ighv5-9 PE=4 SV=1 0.028 1.684 9 1 1 1 117 12.8 8.92 1 1 1215101.75 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus protein binding ENSMUSG00000095285.2 LOC674130 12 0 Medium A0A0N4SW73 Rab11 family-interacting protein 5 OS=Mus musculus OX=10090 GN=Rab11fip5 PE=1 SV=1 0.023 2.003 1 1 1 1 1318 139.5 5.12 1 1 197729.7031 393135.3125 1 1 regulation of biological process;response to stimulus;transport cytoplasm;endosome;Golgi;membrane;mitochondrion protein binding "Pf00168, Pf09457" 52055 ENSMUSG00000051343.11 Rab11fip5 6 0 High P01663 Ig kappa chain V-III region PC 4050 OS=Mus musculus OX=10090 PE=1 SV=1 0 6.629 16 1 1 1 111 12 5.06 1 1 "Pf00047, Pf07679, Pf07686, Pf13927" 0 High O88952 Protein lin-7 homolog C OS=Mus musculus OX=10090 GN=Lin7c PE=1 SV=2 0.002 4.508 8 1 1 1 197 21.8 8.43 1 1 779181 1 cell organization and biogenesis;transport cytoplasm;membrane protein binding "Pf00595, Pf02828, Pf09829" 22343 ENSMUSG00000027162.7 Lin7c 2 Dopamine Neurotransmitter Release Cycle 0 Medium Q8VDJ3 Vigilin OS=Mus musculus OX=10090 GN=Hdlbp PE=1 SV=1 0.023 1.872 1 1 1 1 1268 141.7 6.87 1 1 258946.1875 399471.3125 1 1 metabolic process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00013, Pf13014, Pf14611" 110611 ENSMUSG00000034088.15 Hdlbp 1 HDL clearance 0 Medium Q78IK2 "ATP synthase membrane subunit DAPIT, mitochondrial OS=Mus musculus OX=10090 GN=Atp5md PE=1 SV=1" 0.017 2.365 28 1 1 1 58 6.4 9.83 1 1 Met-loss [N-Term] membrane;mitochondrion Pf14960 66477; 102642507 ENSMUSG00000071528.3 Usmg5; LOC100504912; LOC102642507 19; 4 0 High E0CZ22 Maestro heat-like repeat family member 1 OS=Mus musculus OX=10090 GN=Mroh1 PE=1 SV=1 0.003 3.273 1 1 1 1 1640 181.7 6.39 1 1 226999.4063 327758.6563 1 1 223658 ENSMUSG00000022558.15 Heatr7a; Mroh1 15 0 Low Q9QZZ4 Unconventional myosin-XV OS=Mus musculus OX=10090 GN=Myo15a PE=1 SV=2 0.072 1.325 0 1 1 1 3511 395.4 9.16 1 1 1372629.5 2504248.5 3991527.75 1 1 1 response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00373, Pf00784, Pf07653" 17910 ENSMUSG00000042678.16 Myo15 11 0 High Q91XH6 Vesicle transport through interaction with t-SNAREs 1B homolog OS=Mus musculus OX=10090 GN=Vti1b PE=1 SV=1 0.003 3.388 5 1 1 1 232 26.7 9.04 1 1 391850.8125 1 cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;Golgi;membrane;vacuole protein binding "Pf03908, Pf05008, Pf12352" 53612 ENSMUSG00000021124.13 Vti1b 12 Platelet degranulation SNARE interactions in vesicular transport 0 Medium Q8CB62 Centrobin OS=Mus musculus OX=10090 GN=Cntrob PE=2 SV=2 0.039 1.548 2 1 1 1 887 99.3 5.55 1 1 3271874.75 6975917.5 1 1 cell division;cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol catalytic activity;motor activity;protein binding "Pf01576, Pf02463, Pf04111, Pf04156, Pf06785, Pf09726, Pf12128" 216846 ENSMUSG00000032782.19 Cntrob 11 0 Low Q8CDA1 Phosphatidylinositide phosphatase SAC2 OS=Mus musculus OX=10090 GN=Inpp5f PE=1 SV=1 0.061 1.391 2 1 1 1 1132 127.5 7.11 1 1 411632.5 369943.375 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endosome;membrane catalytic activity;protein binding "Pf02383, Pf12456" 101490 ENSMUSG00000042105.18 Inpp5f 7 Synthesis of PIPs at the early endosome membrane 0 High Q9JKX8 Uroplakin-3a OS=Mus musculus OX=10090 GN=Upk3a PE=1 SV=3 0 5.746 12 1 1 1 287 31 4.73 1 1 cell differentiation;cell organization and biogenesis;transport endoplasmic reticulum;membrane protein binding 22270 ENSMUSG00000022435.5 Upk3a 15 Bladder cancer 0 Medium E9PVA8 eIF-2-alpha kinase activator GCN1 OS=Mus musculus OX=10090 GN=Gcn1 PE=1 SV=1 0.01 2.743 1 1 1 1 2671 292.8 7.36 1 1 cell communication;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf12074, Pf13646" 231659 ENSMUSG00000041638.18 Gcn1l1 5 0 Low Q8C5W3 Tubulin-specific chaperone cofactor E-like protein OS=Mus musculus OX=10090 GN=Tbcel PE=1 SV=1 0.088 1.227 1 1 1 1 424 48 5.53 1 1 403846.9063 1067957.25 1 1 cytoplasm;cytoskeleton protein binding "Pf12799, Pf14560, Pf14580" 272589 ENSMUSG00000037287.15 Tbcel 9 0 Medium P04117 "Fatty acid-binding protein, adipocyte OS=Mus musculus OX=10090 GN=Fabp4 PE=1 SV=3" 0.048 1.449 9 1 1 1 132 14.6 8.4 1 1 237772.375 649042.25 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus transporter activity Pf00061 11770 ENSMUSG00000062515.3 Fabp4 3 Triglyceride catabolism; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes PPAR signaling pathway; Regulation of lipolysis in adipocytes 0 Medium Q80TI0 Protein Aster-B OS=Mus musculus OX=10090 GN=Gramd1b PE=1 SV=2 0.023 1.942 1 1 1 1 738 85.3 6.14 1 1 586390.6875 686005.25 1 1 membrane Pf02893 235283 Gramd1b 9 0 High G3UY72 Alpha-aminoadipic semialdehyde dehydrogenase (Fragment) OS=Mus musculus OX=10090 GN=Aldh7a1 PE=1 SV=1 0.002 3.855 4 1 1 1 321 35.1 8.28 1 1 226795.8906 610130.6875 1 1 metabolic process catalytic activity Pf00171 ENSMUSG00000053644.13 18 0 Low Q91XU3 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Mus musculus OX=10090 GN=Pip4k2c PE=1 SV=1 0.071 1.334 2 1 1 1 421 47.3 6.89 1 1 442910.1875 1 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;vacuole catalytic activity;nucleotide binding;protein binding Pf01504 117150 ENSMUSG00000025417.8 Pip4k2c 10 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Synthesis of PIPs at the plasma membrane" Regulation of actin cytoskeleton; Inositol phosphate metabolism; Phosphatidylinositol signaling system 0 Medium D3YTL8 Protein spire homolog 1 OS=Mus musculus OX=10090 GN=Spire1 PE=1 SV=1 0.013 2.448 2 1 1 1 643 73.5 9.22 1 1 435578.0938 215353.3281 1 1 cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane protein binding 68166 ENSMUSG00000024533.15 Spire1 18 0 High A0A0A6YWN9 Ubiquitin carboxyl-terminal hydrolase (Fragment) OS=Mus musculus OX=10090 GN=Usp19 PE=1 SV=1 0.009 2.866 2 1 1 1 991 110.5 6.67 1 1 metabolic process;regulation of biological process cytosol;membrane catalytic activity;metal ion binding;protein binding "Pf00443, Pf01753, Pf04969, Pf13423, Pf14533" ENSMUSG00000006676.16 9 0 Low Q9WVJ2 26S proteasome non-ATPase regulatory subunit 13 OS=Mus musculus OX=10090 GN=Psmd13 PE=1 SV=1 0.09 1.19 3 1 1 1 376 42.8 5.71 1 1 534195.625 598570.0625 429390.6563 1 1 1 cell organization and biogenesis;metabolic process cytosol;membrane;nucleus;proteasome catalytic activity;protein binding;structural molecule activity Pf01399 23997 ENSMUSG00000025487.15 Psmd13 7 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 Medium Q8K411 "Presequence protease, mitochondrial OS=Mus musculus OX=10090 GN=Pitrm1 PE=1 SV=1" 0.01 2.666 1 1 1 1 1036 117.3 7.2 1 1 649253 1 metabolic process mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf00675, Pf05193, Pf08367" 69617 ENSMUSG00000021193.9 Pitrm1 13 0 Medium Q07417 "Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acads PE=1 SV=2" 0.01 2.745 3 1 1 1 412 44.9 8.47 1 1 182026.4219 529398.4375 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 11409 ENSMUSG00000029545.13 Acads 5 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA "Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; Butanoate metabolism; Carbon metabolism" 0 Low A2AVP4 Roquin-2 OS=Mus musculus OX=10090 GN=Rc3h2 PE=1 SV=1 0.075 1.31 1 1 1 1 1125 124.6 7.2 1 1 2400308.5 2752781.25 7931339 1 1 1 cell differentiation;cell proliferation;metabolic process;regulation of biological process cell surface;cytoplasm;membrane catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00097, Pf00642, Pf13445, Pf13639, Pf13923, Pf14634, Pf15227" 319817 ENSMUSG00000075376.10 Rc3h2 2 0 Medium Q8BJZ4 "28S ribosomal protein S35, mitochondrial OS=Mus musculus OX=10090 GN=Mrps35 PE=1 SV=2" 0.023 2.074 3 1 1 1 320 36 8.59 1 1 738298.8125 461834.1563 1595657.75 1 1 1 mitochondrion;ribosome RNA binding;structural molecule activity Pf10213 232536 Mrps35 6 0 Medium Q8BH43 Wiskott-Aldrich syndrome protein family member 2 OS=Mus musculus OX=10090 GN=Wasf2 PE=1 SV=1 0.023 1.926 2 1 1 1 497 54 5.53 1 1 80028.10938 352542.1875 762059.3125 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;endosome protein binding 242687 ENSMUSG00000028868.13 Wasf2 4 RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation Regulation of actin cytoskeleton; Adherens junction; Salmonella infection; Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Bacterial invasion of epithelial cells 0 Medium A0A075B5L7 Immunoglobulin kappa variable 4-80 (Fragment) OS=Mus musculus OX=10090 GN=Igkv4-80 PE=4 SV=2 0.028 1.766 14 1 1 1 116 12.6 5.15 1 1 3931030 2111855.75 1 1 response to stimulus "Pf00047, Pf07679, Pf07686" 545848 ENSMUSG00000076540.3 Igkv4-80 6 0 Medium A0A1Y7VN70 "Glutaredoxin-related protein 5, mitochondrial OS=Mus musculus OX=10090 GN=Glrx5 PE=1 SV=1" 0.018 2.329 16 1 1 1 118 12.2 7.18 1 1 cellular homeostasis;metabolic process;regulation of biological process catalytic activity Pf00462 0 Medium Q9CQZ1 Heat shock factor-binding protein 1 OS=Mus musculus OX=10090 GN=Hsbp1 PE=1 SV=1 0.021 2.141 25 1 1 1 76 8.6 4.31 1 1 23212.93359 269684.4688 300186.9063 1 1 1 cell differentiation;regulation of biological process cytoskeleton;nucleus protein binding Pf06825 68196 ENSMUSG00000031839.7 Hsbp1 8 Attenuation phase 0 Medium D3Z5P8 Mitofusin-1 (Fragment) OS=Mus musculus OX=10090 GN=Mfn1 PE=1 SV=1 0.01 2.512 4 1 1 1 239 26.8 6.61 1 1 cell organization and biogenesis membrane;mitochondrion catalytic activity;nucleotide binding "Pf00350, Pf01926" ENSMUSG00000027668.13 3 0 Low P58064 "28S ribosomal protein S6, mitochondrial OS=Mus musculus OX=10090 GN=Mrps6 PE=1 SV=3" 0.092 1.158 10 1 1 1 125 14.3 9.5 1 1 996940.375 994928.6875 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf01250 121022 ENSMUSG00000039680.9 Mrps6 16 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Medium A0A140T8P1 Immunoglobulin kappa variable 6-14 (Fragment) OS=Mus musculus OX=10090 GN=Igkv6-14 PE=4 SV=2 0.017 2.321 8 1 1 1 115 12.8 6.51 1 1 693708.6875 1247771.125 1 1 structural molecule activity "Pf00047, Pf01410, Pf07679, Pf07686" 667881 ENSMUSG00000096844.1 Igkv6-14 6 0 Medium Q9ESP1 Stromal cell-derived factor 2-like protein 1 OS=Mus musculus OX=10090 GN=Sdf2l1 PE=1 SV=2 0.028 1.756 9 1 1 1 221 23.6 7.42 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding Pf02815 64136 ENSMUSG00000022769.7 Sdf2l1 16 0 Medium A0A1L1STE6 "Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Mus musculus OX=10090 GN=Idh3a PE=1 SV=1" 0.023 1.927 3 1 1 1 384 41.5 6.93 1 1 385193.125 698553.75 1399532.25 1 1 1 metabolic process mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00180 ENSMUSG00000032279.11 9 0 High H9KV15 Protein SON OS=Mus musculus OX=10090 GN=Son PE=1 SV=1 0.003 3.676 1 1 1 1 2343 253.9 5.4 1 1 139993.7656 567413.625 605611.5625 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding 20658 ENSMUSG00000022961.17 Son 16 0 Low P30681 High mobility group protein B2 OS=Mus musculus OX=10090 GN=Hmgb2 PE=1 SV=3 0.071 1.329 6 1 1 1 210 24.1 7.31 1 1 148747.5469 591690 522551.3125 1 1 1 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;extracellular;nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf09011" 97165 ENSMUSG00000054717.7 Hmgb2 8 Activation of DNA fragmentation factor 0 Medium Q3UPW3 LIM domain only 7 (Fragment) OS=Mus musculus OX=10090 GN=Lmo7 PE=1 SV=1 0.028 1.763 1 1 1 1 471 55.1 8.88 1 1 80245.49219 307002.4063 1 1 metabolic process;regulation of biological process membrane catalytic activity;protein binding 380928 ENSMUSG00000033060.15 Lmo7 14 Neddylation; Antigen processing: Ubiquitination & Proteasome degradation 0 Low Q91ZR3 CREB/ATF bZIP transcription factor OS=Mus musculus OX=10090 GN=Crebzf PE=1 SV=2 0.061 1.384 2 1 1 1 358 37.8 5.86 1 1 404103.3438 888368.0625 1572730 1 1 1 metabolic process;regulation of biological process;response to stimulus mitochondrion;nucleus protein binding 233490 ENSMUSG00000051451.6 Crebzf 7 0 Medium Q9JLF6 Protein-glutamine gamma-glutamyltransferase K OS=Mus musculus OX=10090 GN=Tgm1 PE=1 SV=2 0.012 2.46 1 1 1 1 815 89.8 6.51 1 1 149739.5313 735225.75 1165041.25 1 1 1 cell differentiation;metabolic process;regulation of biological process membrane catalytic activity;metal ion binding "Pf00868, Pf00927, Pf01841" 21816 Tgm1 14 0 High D3YW09 Splicing factor 3A subunit 2 OS=Mus musculus OX=10090 GN=Sf3a2 PE=1 SV=1 0 6.228 7 1 1 1 194 22.1 9.42 1 1 1233062.5 1 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding Pf12874 20222 ENSMUSG00000020211.15 Sf3a2 10 mRNA Splicing - Major Pathway 0 Low J3QNP7 RIKEN cDNA 1700014D04 gene (Fragment) OS=Mus musculus OX=10090 GN=1700014D04Rik PE=4 SV=1 0.084 1.261 21 1 1 1 99 11.2 9.63 1 1 303231712 271188416 427266656 1 1 1 Pf14650 ENSMUSG00000051054.3 13 0 Low A2AGU5 Claudin 34D OS=Mus musculus OX=10090 GN=Cldn34d PE=4 SV=1 0.077 1.304 5 1 1 1 210 23.9 9.95 1 1 membrane structural molecule activity Pf13903 74987 ENSMUSG00000079525.1 4930468A15Rik; Cldn34d X Leukocyte transendothelial migration; Cell adhesion molecules (CAMs); Hepatitis C; Tight junction 0 Medium Q8R1B4 Eukaryotic translation initiation factor 3 subunit C OS=Mus musculus OX=10090 GN=Eif3c PE=1 SV=1 0.023 2.109 1 1 1 1 911 105.5 5.78 1 1 metabolic process;regulation of biological process cytoplasm protein binding;RNA binding "Pf01399, Pf05470" 56347 ENSMUSG00000030738.11 Eif3c 7 "Formation of a pool of free 40S subunits; L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit" RNA transport 0 High Q922U1 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Mus musculus OX=10090 GN=Prpf3 PE=1 SV=1 0.003 3.388 3 1 1 1 683 77.4 9.5 1 1 616164 415279.3438 1 1 cell organization and biogenesis;metabolic process cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf01480, Pf06544, Pf08572" 70767 ENSMUSG00000015748.13 Prpf3 3 mRNA Splicing - Major Pathway Spliceosome 0 Medium Q8BX10 "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Mus musculus OX=10090 GN=Pgam5 PE=1 SV=1" 0.028 1.678 3 1 1 1 288 32 9.04 1 1 720885.375 1168703.75 1 1 cell death;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding;signal transducer activity Pf00300 72542 ENSMUSG00000029500.16 Pgam5 5 Receptor Mediated Mitophagy TNF signaling pathway 0 Medium Q9JHQ0 Annexin A9 OS=Mus musculus OX=10090 GN=Anxa9 PE=2 SV=2 0.026 1.806 3 1 1 1 345 38.1 5.49 1 1 220138.8906 1 regulation of biological process;response to stimulus cell surface;cytosol metal ion binding;receptor activity;signal transducer activity Pf00191 71790 ENSMUSG00000015702.13 Anxa9 3 0 Medium P01725 Ig lambda-1 chain V region S178 OS=Mus musculus OX=10090 PE=1 SV=1 0.017 2.391 8 1 1 1 110 11.6 8 1 1 2091907.5 719688.1875 292303.3125 1 1 1 response to stimulus Pf07686 16142 Iglv1 16 0 High Q3UDC3 Target of Myb protein 1 OS=Mus musculus OX=10090 GN=Tom1 PE=1 SV=1 0.002 3.86 3 1 1 1 516 57.1 4.97 1 1 Acetyl [N-Term] transport cytoplasm;cytosol;endosome;membrane protein binding "Pf00790, Pf03127" 21968 ENSMUSG00000042870.15 Tom1 8 0 Medium Q9JIF7 Coatomer subunit beta OS=Mus musculus OX=10090 GN=Copb1 PE=1 SV=1 0.017 2.281 2 1 1 1 953 107 6 1 1 1338045.875 1 transport cytoplasm;cytosol;Golgi;membrane structural molecule activity "Pf01602, Pf07718, Pf14806" 70349 ENSMUSG00000030754.9 Copb1 7 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation 0 High Q9D8L3 "Signal sequence receptor, delta OS=Mus musculus OX=10090 GN=Ssr4 PE=1 SV=1" 0.01 2.778 6 1 1 1 173 19 5.78 1 1 endoplasmic reticulum;membrane Pf05404 20832 ENSMUSG00000002014.12 Ssr4 X 0 Low Q9Z222 "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 OS=Mus musculus OX=10090 GN=B3GNT2 PE=1 SV=3" 0.061 1.386 4 1 1 1 397 45.9 9.22 1 1 154317.8125 603309.25 1234231.875 1 1 1 cellular component movement;metabolic process Golgi;membrane catalytic activity "Pf01762, Pf02434, Pf04646" 53625 ENSMUSG00000051650.10 B3gnt2 11 O-linked glycosylation of mucins; Keratan sulfate biosynthesis Metabolic pathways; Glycosphingolipid biosynthesis - lacto and neolacto series; Glycosaminoglycan biosynthesis - keratan sulfate 0 Medium Q9CR39 WD repeat domain phosphoinositide-interacting protein 3 OS=Mus musculus OX=10090 GN=Wdr45b PE=1 SV=2 0.023 2.1 4 1 1 1 344 38 7.56 1 1 366070.375 1 metabolic process cytosol;membrane protein binding 66840 ENSMUSG00000025173.13 Wdr45b; Wdr45l 11 0 Medium P52955 Transcription factor LBX1 OS=Mus musculus OX=10090 GN=Lbx1 PE=1 SV=2 0.034 1.621 11 1 1 1 282 30.2 6.93 1 1 cell differentiation;development;metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf00046, Pf05920" 16814 ENSMUSG00000025216.9 Lbx1 19 0 High Q9DAW6 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Mus musculus OX=10090 GN=Prpf4 PE=1 SV=1 0.009 2.939 3 1 1 1 521 58.3 7.28 1 1 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00400, Pf08799" 70052 ENSMUSG00000066148.3 Prpf4 4 mRNA Splicing - Major Pathway Spliceosome 0 Medium Q9WUR0 Tubulo-interstitial nephritis antigen OS=Mus musculus OX=10090 GN=Tinag PE=1 SV=1 0.023 2.035 3 1 1 1 475 54.2 7.59 1 1 380419.9375 578751.3125 923657.625 1 1 1 metabolic process;response to stimulus;transport vacuole catalytic activity;receptor activity "Pf00112, Pf01033" 26944 ENSMUSG00000032357.12 Tinag 9 0 Medium A0A075B5S9 Immunoglobulin heavy variable 9-4 OS=Mus musculus OX=10090 GN=Ighv9-4 PE=4 SV=1 0.023 1.896 11 1 1 1 98 10.9 9.07 1 1 "Pf00047, Pf07686" ENSMUSG00000094322.2 12 0 High O70194 Eukaryotic translation initiation factor 3 subunit D OS=Mus musculus OX=10090 GN=Eif3d PE=1 SV=2 0.003 3.193 2 1 1 1 548 63.9 6.05 1 1 390322.3438 697232.5 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane RNA binding Pf05091 55944 ENSMUSG00000016554.8 Eif3d 15 "Formation of a pool of free 40S subunits; L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit" RNA transport 0 Low D3Z041 Long-chain-fatty-acid--CoA ligase 1 OS=Mus musculus OX=10090 GN=Acsl1 PE=1 SV=1 0.073 1.325 1 1 1 1 699 78 7.47 1 1 333444.375 368664.5938 1 1 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity Pf00501 ENSMUSG00000018796.13 8 0 High A0A2R8W6S4 Protein kinase C and casein kinase substrate in neurons protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Pacsin2 PE=1 SV=1 0.004 3.111 4 1 1 1 272 31.3 4.81 1 1 1146419.25 1635782.875 1 1 0 Medium Q9Z2I0 Mitochondrial proton/calcium exchanger protein OS=Mus musculus OX=10090 GN=Letm1 PE=1 SV=1 0.021 2.16 2 1 1 1 738 82.9 6.52 1 1 216554.2031 188500.375 646230.4375 1 1 1 cell organization and biogenesis;cellular homeostasis;transport membrane;mitochondrion metal ion binding;transporter activity Pf07766 56384 ENSMUSG00000005299.6 Letm1 5 0 Medium P56873 Protein ZNRD2 OS=Mus musculus OX=10090 GN=Znrd2 PE=1 SV=1 0.01 2.709 5 1 1 1 199 21.3 5.12 1 1 567892.9375 2152713.75 3377156.5 1 1 1 protein binding Pf06677 56390 ENSMUSG00000079478.8 Sssca1 19 0 Medium P35459 Lymphocyte antigen 6D OS=Mus musculus OX=10090 GN=Ly6d PE=1 SV=1 0.028 1.769 11 1 1 1 127 13.4 7.5 1 1 694087.3125 1 cell differentiation;response to stimulus cell surface;membrane Pf00021 17068 ENSMUSG00000034634.7 Ly6d 15 Post-translational modification: synthesis of GPI-anchored proteins 0 Medium Q9DCA2 "28S ribosomal protein S11, mitochondrial OS=Mus musculus OX=10090 GN=Mrps11 PE=1 SV=2" 0.023 1.905 5 1 1 1 191 20.2 10.77 1 1 640495.75 1124648.125 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00411 67994 Mrps11 7 0 Low A0A2I3BQB1 Vomeronasal type-1 receptor OS=Mus musculus OX=10090 GN=Vmn1r199 PE=3 SV=1 0.07 1.355 2 1 1 1 324 37 9.79 1 1 100530.375 1339884.125 2408169 1 1 1 0 High D3YVX4 Stromal membrane-associated protein 1 OS=Mus musculus OX=10090 GN=Smap1 PE=1 SV=1 0.002 4.294 4 1 1 1 355 37.8 8.13 1 1 557564 788486.6875 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;membrane enzyme regulator activity;metal ion binding;protein binding 98366 ENSMUSG00000026155.13 Smap1 1 0 Low A0A494B9Y4 Coronin (Fragment) OS=Mus musculus OX=10090 GN=Coro1b PE=1 SV=1 0.086 1.248 3 1 1 1 251 28 7.43 1 1 165369.0469 1 0 High Q9CZ44 NSFL1 cofactor p47 OS=Mus musculus OX=10090 GN=Nsfl1c PE=1 SV=1 0.006 2.99 3 1 1 1 370 40.7 5.15 1 1 381151.8438 362323.0625 1 1 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoskeleton;cytosol;Golgi;membrane;nucleus enzyme regulator activity;protein binding "Pf00789, Pf08059, Pf14555" 386649 ENSMUSG00000027455.16 Nsfl1c 2 Protein processing in endoplasmic reticulum 0 Low D3YUP5 Exocyst complex component 3-like 2 OS=Mus musculus OX=10090 GN=Exoc3l2 PE=1 SV=2 0.063 1.364 2 1 1 1 789 87.1 9.22 1 1 transport protein binding Pf06046 74463 ENSMUSG00000011263.16 Exoc3l2 7 0 High P42227 Signal transducer and activator of transcription 3 OS=Mus musculus OX=10090 GN=Stat3 PE=1 SV=2 0.004 3.004 2 1 1 1 770 88 6.3 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;reproduction;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus DNA binding;protein binding;signal transducer activity "Pf00017, Pf01017, Pf02864, Pf02865" 20848 ENSMUSG00000004040.16 Stat3 11 Signaling by Leptin; Interleukin-7 signaling; PTK6 Activates STAT3; Interleukin-35 Signalling; Signaling by SCF-KIT; Mus musculus biological processes; Interleukin-15 signaling; Interleukin-6 family signaling; Downstream signal transduction; Interleukin-4 and 13 signaling; Interleukin-10 signaling; Interleukin-20 family signaling; MET activates STAT3 FoxO signaling pathway; Acute myeloid leukemia; AGE-RAGE signaling pathway in diabetic complications; MicroRNAs in cancer; Prolactin signaling pathway; Jak-STAT signaling pathway; Toxoplasmosis; Epstein-Barr virus infection; Chemokine signaling pathway; Signaling pathways regulating pluripotency of stem cells; Insulin resistance; Hepatitis B; Inflammatory bowel disease (IBD); Proteoglycans in cancer; HIF-1 signaling pathway; Pathways in cancer; Hepatitis C; Adipocytokine signaling pathway; Pancreatic cancer; EGFR tyrosine kinase inhibitor resistance; Viral carcinogenesis; Measles 0 High P63030 Mitochondrial pyruvate carrier 1 OS=Mus musculus OX=10090 GN=Mpc1 PE=1 SV=1 0.003 3.239 24 1 1 1 109 12.4 9.61 1 1 71161.53906 2336106.75 3568287.5 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity "Pf01483, Pf03650" 55951 ENSMUSG00000023861.17 Mpc1 17 0 Low P70188 Kinesin-associated protein 3 OS=Mus musculus OX=10090 GN=Kifap3 PE=1 SV=1 0.054 1.41 2 1 1 1 793 91.2 5.11 1 1 regulation of biological process chromosome;cytoskeleton;cytosol;endoplasmic reticulum;Golgi protein binding Pf05804 16579 ENSMUSG00000026585.13 Kifap3 1 MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Intraflagellar transport; Kinesins 0 Low Q9CS72 Filamin-A-interacting protein 1 OS=Mus musculus OX=10090 GN=Filip1 PE=1 SV=2 0.087 1.216 1 1 1 1 1211 137.5 8.19 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;membrane "Pf04111, Pf04156, Pf04849, Pf06160, Pf08317, Pf09727, Pf09744, Pf09787, Pf12128" 70598 Filip1 9 0 Medium Q8BKF1 "DNA-directed RNA polymerase, mitochondrial OS=Mus musculus OX=10090 GN=Polrmt PE=1 SV=1" 0.023 2.093 2 1 1 1 1207 136.6 9.09 1 1 191336.4219 216019.7813 1 1 cell organization and biogenesis;metabolic process mitochondrion catalytic activity;DNA binding;RNA binding "Pf00940, Pf14700" 216151 ENSMUSG00000020329.12 Polrmt 10 Mitochondrial transcription initiation 0 High Q9ES74 Serine/threonine-protein kinase Nek7 OS=Mus musculus OX=10090 GN=Nek7 PE=1 SV=1 0.003 3.45 6 1 1 1 302 34.5 8.25 1 1 287942.375 486791.3125 1 1 metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714, Pf14531" 59125 ENSMUSG00000026393.10 Nek7 1 NOD-like receptor signaling pathway 0 Medium Q3TJD7 PDZ and LIM domain protein 7 OS=Mus musculus OX=10090 GN=Pdlim7 PE=1 SV=1 0.021 2.172 2 1 1 1 457 50.1 8.47 1 1 789016.8125 1 cell differentiation;cell organization and biogenesis;development;regulation of biological process cytoplasm;cytoskeleton;nucleus metal ion binding;protein binding "Pf00412, Pf00595" 67399 ENSMUSG00000021493.15 Pdlim7 13 RET signaling 0 Medium Q9Z1Q5 Chloride intracellular channel protein 1 OS=Mus musculus OX=10090 GN=Clic1 PE=1 SV=3 0.023 1.94 15 1 1 1 241 27 5.17 1 1 metabolic process;regulation of biological process;transport cytoplasm;membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity "Pf00043, Pf13409, Pf13410, Pf13417" 114584 ENSMUSG00000007041.9 Clic1 17 0 Low Q8JZQ9 Eukaryotic translation initiation factor 3 subunit B OS=Mus musculus OX=10090 GN=Eif3b PE=1 SV=1 0.088 1.22 1 1 1 1 803 91.3 5.02 1 1 232371.6719 401085.1875 1 1 metabolic process;regulation of biological process cytoplasm protein binding;RNA binding "Pf00076, Pf08662, Pf13893, Pf14259" 27979 ENSMUSG00000056076.13 Eif3b 5 "Formation of a pool of free 40S subunits; L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit" RNA transport 0 High P97352 Protein S100-A13 OS=Mus musculus OX=10090 GN=S100a13 PE=1 SV=1 0.004 3.101 11 1 1 1 98 11.2 6.13 1 1 regulation of biological process;transport cytoplasm;cytosol;extracellular;membrane;nucleus metal ion binding;protein binding Pf01023 20196 S100a13 3 0 High P70168 Importin subunit beta-1 OS=Mus musculus OX=10090 GN=Kpnb1 PE=1 SV=2 0.002 3.808 2 1 1 1 876 97.1 4.78 1 1 383667.375 779403.1875 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;transporter activity "Pf02985, Pf03810, Pf13513" 16211 ENSMUSG00000001440.5 Kpnb1 11 Activation of DNA fragmentation factor; Neutrophil degranulation; Regulation of cholesterol biosynthesis by SREBP (SREBF) RNA transport 0 Low P52792 Hexokinase-4 OS=Mus musculus OX=10090 GN=Gck PE=1 SV=1 0.084 1.256 3 1 1 1 465 52.1 5.29 1 1 1602747.625 1332270.625 1 1 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00349, Pf03727" 103988 ENSMUSG00000041798.15 Gck 11 Regulation of Glucokinase by Glucokinase Regulatory Protein "Neomycin, kanamycin and gentamicin biosynthesis; Type II diabetes mellitus; Prolactin signaling pathway; Insulin signaling pathway; Metabolic pathways; Maturity onset diabetes of the young; Amino sugar and nucleotide sugar metabolism; Starch and sucrose metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism; Insulin secretion; Galactose metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway" 0 High A0A1Y7VJH3 Apoptosis-stimulating of p53 protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Ppp1r13b PE=1 SV=1 0.009 2.934 1 1 1 1 964 104.4 7.23 1 1 cell death;regulation of biological process;response to stimulus protein binding "Pf00018, Pf00023, Pf02463, Pf07653, Pf10498, Pf11711, Pf12795, Pf12796, Pf13606, Pf13637, Pf13857, Pf13863, Pf14604, Pf15324" 0 Medium E9Q705 BolA-like protein 3 OS=Mus musculus OX=10090 GN=Bola3 PE=1 SV=1 0.023 1.915 7 1 1 1 95 10.8 8.31 1 1 116659.4844 562820.3125 951495.5 1 1 1 Pf01722 ENSMUSG00000045160.14 6 0 Medium Q01279 Epidermal growth factor receptor OS=Mus musculus OX=10090 GN=Egfr PE=1 SV=1 0.021 2.162 1 1 1 1 1210 134.8 6.86 1 1 1221633.625 2770787.5 3689878.25 1 1 1 cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane;nucleus;organelle lumen catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00069, Pf00757, Pf01030, Pf07714, Pf14843" 13649 ENSMUSG00000020122.16 Egfr 11 "EGFR interacts with phospholipase C-gamma; Downregulation of ERBB2 signaling; GAB1 signalosome; Signaling by GPCR; EGFR downregulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ERBB2 Regulates Cell Motility; SHC1 events in EGFR signaling; Interleukin-20 family signaling; Signaling by ERBB4; EGFR Transactivation by Gastrin; PI3K events in ERBB2 signaling; RAF/MAP kinase cascade; PTK6 promotes HIF1A stabilization; GRB2 events in EGFR signaling; ERBB2 Activates PTK6 Signaling; Signal transduction by L1; Cargo recognition for clathrin-mediated endocytosis; SHC1 events in ERBB2 signaling" Oxytocin signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Endocytosis; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; MicroRNAs in cancer; Ras signaling pathway; Focal adhesion; Endometrial cancer; Breast cancer; Melanoma; Non-small cell lung cancer; Adherens junction; Dorso-ventral axis formation; Proteoglycans in cancer; Rap1 signaling pathway; HIF-1 signaling pathway; Pathways in cancer; Calcium signaling pathway; Hepatitis C; Pancreatic cancer; PI3K-Akt signaling pathway; GnRH signaling pathway; Gap junction; Glioma; EGFR tyrosine kinase inhibitor resistance; Central carbon metabolism in cancer; Choline metabolism in cancer; Estrogen signaling pathway; Cytokine-cytokine receptor interaction; Prostate cancer; Endocrine resistance; Bladder cancer 0 Low O08804 NK13 OS=Mus musculus OX=10090 GN=Serpinb6b PE=1 SV=2 0.097 1.117 4 1 1 1 377 42.5 5.26 1 1 13795782 24079516 27449026 1 1 1 regulation of biological process cytoplasm enzyme regulator activity Pf00079 20708 ENSMUSG00000042842.10 Serpinb6b 13 Neutrophil degranulation Amoebiasis 0 High Q7M6Y3 Phosphatidylinositol-binding clathrin assembly protein OS=Mus musculus OX=10090 GN=Picalm PE=1 SV=1 0.002 4.523 5 1 1 1 660 71.5 7.91 1 1 791079.375 1 cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endosome;Golgi;membrane;nucleus protein binding "Pf01417, Pf07651" 233489 ENSMUSG00000039361.11 Picalm 7 Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis 0 Medium F6SQH7 Polymerase delta-interacting protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Poldip2 PE=1 SV=1 0.023 2.092 4 1 1 1 284 32.6 7.91 1 1 109966.6328 588297.4375 785595.3125 1 1 1 cell organization and biogenesis;regulation of biological process mitochondrion DNA binding "Pf04379, Pf08755" ENSMUSG00000001100.10 11 0 High Q8VC69 Solute carrier family 22 member 6 OS=Mus musculus OX=10090 GN=Slc22a6 PE=1 SV=1 0 4.947 2 1 1 1 545 60 9.1 1 1 827589.875 1610607.875 1 1 cell organization and biogenesis;response to stimulus;transport membrane protein binding;transporter activity "Pf00083, Pf07690" 18399 ENSMUSG00000024650.4 Slc22a6 19 Organic anion transport 0 Medium A0A075B664 Immunoglobulin lambda variable 2 OS=Mus musculus OX=10090 GN=Iglv2 PE=1 SV=1 0.023 2.107 8 1 1 1 116 12.2 5.74 1 1 2091907.5 719688.1875 292303.3125 1 1 1 Pf07686 ENSMUSG00000076940.3 16 0 High Q9D8W5 26S proteasome non-ATPase regulatory subunit 12 OS=Mus musculus OX=10090 GN=Psmd12 PE=1 SV=4 0.002 4.154 3 1 1 1 456 52.9 7.06 1 1 metabolic process cytoplasm;membrane;proteasome protein binding Pf01399 66997 ENSMUSG00000020720.13 Psmd12 11 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 Medium A0A140T8N8 Immunoglobulin kappa variable 9-123 (Fragment) OS=Mus musculus OX=10090 GN=Igkv9-123 PE=4 SV=2 0.023 1.941 14 1 1 1 117 12.8 6.54 1 1 1863697.25 1499714.25 1 1 "Pf00047, Pf07679, Pf07686" 628144 ENSMUSG00000076512.2 Igkv9-123 6 0 Low A0A3Q4EBZ6 WD repeat-containing protein 46 (Fragment) OS=Mus musculus OX=10090 GN=Wdr46 PE=1 SV=1 0.062 1.374 5 1 1 1 329 36.4 9.41 1 1 2099875.75 965633.5 1 1 0 Medium Q91VK2 Eef1d protein OS=Mus musculus OX=10090 GN=Eef1d PE=1 SV=1 0.026 1.843 4 1 1 1 276 30.6 4.98 1 1 423870.4375 788658.625 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus DNA binding;protein binding;RNA binding;signal transducer activity Pf00736 66656 ENSMUSG00000055762.15 Eef1d 15 Eukaryotic Translation Elongation 0 High A0A140LIS5 Arginine and glutamate-rich protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Arglu1 PE=1 SV=1 0.003 3.353 4 1 1 1 215 25.9 10.62 1 1 140231.6563 648878.4375 1076574 1 1 1 ENSMUSG00000040459.11 8 0 High P97807 "Fumarate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Fh PE=1 SV=3" 0.004 3.045 8 1 1 1 507 54.3 9.04 1 1 796647.5625 1 metabolic process cytoplasm;mitochondrion catalytic activity "Pf00206, Pf10415" 14194 ENSMUSG00000026526.14 Fh1 1 Citric acid cycle (TCA cycle) Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Pathways in cancer; Renal cell carcinoma; Carbon metabolism 0 Medium Q9DB15 "39S ribosomal protein L12, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl12 PE=1 SV=2" 0.01 2.716 6 1 1 1 201 21.7 9.29 1 1 167145.4375 458175.2188 860982.4375 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;ribosome structural molecule activity Pf00542 56282 ENSMUSG00000039640.7 Mrpl12 11 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High A0A1Y7VK55 Nuclear factor 1 OS=Mus musculus OX=10090 GN=Nfic PE=1 SV=1 0.009 2.899 2 1 1 1 461 51.3 8.31 1 1 110929.625 362129.0938 455838.4375 1 1 1 metabolic process;regulation of biological process nucleus DNA binding "Pf00859, Pf03165, Pf10524" 0 Medium Q62426 Cystatin-B OS=Mus musculus OX=10090 GN=Cstb PE=1 SV=1 0.01 2.531 21 1 1 1 98 11 7.39 1 1 245023.0156 1681411 794912.0625 1 1 1 regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus enzyme regulator activity;protein binding;RNA binding Pf00031 13014 ENSMUSG00000005054.7 Cstb 10 Neutrophil degranulation 0 Medium G5E850 Cytochrome b5 OS=Mus musculus OX=10090 GN=Cyb5a PE=1 SV=1 0.023 1.925 12 1 1 1 98 11.1 5.3 1 1 375468.0938 493396.375 1 1 metabolic process;transport cytosol;endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;protein binding Pf00173 109672 ENSMUSG00000024646.13 Cyb5; Cyb5a 18 0 High Q9ERS2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Mus musculus OX=10090 GN=Ndufa13 PE=1 SV=3 0.004 3.033 6 1 1 1 144 16.8 9.48 1 1 323981.875 1706802.625 1186905.25 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding Pf06212 67184 ENSMUSG00000036199.9 Ndufa13 8 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Medium P32921 "Tryptophan--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Wars1 PE=1 SV=2" 0.046 1.457 3 1 1 1 481 54.3 6.89 1 1 123467.5078 1109196.125 873447.875 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00458, Pf00579" 22375 ENSMUSG00000021266.16 Wars 12 Aminoacyl-tRNA biosynthesis 0 Medium Q9CW03 Structural maintenance of chromosomes protein 3 OS=Mus musculus OX=10090 GN=Smc3 PE=1 SV=2 0.048 1.45 1 1 1 1 1217 141.5 7.18 1 1 774904.375 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;nucleus nucleotide binding;protein binding;transporter activity "Pf01496, Pf02463, Pf04111, Pf06470, Pf10168, Pf12128, Pf13304, Pf13476, Pf13555" 13006 ENSMUSG00000024974.10 Smc3 19 Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Meiotic Synapsis; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Mus musculus biological processes; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 High Q99J99 3-mercaptopyruvate sulfurtransferase OS=Mus musculus OX=10090 GN=Mpst PE=1 SV=4 0.003 3.535 4 1 1 1 297 33.1 6.47 1 1 291008.0313 599270.0625 1 1 0 High F6TCV0 "Serine protease HTRA2, mitochondrial (Fragment) OS=Mus musculus OX=10090 GN=Htra2 PE=1 SV=1" 0.003 3.486 4 1 1 1 294 31.8 8.46 1 1 649970.6875 1008886.375 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus mitochondrion catalytic activity;protein binding "Pf00089, Pf00595, Pf04495, Pf10459, Pf13180, Pf13365" ENSMUSG00000068329.12 6 0 Medium Q9CQE3 "28S ribosomal protein S17, mitochondrial OS=Mus musculus OX=10090 GN=Mrps17 PE=1 SV=1" 0.017 2.403 20 1 1 1 120 13.4 9.89 1 1 1015368.188 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00366 66258 ENSMUSG00000034211.14 Mrps17 5 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Low H3BJU9 Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Mus musculus OX=10090 GN=Lrch4 PE=1 SV=1 0.058 1.402 12 1 1 1 139 14.5 9.5 1 1 regulation of biological process cytoplasm ENSMUSG00000093445.7 5 0 Medium Q8K4Z5 Splicing factor 3A subunit 1 OS=Mus musculus OX=10090 GN=Sf3a1 PE=1 SV=1 0.026 1.843 1 1 1 1 791 88.5 5.22 1 1 1781354.625 3610749 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00240, Pf01805, Pf12230, Pf14560" 67465 ENSMUSG00000002129.11 Sf3a1 11 mRNA Splicing - Major Pathway Spliceosome 0 Low J3QPZ9 Beta-enolase (Fragment) OS=Mus musculus OX=10090 GN=Eno3 PE=1 SV=1 0.072 1.321 8 1 1 1 190 20.6 5.11 1 1 1202696.125 1 metabolic process catalytic activity;metal ion binding "Pf00113, Pf13378" ENSMUSG00000060600.15 11 0 Medium Q62036 Centrosomal protein of 131 kDa OS=Mus musculus OX=10090 GN=Cep131 PE=1 SV=2 0.023 1.997 1 1 1 1 1060 120.2 8.72 1 1 812354.125 350877.2813 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton protein binding "Pf02463, Pf04111, Pf04156, Pf06785, Pf12325" 12009 ENSMUSG00000039781.14 Azi1; Cep131 11 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes 0 Low A0A0N4SWD9 Selenocysteine-specific elongation factor (Fragment) OS=Mus musculus OX=10090 GN=Eefsec PE=1 SV=1 0.084 1.259 5 1 1 1 242 26 8.94 1 1 65998.125 228076.5938 310654.7188 1 1 1 metabolic process;regulation of biological process mitochondrion catalytic activity;nucleotide binding;RNA binding Pf00009 ENSMUSG00000033216.9 6 0 Medium Q80UY2 E3 ubiquitin-protein ligase KCMF1 OS=Mus musculus OX=10090 GN=Kcmf1 PE=1 SV=1 0.024 1.849 4 1 1 1 381 41.8 5.76 1 1 239102.0781 1 metabolic process catalytic activity;metal ion binding "Pf00569, Pf05605" 74287 ENSMUSG00000055239.10 Kcmf1 6 Neutrophil degranulation 0 Low A0A087WPR7 Dystonin (Fragment) OS=Mus musculus OX=10090 GN=Dst PE=1 SV=1 0.062 1.369 0 1 1 1 2987 331.3 4.94 1 1 2438886 6031188.5 1 1 cell organization and biogenesis cytoskeleton protein binding "Pf00435, Pf00681" ENSMUSG00000026131.18 1 0 High O35343 Importin subunit alpha-3 OS=Mus musculus OX=10090 GN=Kpna4 PE=1 SV=1 0 6.132 3 1 1 1 521 57.9 4.94 1 1 199059.4375 1 response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;transporter activity "Pf00514, Pf01602, Pf01749, Pf13513, Pf13646" 16649 ENSMUSG00000027782.10 Kpna4 3 0 Low E9Q5L3 "Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadsb PE=1 SV=1" 0.102 1.068 3 1 1 1 465 51.8 8.32 1 1 960241.625 1 metabolic process membrane catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" ENSMUSG00000030861.15 7 0 Low I7HPW1 Bromodomain containing 2 (Fragment) OS=Mus musculus OX=10090 GN=Brd2 PE=1 SV=1 0.07 1.331 2 1 1 1 473 52.2 9.52 1 1 1416578.875 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding Pf00439 14312 ENSMUSG00000024335.19 Brd2 17 0 High P54729 NEDD8 ultimate buster 1 OS=Mus musculus OX=10090 GN=Nub1 PE=1 SV=2 0.009 2.929 1 1 1 1 614 70.3 5.88 1 1 466186.6563 1 metabolic process;regulation of biological process cytosol;nucleus protein binding Pf00627 53312 ENSMUSG00000028954.11 Nub1 5 0 Low F8VPU2 "FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Mus musculus OX=10090 GN=Farp1 PE=1 SV=1" 0.075 1.31 1 1 1 1 1048 118.8 7.88 1 1 114446.4219 293798.7188 1 1 cell organization and biogenesis;development;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane protein binding "Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380" 223254 ENSMUSG00000025555.14 Farp1 14 0 Medium Q8CAK1 "Putative transferase CAF17 homolog, mitochondrial OS=Mus musculus OX=10090 GN=Iba57 PE=1 SV=1" 0.016 2.425 4 1 1 1 358 38.4 9.01 1 1 365437.0313 1 cell organization and biogenesis;metabolic process mitochondrion;organelle lumen catalytic activity;RNA binding "Pf01571, Pf08669" 216792 ENSMUSG00000049287.5 Iba57 11 0 High B1ARS0 Adenylyl cyclase-associated protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Cap1 PE=1 SV=1 0 6 12 1 1 1 164 17.9 6.38 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane protein binding Pf01213 12331 ENSMUSG00000028656.14 Cap1 4 0 Medium Q3ZAR9 Nr2c2 protein OS=Mus musculus OX=10090 GN=Nr2c2 PE=1 SV=1 0.049 1.444 4 1 1 1 501 54.6 6.83 1 1 79927.21875 225708.9531 1222852.75 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00104, Pf00105" 22026 ENSMUSG00000005893.14 Nr2c2 6 0 Medium A0A286YD02 Phosphodiesterase OS=Mus musculus OX=10090 GN=Pde4c PE=1 SV=1 0.018 2.25 2 1 1 1 646 72.3 5.08 1 1 86532.35938 192880.5313 241285.0156 1 1 1 0 Medium E9Q8I9 Protein furry homolog OS=Mus musculus OX=10090 GN=Fry PE=1 SV=1 0.046 1.46 0 1 1 1 3020 338.9 6.01 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton enzyme regulator activity "Pf14222, Pf14225, Pf14228" 320365 ENSMUSG00000056602.11 Fry 5 0 High D3Z6A1 Dynactin subunit 6 (Fragment) OS=Mus musculus OX=10090 GN=Dctn6 PE=1 SV=1 0.002 3.905 14 1 1 1 103 11.2 5.16 1 1 ENSMUSG00000031516.11 8 0 Medium Q9ERA0 Alpha-globin transcription factor CP2 OS=Mus musculus OX=10090 GN=Tfcp2 PE=1 SV=1 0.023 2.042 8 1 1 1 502 57 5.54 1 1 metabolic process;regulation of biological process cytosol;nucleus DNA binding;protein binding Pf04516 21422 ENSMUSG00000009733.8 Tfcp2 15 0 Medium Q6QI06 Rapamycin-insensitive companion of mTOR OS=Mus musculus OX=10090 GN=Rictor PE=1 SV=2 0.01 2.616 0 1 1 1 1708 191.4 7.23 1 1 51653.875 457629.9688 1 1 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus enzyme regulator activity;protein binding "Pf14663, Pf14664, Pf14665, Pf14666, Pf14668" 78757 ENSMUSG00000050310.8 Rictor 15 PIP3 activates AKT signaling; VEGFR2 mediated vascular permeability; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation mTOR signaling pathway 0 Medium Q8C0P0 Serine/threonine-protein kinase greatwall OS=Mus musculus OX=10090 GN=Mastl PE=2 SV=2 0.035 1.592 2 1 1 1 865 95.9 5.57 1 1 429600.3125 519922.1563 1837009.375 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 67121 ENSMUSG00000026779.6 Mastl 2 MASTL Facilitates Mitotic Progression 0 High Q8R5H1 Ubiquitin carboxyl-terminal hydrolase 15 OS=Mus musculus OX=10090 GN=Usp15 PE=1 SV=1 0 9.997 2 1 1 1 981 112.3 5.17 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding "Pf00443, Pf06337, Pf13423, Pf14533, Pf14836" 14479 ENSMUSG00000020124.10 Usp15 10 Ub-specific processing proteases 0 Low Q8R404 MICOS complex subunit MIC13 OS=Mus musculus OX=10090 GN=Micos13 PE=1 SV=1 0.082 1.286 6 1 1 1 119 13.4 8.63 1 1 156840.375 1258469.875 1 1 cell organization and biogenesis membrane;mitochondrion 224904 ENSMUSG00000049760.5 2410015M20Rik 17 0 Medium Q792Z1 Trypsin 10 OS=Mus musculus OX=10090 GN=Try10 PE=1 SV=1 0.017 2.402 4 1 1 1 246 26.2 5.83 1 1 579894.5625 1283741.375 1 1 metabolic process catalytic activity Pf00089 436522 ENSMUSG00000071521.4 Try10 6 "Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation; Collagen degradation; Antimicrobial peptides; Activation of Matrix Metalloproteinases" Pancreatic secretion; Protein digestion and absorption; Influenza A; Neuroactive ligand-receptor interaction 0 High B1ARW4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Fragment) OS=Mus musculus OX=10090 GN=Ndufs5 PE=1 SV=1 0.002 3.902 14 1 1 1 91 10.9 8.94 1 1 187440.2188 367225.8438 484448.7188 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion "Pf08583, Pf10200" 595136 ENSMUSG00000028648.13 Ndufs5 4 0 High P35564 Calnexin OS=Mus musculus OX=10090 GN=Canx PE=1 SV=1 0.003 3.724 3 1 1 1 591 67.2 4.64 1 1 metabolic process;transport cytoplasm;endoplasmic reticulum;membrane;ribosome metal ion binding;protein binding;RNA binding Pf00262 12330 ENSMUSG00000020368.15 Canx 11 "Calnexin/calreticulin cycle; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; Interleukin-35 Signalling" HTLV-I infection; Thyroid hormone synthesis; Phagosome; Antigen processing and presentation; Protein processing in endoplasmic reticulum 0 Medium A0A5F8MQ17 Aquaporin-4 OS=Mus musculus OX=10090 GN=Aqp4 PE=1 SV=1 0.027 1.836 8 1 1 1 330 35.3 5.8 1 1 0 Low Q9EP93 Vomeronasal type-1 receptor 53 OS=Mus musculus OX=10090 GN=Vmn1r53 PE=2 SV=1 0.084 1.268 2 1 1 1 310 35.4 9.61 1 1 140447.375 566386.5 551639.5 1 1 1 regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity Pf03402 113853 Vmn1r53 6 0 High A0A0R3P9C8 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Mus musculus OX=10090 GN=Ndufa9 PE=1 SV=1" 0.003 3.207 4 1 1 1 373 42.1 9.09 1 1 296229.125 557685.125 895670.5625 1 1 1 metabolic process membrane;mitochondrion catalytic activity "Pf01073, Pf01370, Pf05368, Pf13460" ENSMUSG00000000399.10 6 0 High E9PW20 Chromatin target of PRMT1 protein OS=Mus musculus OX=10090 GN=Chtop PE=1 SV=1 0.003 3.421 6 1 1 1 203 22.1 11.97 1 1 848754.125 1 metabolic process;regulation of biological process nucleus protein binding;RNA binding Pf13865 66511 ENSMUSG00000001017.15 Chtop 3 0 Medium Q8CHD8 Rab11 family-interacting protein 3 OS=Mus musculus OX=10090 GN=Rab11fip3 PE=1 SV=2 0.01 2.603 1 1 1 1 1047 118.5 4.39 1 1 587559.6875 1 cell division;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;endosome;membrane catalytic activity;enzyme regulator activity;metal ion binding;motor activity;nucleotide binding;protein binding "Pf00769, Pf01025, Pf01576, Pf02463, Pf02841, Pf03234, Pf03961, Pf04012, Pf04111, Pf04156, Pf04849, Pf05557, Pf05700, Pf06818, Pf07888, Pf09457, Pf09726, Pf09744, Pf10186, Pf12128, Pf13405, Pf13499, Pf13868, Pf15558" 215445 ENSMUSG00000037098.17 Rab11fip3 17 VxPx cargo-targeting to cilium Endocytosis 0 High Q91YQ5 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Mus musculus OX=10090 GN=Rpn1 PE=1 SV=1 0.003 3.407 3 1 1 1 608 68.5 6.46 1 1 207225.25 725315.125 1442009.5 1 1 1 metabolic process cytosol;endoplasmic reticulum;membrane catalytic activity;RNA binding Pf04597 103963 ENSMUSG00000030062.7 Rpn1 6 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 Low P35550 rRNA 2'-O-methyltransferase fibrillarin OS=Mus musculus OX=10090 GN=Fbl PE=1 SV=2 0.084 1.256 6 1 1 1 327 34.3 10.24 1 1 cell differentiation;cell organization and biogenesis;metabolic process chromosome;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf01135, Pf01269, Pf13847" 14113; 102643269 ENSMUSG00000046865.7 LOC100044829; Fbl; LOC102643269 7; 3 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High P08905 Lysozyme C-2 OS=Mus musculus OX=10090 GN=Lyz2 PE=1 SV=2 0 5.412 10 1 1 1 148 16.7 8.81 1 1 defense response;metabolic process;response to stimulus cytoplasm;extracellular;organelle lumen catalytic activity;protein binding "Pf00062, Pf01464" 17105 ENSMUSG00000069516.8 Lyz2 10 Neutrophil degranulation; Antimicrobial peptides Salivary secretion 0 Medium O89113 Immediate early response gene 5 protein OS=Mus musculus OX=10090 GN=Ier5 PE=2 SV=1 0.023 1.988 3 1 1 1 308 31.8 5.43 1 1 251014.2656 928283.375 897737.3125 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding Pf05760 15939 ENSMUSG00000056708.5 Ier5 1 0 Medium A0A338P7B7 Dynein light chain Tctex-type 1A OS=Mus musculus OX=10090 GN=Dynlt1a PE=1 SV=1 0.035 1.585 14 1 1 1 112 12.2 5.12 1 1 54864008 62010820 58413192 1 1 1 0 Medium P01637 Ig kappa chain V-V region T1 OS=Mus musculus OX=10090 PE=4 SV=1 0.027 1.704 12 1 1 1 128 14.4 8.59 1 1 315365.0625 394304.5 1 1 "Pf00047, Pf07679, Pf07686" 545847 Igkv14-111 6 0 Medium D3YXK2 Scaffold attachment factor B1 OS=Mus musculus OX=10090 GN=Safb PE=1 SV=2 0.01 2.693 1 1 1 1 937 105 5.35 1 1 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 224903 ENSMUSG00000071054.12 Safb 17 0 High P01132 Pro-epidermal growth factor OS=Mus musculus OX=10090 GN=Egf PE=1 SV=2 0.004 3.033 2 1 1 1 1217 133 6.46 1 1 311305.25 1 metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00008, Pf00058, Pf07645, Pf12662, Pf12947, Pf14670" 13645 ENSMUSG00000028017.7 Egf 3 "EGFR interacts with phospholipase C-gamma; Downregulation of ERBB2 signaling; GAB1 signalosome; EGFR downregulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ERBB2 Regulates Cell Motility; SHC1 events in EGFR signaling; Interleukin-20 family signaling; Signaling by ERBB4; PI3K events in ERBB2 signaling; RAF/MAP kinase cascade; GRB2 events in EGFR signaling; ERBB2 Activates PTK6 Signaling; Platelet degranulation ; Cargo recognition for clathrin-mediated endocytosis; SHC1 events in ERBB2 signaling" ErbB signaling pathway; FoxO signaling pathway; Endocytosis; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Ras signaling pathway; Focal adhesion; Endometrial cancer; Breast cancer; Melanoma; Non-small cell lung cancer; Rap1 signaling pathway; HIF-1 signaling pathway; Pathways in cancer; Hepatitis C; Pancreatic cancer; PI3K-Akt signaling pathway; Gap junction; Glioma; EGFR tyrosine kinase inhibitor resistance; Choline metabolism in cancer; Cytokine-cytokine receptor interaction; Prostate cancer; Bladder cancer 0 Medium G3X9Y4 Rho-related GTP-binding protein RhoD OS=Mus musculus OX=10090 GN=Rhod PE=1 SV=1 0.028 1.677 4 1 1 1 200 22.3 9.04 1 1 302854.2813 1374673 2411211.5 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endosome;membrane catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf04670, Pf08477" 11854 ENSMUSG00000041845.10 Rhod 19 0 High Q9CQ54 NADH dehydrogenase [ubiquinone] 1 subunit C2 OS=Mus musculus OX=10090 GN=Ndufc2 PE=1 SV=1 0.003 3.433 11 1 1 1 120 14.2 9.2 1 1 129389.875 646067.125 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;membrane;mitochondrion catalytic activity Pf06374 68197; 102641347 ENSMUSG00000030647.8 Ndufc2; LOC102641347 7; 15 Neutrophil degranulation; Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High D3Z276 RIKEN cDNA 2410002F23 gene (Fragment) OS=Mus musculus OX=10090 GN=2410002F23Rik PE=1 SV=7 0.002 4.323 20 1 1 1 156 17.9 5 1 1 1905641.25 1 ENSMUSG00000045411.16 7 0 Low A0A0R4J166 Kelch-like protein 40 OS=Mus musculus OX=10090 GN=Klhl40 PE=1 SV=1 0.087 1.208 1 1 1 1 621 69.6 5.17 1 1 296676.9375 645439.875 1 1 cell differentiation;development;regulation of biological process cytoplasm catalytic activity;protein binding "Pf00651, Pf01344, Pf07707, Pf13415, Pf13418, Pf13964" 72330 ENSMUSG00000074001.3 Kbtbd5; Klhl40 9 0 Low K7N5V5 Predicted gene 5862 OS=Mus musculus OX=10090 GN=Gm5862 PE=4 SV=1 0.092 1.169 4 1 1 1 267 31.6 6.48 1 1 Pf04822 545739; 75657 ENSMUSG00000067700.5 Gm5862; Speer4a 5 0 Medium Q6ZPG2 WD repeat-containing protein 90 OS=Mus musculus OX=10090 GN=Wdr90 PE=1 SV=2 0.018 2.263 1 1 1 1 1874 202.8 6.65 1 1 protein binding "Pf00400, Pf05018" 106618 ENSMUSG00000073434.11 Wdr90 17 0 High P34914 Bifunctional epoxide hydrolase 2 OS=Mus musculus OX=10090 GN=Ephx2 PE=1 SV=2 0.002 4.459 4 1 1 1 554 62.5 6.19 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;metal ion binding;protein binding "Pf00561, Pf00702, Pf12146, Pf12695, Pf12697, Pf13242, Pf13419" 13850 ENSMUSG00000022040.7 Ephx2 14 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Metabolic pathways; Arachidonic acid metabolism; Peroxisome 0 Low Q9R1Q9 V-type proton ATPase subunit S1 OS=Mus musculus OX=10090 GN=Atp6ap1 PE=1 SV=1 0.058 1.401 2 1 1 1 463 51 5.92 1 1 288496 1002186.938 317063.6875 1 1 1 cell death;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;transporter activity Pf05827 54411 ENSMUSG00000019087.13 Atp6ap1 X Ion channel transport; Transferrin endocytosis and recycling; Insulin receptor recycling Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Hepatitis B; Lysosome; Phagosome; Oxidative phosphorylation 0 Low E9Q8T1 Transforming acidic coiled-coil-containing protein 2 OS=Mus musculus OX=10090 GN=Tacc2 PE=1 SV=1 0.088 1.203 0 1 1 1 2879 305 4.79 1 1 1937446.25 1227444.5 766503.0625 1 1 1 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;protein binding "Pf01576, Pf02463, Pf05010, Pf05816, Pf06160, Pf07926, Pf08598, Pf09728, Pf09731, Pf12037, Pf12128, Pf13851, Pf13863, Pf13868, Pf15272, Pf15346" 57752 ENSMUSG00000030852.17 Tacc2 7 0 Medium Q8R2Q8 Bone marrow stromal antigen 2 OS=Mus musculus OX=10090 GN=Bst2 PE=1 SV=1 0.023 2.058 5 1 1 1 172 19.1 7.34 1 1 817008.875 564169.75 1185998.375 1 1 1 defense response;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;endosome;Golgi;membrane enzyme regulator activity;protein binding;RNA binding;signal transducer activity "Pf04849, Pf14193" 69550 ENSMUSG00000046718.8 Bst2 8 Neutrophil degranulation 0 Medium Q8VDM6 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Mus musculus OX=10090 GN=Hnrnpul1 PE=1 SV=1 0.013 2.443 2 1 1 1 859 95.9 6.58 1 1 558345.625 899905.75 1340547.875 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf13671" 232989 ENSMUSG00000040725.13 Hnrnpul1 7 mRNA Splicing - Major Pathway Influenza A 0 Medium A0A338P731 40S ribosomal protein S10 (Fragment) OS=Mus musculus OX=10090 GN=Rps10 PE=1 SV=1 0.025 1.84 7 1 1 1 107 12.8 10.04 1 1 2182914.5 1 0 Low Q8BXK8 "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Agap1 PE=1 SV=1" 0.054 1.424 2 1 1 1 857 94.4 7.94 1 1 261477.5625 846263.9375 1286283.75 1 1 1 Met-loss [N-Term] regulation of biological process;response to stimulus;transport cytoplasm;cytosol catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00023, Pf00071, Pf00169, Pf01412, Pf08477, Pf12796, Pf13606, Pf13637, Pf13857" 347722 ENSMUSG00000055013.15 Agap1 1 Endocytosis 0 Medium P47199 Quinone oxidoreductase OS=Mus musculus OX=10090 GN=Cryz PE=1 SV=1 0.024 1.849 7 1 1 1 331 35.2 8.07 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol catalytic activity;metal ion binding;nucleotide binding;RNA binding "Pf00107, Pf08240, Pf13602" 12972 ENSMUSG00000028199.18 Cryz 3 0 Low A2AGT5 Cytoskeleton-associated protein 5 OS=Mus musculus OX=10090 GN=Ckap5 PE=1 SV=1 0.092 1.171 0 1 1 1 2032 225.5 7.96 1 1 831465.6875 1 cell division;cell organization and biogenesis;transport chromosome;cytoplasm;cytoskeleton;membrane protein binding 75786 Ckap5 2 0 Medium Q4FE56 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus OX=10090 GN=Usp9x PE=1 SV=1 0.01 2.502 1 1 1 1 2554 290 5.83 1 1 cell division;cell growth;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;protein binding "Pf00443, Pf13423" 22284 ENSMUSG00000031010.17 Usp9x X Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0 High Q9R0E1 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Mus musculus OX=10090 GN=Plod3 PE=1 SV=1 0.004 3.053 2 1 1 1 741 84.9 6.23 1 1 cell organization and biogenesis;metabolic process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding Pf03171 26433 ENSMUSG00000004846.10 Plod3 5 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 0 High Q6P5E4 UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4 0 6.922 2 1 1 1 1551 176.3 5.62 1 1 755787.125 1721635.625 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen catalytic activity;protein binding Pf06427 320011 ENSMUSG00000037470.14 Uggt1 1 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0