Protein FDR Confidence: Combined Accession Description Exp. q-value: Combined Sum PEP Score Coverage [%] # Peptides # PSMs # Unique Peptides # AAs MW [kDa] calc. pI # Peptides (by Search Engine): A2 Sequest HT (IgG 293) # Peptides (by Search Engine): B2 Sequest HT (Sel1L 293) # Peptides (by Search Engine): C2 Sequest HT (WT 293) # Peptides (by Search Engine): D2 Sequest HT (HKO 293) # PSMs (by Search Engine): A2 Sequest HT (IgG 293) # PSMs (by Search Engine): B2 Sequest HT (Sel1L 293) # PSMs (by Search Engine): C2 Sequest HT (WT 293) # PSMs (by Search Engine): D2 Sequest HT (HKO 293) "Abundance: F1: Sample, IgG 293" "Abundance: F2: Sample, Sel1L 293" "Abundance: F3: Sample, WT 293" "Abundance: F4: Sample, HKO 293" "Abundances Count: F1: Sample, IgG 293" "Abundances Count: F2: Sample, Sel1L 293" "Abundances Count: F3: Sample, WT 293" "Abundances Count: F4: Sample, HKO 293" Modifications Biological Process Cellular Component Molecular Function Pfam IDs Entrez Gene ID Ensembl Gene ID Gene Symbol Chromosome Reactome Pathways KEGG Pathways # Razor Peptides High P14625 Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1 0 514.927 72 67 875 65 803 92.4 4.84 7 11 48 67 7 14 127 727 32098669.84 53609871.32 777174233 6838075776 35 37 66 89 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 7184 ENSG00000166598.14 HSP90B1 12 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ATF6 (ATF6-alpha) activates chaperone genes; Interleukin-4 and 13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Estrogen signaling pathway; PI3K-Akt signaling pathway 4 High Q9UBV2 Protein sel-1 homolog 1 OS=Homo sapiens OX=9606 GN=SEL1L PE=1 SV=3 0 653.833 71 41 843 41 794 88.7 5.39 1 39 34 1 341 501 80296095.73 82131041.82 4238481889 4506704296 8 15 68 61 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding "Pf00040, Pf08238" 6400 ENSG00000071537.13 SEL1L 14 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; Pre-NOTCH Processing in Golgi; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High P04264 "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" 0 351.627 72 50 670 44 644 66 8.12 41 39 42 40 183 167 162 158 1264623836 1379974142 1485372681 1530425919 66 62 65 56 cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;protein binding;receptor activity;structural molecule activity "Pf00038, Pf01576, Pf05103, Pf05957, Pf12128, Pf13166, Pf13514" 3848 ENSG00000167768.4 KRT1 12 Formation of the cornified envelope; Neutrophil degranulation 7 High Q96PY6 Serine/threonine-protein kinase Nek1 OS=Homo sapiens OX=9606 GN=NEK1 PE=1 SV=2 0 500.252 61 74 589 74 1258 142.7 5.94 72 64 55 234 181 174 6578498.125 1716026495 1144457276 1015927054 14 81 78 76 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 4750 ENSG00000137601.16 NEK1 4 0 High Q13438 Protein OS-9 OS=Homo sapiens OX=9606 GN=OS9 PE=1 SV=1 0 542.147 72 59 542 59 667 75.5 4.87 56 56 241 301 5121220.865 13912130.47 2381805764 4362208391 10 10 70 70 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane;organelle lumen protein binding Pf07915 10956 ENSG00000135506.15 OS9 12 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High O75592 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4 0 608.986 39 150 521 150 4678 513.3 7.02 1 110 122 102 1 164 204 152 12279883.7 388027417.3 462755909.3 350305066 32 148 145 130 0 High P27694 Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2 0 402.66 70 40 482 40 616 68.1 7.21 5 38 36 34 5 183 149 145 56081282.62 1948507468 1337273421 1133107301 17 50 52 53 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;metal ion binding;protein binding "Pf01336, Pf01485, Pf04057, Pf08646" 6117 ENSG00000132383.11 RPA1 17 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand; SUMOylation of DNA damage response and repair proteins Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High P35527 "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" 0 413.45 79 39 479 38 623 62 5.24 36 37 34 33 116 126 120 117 748440507.1 923383700.5 791001785.6 647796336.8 52 53 51 50 cell death;cell organization and biogenesis cytosol;membrane;nucleus structural molecule activity "Pf00038, Pf13166" 3857 ENSG00000171403.9 KRT9 17 Formation of the cornified envelope 1 High P13645 "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" 0 308.982 59 34 456 28 584 58.8 5.21 32 28 29 34 119 95 111 131 949534630.3 658257640.8 930682782.8 1184150717 45 44 46 47 cell death;cell differentiation;metabolic process cytoplasm;cytoskeleton;cytosol;membrane;nucleus structural molecule activity "Pf00038, Pf04111" 3858 ENSG00000186395.7 KRT10 17 Formation of the cornified envelope Staphylococcus aureus infection 8 High Q96DZ1 Endoplasmic reticulum lectin 1 OS=Homo sapiens OX=9606 GN=ERLEC1 PE=1 SV=1 0 375.463 87 38 387 38 483 54.8 6.28 37 32 217 170 428382.9688 992309.5234 2522615822 1402188348 1 3 47 44 metabolic process;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 27248 ENSG00000068912.13 ERLEC1 2 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High P35908 "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" 0 237.588 69 44 382 33 639 65.4 8 37 32 31 34 110 88 82 102 569002144.8 516561354.3 610456100.2 773566953.8 44 41 43 43 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process cytoskeleton;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf08614, Pf12128, Pf13166" 3849 ENSG00000172867.3 KRT2 12 Formation of the cornified envelope 8 High P11021 Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2 0 293.269 63 50 374 48 654 72.3 5.16 30 45 34 45 49 117 58 150 1205954763 1522830962 1624800027 2438400432 44 50 41 53 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00012, Pf01968, Pf06723" 3309 ENSG00000044574.7 HSPA5 9 "Platelet degranulation ; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response; IRE1alpha activates chaperones" Prion diseases; Protein export; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Antigen processing and presentation 3 High P19474 E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1 0 194.402 62 32 312 32 475 54.1 6.38 27 26 29 28 60 61 100 91 186064714.7 264246743.9 604023596 484896321.2 33 35 36 35 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus;vacuole catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00097, Pf00622, Pf00643, Pf11789, Pf12128, Pf12678, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227" 6737 ENSG00000132109.9 TRIM21 11 STING mediated induction of host immune responses; Antigen processing: Ubiquitination & Proteasome degradation; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA Systemic lupus erythematosus 0 High P35637 RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1 0 162.217 24 13 283 11 526 53.4 9.36 11 12 13 12 80 68 71 64 427647316.8 438031640.8 503446334 302386920.3 21 19 20 20 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" 2521 ENSG00000089280.18 FUS 16 mRNA Splicing - Major Pathway Transcriptional misregulation in cancer 2 High O43790 "Keratin, type II cuticular Hb6 OS=Homo sapiens OX=9606 GN=KRT86 PE=1 SV=1" 0 299.195 89 53 272 6 486 53.5 5.66 3 53 3 269 38770285.7 33555624 3905336300 63375156.3 14 6 57 6 cell death;regulation of biological process;transport cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf05557, Pf07888, Pf07926, Pf09726, Pf11559, Pf12128, Pf13166" 3892 ENSG00000170442.11 KRT86 12 Formation of the cornified envelope 50 High P11142 Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1 0 196.602 45 29 256 16 646 70.9 5.52 25 28 27 23 53 69 69 65 129192078 257196943.4 235306823.4 193412609.7 35 37 33 32 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00012, Pf02463, Pf06723" 3312 ENSG00000109971.13 HSPA8 11 "Protein methylation; Clathrin-mediated endocytosis; Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; Lysosome Vesicle Biogenesis; CHL1 interactions; AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; mRNA Splicing - Major Pathway; Interleukin-4 and 13 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR)" Endocytosis; Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 13 High P27708 CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3 0 250.264 34 54 224 54 2225 242.8 6.46 14 35 45 38 21 59 79 65 24095452.49 142140929.6 217266244.2 149578465 29 45 49 43 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00117, Pf00185, Pf00289, Pf00988, Pf01979, Pf02142, Pf02222, Pf02729, Pf02786, Pf02787, Pf07478, Pf07722, Pf13147, Pf13535, Pf13594, Pf15632" 790 ENSG00000084774.13 CAD 2 Pyrimidine biosynthesis "Alanine, aspartate and glutamate metabolism; Metabolic pathways; Pyrimidine metabolism" 0 High Q9H792 Inactive tyrosine-protein kinase PEAK1 OS=Homo sapiens OX=9606 GN=PEAK1 PE=1 SV=4 0 289.991 44 63 221 63 1746 193 6.89 58 42 29 113 62 46 2906985.949 341978947.8 131911934.7 96817638.55 9 57 51 51 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process cytoplasm;cytoskeleton catalytic activity;nucleotide binding;protein binding Pf00069 79834 ENSG00000173517.10 PEAK1 15 0 High Q96F24 Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1 0 181.268 72 24 216 24 287 32.4 5.87 23 18 15 132 45 39 51998199.42 970356814.2 213065590.4 193770274.6 3 30 23 28 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;vacuole DNA binding;protein binding "Pf02183, Pf04212, Pf04977, Pf08961" 29982 ENSG00000148572.15 NRBF2 10 Nuclear Receptor transcription pathway 0 High Q99570 Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3 0 281.819 42 47 212 47 1358 153 7.17 45 27 29 115 48 49 1566304.055 405542258.1 97351305.91 88982000.63 5 45 40 35 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00069, Pf00400" 30849 ENSG00000196455.7 PIK3R4 3 PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy Autophagy 0 High P0DMV9 Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1 0 149.196 51 29 210 25 641 70 5.66 23 23 28 26 49 47 54 60 113235310.8 115784425 200721672.9 178614014.4 24 22 25 26 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;receptor activity;RNA binding "Pf00012, Pf06723" 3304; 3303 ENSG00000232804.5; ENSG00000234475.5; ENSG00000231555.4; ENSG00000235941.5; ENSG00000204389.9; ENSG00000204388.6; ENSG00000212866.6; ENSG00000237724.5; ENSG00000224501.5 HSPA1B; HSPA1A 6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1 AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; Viral RNP Complexes in the Host Cell Nucleus; HSP90 chaperone cycle for steroid hormone receptors (SHR) Endocytosis; Longevity regulating pathway - multiple species; Prion diseases; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 0 High P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2 0 228.973 75 31 202 27 353 37.4 8.95 23 29 28 23 45 63 56 38 202524249.3 430310576.8 427476937.8 176749623.1 33 36 36 28 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3181 ENSG00000122566.20 HNRNPA2B1 7 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway 4 High P35244 Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1 0 124.53 88 8 183 8 121 13.6 5.08 1 8 8 6 1 54 50 78 1863853.332 267860394.7 232831246.3 186363605.6 6 15 15 12 Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding Pf08661 6119 ENSG00000106399.11 RPA3 7 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High Q13428 Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3 0 210.378 31 45 178 45 1488 152 9.04 36 37 29 61 64 53 29443493.91 283154362.8 251868122.8 251949535.2 12 44 43 41 cell organization and biogenesis;regulation of biological process;transport cytosol;nucleus protein binding;RNA binding;transporter activity Pf03546 6949 ENSG00000070814.17 TCOF1 5 Ribosome biogenesis in eukaryotes 0 High Q00839 Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6 0 152.928 36 30 177 30 825 90.5 6 16 21 26 22 25 47 61 44 67692703.9 141344093.8 215840202 115352123.3 31 34 35 27 cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;nucleotide binding;protein binding;RNA binding "Pf00622, Pf13671" 3192 ENSG00000153187.18 HNRNPU 1 mRNA Splicing - Major Pathway Spliceosome 0 High Q14533 "Keratin, type II cuticular Hb1 OS=Homo sapiens OX=9606 GN=KRT81 PE=1 SV=3" 0 234.413 77 47 175 3 505 54.9 5.47 2 47 2 173 104682960.5 3 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell death;transport cytosol protein binding;structural molecule activity "Pf00038, Pf07888, Pf07926, Pf11559" 3887 ENSG00000205426.10 KRT81 12 Formation of the cornified envelope 0 High Q9UQ35 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2 0 141.231 15 32 175 32 2752 299.4 12.06 20 23 25 23 34 52 51 38 70999208.27 99945402.34 104407104.1 72017178.19 28 29 27 24 metabolic process nucleus;spliceosomal complex nucleotide binding;protein binding;RNA binding 23524 ENSG00000167978.16 SRRM2 16 mRNA Splicing - Major Pathway 0 High P07437 Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2 0 147.674 65 22 174 3 444 49.6 4.89 8 19 19 18 13 48 52 61 32865171.73 134841323 112898993.4 118519221.7 22 28 28 25 cell division;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;extracellular;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 203068 ENSG00000232575.10; ENSG00000196230.12; ENSG00000227739.10; ENSG00000224156.10; ENSG00000235067.10; ENSG00000229684.10; ENSG00000183311.16; ENSG00000232421.10 TUBB 6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1 Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes Pathogenic Escherichia coli infection; Gap junction; Phagosome 26 High Q9UPQ9 Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4 0 219.045 41 45 174 45 1833 193.9 6.76 30 38 21 25 46 65 28 35 81199009.03 128942512.2 49602886.59 49301682.52 42 42 35 35 regulation of biological process;response to stimulus cytoplasm;cytosol protein binding;RNA binding "Pf10427, Pf13893" 23112 ENSG00000100354.20 TNRC6B 22 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High P78385 "Keratin, type II cuticular Hb3 OS=Homo sapiens OX=9606 GN=KRT83 PE=1 SV=2" 0 224.837 76 46 167 5 493 54.2 5.64 2 46 2 165 114087263.5 6 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell death;regulation of biological process;transport cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf05557, Pf05911, Pf07888, Pf07926, Pf09726, Pf10174, Pf11559, Pf12128, Pf13166" 3889 ENSG00000170523.3 KRT83 12 Formation of the cornified envelope 0 High P68371 Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1 0 134.909 55 20 167 1 445 49.8 4.89 10 18 18 16 18 47 51 51 42095254.38 852176921.8 328463760.5 438324287.6 2 3 3 3 cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 10383 ENSG00000188229.5 TUBB4B 9 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 1 High P78386 "Keratin, type II cuticular Hb5 OS=Homo sapiens OX=9606 GN=KRT85 PE=1 SV=1" 0 242.641 80 50 164 19 507 55.8 6.55 2 50 2 162 1204203.156 339692.0938 1020753479 234102.2969 4 1 24 1 cell death cytosol structural molecule activity "Pf00038, Pf09726" 3891 ENSG00000135443.8 KRT85 12 Formation of the cornified envelope 7 High Q9BQE3 Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1 0 117.42 44 17 155 5 449 49.9 5.1 8 15 15 17 18 45 45 47 13230211.28 60535939.63 51050492.31 77823799.63 3 5 5 4 cell division;cell organization and biogenesis;transport cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" 84790 ENSG00000167553.15 TUBA1C 12 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis 0 High P09651 Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5 0 153.923 59 24 151 20 372 38.7 9.13 19 22 22 11 36 42 53 20 83913514.45 134529188.6 163689812.4 56060554.28 21 20 21 13 cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3178 ENSG00000135486.17 HNRNPA1 12 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1 0 154.587 45 39 150 39 887 101.5 6.81 37 19 19 87 32 31 3223468.867 284432846.8 68397753.15 58656366.33 6 39 35 29 cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00454, Pf00613, Pf00792" 5289 ENSG00000078142.12 PIK3C3 18 PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy Phosphatidylinositol signaling system; Tuberculosis; Inositol phosphate metabolism; Phagosome; Autophagy; Metabolic pathways 0 High P15927 Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1 0 169.267 74 13 150 13 270 29.2 6.15 1 13 11 10 1 55 42 52 4511513.391 712376613.4 475714813 384004705.1 7 21 21 22 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf08784 6118 ENSG00000117748.9 RPA2 1 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair 0 High Q15323 "Keratin, type I cuticular Ha1 OS=Homo sapiens OX=9606 GN=KRT31 PE=1 SV=3" 0 198.824 74 36 145 8 416 47.2 4.88 2 1 36 1 5 3 134 3 74124630.53 53637858.75 2224659876 98289316.48 13 5 43 5 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis cytosol protein binding;structural molecule activity "Pf00038, Pf04156, Pf13514, Pf14362, Pf14643" 3881 ENSG00000094796.4; ENSG00000262993.1 KRT31 17; CHR_HSCHR17_1_CTG4 Formation of the cornified envelope 34 High P13647 "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" 0 101.123 47 32 143 18 590 62.3 7.74 24 22 26 23 36 30 40 37 57472216.88 70908100.34 87167262.97 91857054.59 23 24 24 21 cell death;cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf02994, Pf03961, Pf04111, Pf05957, Pf12128" 3852 ENSG00000186081.11 KRT5 12 Formation of the cornified envelope; Type I hemidesmosome assembly 5 High O14497 AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3 0 176.433 26 36 140 36 2285 241.9 6.7 23 29 25 19 37 38 40 25 42014724.44 46871541.75 43939063.09 23847198.98 30 30 29 20 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus DNA binding;protein binding "Pf01388, Pf12031" 8289 ENSG00000117713.18 ARID1A 1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High O43822 Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1 0 83.269 69 16 140 16 256 28.3 7.34 14 15 11 58 43 39 1146600.352 925793536.4 367051958.6 346913220.3 4 16 15 15 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion protein binding "Pf12799, Pf13855, Pf14580" 755 ENSG00000160226.15 C21orf2 21 0 High P68366 Tubulin alpha-4A chain OS=Homo sapiens OX=9606 GN=TUBA4A PE=1 SV=1 0 116.336 43 17 140 5 448 49.9 5.06 7 13 15 14 16 41 45 38 20447187.08 100156375.3 87821883.94 81175401.75 15 20 20 17 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" 7277 ENSG00000127824.13 TUBA4A 2 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis 16 High P15924 Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3 0 189.038 28 75 139 75 2871 331.6 6.81 24 15 68 10 26 17 86 10 35887297.05 25142631.61 137044273.5 12926957.62 50 43 66 28 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity "Pf00038, Pf00681, Pf01540, Pf01576, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06008, Pf06160, Pf06637, Pf07888, Pf10174, Pf12072, Pf12128, Pf13166" 1832 ENSG00000096696.13 DSP 6 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0 High P04350 Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2 0 105.941 57 19 136 2 444 49.6 4.88 6 16 15 13 13 35 45 43 1561086.063 525354.125 2 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 10382 ENSG00000104833.11 TUBB4A 19 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 0 High Q13616 Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2 0 150.027 47 34 132 34 776 89.6 8 29 28 24 44 45 43 625077.9375 111698650.7 105307828.9 85546999.39 2 31 32 31 cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol catalytic activity;protein binding "Pf00888, Pf10557" 8454 ENSG00000055130.15 CUL1 7 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Herpes simplex infection; Cell cycle 0 High Q13885 Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1 0 125.352 46 19 130 3 445 49.9 4.89 5 13 17 14 7 34 43 46 2210811.25 1036864.719 3691701.75 2365390.563 1 2 3 2 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 7280 ENSG00000137267.5 TUBB2A 6 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 0 High Q14525 "Keratin, type I cuticular Ha3-II OS=Homo sapiens OX=9606 GN=KRT33B PE=1 SV=3" 0 188.029 77 32 129 8 404 46.2 4.84 2 1 32 1 5 3 118 3 94689798.5 7 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell death;transport cytosol;membrane catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00529, Pf01576, Pf04156, Pf13514, Pf14362" 3884 ENSG00000263012.1; ENSG00000131738.10 KRT33B 17; CHR_HSCHR17_1_CTG4 Formation of the cornified envelope 0 High P02533 "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" 0 101.47 60 25 128 9 472 51.5 5.16 17 17 23 18 30 31 37 30 43502623.56 51482222.73 83477833.19 47897723.78 19 21 21 20 cell death;cell differentiation;cell organization and biogenesis;response to stimulus cytoplasm;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 3861 ENSG00000186847.5 KRT14 17 Formation of the cornified envelope; Type I hemidesmosome assembly 12 High P22061 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4 0 113.647 62 14 128 14 227 24.6 7.21 12 11 12 13 36 24 27 41 130349402 93215121.69 120638480.2 114596886.7 16 16 15 16 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf01135, Pf01209, Pf05175, Pf06325, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847" 5110 PCMT1 6 Protein repair 0 High Q5BKY9 Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1 0 51.441 29 9 116 9 247 28.4 10.02 8 9 9 8 31 25 27 33 280762198.2 270641837.1 244536955.4 200245581.9 10 11 9 8 RNA binding 257415 ENSG00000234545.7 FAM133B 7 0 High P68104 Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1 0 71.431 53 16 111 16 462 50.1 9.01 10 9 12 15 24 26 25 36 94661804.56 129733575.5 156796500.7 199302471.6 12 11 12 12 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 1915 ENSG00000156508.17 EEF1A1 6 Peptide chain elongation; Protein methylation; Neutrophil degranulation; HSF1 activation RNA transport; Legionellosis 0 High Q5UIP0 Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2 0 219.337 24 48 111 48 2472 274.3 5.52 26 33 33 29 40 42 971112.0723 53172350.63 77672686.28 74334280.8 7 42 44 45 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;membrane;nucleus protein binding Pf12231 55183 ENSG00000080345.17 RIF1 2 Nonhomologous End-Joining (NHEJ) Signaling pathways regulating pluripotency of stem cells 0 High O76009 "Keratin, type I cuticular Ha3-I OS=Homo sapiens OX=9606 GN=KRT33A PE=2 SV=2" 0 171.731 73 33 109 6 404 45.9 4.82 33 109 456121.25 256721874.2 2 11 Met-loss+Acetyl [N-Term] cell death;metabolic process cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf04156, Pf07888, Pf12128, Pf13166, Pf13514, Pf14362" 3883 ENSG00000006059.3; ENSG00000261986.1 KRT33A 17; CHR_HSCHR17_1_CTG4 Formation of the cornified envelope 5 High Q9UJV9 Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2 0 84.836 50 29 107 29 622 69.8 6.84 20 24 18 10 30 39 25 13 58743108.89 94300561.91 54771689.63 43529835.76 28 28 27 21 Acetyl [N-Term] cell death;cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf13307" 51428 ENSG00000183258.11 DDX41 5 IRF3-mediated induction of type I IFN; Regulation of innate immune responses to cytosolic DNA 0 High P02538 "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" 0 90.504 45 27 106 3 564 60 8 15 19 22 19 21 23 33 29 7300401.148 14811937.97 37137241.05 13596211.5 12 10 13 10 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf04111, Pf13166" 3853 ENSG00000205420.10 KRT6A 12 Formation of the cornified envelope 9 High P63261 "Actin, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=ACTG1 PE=1 SV=1" 0 88.293 55 15 106 1 375 41.8 5.48 9 13 13 14 19 25 33 29 2223655.5 1697390.359 2800995.406 657568.7734 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus nucleotide binding;protein binding;structural molecule activity Pf00022 71 ENSG00000184009.9 ACTG1 17 Signaling by BRAF and RAF fusions; Formation of annular gap junctions; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Clathrin-mediated endocytosis; Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; RHO GTPases activate IQGAPs; Signaling by RAS mutants; Recycling pathway of L1; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Translocation of GLUT4 to the plasma membrane; Adherens junctions interactions; EPH-ephrin mediated repulsion of cells; Paradoxical activation of RAF signaling by kinase inactive BRAF; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate Formins; Interleukin-20 family signaling Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis 0 High P62258 14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1 0 96.688 64 18 105 15 255 29.2 4.74 1 17 14 12 1 44 29 31 5040079.488 293764726.7 200993001.5 166569746.1 9 19 19 16 Acetyl [N-Term] cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding;RNA binding Pf00244 7531 ENSG00000108953.16; ENSG00000274474.3 YWHAE 17; CHR_HSCHR17_2_CTG2 Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; NADE modulates death signalling; Translocation of GLUT4 to the plasma membrane; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by Hippo; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of HSF1-mediated heat shock response; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; RAB GEFs exchange GTP for GDP on RABs; HSF1 activation; TP53 Regulates Metabolic Genes; Signalling by NGF; RHO GTPases activate PKNs Viral carcinogenesis; Epstein-Barr virus infection; Neurotrophin signaling pathway; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 4 High P04259 "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" 0 79.713 41 25 104 1 564 60 8 15 17 20 19 22 23 31 28 717321.8125 2070458.75 1024034 1 1 1 cell death;cell organization and biogenesis;metabolic process cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf13166" 3854 ENSG00000185479.5 KRT6B 12 Formation of the cornified envelope 0 High P51610 Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2 0 110.5 21 31 103 31 2035 208.6 7.46 21 25 17 33 41 29 168144533.9 204350590.1 198400590.3 276637915.7 11 27 29 25 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;protein binding "Pf01344, Pf13415, Pf13418, Pf13854, Pf13964" 3054 ENSG00000172534.13 HCFC1 X Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones; UCH proteinases Herpes simplex infection 0 High P08779 "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" 0 82.823 57 24 101 11 473 51.2 5.05 14 13 23 15 19 20 39 23 6469124.719 6151850.703 20281522.28 6085903.281 7 7 9 6 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;regulation of biological process;response to stimulus cytoskeleton;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf07888, Pf13514" 3868 ENSG00000186832.8 KRT16 17 Formation of the cornified envelope 0 High Q92974 Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4 0 111.482 38 33 101 33 986 111.5 7.27 1 27 25 20 1 37 35 28 1486375.477 69787488.69 69785262.25 49119851.16 6 28 28 24 cell division;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane metal ion binding;protein binding "Pf00130, Pf00169, Pf00621, Pf07649" 9181 ENSG00000116584.17 ARHGEF2 1 G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle Pathogenic Escherichia coli infection 0 High P12956 X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2 0 121.886 45 26 100 26 609 69.8 6.64 23 16 19 43 27 30 1215978.03 62043805.67 43489822.41 40495266.57 9 24 27 25 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf02037, Pf02735, Pf03730, Pf03731" 2547 ENSG00000196419.12 XRCC6 22 2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P60709 "Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1" 0 86.393 55 15 100 1 375 41.7 5.48 8 13 13 13 17 23 32 28 42349549.5 80762889.78 118428937.8 80048850.19 17 18 20 16 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;nucleotide binding;protein binding;structural molecule activity Pf00022 60 ENSG00000075624.13 ACTB 7 Formation of annular gap junctions; Cell-extracellular matrix interactions; UCH proteinases; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; Factors involved in megakaryocyte development and platelet production; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Prefoldin mediated transfer of substrate to CCT/TriC; EPHB-mediated forward signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Folding of actin by CCT/TriC; DNA Damage Recognition in GG-NER; Regulation of actin dynamics for phagocytic cup formation; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Clathrin-mediated endocytosis; VEGFA-VEGFR2 Pathway; HATs acetylate histones; RHO GTPases activate IQGAPs; Recycling pathway of L1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Adherens junctions interactions; RHO GTPases Activate WASPs and WAVEs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Gastric acid secretion; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis 18 High Q7Z794 "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3" 0 19.731 10 7 99 3 578 61.9 5.99 4 3 4 5 29 22 20 28 85540969.34 91808215.69 99027138.41 101981913.3 2 2 3 3 cell death;cell organization and biogenesis cytoskeleton;cytosol structural molecule activity "Pf00038, Pf03962, Pf13166, Pf14817" 374454 ENSG00000189182.9 KRT77 12 Formation of the cornified envelope 0 High O76011 "Keratin, type I cuticular Ha4 OS=Homo sapiens OX=9606 GN=KRT34 PE=1 SV=2" 0 169.527 71 31 97 17 436 49.4 5.06 31 97 6350680.313 6128735.25 173940346.9 590224.1875 6 2 18 1 cell death;metabolic process cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf04156, Pf07888, Pf12128, Pf13514" 3885; 100653049 ENSG00000131737.5 KRT34; LOC100653049 17 Formation of the cornified envelope 0 High O95714 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2 0 154.623 15 58 95 58 4834 526.9 6.28 5 56 5 12 5 73 5 12 15225610.41 93770863.75 19786920.29 16394983.72 28 46 28 31 metabolic process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00173, Pf00415, Pf00569, Pf00632, Pf03256, Pf06701, Pf11515, Pf13540" 8924 ENSG00000128731.15 HERC2 15 G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Antigen processing: Ubiquitination & Proteasome degradation; SUMOylation of DNA damage response and repair proteins Ubiquitin mediated proteolysis 0 High P38646 "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" 0 118.996 38 25 95 24 679 73.6 6.16 12 16 20 13 20 25 31 19 48059670.34 76653084.31 83617034.66 52163667.03 20 23 23 23 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;mitochondrion;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00012, Pf06723" 3313 ENSG00000113013.12 HSPA9 5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Interleukin-12 family signaling; Cristae formation; Metabolism of proteins Tuberculosis; RNA degradation 0 High Q15424 Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4 0 105.367 22 18 94 10 915 102.6 5.47 16 14 13 9 26 25 26 17 48565188.19 52392527.94 56399963.73 40586612.08 17 16 16 15 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 6294 ENSG00000160633.12 SAFB 19 8 High Q9NVI7 ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2 0 80.906 43 24 94 9 634 71.3 8.98 12 5 18 21 18 6 22 48 29623819.69 15655605.81 54076730.56 78977830 16 15 19 22 Met-loss+Acetyl [N-Term] cell growth;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401" 55210 ENSG00000197785.13 ATAD3A 1 14 High P54652 Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1 0 72.898 19 13 89 1 639 70 5.74 9 11 11 9 18 23 23 25 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus nucleotide binding;protein binding "Pf00012, Pf06723" 3306 ENSG00000126803.9 HSPA2 14 Meiotic synapsis; Attenuation phase; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of HSF1-mediated heat shock response Endocytosis; Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation 0 High P51991 Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2 0 93.62 52 22 89 21 378 39.6 9.01 14 16 14 8 18 31 27 13 49371778.66 93357668.56 80991774.59 36526365.25 18 20 19 12 Acetyl [N-Term] metabolic process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding;transporter activity "Pf00076, Pf13893, Pf14259" 220988 ENSG00000170144.20 HNRNPA3 2 mRNA Splicing - Major Pathway Spliceosome 0 High Q9Y383 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2 0 66.622 44 17 88 11 392 46.5 10.01 13 12 12 13 20 19 21 28 50786538.11 55347583.38 74921056.89 58277043.44 18 18 18 14 Met-loss+Acetyl [N-Term] cell organization and biogenesis nucleus;spliceosomal complex protein binding;RNA binding Pf03194 51631 ENSG00000146963.17 LUC7L2 7 6 High P05141 ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7 0 45.026 50 16 88 4 298 32.8 9.69 7 5 12 15 13 7 25 43 21272544.22 22393528.84 147081537.8 349055941.9 11 12 13 17 Met-loss+Acetyl [N-Term] regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;RNA binding;transporter activity Pf00153 292 ENSG00000005022.5 SLC25A5 X Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Regulation of insulin secretion cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 13 High Q92764 "Keratin, type I cuticular Ha5 OS=Homo sapiens OX=9606 GN=KRT35 PE=1 SV=5" 0 157.148 65 28 86 17 455 50.3 4.91 1 1 28 1 4 3 76 3 1188167.625 860264.6875 163950546.8 1544014.266 3 3 25 4 cell death cytosol structural molecule activity Pf00038 3886 ENSG00000197079.8 KRT35 17 Formation of the cornified envelope 6 High O00571 ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3 0 83.62 42 23 85 22 662 73.2 7.18 19 16 19 11 23 20 28 14 31762332.89 35218587.95 42411607.78 33496045.25 24 23 25 20 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 1654 ENSG00000215301.9 DDX3X X Neutrophil degranulation Viral carcinogenesis; Hepatitis B; RIG-I-like receptor signaling pathway 2 High P31943 Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4 0 89.822 42 13 84 7 449 49.2 6.3 11 12 12 7 23 23 26 12 45890644.69 60258319.38 81126582.25 45931485.56 16 13 15 14 Met-loss [N-Term]; Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3187 ENSG00000169045.17; ENSG00000284254.1 HNRNPH1 5; CHR_HG30_PATCH mRNA Splicing - Major Pathway; FGFR2 alternative splicing 9 High P19338 Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3 0 80.954 32 19 84 19 710 76.6 4.7 12 18 17 11 17 28 24 15 25948118.78 48985321.5 50629062.78 38972309.81 15 18 18 15 regulation of biological process;response to stimulus cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 4691 ENSG00000115053.15 NCL 2 Major pathway of rRNA processing in the nucleolus and cytosol Pathogenic Escherichia coli infection 0 High Q92922 SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3 0 90.814 25 19 83 13 1105 122.8 5.76 14 17 10 9 24 28 15 16 30524595.67 35066142.44 24371366.31 20474165.9 21 20 17 17 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding Pf04433 6599 ENSG00000173473.10 SMARCC1 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 7 High O95625 Zinc finger and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ZBTB11 PE=1 SV=2 0 97.103 29 25 82 25 1053 119.3 8.66 22 21 14 33 29 20 253568.1016 55665686.72 70373246.69 35804222.16 2 21 22 18 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00651, Pf13465" 27107 ENSG00000066422.4 ZBTB11 3 0 High Q06830 Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1 0 44.76 61 13 79 12 199 22.1 8.13 11 11 12 12 19 20 22 18 46643739.34 66978224.84 74734798.25 67041499.91 13 13 13 13 cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00578, Pf08534, Pf10417" 5052 ENSG00000117450.13 PRDX1 1 TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species Peroxisome 1 High Q5T9A4 ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1 0 62.045 32 20 79 5 648 72.5 9.2 10 3 15 16 17 4 18 40 7257415.969 2345228.672 8179778.281 12172454.19 4 2 5 4 Met-loss+Acetyl [N-Term] transport membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf07726, Pf07728, Pf12037, Pf13207, Pf13401" 83858 ENSG00000160072.19 ATAD3B 1 Neutrophil degranulation 0 High Q9NSB4 "Keratin, type II cuticular Hb2 OS=Homo sapiens OX=9606 GN=KRT82 PE=1 SV=3" 0 133.927 65 34 78 28 513 56.6 6.74 1 33 2 1 75 2 20585738.66 20609299.17 291214321.9 35303558.39 2 3 29 3 Met-loss+Acetyl [N-Term] cell death cytosol structural molecule activity Pf00038 3888 ENSG00000161850.2 KRT82 12 Formation of the cornified envelope 0 High P13646 "Keratin, type I cytoskeletal 13 OS=Homo sapiens OX=9606 GN=KRT13 PE=1 SV=4" 0 34.275 18 10 77 2 458 49.6 4.96 6 6 8 6 20 15 22 20 468003.8125 1341253.75 1 1 cell death;cell organization and biogenesis;response to stimulus cytoskeleton;cytosol;nucleus protein binding;structural molecule activity Pf00038 3860 ENSG00000171401.14 KRT13 17 Formation of the cornified envelope 0 High Q66PJ3 ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=2 0 58.574 24 10 76 10 421 44.9 10.93 9 9 10 9 18 21 19 18 97582119.31 164210194.1 89556265.22 76745995.94 11 11 11 11 metabolic process nucleus protein binding;RNA binding Pf10500 51329 ENSG00000182196.13 ARL6IP4 12 0 High Q5VT25 Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1 0 106.771 22 32 75 32 1732 197.2 6.58 1 23 20 16 1 31 25 18 4608944.25 51332607.19 42516337.17 30053031.88 3 28 27 21 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;extracellular;Golgi catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00769, Pf00780, Pf01442, Pf01576, Pf02463, Pf03999, Pf04012, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06160, Pf06785, Pf07714, Pf07888, Pf08317, Pf08826, Pf09726, Pf09730, Pf09755, Pf10174, Pf10498, Pf12037, Pf12128, Pf12718, Pf12795, Pf13514, Pf13851, Pf13868, Pf14362, Pf14531, Pf14915, Pf15558, Pf15619" 8476 ENSG00000143776.18 CDC42BPA 1 0 High Q9BUJ2 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2 0 80.907 28 19 75 19 856 95.7 6.92 13 12 15 10 20 18 22 15 19501699.67 24465041.33 29443692.33 18454460.75 17 19 17 15 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf13671" 11100 ENSG00000105323.16 HNRNPUL1 19 mRNA Splicing - Major Pathway Influenza A 0 High P09874 Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4 0 98.026 36 29 73 29 1014 113 8.88 25 16 13 39 18 16 1156335.594 67074854.75 25242911.59 23070183.34 7 26 24 22 Met-loss+Acetyl [N-Term] cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063" 142 ENSG00000143799.12 PARP1 1 POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); SUMOylation of DNA damage response and repair proteins Base excision repair; NF-kappa B signaling pathway; Apoptosis 0 High Q96DT7 Zinc finger and BTB domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZBTB10 PE=1 SV=2 0 83.785 29 15 73 15 871 94.8 5.16 13 15 14 22 24 27 913283.0469 39980004.17 45976727.36 40091060.25 3 15 15 16 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 65986 ENSG00000205189.11 ZBTB10 8 0 High P62701 "40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" 0 57.417 62 17 72 17 263 29.6 10.15 10 16 14 12 14 22 19 17 24436280 70978914.09 55889135.86 43248845.56 18 18 18 18 cell organization and biogenesis;development;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00900, Pf08071" 6191 ENSG00000198034.10 RPS4X X "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q8TA86 Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2 0 32.196 46 9 72 9 221 26.1 9.79 7 5 8 8 17 17 18 20 183195875.7 172300900.8 142579869.3 223587011.1 11 11 11 11 Met-loss+Acetyl [N-Term] metabolic process cytosol;nucleus metal ion binding;protein binding;RNA binding 6100 ENSG00000164610.8 RP9 7 Spliceosome 0 High Q14532 "Keratin, type I cuticular Ha2 OS=Homo sapiens OX=9606 GN=KRT32 PE=1 SV=3" 0 118.202 51 21 72 11 448 50.3 4.84 1 1 21 1 4 3 62 3 506043.6094 171885037 1804202.781 2 16 3 cell death;cell organization and biogenesis cytoskeleton;cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf05287, Pf06160, Pf12128, Pf13514" 3882 ENSG00000108759.3 KRT32 17 Formation of the cornified envelope 2 High P68133 "Actin, alpha skeletal muscle OS=Homo sapiens OX=9606 GN=ACTA1 PE=1 SV=1" 0 41.891 34 11 71 2 377 42 5.39 7 8 9 9 14 15 23 19 2258827.5 2631179.938 4235926 2172178 2 2 2 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;structural molecule activity Pf00022 58 ENSG00000143632.14 ACTA1 1 Striated Muscle Contraction 0 High P12236 ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4 0 36.888 51 15 70 2 298 32.8 9.74 5 3 10 13 9 5 19 37 691143.125 370269.5938 4232127.75 12525143.44 2 1 3 4 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 293 ENSG00000169100.13 SLC25A6 X|Y; X Mitochondrial protein import; Regulation of insulin secretion; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Influenza Virus Induced Apoptosis; Metabolism of proteins cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway 2 High P11940 Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2 0 65.837 40 20 70 14 636 70.6 9.5 18 12 13 9 23 16 19 12 39882546.59 27842613.06 31521451.25 13872340.81 18 16 17 14 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding;translation regulator activity "Pf00076, Pf00658, Pf13893, Pf14259" 26986 ENSG00000070756.15 PABPC1 8 AUF1 (hnRNP D0) binds and destabilizes mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA RNA degradation; mRNA surveillance pathway; RNA transport 5 High O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3 0 103.408 29 27 68 27 1046 116.9 6.7 15 21 20 15 28 25 1111381.258 26813782.17 41945974.25 38623250.81 6 22 23 21 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf00515, Pf04184, Pf07719, Pf13176, Pf13181, Pf13374, Pf13414, Pf13424, Pf13428, Pf13429, Pf13431, Pf13432, Pf13844, Pf14559" 8473 ENSG00000147162.13 OGT X HATs acetylate histones; UCH proteinases Other types of O-glycan biosynthesis; Insulin resistance 0 High P08238 Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4 0 75.022 25 17 68 8 724 83.2 5.03 8 6 12 13 10 6 23 29 9549911.797 19914458.03 32686579.72 35148563.44 14 14 15 15 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 3326 ENSG00000096384.19 HSP90AB1 6 Sema3A PAK dependent Axon repulsion; HSF1 activation; Attenuation phase; Neutrophil degranulation; Aryl hydrocarbon receptor signalling; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation 7 High Q14151 Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1 0 76.909 16 13 67 5 953 107.4 6.16 9 7 10 9 18 15 19 15 1816197.172 4213803.813 2965678.281 3450831.563 3 4 4 5 cell differentiation;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 9667 ENSG00000130254.11 SAFB2 19 0 High P13010 X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3 0 97.935 35 22 65 22 732 82.7 5.81 16 17 15 23 22 20 1817585.484 32571855.41 27598857.75 28771093.56 6 20 19 16 cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf02735, Pf03730, Pf03731, Pf08785" 7520 ENSG00000079246.15 XRCC5 2 2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ) Non-homologous end-joining 0 High P07237 Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3 0 97.622 59 28 65 28 508 57.1 4.87 3 28 8 8 4 43 10 8 7947693.398 108653684.6 21140674.25 16937876.55 15 27 21 18 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13899, Pf13905" 5034 ENSG00000185624.14 P4HB 17 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); VLDL assembly; Chylomicron assembly; Collagen biosynthesis and modifying enzymes; Interleukin-12 family signaling; Detoxification of Reactive Oxygen Species; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum 0 High Q9BYQ3 Keratin-associated protein 9-3 OS=Homo sapiens OX=9606 GN=KRTAP9-3 PE=1 SV=1 0 98.229 45 4 63 3 159 16.8 7.53 4 63 239702371.3 7 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 83900 ENSG00000262749.2; ENSG00000204873.4 KRTAP9-3 17; CHR_HSCHR17_5_CTG4 Keratinization 0 High P62424 60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2 0 58.351 50 18 63 18 266 30 10.61 10 14 14 9 13 18 19 13 29622142.75 55669811.19 56294919.47 40423382.19 15 17 16 16 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01248 6130 ENSG00000280858.2; ENSG00000148303.16 RPL7A 9; CHR_HG2030_PATCH Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P35658 Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2 0 89.37 15 22 62 22 2090 213.5 7.47 14 16 16 19 20 23 278268.4453 36074227.06 37101151.78 35728263.31 2 21 22 20 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus protein binding;structural molecule activity;transporter activity 8021 ENSG00000126883.16 NUP214 9 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; HuR (ELAVL1) binds and stabilizes mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins Epstein-Barr virus infection; RNA transport 0 High P39023 60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2 0 36.801 37 15 60 15 403 46.1 10.18 10 11 11 11 11 18 17 14 20842372.53 31797296.81 38565443.81 26468925.16 13 11 13 11 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00297 6122 ENSG00000100316.15 RPL3 22 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P17844 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1 0 53.954 30 19 59 13 614 69.1 8.92 10 8 16 13 12 8 24 15 28258666.28 29116334.31 46003543.88 30269065.72 16 16 18 16 cell differentiation;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08061" 1655 ENSG00000108654.13 DDX5 17 mRNA Splicing - Major Pathway Spliceosome; Proteoglycans in cancer; Transcriptional misregulation in cancer 5 High P36578 60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5 0 59.196 39 17 59 17 427 47.7 11.06 10 15 13 7 11 20 19 9 25098911.97 33234642.23 32093139.94 19015218.09 16 17 15 12 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00573, Pf14374" 6124 ENSG00000174444.14 RPL4 15 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9UNF1 Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2 0 71.257 35 18 59 18 606 64.9 9.32 17 11 6 31 15 13 1114196.438 88216228.09 26389492.5 23037512.22 4 20 17 12 transport cytosol;extracellular;membrane;nucleus;organelle lumen protein binding Pf01454 10916 ENSG00000102316.16 MAGED2 X Platelet degranulation 0 High Q5M775 Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1 0 2.539 1 2 57 2 1068 118.5 6.7 1 1 2 1 4 8 11 34 2264624213 2969618377 2002543918 4157205328 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoskeleton;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;transporter activity "Pf00307, Pf01496, Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05478, Pf05667, Pf06160, Pf07888, Pf09730, Pf10174, Pf11971, Pf12128" 92521 ENSG00000128487.16 SPECC1 17 0 High Q9UBS9 SUN domain-containing ossification factor OS=Homo sapiens OX=9606 GN=SUCO PE=1 SV=1 0 85.521 23 22 57 22 1254 139.3 5.01 3 22 3 4 3 46 3 5 11782729.96 228741957.8 12421302.25 13426527.09 10 22 12 11 development;regulation of biological process endoplasmic reticulum;membrane "Pf07738, Pf12004" 51430 ENSG00000094975.13 SUCO 1 0 High P51532 Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2 0 67.753 14 21 56 13 1647 184.5 7.88 15 14 9 11 18 14 11 13 18468509.41 22467742.75 16739165.69 15268495 16 17 17 16 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619" 6597 ENSG00000127616.17 SMARCA4 19 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; Formation of the beta-catenin:TCF transactivating complex; Interleukin-7 signaling 6 High P50454 Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2 0 128.622 56 18 55 18 418 46.4 8.69 18 6 46 9 1981384.953 111690502 9395786.656 8 18 10 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;organelle lumen enzyme regulator activity;protein binding;RNA binding Pf00079 871 ENSG00000149257.13 SERPINH1 11 Collagen biosynthesis and modifying enzymes 0 High Q9BUF5 Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1 0 33.751 17 7 55 1 446 49.8 4.88 2 6 5 5 3 12 20 20 320615.0938 488986.75 738390.9375 1 1 1 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 84617 ENSG00000176014.12 TUBB6 18 COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation Pathogenic Escherichia coli infection; Gap junction; Phagosome 0 High O95678 "Keratin, type II cytoskeletal 75 OS=Homo sapiens OX=9606 GN=KRT75 PE=1 SV=2" 0 37.78 14 12 55 2 551 59.5 7.74 8 8 9 7 12 11 19 13 424150.7813 86137015.5 1 2 cell death;cell differentiation cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf05957, Pf13166, Pf13514" 9119 ENSG00000170454.5 KRT75 12 Formation of the cornified envelope 0 High P53999 Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3 0 31.209 46 7 55 7 127 14.4 9.6 7 7 7 4 14 14 15 12 36607909.72 35791146.09 37212038.88 28827939.3 8 8 8 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf02229 10923 ENSG00000113387.11 SUB1 5 0 High P42166 "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" 0 66.532 34 17 54 11 694 75.4 7.66 1 17 7 9 1 29 8 16 1695524.188 48430250.03 16829620.44 28991058.17 7 18 15 14 Met-loss [N-Term] regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf03020, Pf08198, Pf11560" 7112 ENSG00000120802.13 TMPO 12 6 High Q6ZNE5 Beclin 1-associated autophagy-related key regulator OS=Homo sapiens OX=9606 GN=ATG14 PE=1 SV=1 0 78.192 34 16 54 16 492 55.3 7.01 15 13 8 28 16 10 130516484.9 27670329.25 22407690.75 17 14 11 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole protein binding "Pf06785, Pf10186" 22863 ENSG00000126775.8 ATG14 14 Macroautophagy; Interleukin-7 signaling Autophagy 0 High Q6IQ23 Pleckstrin homology domain-containing family A member 7 OS=Homo sapiens OX=9606 GN=PLEKHA7 PE=1 SV=2 0 61.238 21 21 54 21 1121 127.1 9.35 20 11 9 29 14 11 498564.8047 50310777.81 14790019.77 10626607.03 2 20 17 14 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;protein binding "Pf00169, Pf00397, Pf01576, Pf01920, Pf02463, Pf03961, Pf07798, Pf14992, Pf15409, Pf15413" 144100 ENSG00000166689.15 PLEKHA7 11 0 High Q04695 "Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2" 0 30.643 18 11 54 1 432 48.1 5.02 7 8 11 6 11 13 18 12 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol protein binding;receptor activity;signal transducer activity;structural molecule activity "Pf00038, Pf07888" 3872 ENSG00000128422.15 KRT17 17 Formation of the cornified envelope 0 High P63104 14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1 0 62.608 57 13 54 10 245 27.7 4.79 2 11 10 11 2 18 15 19 1697234.969 54543352.16 47102624.47 47827919.5 3 9 10 10 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding Pf00244 7534 ENSG00000164924.17 YWHAZ 8 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Interleukin-3, 5 and GM-CSF signaling; KSRP (KHSRP) binds and destabilizes mRNA; Activation of BAD and translocation to mitochondria ; GP1b-IX-V activation signalling; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs" Viral carcinogenesis; Pathogenic Escherichia coli infection; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 0 High Q92734 Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2 0 47.316 30 9 54 9 400 43.4 5.1 6 9 5 5 14 18 9 13 28142569 25652049.47 22719399.38 8593363.047 10 10 9 6 Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane protein binding;signal transducer activity "Pf00564, Pf08232" 10342 ENSG00000114354.13 TFG 3 COPII (Coat Protein 2) Mediated Vesicle Transport Pathways in cancer; Thyroid cancer 0 High P61353 60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2 0 31.885 51 7 54 7 136 15.8 10.56 5 6 5 5 12 17 14 11 22333840.81 36293793.81 34899751.13 24438785.25 5 5 5 5 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00467, Pf01777" 6155 ENSG00000131469.12 RPL27 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P12235 ADP/ATP translocase 1 OS=Homo sapiens OX=9606 GN=SLC25A4 PE=1 SV=4 0 34.344 40 12 54 1 298 33 9.76 4 2 7 10 7 4 14 29 177188.4844 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 291 ENSG00000151729.10 SLC25A4 4 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Mitochondrial protein import; Metabolism of proteins; Regulation of insulin secretion cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High P63208 S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2 0 75.982 77 12 53 12 163 18.6 4.54 7 9 12 11 20 22 898460.7832 34708426.41 61209112.95 52797250.05 5 10 11 14 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf01466, Pf03931" 6500 ENSG00000113558.18 SKP1 5 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Oocyte meiosis; Circadian rhythm; Herpes simplex infection; Cell cycle 0 High Q92499 ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2 0 64.242 37 21 53 21 740 82.4 7.23 14 15 11 6 17 16 12 8 22201303.71 25178301.81 19532756.36 13512395.14 20 17 18 14 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00622" 1653 ENSG00000079785.14 DDX1 2 tRNA processing in the nucleus 0 High P62241 40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2 0 35.247 46 9 53 9 208 24.2 10.32 7 8 9 8 9 15 16 13 23365052.66 41029780.88 37369057.92 26541235.25 9 9 9 9 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01201 6202 ENSG00000142937.11 RPS8 1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q9BYQ4 Keratin-associated protein 9-2 OS=Homo sapiens OX=9606 GN=KRTAP9-2 PE=1 SV=2 0 79.422 41 4 53 2 174 18.3 7.69 4 53 193820471.8 5 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol protein binding 83899 ENSG00000239886.5 KRTAP9-2 17 Keratinization 2 High Q8N5F7 NF-kappa-B-activating protein OS=Homo sapiens OX=9606 GN=NKAP PE=1 SV=1 0 62.626 30 11 52 7 415 47.1 10.11 6 11 7 8 10 19 11 12 37746999.63 53096117.63 28596484.09 40075356.44 10 10 9 9 cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus DNA binding;protein binding;RNA binding Pf06047 79576 ENSG00000101882.9 NKAP X 3 High Q9UKV8 Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3 0 66.146 32 22 52 15 859 97.1 9.19 11 17 6 9 13 22 7 10 20249820.13 30400566 13132097.44 11056824.44 17 16 14 12 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 27161 ENSG00000123908.11 AGO2; EIF2C2 8 Post-transcriptional silencing by small RNAs; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation 5 High Q9UBU6 Protein FAM8A1 OS=Homo sapiens OX=9606 GN=FAM8A1 PE=1 SV=1 0 83.075 35 11 50 11 413 44.1 7.21 11 4 41 9 355397841.4 11220925.75 11 7 membrane Pf06271 51439 ENSG00000137414.5 FAM8A1 6 0 High P62249 40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2 0 30.149 63 10 50 10 146 16.4 10.21 5 10 10 7 6 18 15 11 12082847.13 23327340.94 20395797.13 14457313.81 10 11 11 9 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00380 6217 ENSG00000105193.8 RPS16 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q14457 Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2 0 81.994 40 19 50 19 450 51.9 4.89 18 4 7 34 6 10 349541.9531 176832062.5 37840631.04 37596698.89 2 18 13 13 cell communication;cell death;cell division;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus;vacuole protein binding "Pf04111, Pf12777, Pf13851, Pf15285" 8678 ENSG00000126581.12 BECN1 17 Ub-specific processing proteases; Macroautophagy; Interleukin-7 signaling Apoptosis - multiple species; Autophagy 0 High Q9BYP9 Keratin-associated protein 9-9 OS=Homo sapiens OX=9606 GN=KRTAP9-9 PE=2 SV=1 0 64.29 47 4 49 2 154 16.3 7.77 4 49 37669919.63 4 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 81870 ENSG00000267728.3 KRTAP9-9 17; CHR_HSCHR17_5_CTG4 Keratinization 0 High P01857 Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1 0 4.993 8 3 49 3 330 36.1 8.19 3 2 2 2 7 10 11 21 369259819.2 191185913.2 285959212.3 292654611.3 3 3 3 3 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity;metal ion binding;protein binding "Pf07654, Pf08205" 3500 ENSG00000277633.5; ENSG00000211896.7 IGHG1 14; CHR_HSCHR14_3_CTG1 Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis 0 High Q08211 ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4 0 62.992 21 19 49 19 1270 140.9 6.84 11 11 11 6 14 14 14 7 12999499.14 18386224.49 18339778.91 8481391.734 16 18 18 8 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717" 1660 ENSG00000135829.16 DHX9 1 TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; mRNA Splicing - Major Pathway; DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0 High P61247 40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2 0 33.342 42 11 49 11 264 29.9 9.73 7 10 9 7 10 14 15 10 14414087.31 27123585.56 23546376.66 15198096.25 11 11 11 10 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01015 6189 ENSG00000145425.9 RPS3A 4 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q02878 60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3 0 47.533 42 13 49 13 288 32.7 10.58 7 11 8 11 9 15 10 15 24463607.88 48289526.13 36825803.31 34093212.13 12 13 12 13 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf01159, Pf03868" 6128 ENSG00000089009.15 RPL6 12 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62906 60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2 0 41.583 33 8 49 8 217 24.8 9.94 7 8 6 5 12 15 12 10 23793911.66 39122325.66 35362610.66 17100783.75 10 10 10 8 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00687 4736 ENSG00000198755.10 RPL10A 6 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9Y3I0 RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1 0 49.472 34 12 49 12 505 55.2 7.23 8 11 11 8 10 17 13 9 12408830.87 26136161.45 16683885.95 8227627.656 10 11 11 9 metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf01139 51493 ENSG00000100220.11 C22orf28; RTCB 22 tRNA processing in the nucleus 0 High P67809 Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3 0 44.955 53 7 48 4 324 35.9 9.88 6 6 7 7 13 11 14 10 7517070.75 10784232.13 15204727 9920462.938 5 4 5 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf00313 4904 ENSG00000065978.18 YBX1 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway 0 High P02768 Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2 0 23.158 8 6 48 6 609 69.3 6.28 3 6 6 6 5 14 15 14 14787768.54 41098742.09 56141437.38 51275062.69 4 6 6 6 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus;organelle lumen antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding Pf00273 213 ENSG00000163631.16 ALB 4 "Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma; Platelet degranulation ; Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR); HDL remodeling; Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR); Transport of organic anions; Recycling of bile acids and salts" Thyroid hormone synthesis 0 High Q8NDV7 Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2 0 46.673 11 15 48 14 1962 210.2 7.01 11 12 6 7 15 17 7 9 10529793.97 17223060.97 4604064.844 8584925.25 11 12 7 9 regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi protein binding;RNA binding "Pf10427, Pf13893, Pf14259" 27327 ENSG00000090905.18 TNRC6A 16 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 1 High P05387 60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1 0 53.404 78 7 47 7 115 11.7 4.54 5 6 6 7 9 11 11 16 17676863.38 35377869.78 34395681.53 33756940.16 7 8 8 8 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;structural molecule activity Pf00428 6181 ENSG00000177600.8 RPLP2 11 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P18124 60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1 0 30.54 31 10 47 10 248 29.2 10.65 5 8 7 8 6 13 14 14 15894955.94 27365811.56 26591751.06 19737297.53 11 10 11 10 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf00327, Pf08079" 6129 ENSG00000147604.13 RPL7 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P27348 14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1 0 62.347 51 14 46 10 245 27.7 4.78 3 12 10 9 3 14 12 17 2917834.327 61326320.88 43896605.6 44207625.34 6 10 10 11 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion protein binding Pf00244 10971 ENSG00000134308.13 YWHAQ 2 Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs Viral carcinogenesis; Pathogenic Escherichia coli infection; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 1 High Q92841 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2 0 53.365 26 17 45 11 729 80.2 8.27 8 13 12 7 8 14 16 7 6092545.219 10529815.53 6906662.75 4555575.219 9 9 8 6 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 10521 ENSG00000100201.20 DDX17 22 0 High P10809 "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" 0 83.931 34 15 45 15 573 61 5.87 4 4 15 5 5 4 25 11 12008376.21 10884100.39 30559980.42 23364880.77 10 10 14 11 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endosome;membrane;mitochondrion;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding Pf00118 3329 ENSG00000144381.16 HSPD1 2 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Mitochondrial protein import; Metabolism of proteins Type I diabetes mellitus; Tuberculosis; RNA degradation; Legionellosis 0 High P15880 40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2 0 35.032 45 12 45 12 293 31.3 10.24 4 9 8 10 5 14 12 14 8615280.531 33115680.66 28422841.66 28220208.44 6 10 10 11 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00333, Pf03719" 6187 ENSG00000140988.15 RPS2 16 "Peptide chain elongation; Protein methylation; Eukaryotic Translation Termination; Viral mRNA Translation; RMTs methylate histone arginines; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P78406 mRNA export factor OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1 0 49.118 45 14 45 14 368 40.9 7.83 10 13 11 13 19 13 420415603 495247501.3 499378693.9 630395197.8 6 15 13 11 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;nucleus protein binding;RNA binding Pf00400 8480 ENSG00000101146.12 RAE1 20 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport; Influenza A 0 High P42167 "Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" 0 46.97 39 12 44 6 454 50.6 9.38 1 12 7 6 1 21 10 12 1207528.063 46600952.31 52858209.44 12612931 3 4 4 3 Met-loss [N-Term] regulation of biological process chromosome;cytoplasm;membrane;nucleus DNA binding;protein binding "Pf03020, Pf08198" 7112 ENSG00000120802.13 TMPO 12 Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High P14923 Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3 0 93.294 38 20 44 18 745 81.7 6.14 5 2 20 1 6 2 35 1 5446923.609 11641990.59 56186448.66 10634539.45 10 12 19 11 Acetyl [N-Term] cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen protein binding;signal transducer activity;structural molecule activity Pf00514 3728 ENSG00000173801.16 JUP 17 Adherens junctions interactions; Neutrophil degranulation; Formation of the cornified envelope; VEGFR2 mediated vascular permeability Arrhythmogenic right ventricular cardiomyopathy (ARVC); Acute myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer 3 High P25705 "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" 0 55.074 31 14 44 14 553 59.7 9.13 2 3 13 11 2 3 19 20 3930314.07 8868749.375 37169580.19 45316437.13 8 11 12 12 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00006, Pf00306, Pf02663, Pf02874, Pf05943" 498 ENSG00000152234.15 ATP5A1 18 Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High P06748 Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2 0 39.555 54 11 43 11 294 32.6 4.78 2 4 10 6 2 12 21 8 8479638.594 15898450.53 39048267.34 45340724.28 6 7 11 8 Acetyl [N-Term] cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;protein binding;RNA binding Pf03066 4869 ENSG00000181163.13 NPM1 5 Nuclear import of Rev protein; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deposition of new CENPA-containing nucleosomes at the centromere 0 High Q86X95 Corepressor interacting with RBPJ 1 OS=Homo sapiens OX=9606 GN=CIR1 PE=1 SV=1 0 27.693 24 11 43 11 450 52.3 9.86 8 10 7 5 11 15 9 8 20467026.69 25846887.41 17901932.29 11364544.66 11 10 9 6 metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding Pf10197 9541 ENSG00000138433.15 CIR1 2 Notch signaling pathway 0 High O43390 Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1 0 47.348 27 16 43 10 633 70.9 8.13 6 10 12 5 8 13 16 6 11631674.09 21556495.5 28333403.72 9960187 14 14 15 9 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10236 ENSG00000282958.1; ENSG00000125944.18 HNRNPR 1; CHR_HSCHR1_4_CTG3 mRNA Splicing - Major Pathway 5 High Q96RN5 Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2 0 41.045 13 10 43 10 788 86.7 9.42 5 5 10 5 9 11 15 8 18360795.02 32981118.88 27813125.44 15160127.13 8 8 10 7 metabolic process;regulation of biological process cytoplasm;membrane;nucleus protein binding Pf09606 51586 ENSG00000099917.17 MED15 22 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 High P23246 "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" 0 43.946 25 14 43 13 707 76.1 9.44 11 9 10 7 13 10 12 8 24477336.16 18872385.78 21400491.56 13431375.19 13 13 13 12 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 6421 ENSG00000116560.10 SFPQ 1 PTK6 Regulates Proteins Involved in RNA Processing 1 High P23396 40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2 0 30.708 49 12 42 12 243 26.7 9.66 7 10 8 9 7 13 11 11 12083681.81 28554852.25 24636285.34 23372243.38 9 11 10 11 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity "Pf00189, Pf07650" 6188 ENSG00000149273.14 RPS3 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q15370 Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1 0 37.3 93 10 42 10 118 13.1 4.88 8 7 7 7 12 10 11 9 25092260.72 28325780.89 19788776.14 20723800.91 9 9 10 9 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding Pf00240 6923 ENSG00000103363.14 TCEB2; ELOB 16 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma 0 High P13639 Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4 0 48.455 23 16 42 16 858 95.3 6.83 2 8 11 11 3 9 15 15 8826474.215 16167242.5 26192099.88 26625614.45 11 13 12 15 Met-loss [N-Term] cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 1938 ENSG00000167658.15 EEF2 19 Peptide chain elongation; Protein methylation; Synthesis of diphthamide-EEF2; Neutrophil degranulation; Uptake and function of diphtheria toxin Oxytocin signaling pathway; AMPK signaling pathway 0 High P46781 40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3 0 20.792 45 9 42 9 194 22.6 10.65 6 7 7 7 7 11 12 12 15883009.06 38795553.38 32481393.06 26773436 7 9 9 8 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity "Pf00163, Pf01479" 6203 ENSG00000274005.3; ENSG00000275323.3; ENSG00000277079.3; ENSG00000278081.3; ENSG00000277359.3; ENSG00000170889.13; ENSG00000274950.4; ENSG00000274626.3; ENSG00000278270.4; ENSG00000274646.4 RPS9 19; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62244 40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2 0 22.091 55 8 42 8 130 14.8 10.13 3 7 7 4 8 11 12 11 13264674.66 22540968.25 30382048.48 22984845 10 9 10 8 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00410 6210 ENSG00000134419.15 RPS15A 16 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P78527 DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3 0 46.165 5 21 41 21 4128 468.8 7.12 9 10 16 11 11 19 2477401.68 9908686.281 11317292.3 13338781.11 9 15 16 17 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00454, Pf02259, Pf02260, Pf08163" 5591 ENSG00000253729.7 PRKDC 8 Nonhomologous End-Joining (NHEJ); E3 ubiquitin ligases ubiquitinate target proteins; IRF3-mediated induction of type I IFN Non-homologous end-joining; Cell cycle 0 High P52272 Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3 0 57.727 31 17 40 17 730 77.5 8.7 11 4 12 6 14 5 14 7 18690327.88 16746008.97 30879564.72 11596382.41 14 13 15 7 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf11532, Pf11608, Pf13893, Pf14259" 4670 ENSG00000099783.11 HNRNPM 19 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High P50402 Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1 0 53.234 54 13 40 13 254 29 5.5 1 12 4 9 1 21 5 13 816203.1406 120330494.5 28111022.94 57094814.88 3 12 10 12 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus protein binding Pf03020 2010 ENSG00000102119.10 EMD X Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM) 0 High Q9BYQ0 Keratin-associated protein 9-8 OS=Homo sapiens OX=9606 GN=KRTAP9-8 PE=1 SV=2 0 43.585 45 3 40 1 159 16.7 7.61 3 40 1121159.375 1 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 83901 ENSG00000187272.6 KRTAP9-8 17 Keratinization 0 High P08670 Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4 0 40.119 34 14 39 14 466 53.6 5.12 12 10 7 6 15 11 7 6 18856884 15117111.53 11759430.34 5813952.813 12 12 12 8 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186" 7431 ENSG00000026025.15 VIM 10 Interleukin-4 and 13 signaling; Caspase-mediated cleavage of cytoskeletal proteins; Striated Muscle Contraction MicroRNAs in cancer; Epstein-Barr virus infection 0 High P62277 40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2 0 29.523 46 8 39 8 151 17.2 10.54 5 8 6 4 9 13 11 6 20213786.31 42299978.31 37302911.5 26665939.56 7 8 8 7 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00312, Pf08069" 6207 ENSG00000110700.6 RPS13 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q16777 Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4 0 27.698 41 7 38 2 129 14 10.9 3 5 7 4 7 9 14 8 20072852.84 56194920.94 101849030.4 28630400.22 6 6 8 5 regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 8338 ENSG00000184260.5 HIST2H2AC 1 SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Systemic lupus erythematosus; Alcoholism 6 High P16989 Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4 0 36.728 42 7 38 4 372 40.1 9.77 5 6 6 7 9 9 10 10 8513860.406 15124695.13 14933667.81 10534097.56 8 9 8 8 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding Pf00313 8531 ENSG00000060138.12 CSDA; YBX3 12 Tight junction 4 High P61981 14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2 0 48.824 54 14 38 8 247 28.3 4.89 1 12 9 6 1 15 11 11 493114.8594 38055677.25 22081993.84 14630130.78 2 7 9 6 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion enzyme regulator activity;protein binding;RNA binding Pf00244 7532 ENSG00000170027.6 YWHAG 7 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs Viral carcinogenesis; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 2 High Q5QNW6 Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3 0 19.763 47 6 38 1 126 13.9 10.32 4 4 6 3 8 9 14 7 1851358.5 6788099 8346881 2806251.25 1 1 1 1 cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 440689 ENSG00000203814.6 HIST2H2BF 1 HDACs deacetylate histones; HATs acetylate histones; Ub-specific processing proteases Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 0 High P62269 40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3 0 24.565 48 9 38 9 152 17.7 10.99 5 7 7 4 9 10 12 7 22865233.13 37185501.88 26135954.47 26228698.5 10 10 9 10 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00416 6222 ENSG00000223367.6; ENSG00000096150.9; ENSG00000235650.6; ENSG00000226225.6; ENSG00000231500.6 RPS18 6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P31946 14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3 0 47.582 43 11 38 5 246 28.1 4.83 1 10 8 7 1 12 11 14 275609.4688 20275718 13257769.59 13254483.19 2 4 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding Pf00244 7529 ENSG00000166913.12 YWHAB 20 "MAP2K and MAPK activation; mTORC1-mediated signalling; Negative regulation of MAPK pathway; ARMS-mediated activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Interleukin-20 family signaling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by BRAF and RAF fusions; Signaling by Hippo; Activation of BAD and translocation to mitochondria ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; TP53 Regulates Metabolic Genes; RAF activation; RHO GTPases activate PKNs" Viral carcinogenesis; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 0 High Q9Y385 Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2 0 64.789 32 11 38 11 318 35.2 6.74 10 10 14 24 8753555.344 8975897.516 40862658.75 84532243.34 3 3 11 11 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding Pf00179 51465 ENSG00000198833.6 UBE2J1 6 Antigen processing: Ubiquitination & Proteasome degradation Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson's disease 0 High Q12906 Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3 0 34.587 13 9 37 9 894 95.3 8.76 6 8 8 5 9 12 10 6 8517924.563 13321239.44 14342435.69 8552628.875 6 8 8 7 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular;membrane;mitochondrion;nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf07528, Pf14709" 3609 ENSG00000129351.17 ILF3 19 0 High Q16778 Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3 0 19.796 47 6 37 1 126 13.9 10.32 4 4 6 3 8 8 14 7 23407851.31 56222953.69 143067680.5 29071918.5 5 5 7 4 cell organization and biogenesis;defense response;response to stimulus chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 8349 ENSG00000184678.10 HIST2H2BE 1 SIRT1 negatively regulates rRNA expression; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 6 High A8MTY7 Keratin-associated protein 9-7 OS=Homo sapiens OX=9606 GN=KRTAP9-7 PE=3 SV=1 0 65.532 43 4 37 3 169 17.8 7.58 4 37 39273901.06 4 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 100505724 ENSG00000262221.1; ENSG00000180386.7 KRTAP9-7 17; CHR_HSCHR17_6_CTG4 Keratinization 0 High Q9UKB1 F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1 0 53.268 27 14 37 8 542 62.1 7.12 8 12 9 11 15 11 1147895.25 28153664.38 43209835.38 36109066.48 1 10 11 11 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00400, Pf00646, Pf08801, Pf12125, Pf12937" 23291 ENSG00000072803.17 FBXW11 5 Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Neddylation; Activated TLR4 signalling; Interleukin-1 family signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling Ubiquitin mediated proteolysis; Hippo signaling pathway; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Shigellosis 5 High P49411 "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2" 0 47.122 34 12 37 12 452 49.5 7.61 4 7 9 8 4 10 12 11 4387581.969 21503963.84 22523254.5 25234732.94 8 10 10 10 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 7284 TUFM 16 Mitochondrial translation elongation 0 High P30050 60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1 0 25.387 45 5 37 5 165 17.8 9.42 5 5 5 3 11 11 10 5 16508269.38 30683898.5 25863062.75 17144295.5 5 5 5 4 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 6136 ENSG00000197958.12 RPL12 9 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9BT22 Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG1 PE=1 SV=2 0 26.021 15 6 37 6 464 52.5 7.23 5 5 5 17 12 8 52266997 30372656.36 22568448.69 5 5 5 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00534, Pf13692" 56052 ENSG00000033011.11 ALG1 16 "Defective ALG1 causes ALG1-CDG (CDG-1k); Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" N-Glycan biosynthesis; Metabolic pathways 0 High P55795 Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1 0 39.19 18 6 37 1 449 49.2 6.3 6 5 6 5 11 9 11 6 824839.875 1097177.125 1439073 652610.6875 1 1 1 1 metabolic process cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3188 ENSG00000126945.8 HNRNPH2 X mRNA Splicing - Major Pathway 0 High P62263 40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3 0 36.898 33 6 37 6 151 16.3 10.05 3 6 6 6 5 9 9 14 5584360.75 12263332.31 14590799.19 16218045.47 6 6 6 7 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity Pf00411 6208 ENSG00000164587.11 RPS14 5 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P62805 Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2 0 34.606 51 6 36 6 103 11.4 11.36 4 6 5 2 6 10 17 3 6486219.016 31925278.07 63072264.75 14758563.44 6 8 8 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00125, Pf02969, Pf15630" 8359; 8361; 8360; 8363; 8370; 554313; 8365; 8364; 121504; 8367; 8294; 8366; 8362; 8368 ENSG00000197061.4; ENSG00000275126.1; ENSG00000273542.1; ENSG00000197238.4; ENSG00000197837.3; ENSG00000276966.2; ENSG00000158406.4; ENSG00000270882.2; ENSG00000274618.1; ENSG00000278637.1; ENSG00000277157.1; ENSG00000278705.1; ENSG00000270276.2; ENSG00000276180.1 HIST1H4A; HIST1H4F; HIST1H4D; HIST1H4J; HIST2H4A; HIST2H4B; HIST1H4H; HIST1H4C; HIST4H4; HIST1H4E; HIST1H4I; HIST1H4B; HIST1H4K; HIST1H4L 6; 1; 12 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of chromatin organization proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism 0 High P26373 60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4 0 21.013 36 8 36 8 211 24.2 11.65 5 6 8 6 7 9 10 10 12383496.75 29709184.44 24003132.69 15274974.31 6 7 8 7 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01294 6137 ENSG00000167526.13 RPL13 16 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62280 40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3 0 35.081 54 9 36 9 158 18.4 10.3 6 6 8 5 8 9 12 7 21306728.81 42561530.13 30396014.63 19675601 10 10 8 8 cell differentiation;cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00366 6205 ENSG00000142534.6 RPS11 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P05388 60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 0 45.492 30 8 36 8 317 34.3 5.97 4 6 8 5 5 10 13 8 9371820.375 14188361.63 18329997.44 13334805.92 7 6 6 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00428, Pf00466" 6175 ENSG00000089157.15 RPLP0 12 Peptide chain elongation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Interleukin-12 family signaling Ribosome 0 High P62829 60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1 0 40.455 58 9 36 9 140 14.9 10.51 2 8 7 4 4 16 9 7 8858643.039 21714368.03 28886884.03 24350788.72 6 6 7 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00238 9349 ENSG00000125691.12 RPL23 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P10321 "HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" 0 77.86 49 14 36 8 366 40.6 6.04 1 1 3 14 1 1 4 30 2209902.445 3560716.031 7812487.594 175427567.8 4 5 7 17 regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;Golgi;membrane protein binding "Pf00129, Pf07654" 3107 ENSG00000204525.16 HLA-C 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation 8 High Q7L014 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2 0 32.446 15 13 36 13 1031 117.3 9.29 10 9 6 5 12 11 7 6 14346591.95 14561743.91 14865532.03 9035950.938 13 13 12 11 metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271" 9879 ENSG00000145833.15 DDX46 5 mRNA Splicing - Major Pathway Spliceosome 0 High Q07020 60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2 0 24.12 36 7 35 7 188 21.6 11.72 5 6 7 5 7 9 11 8 12923305.06 25021052.63 23672824.81 18450119.69 6 6 6 6 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00828 6141 ENSG00000063177.12 RPL18 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P63173 60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2 0 24.6 53 6 35 6 70 8.2 10.1 3 5 4 5 5 14 8 8 12327325.72 28758282.88 19154125.3 11638983.42 6 6 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;ribosome RNA binding;structural molecule activity Pf01781 6169 ENSG00000172809.12 RPL38 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9HCD5 Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2 0 47.222 35 14 35 14 579 65.5 9.6 8 5 9 5 10 7 11 7 16467895.44 12853521.06 13502042.56 11131872.56 15 14 13 11 metabolic process;regulation of biological process cytoskeleton;nucleus protein binding;RNA binding 57727 ENSG00000124160.11 NCOA5 20 0 High O76013 "Keratin, type I cuticular Ha6 OS=Homo sapiens OX=9606 GN=KRT36 PE=1 SV=1" 0 45.325 26 11 35 2 467 52.2 4.94 2 1 10 1 5 3 24 3 506706.9688 2979696.219 1 2 cell death;regulation of biological process cytoskeleton;cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576" 8689 ENSG00000126337.13 KRT36 17 Formation of the cornified envelope 1 High O60506 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2 0 34.954 20 12 35 6 623 69.6 8.59 7 7 8 4 9 9 12 5 3835207.156 6171345.75 7901697.156 3016483.859 6 6 6 4 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10492 ENSG00000135316.17 SYNCRIP 6 0 High Q15464 SH2 domain-containing adapter protein B OS=Homo sapiens OX=9606 GN=SHB PE=1 SV=2 0 58.782 39 13 34 13 509 55 8.9 13 6 4 24 6 4 921564.8125 87761495.78 6903797.781 9764392.625 1 12 7 10 cell death;cell differentiation;cell proliferation;development;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding Pf00017 6461 ENSG00000107338.9 SHB 9 VEGFA-VEGFR2 Pathway 0 High P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1 0 51.09 45 12 34 4 330 37.5 6.33 1 10 7 6 1 13 10 10 3353282.453 17932017.88 15508016 20081059.44 5 11 8 9 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf00149 5499 ENSG00000172531.14 PPP1CA 11 Signaling by GPCR; Triglyceride catabolism; DARPP-32 events; Downregulation of TGF-beta receptor signaling; Circadian Clock Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation 8 High Q92804 TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1 0 31.465 23 8 34 6 592 61.8 8.02 5 8 5 3 9 11 8 6 7955849.031 14761305.59 16449895.11 5930599.891 5 6 5 4 regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" 8148 ENSG00000270647.5; ENSG00000276833.2 TAF15 17; CHR_HSCHR17_7_CTG4 Basal transcription factors; Transcriptional misregulation in cancer 0 High Q8IZD2 Inactive histone-lysine N-methyltransferase 2E OS=Homo sapiens OX=9606 GN=KMT2E PE=1 SV=1 0 41.069 12 13 34 13 1858 204.8 7.61 5 12 8 5 19 10 380703.9688 5077520.781 11711888.75 7348702.469 1 10 12 8 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00628, Pf00856, Pf07223, Pf09770" 55904 ENSG00000005483.20 KMT2E; MLL5 7 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Lysine degradation 0 High Q8TAQ2 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1 0 33.172 9 10 33 4 1214 132.8 5.69 7 8 6 4 9 11 7 6 2586964.406 3519527 2574869.422 1139519.766 4 4 4 3 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf04433 6601 ENSG00000139613.11 SMARCC2 12 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High P36542 "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" 0 25.095 24 7 33 7 298 33 9.22 5 5 6 6 6 6 9 12 8126664.906 12474693.56 15919152.5 18001231 6 6 6 5 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;organelle lumen catalytic activity;RNA binding;transporter activity Pf00231 509 ENSG00000165629.19 ATP5C1 10 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q86TM6 E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2 0 45.587 18 13 33 13 617 67.6 6.95 13 5 27 6 274939.5 500630.2656 193718984.8 17536665.81 1 2 13 10 metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" 84447 ENSG00000162298.18 SYVN1 11 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes; Hedgehog ligand biogenesis Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 High P10412 Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2 0 25.245 33 8 33 2 219 21.9 11.03 4 6 8 5 5 9 12 7 8514862.563 14373472.88 22037792.88 11538802.13 6 6 6 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00538 3008 ENSG00000168298.6 HIST1H1E 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 5 High Q93077 Histone H2A type 1-C OS=Homo sapiens OX=9606 GN=H2AC6 PE=1 SV=3 0 22.539 41 6 33 1 130 14.1 11.05 2 4 6 3 6 8 12 7 159635.8906 1234681.25 1 1 regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 8334 ENSG00000180573.9 HIST1H2AC 6 SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence Systemic lupus erythematosus; Alcoholism 0 High Q9Y297 F-box/WD repeat-containing protein 1A OS=Homo sapiens OX=9606 GN=BTRC PE=1 SV=1 0 44.42 22 12 33 6 605 68.8 7.96 7 10 8 10 13 10 1999049.688 5676272.5 3330518.328 4 5 4 cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00400, Pf00646, Pf08801, Pf12125, Pf12937" 8945 ENSG00000166167.17 BTRC 10 Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Deactivation of the beta-catenin transactivating complex; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling Ubiquitin mediated proteolysis; Hippo signaling pathway; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Shigellosis 0 High P04406 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3 0 39.502 30 8 33 8 335 36 8.46 3 3 8 5 3 4 18 8 5047608.703 57595334.06 63113388.13 54099024.31 6 7 8 6 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00044, Pf02800" 2597 ENSG00000111640.14 GAPDH 12 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Alzheimer's disease; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High P48047 "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" 0 20.689 33 5 32 5 213 23.3 9.96 3 3 5 4 8 7 10 7 7181168.375 5833329.625 9492531.719 10291817.13 3 3 4 4 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf00213 539 ENSG00000241837.6 ATP5O 21 Cristae formation; Formation of ATP by chemiosmotic coupling Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High Q04917 14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4 0 34.636 37 11 32 7 246 28.2 4.84 1 11 6 5 1 14 7 10 364849888 383165740.2 392501671.7 185382708.7 1 6 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion catalytic activity;protein binding Pf00244 7533 ENSG00000128245.14 YWHAH 22 Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs Viral carcinogenesis; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway 0 High Q92945 Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4 0 35.562 21 11 32 11 711 73.1 7.3 5 7 6 7 5 10 8 9 8562555.5 13482931.44 7887771.906 9368153.313 8 8 7 7 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf07650, Pf09005, Pf13014" 8570 ENSG00000088247.17 KHSRP 19 ATF4 activates genes; KSRP (KHSRP) binds and destabilizes mRNA 0 High P40429 60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2 0 22.12 46 10 32 10 203 23.6 10.93 6 7 6 3 8 12 8 4 8778633.844 19934797.03 17230841.28 8218545.281 9 9 9 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00572 23521 ENSG00000142541.16 RPL13A 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q99729 Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2 0 17.325 22 7 32 6 332 36.2 8.21 6 5 7 3 9 8 12 3 6462192.75 13566060.69 15713553 6357219.188 6 6 6 5 cell organization and biogenesis;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08143, Pf13893, Pf14259" 3182 HNRNPAB 5 0 High P62917 60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2 0 29.782 43 8 32 8 257 28 11.03 5 7 6 6 7 9 8 8 14370787 24418982.09 25595537.69 18235421.17 7 9 8 8 cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity "Pf00181, Pf03947" 6132 ENSG00000161016.17 RPL8 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P0C2W1 F-box/SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FBXO45 PE=1 SV=1 0 28.218 42 10 32 10 286 30.6 7.83 7 10 8 9 13 10 671249.5938 24506843.13 35532989.38 26019825.5 2 10 11 10 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;development;metabolic process;response to stimulus membrane protein binding "Pf00622, Pf00646, Pf12937" 200933 ENSG00000174013.7 FBXO45 3 0 High P33993 DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4 0 40.647 25 15 32 15 719 81.3 6.46 2 4 10 10 2 4 13 13 2736098.039 4012852.859 11224196.41 13405128.66 9 10 13 14 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 4176 ENSG00000166508.17 MCM7 7 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q9BYQ5 Keratin-associated protein 4-6 OS=Homo sapiens OX=9606 GN=KRTAP4-6 PE=2 SV=4 0 45.477 29 2 32 1 205 21.8 7.94 2 32 787859552.1 252101.75 5 1 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 81871 ENSG00000198090.3 KRTAP4-6 17 Keratinization 1 High P26641 Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3 0 27.78 23 8 31 8 437 50.1 6.67 6 7 8 3 8 7 12 4 7061956.625 8897804.75 10589002.88 6412130.625 6 6 6 5 metabolic process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497" 1937 ENSG00000254772.9 EEF1G 11 Eukaryotic Translation Elongation Legionellosis 0 High O75390 "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" 0 23.92 17 8 31 8 466 51.7 8.32 1 4 8 7 1 7 12 11 1260426.922 22986688.56 29402298.69 21039196.06 4 8 8 8 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;RNA binding Pf00285 1431 ENSG00000062485.18 CS 12 Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism 0 High P14868 "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" 0 37.082 32 14 31 14 501 57.1 6.55 7 8 7 7 8 9 7 7 5513962.469 7585233.703 8416173.953 5735307.234 9 12 11 9 cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf01336" 1615 ENSG00000115866.10 DARS 2 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High P55072 Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4 0 76.513 34 21 31 21 806 89.3 5.26 1 1 21 2 1 1 27 2 5585373.938 2007136.563 37331809 5619440.422 7 5 17 9 Met-loss+Acetyl [N-Term] cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401" 7415 ENSG00000165280.15 VCP 9 Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs; Ovarian tumor domain proteases; ABC-family proteins mediated transport; HSF1 activation; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; E3 ubiquitin ligases ubiquitinate target proteins; Neutrophil degranulation; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis Protein processing in endoplasmic reticulum; Legionellosis 0 High P01024 Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2 0 21.572 6 8 31 8 1663 187 6.4 8 6 7 11 10 10 34542295.38 37887284.38 33551282.13 8 7 8 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974" 718 ENSG00000125730.16 C3 19 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Alternative complement activation; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; G alpha (i) signalling events Viral carcinogenesis; Chagas disease (American trypanosomiasis); Leishmaniasis; Tuberculosis; Pertussis; Phagosome; Complement and coagulation cascades; Systemic lupus erythematosus; Herpes simplex infection; Staphylococcus aureus infection; Legionellosis 0 High P38435 Vitamin K-dependent gamma-carboxylase OS=Homo sapiens OX=9606 GN=GGCX PE=1 SV=2 0 27.881 16 12 31 12 758 87.5 8.02 9 10 3 13 13 5 151220.375 20043175.34 19119641.56 4464331.125 1 11 10 7 Met-loss+Acetyl [N-Term] coagulation;metabolic process endoplasmic reticulum;membrane catalytic activity Pf05090 2677 ENSG00000115486.11 GGCX 2 Gamma-carboxylation of protein precursors Ubiquinone and other terpenoid-quinone biosynthesis 0 High P52597 Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3 0 48.968 28 7 31 5 415 45.6 5.58 3 6 6 5 4 8 10 9 2089128.188 4624977.375 4133806.25 1862599.875 3 4 4 3 metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 3185 ENSG00000169813.16 HNRNPF 10 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Interleukin-12 family signaling 0 High O60762 Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=DPM1 PE=1 SV=1 0 57.363 50 11 30 11 260 29.6 9.57 1 9 7 1 19 10 778497.4141 1176988.969 64887379.66 43975599.42 4 4 12 12 Met-loss+Acetyl [N-Term] metabolic process endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding "Pf00535, Pf10111, Pf13641, Pf13704, Pf13712" 8813 ENSG00000000419.12 DPM1 20 Defective DPM1 causes DPM1-CDG (CDG-1e); Synthesis of dolichyl-phosphate mannose N-Glycan biosynthesis; Metabolic pathways 0 High Q6A163 "Keratin, type I cytoskeletal 39 OS=Homo sapiens OX=9606 GN=KRT39 PE=1 SV=2" 0 66.567 43 15 30 15 491 55.6 5.26 15 30 386308.4063 44264809.88 520859.5625 1 16 1 cell death;regulation of biological process cytosol catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf02463, Pf05557, Pf05622, Pf12128" 390792 ENSG00000196859.7; ENSG00000262164.6 KRT39 17; CHR_HSCHR17_4_CTG4 Formation of the cornified envelope 0 High P83731 60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1 0 23.941 38 7 30 7 157 17.8 11.25 4 5 7 4 5 9 10 6 11289959.44 22073935 20055561.56 12966095.81 6 8 7 5 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01246 6152 ENSG00000114391.12 RPL24 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P14866 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2 0 35.097 24 9 29 9 589 64.1 8.22 5 6 8 5 5 8 9 7 7286688.453 10103374.41 9696542.75 6128348.188 7 8 7 6 metabolic process;regulation of biological process cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3191 ENSG00000282947.1; ENSG00000104824.16 HNRNPL 19; CHR_HG26_PATCH mRNA Splicing - Major Pathway 0 High P38159 "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" 0 20.437 21 8 29 8 391 42.3 10.05 5 6 7 5 8 7 9 5 10226574.31 16787819.75 14479294 11150211.78 8 8 7 6 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf08081, Pf13893, Pf14259" 27316 ENSG00000147274.14 RBMX X mRNA Splicing - Major Pathway Spliceosome 0 High Q12905 Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2 0 22.038 24 7 29 7 390 43 5.26 4 4 7 4 6 6 9 8 5769818.813 7804895.375 9644957.25 7168874 5 5 5 5 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding Pf07528 3608 ENSG00000143621.16 ILF2 1 Neutrophil degranulation 0 High Q2M1P5 Kinesin-like protein KIF7 OS=Homo sapiens OX=9606 GN=KIF7 PE=1 SV=2 0 28.143 12 10 29 10 1343 150.5 6.79 2 3 7 6 2 7 11 9 1182723736 1156133974 1190210500 845253277 5 6 8 6 cellular component movement;metabolic process;regulation of biological process cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf04111" 374654 ENSG00000166813.14 KIF7 15 Hedgehog 'on' state; Hedgehog 'off' state Hedgehog signaling pathway 0 High P61513 60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2 0 23.017 41 3 29 3 92 10.3 10.43 3 3 3 2 8 8 8 5 14784720 24442942.63 22395914.63 12678985.63 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity Pf01780 6168 ENSG00000197756.9 RPL37A 2 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P16403 Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2 0 22.436 30 7 29 1 213 21.4 10.93 3 5 6 5 4 7 10 8 603393.6875 936389.9375 752704.875 746322 1 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 3006 ENSG00000187837.3 HIST1H1C 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 0 High Q13835 Plakophilin-1 OS=Homo sapiens OX=9606 GN=PKP1 PE=1 SV=2 0 62.201 29 17 29 17 747 82.8 9.13 17 29 343266.1016 46600356.5 326178.125 3 16 1 cell death;cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport cytoskeleton;membrane;nucleus protein binding;signal transducer activity;structural molecule activity Pf00514 5317 ENSG00000081277.12 PKP1 1 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation 0 High Q00325 "Phosphate carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2" 0 24.671 23 11 29 11 362 40.1 9.38 1 3 6 10 2 3 7 17 3867231.156 6632482.859 24242761 38509190.63 6 8 9 9 transport membrane;mitochondrion protein binding;transporter activity Pf00153 5250 ENSG00000075415.12 SLC25A3 12 0 High P62750 60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1 0 16.687 28 6 29 6 156 17.7 10.45 4 5 6 4 6 6 11 6 10157700.63 22072148.5 18739614.13 12734925 6 6 6 6 cell organization and biogenesis;cell proliferation;metabolic process;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00276, Pf03939" 6147 ENSG00000198242.13 RPL23A 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P34896 "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" 0 54.844 48 18 29 17 483 53 7.71 18 29 66596141.25 5296043.547 3184140.875 449984.625 14 4 3 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding;RNA binding;translation regulator activity Pf00464 6470 ENSG00000176974.19 SHMT1 17 Metabolism of folate and pterines; Carnitine synthesis "Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism" 1 High P08708 40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2 0 36.532 59 6 28 6 135 15.5 9.85 5 3 4 2 10 6 6 6 14193623.22 18442997.88 20367622.88 8616736.938 6 5 6 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf00833 6218 ENSG00000278229.2; ENSG00000182774.10 RPS17; RPS17L 15; CHR_HSCHR15_5_CTG8 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q15369 Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1 0 32.372 57 6 28 6 112 12.5 4.78 6 5 4 5 7 7 5 9 17953095.97 25064851.44 15055444.31 14307568.91 7 7 6 7 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;protein binding;RNA binding Pf03931 6921 ENSG00000154582.16 TCEB1; ELOC 8 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-7 signaling; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of Tat-mediated HIV elongation HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma 0 High P07900 Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5 0 42.043 17 12 28 5 732 84.6 5.02 6 3 8 5 6 3 12 7 2067713.875 2305797.172 5014840.094 1357527.75 3 4 5 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 3320 ENSG00000080824.18 HSP90AA1 14 "Sema3A PAK dependent Axon repulsion; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Scavenging by Class F Receptors; Neutrophil degranulation; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); vRNP Assembly; Downregulation of ERBB2 signaling; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Constitutive Signaling by EGFRvIII; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; Attenuation phase; eNOS activation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; VEGFR2 mediated vascular permeability; PIWI-interacting RNA (piRNA) biogenesis; Interleukin-4 and 13 signaling" NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation 0 High Q9UL18 Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3 0 30.514 15 10 28 4 857 97.2 9.16 6 10 5 4 7 12 5 4 1352847.766 3564779.031 721222.0859 946263.5859 4 4 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 26523 ENSG00000092847.11 AGO1; EIF2C1 1 Post-transcriptional silencing by small RNAs; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High Q71UI9 Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3 0 10.388 23 3 28 1 128 13.5 10.58 3 3 3 3 7 7 8 6 918386.625 1222109.5 1514620.625 1159761.75 1 1 1 1 regulation of biological process chromosome;nucleus DNA binding;protein binding Pf00125 94239 ENSG00000105968.18 H2AFV 7 SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Packaging Of Telomere Ends; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening Systemic lupus erythematosus; Alcoholism 0 High O43175 D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4 0 30.593 20 8 28 8 533 56.6 6.71 3 6 7 6 3 7 9 9 3727292.094 7026066.375 10710886.63 12083241.61 7 6 8 8 metabolic process cytosol catalytic activity;nucleotide binding "Pf00389, Pf02826" 26227 ENSG00000092621.11 PHGDH 1 Serine biosynthesis "Carbon metabolism; Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways" 0 High Q9UKT8 F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2 0 41.255 19 7 28 7 454 51.5 6.58 6 6 6 7 11 10 162358.7969 18611324.63 17201549.03 16877032.78 1 6 6 5 metabolic process cytosol catalytic activity;protein binding Pf00400 26190 ENSG00000119402.16 FBXW2 9 Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q9NZC9 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1 0 41.342 19 13 27 13 954 105.9 9.06 11 10 5 11 11 5 14673577.81 17810311.41 10269257.88 11 11 8 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf07443" 50485 ENSG00000138375.12 SMARCAL1 2 0 High Q9BYQ6 Keratin-associated protein 4-11 OS=Homo sapiens OX=9606 GN=KRTAP4-11 PE=1 SV=2 0 24.88 49 3 27 2 195 20.9 7.93 3 27 381472020.4 4 cytosol protein binding 653240 ENSG00000212721.3 KRTAP4-11 17 Keratinization 1 High P07814 Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5 0 33.209 10 10 27 10 1512 170.5 7.33 5 4 6 7 7 4 7 9 5238024.625 6963307.281 6347343.078 6839903.5 6 9 8 9 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497" 2058 ENSG00000136628.17 EPRS 1 tRNA modification in the nucleus and cytosol; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Porphyrin and chlorophyll metabolism; Aminoacyl-tRNA biosynthesis; Metabolic pathways 0 High A8MXZ3 Keratin-associated protein 9-1 OS=Homo sapiens OX=9606 GN=KRTAP9-1 PE=3 SV=1 0 41.763 26 4 27 3 250 26.3 7.61 4 27 824743473.8 7 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 728318 ENSG00000240542.4 KRTAP9-1 17 Keratinization 4 High P25398 40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3 0 37.127 63 6 27 6 132 14.5 7.21 4 4 5 5 4 6 7 10 2285306.594 6163820.547 7052721.195 5152950.188 7 7 7 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01248 6206 ENSG00000112306.7 RPS12 6 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q9BYQ8 Keratin-associated protein 4-9 OS=Homo sapiens OX=9606 GN=KRTAP4-9 PE=2 SV=2 0 37.025 30 2 27 1 210 22.4 7.81 2 27 55284606.94 3 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 100132386 ENSG00000212722.7 KRTAP4-9 17 Keratinization 0 High Q2M2I8 AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3 0 41.951 23 13 26 12 961 103.8 6.6 5 11 6 6 13 7 8732748.969 9902437.5 7293692.094 11 10 9 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 22848 ENSG00000115977.18 AAK1 2 Cargo recognition for clathrin-mediated endocytosis 1 High P27824 Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2 0 38.019 23 11 26 11 592 67.5 4.6 9 8 12 14 463847.9375 1517839.016 10823136 20889178.88 1 3 10 9 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;organelle lumen;ribosome metal ion binding;protein binding;RNA binding Pf00262 821 ENSG00000127022.14; ENSG00000283777.1 CANX 5; CHR_HG30_PATCH "Assembly of Viral Components at the Budding Site; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Calnexin/calreticulin cycle; MHC class II antigen presentation" Protein processing in endoplasmic reticulum; HTLV-I infection; Phagosome; Thyroid hormone synthesis; Antigen processing and presentation 0 High P61978 Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1 0 29.274 24 9 26 9 463 50.9 5.54 5 4 7 4 6 5 9 6 8136202.125 8772194.844 16429825.41 10294288.5 7 7 8 8 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00013, Pf08067, Pf13014, Pf13083" 3190 ENSG00000165119.20 HNRNPK 9 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Viral carcinogenesis; MicroRNAs in cancer; Spliceosome; Herpes simplex infection 0 High P43243 Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2 0 30.992 17 11 26 11 847 94.6 6.25 8 6 5 2 10 7 6 3 6019480.648 6178518.094 4995522.938 3390273.688 10 9 10 9 defense response;regulation of biological process;response to stimulus membrane;nucleus metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00076, Pf13893, Pf14259" 9782 ENSG00000015479.18; ENSG00000280987.4 MATR3 5 0 High Q07021 "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" 0 31.629 28 5 26 5 282 31.3 4.84 3 5 3 4 5 11 4 6 1868262.281 11662235.13 4213457.938 3132029.375 2 4 3 2 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen protein binding;RNA binding Pf02330 708 ENSG00000108561.8 C1QBP 17 Intrinsic Pathway of Fibrin Clot Formation Herpes simplex infection 0 High Q15233 Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4 0 26.977 26 11 25 10 471 54.2 8.95 5 4 7 6 6 4 8 7 11752226.06 10485648.28 13264084.66 7204771.938 9 9 9 7 defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 4841 ENSG00000147140.15 NONO X 0 High Q9NQ29 Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1 0 20.869 21 7 25 1 371 43.7 9.92 4 4 5 6 5 6 6 8 2034023 994286.9375 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding Pf03194 55692 ENSG00000007392.16 LUC7L 16 0 High P07910 Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4 0 25.674 25 9 25 9 306 33.7 5.08 6 7 4 6 6 8 4 7 14210655.75 19864896.13 17757200.56 9287909.188 9 9 9 8 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3183 ENSG00000092199.17 HNRNPC 14 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Spliceosome 0 High P62888 60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2 0 28.096 51 4 25 4 115 12.8 9.63 3 4 4 3 5 8 9 3 4926137.031 19106981.75 16616187.63 5992681.063 3 4 4 3 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01248 6156 ENSG00000156482.10 RPL30 8 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9HCJ0 Trinucleotide repeat-containing gene 6C protein OS=Homo sapiens OX=9606 GN=TNRC6C PE=1 SV=3 0 29.231 7 9 25 8 1690 175.9 6.96 5 3 6 7 6 4 7 8 7017726.625 8192293.461 8810707.234 11073023 8 7 7 8 regulation of biological process;response to stimulus cytosol protein binding;RNA binding "Pf00076, Pf00627, Pf10427, Pf12938, Pf13893, Pf14259" 57690 ENSG00000078687.17 TNRC6C 17 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High O76015 "Keratin, type I cuticular Ha8 OS=Homo sapiens OX=9606 GN=KRT38 PE=1 SV=3" 0 25.5 22 6 25 3 456 50.4 4.84 1 1 6 1 4 3 15 3 2312353.688 2 Met-loss+Acetyl [N-Term] cell death cytosol protein binding;structural molecule activity "Pf00038, Pf02463, Pf09311" 8687 ENSG00000171360.3 KRT38 17 Formation of the cornified envelope 0 High A6NKD9 Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1 0 39.538 39 11 25 11 419 45.2 6.96 7 8 8 7 9 9 1690953.922 13998235.56 15282947.88 14855613.88 4 9 11 9 Met-loss+Acetyl [N-Term] development Pf10226 317762 ENSG00000205476.8 CCDC85C 14 0 High P17987 T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1 0 27.868 23 10 24 10 556 60.3 6.11 2 5 6 8 3 5 7 9 2392891.75 5557727.152 7415604.125 10524322.58 6 9 7 8 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi nucleotide binding;protein binding;RNA binding Pf00118 6950 ENSG00000120438.11 TCP1 6 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC; Interleukin-12 family signaling 0 High O14979 Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3 0 23.106 21 8 24 6 420 46.4 9.57 5 3 7 3 7 3 11 3 11053024.69 17634259.75 25065778.31 12517197.95 6 6 6 6 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 9987 ENSG00000152795.17 HNRNPDL; HNRPDL 4 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling 2 High Q14204 Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5 0 35.679 4 14 24 14 4646 532.1 6.4 6 4 8 6 6 4 8 6 7681590.094 5331329.094 7953638.25 5827749.094 14 10 13 12 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00769, Pf03028, Pf03915, Pf04156, Pf07246, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13173, Pf13207, Pf13401" 1778 ENSG00000197102.10 DYNC1H1 14 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High Q9NR30 Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5 0 25.985 13 9 24 9 783 87.3 9.28 4 5 7 6 5 5 8 6 5175421.578 9709434.531 10200506.44 7547149.281 9 9 9 8 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08152, Pf14617" 9188 ENSG00000165732.12 DDX21 10 Major pathway of rRNA processing in the nucleolus and cytosol; B-WICH complex positively regulates rRNA expression 0 High P61254 60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1 0 7.639 23 5 24 5 145 17.2 10.55 3 3 4 3 6 7 7 4 7577102.844 11300872.5 11031965.78 6817366.25 4 4 4 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00467 6154 ENSG00000161970.12 RPL26 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9BZ72 Membrane-associated phosphatidylinositol transfer protein 2 OS=Homo sapiens OX=9606 GN=PITPNM2 PE=1 SV=1 0 35.669 11 14 24 13 1349 148.8 7.17 8 8 6 8 9 7 814900.6406 11282363.72 7794760.453 6387959.719 2 11 10 9 metabolic process;transport cytosol;membrane metal ion binding;transporter activity "Pf02121, Pf02862, Pf08235" 57605 ENSG00000090975.12 PITPNM2 12 Synthesis of PI 1 High Q9BYR2 Keratin-associated protein 4-5 OS=Homo sapiens OX=9606 GN=KRTAP4-5 PE=1 SV=4 0 31.832 33 2 24 1 181 19.3 7.78 2 24 20069736 1 Met-loss [N-Term] cytosol 85289 ENSG00000198271.4 KRTAP4-5 17 Keratinization 0 High Q9Y3U8 60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3 0 11.346 30 4 24 4 105 12.2 11.59 4 4 4 4 6 7 7 4 8146219.125 16383087 13408874.63 9298954.328 4 4 4 4 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01158 25873 ENSG00000130255.12 RPL36 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62753 40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1 0 18.293 26 8 24 8 249 28.7 10.84 3 6 7 5 4 6 7 7 13956819.19 26921974.56 21571690.88 17607336.88 7 7 7 6 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01092 6194 ENSG00000137154.12 RPS6 9 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; mTORC1-mediated signalling; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome; Insulin signaling pathway; HIF-1 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Proteoglycans in cancer; mTOR signaling pathway; PI3K-Akt signaling pathway 0 High Q9Y224 "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" 0 36.851 40 9 23 9 244 28.1 6.65 3 6 5 6 4 7 5 7 7709750.344 9884100.5 11485249.16 6672181.875 7 6 6 6 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding;RNA binding Pf10036 51637 ENSG00000087302.8 C14orf166; RTRAF 14 tRNA processing in the nucleus 0 High P62979 Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2 0 32.43 54 8 23 3 156 18 9.64 5 4 7 2 6 6 9 2 10672628.22 20250489 35272704.88 20572251.66 7 6 7 7 cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00240, Pf01599, Pf11976, Pf13019, Pf13881, Pf14560" 6233 ENSG00000143947.13 RPS27A 2 "NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Formation of the ternary complex, and subsequently, the 43S complex; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; Ribosomal scanning and start codon recognition; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits" Ribosome 5 High Q15084 Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1 0 32.892 30 7 23 7 440 48.1 5.08 3 3 3 6 3 6 3 11 4521495.703 11049719.06 3817097 12104386.16 4 5 5 7 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 10130 ENSG00000143870.12 PDIA6 2 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High P0DPA2 V-set and immunoglobulin domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VSIG8 PE=2 SV=1 0 61.669 37 9 23 9 414 43.9 7.2 9 23 4341476 4802669.5 68676204.16 1 1 10 membrane Pf07679 391123; 284677 ENSG00000243284.1 VSIG8; C1orf204; SNHG28 1 0 High P39019 40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2 0 19.22 57 9 22 9 145 16.1 10.32 5 6 4 3 5 7 5 5 6405365.875 12233703.72 12040804.59 7917752.484 7 8 8 7 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01090 6223 ENSG00000105372.6 RPS19 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q92888 Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2 0 31.007 15 12 22 12 912 102.4 5.66 12 3 3 16 3 3 112738.5156 12503606.06 4481531.516 4018509.313 1 9 8 7 cell proliferation;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf00621, Pf09128" 9138 ENSG00000076928.17 ARHGEF1 19 G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle Vascular smooth muscle contraction; Pathways in cancer; Proteoglycans in cancer; Regulation of actin cytoskeleton; Platelet activation 0 High Q96HS1 "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" 0 15.9 16 7 22 7 289 32 8.68 5 3 6 4 6 3 7 6 5922125.516 4830331.563 8354014.172 7300045.313 7 6 7 5 cell communication;cell death;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding;signal transducer activity Pf00300 192111 ENSG00000247077.6 PGAM5 12 TNF signaling pathway 0 High P04843 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1 0 36.549 23 12 22 12 607 68.5 6.38 9 8 12 10 254748.1953 1942214.656 19584278.5 16919991.13 2 5 10 9 metabolic process cytosol;endoplasmic reticulum;membrane catalytic activity;protein binding;RNA binding Pf04597 6184 ENSG00000163902.11 RPN1 3 Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q9BYR3 Keratin-associated protein 4-4 OS=Homo sapiens OX=9606 GN=KRTAP4-4 PE=1 SV=1 0 47.812 49 4 22 4 166 18 7.91 4 22 516685607.2 7 Met-loss [N-Term] cytosol 84616 ENSG00000171396.11 KRTAP4-4 17 Keratinization 0 High P69905 Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2 0 17.785 25 4 22 4 142 15.2 8.68 2 2 2 4 4 3 2 13 10037139.44 5424522.875 1833642 243183089.4 4 3 2 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;membrane;organelle lumen antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 3040; 3039 ENSG00000206172.8; ENSG00000188536.12 HBA2; HBA1 16 Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide Malaria; African trypanosomiasis 0 High Q15366 Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1 0 18.753 30 6 22 6 365 38.6 6.79 5 3 5 4 6 4 7 5 6031749.031 15643104.19 11025233.19 12724804.06 6 6 6 5 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 5094 ENSG00000197111.15 PCBP2 12 Negative regulators of DDX58/IFIH1 signaling; mRNA Splicing - Major Pathway 0 High Q00610 Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5 0 24.957 6 9 22 9 1675 191.5 5.69 4 6 6 5 4 7 6 5 4641672.672 8232284.25 5814620.969 4378612.172 8 10 8 8 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole protein binding;RNA binding;structural molecule activity "Pf00637, Pf01394, Pf04053, Pf09268, Pf13838" 1213 ENSG00000141367.11 CLTC 17 "Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle 0 High P31947 14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1 0 27.265 33 8 21 4 248 27.8 4.74 1 3 7 2 1 4 10 6 346793.4375 13820512.13 1 3 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus enzyme regulator activity;protein binding Pf00244 2810 ENSG00000175793.11 SFN 1 Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs Aldosterone-regulated sodium reabsorption; p53 signaling pathway; Cell cycle 0 High P50914 60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4 0 17.562 27 6 21 6 215 23.4 10.93 2 4 5 3 4 6 7 4 11255627.72 24663526.19 18544148.06 13209187.25 6 6 6 5 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01929 9045 ENSG00000188846.13 RPL14 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q13310 Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1 0 27.084 19 10 21 4 644 70.7 9.26 9 4 5 1 9 5 6 1 2396718.813 1349550.258 1609964.289 753122.1016 4 4 4 3 coagulation;metabolic process cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf00658, Pf13893, Pf14259" 8761 ENSG00000090621.13 PABPC4 1 RNA degradation; mRNA surveillance pathway; RNA transport 0 High Q9NV79 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCMTD2 PE=1 SV=2 0 23.062 32 9 21 9 361 41 6.11 4 5 6 4 5 6 6 4 9030753.594 8785492.375 6004252.813 7534509.219 7 7 6 6 Met-loss [N-Term] metabolic process cytoplasm catalytic activity "Pf01135, Pf08242, Pf12847, Pf13847" 55251 ENSG00000280663.4; ENSG00000203880.11 PCMTD2 20; CHR_HSCHR20_1_CTG3 0 High P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3 0 41.783 34 9 21 1 327 37.2 6.19 6 5 5 7 6 8 167346.9219 762932.1875 364921.5938 1 1 1 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf00149 5500 ENSG00000213639.9 PPP1CB 2 Triglyceride catabolism; RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; Regulation of PLK1 Activity at G2/M Transition; Downregulation of TGF-beta receptor signaling; RHO GTPases activate CIT; RHO GTPases activate PKNs; Circadian Clock Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation 0 High P04439 "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" 0 28.265 22 6 21 2 365 40.8 6 1 1 1 6 1 1 2 17 520394.1563 13948559.5 1 2 metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane protein binding;RNA binding "Pf00129, Pf07654" 3105 ENSG00000206503.12 HLA-A 6 "Interferon alpha/beta signaling; E3 ubiquitin ligases ubiquitinate target proteins; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway" 0 High Q9BYR5 Keratin-associated protein 4-2 OS=Homo sapiens OX=9606 GN=KRTAP4-2 PE=1 SV=2 0 43.848 41 2 21 2 136 14.5 7.85 2 21 201469868.1 4 Met-loss [N-Term] cytosol protein binding 85291 ENSG00000244537.2 KRTAP4-2 17 Keratinization 0 High Q8IWF2 FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FOXRED2 PE=1 SV=1 0 32.916 17 10 21 10 684 77.7 7.72 9 7 12 9 12860054.53 15028925.31 10 9 metabolic process endoplasmic reticulum;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf01266, Pf01946, Pf03486, Pf07992, Pf13450, Pf13738" 80020 ENSG00000100350.14 FOXRED2 22 0 High P62910 60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2 0 18.141 41 5 21 5 135 15.9 11.33 3 3 5 2 4 7 8 2 6808412.531 15255999.13 16157798.13 10928848.33 5 5 5 5 Met-loss [N-Term] cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01655 6161 ENSG00000144713.12 RPL32 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9BYU5 Keratin-associated protein 2-1 OS=Homo sapiens OX=9606 GN=KRTAP2-1 PE=2 SV=2 0 49.025 46 3 21 1 128 13.5 7.87 3 21 87438907.38 2 Met-loss [N-Term] cytosol 81872; 728279 ENSG00000262731.3; ENSG00000261852.3; ENSG00000212725.3 KRTAP2-1; KRTAP2-2 17; CHR_HSCHR17_4_CTG4 Keratinization 0 High Q52LG2 Keratin-associated protein 13-2 OS=Homo sapiens OX=9606 GN=KRTAP13-2 PE=1 SV=1 0 58.017 94 11 21 10 175 18.7 8.29 11 21 638716.625 81857586.69 1 12 Met-loss+Acetyl [N-Term] cytosol Pf05287 337959 ENSG00000182816.8 KRTAP13-2 21 Keratinization 2 High Q8NCA5 Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2 0 19.42 15 6 21 4 518 55.2 8.95 4 5 4 2 4 7 5 5 44280090 60620874.34 52916376.41 57801874.58 6 6 7 5 3 High Q8IYB3 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2 0 27.002 9 5 21 5 904 102.3 11.84 5 4 5 3 6 5 7 3 6924139.313 6953187.563 8148845.406 4622759.125 4 5 4 4 metabolic process;transport cytosol;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf01480 10250 ENSG00000133226.16 SRRM1 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway; RNA transport 0 High P49207 60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3 0 8.545 29 5 20 5 117 13.3 11.47 4 5 5 1 6 6 6 2 9194890 17032865.5 18740338.56 12415922 4 4 5 5 cell organization and biogenesis;metabolic process;transport cytosol;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01199 6164 ENSG00000109475.16 RPL34 4 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P31689 DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2 0 24.915 27 8 20 8 397 44.8 7.08 4 6 6 6 7 7 3052220.625 9089279.188 10815723.03 13982232 5 7 8 6 Met-loss [N-Term] cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 3301 ENSG00000086061.15 DNAJA1 9 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High Q14191 Werner syndrome ATP-dependent helicase OS=Homo sapiens OX=9606 GN=WRN PE=1 SV=2 0 35.522 9 14 20 14 1432 162.4 6.34 13 4 16 4 29422966.81 6894942.219 1570474.469 12 10 4 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00270, Pf00271, Pf00570, Pf01612, Pf09382, Pf14493" 7486 ENSG00000165392.9 WRN 8 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates 0 High Q96JN8 Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2 0 39.638 13 14 20 14 1562 166.8 5.86 2 14 1 1 2 16 1 1 2189941.844 16121354 2219787.531 2280496.625 5 9 5 4 Met-loss+Acetyl [N-Term] cytoplasm;cytoskeleton protein binding Pf07177 84461 ENSG00000215041.9 NEURL4 17 0 High P31942 Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2 0 29.396 34 8 20 7 346 36.9 6.87 2 7 7 2 2 8 8 2 3609586.281 19443806.13 19453554.13 8788749.75 5 8 8 5 cell differentiation;metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf14259" 3189 ENSG00000096746.17 HNRNPH3 10 0 High P49327 Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3 0 31.556 6 12 20 12 2511 273.3 6.44 9 1 8 2 9 1 8 2 56854390.48 52883321.83 27237247.5 33283861.19 11 11 11 9 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf00107, Pf00108, Pf00109, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf13602, Pf14765" 2194 ENSG00000169710.8 FASN 17 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism; Activation of gene expression by SREBF (SREBP) Insulin signaling pathway; Fatty acid biosynthesis; AMPK signaling pathway; Metabolic pathways; Fatty acid metabolism 0 High P46777 60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3 0 16.169 19 5 20 5 297 34.3 9.72 3 5 5 3 4 6 6 4 4472426.625 8723827.875 5688869.125 4560519.313 5 5 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00861, Pf14204" 6125 ENSG00000122406.12 RPL5 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9BYR0 Keratin-associated protein 4-7 OS=Homo sapiens OX=9606 GN=KRTAP4-7 PE=1 SV=2 0 12.988 30 2 20 1 210 22.5 7.84 2 20 7832602.5 1 Met-loss [N-Term] cytosol protein binding 100996750 LOC100996750 17 Keratinization 0 High P02545 Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1 0 34.13 26 14 20 14 664 74.1 7.02 13 4 1 15 4 1 986716.4063 16943288.19 3411021.922 2226611.109 4 11 7 7 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf00932" 4000 ENSG00000160789.19 LMNA 1 Signaling by BRAF and RAF fusions; Breakdown of the nuclear lamina; XBP1(S) activates chaperone genes; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Depolymerisation of the Nuclear Lamina; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Apoptosis; Hypertrophic cardiomyopathy (HCM) 0 High P08729 "Keratin, type II cytoskeletal 7 OS=Homo sapiens OX=9606 GN=KRT7 PE=1 SV=5" 0 22.125 9 6 20 2 469 51.4 5.48 3 2 4 2 3 4 9 4 18588692 2 cell death cytoplasm;cytosol;nucleus protein binding;structural molecule activity "Pf00038, Pf12128" 3855 ENSG00000135480.15 KRT7 12 Formation of the cornified envelope 0 High Q9H9G7 Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2 0 29.704 15 10 20 4 860 97.3 9.11 5 9 4 2 5 9 4 2 1455748.469 3683683 1860020.906 1713825.563 2 3 2 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 192669 ENSG00000126070.19 AGO3; EIF2C3 1 Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High P42766 60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2 0 12.154 32 5 20 5 123 14.5 11.05 3 5 4 2 4 7 6 3 7561854.313 12515704.13 10008716 9606370.563 4 5 5 5 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome RNA binding;structural molecule activity Pf00831 11224 ENSG00000136942.14 RPL35 9 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P02042 Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2 0 9.614 22 3 20 3 147 16 8.05 2 1 3 3 1 16 6341983.313 2647944.219 1505724.625 79792005.38 2 2 2 3 coagulation;transport cytosol metal ion binding;protein binding;transporter activity Pf00042 3045 ENSG00000223609.7 HBD 11 Factors involved in megakaryocyte development and platelet production 0 High P31040 "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" 0 26.267 18 9 19 9 664 72.6 7.39 2 7 6 2 2 8 7 2 2931132.031 8312151.531 7080808.266 2857903.984 6 9 9 7 metabolic process;transport membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00890, Pf02910" 6389 ENSG00000073578.16 SDHA 5 Respiratory electron transport; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q8IXB1 DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2 0 15.515 9 7 19 7 793 91 7.18 2 4 7 4 3 4 8 4 4590505.313 5568046.313 7413125.875 5118741.813 6 6 6 5 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00085, Pf00226, Pf13098, Pf13728, Pf13848, Pf13905" 54431 ENSG00000077232.17 DNAJC10 2 Protein processing in endoplasmic reticulum 0 High P51659 Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3 0 19.872 11 7 19 7 736 79.6 8.84 6 2 6 1 9 2 7 1 5276165.875 1574333.078 6256226.375 1423479.586 7 5 7 5 cell differentiation;metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf00106, Pf01575, Pf02036, Pf08659, Pf13452, Pf13561, Pf14864" 3295 ENSG00000133835.14 HSD17B4 5 Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids Peroxisome; Metabolic pathways; Primary bile acid biosynthesis 0 High P42677 40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3 0 11.846 29 2 19 2 84 9.5 9.45 2 2 2 5 5 9 3047105.563 5500104.563 6264430.563 12490050.44 2 3 3 3 cell organization and biogenesis;cell proliferation;metabolic process;transport cytosol;nucleus;ribosome DNA binding;metal ion binding;protein binding;RNA binding;structural molecule activity Pf01667 6232 ENSG00000177954.11 RPS27 1 "Peptide chain elongation; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Separation of Sister Chromatids; SRP-dependent cotranslational protein targeting to membrane; Eukaryotic Translation Termination; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Major pathway of rRNA processing in the nucleolus and cytosol; RHO GTPases Activate Formins; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits" Ribosome 0 High P41252 "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" 0 15.322 6 7 19 7 1262 144.4 6.15 6 4 3 2 7 5 4 3 4416487.063 4194903.25 4129555.563 2751121.094 7 7 6 5 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00133, Pf01406, Pf08264, Pf09334" 3376 ENSG00000196305.17 IARS 9 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High O95819 Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2 0 17.602 7 8 19 8 1239 142 7.46 5 6 5 1 5 8 5 1 3988706.211 7223217.5 4733460.625 2701929.25 7 7 6 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00780, Pf07714" 9448 ENSG00000071054.16 MAP4K4 2 Oxidative Stress Induced Senescence MAPK signaling pathway 0 High Q8NCJ5 SPRY domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SPRYD3 PE=1 SV=2 0 21.045 27 10 19 10 442 49.7 6.16 6 7 4 7 8 4 275738.4609 10050928.72 11869835.38 8338097.156 2 9 9 8 protein binding Pf00622 84926 ENSG00000167778.8 SPRYD3 12 0 High P98160 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4 0 34.073 5 15 19 15 4391 468.5 6.51 4 14 1 4 14 1 3837852.25 9357519.156 2514429.141 3495821.563 9 13 9 6 cell differentiation;cell growth;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen metal ion binding;protein binding "Pf00008, Pf00047, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf07686, Pf12785, Pf13385, Pf13895, Pf13927" 3339 ENSG00000142798.17 HSPG2 1 "Integrin cell surface interactions; Defective B4GALT7 causes EDS, progeroid type; Amyloid fiber formation; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Non-integrin membrane-ECM interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD" Hepatitis B; Proteoglycans in cancer; ECM-receptor interaction 0 High P18621 60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3 0 33.181 46 7 18 7 184 21.4 10.17 3 4 6 1 3 4 10 1 10168244.53 15641131.94 17587438.5 7592463.813 7 7 9 5 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00237 6139 ENSG00000215472.10; ENSG00000265681.7 RPL17 18 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P05023 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1 0 36.935 14 11 18 11 1023 112.8 5.49 7 9 8 10 1421439.805 1745465.531 7261441.406 12340437.06 5 3 8 8 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 476 ENSG00000163399.15 ATP1A1 1 Ion homeostasis; Ion transport by P-type ATPases Bile secretion; cGMP-PKG signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Protein digestion and absorption; Proximal tubule bicarbonate reclamation; Thyroid hormone signaling pathway; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Pancreatic secretion; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Gastric acid secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Mineral absorption 0 High P52292 Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1 0 19.294 11 5 18 5 529 57.8 5.4 4 1 4 5 5 2 4 7 2478269.75 2096905.391 3687627.594 4025748.563 5 5 4 5 metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;transporter activity "Pf00514, Pf01749, Pf13513, Pf13646" 3838 ENSG00000182481.8 KPNA2 17 ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Sensing of DNA Double Strand Breaks Influenza A 0 High P61313 60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2 0 14.721 29 7 18 7 204 24.1 11.62 2 4 5 5 2 4 7 5 6952173.813 14699004.13 13863579.25 9606343.688 5 7 7 6 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00827 6138 ENSG00000174748.18 RPL15 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P62266 40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3 0 17.073 42 6 18 6 143 15.8 10.49 3 4 3 4 4 4 5 5 8565834.375 12691526.13 12874959.5 8908805.531 3 3 3 4 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00164 6228 ENSG00000186468.12 RPS23 5 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P23526 Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4 0 17.844 15 6 18 6 432 47.7 6.34 5 4 4 3 6 4 5 3 5546593.563 5445360.875 5622164.469 4811954.438 5 5 5 5 defense response;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00670, Pf02254, Pf02826, Pf05221" 191 ENSG00000101444.12 AHCY 20 "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD); Sulfur amino acid metabolism; Methylation" Metabolic pathways; Cysteine and methionine metabolism 0 High Q01081 Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3 0 16.27 15 4 18 4 240 27.9 8.81 3 2 4 2 4 3 9 2 5399862.594 3956298.406 6446152.438 3692188.047 5 4 5 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;transport nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00076, Pf00642, Pf13893" 7307; 102724594 ENSG00000160201.11; ENSG00000275895.6 U2AF1; LOC102724594; U2AF1L5 21 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Shigellosis 0 High Q96PK6 RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2 0 24.589 17 8 18 8 669 69.4 9.67 3 3 7 4 3 3 8 4 2752849.719 3695210.5 5484318.063 3442895.234 5 7 6 5 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10432; 100526737 ENSG00000239306.4 RBM14; RBM14-RBM4 11 RUNX2 regulates bone development 0 High Q9BYR8 Keratin-associated protein 3-1 OS=Homo sapiens OX=9606 GN=KRTAP3-1 PE=1 SV=1 0 17.166 28 3 18 3 98 10.5 6.4 3 18 525330150 5 Acetyl [N-Term] cytosol protein binding;structural molecule activity Pf04579 83896 ENSG00000212901.3; ENSG00000262068.3 KRTAP3-1 17; CHR_HSCHR17_4_CTG4 Keratinization 0 High Q86SJ6 Desmoglein-4 OS=Homo sapiens OX=9606 GN=DSG4 PE=1 SV=1 0 40.481 17 13 18 13 1040 113.8 4.56 13 18 462640.4375 23376925.88 159005.7969 1 7 1 cell death;cell differentiation;regulation of biological process;response to stimulus cytoskeleton;membrane metal ion binding "Pf00028, Pf01049" 147409 ENSG00000175065.11 DSG4 18 Formation of the cornified envelope 0 High P51531 Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2 0 24.176 6 9 18 1 1590 181.2 7.2 6 5 3 3 6 5 3 4 627041.9375 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoskeleton;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619" 6595 ENSG00000080503.22 SMARCA2 9 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High P28288 ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1 0 36.095 27 14 18 14 659 75.4 9.36 14 3 15 3 275182.3164 832517.5 10950901.02 4131614.328 2 1 11 8 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf06472" 5825 ENSG00000117528.11 ABCD3 1 ABC transporters in lipid homeostasis Peroxisome; ABC transporters 0 High P46776 60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2 0 18.383 26 4 18 4 148 16.6 11 2 4 4 2 2 6 6 4 10284290.5 16213578.25 17652111.38 13273365.19 4 4 4 4 cell organization and biogenesis;metabolic process;transport cytosol;endoplasmic reticulum;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00828 6157 ENSG00000166441.12 RPL27A 11 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q93034 Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4 0 17.747 10 8 17 8 780 90.9 7.94 4 7 2 2 4 9 2 2 5635463.313 13510730.44 2519201.172 4351080.078 7 8 5 6 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytosol;nucleus catalytic activity;protein binding;receptor activity;transporter activity "Pf00888, Pf10557" 8065 ENSG00000166266.13 CUL5 11 Downregulation of ERBB2 signaling; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High O14654 Insulin receptor substrate 4 OS=Homo sapiens OX=9606 GN=IRS4 PE=1 SV=1 0 23.469 11 9 17 9 1257 133.7 8.44 3 3 5 6 3 3 5 6 3349126.875 4620466.457 5254393.617 4957098.516 7 8 7 7 regulation of biological process;response to stimulus cytosol;membrane protein binding;signal transducer activity "Pf00169, Pf02174" 8471 ENSG00000133124.11 IRS4 X IRS-related events triggered by IGF1R Longevity regulating pathway - multiple species; Insulin signaling pathway; FoxO signaling pathway; cGMP-PKG signaling pathway; Type II diabetes mellitus; AMPK signaling pathway; Regulation of lipolysis in adipocytes; Adipocytokine signaling pathway; Longevity regulating pathway 0 High Q9BYR9 Keratin-associated protein 2-4 OS=Homo sapiens OX=9606 GN=KRTAP2-4 PE=1 SV=1 0 38.303 46 3 17 1 128 13.5 7.87 3 17 569318216.4 4 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol protein binding 85294; 730755 ENSG00000212724.3; ENSG00000213417.3; ENSG00000262862.2; ENSG00000263091.2 KRTAP2-4; KRTAP2-3 17; CHR_HSCHR17_4_CTG4 Keratinization 3 High Q96MG8 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PCMTD1 PE=1 SV=2 0 11.572 17 6 17 6 357 40.7 5.66 3 6 3 2 3 7 4 3 3831960.688 8470123.625 3785549.375 3225892.469 4 4 4 4 metabolic process cytoplasm;membrane catalytic activity "Pf01135, Pf12847, Pf13847" 115294 ENSG00000168300.13 PCMTD1 8 0 High Q15287 RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1 0 15.067 14 4 17 4 305 34.2 11.84 3 2 2 3 4 4 4 5 10627169.19 9757684 9981985 3850218.25 3 2 2 2 metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf11608, Pf13893, Pf14259" 10921 ENSG00000205937.11 RNPS1 16 mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High Q9HCM4 Band 4.1-like protein 5 OS=Homo sapiens OX=9606 GN=EPB41L5 PE=1 SV=3 0 23.84 18 9 17 8 733 81.8 6.58 5 6 4 2 5 6 4 2 4813809.281 7014942.344 6217773.625 3244025.891 8 8 8 5 cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 57669 ENSG00000115109.13 EPB41L5 2 Neurexins and neuroligins 1 High Q13228 Methanethiol oxidase OS=Homo sapiens OX=9606 GN=SELENBP1 PE=1 SV=2 0 45.631 36 13 17 13 472 52.4 6.37 13 17 25568578 18200898 45218334.22 14334521 1 1 12 1 transport cytoplasm;cytosol;membrane;nucleus protein binding "Pf05694, Pf10282" 8991 ENSG00000143416.20 SELENBP1 1 0 High Q8IUC1 Keratin-associated protein 11-1 OS=Homo sapiens OX=9606 GN=KRTAP11-1 PE=1 SV=1 0 30.563 28 6 17 6 163 17.1 7.9 6 17 1662372.594 2236583 181286809.9 5429953 2 1 11 1 Met-loss+Acetyl [N-Term] cytosol structural molecule activity Pf05287 337880 ENSG00000182591.5 KRTAP11-1 21 Keratinization 0 High P27635 60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4 0 25.349 37 7 17 7 214 24.6 10.08 2 6 4 2 2 7 6 2 5825335.5 15873121.63 15052934.88 7933263.781 5 5 4 5 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity;translation regulator activity Pf00252 6134 RPL10 X Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O94898 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens OX=9606 GN=LRIG2 PE=2 SV=3 0 29.894 9 8 17 8 1065 118.9 5.55 4 8 4 13 7237443.219 11353786.47 7 8 regulation of biological process cytoplasm;membrane protein binding "Pf00047, Pf07679, Pf07686, Pf12799, Pf13306, Pf13855, Pf13895, Pf13927" 9860 ENSG00000198799.11 LRIG2 1 0 High P62937 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2 0 18.742 28 5 17 5 165 18 7.81 2 4 5 1 2 5 9 1 2948450.344 5637554.531 13792712.5 958722.4844 5 5 5 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 5478 ENSG00000196262.13 PPIA 7 Budding and maturation of HIV virion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Minus-strand DNA synthesis; Binding and entry of HIV virion; Basigin interactions; APOBEC3G mediated resistance to HIV-1 infection; Uncoating of the HIV Virion; Calcineurin activates NFAT; Platelet degranulation ; Plus-strand DNA synthesis; Integration of provirus; Neutrophil degranulation; Assembly Of The HIV Virion; Interleukin-12 family signaling 0 High Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog OS=Homo sapiens OX=9606 GN=TAPT1 PE=1 SV=1 0 27.818 24 9 17 9 567 64.2 8.28 9 2 15 2 978241.9375 18755612.75 1372584.406 2486515.766 1 8 4 6 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane receptor activity;signal transducer activity Pf05346 202018 ENSG00000169762.16 TAPT1 4 0 High Q5M9Q1 NKAP-like protein OS=Homo sapiens OX=9606 GN=NKAPL PE=1 SV=3 0 10.014 11 5 17 1 402 46.3 9.72 1 5 5 3 1 6 6 4 1169224.875 999616.9375 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus nucleus Pf06047 222698 ENSG00000189134.3 NKAPL 6 0 High P62987 Ubiquitin-60S ribosomal protein L40 OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2 0 17.806 48 6 16 1 128 14.7 9.83 4 3 4 2 5 4 5 2 918232.5 929334.875 671028.0625 1 1 1 cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;structural molecule activity "Pf00240, Pf01020, Pf11976, Pf13019, Pf13881, Pf14560" 7311 ENSG00000221983.7 UBA52 19 "NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits" Ribosome 0 High P45880 Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2 0 36.938 37 9 16 9 294 31.5 7.56 9 3 13 3 827420.3906 693946.625 37681615.88 5081747 3 2 8 4 regulation of biological process;transport membrane;mitochondrion;nucleus nucleotide binding;protein binding;transporter activity Pf01459 7417 ENSG00000165637.13 VDAC2 10 Mitochondrial calcium ion transport; Ub-specific processing proteases NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High Q92925 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3 0 10.597 11 5 16 3 531 58.9 9.64 4 3 1 4 6 4 1 5 4236034.188 4909373 3810239.25 2982619 5 5 5 4 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf02201 6603 ENSG00000108604.15 SMARCD2 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 2 High P62851 40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1 0 10.287 16 3 16 3 125 13.7 10.11 3 3 2 3 4 4 3 5 10224388.81 19048679.5 13498902.55 12752365.86 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytosol;nucleus;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity Pf03297 6230 ENSG00000280831.2; ENSG00000118181.10 RPS25 11; CHR_HG2217_PATCH "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P60866 40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1 0 10.093 25 3 16 3 119 13.4 9.94 2 1 3 2 3 3 5 5 4372362.414 11146928.56 9986192.281 7378806.656 3 3 3 3 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00338 6224 ENSG00000008988.9 RPS20 8 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P84103 Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1 0 15.175 35 4 16 4 164 19.3 11.65 3 3 2 3 4 5 3 4 3974363.547 6249483.25 6997022.375 5416161.5 3 3 3 4 metabolic process;regulation of biological process;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6428 ENSG00000112081.16 SRSF3 6 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 0 High Q9BYR4 Keratin-associated protein 4-3 OS=Homo sapiens OX=9606 GN=KRTAP4-3 PE=2 SV=2 0 41.803 56 3 16 3 195 20.5 7.94 3 16 107812867.5 4 Met-loss [N-Term]; Acetyl [N-Term] cytosol 85290 ENSG00000196156.4 KRTAP4-3 17 Keratinization 0 High P46779 60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3 0 10.337 23 4 16 4 137 15.7 12.02 1 4 3 2 2 6 4 4 5650729.375 11104259.44 9819661.234 9292765.25 3 4 4 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01778 6158 ENSG00000108107.14 RPL28 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q99567 Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2 0 22.497 19 9 15 9 741 83.5 5.69 5 4 4 5 4 6 917756.1875 5399024.375 6866379.406 5706032.5 1 5 6 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytosol;nucleus protein binding;transporter activity "Pf02050, Pf07767, Pf09789, Pf10168" 4927 ENSG00000108559.11 NUP88 17 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q13151 Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1 0 12.594 17 4 15 3 305 30.8 9.29 3 4 4 3 3 5 4 3 2955813.688 4325782.813 5364617.875 2324596.75 3 3 3 3 defense response;metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10949 ENSG00000177733.6 HNRNPA0 5 mRNA Splicing - Major Pathway 0 High P04844 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3 0 31.261 22 8 15 8 631 69.2 5.69 1 3 7 1 3 11 2351726.5 3471700.938 5155623.375 13259789.72 1 2 7 9 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;protein binding Pf05817 6185 ENSG00000118705.16 RPN2 20 Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q99497 Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2 0 10.773 24 4 15 4 189 19.9 6.79 3 4 4 3 3 5 4 3 3283051.219 5720468.438 4522591 3858368.844 4 4 4 4 cell communication;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding "Pf01965, Pf13278" 11315 ENSG00000116288.12 PARK7 1 Parkinson's disease 0 High Q8IUC0 Keratin-associated protein 13-1 OS=Homo sapiens OX=9606 GN=KRTAP13-1 PE=2 SV=2 0 46.552 96 7 15 6 172 18.3 8.12 7 15 5725635.5 33859219 1 5 Met-loss+Acetyl [N-Term] cytosol Pf05287 140258 ENSG00000198390.4 KRTAP13-1 21 Keratinization 0 High Q14008 Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3 0 25.845 7 11 15 11 2032 225.4 7.8 11 2 1 12 2 1 2850943.75 10284163.59 5070359.391 2411659.938 6 9 8 4 cell division;cell organization and biogenesis;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane protein binding Pf12348 9793 ENSG00000175216.14 CKAP5 11 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins 0 High P21333 Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4 0 22.007 4 7 15 7 2647 280.6 6.06 1 6 6 2 1 6 6 2 936418.2813 2505853.281 2298474.813 2209953.125 4 5 6 6 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus protein binding;RNA binding;signal transducer activity "Pf00307, Pf00630" 2316 ENSG00000196924.14 FLNA X Platelet degranulation ; RHO GTPases activate PAKs; Cell-extracellular matrix interactions; GP1b-IX-V activation signalling MAPK signaling pathway; Focal adhesion; Proteoglycans in cancer; Salmonella infection 0 High Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2 0 19.603 16 8 15 8 557 64.1 5.08 5 4 5 6 4 5 7591560.906 6283708.563 3516600.281 8 7 5 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf01485 25820 ENSG00000166233.14 ARIH1 15 ISG15 antiviral mechanism 0 High Q04837 "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" 0 14.735 24 4 15 4 148 17.2 9.6 4 3 3 6 5 4 592222.0703 15953583.75 9982747.25 6566053.688 2 4 4 4 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen DNA binding;protein binding;RNA binding Pf00436 6742 ENSG00000106028.10 SSBP1 7 Transcriptional activation of mitochondrial biogenesis Homologous recombination; DNA replication; Mismatch repair 0 High P18077 60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2 0 9.138 32 4 15 4 110 12.5 11.06 2 4 3 4 2 6 3 4 7629936.375 15158282.5 12876340.75 6716023.25 4 4 4 3 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01247 6165 ENSG00000182899.14 RPL35A 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P01889 "HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" 0 34.15 40 10 15 5 362 40.4 5.85 1 10 1 14 61939192 67515427.14 48948691.52 48038892.25 1 3 3 6 regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;Golgi;membrane protein binding "Pf00129, Pf06623, Pf07654" 3106 ENSG00000234745.10 HLA-B 6 "Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation 1 High P17931 Galectin-3 OS=Homo sapiens OX=9606 GN=LGALS3 PE=1 SV=5 0 26.395 28 6 15 6 250 26.1 8.56 6 15 292130.4063 460543.0938 35949812.38 338686.875 1 2 7 1 cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf00337 3958 ENSG00000131981.15 LGALS3 14 RUNX2 regulates genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 0 High Q01844 RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1 0 23.583 11 4 15 4 656 68.4 9.33 3 1 4 2 4 2 6 3 9638894.063 8393414.625 12007738.81 4564343.391 4 4 4 4 metabolic process;regulation of biological process cytoplasm;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf14259" 2130 ENSG00000182944.17 EWSR1 22 Transcriptional misregulation in cancer 0 High P46977 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens OX=9606 GN=STT3A PE=1 SV=2 0 18.21 13 9 15 8 705 80.5 8.07 3 8 3 12 233360.5781 1349796.672 3757252.141 12023338.92 1 5 7 9 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf02516 3703 ENSG00000134910.12 STT3A 11 Asparagine N-linked glycosylation N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 1 High Q13427 Peptidyl-prolyl cis-trans isomerase G OS=Homo sapiens OX=9606 GN=PPIG PE=1 SV=2 0 7.958 5 5 15 5 754 88.6 10.29 4 3 4 2 5 4 4 2 2623963.371 3197874.094 3827699.078 2137515.689 5 5 5 4 metabolic process cytosol;nucleus catalytic activity;protein binding;RNA binding Pf00160 9360 ENSG00000138398.15 PPIG 2 0 High Q96RR1 "Twinkle protein, mitochondrial OS=Homo sapiens OX=9606 GN=TWNK PE=1 SV=1" 0 26.008 14 8 15 8 684 77.1 8.98 8 3 12 3 772276.625 11197310.25 2012247.5 3788369.781 1 6 4 5 cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus mitochondrion;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding "Pf03796, Pf13401, Pf13476, Pf13481" 56652 ENSG00000107815.7 C10orf2; TWNK 10 Transcriptional activation of mitochondrial biogenesis 0 High O15078 Centrosomal protein of 290 kDa OS=Homo sapiens OX=9606 GN=CEP290 PE=1 SV=2 0 26.751 6 12 14 12 2479 290.2 5.95 11 3 11 3 910106.3398 5643873.953 3023945.234 1665085.438 6 10 7 4 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen protein binding 80184 ENSG00000198707.14 CEP290 12 Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High Q969G3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2 0 16.932 20 5 14 5 411 46.6 4.88 3 3 3 1 4 4 3 3 3494687 5667989.063 3320207 3425934.938 4 4 3 3 cell differentiation;cell organization and biogenesis;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf00505 6605 ENSG00000073584.18 SMARCE1 17 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High P04637 Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4 0 7.644 12 5 14 5 393 43.6 6.79 2 4 3 2 3 4 4 3 3968961.797 3774719.125 2853020.313 1720590.727 5 5 4 4 cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00870, Pf07710, Pf08563" 7157 ENSG00000141510.16 TP53 17 TP53 Regulates Transcription of Caspase Activators and Caspases; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Ovarian tumor domain proteases; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Factors involved in megakaryocyte development and platelet production; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Regulation of TP53 Expression; Regulation of TP53 Activity through Phosphorylation; Transcriptional activation of cell cycle inhibitor p21 ; Pre-NOTCH Transcription and Translation; The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M DNA damage checkpoint; Ub-specific processing proteases; PI5P Regulates TP53 Acetylation; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Methylation; Activation of NOXA and translocation to mitochondria; Association of TriC/CCT with target proteins during biosynthesis; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Interleukin-4 and 13 signaling; Formation of Senescence-Associated Heterochromatin Foci (SAHF); TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Oxidative Stress Induced Senescence; RUNX3 regulates CDKN1A transcription Viral carcinogenesis; Hepatitis B; Central carbon metabolism in cancer; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Epstein-Barr virus infection; Neurotrophin signaling pathway; Huntington's disease; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; Glioma; Melanoma; HTLV-I infection; Apoptosis; Wnt signaling pathway; Proteoglycans in cancer; Transcriptional misregulation in cancer; p53 signaling pathway; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS); Thyroid cancer; Hepatitis C; Cell cycle; Endocrine resistance; Basal cell carcinoma; Longevity regulating pathway; PI3K-Akt signaling pathway; Platinum drug resistance 0 High P32119 Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5 0 13.142 26 5 14 4 198 21.9 5.97 2 2 4 2 3 2 6 3 1609606.813 2013620.625 4286516.563 3786265.969 2 2 3 2 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 7001 ENSG00000167815.11 PRDX2 19 TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species 0 High P62993 Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1 0 15.671 33 5 14 5 217 25.2 6.32 1 4 4 4 1 4 4 5 754557.3125 4107131.438 5978074 4713633.844 2 4 4 5 cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;Golgi;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00017, Pf00018, Pf07653, Pf14604" 2885 ENSG00000177885.13 GRB2 17 "PI3K Cascade; SHC-mediated cascade:FGFR4; Signaling by FGFR4 in disease; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; Signal regulatory protein family interactions; EGFR downregulation; SHC1 events in ERBB4 signaling; NCAM signaling for neurite out-growth; DAP12 signaling; PI-3K cascade:FGFR4; GRB2 events in EGFR signaling; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Constitutive Signaling by EGFRvIII; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin receptor SHC signaling; MET receptor recycling; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; Negative regulation of MET activity; FRS-mediated FGFR2 signaling; CD28 dependent Vav1 pathway; Signalling to RAS; GPVI-mediated activation cascade; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; RET signaling; SHC-mediated cascade:FGFR1; GRB2 events in ERBB2 signaling; PI-3K cascade:FGFR1; PI3K events in ERBB2 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; RAF/MAP kinase cascade; Tie2 Signaling; FCERI mediated Ca+2 mobilization; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; MET activates RAP1 and RAC1; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; MET activates RAS signaling; MET activates PTPN11; Signal attenuation; SHC-mediated cascade:FGFR2; EGFR Transactivation by Gastrin; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; SOS-mediated signalling; Interleukin-20 family signaling; Interleukin-15 signaling; Spry regulation of FGF signaling; Cargo recognition for clathrin-mediated endocytosis; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SHC1 events in EGFR signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; RHO GTPases Activate WASPs and WAVEs; Regulation of KIT signaling; GAB1 signalosome; InlB-mediated entry of Listeria monocytogenes into host cell" Viral carcinogenesis; T cell receptor signaling pathway; Dorso-ventral axis formation; Osteoclast differentiation; Hepatitis B; Insulin signaling pathway; FoxO signaling pathway; Prolactin signaling pathway; MicroRNAs in cancer; Phospholipase D signaling pathway; Chronic myeloid leukemia; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Natural killer cell mediated cytotoxicity; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Glioma; Gap junction; Renal cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Focal adhesion; Jak-STAT signaling pathway; Proteoglycans in cancer; Choline metabolism in cancer; mTOR signaling pathway; Fc epsilon RI signaling pathway; Hepatitis C; Alcoholism; Ras signaling pathway; Endocrine resistance; GnRH signaling pathway; Chemokine signaling pathway; Signaling pathways regulating pluripotency of stem cells; Estrogen signaling pathway; PI3K-Akt signaling pathway 0 High B5ME19 Eukaryotic translation initiation factor 3 subunit C-like protein OS=Homo sapiens OX=9606 GN=EIF3CL PE=1 SV=1 0 22.604 10 7 14 7 914 105.4 5.64 3 6 2 2 3 7 2 2 1281730.578 5267561.688 1713788.609 1363208.016 3 6 4 4 metabolic process cytoplasm protein binding;RNA binding "Pf01399, Pf05470" 728689 ENSG00000205609.12 EIF3CL 16 RNA transport 0 High Q92785 Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2 0 21.761 25 7 14 7 391 44.1 6.33 4 5 1 3 5 5 1 3 3443044.813 12546142 2686542.469 2622756.938 5 6 5 4 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;metal ion binding;protein binding "Pf00628, Pf14051" 5977 ENSG00000133884.9 DPF2 11 0 High Q02543 60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2 0 18.806 32 6 14 6 176 20.7 10.71 1 4 5 3 1 4 5 4 11510058.06 21701199.31 18531194.44 12512398.38 3 6 6 4 cell organization and biogenesis;metabolic process;response to stimulus;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01775 6142 ENSG00000105640.12 RPL18A 19 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q52LJ0 Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2 0 12.78 14 5 14 3 433 45.5 8.69 4 4 3 1 4 6 3 1 1794916.625 1683313.125 1683762.625 1146776.75 3 2 2 2 0 High Q9Y230 RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3 0 9.768 16 6 14 6 463 51.1 5.64 6 2 2 4 6 2 2 4 2847349.531 2069984.922 2574568.266 2525050.578 5 5 5 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03796, Pf06068, Pf13481" 10856 ENSG00000183207.13 RUVBL2 19 HATs acetylate histones; Telomere Extension By Telomerase 0 High Q96I24 Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2 0 19.831 14 6 14 6 572 61.6 8.38 2 6 5 1 2 6 5 1 1137191.25 3869532.75 2084156.844 1065356.109 4 5 4 3 metabolic process;regulation of biological process cytoplasm;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf07650, Pf13014" 8939 ENSG00000107164.15 FUBP3 9 0 High Q9BYP7 Serine/threonine-protein kinase WNK3 OS=Homo sapiens OX=9606 GN=WNK3 PE=1 SV=3 0 23.403 5 9 14 9 1800 198.3 6.07 8 4 1 9 4 1 7334707.625 2602390.75 664660.7813 7 4 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12202" 65267 ENSG00000196632.10 WNK3 X Stimuli-sensing channels 0 High O95232 Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2 0 19.563 13 5 14 5 432 51.4 9.79 4 4 1 4 4 4 1 5 4509452.281 4429932.844 5524187.25 5084743.391 4 4 4 4 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf03194 51747 ENSG00000108848.15 LUC7L3 17 0 High Q8TCT9 Minor histocompatibility antigen H13 OS=Homo sapiens OX=9606 GN=HM13 PE=1 SV=1 0 25.504 15 4 14 4 377 41.5 6.43 4 1 11 3 25873335.06 2103267.563 4 4 cell organization and biogenesis;metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity;protein binding "Pf04258, Pf06550" 81502 ENSG00000101294.16 HM13 20 0 High Q9UMS4 Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1 0 11.583 11 3 14 3 504 55.1 6.61 3 3 3 1 4 4 5 1 2348486.688 2544859.563 2728681.125 1715346.719 3 3 3 3 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex catalytic activity;metal ion binding;protein binding "Pf00400, Pf04564, Pf08606, Pf11789" 27339 ENSG00000110107.8 PRPF19 11 Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Spliceosome 0 High Q5SNT2 Transmembrane protein 201 OS=Homo sapiens OX=9606 GN=TMEM201 PE=1 SV=1 0 25.383 22 9 14 9 666 72.2 9.22 9 1 13 1 50515.85938 352072.5313 19656814.3 2950046.813 1 1 7 3 Acetyl [N-Term] cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton;membrane;nucleus protein binding "Pf09779, Pf10476" 199953 ENSG00000188807.12 TMEM201 1 0 High P50991 T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4 0 22.473 18 7 14 7 539 57.9 7.83 2 1 5 4 2 2 6 4 885255.2891 1499940.891 3348269.031 3141430.125 3 4 5 4 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 10575 ENSG00000115484.14 CCT4 2 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q9HC44 Vasculin-like protein 1 OS=Homo sapiens OX=9606 GN=GPBP1L1 PE=1 SV=1 0 2.539 1 1 14 1 474 52.3 6.84 1 1 1 7 2 5 167731.7188 21328623 10365769 13396865.38 1 2 2 2 metabolic process;regulation of biological process nucleus DNA binding Pf15337 60313 ENSG00000159592.10 GPBP1L1 1 0 High Q86YZ3 Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2 0 22.232 8 6 13 6 2850 282.2 10.04 3 6 1 2 3 7 1 2 2206659.188 12631353.5 7414232.313 4289239.125 3 4 4 2 cell organization and biogenesis;development;transport cytoplasm;cytoskeleton;extracellular;nucleus;organelle lumen metal ion binding 388697 ENSG00000197915.5 HRNR 1 Neutrophil degranulation 0 High Q8TEM1 Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3 0 20.813 4 7 13 7 1887 205 6.81 1 4 7 1 4 8 402418.4375 473217.125 3759888.469 6089617.844 2 2 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;nucleus protein binding Pf02368 23225 ENSG00000132182.11 NUP210 3 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P27482 Calmodulin-like protein 3 OS=Homo sapiens OX=9606 GN=CALML3 PE=1 SV=2 0 26.506 58 5 13 5 149 16.9 4.42 5 13 130246.3359 1416720.953 72595981.5 1212017.75 1 2 6 1 metal ion binding;protein binding "Pf00036, Pf08726, Pf13202, Pf13405, Pf13499, Pf13833" 810 ENSG00000178363.4 CALML3 10 Dopaminergic synapse; Phototransduction; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Renin secretion; Neurotrophin signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; Long-term potentiation; Glioma; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Pertussis; Melanogenesis; Alzheimer's disease; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; Alcoholism; Ras signaling pathway; GnRH signaling pathway; cAMP signaling pathway; Estrogen signaling pathway; Calcium signaling pathway 0 High Q6A162 "Keratin, type I cytoskeletal 40 OS=Homo sapiens OX=9606 GN=KRT40 PE=1 SV=2" 0 16.086 10 5 13 1 431 48.1 4.41 5 13 1532085.375 1 cell death;regulation of biological process cytosol catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf05557, Pf07888, Pf13514" 125115 ENSG00000262845.7; ENSG00000204889.10 KRT40 17; CHR_HSCHR17_4_CTG4 Formation of the cornified envelope 0 High O43684 Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1 0 22.641 25 6 13 6 328 37.1 6.84 2 2 4 3 2 2 5 4 946602.75 1946641.781 4045159.313 3849259.5 2 3 4 4 cell division;cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytosol;nucleus protein binding "Pf00400, Pf04762" 9184 ENSG00000154473.17 BUB3 10 Inactivation of APC/C via direct inhibition of the APC/C complex; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A HTLV-I infection; Cell cycle 0 High P06576 "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" 0 25.388 16 6 13 6 529 56.5 5.4 1 2 5 3 1 2 7 3 905366.9063 1176340.75 5937350.688 2778430 3 4 6 6 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cell surface;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00006, Pf00306, Pf02874" 506 ENSG00000110955.8 ATP5B 12 Transcriptional activation of mitochondrial biogenesis; Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways 0 High P46778 60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2 0 13.196 22 5 13 5 160 18.6 10.49 3 3 5 2 3 3 5 2 5376742.344 9549924.281 12850338.19 7966994.563 5 5 5 4 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01157 6144 ENSG00000122026.10 RPL21 13 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8NEZ5 F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1 0 26.081 22 7 13 7 403 44.5 7.03 1 7 4 1 8 4 2306479.547 6116635.563 4707193.531 4 4 5 cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00646, Pf10442, Pf12937" 26263 ENSG00000167196.13 FBXO22 15 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q9P258 Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2 0 17.879 16 6 13 6 522 56 8.78 1 2 5 4 1 2 6 4 299894.6563 7613749.234 2747133.406 3940833.594 2 4 4 4 cell division;cell organization and biogenesis;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding "Pf00415, Pf13540" 55920 ENSG00000281540.2; ENSG00000179051.13 RCC2 1; CHR_HG2095_PATCH Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins 0 High Q9UHX1 Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1 0 11.57 14 5 13 5 559 59.8 5.29 3 2 3 3 3 2 4 4 2472609.688 1734170.438 2917054.063 3500137.875 3 3 3 3 cell death;cellular homeostasis;metabolic process;regulation of biological process nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22827 ENSG00000274081.4; ENSG00000179950.13 PUF60 8; CHR_HSCHR8_3_CTG7 mRNA Splicing - Major Pathway Spliceosome 0 High Q16585 Beta-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCB PE=1 SV=1 0 37.942 43 8 13 8 318 34.8 8.62 8 13 248890.2969 14231798.94 1 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;membrane Pf04790 6443 ENSG00000163069.12 SGCB 4 Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Viral myocarditis; Hypertrophic cardiomyopathy (HCM) 0 High P25205 DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3 0 25.106 15 9 13 9 808 90.9 5.77 1 1 3 7 1 1 4 7 2788521.516 3244470.703 4211427.297 7788196.063 4 4 5 8 metabolic process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf01078, Pf07728, Pf14551" 4172 ENSG00000112118.18 MCM3 6 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q969N2 GPI transamidase component PIG-T OS=Homo sapiens OX=9606 GN=PIGT PE=1 SV=1 0 15.253 10 5 13 5 578 65.7 8.38 5 4 7 6 180347.9844 13959751.63 4812280.781 1 5 4 cell death;cell differentiation;metabolic process cytoplasm;endoplasmic reticulum;membrane catalytic activity;protein binding Pf04113 51604 ENSG00000124155.17 PIGT 20 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High Q9NZI8 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2 0 14.279 15 7 13 7 577 63.4 9.2 4 3 4 2 4 3 4 2 2987300.406 5074822.094 6507208.828 1662682.125 4 6 8 2 cell proliferation;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf00076, Pf13014, Pf13893, Pf14259" 10642 ENSG00000159217.9 IGF2BP1 17 MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MicroRNAs in cancer 0 High Q9Y597 BTB/POZ domain-containing protein KCTD3 OS=Homo sapiens OX=9606 GN=KCTD3 PE=1 SV=2 0 21.918 17 10 13 10 815 88.9 7.03 10 13 12646946.55 92186.55469 9 1 cell organization and biogenesis membrane protein binding Pf02214 51133 ENSG00000136636.12 KCTD3 1 0 High O43143 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2 0 10.707 6 5 12 5 795 90.9 7.46 3 4 3 2 3 4 3 2 2296091.188 4375581.688 3978476.969 2326189.469 5 5 5 4 metabolic process;response to stimulus cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 1665 ENSG00000109606.12 DHX15 4 mRNA Splicing - Major Pathway Spliceosome 0 High P84098 60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1 0 13.734 28 6 12 6 196 23.5 11.47 3 2 4 2 4 2 4 2 6414891.563 13177335.44 13525951.63 8765545.969 5 5 4 4 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01280 6143 ENSG00000108298.9 RPL19 17 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q14697 Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3 0 17.824 7 6 12 6 944 106.8 6.14 3 6 3 9 163067.7188 811432.7813 3615234.406 7074900.625 1 3 6 6 metabolic process endoplasmic reticulum;Golgi;membrane;organelle lumen catalytic activity;RNA binding "Pf01055, Pf13802" 23193 ENSG00000089597.16 GANAB 11 Calnexin/calreticulin cycle N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q96AG4 Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1 0 12.908 15 4 12 4 307 34.9 9.57 3 4 4 4 4 4 4835869.75 4679291.5 4200181.938 1451947.5 3 3 3 1 endoplasmic reticulum;membrane;nucleus protein binding;RNA binding "Pf12799, Pf13855" 55379 ENSG00000108829.9 LRRC59 17 0 High Q9Y4L1 Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1 0 19.759 9 7 12 7 999 111.3 5.22 5 6 5 7 62927.69141 226539.5 4908655.938 6758917.844 1 2 6 7 regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;membrane;organelle lumen nucleotide binding;protein binding Pf00012 10525 ENSG00000280682.2; ENSG00000149428.18 HYOU1 11; CHR_HG2217_PATCH Scavenging by Class F Receptors; XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High Q96QK8 Small integral membrane protein 14 OS=Homo sapiens OX=9606 GN=SMIM14 PE=1 SV=1 0 13.917 51 3 12 3 99 10.7 5.29 3 2 6 6 18687215.13 23410019.25 4 4 Met-loss+Acetyl [N-Term] endoplasmic reticulum;membrane protein binding Pf11027 201895 ENSG00000163683.11 C4orf34; SMIM14 4 0 High P35613 Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2 0 20.948 20 6 12 6 385 42.2 5.66 1 6 3 1 7 4 162811.8862 1376825.125 11161481.27 4220919.25 3 4 6 4 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00047, Pf07679, Pf13895, Pf13927" 682 ENSG00000172270.18 BSG 19 Integrin cell surface interactions; Proton-coupled monocarboxylate transport; Basigin interactions; Degradation of the extracellular matrix; Pyruvate metabolism 0 High P10599 Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3 0 15.922 41 4 12 4 105 11.7 4.92 1 2 3 2 2 3 5 2 6286462.688 8950895.688 16213458 11553104.75 4 4 5 3 cell communication;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00085, Pf00462, Pf13098, Pf13899, Pf13905" 7295 ENSG00000136810.12 TXN 9 Interconversion of nucleotide di- and triphosphates; Protein repair; TP53 Regulates Metabolic Genes; The NLRP3 inflammasome; Oxidative Stress Induced Senescence; Detoxification of Reactive Oxygen Species NOD-like receptor signaling pathway 0 High Q9NP64 Nucleolar protein of 40 kDa OS=Homo sapiens OX=9606 GN=ZCCHC17 PE=1 SV=1 0 11.761 25 5 12 5 241 27.6 9.7 3 4 3 4 4 4 2720911.688 3880059.219 2822096.875 1317864.906 4 4 4 2 nucleus metal ion binding;protein binding;RNA binding Pf00575 51538 ENSG00000121766.15 ZCCHC17 1 0 Medium Q96Q89 Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3 0.041 1.155 0 1 12 1 1820 210.5 5.67 1 1 1 2 7 3 279702883.3 406741509.8 456210642.7 216707665.9 1 1 1 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf01576, Pf02463, Pf03961, Pf07851, Pf09726" 9585 ENSG00000138182.14 KIF20B 10 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins 0 High Q12888 TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2 0 17.231 8 7 12 7 1972 213.4 4.7 3 3 3 3 3 3 3 3 2745978.203 3630954.063 2352819.344 1948933.125 6 7 5 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding "Pf09038, Pf15057" 7158 ENSG00000067369.13 TP53BP1 15 G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ) NOD-like receptor signaling pathway 0 High Q92643 GPI-anchor transamidase OS=Homo sapiens OX=9606 GN=PIGK PE=1 SV=2 0 20.636 23 6 12 6 395 45.2 6.16 2 6 3 9 1921513.078 6063849.531 4 5 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf01650 10026 ENSG00000142892.14 PIGK 1 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High P0C0L4 Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2 0 15.116 4 5 12 5 1744 192.7 7.08 4 5 3 4 5 3 10865025.13 10555092.44 11331512.69 4 5 4 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 720; 721 ENSG00000244731.7 C4A; C4B 6 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5 Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Staphylococcus aureus infection 0 High Q9BSG0 Protease-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRADC1 PE=1 SV=1 0 14.318 32 6 12 6 188 21 5.47 5 6 5 7 15549531.5 30713583.56 5 6 extracellular protein binding Pf02225 84279 ENSG00000135617.3 PRADC1 2 0 High P35579 Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4 0 15.677 5 9 12 8 1960 226.4 5.6 2 7 1 2 2 7 1 2 730853.5166 3312869.922 1614079.855 9464499.715 4 7 6 4 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00063, Pf01442, Pf01496, Pf01576, Pf01765, Pf02736, Pf03962, Pf04111, Pf04156, Pf05911, Pf06637, Pf07888, Pf09731, Pf11068, Pf11559, Pf12128, Pf13094" 4627 ENSG00000100345.20 MYH9 22 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Salmonella infection; Regulation of actin cytoskeleton 1 High P62913 60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2 0 10.243 25 4 12 4 178 20.2 9.6 3 2 3 1 4 3 3 2 12573371.63 24758313.75 20011073.5 17146329.63 3 3 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00281, Pf00673" 6135 ENSG00000142676.12 RPL11 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P49756 RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3 0 11.328 8 5 12 5 843 100.1 6.32 5 3 2 2 5 3 2 2 3741569.063 3784501 4360643.531 3285654.313 5 4 5 5 metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf01480, Pf14259" 58517 ENSG00000119707.13 RBM25 14 Spliceosome 0 High Q92878 DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1 0 19.881 7 9 12 9 1312 153.8 6.89 9 1 1 10 1 1 6431388.984 13079996.78 7620052.578 10886942.4 6 9 8 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf02463, Pf04423, Pf13304, Pf13476, Pf13514, Pf13555, Pf13558" 10111 ENSG00000113522.13 RAD50 5 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Non-homologous end-joining 0 High P16615 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1 0 11.133 6 6 11 6 1042 114.7 5.34 4 4 3 4 4 3 817810.0625 4123259.844 4767760.031 2406179.266 2 6 6 5 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 488 ENSG00000174437.16 ATP2A2 12 Ion homeostasis; Pre-NOTCH Processing in Golgi; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; cGMP-PKG signaling pathway; Thyroid hormone signaling pathway; Adrenergic signaling in cardiomyocytes; Pancreatic secretion; Alzheimer's disease; Cardiac muscle contraction; cAMP signaling pathway; Calcium signaling pathway; Hypertrophic cardiomyopathy (HCM) 0 High P62899 60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1 0 8.273 31 4 11 4 125 14.5 10.54 1 3 2 3 1 3 3 4 6581137.563 12150523.63 9418741.313 8135067.375 4 4 4 4 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01198 6160 ENSG00000071082.10 RPL31 2 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P54136 "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" 0 15.994 10 6 11 6 660 75.3 6.68 4 2 3 2 4 2 3 2 2141827.531 2561459.969 2715121.625 1623106.75 4 4 5 3 metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00750, Pf03485, Pf05746" 5917 ENSG00000113643.8 RARS 5 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High P46783 40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1 0 11.243 15 3 11 3 165 18.9 10.15 2 3 2 3 2 3 3 3 615414.625 498508.1563 2135964.688 1231048.063 1 1 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf03501 6204 ENSG00000124614.13 RPS10 6 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q07666 "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" 0 16.52 13 5 11 5 443 48.2 8.66 3 5 2 4 5 2 3748517.563 1550579.594 4963339.406 2914423.125 5 3 5 5 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 10657 ENSG00000121774.17 KHDRBS1 1 PTK6 Regulates Proteins Involved in RNA Processing 0 High P14618 Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4 0 19.683 15 6 11 6 531 57.9 7.84 1 6 2 1 8 2 1659576.891 1471068.438 5175071.5 3064501.438 4 4 5 4 cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00224, Pf02887" 5315 ENSG00000067225.17 PKM 15 Glycolysis; Neutrophil degranulation Viral carcinogenesis; Central carbon metabolism in cancer; Carbon metabolism; Purine metabolism; Pyruvate metabolism; Type II diabetes mellitus; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High Q13472 DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1 0 19.325 11 8 11 8 1001 112.3 8.34 8 1 1 9 1 1 4861339.656 976862.9688 1174861.859 6 3 4 metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf01131, Pf01396, Pf01751, Pf06839" 7156 ENSG00000177302.14; ENSG00000284238.1 TOP3A 17; CHR_HSCHR17_3_CTG1 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 High Q14103 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1 0 12.976 15 5 11 3 355 38.4 7.81 1 1 4 4 1 1 5 4 1896119.125 3752535.125 4538822.5 2269069.281 3 3 3 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 3184 ENSG00000138668.18 HNRNPD 4 mRNA Splicing - Major Pathway 0 High Q13625 Apoptosis-stimulating of p53 protein 2 OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=2 0 13.527 5 4 11 4 1128 125.5 6.07 3 2 3 4 3 4 772090.5313 1112027 1275287.375 2 2 2 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;mitochondrion;nucleus protein binding "Pf00018, Pf00023, Pf04111, Pf04156, Pf06785, Pf07653, Pf12252, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604, Pf15548" 7159 TP53BP2 1 Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation of PUMA and translocation to mitochondria Hippo signaling pathway 0 High Q4VCS5 Angiomotin OS=Homo sapiens OX=9606 GN=AMOT PE=1 SV=1 0 19.843 13 8 11 8 1084 118 7.64 8 3 8 3 5431371.031 259357.2188 1404628.828 364874.7813 5 1 4 2 cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol protein binding;receptor activity Pf12240 154796 ENSG00000126016.15 AMOT X Signaling by Hippo Hippo signaling pathway 0 High P0DP25 Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1 0 15.018 22 2 11 2 149 16.8 4.22 2 1 2 2 2 4 3 2 3154474.875 7151694.938 5351863.906 2471043.344 2 3 3 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane catalytic activity;enzyme regulator activity;metal ion binding;protein binding;transporter activity "Pf00036, Pf08726, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658" 808; 805; 801 ENSG00000160014.16; ENSG00000143933.16; ENSG00000198668.10 CALM3; CALM2; CALM1 19; 2; 14 "Smooth Muscle Contraction; Uptake and function of anthrax toxins; Stimuli-sensing channels; Translocation of GLUT4 to the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Reduction of cytosolic Ca++ levels; CREB phosphorylation through the activation of CaMKII; Ion homeostasis; Ca2+ pathway; Phase 0 - rapid depolarisation; Calcineurin activates NFAT; Platelet degranulation ; eNOS activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; CaMK IV-mediated phosphorylation of CREB; Activation of CaMK IV; RAF/MAP kinase cascade; Inactivation, recovery and regulation of the phototransduction cascade; FCERI mediated Ca+2 mobilization; Cam-PDE 1 activation; Glycogen breakdown (glycogenolysis); Signaling by GPCR; Sodium/Calcium exchangers; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Interleukin-20 family signaling; RHO GTPases activate PAKs; Protein methylation; DARPP-32 events; RHO GTPases activate IQGAPs; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Ras activation uopn Ca2+ infux through NMDA receptor; PKA activation; Ion transport by P-type ATPases; Transcriptional activation of mitochondrial biogenesis; Activation of Ca-permeable Kainate Receptor; CLEC7A (Dectin-1) induces NFAT activation" Dopaminergic synapse; Phototransduction; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Renin secretion; Neurotrophin signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; Long-term potentiation; Glioma; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Pertussis; Melanogenesis; Alzheimer's disease; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; Alcoholism; Ras signaling pathway; GnRH signaling pathway; cAMP signaling pathway; Estrogen signaling pathway; Calcium signaling pathway 0 High O75400 Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2 0 5.063 2 3 11 3 957 108.7 7.56 2 3 1 2 3 4 1 3 2335797.438 3512985.063 4089151.313 3600757.625 3 3 3 3 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00397, Pf01846" 55660 PRPF40A 2 mRNA Splicing - Major Pathway Spliceosome 0 High P62877 E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1 0 15.729 26 3 11 3 108 12.3 6.96 3 3 2 4 5 2 12564617.17 8418621.563 3634433.813 4 4 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf13639" 9978 ENSG00000100387.8 RBX1 22 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of RAS by GAPs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Hedgehog 'on' state; Gap-filling DNA repair synthesis and ligation in TC-NER; Degradation of DVL; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Prolactin receptor signaling; Neddylation; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dual incision in TC-NER; Regulation of expression of SLITs and ROBOs TGF-beta signaling pathway; HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Protein processing in endoplasmic reticulum; Renal cell carcinoma; Nucleotide excision repair; Wnt signaling pathway; Oocyte meiosis; Circadian rhythm; Cell cycle 0 High Q02978 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens OX=9606 GN=SLC25A11 PE=1 SV=3 0 20.585 23 6 11 6 314 34 9.91 2 6 2 9 453767.2188 798665.875 4463153.344 9738792.469 1 1 4 6 Met-loss+Acetyl [N-Term] metabolic process;transport membrane;mitochondrion;nucleus RNA binding;transporter activity Pf00153 8402 ENSG00000108528.13 SLC25A11 17 Gluconeogenesis 0 High P26599 Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1 0 12.595 10 5 11 5 531 57.2 9.17 4 1 4 1 4 1 5 1 2802536.25 2935106.281 8510239.156 4645246 4 3 4 3 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 5725 ENSG00000011304.19 PTBP1 19 mRNA Splicing - Major Pathway; FGFR2 alternative splicing 0 High Q15717 ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2 0 18.508 27 6 11 6 326 36.1 9.17 3 2 4 1 3 2 4 2 3913614.563 4918805.125 5768476.281 3299325.5 4 4 4 3 development;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 1994 ENSG00000066044.14 ELAVL1 19 HuR (ELAVL1) binds and stabilizes mRNA; mRNA Splicing - Major Pathway AMPK signaling pathway 0 High Q8NC56 LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1 0 12.359 10 4 11 4 503 56.9 9 4 2 2 6 2 3 6737558.5 1431918.406 2551295.063 4 3 3 cell differentiation;cell organization and biogenesis;regulation of biological process chromosome;endoplasmic reticulum;membrane;nucleus DNA binding;protein binding "Pf03020, Pf09402" 221496 ENSG00000161904.11 LEMD2 6 Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High P35232 Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1 0 14.364 24 6 11 6 272 29.8 5.76 2 5 3 2 5 4 2419473.125 1915032.438 4919237.25 3628460.438 6 5 6 5 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus DNA binding;protein binding Pf01145 5245 ENSG00000167085.11 PHB 17 Paradoxical activation of RAF signaling by kinase inactive BRAF; Processing of SMDT1; RAF activation; Signaling by RAS mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling 0 High Q9BTY2 Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2 0 18.041 18 8 10 8 467 54 6.25 8 10 862179.6563 12300040.88 4 7 metabolic process;regulation of biological process;response to stimulus;transport extracellular;organelle lumen catalytic activity;protein binding Pf01120 2519 ENSG00000001036.13 FUCA2 6 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation Other glycan degradation 0 High O14818 Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1 0 8.725 23 4 10 4 248 27.9 8.46 4 1 2 5 2 3 74933.14844 4349416.281 2718067.969 2913615.469 1 3 3 3 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;nucleotide binding;protein binding "Pf00227, Pf10584" 5688 ENSG00000101182.14 PSMA7 20 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2 0 13.622 3 6 10 6 2136 244.4 6.06 4 2 2 2 4 2 2 2 1922022.969 3333522.969 2572468.219 2478969.531 3 5 4 4 cell differentiation;cell organization and biogenesis;metabolic process membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02889, Pf04851" 23020 ENSG00000144028.14 SNRNP200 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9H307 Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5 0 13.164 7 4 10 4 717 81.6 7.14 1 2 3 1 1 3 5 1 4035435.625 5962630.125 5809594.25 3987701.75 2 2 2 2 0 High Q9P0U4 CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2 0 10.047 9 4 10 4 656 75.7 8.24 3 3 2 5 3 2 2578332.875 2251799.813 2078426.438 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00628, Pf02008, Pf12269" 30827 ENSG00000154832.14 CXXC1 18 XBP1(S) activates chaperone genes 0 High Q08170 Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2 0 6.416 9 4 10 1 494 56.6 11.52 2 3 2 1 2 5 2 1 metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6429 ENSG00000116350.16 SRSF4 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 0 High Q9P2E5 Chondroitin sulfate glucuronyltransferase OS=Homo sapiens OX=9606 GN=CHPF2 PE=2 SV=2 0 16.811 15 9 10 9 772 85.9 7.83 9 10 1123430 687921.9531 1293701.781 5190961.703 2 2 2 6 metabolic process Golgi;membrane catalytic activity "Pf02434, Pf05679" 54480 ENSG00000033100.16 CHPF2 7 Chondroitin sulfate biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High P05386 60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1 0 18.858 75 3 10 3 114 11.5 4.32 1 2 1 3 1 2 1 6 1086213.102 2008798.508 3509405.016 2888217.875 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;ribosome enzyme regulator activity;protein binding;structural molecule activity Pf00428 6176 ENSG00000137818.11 RPLP1 15 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8N1N4 "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" 0 5.316 4 2 10 1 520 56.8 6.02 2 2 2 2 2 2 3 3 472260.375 424608.8438 513577.0938 393669.9688 1 1 1 1 cell death cytosol structural molecule activity "Pf00038, Pf12128, Pf13166" 196374 ENSG00000170423.12 KRT78 12 Formation of the cornified envelope 0 High Q9UK97 F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1 0 20.743 21 8 10 8 447 52.3 6.15 6 4 6 4 2048157.813 7777652.219 5096283.625 5 8 6 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;protein binding "Pf00646, Pf12937" 26268 ENSG00000112146.16 FBXO9 6 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q14134 Tripartite motif-containing protein 29 OS=Homo sapiens OX=9606 GN=TRIM29 PE=1 SV=2 0 17.424 15 9 10 9 588 65.8 7.15 9 10 10379135 9829078 21249693.19 16937046 1 1 8 1 metabolic process;regulation of biological process cytoplasm metal ion binding;protein binding "Pf00643, Pf03938" 23650 ENSG00000137699.16 TRIM29 11 Interferon gamma signaling 0 High O96019 Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1 0 12.743 17 5 10 5 429 47.4 5.6 2 2 2 4 2 2 2 4 5927686 8936640 8764373.375 8387239.688 3 4 4 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding Pf00022 86 ENSG00000136518.16 ACTL6A 3 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; UCH proteinases; DNA Damage Recognition in GG-NER; RMTs methylate histone arginines; HATs acetylate histones 0 High P49368 T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4 0 15.39 15 7 10 7 545 60.5 6.49 2 1 4 3 2 1 4 3 2354494.438 2923111.188 3589205.844 4597000.188 6 5 5 6 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane nucleotide binding;protein binding;RNA binding Pf00118 7203 ENSG00000163468.14 CCT3 1 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High Q6MZM0 Ferroxidase HEPHL1 OS=Homo sapiens OX=9606 GN=HEPHL1 PE=1 SV=2 0 23.553 10 8 9 8 1159 131.5 6.74 8 9 6437306.219 7 metabolic process;transport membrane catalytic activity;metal ion binding "Pf07731, Pf07732" 341208 ENSG00000181333.11 HEPHL1 11 0 High P50897 Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1 0 15.53 21 4 9 4 306 34.2 6.52 1 4 1 8 860078.3125 4954718.313 1 3 cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen;vacuole catalytic activity;protein binding Pf02089 5538 ENSG00000131238.16 PPT1 1 Fatty acyl-CoA biosynthesis Lysosome; Fatty acid elongation; Metabolic pathways; Fatty acid metabolism 0 High Q16880 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Homo sapiens OX=9606 GN=UGT8 PE=2 SV=2 0 22.381 18 8 9 8 541 61.4 9.52 8 9 342738.1406 6166442.32 2 6 cell organization and biogenesis;metabolic process membrane catalytic activity "Pf00201, Pf04101" 7368 ENSG00000174607.10 UGT8 4 Glycosphingolipid metabolism Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways 0 High Q9NVF7 F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1 0 18.311 15 4 9 4 368 41.1 9.55 1 4 2 1 4 4 3384998.031 2612014.188 2808497.813 3 2 2 chromosome protein binding Pf00646 23219 ENSG00000143756.11 FBXO28 1 0 High Q92530 Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2 0 14.154 12 2 9 2 271 29.8 5.74 2 2 2 2 2 5 4001122.219 2551275.414 2937815.594 2 2 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;proteasome enzyme regulator activity;protein binding "Pf08577, Pf11566" 9491 ENSG00000125818.17 PSMF1 20 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q9ULM3 YEATS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=YEATS2 PE=1 SV=2 0 16.465 8 8 9 8 1422 150.7 8.98 6 3 6 3 1067068.688 3300988.531 2650088.625 2571434 2 6 5 3 cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding Pf03366 55689 ENSG00000163872.15 YEATS2 3 HATs acetylate histones 0 High Q69YQ0 Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=2 0 25.525 9 7 9 7 1117 124.5 5.72 2 6 2 7 2102544.906 3217348.375 487828.9219 4 4 2 cell division;metabolic process cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf00038, Pf00307, Pf01920, Pf02463, Pf03251, Pf04111, Pf04156, Pf05667, Pf05701, Pf08317, Pf11971, Pf12128, Pf13166" 23384 SPECC1L 22 0 High Q08188 Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens OX=9606 GN=TGM3 PE=1 SV=4 0 18.736 13 8 9 8 693 76.6 5.86 8 9 83738.10938 12020544.13 525104.0313 1 8 2 cell differentiation;cell organization and biogenesis;metabolic process cytoplasm catalytic activity;metal ion binding "Pf00868, Pf00927, Pf01841" 7053 ENSG00000125780.11 TGM3 20 0 High P35268 60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2 0 9.312 35 3 9 3 128 14.8 9.19 2 3 1 3 4 2 7406528.25 9997648.5 11424845.75 9071219.75 2 2 3 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01776 6146 ENSG00000116251.9 RPL22 1 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P60891 Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2 0 9.831 12 3 9 2 318 34.8 6.98 2 1 1 3 2 2 2 3 835935.5313 2235187.969 2390761.25 2128096.063 2 2 2 2 metabolic process cytosol catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00156, Pf13793, Pf14572" 5631 ENSG00000147224.10 PRPS1 X 5-Phosphoribose 1-diphosphate biosynthesis Carbon metabolism; Purine metabolism; Pentose phosphate pathway; Biosynthesis of amino acids; Metabolic pathways 1 High P54132 Bloom syndrome protein OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1 0 11.938 6 6 9 6 1417 158.9 7.49 5 1 2 5 1 3 6341098.188 694757.125 1757111.969 6 2 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382" 641 ENSG00000197299.10 BLM 15 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Fanconi anemia pathway 0 High Q8TF66 Leucine-rich repeat-containing protein 15 OS=Homo sapiens OX=9606 GN=LRRC15 PE=2 SV=2 0 20.399 13 8 9 8 581 64.3 6.71 8 9 997532.0625 10872534.5 2 8 regulation of biological process;response to stimulus cytoplasm;membrane enzyme regulator activity;protein binding "Pf12799, Pf13306, Pf13855" 131578 ENSG00000172061.8 LRRC15 3 0 Medium Q96C24 Synaptotagmin-like protein 4 OS=Homo sapiens OX=9606 GN=SYTL4 PE=1 SV=2 0.035 1.219 1 1 9 1 671 76 8.98 1 1 1 1 2 3 2 2 681188469.5 399546946.8 502592503.1 241335462.5 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;membrane metal ion binding;protein binding "Pf00168, Pf02318, Pf02891" 94121 ENSG00000102362.15 SYTL4 X Platelet degranulation 0 High Q93074 Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4 0 16.199 4 4 9 4 2177 242.9 7.05 2 3 3 2 3 4 3081891.875 9156816.5 6776546.75 2893985.125 4 4 3 3 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;protein binding;receptor activity "Pf09497, Pf12144, Pf12145" 9968 ENSG00000184634.15 MED12 X Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q93063 Exostosin-2 OS=Homo sapiens OX=9606 GN=EXT2 PE=1 SV=1 0 14.15 10 6 9 6 718 82.2 6.55 6 9 55208.91797 6928996.688 1 5 cell differentiation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf03016, Pf09258" 2132 ENSG00000151348.13 EXT2 11 HS-GAG biosynthesis; Defective EXT2 causes exostoses 2 Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways 0 High Q8N0V3 "Putative ribosome-binding factor A, mitochondrial OS=Homo sapiens OX=9606 GN=RBFA PE=1 SV=3" 0 17.603 20 4 9 4 343 38.3 7.85 2 2 3 3 2 4 1753386.047 1351068.156 1428788.383 1487651.234 5 2 4 3 metabolic process mitochondrion catalytic activity;protein binding "Pf02033, Pf02637" 79863 ENSG00000101546.12 RBFA 18 0 High O14617 AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1 0 12.487 6 5 9 5 1153 130.1 8.48 1 5 2 1 5 3 1349372.063 880348.0938 1983380.172 1395827.578 5 3 5 3 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;Golgi;membrane transporter activity "Pf01602, Pf06375" 8943 ENSG00000065000.15 AP3D1 19 Lysosome 0 High Q9BYR7 Keratin-associated protein 3-2 OS=Homo sapiens OX=9606 GN=KRTAP3-2 PE=1 SV=1 0 12.206 24 2 9 1 98 10.4 5.69 2 9 63411371.75 1 Acetyl [N-Term] cytosol protein binding;structural molecule activity Pf04579 83897 ENSG00000263296.2; ENSG00000212900.2 KRTAP3-2 17; CHR_HSCHR17_4_CTG4 Keratinization 0 High Q9BYR6 Keratin-associated protein 3-3 OS=Homo sapiens OX=9606 GN=KRTAP3-3 PE=1 SV=1 0 15.018 28 3 9 2 98 10.4 5.69 3 9 112401675.5 4 Acetyl [N-Term] cytosol protein binding;structural molecule activity Pf04579 85293 ENSG00000212899.2; ENSG00000263101.2 KRTAP3-3 17; CHR_HSCHR17_4_CTG4 Keratinization 2 High P62847 40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1 0 9.278 18 3 9 3 133 15.4 10.78 2 1 1 1 3 3 2 1 2499234.875 3543688.031 3877587.563 490334.5156 3 3 3 2 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01282 6229 ENSG00000138326.18 RPS24 10 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P12532 "Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1A PE=1 SV=1" 0 12.061 14 4 9 4 417 47 8.34 1 2 4 2 1 2 4 2 977585.0625 2110544.25 2292008.156 291781.25 1 1 2 1 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding "Pf00217, Pf02807" 1159; 548596 ENSG00000223572.9; ENSG00000237289.9 CKMT1B; CKMT1A 15 Creatine metabolism Metabolic pathways; Arginine and proline metabolism 0 High Q08378 Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2 0 23.411 8 8 9 8 1498 167.3 5.44 8 9 6786277.828 390611.7266 566171.2656 312641.375 8 2 2 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf01576, Pf02463, Pf04111, Pf05557, Pf07888, Pf10186, Pf12128, Pf12325" 2802 ENSG00000090615.14 GOLGA3 12 0 High Q14978 Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2 0 6.701 6 4 9 4 699 73.6 9.47 2 2 2 2 3 2 2 2 4450335.238 5523621 6867452.691 3526377.641 4 3 4 3 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus nucleotide binding;protein binding;RNA binding Pf05022 9221 ENSG00000166197.16 NOLC1 10 0 High P10515 "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" 0 8.409 5 4 9 4 647 69 7.84 4 1 1 7 1 1 8278235.25 685831.8125 1073772.25 861940.6719 4 1 1 2 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 1737 ENSG00000150768.15 DLAT 11 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High O95147 Dual specificity protein phosphatase 14 OS=Homo sapiens OX=9606 GN=DUSP14 PE=1 SV=1 0 27.163 36 5 9 5 198 22.2 9.57 5 9 82602.74219 12916762.75 1 7 metabolic process;regulation of biological process catalytic activity;protein binding;RNA binding "Pf00102, Pf00782" 11072 ENSG00000275932.2; ENSG00000276023.4 DUSP14 17; CHR_HSCHR17_7_CTG4 0 High P33764 Protein S100-A3 OS=Homo sapiens OX=9606 GN=S100A3 PE=1 SV=1 0 18.202 53 5 8 5 101 11.7 4.78 5 8 78058.77344 220703.6563 20435284.94 1 1 5 Met-loss+Acetyl [N-Term] cytoplasm;cytosol metal ion binding Pf01023 6274 ENSG00000188015.9 S100A3 1 0 High Q8IUD2 ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1 0 10.731 4 5 8 2 1116 128 5.97 3 4 3 5 1588740.141 4071986.094 192906.7656 4 5 1 development;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;Golgi;membrane protein binding;transporter activity "Pf01496, Pf04156, Pf05529, Pf05557, Pf05622, Pf07888, Pf09457, Pf09726, Pf10174, Pf10186, Pf12128, Pf13166" 23085 ENSG00000283017.1; ENSG00000082805.19 ERC1 12; CHR_HSCHR12_2_CTG1 NF-kappa B signaling pathway 3 High Q15046 Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3 0 8.792 8 4 8 4 597 68 6.35 3 2 2 1 3 2 2 1 2921220.219 3485282.75 2119026.469 2281693.266 4 4 3 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf00587, Pf01336" 3735 ENSG00000065427.14 KARS 16 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis 0 High P62854 40S ribosomal protein S26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3 0 7.876 31 3 8 3 115 13 11 1 2 3 1 1 2 3 2 4332846.625 9600068 9455188.375 6809961.375 2 2 3 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01283 6231; 101929876; 728937 ENSG00000197728.9 RPS26; LOC101929876; RPS26P25 12; 20; 4 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High O00264 Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3 0 5.425 13 3 8 2 195 21.7 4.7 1 2 2 1 3 4 227888.4531 1096360.938 2666613.188 2431147 1 3 3 3 transport endoplasmic reticulum;membrane protein binding Pf00173 10857 ENSG00000101856.9 PGRMC1 X Neutrophil degranulation 1 High P62081 40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1 0 9.233 21 3 8 3 194 22.1 10.1 1 1 2 3 1 1 3 3 1673261.281 2235298.656 3565626.063 4400741 2 2 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01251 6201 ENSG00000171863.12 RPS7 2 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q96HA1 Nuclear envelope pore membrane protein POM 121 OS=Homo sapiens OX=9606 GN=POM121 PE=1 SV=2 0 10.973 6 5 8 5 1249 127.6 10.56 5 1 1 6 1 1 270057.8594 2879433.25 534385.3125 384914.8125 2 3 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;nucleus protein binding;structural molecule activity;transporter activity Pf15229 9883 ENSG00000196313.11 POM121 7 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q15392 Delta(24)-sterol reductase OS=Homo sapiens OX=9606 GN=DHCR24 PE=1 SV=2 0 7.952 6 3 8 3 516 60.1 8.16 2 2 3 2 3 3 1388352.969 2045476.75 3403125.813 3 3 3 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding Pf01565 1718 ENSG00000116133.11 DHCR24 1 Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol Steroid biosynthesis; Metabolic pathways 0 High P46782 40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4 0 16.475 27 5 8 5 204 22.9 9.72 1 5 1 1 5 2 850362 5003314.938 5390210.25 3136773.188 2 4 4 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00177 6193 ENSG00000083845.8 RPS5 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q8TBK6 Zinc finger CCHC domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZCCHC10 PE=1 SV=1 0 4.944 7 1 8 1 192 21 8.53 1 1 1 1 2 2 2 2 2064862.25 1802062.875 2193794 1852497 1 1 1 1 metal ion binding;protein binding Pf13917 54819 ENSG00000155329.11 ZCCHC10 5 0 High P60412 Keratin-associated protein 10-11 OS=Homo sapiens OX=9606 GN=KRTAP10-11 PE=1 SV=3 0 20.618 24 4 8 4 298 30.2 7.49 4 8 10178883.63 4 cytosol protein binding 386678 ENSG00000243489.4 KRTAP10-11 21 Keratinization 0 High Q8WYQ9 Zinc finger CCHC domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZCCHC14 PE=1 SV=1 0 14.429 11 7 8 7 949 100 8.18 7 8 3062593.625 819315.0625 547844.5 888969.9531 4 1 1 2 metal ion binding;protein binding "Pf00098, Pf00536" 23174 ENSG00000140948.11 ZCCHC14 16 0 High P14678 Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2 0 4.779 6 2 8 2 240 24.6 11.19 1 1 2 1 1 2 3 2 1644887.813 1548336.188 2976193.219 1625528.938 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6628 ENSG00000125835.18 SNRPB 20 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome; Systemic lupus erythematosus 0 High Q9HCE1 Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2 0 14.04 6 6 8 6 1003 113.6 8.82 1 5 1 1 1 5 1 1 1054637.953 3522260.094 1665836.344 1347042.031 4 6 5 5 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding;RNA binding "Pf13086, Pf13087, Pf13245, Pf13401, Pf13604" 4343 ENSG00000155363.18 MOV10 1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence 0 High Q13247 Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2 0 10.315 14 6 8 3 344 39.6 11.43 1 4 2 1 1 4 2 1 3519846.938 7998416.125 3885397.531 2603655.563 4 5 4 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 6431 ENSG00000124193.14 SRSF6 20 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 2 High Q9NVC6 Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2 0 12.131 9 5 8 5 651 72.8 7.44 1 2 5 1 2 5 1490516.625 1441478.031 2341298.094 2607102.719 5 4 5 5 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity Pf10156 9440 ENSG00000042429.11 MED17 11 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q9Y251 Heparanase OS=Homo sapiens OX=9606 GN=HPSE PE=1 SV=2 0 17.923 10 4 8 4 543 61.1 9.28 4 8 639020.0625 6550304.063 449661.5313 1 4 1 metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;nucleus;organelle lumen;vacuole catalytic activity;protein binding Pf03662 10855 ENSG00000173083.14 HPSE 4 HS-GAG degradation; Neutrophil degranulation Glycosaminoglycan degradation; Proteoglycans in cancer; Metabolic pathways 0 High P84090 Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1 0 13.414 34 3 8 3 104 12.3 5.92 2 2 3 1 2 2 3 1 4067869.313 4845174.688 5153429.188 2708359.5 3 3 3 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process DNA binding;nucleotide binding;protein binding;RNA binding Pf01133 2079 ENSG00000100632.10 ERH 14 0 High P11586 "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3" 0 10.592 7 5 8 5 935 101.5 7.3 2 3 2 1 2 3 2 1 4182954.172 5338337.438 3421645.438 3939837.594 4 5 3 4 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00763, Pf01268, Pf02882" 4522 MTHFD1 14 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 High P12004 Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1 0 15.724 27 5 8 5 261 28.8 4.69 1 1 2 4 1 1 2 4 1073468.156 3425635.844 4185876.25 5126374.469 3 5 4 5 cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding "Pf00705, Pf02747" 5111 ENSG00000132646.10 PCNA 20 Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Activation of E2F1 target genes at G1/S; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Transcription of E2F targets under negative control by DREAM complex; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; SUMOylation of DNA replication proteins; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; E3 ubiquitin ligases ubiquitinate target proteins; Dual incision in TC-NER; Removal of the Flap Intermediate from the C-strand Hepatitis B; DNA replication; Mismatch repair; Base excision repair; HTLV-I infection; Nucleotide excision repair; Cell cycle 0 High Q9UK99 F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3 0 13.621 10 4 8 4 471 54.5 5 2 3 3 2 3 3 47069.64063 3463552.188 3242850.813 2128309.688 1 3 3 2 metabolic process;regulation of biological process cytosol;nucleus catalytic activity;protein binding "Pf00646, Pf04379, Pf06881, Pf09346, Pf12937" 26273 ENSG00000110429.13 FBXO3 11 0 High P25786 Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1 0 9.808 23 5 8 5 263 29.5 6.61 5 2 1 5 2 1 1304610.75 5711171.5 3367334.5 4137434.984 1 5 4 5 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding;RNA binding "Pf00227, Pf10584" 5682 ENSG00000129084.17 PSMA1 11 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High Q8WVK2 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP27 PE=1 SV=1 0 9.696 17 3 8 3 155 18.8 11.62 2 2 2 1 2 3 2 1 2396655.594 2229621.75 1727020.563 803061.75 3 3 2 2 metabolic process nucleus protein binding Pf08648 11017 ENSG00000124380.10 SNRNP27 2 mRNA Splicing - Major Pathway Spliceosome 0 High P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4 0 15.293 19 6 8 6 456 50.8 6.55 1 6 1 7 358587.875 865969.2813 2332189.813 8064888.656 1 2 2 4 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;protein binding Pf03345 1650 ENSG00000244038.9 DDOST 1 Advanced glycosylation endproduct receptor signaling; Asparagine N-linked glycosylation; Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q13148 TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1 0 10.439 16 3 7 3 414 44.7 6.19 1 1 2 2 2 1 2 2 489238.0938 515429.3438 552340 1148650.094 1 1 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 23435 ENSG00000120948.16 TARDBP 1 0 High Q9UBF6 RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1 0 9.749 28 2 7 2 113 12.7 5.44 1 2 1 1 1 4 1 1 1723847.609 3231388 959690.4375 430471.1875 2 2 2 1 Met-loss+Acetyl [N-Term] metabolic process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf12678, Pf12861, Pf13639" 9616 ENSG00000114125.13 RNF7 3 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation Ubiquitin mediated proteolysis 0 High Q9NXV2 BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1 0 10.953 20 3 7 3 234 26.1 6.24 2 2 3 2 2 3 3045117.125 2300380.875 3199782.328 2 2 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus protein binding Pf02214 54442 ENSG00000167977.8 KCTD5 16 0 High Q8TD19 Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2 0 14.538 7 6 7 6 979 107.1 5.74 6 7 4409500.875 147132.3438 127756.2188 6 1 1 cell division;cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00415, Pf07714, Pf13540, Pf14531" 91754 ENSG00000119638.12 NEK9 14 "Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly" 0 High P62316 Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1 0 10.061 32 3 7 3 118 13.5 9.91 1 2 3 1 1 2 3 1 2258915.25 1695230.313 3330539.375 884688.6875 2 2 2 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6633 ENSG00000125743.10 SNRPD2 19 snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9Y6G9 Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3 0 7.443 8 3 7 3 523 56.5 6.42 3 1 1 1 4 1 1 1 1416104.688 1011113.063 1173856.313 1102117.406 2 2 2 2 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00005, Pf05783" 51143 ENSG00000144635.8 DYNC1LI1 3 COPI-independent Golgi-to-ER retrograde traffic; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High P82650 "28S ribosomal protein S22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" 0 8.669 10 3 7 3 360 41.3 7.9 2 2 1 2 2 2 1 2 850373.3438 1885001.375 1633112.656 1045153.859 2 3 3 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf10245 56945 ENSG00000175110.11 MRPS22 3 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High P24666 Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3 0 3.353 6 1 7 1 158 18 6.74 1 1 1 1 1 2 2 2 646403.75 1219432.625 1940657.25 2421265 1 1 1 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding Pf01451 52 ENSG00000143727.15 ACP1 2 Thiamine metabolism; Adherens junction; Metabolic pathways 0 High Q8IW35 Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1 0 11.014 7 6 7 6 865 96.9 5.02 2 3 2 2 3 2 338353.4609 2548795.125 3032866.75 1741038.391 2 3 4 3 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding "Pf12799, Pf13855, Pf14580" 79598 ENSG00000182504.10 CEP97 3 Anchoring of the basal body to the plasma membrane 0 High Q8TCJ2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens OX=9606 GN=STT3B PE=1 SV=1 0 6.794 5 5 7 4 826 93.6 8.91 5 7 197322.9063 2294766.625 1 3 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding "Pf02516, Pf13231" 201595 ENSG00000163527.9 STT3B 3 N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High P35222 Catenin beta-1 OS=Homo sapiens OX=9606 GN=CTNNB1 PE=1 SV=1 0 20.724 6 4 7 2 781 85.4 5.86 4 7 1509353.844 315116.7188 2 1 cell communication;cell differentiation;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;protein binding;signal transducer activity Pf00514 1499 ENSG00000168036.16 CTNNB1 3 "Beta-catenin phosphorylation cascade; CDO in myogenesis; Binding of TCF/LEF:CTNNB1 to target gene promoters; Apoptotic cleavage of cell adhesion proteins; RUNX3 regulates WNT signaling; S37 mutants of beta-catenin aren't phosphorylated; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Ca2+ pathway; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Misspliced GSK3beta mutants stabilize beta-catenin; Adherens junctions interactions; Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability" Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Hippo signaling pathway; Rap1 signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; HTLV-I infection; Melanogenesis; Wnt signaling pathway; Focal adhesion; Proteoglycans in cancer; Adherens junction; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Thyroid cancer; Basal cell carcinoma; Signaling pathways regulating pluripotency of stem cells 0 High P62273 40S ribosomal protein S29 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2 0 5.133 46 3 7 3 56 6.7 10.13 2 2 2 1 2 2 2 1 3659277.313 4860402.375 4904072.563 2140087.844 3 3 3 3 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome metal ion binding;structural molecule activity Pf00253 6235 ENSG00000213741.9 RPS29 14 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P22234 Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3 0 8.158 9 3 7 3 425 47 7.23 2 1 2 2 2 1 2 2 1630740.219 1501965.219 1944531.438 1254053.938 3 3 3 3 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00731, Pf01259" 10606 ENSG00000128050.8 PAICS 4 Purine ribonucleoside monophosphate biosynthesis Purine metabolism; Metabolic pathways 0 High P62857 40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1 0 10.07 46 3 7 3 69 7.8 10.7 2 2 2 1 2 2 2 1 2216475.875 6291652.438 4974956.625 2643294.938 2 3 2 2 cell organization and biogenesis;metabolic process;transport cytosol;ribosome protein binding;RNA binding;structural molecule activity Pf01200 6234 ENSG00000233927.4 RPS28 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P29692 Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5 0 9.712 12 3 7 3 281 31.1 5.01 2 2 3 2 2 3 2529973.875 2327338 2927626.063 2065164.156 3 3 3 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus DNA binding;protein binding;RNA binding;signal transducer activity "Pf00736, Pf10587" 1936 ENSG00000104529.17; ENSG00000273594.4 EEF1D 8; CHR_HSCHR8_3_CTG7 Eukaryotic Translation Elongation Herpes simplex infection 0 High P00738 Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 0 9.931 9 3 7 3 406 45.2 6.58 2 2 2 2 3 2 4485131.563 4796957.375 2984221.625 3 3 3 defense response;metabolic process;regulation of biological process;response to stimulus;transport extracellular;organelle lumen antioxidant activity;catalytic activity;protein binding Pf00089 3240 ENSG00000257017.8 HP 16 Neutrophil degranulation; Scavenging of heme from plasma 0 High P07477 Trypsin-1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1 0 4.475 4 1 7 1 247 26.5 6.51 1 1 1 1 1 3 2 1 1065680.375 4251649.313 2019703.281 556686.4375 2 2 2 1 cell organization and biogenesis;metabolic process extracellular catalytic activity;metal ion binding Pf00089 5644 ENSG00000274247.4; ENSG00000204983.13 PRSS1 7; CHR_HSCHR7_2_CTG6 "Activation of Matrix Metalloproteinases; Cobalamin (Cbl, vitamin B12) transport and metabolism" Neuroactive ligand-receptor interaction; Protein digestion and absorption; Pancreatic secretion; Influenza A 0 Medium Q03001 Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4 0.011 1.57 0 1 7 1 7570 860.1 5.25 1 1 1 1 2 2 1 2 38636542.69 27687262.13 40027190.31 32670965.56 1 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus metal ion binding;protein binding "Pf00307, Pf00435, Pf00681, Pf02187, Pf11971, Pf13499, Pf13833" 667 DST 6 Type I hemidesmosome assembly 0 High O15460 Prolyl 4-hydroxylase subunit alpha-2 OS=Homo sapiens OX=9606 GN=P4HA2 PE=1 SV=1 0 9.106 10 5 7 5 535 60.9 5.71 2 1 4 2 1 4 862872.0781 2515036.719 2136963.281 3245760.375 3 4 4 4 metabolic process cytosol;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336, Pf13640" 8974 ENSG00000072682.18 P4HA2 5 Collagen biosynthesis and modifying enzymes Metabolic pathways; Arginine and proline metabolism 0 High Q9C005 Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1 0 10.674 47 4 7 4 99 11.2 4.88 1 2 2 2 1 2 2 2 450060.6563 2256216.586 1948731.719 3324102.625 1 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;transport Golgi;nucleus catalytic activity;protein binding Pf05186 84661 ENSG00000162961.13 DPY30 2 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 0 High Q9NZ01 Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1 0 10.142 12 3 7 3 308 36 9.45 1 3 3 1 3 3 253174.7969 940237.7188 3453941.281 4231989 1 2 3 3 metabolic process cytoplasm;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding Pf02544 9524 ENSG00000099797.13 TECR 19 Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 High P62841 40S ribosomal protein S15 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2 0 10.479 21 2 7 2 145 17 10.39 1 2 1 2 4 1 300322.2266 1076373.938 1067073.219 1 2 2 cell differentiation;cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity Pf00203 6209 ENSG00000115268.9 RPS15 19 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High Q96N67 Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4 0 10.6 5 7 7 7 2140 242.4 6.8 7 7 3310613.313 1453244.5 1247594 4 1 1 cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus protein binding "Pf06920, Pf11878, Pf14429" 85440 ENSG00000116641.17 DOCK7 1 MET activates RAP1 and RAC1; Factors involved in megakaryocyte development and platelet production 0 High O75477 Erlin-1 OS=Homo sapiens OX=9606 GN=ERLIN1 PE=1 SV=2 0 8.261 9 3 7 3 348 39.1 7.87 1 1 3 2 1 1 3 2 1379626.75 1740466.5 3551259 3792250.75 3 3 3 3 0 High P63167 "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" 0 13.12 52 4 7 4 89 10.4 7.4 4 1 1 4 1 2 2903711.563 2348287.875 3536102 902216.6563 2 2 2 2 cell communication;cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding Pf01221 8655 ENSG00000088986.10 DYNLL1 12 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Activation of BIM and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; MHC class II antigen presentation; Macroautophagy Vasopressin-regulated water reabsorption 0 High P63241 Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2 0 11.917 31 4 7 4 154 16.8 5.24 1 1 4 1 1 1 4 1 1209051.359 1306854.438 3137901.688 1784150.594 3 2 4 3 cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus protein binding;RNA binding Pf01287 1984 ENSG00000132507.17 EIF5A 17 Hypusine synthesis from eIF5A-lysine 0 High Q86X55 Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3 0 8.808 9 5 7 5 608 65.8 6.73 1 2 2 2 1 2 2 2 934971.6563 1634077.344 3122978.438 2766963.063 3 3 4 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf02475, Pf05175, Pf05185, Pf06325, Pf08003, Pf08241, Pf08242, Pf11531, Pf12847, Pf13649, Pf13659, Pf13847" 10498 ENSG00000142453.11 CARM1 19 "Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression; PPARA activates gene expression; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription" Endocrine resistance 0 High Q8N9Q2 Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1 0 7.789 21 3 7 3 155 18.2 9.85 2 2 2 3 2 2 6795669.75 7477017.375 3471354.25 4670069 3 3 2 3 metabolic process metal ion binding;protein binding Pf13917 285672 ENSG00000153006.15 SREK1IP1 5 0 High Q5T749 Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1 0 14.129 13 5 7 5 579 64.1 8.27 3 1 1 2 3 1 1 2 5514090.938 6758068.547 7042897 3743253.375 4 4 3 4 cytoplasm protein binding 448834 ENSG00000203786.6 KPRP 1 0 High P09012 U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3 0 8.082 14 3 7 3 282 31.3 9.83 1 1 3 1 1 1 4 1 2120453.188 2002636.031 5361790.75 1994402.813 3 3 3 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6626 ENSG00000077312.8 SNRPA 19 mRNA Splicing - Major Pathway Spliceosome 0 High Q9Y265 RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1 0 2.961 2 1 7 1 456 50.2 6.42 1 1 1 1 2 1 2 2 1371063.25 1058898.5 1408026.875 1540559.5 1 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07726, Pf13191, Pf13238, Pf13245, Pf13481" 8607 ENSG00000175792.11 RUVBL1 3 Ub-specific processing proteases; UCH proteinases; DNA Damage Recognition in GG-NER; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; Deposition of new CENPA-containing nucleosomes at the centromere Wnt signaling pathway 0 High O75531 Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1 0 16.603 37 3 7 3 89 10.1 6.09 3 1 2 3 1 3 1728887.938 6982479.75 2103412.25 1372522.344 3 3 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;nucleus DNA binding;protein binding Pf02961 8815 ENSG00000175334.7 BANF1 11 2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin 0 High P49336 Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1 0 3.914 5 2 7 2 464 53.3 8.57 2 2 2 2 2 3 558421.9219 324430.5 679335.4688 845262.9688 2 1 2 2 metabolic process;regulation of biological process nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1024 ENSG00000132964.11 CDK8 13 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression 0 High P49916 DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2 0 8.538 6 4 6 4 1009 112.8 9.01 4 1 5 1 228914.3594 2545102.813 701754.125 1754329.156 1 4 2 3 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00645, Pf01068, Pf04675, Pf04679" 3980 ENSG00000005156.11 LIG3 17 Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER Base excision repair 0 High Q92542 Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2 0 10.524 6 4 6 4 709 78.4 5.99 1 4 1 5 106602.6016 1541325.063 2640834.688 1 2 3 cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;Golgi;membrane catalytic activity;protein binding Pf05450 23385 ENSG00000162736.15 NCSTN 1 Activated NOTCH1 Transmits Signal to the Nucleus; Signaling by NOTCH4; Regulated proteolysis of p75NTR; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NRIF signals cell death from the nucleus; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of the extracellular matrix; Neutrophil degranulation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Nuclear signaling by ERBB4; Signalling by NGF Alzheimer's disease; Notch signaling pathway 0 High Q14974 Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2 0 6.074 3 3 6 3 876 97.1 4.78 2 1 2 1 2 1 2 1 717219.625 1878135.328 1347133.344 1152915.031 3 3 3 3 Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen metal ion binding;protein binding;RNA binding;transporter activity "Pf02985, Pf03810, Pf13513, Pf13646" 3837 ENSG00000108424.9 KPNB1 17 ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Neutrophil degranulation; Regulation of cholesterol biosynthesis by SREBP (SREBF); Transport of Ribonucleoproteins into the Host Nucleus; Activation of DNA fragmentation factor RNA transport 0 Medium Q7Z5H4 Vomeronasal type-1 receptor 5 OS=Homo sapiens OX=9606 GN=VN1R5 PE=2 SV=2 0.032 1.247 2 1 6 1 357 40.8 9.2 1 1 1 2 2 2 261056.4063 2045972 2738939 2289689.75 1 1 1 1 regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity Pf03402 317705 VN1R5 1 0 High O75165 DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5 0 10.502 3 5 6 5 2243 254.3 6.74 5 1 5 1 1457354.859 433579.4219 4 2 cell differentiation;cell organization and biogenesis;regulation of biological process;transport cytosol;endosome;membrane protein binding "Pf00226, Pf14237" 23317 ENSG00000138246.15 DNAJC13 3 Neutrophil degranulation 0 High P52907 F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3 0 5.178 16 3 6 3 286 32.9 5.69 3 2 1 3 2 1 943832.4063 980960.1875 435371.2188 490586.7813 2 2 1 1 cell organization and biogenesis;cellular component movement;coagulation;defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular protein binding Pf01267 829 ENSG00000116489.12 CAPZA1 1 COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Advanced glycosylation endproduct receptor signaling; Factors involved in megakaryocyte development and platelet production; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Interleukin-12 family signaling Endocytosis 0 High Q9BU76 Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1 0 7.235 14 3 6 3 263 29.4 10.02 2 2 1 2 2 2 2881542.578 4136457.25 2708969.688 2655795.563 2 2 2 2 transport extracellular;organelle lumen protein binding;RNA binding Pf10159 79169 ENSG00000143793.12 C1orf35 1 Neutrophil degranulation 0 High P78347 General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2 0 8.829 6 5 6 5 998 112.3 6.39 5 1 5 1 8649166.375 423667.4531 804591.5 634977.2188 4 2 2 2 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus DNA binding;protein binding Pf02946 2969 ENSG00000263001.5 GTF2I 7 Basal transcription factors; cGMP-PKG signaling pathway; Herpes simplex infection 0 High Q3LI72 Keratin-associated protein 19-5 OS=Homo sapiens OX=9606 GN=KRTAP19-5 PE=1 SV=1 0 15.845 54 3 6 3 72 7.6 8.13 3 6 20518923.25 3 cytosol protein binding 337972 ENSG00000186977.2 KRTAP19-5 21 Keratinization 0 High Q9H936 Mitochondrial glutamate carrier 1 OS=Homo sapiens OX=9606 GN=SLC25A22 PE=1 SV=1 0 13.871 21 4 6 4 323 34.4 9.29 1 4 1 5 718409.875 2541683.125 2 2 transport membrane;mitochondrion transporter activity Pf00153 79751 ENSG00000177542.10 SLC25A22 11 Organic anion transporters 0 High Q15291 Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2 0 5.059 7 3 6 3 538 59.1 5.1 2 2 1 3 2 1 32068.46289 2259441.719 1882855.516 754142.1563 1 3 3 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding Pf00400 5929 ENSG00000117222.13 RBBP5 1 Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex; Neddylation 0 High P36957 "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" 0 7.802 7 3 6 3 453 48.7 8.95 3 1 5 1 4236320.75 354439.6875 683431.1875 365693.2813 3 1 1 1 metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity "Pf00198, Pf00364" 1743 ENSG00000119689.14 DLST 14 Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Lysine degradation; Metabolic pathways 0 High Q08380 Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1 0 12.634 6 3 6 3 585 65.3 5.27 2 2 4 2 1157940.859 3560211.906 1743972.625 616041.3125 4 4 3 1 defense response;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen protein binding;receptor activity "Pf00530, Pf07707" 3959 ENSG00000108679.12 LGALS3BP 17 Platelet degranulation 0 High P01599 Immunoglobulin kappa variable 1-17 OS=Homo sapiens OX=9606 GN=IGKV1-17 PE=1 SV=2 0.007 1.721 13 1 6 1 117 12.8 8.68 1 1 1 2 2 2 1034150 17120382 17667488 9631990 1 1 1 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane catalytic activity "Pf00047, Pf07679, Pf07686, Pf13927" 28937 ENSG00000281978.1; ENSG00000240382.3 IGKV1-17 2; CHR_HG2290_PATCH FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis 0 High O75607 Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3 0 9.957 18 2 6 2 178 19.3 4.63 2 2 2 2 2 2 419837.5156 834181.3125 1432381.031 1986113.563 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process cytoskeleton;cytosol;nucleus protein binding;RNA binding "Pf02087, Pf03066" 10360 ENSG00000107833.10 NPM3 10 0 High Q15393 Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4 0 3.858 2 2 6 2 1217 135.5 5.26 1 1 2 1 1 1 3 1 184413.3906 674447.0938 858627.6563 581467.1406 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf03178, Pf10433" 23450 ENSG00000189091.12 SF3B3 16 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P08559 "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" 0 5.487 6 2 6 2 390 43.3 8.06 1 1 2 1 1 1 3 1 672786.4375 920208.1563 1413924.438 928191 2 2 2 2 metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00676 5160 ENSG00000131828.13 PDHA1 X Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High Q14247 Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2 0 11.948 10 5 6 5 550 61.5 5.4 1 2 3 1 2 3 1763306.906 1544373.625 1858152.875 1310080.313 4 3 3 3 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane protein binding "Pf00018, Pf02218, Pf07653, Pf14604" 2017 ENSG00000085733.15 CTTN 11 RHO GTPases activate PAKs; Clathrin-mediated endocytosis Tight junction; Pathogenic Escherichia coli infection; Proteoglycans in cancer; Bacterial invasion of epithelial cells; Shigellosis 0 High Q9NUD5 Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2 0 10.054 15 3 6 3 403 43.5 8.53 2 2 1 3 2 1 200111.0156 2052485.125 752518.8281 347051.5859 2 3 2 2 0 High O95218 Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2 0.001 2.205 3 1 6 1 330 37.4 10.01 1 1 1 1 1 1 2 2 1451904.125 1559547.875 2509929.25 1998213.5 1 1 1 1 metabolic process;regulation of biological process nucleus metal ion binding;protein binding;RNA binding Pf00641 9406 ENSG00000132485.13 ZRANB2 1 0 High Q16891 MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1 0 7.771 5 4 6 4 758 83.6 6.48 3 2 1 3 2 1 659316.4063 735980.4688 1755927.563 1605658.031 2 2 3 3 cell organization and biogenesis;cellular homeostasis membrane;mitochondrion protein binding;RNA binding Pf09731 10989 ENSG00000132305.20 IMMT 2 Cristae formation 0 High Q9BZX2 Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1 0 7.756 12 3 6 3 261 29.3 6.7 1 1 2 2 1 1 2 2 887644.3438 1240342.672 1498561.813 2425961.906 3 3 3 3 metabolic process cytosol catalytic activity;nucleotide binding "Pf00485, Pf13207" 7371 ENSG00000143179.14 UCK2 1 Pyrimidine salvage Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High P08236 Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2 0 3.412 2 2 6 2 651 74.7 7.02 1 1 2 1 2 3 48613.08594 214304.7656 3019985.313 5132774.25 1 1 2 2 metabolic process;transport extracellular;membrane;organelle lumen;vacuole catalytic activity;protein binding "Pf02836, Pf02837, Pf12876" 2990 ENSG00000169919.16 GUSB 7 MPS VII - Sly syndrome; Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation Lysosome; Glycosaminoglycan degradation; Porphyrin and chlorophyll metabolism; Pentose and glucuronate interconversions; Metabolic pathways; Drug metabolism - other enzymes 0 High P62318 Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1 0 13.688 32 3 6 3 126 13.9 10.32 1 1 1 2 1 1 1 3 3347596.938 2485674.125 4780702.625 4040530.5 3 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6634 ENSG00000100028.11 SNRPD3 22 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome; Systemic lupus erythematosus 0 High P78371 T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4 0 10.183 11 4 6 4 535 57.5 6.46 1 3 2 1 3 2 242957.5313 342769.9063 703607.1563 1 1 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;organelle lumen nucleotide binding;protein binding Pf00118 10576 ENSG00000166226.12 CCT2 12 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC 0 High Q9UBL3 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1 0 9.157 8 4 6 4 628 68.7 5.69 2 3 1 2 3 1 114494.8125 2848829.438 2632596.219 628603.3359 1 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf00622 9070 ENSG00000129691.15 ASH2L 8 Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex 0 High P62314 Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1 0 6.86 28 2 6 2 119 13.3 11.56 1 2 1 1 4 1 2370759.563 1409381.125 3782544.563 1867076.531 1 1 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 6632 ENSG00000167088.10 SNRPD1 18 snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Systemic lupus erythematosus 0 High P63244 Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3 0 8.779 19 4 6 4 317 35.1 7.69 1 2 3 1 2 3 456075.8047 1631011.531 2453107.75 1990674.719 3 3 3 3 Met-loss+Acetyl [N-Term] cell death;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome enzyme regulator activity;protein binding;RNA binding;structural molecule activity Pf00400 10399 ENSG00000204628.11 GNB2L1; RACK1 5 Regulation of TNFR1 signaling; TNFR1-mediated ceramide production; TNFR1-induced NFkappaB signaling pathway Measles 0 High P83881 60S ribosomal protein L36a OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2 0 3.524 16 2 6 2 106 12.4 10.58 1 2 2 1 1 2 2 1 2982525.688 4983434.625 4560352.375 3390717.5 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00935 6173 ENSG00000241343.9 RPL36A X Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P37198 Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3 0 12.392 7 3 6 3 522 53.2 5.31 1 2 2 1 2 3 1357820.344 1677474.938 10358857.95 2 2 3 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity;transporter activity Pf05064 23636 ENSG00000213024.11 NUP62 19 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P02747 Complement C1q subcomponent subunit C OS=Homo sapiens OX=9606 GN=C1QC PE=1 SV=3 0 4.245 7 1 6 1 245 25.8 8.41 1 1 1 2 2 2 2444642.5 2368519.75 2885005 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane catalytic activity;protein binding "Pf00229, Pf00386" 714 ENSG00000159189.11 C1QC 1 Regulation of Complement cascade; Classical antibody-mediated complement activation Chagas disease (American trypanosomiasis); Prion diseases; Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Staphylococcus aureus infection 0 High Q96GM5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2 0 4.667 5 3 6 2 515 58.2 9.25 1 2 1 2 1 2 1 2 666622.7344 1176713.313 710829.4375 485470.75 2 2 2 1 cell organization and biogenesis;regulation of biological process;response to stimulus nucleus protein binding;structural molecule activity "Pf02084, Pf02201" 6602 ENSG00000066117.14 SMARCD1 12 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q9P035 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2 0 12.703 15 5 6 5 362 43.1 8.94 1 1 4 1 1 4 888265.0313 4118442.563 3506936.25 3 5 4 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding "Pf04387, Pf04969" 51495 ENSG00000074696.12 PTPLAD1; HACD3 15 Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism 0 High Q9UJS0 Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens OX=9606 GN=SLC25A13 PE=1 SV=2 0 9.072 11 4 6 3 675 74.1 8.62 1 1 4 1 1 4 296766.25 843057.875 1719077.031 2437784 1 2 3 4 metabolic process;response to stimulus;transport membrane;mitochondrion metal ion binding;transporter activity "Pf00153, Pf13499" 10165 ENSG00000004864.13 SLC25A13 7 Gluconeogenesis; Mitochondrial protein import; Metabolism of proteins 1 High P06493 Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3 0 5.138 11 3 6 2 297 34.1 8.4 1 2 2 1 2 3 2380524.172 2490099.906 2542616.313 1907369.625 2 2 2 2 cell death;cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;receptor activity "Pf00069, Pf01636, Pf07714, Pf14531" 983 ENSG00000170312.15 CDK1 10 "Regulation of PLK1 Activity at G2/M Transition; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Recruitment of NuMA to mitotic centrosomes; Ovarian tumor domain proteases; Loss of Nlp from mitotic centrosomes; Activation of E2F1 target genes at G1/S; MASTL Facilitates Mitotic Progression; Golgi Cisternae Pericentriolar Stack Reorganization; Activation of NIMA Kinases NEK9, NEK6, NEK7; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by RUNX2; Interleukin-20 family signaling; APC/C:Cdc20 mediated degradation of Cyclin B; G2/M DNA replication checkpoint; Condensation of Prometaphase Chromosomes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of TP53 Degradation; Phosphorylation of Emi1; MAPK3 (ERK1) activation; Recruitment of mitotic centrosome proteins and complexes; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; E2F-enabled inhibition of pre-replication complex formation; Phosphorylation of the APC/C; Depolymerisation of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Resolution of Sister Chromatid Cohesion; Condensation of Prophase Chromosomes; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling" Viral carcinogenesis; Epstein-Barr virus infection; Progesterone-mediated oocyte maturation; Gap junction; p53 signaling pathway; Oocyte meiosis; Herpes simplex infection; Cell cycle 0 High Q15843 NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1 0 6.485 17 1 6 1 81 9.1 8.43 1 1 1 1 2 3 273691.5 3838447 3967153.75 2561764.75 1 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding "Pf00240, Pf11976" 4738 ENSG00000129559.12 NEDD8 14 Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; TGF-beta receptor signaling activates SMADs; Iron uptake and transport; Neddylation 0 High Q14498 RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2 0 8.104 6 3 6 3 530 59.3 10.1 3 1 2 3 1 2 2294627.188 2718115.273 1965668.477 967049.6875 3 3 3 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoskeleton;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259, Pf15519" 9584 ENSG00000131051.22 RBM39 20 0 Low P56545 C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1 0.051 1.015 2 1 6 1 445 48.9 6.95 1 1 4 2 23281064.25 33518776.31 1 1 cell differentiation;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00389, Pf02826" 1488 ENSG00000175029.16 CTBP2 10 Repression of WNT target genes; TCF7L2 mutants don't bind CTBP Chronic myeloid leukemia; Pathways in cancer; Wnt signaling pathway; Notch signaling pathway 0 High Q99623 Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2 0 7.667 14 4 6 4 299 33.3 9.83 1 2 3 1 2 3 668262.1875 137998.0781 1087100.781 1164794.25 2 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;membrane;mitochondrion;nucleus protein binding Pf01145 11331 ENSG00000215021.8 PHB2 12 Processing of SMDT1 0 High Q96S52 GPI transamidase component PIG-S OS=Homo sapiens OX=9606 GN=PIGS PE=1 SV=3 0 10.557 8 3 6 3 555 61.6 6.49 3 3 3 3 1694104.297 861852.125 3 3 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf10510 94005 ENSG00000087111.20 PIGS 17 Attachment of GPI anchor to uPAR Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 High P57088 Transmembrane protein 33 OS=Homo sapiens OX=9606 GN=TMEM33 PE=1 SV=2 0 3.871 8 2 6 2 247 28 9.7 1 2 2 4 137308.0313 334095.625 1050806.625 2038175.75 1 1 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;nucleus protein binding;structural molecule activity Pf03661 55161 ENSG00000109133.12 TMEM33 4 0 High Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3 0 9.534 3 4 6 4 1555 177.1 5.63 3 2 4 2 650380.8281 1680459.688 1456583.672 2 3 3 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen catalytic activity;protein binding Pf06427 56886 ENSG00000136731.12 UGGT1 2 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens OX=9606 GN=CAMK2A PE=1 SV=2 0 6.22 5 2 6 2 478 54.1 7.08 1 1 2 1 2 1 2 1 1048840.938 655139.2188 1311922 319342.0625 2 2 2 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf08332, Pf13474, Pf14534" 815 ENSG00000070808.15 CAMK2A 5 "Ion homeostasis; HSF1-dependent transactivation; Interferon gamma signaling; Ca2+ pathway; Phase 0 - rapid depolarisation; Ras activation uopn Ca2+ infux through NMDA receptor; Ion transport by P-type ATPases; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of AMPA receptors; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling" Dopaminergic synapse; HIF-1 signaling pathway; Amphetamine addiction; Neurotrophin signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; ErbB signaling pathway; Long-term potentiation; Insulin secretion; Glioma; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Melanogenesis; Wnt signaling pathway; Proteoglycans in cancer; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Axon guidance; cAMP signaling pathway; Cholinergic synapse; Calcium signaling pathway 0 High P22087 rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2 0 7.278 14 3 6 3 321 33.8 10.18 1 2 2 1 1 2 2 1 712890.2188 1144465.438 1399723.75 1165363 2 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process chromosome;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf01135, Pf01269, Pf13847" 2091 ENSG00000280548.3; ENSG00000105202.8 FBL 19; CHR_HG2021_PATCH Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9BSD7 Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1 0 9.843 29 4 6 4 190 20.7 9.54 1 1 4 1 1 4 272932.9141 871654.5313 1139295.25 2691726.25 2 2 2 2 metabolic process;response to stimulus membrane catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01583, Pf03029, Pf03266, Pf05496, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13238" 84284 ENSG00000135778.11 NTPCR 1 Purine metabolism; Thiamine metabolism; Metabolic pathways 0 High Q05519 Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1 0 7.678 7 2 6 2 484 53.5 10.52 1 1 1 2 2 1 1 2 1141441.875 626932.125 1195144.125 1201963.75 1 1 1 1 metabolic process;transport nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 9295 ENSG00000116754.13 SRSF11 1 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway 0 High P84243 Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3A PE=1 SV=2 0 4.866 18 3 6 2 136 15.3 11.27 1 2 1 2 2 2 2264911.75 9430238 29487629 5053058.813 1 2 2 2 cell differentiation;cell organization and biogenesis;cell proliferation;coagulation;metabolic process;regulation of biological process;response to stimulus chromosome;extracellular;nucleus DNA binding;protein binding "Pf00125, Pf15630" 3020; 440926; 3021 ENSG00000132475.10; ENSG00000163041.9 H3F3A; H3F3AP4; H3F3B 1; 2; 17 SIRT1 negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening Transcriptional misregulation in cancer; Systemic lupus erythematosus; Alcoholism 1 High Q9H3K2 Growth hormone-inducible transmembrane protein OS=Homo sapiens OX=9606 GN=GHITM PE=1 SV=2 0 7.353 9 3 6 3 345 37.2 9.94 3 2 4 2 7122356.625 3752400.063 3 3 cell death membrane;mitochondrion protein binding 27069 ENSG00000165678.20 GHITM 10 0 High Q13263 Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5 0 7.48 8 3 6 3 835 88.5 5.77 1 1 2 2 1 1 2 2 418368.5313 566045.0625 1419725.219 432769.6563 1 1 2 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00628, Pf00643" 10155 ENSG00000130726.11 TRIM28 19 Generic Transcription Pathway 0 High Q96KG9 N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1 0 11.292 8 4 6 4 808 89.6 6.3 4 1 1 4 1 1 5567222.375 1479011.688 1372536.031 4 3 2 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00069, Pf07714" 57410 ENSG00000142186.16 SCYL1 11 0 High Q16630 Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2 0 10.627 7 3 5 3 551 59.2 7.15 2 1 2 2 1 2 1623157.75 1152935.75 1712656.031 703368.6875 2 2 3 2 cell organization and biogenesis;metabolic process membrane;nucleus protein binding;RNA binding "Pf00076, Pf14259" 11052 ENSG00000111605.16 CPSF6 12 Signaling by cytosolic FGFR1 fusion mutants mRNA surveillance pathway 0 High P21796 Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2 0 10.77 16 4 5 4 283 30.8 8.54 4 5 119954.4453 4780694.188 1058343.313 1 4 3 cell communication;cell death;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf01459 7416 ENSG00000213585.10 VDAC1 5 Mitochondrial calcium ion transport; Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway 0 High Q08945 FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1 0 7.598 5 3 5 3 709 81 6.87 3 2 3 2 174774.3438 1505542.188 1342119.656 769529.8281 1 3 3 2 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf03531, Pf08512, Pf09011" 6749 ENSG00000149136.8 SSRP1 11 HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat 0 High P04279 Semenogelin-1 OS=Homo sapiens OX=9606 GN=SEMG1 PE=1 SV=2 0 14.254 15 4 5 3 462 52.1 9.29 4 5 3836742.75 4 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus extracellular;nucleus metal ion binding;protein binding Pf05474 6406 ENSG00000124233.11 SEMG1 20 Antimicrobial peptides; Amyloid fiber formation 1 High Q13155 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2 0 6.668 8 1 5 1 320 35.3 8.22 1 1 1 2 2 1 1292908.875 1242643.25 1152646.75 603298 1 1 1 1 cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;structural molecule activity "Pf13410, Pf14497" 7965 ENSG00000106305.9 AIMP2 7 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins 0 High P53396 ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3 0 3.829 2 2 5 2 1101 120.8 7.33 2 1 1 1 2 1 1 1 669093.5 190473.0781 922693.0313 504364.0156 2 1 2 2 metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00285, Pf00549, Pf02629, Pf08442" 47 ENSG00000131473.16 ACLY 17 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Neutrophil degranulation Citrate cycle (TCA cycle); Metabolic pathways 0 High Q3LI83 Keratin-associated protein 24-1 OS=Homo sapiens OX=9606 GN=KRTAP24-1 PE=2 SV=1 0 7.417 18 4 5 4 254 27.7 8.29 4 5 10660884.13 4 cytosol structural molecule activity Pf05287 643803 ENSG00000188694.5 KRTAP24-1 21 Keratinization 0 High O15083 ERC protein 2 OS=Homo sapiens OX=9606 GN=ERC2 PE=1 SV=3 0 7.998 4 4 5 1 957 110.5 6.99 2 3 2 3 transport cytoplasm;cytoskeleton protein binding;transporter activity "Pf01496, Pf04156, Pf10174, Pf13166" 26059 ENSG00000187672.12 ERC2 3 0 High Q9BVK6 Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TMED9 PE=1 SV=2 0 6.297 9 3 5 3 235 27.3 8.02 2 2 3 2 277758.1406 488808.8438 6531689.75 4005067.813 2 1 3 3 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf01105 54732 ENSG00000184840.11 TMED9 5 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 High P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4 0 12.329 10 4 5 4 589 65.3 5.11 2 1 2 2 1 2 759321.6563 1703574.938 1993338.5 2257856.5 2 2 2 2 Met-loss+Acetyl [N-Term] cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;protein binding "Pf02985, Pf13513, Pf13646" 5518 ENSG00000105568.17 PPP2R1A 19 "Glycolysis; Regulation of PLK1 Activity at G2/M Transition; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; AURKA Activation by TPX2; S33 mutants of beta-catenin aren't phosphorylated; Anchoring of the basal body to the plasma membrane; S45 mutants of beta-catenin aren't phosphorylated; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of mitotic centrosome proteins and complexes; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; Initiation of Nuclear Envelope Reformation; Loss of Nlp from mitotic centrosomes; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex" Dopaminergic synapse; Chagas disease (American trypanosomiasis); TGF-beta signaling pathway; Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; Long-term depression; mRNA surveillance pathway; Oocyte meiosis; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway 0 High P38919 Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4 0 7.825 5 2 5 2 411 46.8 6.73 2 2 1 2 2 1 1522267.594 1264262.141 6252192.844 1768542.938 2 2 2 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 9775 ENSG00000141543.9 EIF4A3 17 ISG15 antiviral mechanism; mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA Spliceosome; mRNA surveillance pathway; RNA transport 0 High O95613 Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4 0 9.17 2 5 5 5 3336 377.8 5.55 5 5 669503.2188 142447 86682.35938 2 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding;structural molecule activity "Pf01576, Pf09726, Pf09731, Pf10495" 5116 ENSG00000160299.16 PCNT 21 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High Q13501 Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1 0 7.629 13 2 5 2 440 47.7 5.22 2 1 2 2 1 2 1942055.5 368412.0313 394995.1875 566995.1875 2 1 1 1 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00564, Pf00569" 8878 ENSG00000161011.19 SQSTM1 5 Interleukin-1 family signaling; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes; NRIF signals cell death from the nucleus; Pink/Parkin Mediated Mitophagy Osteoclast differentiation 0 High Q8WVX9 Fatty acyl-CoA reductase 1 OS=Homo sapiens OX=9606 GN=FAR1 PE=1 SV=1 0 14.851 11 5 5 5 515 59.3 9.17 5 5 213858.5 204868.7969 1654669.031 4521714.375 2 1 5 5 metabolic process membrane;organelle lumen catalytic activity "Pf01370, Pf03015, Pf07993" 84188 ENSG00000197601.12 FAR1 11 Wax biosynthesis Peroxisome 0 High Q07627 Keratin-associated protein 1-1 OS=Homo sapiens OX=9606 GN=KRTAP1-1 PE=1 SV=1 0 14.474 27 2 5 2 177 18.2 5.76 2 5 9888526.875 2 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 81851 ENSG00000188581.8; ENSG00000262808.2 KRTAP1-1 17; CHR_HSCHR17_4_CTG4 Keratinization 0 High Q6NXT1 Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2 0 8.496 21 5 5 5 300 32.5 6.28 5 5 10539146 14640870.25 11767798 12580302 1 3 1 1 regulation of biological process;transport cytoplasm;nucleus enzyme regulator activity;protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 129138 ENSG00000100124.14 ANKRD54 22 0 High P81605 Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2 0 5.136 13 2 5 2 110 11.3 6.54 1 2 1 1 2 2 1259896.625 245003.2031 1547989.625 767456.6875 2 1 2 1 defense response;metabolic process;response to stimulus extracellular catalytic activity;protein binding;RNA binding Pf15291 117159 ENSG00000161634.11 DCD 12 Antimicrobial peptides 0 High O75718 Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1 0 13.652 15 5 5 5 401 46.5 5.73 5 5 207586.0781 3735131 1 3 metabolic process;regulation of biological process endoplasmic reticulum;extracellular;organelle lumen protein binding 10491 ENSG00000170275.14 CRTAP 3 Collagen biosynthesis and modifying enzymes 0 High Q9Y277 Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1 0 14.822 24 5 5 5 283 30.6 8.66 5 5 5294952.125 140321.5313 5 1 Met-loss+Acetyl [N-Term] cell communication;defense response;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus nucleotide binding;transporter activity Pf01459 7419 ENSG00000078668.13 VDAC3 8 Mitochondrial calcium ion transport; Ub-specific processing proteases Viral carcinogenesis; NOD-like receptor signaling pathway; Hepatitis B; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway 0 High P62861 40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1 0 4.232 19 2 5 2 59 6.6 12.15 2 1 1 1 2 1 1 1 2931112.125 5317400.5 5206244 3148688.688 2 2 2 2 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;ribosome RNA binding;structural molecule activity Pf04758 2197 FAU 11 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" 0 High P47929 Galectin-7 OS=Homo sapiens OX=9606 GN=LGALS7 PE=1 SV=2 0 8.022 26 3 5 3 136 15.1 7.62 3 5 288565.4219 13985823.25 156237.7031 2 3 1 cell death cytoplasm;extracellular;nucleus Pf00337 3963; 653499 ENSG00000282902.1; ENSG00000283082.1; ENSG00000205076.4; ENSG00000178934.4 LGALS7; LGALS7B 19; CHR_HG26_PATCH 0 High Q9NYF8 Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2 0 8.156 5 3 5 3 920 106.1 9.98 2 1 2 2 1 2 1436256.313 1443724.188 1252722.281 350026.9063 2 2 2 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding Pf15440 9774 ENSG00000029363.16 BCLAF1 6 0 High Q6P2Q9 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2 0 8.54 2 4 5 4 2335 273.4 8.84 1 1 2 1 1 1 2 1 1428852.531 3067318.938 2809797.266 2475127.906 4 4 4 3 cell organization and biogenesis;metabolic process;response to stimulus membrane;nucleus;spliceosomal complex catalytic activity;protein binding;RNA binding "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" 10594 ENSG00000174231.16; ENSG00000274442.2 PRPF8 17; CHR_HSCHR17_1_CTG2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q96TA2 ATP-dependent zinc metalloprotease YME1L1 OS=Homo sapiens OX=9606 GN=YME1L1 PE=1 SV=2 0 9.393 5 3 5 3 773 86.4 8.76 1 3 1 4 72542.86719 1101680.063 1347102.906 1 2 2 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf01434" 10730 ENSG00000136758.18 YME1L1 10 Processing of SMDT1 0 High Q02413 Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2 0 9.74 5 4 5 4 1049 113.7 5.03 2 1 2 2 1 2 972974.7813 1404487.844 1027668.719 884902.875 3 3 2 2 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoskeleton;cytosol;membrane metal ion binding;protein binding "Pf00028, Pf01049" 1828 ENSG00000134760.5 DSG1 18 Apoptotic cleavage of cell adhesion proteins; Formation of the cornified envelope; Neutrophil degranulation Staphylococcus aureus infection 0 High Q8TED9 Actin filament-associated protein 1-like 1 OS=Homo sapiens OX=9606 GN=AFAP1L1 PE=1 SV=2 0 6.54 8 4 5 4 768 86.4 6.8 2 1 2 2 1 2 1613679.656 964091.4375 1066754.031 3 2 2 cytoplasm protein binding Pf00169 134265 ENSG00000157510.13 AFAP1L1 5 0 High O95292 Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3 0.001 2.368 6 1 5 1 243 27.2 7.3 1 1 1 1 2 1 1 1 481957.5625 776708.625 668548 794194.625 1 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;Golgi;membrane protein binding "Pf00635, Pf00843" 9217 ENSG00000124164.15 VAPB 20 Sphingolipid de novo biosynthesis 0 High Q9Y446 Plakophilin-3 OS=Homo sapiens OX=9606 GN=PKP3 PE=1 SV=1 0 7.309 5 4 5 4 797 87 9.32 4 5 3495860.438 4 cell death;cell organization and biogenesis;regulation of biological process cytoskeleton;membrane;nucleus protein binding;RNA binding;translation regulator activity Pf00514 11187 ENSG00000184363.9 PKP3 11 Formation of the cornified envelope 0 High Q9BYQ9 Keratin-associated protein 4-8 OS=Homo sapiens OX=9606 GN=KRTAP4-8 PE=2 SV=4 0 17.59 19 1 5 1 185 19.6 7.75 1 5 13356670.13 2 Met-loss [N-Term] cytosol 728224 ENSG00000204880.7 KRTAP4-8 17 Keratinization 0 High P20618 Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2 0 6.836 14 3 5 3 241 26.5 8.13 2 1 2 2 1 2 437370.5156 3133764.063 1586231.406 1154423.906 2 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome catalytic activity;protein binding Pf00227 5689 ENSG00000008018.8 PSMB1 6 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High P61964 WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1 0 9.859 16 3 5 3 334 36.6 8.27 2 3 2 3 824836.75 5840386 4779768.625 1944867.281 1 3 2 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;protein binding "Pf00400, Pf08662, Pf11715" 11091 ENSG00000196363.9 WDR5 9 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation 0 High Q92900 Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2 0 8.473 4 4 5 4 1129 124.3 6.61 2 1 2 2 1 2 1033569.719 555080.3438 1373600.547 611562.25 4 3 4 3 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf04851, Pf09416, Pf13086, Pf13087, Pf13245, Pf13604" 5976 ENSG00000005007.12 UPF1 19 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High P28072 Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4 0 5.827 13 3 5 3 239 25.3 4.92 3 1 1 3 1 1 99414.88281 2914411.281 1208165.031 1453307.438 1 3 2 3 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding Pf00227 5694 ENSG00000142507.9 PSMB6 17 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High P11802 Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2 0 3.254 8 2 5 1 303 33.7 7.01 2 2 2 3 182812.9688 488599.4375 426182.1563 538972 1 1 1 1 cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 1019 ENSG00000135446.16 CDK4 12 Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Ubiquitin-dependent degradation of Cyclin D1; Cyclin D associated events in G1; SCF(Skp2)-mediated degradation of p27/p21; Meiotic recombination; PTK6 Regulates Cell Cycle; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Transcriptional regulation by RUNX2; Oxidative Stress Induced Senescence Viral carcinogenesis; T cell receptor signaling pathway; Tight junction; Hepatitis B; Pancreatic cancer; Chronic myeloid leukemia; Non-small cell lung cancer; Breast cancer; Pathways in cancer; Glioma; AGE-RAGE signaling pathway in diabetic complications; Melanoma; HTLV-I infection; p53 signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Cell cycle; Endocrine resistance; PI3K-Akt signaling pathway 0 High P08621 U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2 0 7.911 10 4 5 4 437 51.5 9.94 3 2 3 2 2516329.656 941917.1406 3301094.313 668247.7188 3 2 3 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf12220, Pf13893, Pf14259" 6625 ENSG00000104852.14 SNRNP70 19 mRNA Splicing - Major Pathway Spliceosome 0 High Q99538 Legumain OS=Homo sapiens OX=9606 GN=LGMN PE=1 SV=1 0 18.603 12 4 5 4 433 49.4 6.55 4 5 5793973.438 793410.2344 4 2 metabolic process;regulation of biological process;response to stimulus endosome;organelle lumen;vacuole catalytic activity Pf01650 5641 ENSG00000100600.14 LGMN 14 Vitamin D (calciferol) metabolism; MHC class II antigen presentation; Trafficking and processing of endosomal TLR Lysosome; Antigen processing and presentation 0 High O75717 WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 0 8.041 6 5 5 5 1129 125.9 5.62 5 5 1695601.766 165350.6875 4 1 cytoplasm;nucleus DNA binding;protein binding "Pf00400, Pf00505, Pf08662" 11169 ENSG00000198554.11 WDHD1 14 0 High Q6STE5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 OS=Homo sapiens OX=9606 GN=SMARCD3 PE=1 SV=1 0 3.807 5 3 5 1 483 55 9.35 1 2 2 1 2 2 296766.25 685342.625 889376.4375 959262.125 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding Pf02201 6604 ENSG00000082014.16 SMARCD3 7 "Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; PPARA activates gene expression; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription" 0 High Q5T4B2 Inactive glycosyltransferase 25 family member 3 OS=Homo sapiens OX=9606 GN=CERCAM PE=1 SV=1 0 11.576 9 4 5 4 595 67.5 6.06 4 5 2634594.344 4 cellular component movement endoplasmic reticulum;membrane;organelle lumen Pf01755 51148 ENSG00000167123.18 CERCAM 9 0 High Q86SG7 Lysozyme g-like protein 2 OS=Homo sapiens OX=9606 GN=LYG2 PE=1 SV=2 0 13.83 31 5 5 5 212 23.5 8.87 5 5 2884986 4 defense response;metabolic process;response to stimulus extracellular catalytic activity Pf01464 254773 ENSG00000185674.9 LYG2 2 0 High Q92522 Histone H1.10 OS=Homo sapiens OX=9606 GN=H1-10 PE=1 SV=1 0 7.339 11 3 5 3 213 22.5 10.76 2 1 2 2 1 2 1565061.953 2944995.469 2683272.469 1729247.563 3 3 3 2 cell organization and biogenesis chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 8971 ENSG00000184897.5 H1FX 3 0 High Q99615 DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2 0 11.967 9 4 5 4 494 56.4 6.96 3 2 3 2 206755.0469 487082.1563 3096204.938 1996947.125 1 2 4 3 metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;protein binding "Pf00226, Pf00515, Pf07719, Pf13414, Pf13424, Pf13431, Pf13432" 7266 ENSG00000168259.14 DNAJC7 17 Regulation of HSF1-mediated heat shock response 0 High Q7L4I2 Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1 0 9.047 8 3 5 3 434 50.5 11.33 2 1 1 1 2 1 1 1 2802664.063 2134406.938 2586635.438 1353476.266 3 3 3 3 protein binding;RNA binding Pf15477 65117 ENSG00000111011.17 RSRC2 12 0 High Q9Y5M8 Signal recognition particle receptor subunit beta OS=Homo sapiens OX=9606 GN=SRPRB PE=1 SV=3 0 15.846 18 3 5 3 271 29.7 9.04 2 3 2 3 1508476.313 2632105.625 2 2 regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane nucleotide binding "Pf00009, Pf00025, Pf01926, Pf02421, Pf09439" 58477 ENSG00000144867.11 SRPRB 3 XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q00535 Cyclin-dependent-like kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3 0 4.92 9 3 5 2 292 33.3 7.66 1 3 1 4 1974451.406 2193443.672 3372815.031 3844581.906 2 3 3 3 cell communication;cell death;cell differentiation;cell division;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1020 ENSG00000164885.12 CDK5 7 Signaling by GPCR; DARPP-32 events; CRMPs in Sema3A signaling; Regulation of TP53 Activity through Phosphorylation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Factors involved in megakaryocyte development and platelet production Alzheimer's disease; Cocaine addiction; Axon guidance 1 High Q8NC51 Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2 0 7.719 9 3 5 3 408 44.9 8.65 2 2 1 2 2 1 1415389.219 1321233.688 2256142.719 957478.75 3 3 3 1 Met-loss [N-Term] regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf04774 26135 ENSG00000142864.14 SERBP1 1 0 High Q9UHI6 Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2 0 11.743 7 4 5 4 824 92.2 6.95 4 1 4 1 1421283.313 789737.25 217968.0156 300897.2813 2 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00270, Pf00271" 11218 ENSG00000064703.11 DDX20 1 snRNP Assembly RNA transport 0 High P28838 Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3 0 12.589 12 5 5 5 519 56.1 7.93 5 5 108719.3984 4340822.688 1 5 metabolic process cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;metal ion binding "Pf00883, Pf02789" 51056 ENSG00000002549.12 LAP3 4 Glutathione metabolism; Metabolic pathways; Arginine and proline metabolism 0 High P0DPK5 Histone H3.X OS=Homo sapiens OX=9606 GN=H3Y2 PE=5 SV=1 0 2.488 9 2 5 1 147 16.5 11.39 1 2 1 1 3 1 2264911.75 8302339 24100222 4285455.5 1 1 1 1 0 High P46109 Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1 0 6.614 12 3 5 3 303 33.8 6.74 3 1 4 1 427290.5156 2358573.344 1629883.125 640504.6719 2 3 3 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome protein binding;RNA binding;signal transducer activity "Pf00017, Pf00018, Pf07653, Pf14604" 1399 ENSG00000099942.12 CRKL 22 MET receptor recycling; Frs2-mediated activation; Regulation of signaling by CBL; MET activates RAP1 and RAC1; Downstream signal transduction Insulin signaling pathway; MicroRNAs in cancer; Chronic myeloid leukemia; Neurotrophin signaling pathway; Rap1 signaling pathway; MAPK signaling pathway; ErbB signaling pathway; Pathways in cancer; Renal cell carcinoma; Focal adhesion; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Fc gamma R-mediated phagocytosis; Chemokine signaling pathway; Shigellosis 0 High Q9NR28 "Diablo homolog, mitochondrial OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" 0 5.632 9 2 5 2 239 27.1 5.9 1 1 1 1 1 2 1 1 910706.6875 2311798 1617741.375 2593357.5 1 1 1 2 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion protein binding Pf09057 56616 ENSG00000184047.16 DIABLO 12 SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Release of apoptotic factors from the mitochondria Apoptosis - multiple species; Apoptosis 0 High P12270 Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3 0 5.815 2 3 4 3 2363 267.1 5.02 3 1 3 1 413469.625 172764.375 156802.8438 2 1 1 Met-loss+Acetyl [N-Term] cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity;transporter activity "Pf00038, Pf01496, Pf01576, Pf02463, Pf03961, Pf04111, Pf05911, Pf07888, Pf07926, Pf09726, Pf12128, Pf13166, Pf13514" 7175 ENSG00000047410.13 TPR 1 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins Pathways in cancer; RNA transport; Thyroid cancer 0 High P60413 Keratin-associated protein 10-12 OS=Homo sapiens OX=9606 GN=KRTAP10-12 PE=2 SV=1 0 6.232 11 2 4 2 245 25.1 7.5 2 4 6854342 2 cytosol 386685 ENSG00000189169.7 KRTAP10-12 21 Keratinization 0 High Q13503 Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1 0 8.64 26 2 4 2 144 15.6 4.45 1 1 1 1 1 2 370664.1484 700903.0156 578481.9609 702041.5547 2 2 2 2 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf11221 9412 ENSG00000152944.8 MED21 12 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q12904 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2 0 4.158 8 2 4 2 312 34.3 8.43 1 2 1 1 2 1 947094.8125 1141749.719 650828.3125 319447.875 2 2 1 1 cell communication;cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus protein binding;RNA binding Pf01588 9255 ENSG00000164022.16 AIMP1 4 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins 0 High Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=UGGT2 PE=1 SV=4 0 6.33 2 4 4 4 1516 174.6 6.89 4 4 2022044.469 3 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen catalytic activity;protein binding "Pf01501, Pf06427" 55757 ENSG00000102595.19 UGGT2 13 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High O95433 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1 0 3.734 6 2 4 2 338 38.3 5.53 2 2 2 2 218075.9258 947741.2813 1198548.844 2 2 2 regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum enzyme regulator activity;protein binding "Pf08327, Pf09229" 10598 ENSG00000100591.7 AHSA1 14 0 High Q15532 Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3 0 3.962 5 2 4 2 418 45.9 6.46 1 1 1 1 1 1 1 1 1454151.688 2108248.125 1143219.469 707839.8438 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding Pf05030 6760 ENSG00000141380.13 SS18 18 Transcriptional misregulation in cancer 0 High P49959 Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3 0 7.521 9 4 4 4 708 80.5 5.9 4 4 299263.3438 2766019.563 664727.125 476506.8281 1 3 2 2 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00149, Pf04152" 4361 ENSG00000020922.12 MRE11A; MRE11 11 G2/M DNA damage checkpoint; IRF3-mediated induction of type I IFN; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination; Non-homologous end-joining 0 High Q9NPA3 Mid1-interacting protein 1 OS=Homo sapiens OX=9606 GN=MID1IP1 PE=1 SV=1 0 5.111 17 3 4 3 183 20.2 5.5 3 4 2869973 203140.4688 3 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding Pf07084 58526 ENSG00000165175.15 MID1IP1 X Import of palmitoyl-CoA into the mitochondrial matrix 0 High O15226 NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2 0 4.601 3 2 4 2 690 77.6 8.79 2 1 1 2 1 1 348177.3125 941401.25 786543.0938 652317.0781 2 2 2 2 metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf01424, Pf01585, Pf12656" 55922 ENSG00000186416.13 NKRF X 0 High P28066 Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3 0 6.551 13 2 4 2 241 26.4 4.79 1 1 2 1 1 2 332572.2813 2816809.5 1924515.063 2024319.688 1 2 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome catalytic activity;nucleotide binding;protein binding "Pf00227, Pf10584" 5686 ENSG00000143106.12 PSMA5 1 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High P15531 Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1 0 6.042 22 3 4 3 152 17.1 6.19 2 2 2 2 445864.6563 398458.2969 2255524.875 928495.6563 2 2 3 2 cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00334 4830 ENSG00000239672.7 NME1 17 Interconversion of nucleotide di- and triphosphates Purine metabolism; Metabolic pathways; Pyrimidine metabolism 0 High P40939 "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" 0 4.202 3 2 4 2 763 82.9 9.04 2 2 2 2 592555.7969 572611.1094 1098719.094 517378.5938 2 2 2 1 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00378, Pf00725, Pf02737" 3030 ENSG00000084754.10 HADHA 2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Butanoate metabolism; Fatty acid degradation; Propanoate metabolism; Carbon metabolism; Lysine degradation; beta-Alanine metabolism; Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 High Q9BRJ7 Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1 0 5.036 13 2 4 2 211 23.3 8.91 2 2 2 2 530118.0469 663498.5 859911.8438 586271.875 2 2 2 2 regulation of biological process nucleus catalytic activity;protein binding;RNA binding 84309 ENSG00000168101.14 NUDT16L1 16 Proteoglycans in cancer 0 High Q08554 Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2 0 7.258 4 3 4 3 894 99.9 5.43 1 1 1 1 1 1 1 1 1554153.125 1476703.781 1875876.094 2080668.813 3 3 3 3 cell death;transport cytoskeleton;membrane metal ion binding "Pf00028, Pf01049, Pf08758" 1823 ENSG00000134765.9 DSC1 18 Formation of the cornified envelope; Neutrophil degranulation 0 High P51571 Translocon-associated protein subunit delta OS=Homo sapiens OX=9606 GN=SSR4 PE=1 SV=1 0 10.772 23 3 4 3 173 19 6.15 1 3 1 3 108697.9063 275488.0625 1195964.719 5308705.875 1 1 2 2 endoplasmic reticulum;membrane Pf05404 6748 ENSG00000180879.13 SSR4 X SRP-dependent cotranslational protein targeting to membrane Protein processing in endoplasmic reticulum 0 High P41091 Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3 0 6.085 7 2 4 2 472 51.1 8.4 2 2 2 2 798211.1875 1261225.75 1165756.094 1 2 2 Met-loss+Acetyl [N-Term] metabolic process;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03144, Pf09173" 1968 ENSG00000130741.10 EIF2S3 X "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition" RNA transport 0 High Q6UB35 "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" 0 6.513 4 4 4 4 978 105.7 8.06 4 4 2333419.5 1079383.438 993594.3125 4 4 4 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00763, Pf01268, Pf02882" 25902 ENSG00000120254.15 MTHFD1L 6 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 High Q07065 Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2 0 6.08 6 3 4 3 602 66 5.92 1 3 1 3 682579.7188 1312324.219 2441806.969 3788186.125 2 2 3 3 metabolic process;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;organelle lumen RNA binding Pf13166 10970 ENSG00000136026.13 CKAP4 12 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Surfactant metabolism; Neutrophil degranulation Protein processing in endoplasmic reticulum 0 High O14773 Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2 0 8.635 7 3 4 3 563 61.2 6.48 3 1 3 1 54694.88672 285808.7813 4396447.875 1158177.063 1 1 3 2 cell differentiation;cell organization and biogenesis;metabolic process mitochondrion;organelle lumen;vacuole catalytic activity;metal ion binding;protein binding Pf09286 1200 ENSG00000166340.15 TPP1 11 XBP1(S) activates chaperone genes Lysosome 0 High Q7L2E3 ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1 0 5.865 3 3 4 3 1194 133.9 8.78 3 1 3 1 479262.9063 644051.4063 911293.9688 421234.75 2 2 2 2 cell organization and biogenesis;metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717" 22907 ENSG00000132153.14 DHX30 3 0 High P32322 "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" 0 11.621 11 3 4 2 319 33.3 7.61 3 1 3 1 276450.25 4662502.188 1165039.625 811378.125 1 3 2 1 metabolic process;regulation of biological process;response to stimulus mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf01210, Pf03807, Pf14748" 5831 ENSG00000183010.16 PYCR1 17 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 1 High P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2 0 8.969 6 2 4 2 404 45.5 5.07 2 1 1 2 1 1 1945516 574985.2813 634732.4688 344979.9531 2 2 2 2 coagulation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00027, Pf02197" 5576 ENSG00000114302.15 PRKAR2A 3 DARPP-32 events; ROBO receptors bind AKAP5; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; PKA activation in glucagon signalling; PKA activation Insulin signaling pathway 0 High Q8N163 Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2 0 4.658 3 2 4 2 923 102.8 5.22 2 1 1 2 1 1 663951.0625 87046.375 303757.5 226814.0469 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;organelle lumen;spliceosomal complex enzyme regulator activity;protein binding;RNA binding "Pf14443, Pf14444" 57805 ENSG00000158941.16 CCAR2; KIAA1967 8 Regulation of HSF1-mediated heat shock response 0 High O43809 Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1 0 2.869 8 1 4 1 227 26.2 8.82 1 1 1 2 1 1 816663.0625 673552.9375 1006090.688 723874.5 1 1 1 1 cell organization and biogenesis;metabolic process nucleus catalytic activity;protein binding;RNA binding Pf13869 11051 ENSG00000167005.13 NUDT21 16 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High Q9ULH0 Kinase D-interacting substrate of 220 kDa OS=Homo sapiens OX=9606 GN=KIDINS220 PE=1 SV=3 0 7.323 4 4 4 4 1771 196.4 6.62 3 1 3 1 967125.3516 142983.5469 4 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytosol;endosome;membrane enzyme regulator activity;protein binding "Pf00023, Pf07693, Pf12796, Pf13606, Pf13637, Pf13857" 57498 ENSG00000134313.15 KIDINS220 2 ARMS-mediated activation Neurotrophin signaling pathway 0 High Q13867 Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1 0 6.694 7 3 4 3 455 52.5 6.27 3 4 2779295.125 2 Met-loss+Acetyl [N-Term] metabolic process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf03051 642 ENSG00000108578.14 BLMH 17 Antigen processing: Ubiquitination & Proteasome degradation 0 High P39748 Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1 0 2.785 4 2 4 2 380 42.6 8.62 1 1 2 1 1 2 342343.375 335703.7188 388074.6875 1172365.438 1 1 1 2 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00752, Pf00867, Pf01367" 2237 ENSG00000168496.3 FEN1 11 POLB-Dependent Long Patch Base Excision Repair; Early Phase of HIV Life Cycle; Removal of the Flap Intermediate; HDR through MMEJ (alt-NHEJ); PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate from the C-strand DNA replication; Non-homologous end-joining; Base excision repair 0 High Q16531 DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1 0 4.145 3 1 4 1 1140 126.9 5.26 1 1 1 1 1 1 1 1 606099.9688 577052.75 589346.875 992106.25 2 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding "Pf03178, Pf10433" 1642 ENSG00000167986.13 DDB1 11 Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation Viral carcinogenesis; Hepatitis B; Ubiquitin mediated proteolysis; Nucleotide excision repair 0 High O94952 F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21 PE=2 SV=2 0 5.152 4 1 4 1 628 72.2 6.09 1 1 1 1 1 2 1037554.438 1217822.375 1 1 metabolic process cytosol catalytic activity;DNA binding;protein binding "Pf08755, Pf12937, Pf13369" 23014 ENSG00000135108.14 FBXO21 12 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High Q9H3T3 Semaphorin-6B OS=Homo sapiens OX=9606 GN=SEMA6B PE=1 SV=4 0.006 1.892 3 1 4 1 888 95.2 8.48 1 1 1 3 21590110 14702815.94 10702450.94 8564492.188 1 1 1 1 cell differentiation;development membrane protein binding "Pf01403, Pf01437" 10501 ENSG00000167680.15 SEMA6B 19 Axon guidance 0 High Q969V3 Nicalin OS=Homo sapiens OX=9606 GN=NCLN PE=1 SV=2 0 9.531 6 2 4 2 563 62.9 6.89 2 1 3 1 59186.25391 1841526.313 1222268.813 1 2 2 metabolic process;regulation of biological process endoplasmic reticulum;membrane protein binding "Pf04389, Pf05450" 56926 ENSG00000125912.10 NCLN 19 0 High A8MUX0 Keratin-associated protein 16-1 OS=Homo sapiens OX=9606 GN=KRTAP16-1 PE=3 SV=1 0 6.151 13 3 4 3 517 53.9 5.39 3 4 1894954.125 14906648 1 3 cytosol Pf05287 100505753 ENSG00000263186.1; ENSG00000212657.1 KRTAP16-1 17; CHR_HSCHR17_1_CTG4 Keratinization 0 High Q9NRB3 Carbohydrate sulfotransferase 12 OS=Homo sapiens OX=9606 GN=CHST12 PE=2 SV=2 0 9.449 13 3 4 3 414 48.4 9.32 1 3 1 3 358408 611612.8906 1 2 metabolic process Golgi;membrane catalytic activity;nucleotide binding Pf03567 55501 ENSG00000136213.9 CHST12 7 Chondroitin sulfate biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High P11182 "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=3" 0 3.149 5 2 4 2 482 53.5 8.51 2 4 1818451.719 151051.2188 157685.375 204363.5781 2 1 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 1629 DBT 1 Branched-chain amino acid catabolism; Glyoxylate metabolism and glycine degradation "Propanoate metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation" 0 High Q96SN8 CDK5 regulatory subunit-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK5RAP2 PE=1 SV=5 0 6.397 3 3 4 3 1893 214.9 5.58 3 4 636226.2031 70217.13281 58410.10156 351562.5938 2 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;Golgi DNA binding;protein binding "Pf02463, Pf03962, Pf04111, Pf05557, Pf06160, Pf07989, Pf10174, Pf12128, Pf13166, Pf13514, Pf13949, Pf14817" 55755 ENSG00000136861.17 CDK5RAP2 9 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High P60660 Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2 0 7.151 34 4 4 4 151 16.9 4.65 2 1 1 2 1 1 425318 3077266.563 847791 634752.3125 1 2 1 1 cellular component movement cytosol;membrane catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity "Pf00036, Pf13405, Pf13499" 4637 ENSG00000092841.18 MYL6 12 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs Vascular smooth muscle contraction; Oxytocin signaling pathway 0 High Q9BY77 Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2 0 3.714 6 2 4 2 421 46.1 9.99 1 1 2 1 1 2 347263.6563 424770.0938 378728.5938 1 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 84271 ENSG00000100227.17 POLDIP3 22 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High Q15648 Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4 0 3.426 2 2 4 2 1581 168.4 8.73 1 1 2 1 1 2 317580.6875 393695.1875 397142.0625 1277035.125 1 1 1 2 cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport chromosome;membrane;nucleus catalytic activity;DNA binding;protein binding;receptor activity Pf10744 5469 ENSG00000125686.11 MED1 17 "Nuclear Receptor transcription pathway; Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; RORA activates gene expression; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription" Thyroid hormone signaling pathway; Endocrine resistance 0 High O60568 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1 0 5.758 5 3 4 3 738 84.7 6.05 1 1 2 1 1 2 478518.1719 374108.3438 744498 1442816.063 2 1 1 2 cell organization and biogenesis;metabolic process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding Pf03171 8985 ENSG00000106397.11 PLOD3 7 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 0 High Q9BZQ6 ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2 0 7.508 5 4 4 4 932 104.6 4.93 4 4 2501082.906 489520.4688 4 2 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding "Pf01532, Pf02225" 80267 ENSG00000116406.18 EDEM3 1 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High O15173 Membrane-associated progesterone receptor component 2 OS=Homo sapiens OX=9606 GN=PGRMC2 PE=1 SV=1 0 5.619 16 3 4 2 223 23.8 4.88 3 4 174395.0625 140641.1563 1 1 regulation of biological process;response to stimulus membrane protein binding;receptor activity;signal transducer activity Pf00173 10424 ENSG00000164040.16 PGRMC2 4 0 High P67870 Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1 0 3.176 5 1 4 1 215 24.9 5.55 1 1 1 1 1 1 1 1 403781.7188 684904.5625 534806.625 408399.0313 1 1 1 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;enzyme regulator activity;metal ion binding;protein binding Pf01214 1460 ENSG00000224774.7; ENSG00000230700.9; ENSG00000206406.9; ENSG00000204435.13; ENSG00000232960.10; ENSG00000224398.7; ENSG00000228875.8 CSNK2B 6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1 WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Neutrophil degranulation; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation Tight junction; Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Wnt signaling pathway; Adherens junction; Measles; Herpes simplex infection 0 High P26368 Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4 0 7.01 8 3 4 3 475 53.5 9.09 1 2 1 3 3956219.656 2733724.125 4117981.625 2124410.219 3 3 3 3 metabolic process;regulation of biological process;transport nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 11338 ENSG00000063244.12 U2AF2 19 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome 0 High P42771 Cyclin-dependent kinase inhibitor 2A OS=Homo sapiens OX=9606 GN=CDKN2A PE=1 SV=2 0 5.296 8 1 4 1 156 16.5 5.81 1 1 1 1 1 1 1 1 378554.125 537753 671486.125 406595.2188 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;protein binding;RNA binding "Pf12796, Pf13637, Pf13857" 1029 ENSG00000147889.17 CDKN2A 9 Cyclin D associated events in G1; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence Viral carcinogenesis; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Non-small cell lung cancer; Pathways in cancer; Glioma; Melanoma; HTLV-I infection; p53 signaling pathway; Bladder cancer; Cell cycle; Endocrine resistance; Platinum drug resistance 0 High O00422 Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1 0 2.667 9 2 4 2 153 17.6 9.35 1 2 1 1 2 1 1675219.281 1491047.344 1580094.938 1816412.063 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus catalytic activity;protein binding;RNA binding Pf06487 10284 ENSG00000150459.12 SAP18 13 HDACs deacetylate histones; NoRC negatively regulates rRNA expression mRNA surveillance pathway; RNA transport 0 High P25440 Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2 0 5.707 4 3 4 1 801 88 9.09 1 1 2 1 1 2 390086.5625 346404.9063 311179.6875 226794.375 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding Pf00439 6046 ENSG00000204256.12; ENSG00000235307.9; ENSG00000234507.9; ENSG00000215077.10 BRD2 6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1 RUNX3 regulates p14-ARF 0 High Q8IYH5 ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1 0 4.37 3 2 4 2 903 102 5.69 1 2 1 1 2 1 102970.7188 3440572.438 2969606.063 2605534.344 1 2 2 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00249, Pf00569" 26009 ENSG00000036549.12 ZZZ3 1 HATs acetylate histones 0 High O15042 U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2 0 4.564 2 2 4 2 1029 118.2 8.47 1 2 1 1 2 1 677910.375 703056.1875 987473.375 501352.9063 2 2 2 1 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf01805, Pf08312, Pf13893, Pf14259" 23350 ENSG00000163714.17 U2SURP 3 mRNA Splicing - Major Pathway Spliceosome 0 High Q9Y294 Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1 0 6.784 11 2 4 2 204 23 4.41 1 1 2 1 1 2 747296.75 930678.625 2367678.25 2590283.375 2 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding Pf04729 25842 ENSG00000111875.7 ASF1A 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0 High Q99832 T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2 0 5.075 7 3 4 3 543 59.3 7.65 1 2 1 1 2 1 604237.0625 587237.9375 968969.2188 918908.7969 2 2 2 3 metabolic process;regulation of biological process;transport cytoplasm;cytosol;mitochondrion nucleotide binding;protein binding Pf00118 10574 ENSG00000135624.15 CCT7 2 Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High P62875 "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" 0.001 2.242 13 1 4 1 67 7.6 7.77 1 1 1 1 1 1 1 1 458974.3438 418362.8438 565826.9375 471091.7813 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf01194 5441 ENSG00000177700.5 POLR2L 11 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High Q6ZUT1 Uncharacterized protein NKAPD1 OS=Homo sapiens OX=9606 GN=NKAPD1 PE=1 SV=2 0 5.48 8 2 4 2 292 34.1 9.73 1 1 2 1 1 2 796255.6563 1101491.094 1017447.656 375514.125 2 2 2 1 protein binding 55216 ENSG00000150776.17 C11orf57; NKAPD1 11 0 High P08574 "Cytochrome c1, heme protein, mitochondrial OS=Homo sapiens OX=9606 GN=CYC1 PE=1 SV=3" 0 4.881 4 2 4 2 325 35.4 9 2 1 3 1 53802.03906 1083268.813 1002580.281 1 2 2 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus metal ion binding Pf02167 1537 ENSG00000179091.4 CYC1 8 Respiratory electron transport; Mitochondrial protein import; Metabolism of proteins Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 High O60885 Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2 0 7.624 3 4 4 2 1362 152.1 9.19 1 2 1 1 2 1 760066.4375 542407.2031 916391.0469 576581.3125 1 2 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus protein binding Pf00439 23476 ENSG00000141867.17 BRD4 19 1 Medium P47914 60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2 0.015 1.42 5 1 4 1 159 17.7 11.66 1 1 1 1 1 1 1 1 1191973.5 2145392 2608365 2060670.25 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytosol;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01779 6159 ENSG00000162244.10 RPL29 3 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P07195 L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2 0 4.409 6 2 4 2 334 36.6 6.05 1 2 1 1 2 1 948826.2813 2227078.438 732380.8594 2 2 2 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 3945 ENSG00000111716.12 LDHB 12 Pyruvate metabolism Propanoate metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Cysteine and methionine metabolism 0 High Q8N1F7 Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2 0 5.245 3 3 4 3 819 93.4 5.72 1 3 1 3 479904.3594 297071.9375 337085.4688 889531.2813 2 1 1 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;nucleus protein binding;structural molecule activity Pf04097 9688 ENSG00000102900.12 NUP93 16 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q14566 DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1 0 5.331 4 3 4 3 821 92.8 5.41 2 2 2 2 139131.7344 142299.4219 186613.625 122370.5938 1 1 1 1 metabolic process nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf01078, Pf07728, Pf14551" 4175 ENSG00000076003.4 MCM6 2 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q9BQ67 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1 0 2.63 3 1 4 1 446 49.4 4.92 1 1 1 1 1 1 1 1 331138.6875 419293.5313 581166.1875 447421.125 1 1 1 1 cell organization and biogenesis;metabolic process chromosome;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00400, Pf12265" 83743 ENSG00000105447.12 GRWD1 19 0 High O75746 Calcium-binding mitochondrial carrier protein Aralar1 OS=Homo sapiens OX=9606 GN=SLC25A12 PE=1 SV=2 0 3.81 3 2 4 1 678 74.7 8.38 1 1 2 1 1 2 metabolic process;response to stimulus;transport membrane;mitochondrion metal ion binding;transporter activity "Pf00153, Pf13499" 8604 ENSG00000115840.13 SLC25A12 2 Gluconeogenesis; Mitochondrial protein import; Metabolism of proteins 0 High O43150 "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ASAP2 PE=1 SV=3" 0.001 2.372 1 1 4 1 1006 111.6 6.68 1 1 1 1 1 2 118588361.6 106407346.7 120263792.2 193741050 2 2 2 2 regulation of biological process cytoplasm;Golgi;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00018, Pf00023, Pf00169, Pf01412, Pf07653, Pf12796, Pf13637, Pf13857, Pf14604" 8853 ENSG00000151693.9 ASAP2 2 Endocytosis; Fc gamma R-mediated phagocytosis 0 High Q02383 Semenogelin-2 OS=Homo sapiens OX=9606 GN=SEMG2 PE=1 SV=1 0 9.379 8 3 4 2 582 65.4 9.07 3 4 1278780.25 2 cell organization and biogenesis;coagulation;defense response;regulation of biological process;response to stimulus extracellular;nucleus metal ion binding;protein binding Pf05474 6407 ENSG00000124157.6 SEMG2 20 0 High A5YKK6 CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 0 5.615 1 3 3 3 2376 266.8 7.11 3 3 827197.9375 273250.7344 182659.4063 148712.7813 2 2 1 1 development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding;RNA binding;structural molecule activity "Pf04054, Pf12842" 23019 ENSG00000125107.17 CNOT1 16 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA RNA degradation 0 High Q9UQE7 Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2 0 2.674 2 2 3 2 1217 141.5 7.18 2 1 2 1 188438.4375 196952.6875 980576.2813 1196639.469 1 1 2 2 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf01496, Pf02463, Pf04111, Pf06470, Pf10168, Pf12128, Pf13304, Pf13476, Pf13555" 9126 ENSG00000108055.9 SMC3 10 Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 Medium Q9H0D6 5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1 0.018 1.371 1 1 3 1 950 108.5 7.47 1 1 1 1 1 1 194544.5156 459972.9063 296429.3438 312339.4063 1 1 1 1 Met-loss [N-Term] cell differentiation;metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding Pf03159 22803 ENSG00000088930.7 XRN2 20 Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis Ribosome biogenesis in eukaryotes; RNA degradation 0 High O00562 Membrane-associated phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNM1 PE=1 SV=4 0 5.302 2 3 3 2 1244 134.8 5.95 2 1 2 1 1219276.5 401364.5625 304992.2188 2 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane metal ion binding;protein binding;transporter activity "Pf02121, Pf02862, Pf08235" 9600 ENSG00000110697.12 PITPNM1 11 Synthesis of PI 0 High P55735 Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3 0.004 1.989 2 1 3 1 322 35.5 5.48 1 1 1 1 1 1 649161.9375 566547.9375 787407.625 1 1 1 cell organization and biogenesis;regulation of biological process;transport chromosome;cytosol;endoplasmic reticulum;membrane;nucleus;vacuole protein binding Pf00400 6396 ENSG00000157020.17 SEC13 3 "COPII (Coat Protein 2) Mediated Vesicle Transport; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RHO GTPases Activate Formins; MHC class II antigen presentation" Protein processing in endoplasmic reticulum; mTOR signaling pathway; RNA transport 0 High P19388 "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" 0 3.091 9 2 3 2 210 24.5 5.95 2 1 2 1 5228214.156 18161246.69 7212313 21120330 2 2 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf01191, Pf03871" 5434 ENSG00000099817.11 POLR2E 19 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2 0 4.945 3 2 3 2 812 89.2 9.23 2 1 2 1 372436.1875 738660.8281 1043599.438 688437.0625 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;protein binding;RNA binding "Pf01189, Pf12847" 4839 ENSG00000111641.11 NOP2 12 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; rRNA modification in the nucleus and cytosol 0 High Q14574 Desmocollin-3 OS=Homo sapiens OX=9606 GN=DSC3 PE=1 SV=3 0 9.048 6 3 3 3 896 99.9 6.1 3 3 926784.1875 2073022.25 308751.2188 1 2 1 cell death;regulation of biological process cytoskeleton;membrane metal ion binding;protein binding "Pf00028, Pf01049, Pf08758" 1825 ENSG00000134762.16 DSC3 18 Formation of the cornified envelope 0 High P53621 Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2 0 5.975 2 2 3 2 1224 138.3 7.66 1 2 1 2 313224.9375 627101.1875 550502.375 1386005.75 1 1 1 2 regulation of biological process;transport cytoplasm;cytosol;extracellular;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053, Pf06957" 1314 ENSG00000122218.14 COPA 1 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 High Q01085 Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1 0.007 1.677 2 1 3 1 375 41.6 7.74 1 1 1 1 1 1 192427.0156 298793.7813 339000.375 201736.2969 1 1 1 1 cell death;cell division;defense response;regulation of biological process;response to stimulus cytoplasm;nucleus;vacuole DNA binding;RNA binding "Pf00076, Pf13893, Pf14259" 7073 ENSG00000151923.17 TIAL1 10 FGFR2 alternative splicing 0 High Q9P0T7 Transmembrane protein 9 OS=Homo sapiens OX=9606 GN=TMEM9 PE=1 SV=1 0 5.507 11 2 3 2 183 20.6 6.65 2 1 2 1 331590.6563 10130069 2149676.875 1 2 2 transport endosome;membrane;vacuole Pf05434 252839 ENSG00000116857.16 TMEM9 1 0 High P33240 Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1 0 7.845 7 3 3 3 577 60.9 6.83 3 3 2280055 103193.6172 70776.89063 2 1 1 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259, Pf14304, Pf14327" 1478 ENSG00000101811.13 CSTF2 X Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway; tRNA processing in the nucleus mRNA surveillance pathway 0 High P32969 60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1 0 3.168 5 1 3 1 192 21.9 9.95 1 1 1 1 1 1 704451.1875 1300806.5 1654152.625 706672.875 1 1 1 1 cell organization and biogenesis;metabolic process;transport cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00347 6133 ENSG00000163682.15 RPL9 4 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9Y4A8 Nuclear factor erythroid 2-related factor 3 OS=Homo sapiens OX=9606 GN=NFE2L3 PE=1 SV=1 0 2.785 6 1 3 1 694 76.1 5.44 1 1 1 2 metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf07716" 9603 ENSG00000050344.8 NFE2L3 7 0 High Q99941 Cyclic AMP-dependent transcription factor ATF-6 beta OS=Homo sapiens OX=9606 GN=ATF6B PE=1 SV=2 0 8.853 2 1 3 1 703 76.7 6.27 1 1 1 2 69555.03125 293457.3906 1 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane;nucleus DNA binding;protein binding "Pf00170, Pf07716" 1388 ENSG00000228628.8; ENSG00000234539.9; ENSG00000213676.10; ENSG00000168468.12 ATF6B 6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1 Viral carcinogenesis; Dopaminergic synapse; TNF signaling pathway; Hepatitis B; Amphetamine addiction; cGMP-PKG signaling pathway; Protein processing in endoplasmic reticulum; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Aldosterone synthesis and secretion; Cocaine addiction; Alcoholism; Estrogen signaling pathway; Longevity regulating pathway; PI3K-Akt signaling pathway 0 High Q6UWL2 Sushi domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUSD1 PE=1 SV=1 0 6.192 4 3 3 3 747 82.7 6.43 3 3 2458433.469 3 cell surface;membrane metal ion binding;protein binding "Pf00008, Pf00084, Pf06247, Pf07645, Pf12947" 64420 ENSG00000106868.16 SUSD1 9 0 High Q9UBS4 DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1 0 2.718 10 2 3 2 358 40.5 6.18 1 2 1 2 829838.2188 377691.3984 1101005.563 2 2 2 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen protein binding "Pf00226, Pf01556" 51726 ENSG00000090520.11 DNAJB11 3 XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum 0 High Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1 0 4.443 14 2 3 2 163 18.2 8.82 2 1 2 1 583839.7031 410843.2891 626779.6094 157099.7969 2 2 2 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;motor activity;protein binding;transporter activity "Pf00397, Pf00639, Pf13616" 5300 ENSG00000127445.13 PIN1 19 ISG15 antiviral mechanism; PI5P Regulates TP53 Acetylation; Negative regulators of DDX58/IFIH1 signaling; Regulation of TP53 Activity through Phosphorylation RIG-I-like receptor signaling pathway 0 High Q9Y285 Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3 0 4.879 4 2 3 2 508 57.5 7.8 1 1 1 1 1 1 449344.2578 482126.4531 1709403.75 3418871 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00152, Pf01409, Pf08279, Pf12802, Pf13463" 2193 ENSG00000179115.10 FARSA 19 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 Medium Q13190 Syntaxin-5 OS=Homo sapiens OX=9606 GN=STX5 PE=1 SV=2 0.041 1.137 2 1 3 1 355 39.6 9.16 1 1 2 1 553620.3125 606964.25 689951.25 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytosol;endoplasmic reticulum;Golgi;membrane protein binding "Pf00804, Pf05739" 6811 ENSG00000162236.11 STX5 11 COPI-mediated anterograde transport; Intra-Golgi traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport SNARE interactions in vesicular transport 0 High O95831 "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" 0 11.833 5 2 3 2 613 66.9 8.95 2 3 5040659.813 1182050.188 1085864.5 1995240.75 2 2 1 1 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00070, Pf07992, Pf14721, Pf14962" 9131 ENSG00000156709.13 AIFM1 X Apoptosis 0 High P18850 Cyclic AMP-dependent transcription factor ATF-6 alpha OS=Homo sapiens OX=9606 GN=ATF6 PE=1 SV=3 0 4.52 3 2 3 2 670 74.5 8.22 1 2 1 2 88603.09375 228311.6406 432988.1875 2158907.438 1 1 1 2 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;Golgi;membrane;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf06156, Pf07716" 22926 ENSG00000118217.5 ATF6 1 ATF4 activates genes; ATF6 (ATF6-alpha) activates chaperone genes Protein processing in endoplasmic reticulum; Alzheimer's disease 0 High Q5BLP8 Neuropeptide-like protein C4orf48 OS=Homo sapiens OX=9606 GN=C4orf48 PE=1 SV=3 0 4.329 19 2 3 2 95 10.2 8.31 2 3 1643007.875 1 extracellular Pf15161 401115 ENSG00000243449.6 C4orf48 4 0 High Q16629 Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1 0 5.878 13 3 3 3 238 27.4 11.82 2 1 2 1 2559926.969 2916269.063 3359461.625 305061 3 2 3 1 metabolic process;regulation of biological process;transport cytoplasm;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6432 ENSG00000115875.18 SRSF7 2 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High Q9BWS9 Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1 0 5.177 7 3 3 3 393 44.9 8.63 3 3 244952.75 1451172.25 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport endosome;extracellular;membrane;nucleus;organelle lumen;vacuole catalytic activity;protein binding Pf00704 66005 ENSG00000177830.17 CHID1 11 Platelet degranulation 0 High O15260 Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3 0 8.25 11 2 3 2 269 30.4 7.78 2 1 2 1 420984.375 847131.125 191625.7031 1 1 1 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf02077 6836 ENSG00000280951.2; ENSG00000148248.13 SURF4 9; CHR_HG2030_PATCH COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation 0 High Q53H96 Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3 0 6.284 13 3 3 3 274 28.6 7.72 3 3 2285731.313 746995.3594 765834.7344 168721.8438 3 2 2 1 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf03807, Pf14748" 65263 ENSG00000276657.2; ENSG00000104524.13 PYCRL; PYCR3 8; CHR_HSCHR8_3_CTG7 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High O00159 Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4 0 6.001 3 3 3 3 1063 121.6 9.41 1 2 1 2 1429498.188 957181.875 3 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 4641 ENSG00000197879.14 MYO1C 17 Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation 0 High Q9NWB6 Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1 0.006 1.865 3 1 3 1 273 33.2 10.35 1 1 1 1 1 1 562763.25 393719 832237.3125 820364.75 1 1 1 1 metabolic process;regulation of biological process mitochondrion;nucleus protein binding Pf15346 55082 ENSG00000134884.13 ARGLU1 13 0 High Q14683 Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2 0 3.611 1 2 3 2 1233 143.1 7.64 1 1 1 1 1 1 616309.7813 820119.3125 967669.3125 929848.5938 2 2 2 2 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus nucleotide binding;protein binding;RNA binding "Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558" 8243 ENSG00000072501.17 SMC1A X Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 High P55084 "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" 0 5.246 4 2 3 2 474 51.3 9.41 1 2 1 2 660581.8984 357210.6641 1375021.844 583776.5469 3 3 3 3 metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;protein binding;RNA binding "Pf00108, Pf00109, Pf02803" 3032 ENSG00000138029.13 HADHB 2 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Fatty acid degradation; Fatty acid elongation; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 High P61009 Signal peptidase complex subunit 3 OS=Homo sapiens OX=9606 GN=SPCS3 PE=1 SV=1 0 9.775 18 3 3 3 180 20.3 8.62 3 3 13131137.38 2 metabolic process;transport endoplasmic reticulum;membrane catalytic activity Pf04573 60559 ENSG00000129128.12 SPCS3 4 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)" Protein export 0 High P35659 Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1 0 3.889 5 2 3 2 375 42.6 8.56 1 1 1 1 1 1 1558932.813 923031.7813 1282922.625 418015.5 2 2 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf02037, Pf08766" 7913 ENSG00000124795.14 DEK 6 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; B-WICH complex positively regulates rRNA expression 0 High Q9Y3F4 Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1 0 6.57 11 3 3 3 350 38.4 5.12 2 1 2 1 968500.9688 269968.8438 768353.9375 684135 2 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding Pf00400 11171 ENSG00000023734.10 STRAP 12 Downregulation of TGF-beta receptor signaling RNA transport 0 High P28300 Protein-lysine 6-oxidase OS=Homo sapiens OX=9606 GN=LOX PE=1 SV=2 0.007 1.685 2 1 3 1 417 46.9 8.09 1 1 1 2 600395.625 1130226.625 1 1 cell organization and biogenesis;metabolic process;response to stimulus extracellular;nucleus catalytic activity;metal ion binding;protein binding Pf01186 4015 ENSG00000113083.13 LOX 5 Elastic fibre formation; Crosslinking of collagen fibrils 0 High Q5BKZ1 DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2 0 4.152 5 3 3 3 582 65.6 5.15 1 2 1 2 638618.5938 1229068.813 718463.1563 538165.3125 2 2 2 1 metabolic process;regulation of biological process nucleus;spliceosomal complex DNA binding;metal ion binding;protein binding;RNA binding Pf04988 284695 ENSG00000162664.16 ZNF326 1 0 Medium H3BSY2 Golgin subfamily A member 8M OS=Homo sapiens OX=9606 GN=GOLGA8M PE=3 SV=1 0.049 1.036 1 1 3 1 632 71.5 7.11 1 1 1 1 1 1 768813.75 346019.5313 379991.75 1 1 1 transport Golgi "Pf09730, Pf15070" 653720 ENSG00000188626.6 GOLGA8M 15 0 High Q13435 Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2 0 3.674 2 2 3 2 895 100.2 5.67 1 1 1 1 1 1 524296.6563 724926.3125 763955.9375 850163.125 2 2 2 2 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf02037, Pf04037, Pf04046" 10992 ENSG00000087365.15 SF3B2 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q6UWY0 Arylsulfatase K OS=Homo sapiens OX=9606 GN=ARSK PE=1 SV=1 0 5.205 9 3 3 3 536 61.4 8.92 3 3 293607.2188 1969034.406 1 3 metabolic process extracellular;organelle lumen catalytic activity;metal ion binding "Pf00884, Pf01676" 153642 ENSG00000164291.16 ARSK 5 The activation of arylsulfatases; Glycosphingolipid metabolism 0 High P60014 Keratin-associated protein 10-10 OS=Homo sapiens OX=9606 GN=KRTAP10-10 PE=1 SV=1 0 9.924 20 2 3 2 251 25.6 7.06 2 3 15907847 9320734.875 3955225 1 2 1 cytosol 353333 ENSG00000221859.2 KRTAP10-10 21 Keratinization 0 High Q8IZ83 Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2 0 5.409 5 3 3 3 802 85.1 6.79 3 3 2115920.063 185295.8125 3 1 metabolic process membrane catalytic activity "Pf00171, Pf07368" 126133 ENSG00000161618.9 ALDH16A1 19 0 High Q04726 Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2 0 7.451 6 3 3 2 772 83.4 7.2 3 3 3963981.25 2 metabolic process;regulation of biological process;response to stimulus nucleus protein binding "Pf00400, Pf03920" 7090 ENSG00000140332.15 TLE3 15 Repression of WNT target genes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex 1 High Q58FF8 Putative heat shock protein HSP 90-beta 2 OS=Homo sapiens OX=9606 GN=HSP90AB2P PE=1 SV=2 0 9.244 8 2 3 1 381 44.3 4.84 2 1 2 1 365387.6563 1 metabolic process;response to stimulus cytoplasm nucleotide binding;protein binding "Pf00183, Pf02518" 391634 HSP90AB2P 4 0 High P00338 L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2 0 6.355 8 3 3 3 332 36.7 8.27 3 3 1907286.875 350225.25 3 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 3939 ENSG00000134333.13 LDHA 11 Pyruvate metabolism Propanoate metabolism; HIF-1 signaling pathway; Central carbon metabolism in cancer; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Cysteine and methionine metabolism 0 High P23528 Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3 0 5.102 13 2 3 2 166 18.5 8.09 2 1 2 1 562257.0625 1316755.625 3251346.5 1991971.938 1 2 2 2 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding Pf00241 1072 ENSG00000172757.12 CFL1 11 Platelet degranulation ; Sema3A PAK dependent Axon repulsion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Interleukin-12 family signaling Pertussis; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Axon guidance 0 High Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3 0 5.718 8 2 3 2 261 26.9 7.78 2 3 357781.5938 230848.0625 1854884.688 357207.7891 1 1 3 2 cell organization and biogenesis;metabolic process cytoplasm;membrane;mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding "Pf00106, Pf08659, Pf13561" 3028 ENSG00000072506.12 HSD17B10 X tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; Branched-chain amino acid catabolism; tRNA modification in the mitochondrion "Alzheimer's disease; Metabolic pathways; Valine, leucine and isoleucine degradation" 0 High O95816 BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1 0 3.233 7 1 3 1 211 23.8 6.7 1 1 1 1 1 1 218980.0781 434101.5625 492313.4375 348796.5 1 1 1 1 metabolic process;regulation of biological process cytosol enzyme regulator activity;nucleotide binding;protein binding Pf02179 9532 ENSG00000112208.11 BAG2 6 Regulation of HSF1-mediated heat shock response Protein processing in endoplasmic reticulum 0 High P17980 26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3 0 6.364 5 1 3 1 439 49.2 5.24 1 1 1 1 1 1 277956.0625 273989.25 117633.875 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00004, Pf01078, Pf05496, Pf07724, Pf07728, Pf13191" 5702 ENSG00000165916.8 PSMC3 11 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 High Q5W0B1 ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1 0 4.522 3 3 3 3 726 81.1 5.72 2 1 2 1 856185.8594 564680.6563 229967.6719 245150.3906 2 2 1 1 metal ion binding;protein binding "Pf00097, Pf12678, Pf13639, Pf13920, Pf13923" 79596 ENSG00000152193.7 RNF219 13 0 High Q02809 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2" 0 8.152 4 2 3 2 727 83.5 6.95 1 2 1 2 512111.8438 1 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf03171 5351 ENSG00000083444.16 PLOD1 1 Collagen biosynthesis and modifying enzymes Lysine degradation 0 High P11310 "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" 0 4.03 6 2 3 2 421 46.6 8.37 1 1 1 1 1 1 110291.1953 568096.1563 673172.2188 650898.2813 1 2 2 2 metabolic process;regulation of biological process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00441, Pf02770, Pf02771, Pf08028, Pf11794" 34 ENSG00000117054.13 ACADM 1 PPARA activates gene expression; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA "Fatty acid degradation; Propanoate metabolism; Carbon metabolism; PPAR signaling pathway; beta-Alanine metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 High Q9Y2G5 GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3 0 7.669 8 3 3 3 429 49.9 6.6 3 3 204769.8438 152332.0625 1736726.031 1 1 3 metabolic process;regulation of biological process endoplasmic reticulum;Golgi;membrane catalytic activity Pf10250 23275 ENSG00000186866.16 POFUT2 21 O-glycosylation of TSR domain-containing proteins Other types of O-glycan biosynthesis 0 High Q5JWF2 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2 0 4.875 3 2 3 2 1037 111 5.03 2 1 2 1 299942.0313 2884229.125 1184205.75 864365.9375 1 2 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503, Pf08477" 2778 ENSG00000087460.24 GNAS 20 G alpha (z) signalling events; Prostacyclin signalling through prostacyclin receptor; PKA activation in glucagon signalling; G alpha (s) signalling events; Glucagon-type ligand receptors; G alpha (i) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins 0 High Q9UBX3 Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 GN=SLC25A10 PE=1 SV=2 0.004 2.012 4 1 3 1 287 31.3 9.54 1 1 1 1 1 1 104100.625 163714.9531 513971.0625 542038.75 1 1 1 1 metabolic process;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 1468 ENSG00000183048.11 SLC25A10 17 Gluconeogenesis; Sulfide oxidation to sulfate; Organic anion transporters Proximal tubule bicarbonate reclamation 0 High Q96C36 Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1 0 5.495 10 2 3 1 320 33.6 7.77 2 3 900755 309026.0313 355990.9688 1 1 1 metabolic process;response to stimulus cytoplasm;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf01210, Pf03807, Pf14748" 29920 ENSG00000143811.18 PYCR2 1 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 High P06280 Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1 0 6.175 7 2 3 2 429 48.7 5.6 2 3 811148.1875 1 metabolic process;regulation of biological process;transport cytoplasm;extracellular;Golgi;organelle lumen;vacuole catalytic activity;protein binding Pf02065 2717 ENSG00000102393.9 GLA X Glycosphingolipid metabolism; Neutrophil degranulation Lysosome; Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis - globo and isoglobo series 0 High Q9BX67 Junctional adhesion molecule C OS=Homo sapiens OX=9606 GN=JAM3 PE=1 SV=1 0 3.65 8 2 3 2 310 35 7.59 2 3 97664.32813 1774495.125 275751.3438 1 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927" 83700 ENSG00000166086.12 JAM3 11 Integrin cell surface interactions; Cell surface interactions at the vascular wall Tight junction; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection 0 High Q13308 Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2 0 5.086 2 2 3 2 1070 118.3 7.09 1 2 1 2 628925.3125 1328117.188 1 2 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding "Pf00047, Pf00069, Pf07679, Pf07714, Pf13895, Pf13927, Pf14575" 5754 ENSG00000112655.15 PTK7 6 0 High P05166 "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3" 0 9.106 3 1 3 1 539 58.2 7.64 1 1 1 1 1 1 metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding Pf01039 5096 ENSG00000114054.13 PCCB 3 Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism "Propanoate metabolism; Carbon metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Valine, leucine and isoleucine degradation" 0 High Q9Y4Z0 U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1 0.007 1.647 6 1 3 1 139 15.3 9.99 1 1 1 1 1 1 434665.9063 549751.1875 441064.375 276198.5938 1 1 1 1 Met-loss [N-Term] cell organization and biogenesis;metabolic process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 25804 ENSG00000130520.10 LSM4 19 mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease Spliceosome; RNA degradation 0 High Q8TBC3 SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2 0 4.223 5 3 3 3 707 76.3 8.28 3 3 2070058.906 134103.0938 3 1 cell organization and biogenesis;regulation of biological process vacuole protein binding Pf02214 92799 ENSG00000160410.14 SHKBP1 19 0 High O00165 HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2 0 3.838 7 2 3 2 279 31.6 4.92 1 1 1 1 1 1 532936.4063 591615.2344 159394.1875 339683.375 2 2 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus protein binding 10456 ENSG00000143575.14 HAX1 1 0 High Q99720 Sigma non-opioid intracellular receptor 1 OS=Homo sapiens OX=9606 GN=SIGMAR1 PE=1 SV=1 0 4.882 9 2 3 2 223 25.1 5.96 2 3 2003175.813 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;nucleus protein binding;receptor activity;signal transducer activity Pf04622 10280 ENSG00000147955.16 SIGMAR1 9 0 High P30837 "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=3" 0 5.193 9 3 3 2 517 57.2 6.8 1 1 1 1 1 1 169404.2969 201946.25 891759.4688 531122.125 1 1 2 1 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding Pf00171 219 ALDH1B1 9 Ethanol oxidation "Fatty acid degradation; Ascorbate and aldarate metabolism; Lysine degradation; Histidine metabolism; beta-Alanine metabolism; Pyruvate metabolism; Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Metabolic pathways; Tryptophan metabolism; Arginine and proline metabolism; Valine, leucine and isoleucine degradation" 1 High Q6ZSR9 Uncharacterized protein FLJ45252 OS=Homo sapiens OX=9606 PE=2 SV=2 0 7.851 13 3 3 3 355 38 5.26 2 1 2 1 539961.6875 1623436.625 871637.8125 1 2 1 Pf15282 0 High P40227 T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3 0 2.551 5 2 3 2 531 58 6.68 1 1 1 1 1 1 286208.6875 360798.625 536084.875 100053.8828 1 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane nucleotide binding;protein binding;RNA binding "Pf00118, Pf05504" 908 ENSG00000146731.10 CCT6A 7 Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High P60410 Keratin-associated protein 10-8 OS=Homo sapiens OX=9606 GN=KRTAP10-8 PE=1 SV=2 0 11.909 18 2 3 2 259 26.3 7.42 2 3 1000324.563 2 cytosol protein binding 386681 ENSG00000187766.1 KRTAP10-8 21 Keratinization 0 High Q9BZM1 Group XIIA secretory phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G12A PE=1 SV=1 0 11.692 20 2 3 2 189 21.1 7.24 2 3 1476196.563 1 metabolic process;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi catalytic activity;metal ion binding Pf06951 81579 ENSG00000123739.10 PLA2G12A 4 Acyl chain remodelling of PI; Synthesis of PA; Acyl chain remodelling of PG; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC Fat digestion and absorption; Ether lipid metabolism; Vascular smooth muscle contraction; Arachidonic acid metabolism; Linoleic acid metabolism; Pancreatic secretion; Glycerophospholipid metabolism; Ras signaling pathway; alpha-Linolenic acid metabolism; Metabolic pathways 0 Medium O60437 Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4 0.047 1.068 1 1 3 1 1756 204.6 5.6 1 1 2 1 260984351.9 241267990 192248844.8 267727519.3 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus protein binding;structural molecule activity Pf04111 5493 ENSG00000118898.15 PPL 16 Butyrophilin (BTN) family interactions; Formation of the cornified envelope 0 High P14174 Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4 0 3.46 10 1 3 1 115 12.5 7.88 1 3 3331990.5 1 Met-loss [N-Term] cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;extracellular;organelle lumen catalytic activity;protein binding Pf01187 4282 ENSG00000276701.2; ENSG00000240972.1 MIF 22; CHR_HSCHR22_1_CTG7 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Neutrophil degranulation; Interleukin-12 family signaling; Cell surface interactions at the vascular wall Tyrosine metabolism; Phenylalanine metabolism 0 High A8MVA2 Keratin-associated protein 9-6 OS=Homo sapiens OX=9606 GN=KRTAP9-6 PE=3 SV=1 0 12.515 9 1 3 1 160 16.8 7.55 1 3 26629015.25 2 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cytosol 100507608 ENSG00000263263.1; ENSG00000212659.1 KRTAP9-6 17; CHR_HSCHR17_6_CTG4 Keratinization 0 High Q9UKG1 DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1 0 9.039 9 3 3 3 709 79.6 5.41 3 3 2397985.219 3 cell proliferation;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;membrane;nucleus protein binding "Pf00169, Pf00640" 26060 ENSG00000157500.10 APPL1 3 Ligand-independent caspase activation via DCC Colorectal cancer; Pathways in cancer; Longevity regulating pathway 0 High Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2 0 4.412 6 2 3 2 385 44.1 6.23 2 1 2 1 3341955.969 4202970.125 2378232 3612243.25 2 2 1 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf04855 6598 ENSG00000099956.18; ENSG00000275837.3 SMARCB1 22; CHR_HSCHR22_1_CTG7 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines 0 High Q9H3K6 BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2 PE=1 SV=1 0 7.869 41 2 3 2 86 10.1 6.52 1 1 1 1 1 1 369058.125 898947.4375 1115513.25 997418.75 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding Pf01722 654483; 552900; 107984053 BOLA2B; BOLA2; LOC107984053 16 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling 0 High Q6P2E9 Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1 0 8.366 3 2 3 2 1401 151.6 5.86 2 1 2 1 1221479.75 477975.125 330104.3438 262445.5625 2 1 1 1 metabolic process cytoplasm;cytosol;membrane;nucleus protein binding Pf00400 23644 ENSG00000038358.14 EDC4 16 mRNA decay by 5' to 3' exoribonuclease RNA degradation 0 High Q8NDN9 RCC1 and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCBTB1 PE=1 SV=1 0 8.87 9 3 3 3 531 58.2 6.47 3 3 3862606.188 3 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding "Pf00415, Pf00651, Pf13540" 55213 ENSG00000136144.11 RCBTB1 13 0 High Q6P3S6 F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1 0 2.566 1 1 3 1 717 77.8 7.43 1 1 1 1 1 1 563331.1875 616204.4375 491503.0625 1 1 1 protein binding "Pf00646, Pf01344, Pf07646, Pf12937, Pf13415, Pf13418, Pf13854, Pf13964" 54455 ENSG00000037637.10 FBXO42 1 0 High O75503 Ceroid-lipofuscinosis neuronal protein 5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2 0 5.003 5 2 3 2 358 41.5 7.4 2 3 615064.625 607975 969726 1272922.75 1 1 1 2 cell differentiation;cellular homeostasis;metabolic process;transport cytosol;endoplasmic reticulum;Golgi;membrane;vacuole protein binding Pf15014 1203 ENSG00000102805.14 CLN5 13 Lysosome 0 High P25787 Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2 0 4.889 17 3 3 3 234 25.9 7.43 3 3 2114033.5 759986.0625 885147.8125 3 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome catalytic activity;protein binding "Pf00227, Pf10584" 5683 ENSG00000256646.7; ENSG00000106588.10 PSMA2 7 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High P56192 "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" 0 2.871 2 2 3 2 900 101.1 6.16 1 1 1 1 1 1 879837.625 980871.9063 1043477.469 1173676 2 2 2 2 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00043, Pf00133, Pf00458, Pf09334, Pf10978, Pf13409, Pf13410, Pf14497" 4141 ENSG00000166986.14 MARS 12 Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Selenocompound metabolism; Aminoacyl-tRNA biosynthesis 0 High Q96EE3 Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3 0.001 2.381 9 2 3 2 360 39.6 8.09 1 1 1 1 1 1 272997.375 270564.5313 343904 1 1 1 cell communication;cell division;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytosol;membrane;nucleus;vacuole protein binding Pf00400 81929 ENSG00000085415.15 SEH1L 18 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins mTOR signaling pathway; RNA transport 0 High Q96IZ7 Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1 0 2.62 3 1 3 1 334 38.7 11.08 1 1 2 1 482918.5313 279482.625 424804.8125 420506.8125 1 1 1 1 metabolic process;response to stimulus;transport cytoplasm;nucleus protein binding 51319 ENSG00000174891.12 RSRC1 3 0 High O60934 Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1 0 4.698 6 3 3 3 754 84.9 6.9 3 3 1932503.938 398088.375 1021743 2 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf00498, Pf00533, Pf08599" 4683 ENSG00000104320.13 NBN 8 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates Homologous recombination 0 High P09496 Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1 0 2.505 7 2 3 2 248 27.1 4.51 1 1 1 1 1 1 753670.125 1070819.313 515015.8438 357894.0938 2 2 1 1 cell division;cell organization and biogenesis;cellular component movement;metabolic process;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity Pf01086 1211 ENSG00000122705.16 CLTA 9 "Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle 0 Medium A0A0B4J1U7 Immunoglobulin heavy variable 6-1 OS=Homo sapiens OX=9606 GN=IGHV6-1 PE=3 SV=1 0.049 1.054 6 1 3 1 121 13.5 9.2 1 1 1 1 1 1 1081212.75 2869663.5 3955209.25 3258088 1 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding 28385 ENSG00000282745.1; ENSG00000211933.2 IGHV6-1 14; CHR_HSCHR14_3_CTG1 0 High Q15029 116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1 0 6.484 3 3 3 3 972 109.4 5 2 1 2 1 1672334.313 2311143.125 2126334.813 1834270.531 3 3 3 3 cell organization and biogenesis;metabolic process;response to stimulus cytosol;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 9343 ENSG00000108883.12 EFTUD2 17 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High A0A075B6S5 Immunoglobulin kappa variable 1-27 OS=Homo sapiens OX=9606 GN=IGKV1-27 PE=3 SV=1 0 2.933 14 1 3 1 117 12.7 8.29 1 1 1 1 1 1 479420.875 644143.5625 663584.0625 512131.5 1 1 1 1 response to stimulus extracellular;membrane "Pf00047, Pf07679, Pf07686, Pf13927" 28935 ENSG00000282666.1; ENSG00000244575.3 IGKV1-27 CHR_HG2290_PATCH; 2 0 High P46821 Microtubule-associated protein 1B OS=Homo sapiens OX=9606 GN=MAP1B PE=1 SV=2 0 7.184 2 3 3 3 2468 270.5 4.81 3 3 479593.7813 1 cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity 4131 ENSG00000131711.14 MAP1B 5 0 High P22695 "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" 0 6.543 9 3 3 3 453 48.4 8.63 1 2 1 2 472749.6484 2 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00675, Pf05193" 7385 ENSG00000140740.10; ENSG00000284493.1 UQCRC2 16; CHR_HG926_PATCH Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 High Q6P3R8 Serine/threonine-protein kinase Nek5 OS=Homo sapiens OX=9606 GN=NEK5 PE=2 SV=1 0 3.882 3 1 3 1 708 81.4 8.87 1 1 1 1 1 1 7960405 7211438 3888542.75 1 1 1 metabolic process;regulation of biological process catalytic activity;metal ion binding;nucleotide binding "Pf00069, Pf07714, Pf14531" 341676 ENSG00000197168.11 NEK5 13 0 High Q9BYS1 Keratin-associated protein 1-5 OS=Homo sapiens OX=9606 GN=KRTAP1-5 PE=1 SV=1 0 16.19 22 1 3 1 174 18 6.74 1 3 2470880.5 1 Met-loss [N-Term] cytosol protein binding 83895 ENSG00000221852.4; ENSG00000261862.2 KRTAP1-5 17; CHR_HSCHR17_4_CTG4 Keratinization 0 Medium Q8N584 Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=2 SV=2 0.041 1.141 1 1 3 1 583 65.8 6.99 1 1 2 1 4322118 6942394.5 3710936.25 3781856.75 1 1 1 1 protein binding Pf10300 125488 ENSG00000168234.12 TTC39C 18 0 High O15047 Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3 0 4.801 2 3 3 3 1707 185.9 5.14 1 2 1 2 75965.3125 1911803.375 2042787.625 1371281.188 1 2 3 2 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;protein binding;RNA binding "Pf00076, Pf00856, Pf11764, Pf14259" 9739 ENSG00000099381.17 SETD1A 16 PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Lysine degradation 0 High Q7L5L3 Lysophospholipase D GDPD3 OS=Homo sapiens OX=9606 GN=GDPD3 PE=2 SV=3 0 2.963 4 2 3 2 318 36.6 7.97 2 3 867934.875 2 metabolic process cytoplasm;endoplasmic reticulum;membrane catalytic activity;metal ion binding "Pf03009, Pf13653" 79153 ENSG00000102886.14 GDPD3 16 Glycerophospholipid catabolism 0 High Q9NV96 Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1 0 4.295 7 2 3 2 361 40.7 8.59 1 2 1 2 148667.6875 265528.875 877061.625 1688212.531 1 1 1 2 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding;transporter activity Pf03381 55754 ENSG00000112697.15 TMEM30A 6 Neutrophil degranulation 0 High P09211 Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2 0 4.55 9 2 3 2 210 23.3 5.64 2 3 2753711.438 2 Met-loss [N-Term] cell communication;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;enzyme regulator activity;protein binding "Pf00043, Pf02798, Pf14497" 2950 ENSG00000084207.15 GSTP1 11 Glutathione conjugation; Neutrophil degranulation; Detoxification of Reactive Oxygen Species Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Pathways in cancer; Prostate cancer; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Platinum drug resistance 0 High P11387 DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2 0 6.059 4 3 3 3 765 90.7 9.31 2 1 2 1 472507.1094 1046310.844 1174245.469 1425866.656 2 2 2 2 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf01028, Pf02919, Pf14370" 7150 ENSG00000198900.5 TOP1 20 SUMOylation of DNA replication proteins 0 High P04181 "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" 0 7.757 8 3 3 3 439 48.5 7.03 1 2 1 2 237773.3906 929887.0313 2037766.938 1232568.563 1 2 3 2 cell organization and biogenesis;metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;protein binding Pf00202 4942 ENSG00000065154.11 OAT 10 Amino acid synthesis and interconversion (transamination) Metabolic pathways; Arginine and proline metabolism 0 High Q96CS3 FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2 0 5.318 9 2 3 2 445 52.6 5.62 2 3 260159.875 256701.2813 1406081.25 1187289.031 2 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;organelle lumen enzyme regulator activity;protein binding "Pf00789, Pf14555" 23197 ENSG00000113194.12 FAF2 5 Neutrophil degranulation 0 High P43307 Translocon-associated protein subunit alpha OS=Homo sapiens OX=9606 GN=SSR1 PE=1 SV=3 0.006 1.808 3 1 3 1 286 32.2 4.49 1 1 2 1 154990.5469 1344673.375 2392965.5 2580466.5 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;membrane protein binding Pf03896 6745 ENSG00000124783.12 SSR1 6 XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein processing in endoplasmic reticulum 0 High Q96AE7 Tetratricopeptide repeat protein 17 OS=Homo sapiens OX=9606 GN=TTC17 PE=1 SV=1 0 5.696 4 3 3 3 1141 129.5 6.58 2 1 2 1 1232998.25 913429.1094 3 2 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00515, Pf02841, Pf13414, Pf13424, Pf13432" 55761 ENSG00000052841.14 TTC17 11 0 High P21108 Ribose-phosphate pyrophosphokinase 3 OS=Homo sapiens OX=9606 GN=PRPS1L1 PE=1 SV=2 0 3.208 16 2 3 1 318 34.8 6.35 1 1 1 1 1 1 metabolic process catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00156, Pf13793, Pf14572" 221823 ENSG00000229937.6 PRPS1L1 7 5-Phosphoribose 1-diphosphate biosynthesis Carbon metabolism; Purine metabolism; Pentose phosphate pathway; Biosynthesis of amino acids; Metabolic pathways 0 Medium Q9Y2A7 Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1 0.032 1.243 1 1 3 1 1128 128.7 6.62 1 1 1 1 1 1 332702 5199179.5 6473661.5 6440672.5 1 1 1 1 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus cytosol;membrane protein binding Pf09735 10787 ENSG00000061676.14 NCKAP1 2 Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs Regulation of actin cytoskeleton 0 High P25789 Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1 0 5.629 5 2 3 2 261 29.5 7.72 1 1 1 1 1 1 252339.7344 1449056.188 1270719.938 1092237.75 1 2 2 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding "Pf00227, Pf10584" 5685 ENSG00000041357.15 PSMA4 15 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 High P23284 Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2 0 2.822 6 1 3 1 216 23.7 9.41 1 1 1 1 1 1 858282.8125 862332.9375 718555.625 1302639 1 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane;nucleus;organelle lumen catalytic activity;protein binding;RNA binding Pf00160 5479 ENSG00000166794.4 PPIB 15 Collagen biosynthesis and modifying enzymes 0 High Q86VP6 Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2 0 3.861 2 2 3 2 1230 136.3 5.78 2 1 2 1 292511.7188 609133.4531 1307552.25 275323.875 1 2 2 1 Met-loss+Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen protein binding "Pf08623, Pf12755, Pf13513" 55832 ENSG00000111530.12 CAND1 12 Neutrophil degranulation; Iron uptake and transport; Neddylation 0 High P33176 Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1 0 7.068 4 3 3 3 963 109.6 6.51 3 3 2550273.719 885016.0313 657975.875 3 2 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf01576, Pf02463, Pf03999, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf07111, Pf07888, Pf10174, Pf12128, Pf13514, Pf13851, Pf14915" 3799 ENSG00000170759.10 KIF5B 10 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; Insulin processing; MHC class II antigen presentation Dopaminergic synapse; Endocytosis 0 High Q8NDZ4 Divergent protein kinase domain 2A OS=Homo sapiens OX=9606 GN=DIPK2A PE=1 SV=1 0 4.024 6 2 3 2 430 49.5 8.53 2 3 135715.9219 1218120.125 1 2 cell proliferation;regulation of biological process extracellular;Golgi;membrane Pf12260 205428 ENSG00000181744.8 C3orf58 3 0 Low O14529 Homeobox protein cut-like 2 OS=Homo sapiens OX=9606 GN=CUX2 PE=1 SV=4 0.052 0.997 1 1 3 1 1486 161.6 5.48 1 1 2 1 3857251 563081.1875 1 1 development;metabolic process;regulation of biological process;response to stimulus;transport membrane;nucleus catalytic activity;DNA binding;motor activity "Pf00046, Pf00261, Pf01576, Pf02376, Pf05622, Pf07851, Pf10267, Pf15397" 23316 ENSG00000111249.13 CUX2 12 0 Medium Q9UKN7 Unconventional myosin-XV OS=Homo sapiens OX=9606 GN=MYO15A PE=1 SV=2 0.047 1.068 0 1 3 1 3530 395 9.17 1 1 1 2 6606554.5 14699600 12690781 9238273 1 1 1 1 response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00373, Pf00784, Pf07653, Pf15279" 51168 ENSG00000091536.16 MYO15A 17 0 High Q9UPS8 Ankyrin repeat domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ANKRD26 PE=1 SV=4 0 6.596 2 3 3 3 1710 196.3 5.72 3 3 180504.4375 1107640.375 1282162.844 1288496.5 1 3 3 3 0 High Q53H12 "Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2" 0 3.188 5 2 3 2 422 47.1 8.09 2 3 611300.5781 333273.8125 971455.1563 1351226.813 2 2 2 2 cell organization and biogenesis;metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding Pf00781 55750 ENSG00000006530.15 AGK 7 Signaling by BRAF and RAF fusions; Glycerophospholipid biosynthesis Glycerolipid metabolism; Metabolic pathways 0 High Q05048 Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1 0 5.575 6 2 2 2 431 48.3 6.58 2 2 952434.2188 167187.4063 175296.4531 2 1 1 metabolic process nucleus protein binding;RNA binding "Pf00400, Pf11768" 1477 ENSG00000101138.11 CSTF1 20 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High O95071 E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2 0.001 2.228 1 1 2 1 2799 309.2 5.85 1 2 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00632, Pf00658, Pf02207, Pf11547" 51366 ENSG00000104517.12 UBR5 8 Ubiquitin mediated proteolysis 0 High Q96PU8 Protein quaking OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1 0.007 1.717 2 1 2 1 341 37.6 8.56 1 1 1 1 648241.4375 904367.75 884614.5 1361497 1 1 1 1 cell differentiation;development;metabolic process;regulation of biological process;transport cytoplasm;nucleus protein binding;RNA binding "Pf00013, Pf13014" 9444 ENSG00000112531.16 QKI 6 Signaling by BRAF and RAF fusions 0 High Q92560 Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2 0 5.747 3 2 2 2 729 80.3 6.84 1 1 1 1 252900.2344 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf01088 8314 ENSG00000163930.9 BAP1 3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; UCH proteinases 0 High Q92598 Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1 0 5.416 3 2 2 2 858 96.8 5.39 1 1 1 1 1218990.25 1915028.75 507309.0938 1 2 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen enzyme regulator activity;nucleotide binding;protein binding Pf00012 10808 ENSG00000120694.19 HSPH1 13 Scavenging by Class F Receptors; Regulation of HSF1-mediated heat shock response Protein processing in endoplasmic reticulum 0 High Q96IX5 "ATP synthase membrane subunit DAPIT, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MD PE=1 SV=1" 0 6.137 29 2 2 2 58 6.5 9.76 2 2 651042.625 3518340.125 1 2 Met-loss [N-Term] membrane;mitochondrion Pf14960 84833 ENSG00000173915.14 USMG5 10 0 High Q9UNY4 Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2 0 4.079 2 2 2 2 1162 129.5 8.37 2 2 754978.5938 6164728 916285.7734 2 1 2 metabolic process;regulation of biological process cytoplasm;cytosol;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00176, Pf00271, Pf06839" 8458 ENSG00000116830.11 TTF2 1 Thyroid hormone synthesis 0 High Q9UH99 SUN domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUN2 PE=1 SV=3 0 5.981 4 2 2 2 717 80.3 6.73 2 2 352815.25 509494.0625 313963.0625 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;transport chromosome;endosome;membrane;nucleus protein binding Pf07738 25777 ENSG00000100242.15 SUN2 22 Meiotic synapsis 0 High Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1 0 2.581 1 1 2 1 1792 201.4 9.64 1 1 1 1 318783.6563 419217.6563 382280.8438 273002.4375 1 1 1 1 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00098, Pf08783, Pf10243, Pf13639, Pf13696, Pf13920, Pf13923, Pf14634, Pf15227" 5930 ENSG00000122257.18 RBBP6 16 Antigen processing: Ubiquitination & Proteasome degradation 0 High Q8N766 ER membrane protein complex subunit 1 OS=Homo sapiens OX=9606 GN=EMC1 PE=1 SV=1 0 3.501 2 2 2 2 993 111.7 7.66 2 2 155032.375 1016210.25 1 2 metabolic process endoplasmic reticulum;membrane "Pf07774, Pf13360" 23065 ENSG00000127463.13 EMC1 1 0 High Q3SY77 UDP-glucuronosyltransferase 3A2 OS=Homo sapiens OX=9606 GN=UGT3A2 PE=2 SV=1 0.006 1.894 2 1 2 1 523 59.5 8.31 1 2 795059 1 metabolic process;response to stimulus membrane catalytic activity Pf00201 167127 ENSG00000168671.9 UGT3A2 5 Glucuronidation 0 Medium Q4VXA5 KH homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KHDC1 PE=2 SV=1 0.048 1.067 3 1 2 1 237 27.1 8.29 1 2 1644893.5 1 membrane RNA binding 80759 ENSG00000135314.12 KHDC1 6 0 High P35580 Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3 0 4.167 1 2 2 1 1976 228.9 5.54 1 1 1 1 248177.7813 213887.4063 242644.4688 1 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytosol;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf00063, Pf00769, Pf01496, Pf01576, Pf02736, Pf04111, Pf05622, Pf05911, Pf06637, Pf07888, Pf09726, Pf12128, Pf13094, Pf13514" 4628 ENSG00000133026.12 MYH10 17 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Salmonella infection; Regulation of actin cytoskeleton 0 High Q96BY9 Store-operated calcium entry-associated regulatory factor OS=Homo sapiens OX=9606 GN=SARAF PE=1 SV=1 0.006 1.808 2 1 2 1 339 37 7.58 1 1 1 1 369110.1875 290121.8125 1 1 regulation of biological process;transport endoplasmic reticulum;membrane protein binding Pf06682 51669 ENSG00000133872.13 TMEM66; SARAF 8 0 High Q53GT1 Kelch-like protein 22 OS=Homo sapiens OX=9606 GN=KLHL22 PE=1 SV=2 0 3.504 4 2 2 2 634 71.6 5.49 1 1 1 1 331472.8125 343238.7813 321636.8125 469501.5313 1 1 1 1 Met-loss+Acetyl [N-Term] cell division;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964" 84861 ENSG00000099910.16 KLHL22 22 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High P34897 "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" 0 6.466 7 2 2 1 504 56 8.53 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00464 6472 ENSG00000182199.10 SHMT2 12 Metabolism of folate and pterines "Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism" 0 High Q9BTT4 Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1 0.006 1.849 7 1 2 1 135 15.7 6.19 1 1 1 1 426369.5625 509418.625 338364.7813 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf09748 84246 ENSG00000133398.3 MED10 5 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 High Q99996 A-kinase anchor protein 9 OS=Homo sapiens OX=9606 GN=AKAP9 PE=1 SV=4 0 4.233 1 2 2 2 3907 452.7 4.98 2 2 559762.7188 124068.1328 79235.17188 2 1 1 0 High P04792 Heat shock protein beta-1 OS=Homo sapiens OX=9606 GN=HSPB1 PE=1 SV=2 0 6.436 13 2 2 2 205 22.8 6.4 1 1 1 1 461293.7813 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus;proteasome enzyme regulator activity;protein binding;RNA binding Pf00011 3315 ENSG00000106211.8 HSPB1 7 AUF1 (hnRNP D0) binds and destabilizes mRNA; VEGFA-VEGFR2 Pathway; MAPK6/MAPK4 signaling Amoebiasis; Epstein-Barr virus infection; VEGF signaling pathway; MAPK signaling pathway 0 High P07996 Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2 0 5.184 2 2 2 2 1170 129.3 4.94 2 2 439519.9688 637603.6875 335693.2813 1 1 1 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;extracellular;organelle lumen metal ion binding;protein binding "Pf00090, Pf00093, Pf02412, Pf05735, Pf12947" 7057 ENSG00000137801.10 THBS1 15 Platelet degranulation ; Integrin cell surface interactions; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Defective B3GALTL causes Peters-plus syndrome (PpS); O-glycosylation of TSR domain-containing proteins; Signaling by PDGF; Syndecan interactions TGF-beta signaling pathway; MicroRNAs in cancer; Rap1 signaling pathway; Phagosome; Focal adhesion; Malaria; Proteoglycans in cancer; p53 signaling pathway; Bladder cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q9H329 Band 4.1-like protein 4B OS=Homo sapiens OX=9606 GN=EPB41L4B PE=2 SV=2 0 5.181 2 2 2 1 900 99.7 9.04 2 2 213510.6563 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 54566 ENSG00000095203.14 EPB41L4B 9 0 High Q9H6R7 WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1 0 4.385 4 2 2 2 721 79.1 6.7 2 2 1289835.094 2 cell organization and biogenesis protein binding Pf15390 80304 ENSG00000163026.11 C2orf44; WDCP 2 0 High Q8NBL1 Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1 0 3.201 3 1 2 1 392 46.2 8.72 1 2 208374.9531 1357235.5 1 1 development;metabolic process;regulation of biological process endoplasmic reticulum;organelle lumen catalytic activity Pf05686 56983 ENSG00000163389.10 POGLUT1 3 Pre-NOTCH Processing in the Endoplasmic Reticulum Other types of O-glycan biosynthesis 0 High Q9H0U3 Magnesium transporter protein 1 OS=Homo sapiens OX=9606 GN=MAGT1 PE=1 SV=1 0 2.899 6 2 2 2 335 38 9.63 2 2 80561.74219 234952.8281 437072.9063 9783252.25 1 1 1 2 metabolic process;transport endoplasmic reticulum;membrane catalytic activity;transporter activity Pf04756 84061 ENSG00000102158.19 MAGT1 X Asparagine N-linked glycosylation; Neutrophil degranulation; Miscellaneous transport and binding events 0 High O43657 Tetraspanin-6 OS=Homo sapiens OX=9606 GN=TSPAN6 PE=1 SV=1 0 4.15 16 2 2 2 245 27.5 8.1 2 2 1087572.781 2 regulation of biological process;response to stimulus membrane protein binding;signal transducer activity Pf00335 7105 ENSG00000000003.14 TSPAN6 X 0 Medium Q6IAN0 Dehydrogenase/reductase SDR family member 7B OS=Homo sapiens OX=9606 GN=DHRS7B PE=1 SV=2 0.013 1.502 2 1 2 1 325 35.1 9.55 1 1 1 1 101536.8594 265476.3125 157066.0781 1 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00106, Pf08659, Pf13460, Pf13561" 25979 ENSG00000109016.17 DHRS7B 17 0 High Q6P161 "39S ribosomal protein L54, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" 0.007 1.718 7 1 2 1 138 15.8 9.6 1 1 1 1 533959.0625 580476.625 363184.6875 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding Pf08561 116541 ENSG00000183617.4 MRPL54 19 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High Q9H9Y6 DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2 0 2.807 1 1 2 1 1135 128.1 7.83 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04567, Pf06883" 84172 ENSG00000125630.15 POLR1B 2 RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation Purine metabolism; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High P04062 Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA PE=1 SV=3 0.001 2.395 2 1 2 1 536 59.7 7.61 1 2 495538.125 1438086.125 1 1 cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;organelle lumen;vacuole catalytic activity;protein binding Pf02055 2629 ENSG00000177628.15 GBA 1 Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis Lysosome; Sphingolipid metabolism; Other glycan degradation; Metabolic pathways 0 High Q9Y490 Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3 0 2.519 2 2 2 2 2541 269.6 6.07 2 2 169246.2813 310899.4453 1 2 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytoskeleton;cytosol;extracellular;membrane protein binding;structural molecule activity "Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379" 7094 ENSG00000137076.20 TLN1 9 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; XBP1(S) activates chaperone genes; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling Rap1 signaling pathway; HTLV-I infection; Focal adhesion; Platelet activation 0 High Q13217 DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1 0 3.985 4 2 2 2 504 57.5 6.15 2 2 246342.8438 239994.1406 554142.375 1 1 2 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;organelle lumen enzyme regulator activity;protein binding "Pf00226, Pf00515, Pf12569, Pf13371, Pf13414, Pf13432, Pf14559" 5611 ENSG00000102580.14 DNAJC3 13 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Viral mRNA Translation; Neutrophil degranulation; XBP1(S) activates chaperone genes Protein processing in endoplasmic reticulum; Influenza A 0 High P09543 "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" 0 5.69 6 2 2 2 421 47.5 9.07 1 1 1 1 94039.97656 200462.4688 318894.9688 415563.125 1 1 1 1 cell communication;cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;membrane catalytic activity;nucleotide binding;RNA binding "Pf01591, Pf05881, Pf08302, Pf13207, Pf13671" 1267 ENSG00000173786.16 CNP 17 0 Medium Q16659 Mitogen-activated protein kinase 6 OS=Homo sapiens OX=9606 GN=MAPK6 PE=1 SV=1 0.015 1.416 1 1 2 1 721 82.6 5.03 1 1 1 1 171949.0156 247021.2344 261510.7188 469615 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf01636, Pf07714, Pf14531" 5597 ENSG00000069956.11 MAPK6 15 MAPK6/MAPK4 signaling 0 Medium Q13075 Baculoviral IAP repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=NAIP PE=1 SV=3 0.042 1.124 0 1 2 1 1403 159.5 5.99 1 1 1 1 255733.7656 300775.2813 502136.9063 437888.0313 1 1 1 1 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00653, Pf05729, Pf13401" 4671 ENSG00000249437.7 NAIP 5 NOD-like receptor signaling pathway; Legionellosis 0 High Q9HCN8 Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2 0 4.511 6 1 2 1 221 23.6 7.03 1 2 416171.5625 258281.9531 1126597.25 1 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding Pf02815 23753 ENSG00000128228.4 SDF2L1 22 0 High P18887 DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=2 0 3.992 3 2 2 2 633 69.4 6.39 2 2 1199409.313 347746.4297 176175.6406 2 2 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding "Pf00533, Pf01834, Pf12738" 7515 XRCC1 19 Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER Base excision repair 0 High Q5MNZ6 WD repeat domain phosphoinositide-interacting protein 3 OS=Homo sapiens OX=9606 GN=WDR45B PE=1 SV=2 0 3.224 6 2 2 2 344 38.1 7.59 1 1 1 1 119591.1016 218889.3906 180423.4688 177476.3125 1 1 1 1 metabolic process cytosol;membrane protein binding 56270 ENSG00000141580.15 WDR45B; WDR45L 17 Macroautophagy 0 High Q6P1M0 Long-chain fatty acid transport protein 4 OS=Homo sapiens OX=9606 GN=SLC27A4 PE=1 SV=1 0 3.369 3 2 2 2 643 72 8.47 2 2 110405.375 304084.3438 799179.4688 1 1 2 metabolic process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;transporter activity "Pf00501, Pf13193" 10999 ENSG00000167114.12 SLC27A4 9 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS); Transport of fatty acids Fat digestion and absorption; PPAR signaling pathway; Insulin resistance 0 High O43615 Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2 0 7.028 6 2 2 2 452 51.3 8.32 1 1 1 1 459838.5938 512455.0625 546768.8125 1167772.625 1 1 1 2 transport membrane;mitochondrion;organelle lumen nucleotide binding;protein binding "Pf04280, Pf07091" 10469 ENSG00000104980.7 TIMM44 19 Mitochondrial protein import; Metabolism of proteins 0 High Q5JPE7 Nodal modulator 2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1 0 4.336 1 2 2 2 1267 139.4 5.76 2 2 182191.332 997165.6563 2 2 regulation of biological process endoplasmic reticulum;membrane protein binding "Pf09430, Pf13620, Pf13715, Pf14686" 283820 ENSG00000185164.14 NOMO2 16 0 High O00139 Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3 0 3.812 3 2 2 2 706 79.9 6.68 2 2 474588.7188 445263.8281 584344.4063 285652.9375 2 2 2 1 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;development;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding Pf00225 3796 ENSG00000068796.16 KIF2A 5 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation 0 High Q9Y2W1 Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2 0 3.172 2 2 2 2 955 108.6 10.15 2 2 314089.1563 896594.5625 798697.0625 536533.4219 1 2 2 2 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;nucleotide binding;protein binding;receptor activity;RNA binding Pf15440 9967 ENSG00000054118.13 THRAP3 1 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High O94788 Retinal dehydrogenase 2 OS=Homo sapiens OX=9606 GN=ALDH1A2 PE=1 SV=3 0 3.301 3 2 2 1 518 56.7 6.05 1 1 1 1 135481.6563 232446.9688 345191.6563 332943.375 1 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity "Pf00171, Pf05893" 8854 ENSG00000128918.14 ALDH1A2 15 RA biosynthesis pathway Retinol metabolism; Metabolic pathways 0 Medium P61927 60S ribosomal protein L37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2 0.018 1.378 10 1 2 1 97 11.1 11.74 1 1 1 1 2091048.75 2741114.5 4650872.5 1243452.5 1 1 1 1 Met-loss [N-Term] cell organization and biogenesis;metabolic process;transport cytosol;ribosome metal ion binding;RNA binding;structural molecule activity Pf01907 6167 ENSG00000145592.13 RPL37 5 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8N4V1 Membrane magnesium transporter 1 OS=Homo sapiens OX=9606 GN=MMGT1 PE=1 SV=1 0 4.833 18 1 2 1 131 14.7 9.16 1 1 1 1 260719.1875 803061.6875 840769.625 788430.6875 1 1 1 1 transport endoplasmic reticulum;endosome;Golgi;membrane transporter activity Pf10270 93380 ENSG00000169446.5 MMGT1 X Miscellaneous transport and binding events 0 High P15586 N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3 0 3.586 3 2 2 2 552 62 8.31 2 2 405700.1719 1721358.75 2 2 metabolic process;transport extracellular;organelle lumen;vacuole catalytic activity;metal ion binding;protein binding "Pf00884, Pf01663" 2799 ENSG00000135677.10 GNS 12 Neutrophil degranulation; MPS IIID - Sanfilippo syndrome D; Keratan sulfate degradation; Lysosome Vesicle Biogenesis Lysosome; Glycosaminoglycan degradation; Metabolic pathways 0 High Q6UW63 Protein O-glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POGLUT2 PE=1 SV=1 0 3.824 4 2 2 2 502 58 7.71 2 2 73273.91406 590588.5469 1 2 metabolic process endoplasmic reticulum;organelle lumen catalytic activity;protein binding "Pf00630, Pf05686, Pf13524" 79070 ENSG00000134901.12 KDELC1 13 0 High Q9H4F1 "Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase OS=Homo sapiens OX=9606 GN=ST6GALNAC4 PE=2 SV=2" 0 3.388 6 2 2 2 302 34.2 8.57 2 2 99273.59375 1930912.188 1 2 metabolic process Golgi;membrane catalytic activity Pf00777 27090 ENSG00000136840.18 ST6GALNAC4 9 Termination of O-glycan biosynthesis; Sialic acid metabolism Glycosphingolipid biosynthesis - ganglio series; Metabolic pathways 0 High Q9HC07 Transmembrane protein 165 OS=Homo sapiens OX=9606 GN=TMEM165 PE=1 SV=1 0 4.099 8 1 2 1 324 34.9 7.02 1 2 128039.3828 214979.5625 223798.625 680299.0625 1 1 1 1 cellular homeostasis;metabolic process;transport endosome;Golgi;membrane;vacuole Pf01169 55858 ENSG00000134851.12 TMEM165 4 0 High Q9Y4C2 TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3 0 3.156 2 2 2 2 921 102.1 6.54 1 1 1 1 401007.5625 575392.7656 389948.9766 471400.8906 2 2 2 2 regulation of biological process;transport membrane protein binding Pf13402 9747 ENSG00000198420.9 FAM115A; TCAF1 7 0 High O75534 Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2 0.003 2.118 1 1 2 1 798 88.8 6.25 1 1 1 1 256154.6406 266470.25 388250 237587.6875 1 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;membrane DNA binding;protein binding;RNA binding "Pf00313, Pf12901" 7812 ENSG00000009307.15 CSDE1 1 0 High Q07955 Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2 0 4.022 5 1 2 1 248 27.7 10.36 1 1 1 1 756125.1875 887765.6875 1124176.5 680019.5 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 6426 ENSG00000136450.12 SRSF1 17 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome; Herpes simplex infection 0 High Q9BZF3 Oxysterol-binding protein-related protein 6 OS=Homo sapiens OX=9606 GN=OSBPL6 PE=1 SV=1 0 3.668 3 2 2 2 934 106.2 6.93 2 2 metabolic process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus protein binding;transporter activity "Pf00169, Pf01237, Pf15409" 114880 ENSG00000079156.16 OSBPL6 2 Synthesis of bile acids and bile salts 0 High P63220 40S ribosomal protein S21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1 0 7.289 22 1 2 1 83 9.1 8.5 1 1 1 1 301955.125 518609.5625 1 1 cell organization and biogenesis;metabolic process;transport cytosol;ribosome protein binding;RNA binding;structural molecule activity Pf01249 6227 ENSG00000171858.17 RPS21 20 "Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane" Ribosome 0 High P09382 Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2 0 4.573 15 2 2 2 135 14.7 5.5 2 2 1115000.5 2 cell death;cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;nucleus;organelle lumen protein binding;RNA binding;signal transducer activity Pf00337 3956 ENSG00000100097.11 LGALS1 22 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0 High P62891 60S ribosomal protein L39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2 0.001 2.366 20 1 2 1 51 6.4 12.56 1 1 1 1 1830026.625 3332759.75 2922266.5 1463707.625 1 1 1 1 cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport cytosol;ribosome RNA binding;structural molecule activity Pf00832 6170; 285785 ENSG00000198918.7 RPL39; RPL39P3 X; 6 Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 Medium Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo sapiens OX=9606 GN=ITIH3 PE=1 SV=2 0.02 1.354 2 1 2 1 890 99.8 5.74 1 1 1 1 262648.0313 239552.7188 1 1 metabolic process;regulation of biological process;transport extracellular;organelle lumen enzyme regulator activity "Pf00092, Pf06668, Pf08487, Pf11443, Pf13519, Pf13768" 3699 ENSG00000162267.12 ITIH3 3 Platelet degranulation 0 High Q9P0L0 Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3 0 2.538 6 1 2 1 249 27.9 8.62 1 1 1 1 163517.7656 216886.0156 377724.9375 216824 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoskeleton;endoplasmic reticulum;membrane;nucleus protein binding;signal transducer activity Pf00635 9218 ENSG00000101558.13 VAPA 18 Neutrophil degranulation; Sphingolipid de novo biosynthesis Tight junction 0 High A0A286YF46 Small cysteine and glycine repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=SCYGR5 PE=1 SV=1 0 11.127 33 2 2 2 85 8.2 7.94 2 2 1496815.125 1 0 High Q96G23 Ceramide synthase 2 OS=Homo sapiens OX=9606 GN=CERS2 PE=1 SV=1 0 5.794 4 1 2 1 380 44.8 8.98 1 1 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane;nucleus catalytic activity;DNA binding;protein binding Pf03798 29956 ENSG00000143418.19 CERS2 1 Sphingolipid de novo biosynthesis Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways 0 High Q5VTL8 Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1 0.01 1.615 1 1 2 1 546 64.4 10.54 1 1 1 1 603246.4375 404092.375 587384.625 741852.3125 1 1 1 1 metabolic process nucleus;spliceosomal complex RNA binding Pf03371 55119 ENSG00000134186.11 PRPF38B 1 Spliceosome 0 High P17050 Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2 0 3.787 3 1 2 1 411 46.5 5.19 1 2 270730.125 3473320.75 1 1 metabolic process cytoplasm;vacuole catalytic activity;protein binding Pf02065 4668 ENSG00000198951.11 NAGA 22 Lysosome; Glycosphingolipid biosynthesis - globo and isoglobo series 0 High O14980 Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1 0 5.314 2 2 2 2 1071 123.3 6.06 2 2 318901.1563 430516.8828 609306.3438 1042196.625 1 2 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;transporter activity "Pf03810, Pf08389, Pf08767" 7514 ENSG00000082898.16 XPO1 2 Rev-mediated nuclear export of HIV RNA; Downregulation of TGF-beta receptor signaling; NEP/NS2 Interacts with the Cellular Export Machinery; Cyclin A/B1/B2 associated events during G2/M transition; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deactivation of the beta-catenin transactivating complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HuR (ELAVL1) binds and stabilizes mRNA; RHO GTPases Activate Formins; MAPK6/MAPK4 signaling Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; HTLV-I infection; RNA transport; Influenza A 0 High O60244 Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2 0 2.52 1 1 2 1 1454 160.5 8.73 1 1 1 1 392960.5625 359528.6563 468312.4063 456020.4375 1 1 1 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity "Pf08638, Pf15449" 9282 ENSG00000180182.10 MED14 X Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High O14744 Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4 0 3.332 4 2 2 2 637 72.6 6.29 2 2 287212.3125 220050.1094 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf02475, Pf05185" 10419 ENSG00000100462.15 PRMT5 14 snRNP Assembly; Regulation of TP53 Activity through Methylation; RMTs methylate histone arginines RNA transport 0 High Q14161 ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2 0 3.11 2 2 2 2 759 84.5 7.23 2 2 358913.7109 188858.0938 122369.8125 2 1 1 regulation of biological process enzyme regulator activity;metal ion binding;protein binding "Pf00023, Pf01412, Pf07558, Pf08518, Pf12205, Pf12796, Pf13637, Pf13857" 9815 ENSG00000139436.20 GIT2 12 Endocytosis 0 Medium Q9NX70 Mediator of RNA polymerase II transcription subunit 29 OS=Homo sapiens OX=9606 GN=MED29 PE=1 SV=1 0.011 1.523 4 1 2 1 200 21.1 6.29 1 1 1 1 265244.125 285279.625 337526.875 1 1 1 metabolic process;regulation of biological process nucleus protein binding Pf11568 55588 ENSG00000063322.13 MED29 19 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q9HA77 "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" 0 6.972 5 2 2 2 564 62.2 8.34 1 1 1 1 837833.1875 1658196.125 1507529.813 2 2 2 metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding "Pf00133, Pf01406, Pf01921, Pf09334" 79587 ENSG00000134905.16 CARS2 13 Mitochondrial tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High P47897 Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1 0 3.217 2 1 2 1 775 87.7 7.15 1 2 126580.9922 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;organelle lumen catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00749, Pf03950, Pf04557, Pf04558" 5859 ENSG00000172053.17 QARS 3 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins Aminoacyl-tRNA biosynthesis; Metabolic pathways 0 High P49792 E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2 0 3.495 1 2 2 2 3224 358 6.2 1 1 1 1 722988.8125 769948.5313 984285.3438 685244.3125 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;metal ion binding;protein binding;RNA binding "Pf00160, Pf00515, Pf00638, Pf00641, Pf07719, Pf12185, Pf13414, Pf13432, Pf14559" 5903 ENSG00000153201.15 RANBP2 2 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q4KWH8 "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" 0.007 1.733 0 1 2 1 1693 189.1 7.74 1 1 1 1 2127115.25 21099508 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;protein binding;signal transducer activity "Pf00036, Pf00168, Pf00387, Pf00388, Pf09279, Pf13499, Pf14788" 23007 ENSG00000114805.16 PLCH1 3 Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism; Metabolic pathways 0 High Q12891 Hyaluronidase-2 OS=Homo sapiens OX=9606 GN=HYAL2 PE=1 SV=4 0 2.511 4 1 2 1 473 53.8 8.19 1 2 1029118.625 1573177.25 1 1 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole catalytic activity;enzyme regulator activity;protein binding;receptor activity Pf01630 8692 ENSG00000068001.13 HYAL2 3 Hyaluronan uptake and degradation Glycosaminoglycan degradation; Metabolic pathways 0 Medium Q14684 Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3 0.047 1.077 1 1 2 1 758 84.4 9.76 1 1 1 1 190038.2188 346582.8125 328317.5625 1 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus protein binding;RNA binding Pf05997 23076 ENSG00000160208.12 RRP1B 21 0 High O75822 Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2 0 3.249 8 2 2 2 258 29 4.83 2 2 536024.3281 599128.2188 679508.375 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol protein binding;RNA binding Pf08597 8669 ENSG00000104131.12 EIF3J 15 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High P55036 26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1 0 2.729 11 2 2 2 377 40.7 4.79 1 1 1 1 2054982400 2586077184 2698547200 1611052160 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf02809, Pf04056, Pf13519" 5710 ENSG00000159352.15 PSMD4 1 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 High Q9H204 Mediator of RNA polymerase II transcription subunit 28 OS=Homo sapiens OX=9606 GN=MED28 PE=1 SV=1 0.007 1.733 5 1 2 1 178 19.5 5.58 1 1 1 1 225677.8906 259146.0313 312557.5625 351070.0313 1 1 1 1 metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus protein binding Pf11594 80306 ENSG00000118579.12 MED28 4 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q9NX63 MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1 0 3.02 9 2 2 2 227 26.1 8.28 2 2 2067102.328 1950306.438 1462778.125 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;nucleus protein binding;structural molecule activity "Pf05300, Pf06747" 54927 ENSG00000106554.11 CHCHD3 7 Cristae formation; Mitochondrial protein import; Metabolism of proteins 0 High Q9P2K8 eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3 0 4.154 2 2 2 2 1649 186.8 6.28 2 2 555207.1719 2 cell communication;cell growth;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00069, Pf00587, Pf05773, Pf07714, Pf12745" 440275 ENSG00000128829.11 EIF2AK4 15 Epstein-Barr virus infection; Protein processing in endoplasmic reticulum; Measles; Herpes simplex infection; Hepatitis C; Influenza A 0 Medium Q9HD45 Transmembrane 9 superfamily member 3 OS=Homo sapiens OX=9606 GN=TM9SF3 PE=1 SV=2 0.028 1.303 1 1 2 1 589 67.8 7.21 1 1 1 1 192961.6719 670548.3125 703401.0625 1 1 1 membrane Pf02990 56889 ENSG00000077147.14 TM9SF3 10 0 Low P11177 "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" 0.055 0.975 4 1 2 1 359 39.2 6.65 1 1 1 1 3477952.75 7720900 7362637 5295101.5 1 1 1 1 metabolic process;regulation of biological process mitochondrion;nucleus;organelle lumen catalytic activity;protein binding "Pf02779, Pf02780" 5162 ENSG00000168291.12 PDHB 3 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High O00469 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens OX=9606 GN=PLOD2 PE=1 SV=2" 0 6.402 4 2 2 2 737 84.6 6.71 2 2 194537.6563 798512.1875 217414.9375 1 1 1 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf03171 5352 ENSG00000152952.11 PLOD2 3 Collagen biosynthesis and modifying enzymes Lysine degradation 0 High O94813 Slit homolog 2 protein OS=Homo sapiens OX=9606 GN=SLIT2 PE=1 SV=1 0 2.865 1 2 2 2 1529 169.8 7.06 2 2 1174450.219 2 cell death;cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular;membrane enzyme regulator activity;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00008, Pf00054, Pf01462, Pf02210, Pf12799, Pf13306, Pf13855, Pf14580" 9353 ENSG00000145147.19 SLIT2 4 Netrin-1 signaling; SLIT2:ROBO1 increases RHOA activity; Activation of RAC1; Regulation of expression of SLITs and ROBOs; Regulation of commissural axon pathfinding by SLIT and ROBO; Inactivation of CDC42 and RAC1; Role of ABL in ROBO-SLIT signaling Axon guidance 0 High Q6PEX3 Keratin-associated protein 26-1 OS=Homo sapiens OX=9606 GN=KRTAP26-1 PE=1 SV=1 0 7.017 8 1 2 1 210 22.5 7.71 1 2 3120040.375 2 Met-loss+Acetyl [N-Term] cytosol protein binding Pf05287 388818 ENSG00000197683.4 KRTAP26-1 21 Keratinization 0 Medium O75190 DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2 0.011 1.559 2 1 2 1 326 36.1 9.16 1 1 1 1 98820.70313 181530.6719 391698.9688 652171.4375 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;enzyme regulator activity;protein binding Pf00226 10049 ENSG00000105993.14 DNAJB6 7 Regulation of HSF1-mediated heat shock response 0 High O14950 Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2 0 5.693 12 2 2 2 172 19.8 4.84 1 1 1 1 263225.1563 561832.875 427935.2188 1 1 1 regulation of biological process;response to stimulus cytosol metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13833" 103910; 10627 ENSG00000118680.12 MYL12B; MYL12A 18 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Focal adhesion; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Platelet activation 0 High Q9Y5V3 Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3 0.004 2.028 2 2 2 2 778 86.1 5.83 2 2 249107.3125 676274.5 492776.6875 1183132.125 1 2 1 2 regulation of biological process chromosome;cytoplasm;membrane;nucleus protein binding "Pf00874, Pf01454" 9500 ENSG00000179222.17 MAGED1 X Ligand-independent caspase activation via DCC; NRAGE signals death through JNK; Signalling by NGF Neurotrophin signaling pathway 0 High Q32MH5 Protein FAM214A OS=Homo sapiens OX=9606 GN=FAM214A PE=1 SV=2 0 3.308 3 2 2 2 1076 121.6 7.9 2 2 759177.875 861229.5625 1 1 protein binding "Pf13889, Pf13915" 56204 ENSG00000047346.12 FAM214A 15 0 Medium Q9H9Y2 Ribosome production factor 1 OS=Homo sapiens OX=9606 GN=RPF1 PE=1 SV=2 0.031 1.267 3 1 2 1 349 40.1 10.01 1 1 1 1 305180.25 75711.78125 672897.375 711943.125 1 1 1 1 cell organization and biogenesis;metabolic process nucleus protein binding;RNA binding Pf04427 80135 ENSG00000117133.10 RPF1 1 0 High Q9NPJ6 Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1 0 4.558 9 2 2 2 270 29.7 5.1 1 1 1 1 308232.9375 300658.4375 339987.625 146887 1 1 1 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity Pf10018 29079 ENSG00000136146.14 MED4 13 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High P32929 Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3 0 3.525 6 2 2 2 405 44.5 6.7 2 2 655834.2188 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;protein binding "Pf00155, Pf00266, Pf01041, Pf01053" 1491 ENSG00000116761.11 CTH 1 "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Degradation of cysteine and homocysteine; Cysteine formation from homocysteine" "Glycine, serine and threonine metabolism; Selenocompound metabolism; Biosynthesis of amino acids; Metabolic pathways; Cysteine and methionine metabolism" 0 High Q13011 "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" 0 6.49 11 2 2 2 328 35.8 8 2 2 1566212.375 170776.5156 208568.1719 2 1 1 metabolic process membrane;mitochondrion catalytic activity;protein binding Pf00378 1891 ENSG00000282853.1; ENSG00000104823.8 ECH1 19; CHR_HG26_PATCH Peroxisome 0 High O00148 ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2 0 7.479 6 2 2 2 427 49.1 5.68 2 2 473419.7188 326072.7188 1836396.75 702724.4375 1 1 2 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf14617" 10212 ENSG00000123136.14 DDX39A 19 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing 0 High O75600 "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1" 0 4.272 6 2 2 2 419 45.3 8.05 1 1 1 1 340079.6563 219464.9844 1 1 metabolic process membrane;mitochondrion;nucleus catalytic activity "Pf00155, Pf00266" 23464 ENSG00000100116.16 GCAT 22 Threonine catabolism "Glycine, serine and threonine metabolism" 0 High P17812 CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2 0 3.638 3 1 2 1 591 66.6 6.46 1 1 1 1 254370.1875 468702.2188 793892.3125 668997.75 1 1 1 1 cell proliferation;metabolic process;response to stimulus cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00117, Pf06418, Pf07722" 1503 ENSG00000171793.13 CTPS1 1 Interconversion of nucleotide di- and triphosphates Metabolic pathways; Pyrimidine metabolism 0 High Q9Y4E8 Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3 0 3.833 2 2 2 2 981 112.3 5.22 1 1 1 1 230839.7813 346365.1875 236164.6719 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding "Pf00443, Pf06337, Pf13423, Pf14533, Pf14836" 9958 ENSG00000135655.15 USP15 12 UCH proteinases; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling 0 High Q9Y315 Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2 0.001 2.286 3 1 2 1 318 35.2 8.94 1 2 869935.5 1 metabolic process;transport cytoplasm;cytosol;extracellular;nucleus;organelle lumen catalytic activity Pf01791 51071 ENSG00000023697.12 DERA 12 Neutrophil degranulation; Pentose phosphate pathway (hexose monophosphate shunt) Pentose phosphate pathway 0 High P52434 "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" 0 5.254 13 2 2 2 150 17.1 4.68 1 1 1 1 170065.6719 192021.875 304267.9375 1 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding Pf03870 5437 ENSG00000163882.9 POLR2H 3 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism 0 High P22102 Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1 0 5.143 3 2 2 2 1010 107.7 6.7 1 1 1 1 900688.75 1 metabolic process;response to stimulus cytoplasm;cytosol catalytic activity;metal ion binding;nucleotide binding "Pf00551, Pf00586, Pf01071, Pf02222, Pf02655, Pf02769, Pf02843, Pf02844, Pf03435, Pf07478, Pf08442, Pf08443, Pf13535, Pf15632" 2618 ENSG00000159131.16 GART 21 Purine ribonucleoside monophosphate biosynthesis Antifolate resistance; Purine metabolism; One carbon pool by folate; Metabolic pathways 0 High P40616 ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1 0 6.234 8 1 2 1 181 20.4 5.72 1 1 1 1 431031.75 543005.3594 848790.4375 815477.6875 1 2 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 400 ENSG00000120805.13 ARL1 12 Retrograde transport at the Trans-Golgi-Network 0 Medium P07737 Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2 0.028 1.296 10 1 2 1 140 15 8.27 1 1 1 1 308276.5938 373235.7813 950670.3125 453940.0313 1 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;nucleotide binding;protein binding;RNA binding Pf00235 5216 ENSG00000108518.7 PFN1 17 Platelet degranulation ; Signaling by ROBO receptors; RHO GTPases Activate Formins; PCP/CE pathway Rap1 signaling pathway; Salmonella infection; Regulation of actin cytoskeleton; Shigellosis 0 High P41250 Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3 0 5.004 3 2 2 2 739 83.1 7.03 1 1 1 1 544899 1 metabolic process cytoplasm;cytosol;extracellular;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00458, Pf00587, Pf03129" 2617 ENSG00000106105.13 GARS 7 Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High P30041 Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3 0 3.284 14 2 2 2 224 25 6.38 2 2 84389.72656 150357.7813 475662.25 153352.9219 1 1 1 1 Met-loss [N-Term] cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;vacuole antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 9588 ENSG00000117592.8 PRDX6 1 Neutrophil degranulation; Detoxification of Reactive Oxygen Species Metabolic pathways 0 High O95158 Neurexophilin-4 OS=Homo sapiens OX=9606 GN=NXPH4 PE=2 SV=3 0 5.861 6 2 2 2 308 33 9.86 2 2 3766100.375 2 regulation of biological process;response to stimulus extracellular protein binding Pf06312 11247 ENSG00000182379.9 NXPH4 12 0 High O75533 Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3 0.004 2.05 1 1 2 1 1304 145.7 7.09 1 1 1 1 393595.25 1719924.125 1934077.25 2360540.5 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity "Pf02161, Pf08920, Pf12815, Pf13513" 23451 ENSG00000115524.15 SF3B1 2 B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q8NBJ5 Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1 0 2.913 4 2 2 2 622 71.6 7.31 2 2 284621.75 205319.2969 511406.2813 959535.9375 1 1 1 1 endoplasmic reticulum;membrane;organelle lumen catalytic activity "Pf00535, Pf01755, Pf13641" 79709 ENSG00000130309.10 COLGALT1; GLT25D1 19 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 0 High P49458 Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2 0 3.367 13 1 2 1 86 10.1 7.97 1 1 1 1 620985.3125 943826.75 1006848 606121.6875 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol protein binding;RNA binding Pf05486 6726; 653226 ENSG00000143742.12 SRP9; SRP9P1 1; 10 SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q5VUD6 Divergent protein kinase domain 1B OS=Homo sapiens OX=9606 GN=DIPK1B PE=1 SV=3 0 5.082 5 2 2 2 431 48.6 8.68 2 2 1014074.781 2 endoplasmic reticulum;membrane protein binding "Pf12260, Pf14875" 138311 ENSG00000165716.10 FAM69B 9 0 High Q9Y3I1 F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1 0.001 2.204 3 1 2 1 522 58.5 6.55 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;protein binding "Pf11566, Pf12937" 25793 ENSG00000100225.17 FBXO7 22 Antigen processing: Ubiquitination & Proteasome degradation; Neddylation 0 High P07339 Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1 0 2.956 2 1 2 1 412 44.5 6.54 1 2 1220079.125 370745.3125 1 1 metabolic process;transport extracellular;membrane;organelle lumen;vacuole catalytic activity;protein binding "Pf00026, Pf07966, Pf14541, Pf14543" 1509 ENSG00000117984.13 CTSD 11 Collagen degradation; Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation; MHC class II antigen presentation Lysosome; Tuberculosis; Apoptosis; Sphingolipid signaling pathway 0 High P23258 Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2 0.003 2.098 2 1 2 1 451 51.1 6.14 1 1 1 1 491446.5625 227790.9688 295391.9063 258929.9063 1 1 1 1 cell organization and biogenesis;regulation of biological process chromosome;cytoplasm;cytoskeleton;cytosol;endosome catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" 7283 ENSG00000131462.7 TUBG1 17 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High Q9UKX7 Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2 0 5.134 7 2 2 2 468 50.1 7.06 2 2 712613.1563 158881.6563 163567.5938 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;nucleus protein binding "Pf00638, Pf08911" 10762 ENSG00000093000.18 NUP50 22 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High P52815 "39S ribosomal protein L12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" 0 5.284 11 2 2 2 198 21.3 8.87 2 2 424751.4609 418509.3906 1886833.938 423783.7813 2 2 2 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00542 6182 ENSG00000262814.7 MRPL12 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q12996 Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1 0 2.677 3 2 2 2 717 82.9 8.12 2 2 1568828.844 526937.9375 503360.5313 2 1 1 metabolic process nucleus protein binding;RNA binding Pf05843 1479 ENSG00000176102.11 CSTF3 11 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High P11047 Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3 0 5.664 3 2 2 2 1609 177.5 5.12 2 2 440350.9063 189814.4844 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process extracellular;organelle lumen catalytic activity;motor activity;protein binding;structural molecule activity "Pf00052, Pf00053, Pf00055, Pf00261, Pf01576, Pf05262, Pf05483, Pf05557, Pf05667, Pf05701, Pf06008, Pf08317, Pf10174, Pf11068, Pf12128, Pf12795, Pf13166, Pf13514, Pf13868" 3915 ENSG00000135862.5 LAMC1 1 ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions Amoebiasis; Prion diseases; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1 0 7.877 6 2 2 2 447 51.7 6.2 2 2 519375.7813 1230198.734 1032760.25 2055737 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol catalytic activity;enzyme regulator activity;protein binding 5520 ENSG00000221914.9 PPP2R2A 8 Cyclin D associated events in G1; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Initiation of Nuclear Envelope Reformation; Cyclin A/B1/B2 associated events during G2/M transition Dopaminergic synapse; Chagas disease (American trypanosomiasis); Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; mRNA surveillance pathway; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway 0 High Q53HC5 Kelch-like protein 26 OS=Homo sapiens OX=9606 GN=KLHL26 PE=1 SV=2 0 5.16 7 2 2 2 615 68.1 6.48 2 2 991912.6563 2 Met-loss+Acetyl [N-Term] metabolic process cytoplasm catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964" 55295 ENSG00000167487.11 KLHL26 19 0 High P07355 Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2 0 7.865 9 2 2 2 339 38.6 7.75 2 2 997684.4375 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;membrane;nucleus;organelle lumen enzyme regulator activity;metal ion binding;protein binding;RNA binding Pf00191 302 ENSG00000182718.16 ANXA2 15 Dissolution of Fibrin Clot; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Neutrophil degranulation; Interleukin-12 family signaling 0 High Q8NE01 Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1 0 4.255 4 2 2 2 707 76.1 6.09 2 2 818626.5 2 transport membrane protein binding Pf00571 26505 ENSG00000168763.15 CNNM3 2 0 High P08069 Insulin-like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 0.001 2.363 1 1 2 1 1367 154.7 5.8 1 1 1 1 318787.6875 552853.0625 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00041, Pf00069, Pf00757, Pf01030, Pf01826, Pf07714, Pf14843" 3480 ENSG00000140443.13 IGF1R 15 IRS-related events triggered by IGF1R; SHC-related events triggered by IGF1R Endocytosis; Longevity regulating pathway - multiple species; HIF-1 signaling pathway; Ovarian steroidogenesis; FoxO signaling pathway; Rap1 signaling pathway; Progesterone-mediated oocyte maturation; Breast cancer; Pathways in cancer; Prostate cancer; Glioma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Focal adhesion; Proteoglycans in cancer; AMPK signaling pathway; mTOR signaling pathway; Transcriptional misregulation in cancer; Adherens junction; Long-term depression; Oocyte meiosis; Ras signaling pathway; Endocrine resistance; Signaling pathways regulating pluripotency of stem cells; Longevity regulating pathway; PI3K-Akt signaling pathway 0 High Q9Y2R9 "28S ribosomal protein S7, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" 0 3.689 10 2 2 2 242 28.1 9.99 1 1 1 1 540763.625 619402.625 827240.25 1566774.625 1 1 1 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf00177 51081 ENSG00000125445.10 MRPS7 17 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Medium Q6ZT12 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens OX=9606 GN=UBR3 PE=2 SV=2 0.047 1.07 0 1 2 1 1888 212.3 6.1 1 1 1 1 12561794 650283.125 1080590.75 1 1 1 metabolic process;response to stimulus cytoplasm;membrane catalytic activity;metal ion binding Pf02207 130507 ENSG00000144357.16 UBR3 2 0 High Q9NZV5 Selenoprotein N OS=Homo sapiens OX=9606 GN=SELENON PE=1 SV=5 0 5.098 3 2 2 2 590 65.8 5.48 2 2 79179.63281 1140605.844 1 2 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding 57190 ENSG00000162430.16 SEPN1; SELENON 1 0 High Q13573 SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1 0 4.758 6 2 2 2 536 61.5 9.52 2 2 908656.4063 674046.3125 326137.9688 571719.375 2 2 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex catalytic activity;protein binding;RNA binding Pf02731 22938 ENSG00000100603.13 SNW1 14 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; mRNA Splicing - Major Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation Viral carcinogenesis; Epstein-Barr virus infection; Spliceosome; Notch signaling pathway 0 High P21912 "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" 0 2.517 8 2 2 2 280 31.6 8.76 2 2 491807.5586 1451239.781 703329 404815.5449 2 2 1 2 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf13085, Pf13183, Pf13534" 6390 ENSG00000117118.9 SDHB 1 Respiratory electron transport; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q96K37 Solute carrier family 35 member E1 OS=Homo sapiens OX=9606 GN=SLC35E1 PE=1 SV=2 0 4.356 9 2 2 2 410 44.7 9.79 2 2 341165.8438 1225772.5 1 2 Met-loss+Acetyl [N-Term] transport Golgi;membrane "Pf03151, Pf08449" 79939 ENSG00000127526.14 SLC35E1 19 0 High Q99733 Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1 0 5.313 8 2 2 2 375 42.8 4.69 2 2 278498.25 507328.5313 605402.8125 520564 1 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;nucleus protein binding;RNA binding Pf00956 4676 ENSG00000273562.4; ENSG00000205531.12 NAP1L4 11; CHR_HSCHR11_1_CTG7 0 High Q9BYN8 "28S ribosomal protein S26, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" 0.004 2.06 4 1 2 1 205 24.2 10.39 1 1 1 1 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome RNA binding Pf14943 64949 ENSG00000125901.5 MRPS26 20 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High P36952 Serpin B5 OS=Homo sapiens OX=9606 GN=SERPINB5 PE=1 SV=2 0 2.884 4 2 2 2 375 42.1 6.05 2 2 1546735.813 2 cell organization and biogenesis;cellular component movement;regulation of biological process cytoplasm;extracellular enzyme regulator activity;protein binding Pf00079 5268 ENSG00000206075.13 SERPINB5 18 MicroRNAs in cancer; p53 signaling pathway 0 Low Q6IQ20 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Homo sapiens OX=9606 GN=NAPEPLD PE=1 SV=2 0.052 0.992 2 1 2 1 393 45.6 6.06 1 1 1 1 1646986.5 2182727 427018.625 1 1 1 metabolic process;response to stimulus cytosol;membrane catalytic activity;metal ion binding;protein binding "Pf00753, Pf12706, Pf13483" 222236 ENSG00000161048.11; ENSG00000275723.4 NAPEPLD 7; CHR_HSCHR7_1_CTG4_4 "Signaling by GPCR; Biosynthesis of A2E, implicated in retinal degradation" Retrograde endocannabinoid signaling 0 High P23921 Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1 0 3.203 5 2 2 2 792 90 7.15 1 1 1 1 metabolic process cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding "Pf00317, Pf02867, Pf03477" 6240 ENSG00000167325.14 RRM1 11 Interconversion of nucleotide di- and triphosphates Glutathione metabolism; Purine metabolism; Metabolic pathways; Pyrimidine metabolism 0 High Q9BVX2 Transmembrane protein 106C OS=Homo sapiens OX=9606 GN=TMEM106C PE=1 SV=1 0 8.685 7 1 2 1 250 27.9 6.77 1 2 1247166.375 1 endoplasmic reticulum;membrane protein binding Pf07092 79022 ENSG00000134291.11 TMEM106C 12 0 High O14893 Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1 0 4.161 7 1 2 1 280 31.6 5.58 1 2 684519.5625 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding Pf04938 8487 ENSG00000092208.16 GEMIN2 14 snRNP Assembly RNA transport 0 High Q9HCY8 Protein S100-A14 OS=Homo sapiens OX=9606 GN=S100A14 PE=1 SV=1 0 6.574 21 2 2 2 104 11.7 5.24 2 2 310807.5 1455768.813 83514.71094 2 2 1 cell death;defense response;regulation of biological process;response to stimulus cytoplasm;cytosol metal ion binding;protein binding Pf01023 57402 ENSG00000189334.8 S100A14 1 0 High P60228 Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1 0 4.29 7 2 2 2 445 52.2 6.04 1 1 1 1 139487.7031 233495.4375 274336.2188 223703.9688 1 1 1 1 metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf01399, Pf09440" 3646 ENSG00000104408.9 EIF3E 8 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport; Hepatitis C 0 High P49841 Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2 0 2.84 7 2 2 1 420 46.7 8.78 1 1 1 1 179436.625 768205.5625 440697.2813 1 1 1 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714, Pf14531" 2932 ENSG00000082701.14 GSK3B 3 Regulation of RUNX2 expression and activity; AKT phosphorylates targets in the cytosol; S37 mutants of beta-catenin aren't phosphorylated; Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; S33 mutants of beta-catenin aren't phosphorylated; CRMPs in Sema3A signaling; Regulation of HSF1-mediated heat shock response; Disassembly of the destruction complex and recruitment of AXIN to the membrane; APC truncation mutants have impaired AXIN binding; S45 mutants of beta-catenin aren't phosphorylated; GLI3 is processed to GLI3R by the proteasome; Misspliced GSK3beta mutants stabilize beta-catenin; Constitutive Signaling by AKT1 E17K in Cancer; Degradation of GLI2 by the proteasome; T41 mutants of beta-catenin aren't phosphorylated; B-WICH complex positively regulates rRNA expression; Truncations of AMER1 destabilize the destruction complex Dopaminergic synapse; T cell receptor signaling pathway; Insulin signaling pathway; Prolactin signaling pathway; Epstein-Barr virus infection; Neurotrophin signaling pathway; B cell receptor signaling pathway; Hippo signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; EGFR tyrosine kinase inhibitor resistance; HTLV-I infection; Melanogenesis; Wnt signaling pathway; Focal adhesion; Alzheimer's disease; mTOR signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Hedgehog signaling pathway; Measles; Hepatitis C; Cell cycle; Chemokine signaling pathway; Axon guidance; Basal cell carcinoma; Signaling pathways regulating pluripotency of stem cells; Influenza A; Insulin resistance; PI3K-Akt signaling pathway 0 High Q9BX73 TM2 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TM2D2 PE=1 SV=1 0 2.727 13 1 2 1 214 22.9 4.97 1 1 1 1 389783.4375 344769.375 1 1 membrane Pf05154 83877 ENSG00000169490.16 TM2D2 8 0 High Q04727 Transducin-like enhancer protein 4 OS=Homo sapiens OX=9606 GN=TLE4 PE=1 SV=3 0 5.256 3 2 2 1 773 83.7 7.5 2 2 75309.78906 63293.70703 6103.958008 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding "Pf00400, Pf03920" 7091 ENSG00000106829.18 TLE4 9 NOTCH1 Intracellular Domain Regulates Transcription; Repression of WNT target genes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex 0 High Q9BT67 NEDD4 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=NDFIP1 PE=1 SV=1 0 4.169 8 1 2 1 221 24.9 4.68 1 1 1 1 72143.02344 84067.46875 1 1 Met-loss+Acetyl [N-Term] cellular homeostasis;regulation of biological process;response to stimulus;transport endosome;extracellular;Golgi;membrane protein binding;signal transducer activity Pf10176 80762 ENSG00000131507.10 NDFIP1 5 0 High O75478 Transcriptional adapter 2-alpha OS=Homo sapiens OX=9606 GN=TADA2A PE=1 SV=3 0 3.13 2 1 2 1 443 51.5 6.89 1 1 1 1 441273.125 295703.8125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;protein binding "Pf00249, Pf04433" 6871 ENSG00000277104.4 TADA2A 17; CHR_HSCHR17_7_CTG4 HATs acetylate histones 0 Medium A0A075B6I1 Immunoglobulin lambda variable 4-60 OS=Homo sapiens OX=9606 GN=IGLV4-60 PE=3 SV=1 0.011 1.564 8 1 2 1 120 13 6.25 1 2 8464171 1 response to stimulus extracellular;membrane Pf07686 28785 ENSG00000211639.2 IGLV4-60 22 0 High Q01469 Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3 0 6.743 18 2 2 2 135 15.2 7.01 2 2 323683.5313 285738.1563 3021255.781 214912.7031 1 1 2 1 Met-loss+Acetyl [N-Term] metabolic process;transport cytoplasm;cytosol;extracellular;membrane;organelle lumen protein binding;transporter activity Pf00061 2171 ENSG00000164687.10 FABP5 8 Triglyceride catabolism; Signaling by Retinoic Acid; Neutrophil degranulation PPAR signaling pathway 0 Medium P62995 Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1 0.031 1.277 3 1 2 1 288 33.6 11.25 1 1 1 1 423619.6875 893044.1875 669701.875 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 6434 ENSG00000136527.17 TRA2B 3 mRNA Splicing - Major Pathway Spliceosome 0 High Q9BUE0 Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1 0 2.699 12 2 2 2 208 23.6 6.54 1 1 1 1 499483.5313 183911.4844 131925.5625 244267.9063 2 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf09637 54797 ENSG00000130772.13 MED18 1 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 High Q01658 Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1 0.007 1.689 4 1 2 1 176 19.4 4.75 1 1 1 1 665321.8125 352640.7813 343836.9375 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf00808 1810 ENSG00000117505.12 DR1 1 HATs acetylate histones 0 Medium Q5XKP0 MICOS complex subunit MIC13 OS=Homo sapiens OX=9606 GN=MICOS13 PE=1 SV=1 0.036 1.192 5 1 2 1 118 13.1 9.42 1 1 1 1 118870.4375 300618.25 943629.0625 1379279.75 1 1 1 1 cell organization and biogenesis membrane;mitochondrion 125988 ENSG00000174917.8 C19orf70 19 Cristae formation 0 High Q00266 S-adenosylmethionine synthase isoform type-1 OS=Homo sapiens OX=9606 GN=MAT1A PE=1 SV=2 0.001 2.326 3 1 2 1 395 43.6 6.29 1 1 1 1 404631.5 467794.5938 784668.5 1 1 1 cell organization and biogenesis;metabolic process cytosol catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00438, Pf02772, Pf02773" 4143 ENSG00000151224.12 MAT1A 10 "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Sulfur amino acid metabolism; Methylation; Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)" Biosynthesis of amino acids; Metabolic pathways; Cysteine and methionine metabolism 0 High Q8NI27 THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2 0 2.66 1 2 2 2 1593 182.7 8.44 1 1 1 1 475707.375 286448.5859 372167.9844 247350.1563 2 2 2 1 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport nucleus protein binding;RNA binding "Pf11262, Pf11732" 57187 ENSG00000125676.19 THOC2 X Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing Spliceosome; RNA transport 0 High Q9P219 Protein Daple OS=Homo sapiens OX=9606 GN=CCDC88C PE=1 SV=3 0 4.361 1 2 2 2 2028 228.1 6.23 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding "Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf09726, Pf09728, Pf12128, Pf13514, Pf14915" 440193 ENSG00000015133.18 CCDC88C 14 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0 High O75367 Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=4 0.001 2.426 4 2 2 2 372 39.6 9.79 2 2 84750.78125 946664.6875 141208.3594 1 2 1 cell organization and biogenesis;regulation of biological process chromosome;nucleus DNA binding;enzyme regulator activity;protein binding "Pf00125, Pf01661" 9555 ENSG00000113648.16 H2AFY 5 Systemic lupus erythematosus; Alcoholism 0 High O75521 "Enoyl-CoA delta isomerase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" 0 5.537 4 1 2 1 394 43.6 9 1 2 796299.375 203172.8125 331108.5938 1 1 1 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf00378, Pf00887" 10455 ENSG00000198721.12 ECI2 6 Peroxisome; Fatty acid degradation 0 High Q5C9Z4 Nucleolar MIF4G domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOM1 PE=1 SV=1 0 4.491 2 1 2 1 860 96.2 8.1 1 1 1 1 189098.4375 330727.7188 1 1 cell differentiation nucleus protein binding;RNA binding "Pf02847, Pf02854" 64434 ENSG00000146909.7 NOM1 7 0 Medium Q9Y5L0 Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3 0.011 1.579 3 1 2 1 923 104.1 5.57 1 1 1 1 10800661.5 15412274.25 6059450.625 1 1 1 Acetyl [N-Term] transport cytoplasm;membrane;nucleus protein binding;receptor activity;transporter activity Pf08389 23534 ENSG00000064419.13 TNPO3 7 0 High Q9Y4W6 AFG3-like protein 2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2 0 5.119 2 2 2 2 797 88.5 8.66 1 1 1 1 128331.625 319178.1875 368578.4375 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01434, Pf05496, Pf06068, Pf06480, Pf07724, Pf07728, Pf13191, Pf13401" 10939 ENSG00000141385.9 AFG3L2 18 Processing of SMDT1 0 High O15397 Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2 0.001 2.398 1 1 2 1 1037 119.9 5.16 1 1 1 1 611844.9375 565231.3125 395257.4063 1 1 1 regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;transporter activity "Pf03810, Pf08506" 10526 ENSG00000133704.9 IPO8 12 Transcriptional regulation by small RNAs 0 High Q9ULH1 "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" 0 4.285 2 2 2 2 1129 125.4 7.31 1 1 1 1 347365.4688 326649.375 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00018, Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857, Pf14604" 50807 ENSG00000153317.14 ASAP1 8 VxPx cargo-targeting to cilium Endocytosis; Fc gamma R-mediated phagocytosis 0 High P16401 Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3 0 4.175 9 2 2 1 226 22.6 10.92 2 2 1268350.875 1 cell organization and biogenesis;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 3009 ENSG00000184357.4 HIST1H1B 6 Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor 0 High Q9P0J0 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Homo sapiens OX=9606 GN=NDUFA13 PE=1 SV=3 0 3.32 16 2 2 2 144 16.7 8.43 2 2 381559.375 515886.1563 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding Pf06212 51079 ENSG00000186010.18 NDUFA13 19 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q8TF09 Dynein light chain roadblock-type 2 OS=Homo sapiens OX=9606 GN=DYNLRB2 PE=1 SV=1 0 4.105 23 2 2 2 96 10.8 7.5 2 2 855372.4375 825460.0625 927645.5625 952931.875 1 1 1 1 Met-loss+Acetyl [N-Term] cellular component movement;transport cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding Pf03259 83657 ENSG00000168589.14 DYNLRB2 16 Intraflagellar transport 0 High Q16576 Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1 0.002 2.165 6 1 2 1 425 47.8 5.05 1 1 1 1 518761.1875 406163.25 372356.5 551470.0625 1 1 1 1 cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;protein binding;RNA binding "Pf00400, Pf12265" 5931 ENSG00000102054.17 RBBP7 X RMTs methylate histone arginines; Regulation of TP53 Activity through Acetylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HATs acetylate histones; Neddylation; Deposition of new CENPA-containing nucleosomes at the centromere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; HDACs deacetylate histones; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation 0 High Q9NT22 EMILIN-3 OS=Homo sapiens OX=9606 GN=EMILIN3 PE=1 SV=2 0 8.052 5 2 2 2 766 82.6 7.72 2 2 1382173.438 2 cell organization and biogenesis cytoplasm;cytoskeleton;extracellular protein binding "Pf06160, Pf07546" 90187 ENSG00000183798.4 EMILIN3 20 Molecules associated with elastic fibres 0 High P58107 Epiplakin OS=Homo sapiens OX=9606 GN=EPPK1 PE=1 SV=3 0 2.86 4 2 2 2 5088 555.3 5.62 1 1 1 1 741767.125 355017.6875 485801.6875 394095.2188 1 1 1 1 0 High P48643 T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1 0.006 1.848 1 1 2 1 541 59.6 5.66 1 1 1 1 258642.9063 426826.3438 598864.1875 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 22948 ENSG00000150753.11 CCT5 5 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC 0 High P52732 Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2 0 2.975 2 2 2 2 1056 119.1 5.64 2 2 613390.375 91931.78125 2 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf13931" 3832 ENSG00000138160.5 KIF11 10 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation 0 Medium O43432 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2 0.013 1.496 1 1 2 1 1585 176.5 5.38 1 1 1 1 1866284.125 2180435.25 1893144 2454631.25 1 1 1 1 metabolic process;regulation of biological process cytosol protein binding;RNA binding "Pf02020, Pf02847, Pf02854" 8672 ENSG00000075151.20 EIF4G3 1 ISG15 antiviral mechanism RNA transport; Viral myocarditis 0 High Q8NFZ0 F-box DNA helicase 1 OS=Homo sapiens OX=9606 GN=FBH1 PE=1 SV=2 0 4.331 3 2 2 2 1043 117.6 8.25 2 2 182048.2813 406052.4688 214662.625 1 1 1 cell death;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00580, Pf00646, Pf12937, Pf13086, Pf13245, Pf13361, Pf13538" 84893 ENSG00000134452.19 FBXO18 10 0 High O43813 Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1 0 4.146 5 2 2 2 399 45.3 7.75 1 1 1 1 691834.8125 844064.625 881863.5 611426.2031 2 2 2 2 regulation of biological process;response to stimulus cytoplasm;membrane metal ion binding;protein binding;receptor activity;signal transducer activity Pf05147 10314 ENSG00000115365.11 LANCL1 2 0 High Q5JW98 Calcium homeostasis modulator protein 4 OS=Homo sapiens OX=9606 GN=CALHM4 PE=2 SV=1 0 4.133 7 2 2 2 314 35 6.87 2 2 659776.2813 2 transport membrane transporter activity Pf14798 221301 ENSG00000164451.13 FAM26D; CALHM4 6 0 High P98170 E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2 0 3.546 4 1 2 1 497 56.6 6.65 1 1 1 1 477340.0313 1168691.375 827319.9375 567394.5 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;metal ion binding;protein binding "Pf00653, Pf13920, Pf13923" 331 ENSG00000101966.12 XIAP X Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization NOD-like receptor signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Apoptosis - multiple species; NF-kappa B signaling pathway; HTLV-I infection; Toxoplasmosis; Apoptosis; Focal adhesion; Small cell lung cancer; Platinum drug resistance 0 High P13073 "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" 0.006 1.837 6 1 2 1 169 19.6 9.51 1 1 1 1 152557.0938 619017.875 722002.9375 1 1 1 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf02936 1327 ENSG00000131143.8 COX4I1 16 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 Medium Q6PK04 Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1 0.042 1.125 3 1 1 1 289 33.2 10.93 1 1 12587294 8515028 12623770 10709703 1 1 1 1 chromosome protein binding;RNA binding 339230 ENSG00000185298.12 CCDC137 17 0 High P47756 F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4 0.007 1.749 4 1 1 1 277 31.3 5.59 1 1 852612.5 870211.25 1 1 cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol protein binding Pf01115 832 ENSG00000077549.17 CAPZB 1 COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Factors involved in megakaryocyte development and platelet production Endocytosis 0 Medium Q92805 Golgin subfamily A member 1 OS=Homo sapiens OX=9606 GN=GOLGA1 PE=1 SV=3 0.01 1.54 1 1 1 1 767 88.1 5.27 1 1 226560.5156 180939.9688 1 1 metabolic process;transport cytosol;Golgi;membrane catalytic activity;motor activity;protein binding;transporter activity "Pf01465, Pf01496, Pf01576, Pf04111, Pf04156, Pf04849, Pf07888, Pf08317, Pf10212, Pf12128, Pf13166" 2800 ENSG00000136935.13 GOLGA1 9 Retrograde transport at the Trans-Golgi-Network 0 Low Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=4 0.055 0.97 1 1 1 1 930 103.3 6.98 1 1 90164.48438 120922.2422 302900.2188 287035.4063 1 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;organelle lumen enzyme regulator activity;protein binding "Pf00092, Pf06668, Pf08487, Pf10138, Pf13444, Pf13519, Pf13768" 3700 ENSG00000055955.15 ITIH4 3 Platelet degranulation 0 High P13995 "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" 0.007 1.74 3 1 1 1 350 37.9 8.73 1 1 281014.5625 414838.6875 733178.25 508138.625 1 1 1 1 metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf00763, Pf02882" 10797 ENSG00000065911.11 MTHFD2 2 Metabolism of folate and pterines One carbon pool by folate; Metabolic pathways 0 Medium Q674R7 Autophagy-related protein 9B OS=Homo sapiens OX=9606 GN=ATG9B PE=1 SV=1 0.047 1.085 2 1 1 1 924 101 8.28 1 1 cell organization and biogenesis;metabolic process cytoplasm;membrane;vacuole Pf04109 285973 ENSG00000181652.19 ATG9B 7 Macroautophagy 0 High Q8N983 "39S ribosomal protein L43, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" 0.001 2.425 5 1 1 1 215 23.4 8.65 1 1 201611.9375 441584.1875 326243.9688 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf05047 84545 ENSG00000055950.16 MRPL43 10 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O43303 Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3 0 2.734 1 1 1 1 1012 113.4 8.65 1 1 194396.2656 885825.875 310165.5313 374056.9063 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding 9738 ENSG00000103540.16 CCP110 16 Ub-specific processing proteases; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High P56537 Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1 0 2.708 7 1 1 1 245 26.6 4.68 1 1 361039.7188 672291.375 223887.3594 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus protein binding;RNA binding Pf01912 3692 ENSG00000242372.6 EIF6 20 Ribosome biogenesis in eukaryotes 0 High P67812 Signal peptidase complex catalytic subunit SEC11A OS=Homo sapiens OX=9606 GN=SEC11A PE=1 SV=1 0.001 2.41 4 1 1 1 179 20.6 9.48 1 1 156990.4219 909307.8125 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity Pf00717 23478 ENSG00000140612.13 SEC11A 15 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)" Protein export 0 High Q14703 Membrane-bound transcription factor site-1 protease OS=Homo sapiens OX=9606 GN=MBTPS1 PE=1 SV=1 0 3.777 1 1 1 1 1052 117.7 8.75 1 1 1095449.625 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane;organelle lumen catalytic activity "Pf00082, Pf14258" 8720 ENSG00000140943.16 MBTPS1 16 Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Assembly of active LPL and LIPC lipase complexes; Regulation of cholesterol biosynthesis by SREBP (SREBF); CREB3 factors activate genes; ATF6 (ATF6-alpha) activates chaperones Protein processing in endoplasmic reticulum 0 High A6NFN3 RNA binding protein fox-1 homolog 3 OS=Homo sapiens OX=9606 GN=RBFOX3 PE=2 SV=4 0.001 2.423 3 1 1 1 312 33.9 7.27 1 1 125765.6094 291442.5 1 1 metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;RNA binding "Pf00076, Pf08777, Pf12414, Pf13893, Pf14259" 146713 ENSG00000167281.18 RBFOX3 17 0 Medium Q12907 Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1 0.049 1.034 3 1 1 1 356 40.2 6.95 1 1 218600.3594 214430.1094 1 1 regulation of biological process;transport cell surface;endoplasmic reticulum;Golgi;membrane metal ion binding;protein binding Pf03388 10960 ENSG00000169223.14 LMAN2 5 Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport Protein processing in endoplasmic reticulum 0 Medium Q9Y5Z9 UbiA prenyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBIAD1 PE=1 SV=1 0.028 1.327 3 1 1 1 338 36.8 8.15 1 1 84567.70313 425772.3125 1 1 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;endoplasmic reticulum;Golgi;membrane;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding Pf01040 29914 ENSG00000120942.13 UBIAD1 1 Metabolism of vitamin K 0 High O43805 Sjoegren syndrome nuclear autoantigen 1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2 0.007 1.668 9 1 1 1 119 13.6 5.38 1 1 383157.125 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus protein binding "Pf04111, Pf08149" 8636 ENSG00000176101.11 SSNA1 9 Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High Q14165 Malectin OS=Homo sapiens OX=9606 GN=MLEC PE=1 SV=1 0.007 1.759 4 1 1 1 292 32.2 5.41 1 1 metabolic process;transport endoplasmic reticulum;membrane protein binding Pf11721 9761 ENSG00000110917.7 MLEC 12 Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0 High P54105 Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1 0 3.421 5 1 1 1 237 26.2 4.11 1 1 357580.9063 288276.8438 334577.8125 401598.875 1 1 1 1 cell organization and biogenesis;cellular homeostasis;transport cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding Pf03517 1207 ENSG00000074201.8 CLNS1A 11 snRNP Assembly RNA transport 0 High Q08AM6 Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1 0.001 2.442 2 1 1 1 782 87.9 6.13 1 1 869115.1875 161067.2656 161976.625 1 1 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;endosome;membrane protein binding;receptor activity "Pf11916, Pf12755" 55697 ENSG00000103043.14 VAC14 16 Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane Viral carcinogenesis; HTLV-I infection 0 High Q9NVE7 4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1 0 3.18 2 1 1 1 773 85.9 6.28 1 1 421984.9688 116285.8984 1 1 metabolic process cytoplasm catalytic activity;nucleotide binding "Pf01937, Pf03630" 55229 ENSG00000273494.3 PANK4 1; CHR_HSCHR1_1_CTG3 Coenzyme A biosynthesis Pantothenate and CoA biosynthesis; Metabolic pathways 0 Medium O94832 Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2 0.016 1.461 1 1 1 1 1006 116.1 9.39 1 1 202931.3438 1 regulation of biological process;transport cytosol;endoplasmic reticulum;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 4642 ENSG00000176658.16 MYO1D 17 0 Low Q9Y3B7 "39S ribosomal protein L11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" 0.052 0.986 4 1 1 1 192 20.7 9.91 1 1 469372.2813 637739.6875 414710.0938 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 65003 ENSG00000174547.13 MRPL11 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High O95926 Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1 0 3.838 12 1 1 1 243 28.7 8.4 1 1 270154.4688 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex protein binding;RNA binding Pf08231 25949 ENSG00000117614.9 SYF2 1 mRNA Splicing - Major Pathway Spliceosome 0 High O75934 Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1 0.003 2.076 13 1 1 1 225 26.1 5.66 1 1 56684.80469 74497.10938 173373.625 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process nucleus;spliceosomal complex protein binding Pf05700 10286 ENSG00000116752.5 BCAS2 1 mRNA Splicing - Major Pathway Spliceosome 0 Low Q9NYZ3 G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=3 0.055 0.969 1 1 1 1 720 76.6 9.39 1 1 306756.0313 283300.0625 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding Pf15259 51512 GTSE1 22 The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M Checkpoints p53 signaling pathway 0 Medium Q9Y5Q8 General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2 0.047 1.085 2 1 1 1 519 59.5 6.9 1 1 258708.4063 59492.26563 158408.7344 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process nucleus DNA binding;protein binding Pf09734 9328 ENSG00000148308.17 GTF3C5 9 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 Low Q8IV38 Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1 0.055 0.97 8 1 1 1 441 49.3 6.25 1 1 248498.5156 391770.9688 1 1 regulation of biological process metal ion binding;protein binding "Pf00023, Pf01753, Pf12796, Pf13606, Pf13637, Pf13857" 57037 ENSG00000106524.8 ANKMY2 7 0 High Q16718 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Homo sapiens OX=9606 GN=NDUFA5 PE=1 SV=3 0.001 2.367 14 1 1 1 116 13.5 5.99 1 1 169440.4219 261450.8438 285024.375 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;protein binding Pf04716 4698 ENSG00000128609.14 NDUFA5 7 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High P09110 "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" 0.007 1.782 2 1 1 1 424 44.3 8.44 1 1 metabolic process;transport extracellular;membrane;organelle lumen catalytic activity;protein binding "Pf00108, Pf02803, Pf08541" 30 ENSG00000060971.17 ACAA1 3 Neutrophil degranulation; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids "Peroxisome; Fatty acid degradation; PPAR signaling pathway; Biosynthesis of unsaturated fatty acids; alpha-Linolenic acid metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism" 0 Medium O95429 BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1 0.03 1.281 6 1 1 1 457 49.6 5.12 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus enzyme regulator activity;nucleotide binding;protein binding;RNA binding;signal transducer activity Pf02179 9530 ENSG00000156735.10 BAG4 8 Regulation of HSF1-mediated heat shock response; TNF signaling; Signaling by plasma membrane FGFR1 fusions TNF signaling pathway 0 Medium Q7Z406 Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2 0.036 1.186 0 1 1 1 1995 227.7 5.6 1 1 116917.8047 355790.1563 1261801.375 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf01576" 79784 ENSG00000105357.15 MYH14 19 RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs Tight junction; Salmonella infection; Regulation of actin cytoskeleton 0 Medium Q9Y5A9 YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2 0.016 1.481 2 1 1 1 579 62.3 8.79 1 1 495510.375 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding;RNA binding Pf04146 51441 ENSG00000198492.15 YTHDF2 1 0 Medium Q2TAY7 WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2 0.015 1.434 2 1 1 1 513 57.5 7.18 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex protein binding Pf00400 55234 ENSG00000122692.8 SMU1 9 0 High Q15043 Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3 0.006 1.834 3 1 1 1 492 54.2 5.33 1 1 316068.125 387202.0313 627194.6875 1 1 1 cellular homeostasis;transport cytoplasm;membrane transporter activity Pf02535 23516 ENSG00000104635.13 SLC39A14 8 Zinc influx into cells by the SLC39 gene family 0 Medium O75935 Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1 0.035 1.23 5 1 1 1 186 21.1 5.47 1 1 330171.6563 125048.8672 162453.2813 1 1 1 Met-loss+Acetyl [N-Term] cell division;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity Pf07426 11258 ENSG00000137100.15 DCTN3 9 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) 0 High P24863 Cyclin-C OS=Homo sapiens OX=9606 GN=CCNC PE=1 SV=2 0 2.878 4 1 1 1 283 33.2 7.33 1 1 277733.8438 415721.9375 508994.5938 632502.5625 1 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;enzyme regulator activity;protein binding Pf00134 892 ENSG00000112237.12 CCNC 6 NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression 0 High Q96A35 "39S ribosomal protein L24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" 0 2.927 6 1 1 1 216 24.9 9.29 1 1 119502.6719 215503.8594 231960.8438 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome structural molecule activity Pf00467 79590 ENSG00000143314.12 MRPL24 1 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 Medium Q9NSI2 Protein FAM207A OS=Homo sapiens OX=9606 GN=FAM207A PE=1 SV=2 0.047 1.069 5 1 1 1 230 25.4 11.08 1 1 177389.7188 142677.1563 180967.5938 204968.7188 1 1 1 1 protein binding Pf15341 85395 ENSG00000160256.12 FAM207A 21 0 Medium O15417 Trinucleotide repeat-containing gene 18 protein OS=Homo sapiens OX=9606 GN=TNRC18 PE=1 SV=3 0.028 1.324 0 1 1 1 2968 314.3 8.7 1 1 56505.83203 201350.6719 130355.7734 80373.17969 1 1 1 1 cell organization and biogenesis;regulation of biological process chromosome;cytosol;membrane;mitochondrion;nucleus DNA binding Pf01426 84629 ENSG00000182095.14 TNRC18 7 0 High Q13043 Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2 0 2.573 3 1 1 1 487 55.6 5.07 1 1 358879 162786.7656 170983.2344 1 1 1 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf11629" 6789 ENSG00000101109.11 STK4 20 Signaling by Hippo FoxO signaling pathway; Non-small cell lung cancer; MAPK signaling pathway; Pathways in cancer; Ras signaling pathway 0 Medium Q14494 Endoplasmic reticulum membrane sensor NFE2L1 OS=Homo sapiens OX=9606 GN=NFE2L1 PE=1 SV=1 0.011 1.524 2 1 1 1 772 84.7 4.64 1 1 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf07716" 4779 ENSG00000082641.15 NFE2L1 17 0 Low Q9UIQ6 Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3 0.052 1.007 1 1 1 1 1025 117.3 5.73 1 1 214122.3125 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf01433, Pf11838, Pf13485" 4012 ENSG00000113441.15 LNPEP 5 Translocation of GLUT4 to the plasma membrane; Antigen processing: Ubiquitination & Proteasome degradation; Endosomal/Vacuolar pathway Renin-angiotensin system 0 High Q9NP79 Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1 0.003 2.13 5 1 1 1 307 33.9 6.29 1 1 440170.9063 1 Met-loss+Acetyl [N-Term] cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane protein binding Pf04652 51534 ENSG00000009844.15 VTA1 6 Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 Medium P35251 Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4 0.029 1.29 2 1 1 1 1148 128.2 9.36 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding "Pf00004, Pf00533, Pf03215, Pf05496, Pf06414, Pf08519, Pf12738, Pf13207, Pf13238" 5981 ENSG00000035928.15 RFC1 4 Translesion synthesis by POLK; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Dual incision in TC-NER; PCNA-Dependent Long Patch Base Excision Repair DNA replication; Mismatch repair; Nucleotide excision repair 0 Low Q9NSA3 Beta-catenin-interacting protein 1 OS=Homo sapiens OX=9606 GN=CTNNBIP1 PE=1 SV=1 0.052 1.006 7 1 1 1 81 9.2 5.41 1 1 385927.5 1 regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding Pf06384 56998 ENSG00000178585.14 CTNNBIP1 1 Deactivation of the beta-catenin transactivating complex Wnt signaling pathway 0 High Q9Y5Q9 General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1 0 3.009 1 1 1 1 886 101.2 5.07 1 1 453428.4375 141733.3281 121614.9844 1 1 1 metabolic process;regulation of biological process membrane;nucleus DNA binding;protein binding "Pf13414, Pf13424, Pf13432" 9330 ENSG00000119041.10 GTF3C3 2 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High Q9Y605 MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1 0.001 2.349 19 1 1 1 127 14.6 4.7 1 1 184100.5625 190897.2031 509342.0938 1 1 1 cytoplasm;cytosol;nucleus protein binding Pf15155 93621 ENSG00000179010.14 MRFAP1 4 0 Medium P09914 Interferon-induced protein with tetratricopeptide repeats 1 OS=Homo sapiens OX=9606 GN=IFIT1 PE=1 SV=2 0.05 1.05 3 1 1 1 478 55.3 7.2 1 1 1228614 2938672.25 1794451.375 441091.5 1 1 1 1 defense response;regulation of biological process;response to stimulus;transport cytoplasm;cytosol protein binding;RNA binding "Pf00515, Pf13176, Pf13424, Pf14559" 3434 ENSG00000185745.9 IFIT1 10 Interferon alpha/beta signaling; ISG15 antiviral mechanism Herpes simplex infection; Hepatitis C 0 High Q92820 Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2 0.007 1.693 3 1 1 1 318 35.9 7.11 1 1 468311.375 61687.79688 1 1 metabolic process;response to stimulus;transport cytosol;extracellular;nucleus;organelle lumen;vacuole catalytic activity "Pf00117, Pf07722" 8836 ENSG00000137563.11 GGH 8 Neutrophil degranulation Folate biosynthesis; Antifolate resistance 0 Medium Q8NFC6 Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2 0.046 1.096 1 1 1 1 3051 330.3 5.08 1 1 307746.3438 1 metabolic process;response to stimulus chromosome Pf05205 259282 ENSG00000038219.12 BOD1L1 4 0 High Q96P70 Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3 0.004 1.934 3 1 1 1 1041 115.9 4.81 1 1 transport cytoplasm;cytosol;membrane;nucleus protein binding;transporter activity Pf03810 55705 ENSG00000198700.9 IPO9 1 0 Medium Q8TED1 Probable glutathione peroxidase 8 OS=Homo sapiens OX=9606 GN=GPX8 PE=1 SV=2 0.047 1.086 5 1 1 1 209 23.9 9.35 1 1 1027519.875 1 metabolic process;response to stimulus membrane;organelle lumen antioxidant activity;catalytic activity "Pf00255, Pf00578" 493869 ENSG00000164294.13 GPX8 5 Detoxification of Reactive Oxygen Species Glutathione metabolism; Arachidonic acid metabolism; Thyroid hormone synthesis 0 Medium O60232 Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1 0.016 1.467 4 1 1 1 199 21.5 5.24 1 1 1516108.5 237781.4844 1 1 cell division protein binding Pf06677 10534 ENSG00000173465.7 SSSCA1 11 0 Medium P49257 Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2 0.014 1.487 2 1 1 1 510 57.5 6.77 1 1 494645.9063 336172.25 512914.9688 568439.25 1 1 1 1 cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane metal ion binding;protein binding Pf03388 3998 ENSG00000074695.5 LMAN1 18 Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport Protein processing in endoplasmic reticulum 0 High O43505 "Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GAT1 PE=1 SV=1" 0 4.511 4 1 1 1 415 47.1 7.2 1 1 cellular component movement;metabolic process Golgi;membrane catalytic activity;metal ion binding;protein binding Pf13896 11041 ENSG00000174684.6 B3GNT1; B4GAT1 11 Keratan sulfate biosynthesis; O-linked glycosylation Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways; Glycosaminoglycan biosynthesis - keratan sulfate 0 Medium Q9Y2G3 Probable phospholipid-transporting ATPase IF OS=Homo sapiens OX=9606 GN=ATP11B PE=1 SV=2 0.047 1.076 1 1 1 1 1177 134.1 6.96 1 1 293696.3125 1625458.875 519230.5938 1 1 1 cell organization and biogenesis;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00702, Pf08282, Pf13246, Pf13347" 23200 ENSG00000058063.15 ATP11B 3 Neutrophil degranulation; Ion transport by P-type ATPases 0 High Q6P1Q9 tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3 0 3.398 6 1 1 1 378 43.4 5.86 1 1 metabolic process catalytic activity "Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847" 55798 ENSG00000165055.15 METTL2B 7 0 High P26196 Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2 0.001 2.455 3 1 1 1 483 54.4 8.66 1 1 256372.1094 318626.4375 216309.9688 187723.5313 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf14617" 1656 ENSG00000110367.11 DDX6 11 mRNA decay by 5' to 3' exoribonuclease RNA degradation 0 High P60174 Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=3 0 2.661 5 1 1 1 286 30.8 5.92 1 1 553606.5 1 development;metabolic process cytosol;nucleus catalytic activity;protein binding Pf00121 7167 ENSG00000111669.14 TPI1 12 Gluconeogenesis; Glycolysis Carbon metabolism; Inositol phosphate metabolism; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways 0 High Q1KMD3 Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1 0.001 2.437 1 1 1 1 747 85.1 4.91 1 1 860742.6875 1 membrane;nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf08433, Pf13671" 221092 ENSG00000214753.2 HNRNPUL2 11 0 High P20036 "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" 0.003 2.127 5 1 1 1 260 29.4 5.21 1 1 301099.8125 1 regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole receptor activity;signal transducer activity "Pf00993, Pf07654" 3113 ENSG00000231389.7; ENSG00000235844.8; ENSG00000229685.8; ENSG00000224103.7; ENSG00000236177.9; ENSG00000168384.11; ENSG00000206291.10; ENSG00000228163.8 HLA-DPA1 6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1 PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains Th1 and Th2 cell differentiation; Inflammatory bowel disease (IBD); Asthma; Hematopoietic cell lineage; Allograft rejection; Epstein-Barr virus infection; Leishmaniasis; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Tuberculosis; HTLV-I infection; Toxoplasmosis; Phagosome; Autoimmune thyroid disease; Systemic lupus erythematosus; Herpes simplex infection; Viral myocarditis; Staphylococcus aureus infection; Graft-versus-host disease; Influenza A; Intestinal immune network for IgA production; Antigen processing and presentation; Rheumatoid arthritis 0 High P11172 Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1 0.001 2.272 2 1 1 1 480 52.2 7.24 1 1 97519.85938 108786.2734 215280.8594 235363.6719 1 1 1 1 metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00156, Pf00215" 7372 ENSG00000114491.13 UMPS 3 Pyrimidine biosynthesis Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 Low Q86VW2 Rho guanine nucleotide exchange factor 25 OS=Homo sapiens OX=9606 GN=ARHGEF25 PE=1 SV=2 0.056 0.963 4 1 1 1 580 63.8 6.61 1 1 regulation of biological process;response to stimulus cytoplasm;cytosol;membrane Pf00621 115557 ENSG00000240771.6 ARHGEF25 12 Gastrin-CREB signalling pathway via PKC and MAPK 0 Medium P78357 Contactin-associated protein 1 OS=Homo sapiens OX=9606 GN=CNTNAP1 PE=1 SV=1 0.036 1.19 4 1 1 1 1384 156.2 7.05 1 1 349396.7188 1 cell organization and biogenesis;regulation of biological process;response to stimulus membrane protein binding;receptor activity "Pf00054, Pf00147, Pf00754, Pf02210" 8506 ENSG00000108797.11 CNTNAP1 17 Neurofascin interactions Cell adhesion molecules (CAMs) 0 High P53985 Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3 0 3.893 3 1 1 1 500 53.9 8.66 1 1 817225 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00083, Pf07690, Pf12832" 6566 ENSG00000281917.2; ENSG00000155380.11 SLC16A1 1; CHR_HG2104_PATCH Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT); Basigin interactions; Pyruvate metabolism 0 High Q8IWR0 Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1 0.007 1.677 1 1 1 1 971 110.5 7.3 1 1 223566.25 312926.125 341870.4375 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus metal ion binding;protein binding;RNA binding "Pf00642, Pf12171, Pf13414" 29066 ENSG00000122299.11 ZC3H7A 16 0 Medium Q9UJZ1 "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" 0.027 1.333 3 1 1 1 356 38.5 7.39 1 1 10905275 11911776 8046721.5 14471303 1 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;mitochondrion protein binding Pf01145 30968 ENSG00000165283.15 STOML2 9 Processing of SMDT1 0 Low P35998 26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3 0.06 0.937 2 1 1 1 433 48.6 5.95 1 1 106005.6016 229106.875 475764.4063 546752.125 1 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00158, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 5701 ENSG00000161057.11 PSMC2 7 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 Medium Q9H3U1 Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1 0.037 1.203 2 1 1 1 944 103 6.07 1 1 cell differentiation;development;metabolic process cytoplasm;cytosol;Golgi;nucleus protein binding "Pf00515, Pf07719, Pf11701, Pf12895, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559" 55898 ENSG00000140553.17 UNC45A 15 0 Medium P06753 Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2 0.015 1.419 4 1 1 1 285 32.9 4.72 1 1 135314.3125 206041.4063 226815.1563 245706.5781 1 1 1 1 cell organization and biogenesis;cellular component movement cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf00261, Pf12718" 7170 ENSG00000143549.19 TPM3 1 Smooth Muscle Contraction; Striated Muscle Contraction Dilated cardiomyopathy; Pathways in cancer; Adrenergic signaling in cardiomyocytes; Thyroid cancer; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM) 0 High P61970 Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1 0.004 2.069 6 1 1 1 127 14.5 5.38 1 1 762081.5625 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus protein binding;transporter activity Pf02136 10204 ENSG00000102898.11 NUTF2 16 0 Medium O14733 Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2 0.042 1.131 3 1 1 1 419 47.5 9.16 1 1 174879.0625 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 5609 ENSG00000076984.17 MAP2K7 19 Uptake and function of anthrax toxins; FCERI mediated MAPK activation; Activated TLR4 signalling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Oxidative Stress Induced Senescence T cell receptor signaling pathway; TNF signaling pathway; Osteoclast differentiation; Epstein-Barr virus infection; Neurotrophin signaling pathway; MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Toll-like receptor signaling pathway; Fc epsilon RI signaling pathway; GnRH signaling pathway; Influenza A 0 Medium P19367 Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3 0.03 1.284 1 1 1 1 917 102.4 6.8 1 1 441143.375 204563.2031 1 1 cellular homeostasis;metabolic process;regulation of biological process cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00349, Pf03727" 3098 ENSG00000156515.21 HK1 10 Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency) "Insulin signaling pathway; HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Galactose metabolism; Type II diabetes mellitus; Neomycin, kanamycin and gentamicin biosynthesis; Starch and sucrose metabolism; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Carbohydrate digestion and absorption; Amino sugar and nucleotide sugar metabolism; Metabolic pathways" 0 Medium Q7Z2W4 Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3 0.049 1.021 1 1 1 1 902 101.4 8.4 1 1 229211.8125 394280.1875 366327.9063 518046.375 1 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00644 56829 ENSG00000105939.12 ZC3HAV1 7 Signaling by BRAF and RAF fusions 0 High Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2 0.001 2.444 3 1 1 1 626 72.2 7.14 1 1 192552.75 291105.6875 217170.7344 1 1 1 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00536, Pf01966, Pf07647" 25939 ENSG00000101347.8 SAMHD1 20 Nucleobase catabolism; Interferon alpha/beta signaling 0 Low Q9Y376 Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1 0.052 1 11 1 1 1 341 39.8 6.89 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;organelle lumen catalytic activity;enzyme regulator activity;protein binding Pf08569 51719 ENSG00000135932.10 CAB39 2 Energy dependent regulation of mTOR by LKB1-AMPK; Neutrophil degranulation AMPK signaling pathway; mTOR signaling pathway 0 High Q96F44 E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2 0.001 2.466 2 1 1 1 468 52.7 5.69 1 1 442659.0938 413020.8438 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227" 81559 ENSG00000154370.15 TRIM11 1 Antigen processing: Ubiquitination & Proteasome degradation 0 High P82933 "28S ribosomal protein S9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" 0.007 1.752 4 1 1 1 396 45.8 9.51 1 1 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf00380 64965 ENSG00000135972.8 MRPS9 2 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination Ribosome 0 High Q9H840 Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1 0.007 1.747 10 1 1 1 131 14.5 7.4 1 1 350924.3125 120536.2422 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus protein binding Pf11095 79760 ENSG00000142252.10 GEMIN7 19 snRNP Assembly RNA transport 0 Low Q9Y264 Angiopoietin-4 OS=Homo sapiens OX=9606 GN=ANGPT4 PE=1 SV=1 0.052 0.99 1 1 1 1 503 56.8 8.91 1 1 61373436 66018332 57158656 61782472 1 1 1 1 cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding Pf00147 51378 ENSG00000101280.7 ANGPT4 20 Tie2 Signaling HIF-1 signaling pathway; Rap1 signaling pathway; Ras signaling pathway; PI3K-Akt signaling pathway 0 High Q6NZI2 Caveolae-associated protein 1 OS=Homo sapiens OX=9606 GN=CAVIN1 PE=1 SV=1 0.007 1.777 3 1 1 1 390 43.5 5.6 1 1 274642.7188 1 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus protein binding;RNA binding Pf15237 284119 ENSG00000177469.12 PTRF; CAVIN1 17 RNA Polymerase I Transcription Termination 0 Medium Q5T9L3 Protein wntless homolog OS=Homo sapiens OX=9606 GN=WLS PE=1 SV=2 0.015 1.428 2 1 1 1 541 62.2 7.36 1 1 242417.9063 845502.25 1 1 development;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane protein binding;signal transducer activity Pf06664 79971 ENSG00000116729.13 WLS 1 WNT ligand biogenesis and trafficking 0 High Q9HBJ0 Placenta-specific protein 1 OS=Homo sapiens OX=9606 GN=PLAC1 PE=2 SV=1 0.004 2.015 6 1 1 1 212 23.6 6.71 1 1 892040.3125 1 development extracellular 10761 ENSG00000170965.9 PLAC1 X 0 Medium Q96JJ7 Protein disulfide-isomerase TMX3 OS=Homo sapiens OX=9606 GN=TMX3 PE=1 SV=2 0.036 1.189 2 1 1 1 454 51.8 4.91 1 1 231831.8125 1949491.625 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13899" 54495 ENSG00000166479.9 TMX3 18 Platelet degranulation 0 High Q16795 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA9 PE=1 SV=2" 0 2.66 3 1 1 1 377 42.5 9.8 1 1 71493.84375 184716.5781 492275.0313 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding "Pf01073, Pf01370, Pf05368" 4704 ENSG00000139180.10 NDUFA9 12 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 Medium P35606 Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2 0.013 1.499 1 1 1 1 906 102.4 5.27 1 1 260496.8281 1 transport cytoplasm;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053" 9276 ENSG00000184432.9 COPB2 3 COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport 0 Medium O95833 Chloride intracellular channel protein 3 OS=Homo sapiens OX=9606 GN=CLIC3 PE=1 SV=2 0.011 1.516 4 1 1 1 236 26.6 6.43 1 1 589797.125 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus catalytic activity;protein binding;transporter activity "Pf13409, Pf13410, Pf13417" 9022 ENSG00000169583.12 CLIC3 9 0 Medium O95104 SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3 0.018 1.373 3 1 1 1 1147 125.8 9.55 1 1 nucleus RNA binding "Pf00076, Pf04818, Pf13893, Pf14259" 57466 ENSG00000156304.14 SCAF4 21 0 Medium O14976 Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2 0.016 1.481 1 1 1 1 1311 143.1 5.73 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf00226, Pf07714, Pf10409" 2580 ENSG00000178950.16 GAK 4 Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis 0 High P02786 Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2 0 2.909 1 1 1 1 760 84.8 6.61 1 1 772692.8125 1 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endosome;extracellular;membrane protein binding;receptor activity;RNA binding;transporter activity "Pf02225, Pf04253, Pf04389" 7037 ENSG00000072274.12 TFRC 3 Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; Golgi Associated Vesicle Biogenesis Endocytosis; HIF-1 signaling pathway; Hematopoietic cell lineage; Phagosome 0 Medium P62714 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1 0.035 1.232 3 1 1 1 309 35.6 5.43 1 1 338108.7813 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;cytosol;nucleus catalytic activity;metal ion binding;protein binding Pf00149 5516 ENSG00000104695.12 PPP2CB 8 "Glycolysis; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; S33 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex" Dopaminergic synapse; Chagas disease (American trypanosomiasis); TGF-beta signaling pathway; Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; Long-term depression; mRNA surveillance pathway; Oocyte meiosis; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway 0 High O00483 Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1 0 2.711 12 1 1 1 81 9.4 9.38 1 1 629993.375 1321057.5 2842640.5 5339132 1 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf06522 4697 ENSG00000189043.9 NDUFA4 7 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High P12268 Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2 0 3.369 2 1 1 1 514 55.8 6.9 1 1 538739.1875 707117.5 412108.75 1 1 1 cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00478, Pf00571, Pf00977, Pf01070, Pf03060" 3615 ENSG00000178035.11 IMPDH2 3 Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis Purine metabolism; Metabolic pathways; Drug metabolism - other enzymes 0 High P99999 Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2 0 2.835 10 1 1 1 105 11.7 9.57 1 1 140589.1406 186723.9844 464043.7813 228088.375 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;protein binding "Pf00034, Pf13442, Pf14495" 54205 ENSG00000172115.8 CYCS 7 Transcriptional activation of mitochondrial biogenesis; Activation of caspases through apoptosome-mediated cleavage; TP53 Regulates Metabolic Genes; Respiratory electron transport; Release of apoptotic factors from the mitochondria; Formation of apoptosome; Detoxification of Reactive Oxygen Species Hepatitis B; Huntington's disease; Colorectal cancer; Pathways in cancer; Apoptosis - multiple species; Tuberculosis; Toxoplasmosis; Apoptosis; Parkinson's disease; Alzheimer's disease; p53 signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Small cell lung cancer; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS); Sulfur metabolism; Viral myocarditis; Metabolic pathways; Influenza A; Legionellosis; Platinum drug resistance 0 High O75832 26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1 0.006 1.81 4 1 1 1 226 24.4 6.1 1 1 222588.1094 178384.5938 267271.25 340396.4375 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;nucleus;proteasome protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 5716 ENSG00000101843.18 PSMD10 X Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis 0 High O43815 Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4 0 3.145 2 1 1 1 780 86.1 5.27 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;membrane protein binding "Pf00400, Pf08232" 6801 ENSG00000115808.11 STRN 2 0 Medium Q96E14 RecQ-mediated genome instability protein 2 OS=Homo sapiens OX=9606 GN=RMI2 PE=1 SV=2 0.028 1.303 5 1 1 1 147 15.9 7.9 1 1 metabolic process;regulation of biological process cytosol;nucleus DNA binding;protein binding 116028 ENSG00000175643.8 RMI2 16 G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi anemia pathway 0 High Q9BQB6 Vitamin K epoxide reductase complex subunit 1 OS=Homo sapiens OX=9606 GN=VKORC1 PE=1 SV=1 0 3.92 8 1 1 1 163 18.2 9.36 1 1 111183.75 360128.5313 1632156.875 2596573.25 1 1 1 1 coagulation;metabolic process endoplasmic reticulum;membrane catalytic activity Pf07884 79001 ENSG00000167397.14 VKORC1 16 Metabolism of vitamin K Ubiquinone and other terpenoid-quinone biosynthesis 0 High P36969 Phospholipid hydroperoxide glutathione peroxidase OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3 0 3.266 7 1 1 1 197 22.2 8.37 1 1 95457.94531 172085.3125 358135.0938 1 1 1 cell organization and biogenesis;development;metabolic process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding Pf00255 2879 ENSG00000167468.16 GPX4 19 Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids Glutathione metabolism 0 Medium Q9NZN8 CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1 0.011 1.519 1 1 1 1 540 59.7 7.66 1 1 401542.5625 113523.9609 1 1 cell differentiation;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding Pf04153 4848 ENSG00000111596.11 CNOT2 12 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA RNA degradation 0 Low Q13107 Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3 0.057 0.956 2 1 1 1 963 108.5 5.71 1 1 1465215 2147804.25 2126352.25 1588297.625 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00443, Pf06337, Pf13423, Pf14836" 7375 ENSG00000114316.12 USP4 3 Regulation of TNFR1 signaling; Ub-specific processing proteases; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling 0 High O43617 Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1 0.003 2.14 4 1 1 1 180 20.3 4.96 1 1 131848.6563 200148.2031 231897 1 1 1 cell organization and biogenesis;transport cytosol;endoplasmic reticulum;Golgi;membrane protein binding Pf04051 27095 ENSG00000054116.11 TRAPPC3 1 RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport 0 High O75223 Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1 0 2.665 7 1 1 1 188 21 5.14 1 1 463551.75 1 cell organization and biogenesis;metabolic process cytosol catalytic activity;protein binding "Pf06094, Pf13772" 79017 ENSG00000006625.17 GGCT 7 Glutathione synthesis and recycling Glutathione metabolism 0 Medium Q13561 Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4 0.018 1.366 2 1 1 1 401 44.2 5.21 1 1 757219 173338.4375 229510.6719 261457.0781 1 1 1 1 cell organization and biogenesis;cell proliferation;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;motor activity;protein binding Pf04912 10540 ENSG00000175203.15 DCTN2 12 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) Huntington's disease; Vasopressin-regulated water reabsorption 0 Low O43148 mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1 0.052 0.993 2 1 1 1 476 54.8 6.61 1 1 231234.1719 324225.7813 309731.0625 279345.1563 1 1 1 1 metabolic process nucleus catalytic activity;protein binding;RNA binding Pf03291 8731 ENSG00000101654.17 RNMT 18 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Capping mRNA surveillance pathway 0 Medium Q5SZL2 Centrosomal protein of 85 kDa-like OS=Homo sapiens OX=9606 GN=CEP85L PE=1 SV=1 0.016 1.477 1 1 1 1 805 91.8 6.33 1 1 353148.4063 1 cytoplasm;cytoskeleton "Pf02463, Pf11932, Pf13166" 387119 ENSG00000111860.13 CEP85L 6 0 Medium P28074 Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3 0.041 1.142 5 1 1 1 263 28.5 6.92 1 1 594776.375 314710.4688 429424 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;protein binding Pf00227 5693 ENSG00000100804.18 PSMB5 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 Medium P61026 Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1 0.011 1.513 6 1 1 1 200 22.5 8.38 1 1 509697.9375 742013.25 489018.2813 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;nucleotide binding;protein binding "Pf00025, Pf00071, Pf04670, Pf08477" 10890 ENSG00000084733.10 RAB10 2 Translocation of GLUT4 to the plasma membrane; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation Endocytosis; AMPK signaling pathway 0 Medium Q96ES7 SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1 0.011 1.511 3 1 1 1 293 33.2 8.1 1 1 87907.5625 498496.3125 189439.3281 183059.4688 1 1 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding Pf07039 112869 ENSG00000176476.8 CCDC101; SGF29 16 HATs acetylate histones 0 Medium Q9BTE3 Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2 0.046 1.096 3 1 1 1 642 72.9 5.87 1 1 cell division;cell organization and biogenesis;metabolic process cytosol;membrane;nucleus protein binding "Pf09739, Pf13615" 79892 ENSG00000197771.12 MCMBP 10 0 High Q96EY1 "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" 0.001 2.294 3 1 1 1 480 52.5 9.26 1 1 187701.4844 449442.2813 452009.0938 1 1 1 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 9093 ENSG00000276726.4; ENSG00000103423.13 DNAJA3 16; CHR_HSCHR16_3_CTG1 Viral carcinogenesis 0 High Q14919 Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3 0 2.614 5 1 1 1 205 22.3 5.17 1 1 947288.875 404833.5625 1 1 metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf00125, Pf00808" 10589 ENSG00000175550.7 DRAP1 11 Signaling by NODAL; Signaling by Activin 0 High Q15427 Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1 0 2.875 3 1 1 1 424 44.4 8.56 1 1 383998.9688 366097.5313 468666.8438 378440.5 1 1 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10262 ENSG00000143368.9 SF3B4 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q6NUS6 Tectonic-3 OS=Homo sapiens OX=9606 GN=TCTN3 PE=1 SV=2 0 2.579 1 1 1 1 607 66.1 8.21 1 1 406231.8438 1 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus membrane;nucleus Pf07773 26123 ENSG00000119977.20 TCTN3 10 Anchoring of the basal body to the plasma membrane 0 High Q99653 Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3 0.007 1.77 6 1 1 1 195 22.4 5.1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding;transporter activity "Pf00036, Pf12174, Pf13405, Pf13499, Pf13833" 11261 ENSG00000187446.11 CHP1 15 Hyaluronan uptake and degradation 0 Medium Q9Y2G8 DnaJ homolog subfamily C member 16 OS=Homo sapiens OX=9606 GN=DNAJC16 PE=2 SV=3 0.011 1.574 3 1 1 1 782 90.5 7.12 1 1 cellular homeostasis;regulation of biological process cytosol;membrane "Pf00085, Pf00226" 23341 ENSG00000116138.12 DNAJC16 1 0 High P43003 Excitatory amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC1A3 PE=1 SV=1 0 3.194 2 1 1 1 542 59.5 8.41 1 1 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;membrane metal ion binding;transporter activity Pf00375 6507 ENSG00000079215.13 SLC1A3 5 Defective SLC1A3 causes episodic ataxia 6 (EA6); Glutamate Neurotransmitter Release Cycle; Astrocytic Glutamate-Glutamine Uptake And Metabolism; Transport of inorganic cations/anions and amino acids/oligopeptides Glutamatergic synapse 0 Medium Q16706 Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2 0.011 1.573 1 1 1 1 1144 131.1 7.58 1 1 208375.4219 1 cell organization and biogenesis;metabolic process;regulation of biological process Golgi;membrane catalytic activity;metal ion binding "Pf01074, Pf07748, Pf09261" 4124 ENSG00000112893.9 MAN2A1 5 Intra-Golgi traffic; Reactions specific to the complex N-glycan synthesis pathway N-Glycan biosynthesis; Metabolic pathways 0 Medium Q01650 Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2 0.034 1.235 4 1 1 1 507 55 7.72 1 1 370704.875 1 cell differentiation;cellular component movement;development;metabolic process;transport cytoplasm;cytosol;membrane protein binding;transporter activity "Pf00324, Pf13520" 8140 ENSG00000103257.8 SLC7A5 16 Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane Central carbon metabolism in cancer; mTOR signaling pathway 0 Medium P57740 Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1 0.015 1.429 3 1 1 1 925 106.3 5.43 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytosol;membrane;nucleus protein binding;structural molecule activity;transporter activity Pf04121 57122 ENSG00000111581.9 NUP107 12 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High Q9Y2Q9 "28S ribosomal protein S28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" 0.006 1.873 5 1 1 1 187 20.8 9.1 1 1 339084.4063 492998 582307.25 391608.75 1 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding "Pf00575, Pf10246" 28957 ENSG00000147586.9 MRPS28 8 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 High O75608 Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1 0.01 1.594 3 1 1 1 230 24.7 6.77 1 1 356738.5 1 metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion catalytic activity;protein binding "Pf00561, Pf02230, Pf03959, Pf07859, Pf12695, Pf12697" 10434 ENSG00000120992.17 LYPLA1 8 eNOS activation Choline metabolism in cancer; Glycerophospholipid metabolism 0 High Q8NBS9 Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2 0.003 2.094 4 1 1 1 432 47.6 5.97 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;organelle lumen catalytic activity;protein binding "Pf00085, Pf13098, Pf13905" 81567 ENSG00000239264.8 TXNDC5 6 Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis Protein processing in endoplasmic reticulum 0 Medium Q5VSG8 "Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=2 SV=1" 0.035 1.229 2 1 1 1 457 51.3 6.98 1 1 219617.4844 915664.9375 1 1 Golgi;membrane catalytic activity 149175 ENSG00000185090.14 MANEAL 1 0 Medium P14373 Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 0.028 1.298 3 1 1 1 513 58.5 6.21 1 1 431699.0625 272112.2813 204945.8594 421245.375 1 1 1 1 cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endosome;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00097, Pf00622, Pf00643, Pf09074, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf15227" 5987 ENSG00000234495.7; ENSG00000229006.7; ENSG00000204713.10; ENSG00000237071.7; ENSG00000215641.8 TRIM27 6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1 Regulation of PTEN stability and activity 0 Low Q9ULN7 Paraneoplastic antigen-like protein 8B OS=Homo sapiens OX=9606 GN=PNMA8B PE=2 SV=4 0.052 0.991 5 1 1 1 635 68.6 5.45 1 1 0 High P40938 Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2 0.009 1.642 3 1 1 1 356 40.5 8.34 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding "Pf03215, Pf08542, Pf13177, Pf13401" 5983 ENSG00000133119.12 RFC3 13 Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA) DNA replication; Mismatch repair; Nucleotide excision repair 0 High Q96P63 Serpin B12 OS=Homo sapiens OX=9606 GN=SERPINB12 PE=1 SV=1 0.001 2.312 2 1 1 1 405 46.2 5.53 1 1 cell differentiation;regulation of biological process;transport cytoplasm;membrane enzyme regulator activity;protein binding Pf00079 89777 ENSG00000166634.6 SERPINB12 18 Neutrophil degranulation 0 Medium Q9Y6V7 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1 0.018 1.365 2 1 1 1 483 54.2 9.06 1 1 140366.4688 175534.375 232459.6094 1 1 1 cell organization and biogenesis;metabolic process cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf03592, Pf13863" 54555 ENSG00000105671.11 DDX49 19 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 High Q15436 Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2 0 4.48 2 1 1 1 765 86.1 7.08 1 1 340493.5 946085.5 622916.125 1 1 1 cell organization and biogenesis;transport cytoplasm;cytosol;endoplasmic reticulum;membrane metal ion binding;protein binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" 10484 ENSG00000100934.14 SEC23A 14 "Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 Medium Q10570 Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2 0.031 1.266 1 1 1 1 1443 160.8 6.4 1 1 376739.4063 256074.3125 268890.5625 279810.3438 1 1 1 1 metabolic process;transport nucleus protein binding;RNA binding "Pf03178, Pf10433" 29894 ENSG00000071894.16 CPSF1 8 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; tRNA processing in the nucleus; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs mRNA surveillance pathway 0 Medium O75683 Surfeit locus protein 6 OS=Homo sapiens OX=9606 GN=SURF6 PE=1 SV=3 0.011 1.554 7 1 1 1 361 41.4 10.64 1 1 nucleus DNA binding;protein binding;RNA binding Pf04935 6838 ENSG00000281309.1; ENSG00000148296.6 SURF6 9; CHR_HG2030_PATCH 0 Medium O75807 Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=1 0.047 1.094 2 1 1 1 674 73.4 4.61 1 1 56914312 73437584 56715784 57151724 1 1 1 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion enzyme regulator activity;protein binding Pf10488 23645 ENSG00000087074.7 PPP1R15A 19 Downregulation of TGF-beta receptor signaling Protein processing in endoplasmic reticulum 0 Medium P40926 "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" 0.042 1.113 2 1 1 1 338 35.5 8.68 1 1 573790.0625 1 metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00056, Pf01073, Pf01118, Pf02866, Pf13460" 4191 ENSG00000146701.11 MDH2 7 Gluconeogenesis; Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Metabolic pathways; Cysteine and methionine metabolism; Glyoxylate and dicarboxylate metabolism 0 High Q8NFQ8 Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1 0.009 1.634 2 1 1 1 470 51.2 4.96 1 1 283149.5625 774194.8125 1 1 cell organization and biogenesis;regulation of biological process endoplasmic reticulum;membrane;nucleus enzyme regulator activity;protein binding Pf05609 163590 ENSG00000169905.12 TOR1AIP2 1 0 Medium Q9Y421 Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2 0.031 1.264 8 1 1 1 112 13.2 9.99 1 1 273128 513735.2188 238908.6875 248364.7969 1 1 1 1 Acetyl [N-Term] cell death nucleus protein binding;RNA binding 26017 ENSG00000105058.11 FAM32A 19 0 High Q5JSZ5 Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2 0.006 1.856 0 1 1 1 2229 242.8 8.34 1 1 397127.5 490847.4375 1 1 cell differentiation protein binding;RNA binding Pf07001 84726 ENSG00000130723.18 PRRC2B 9 0 High P13489 Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2 0 4.435 5 1 1 1 461 49.9 4.82 1 1 258822.8906 1 metabolic process;regulation of biological process cytoplasm;cytosol enzyme regulator activity;protein binding 6050 ENSG00000276230.4; ENSG00000023191.16 RNH1 11; CHR_HSCHR11_1_CTG8 0 Medium P11274 Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2 0.017 1.392 1 1 1 1 1271 142.7 7.03 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00168, Pf00620, Pf00621, Pf04733, Pf09036" 613 ENSG00000186716.20 BCR 22 Signaling by cytosolic FGFR1 fusion mutants; Rho GTPase cycle Chronic myeloid leukemia; Pathways in cancer 0 High Q9P2C4 Transmembrane protein 181 OS=Homo sapiens OX=9606 GN=TMEM181 PE=1 SV=2 0.001 2.407 3 1 1 1 612 69.3 8.92 1 1 membrane Pf06664 57583 ENSG00000146433.8 TMEM181 6 0 High Q6AI12 Ankyrin repeat domain-containing protein 40 OS=Homo sapiens OX=9606 GN=ANKRD40 PE=1 SV=2 0.003 2.087 2 1 1 1 368 41.1 4.97 1 1 760091 1 protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 91369 ENSG00000154945.6 ANKRD40 17 0 High P60900 Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1 0.001 2.276 4 1 1 1 246 27.4 6.76 1 1 463790.7188 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00227, Pf10584" 5687 ENSG00000100902.10 PSMA6 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 Medium P20700 Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2 0.047 1.094 2 1 1 1 586 66.4 5.16 1 1 regulation of biological process;response to stimulus membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00932, Pf01576, Pf07888, Pf09726, Pf09731, Pf10186, Pf12128" 4001 ENSG00000113368.11 LMNB1 5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Breakdown of the nuclear lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Meiotic synapsis; Depolymerisation of the Nuclear Lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Interleukin-12 family signaling Apoptosis 0 Medium O60547 "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" 0.041 1.143 2 1 1 1 372 41.9 7.31 1 1 180240.4531 420812.5625 278253.375 354320.6563 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol catalytic activity;nucleotide binding;protein binding "Pf01370, Pf04321, Pf13460" 2762 ENSG00000112699.10 GMDS 6 GDP-fucose biosynthesis Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways 0 Medium P53634 Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2 0.042 1.113 3 1 1 1 463 51.8 6.99 1 1 184462.9219 363576.5625 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen;vacuole catalytic activity;enzyme regulator activity;protein binding "Pf00112, Pf03051, Pf08773" 1075 ENSG00000109861.15 CTSC 11 Neutrophil degranulation; MHC class II antigen presentation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport Lysosome; Apoptosis 0 Medium Q8WUA4 General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2 0.028 1.324 1 1 1 1 911 100.6 7.31 1 1 579730.375 272551.8125 338656.5 567893.0625 1 1 1 1 metabolic process nucleus DNA binding;protein binding Pf00400 2976 ENSG00000115207.13 GTF3C2 2 RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter 0 High Q13033 Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3 0 2.739 2 1 1 1 797 87.2 5.36 1 1 205671.1094 106016.6719 121909.5625 1 1 1 regulation of biological process;response to stimulus cytoplasm;Golgi;membrane;nucleus protein binding "Pf00400, Pf08232" 29966 ENSG00000196792.11 STRN3 14 0 Medium Q8IVL6 Prolyl 3-hydroxylase 3 OS=Homo sapiens OX=9606 GN=P3H3 PE=1 SV=1 0.016 1.475 3 1 1 1 736 81.8 6.32 1 1 metabolic process;regulation of biological process endoplasmic reticulum catalytic activity;metal ion binding;protein binding Pf13640 10536 ENSG00000110811.19 LEPREL2; P3H3 12 Collagen biosynthesis and modifying enzymes 0 High Q9H2U1 ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2 0 3.768 2 1 1 1 1008 114.7 7.68 1 1 1134377 484155.7813 1 1 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02562, Pf04408, Pf07717" 170506 ENSG00000174953.13 DHX36 3 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; TRAF6 mediated IRF7 activation RNA degradation 0 Medium P62308 Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1 0.02 1.342 9 1 1 1 76 8.5 8.88 1 1 697792.5625 1276529.875 841025.75 1 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding;structural molecule activity "Pf01423, Pf03122" 6637 ENSG00000143977.13 SNRPG 2 SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region Spliceosome 0 High Q8NF37 Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2 0.001 2.425 3 1 1 1 534 59.1 6.02 1 1 441960.625 1 metabolic process;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding "Pf01553, Pf13833" 79888 ENSG00000153395.9 LPCAT1 5 Synthesis of PA; Synthesis of PC; Acyl chain remodelling of PG; Neutrophil degranulation; Acyl chain remodelling of PC Ether lipid metabolism; Glycerophospholipid metabolism; Metabolic pathways 0 Medium O94776 Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1 0.037 1.201 1 1 1 1 668 75 9.66 1 1 178810.0938 123975.2266 141554.9531 150506.5625 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00249, Pf00320, Pf01426, Pf01448" 9219 ENSG00000149480.6 MTA2 11 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation 0 Medium P62699 Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1 0.016 1.404 8 1 1 1 121 13.8 7.31 1 1 83643.76563 155939.8125 422999.4688 117259.0313 1 1 1 1 transport extracellular metal ion binding Pf03226 51646 ENSG00000119801.12 YPEL5 2 Neutrophil degranulation 0 High Q96G25 Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2 0 4.198 5 1 1 1 268 29.1 7.44 1 1 433294.75 697519.9375 398170.1563 447702.3438 1 1 1 1 metabolic process;regulation of biological process nucleus protein binding Pf10232 112950 ENSG00000159479.16 MED8 1 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Herpes simplex infection 0 Medium Q8WZ42 Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4 0.046 1.098 0 1 1 1 34350 3813.7 6.35 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity "Pf00041, Pf00047, Pf00069, Pf02818, Pf07679, Pf07686, Pf07714, Pf09042, Pf10446, Pf13895, Pf13927" 7273 ENSG00000155657.26 TTN 2 Platelet degranulation ; Striated Muscle Contraction Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM) 0 Medium Q96EP5 DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1 0.02 1.351 4 1 1 1 407 43.4 8.56 1 1 388396.7813 1 cell differentiation;cell proliferation;development;regulation of biological process cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 26528 ENSG00000071626.16 DAZAP1 19 mRNA surveillance pathway 0 Medium Q96EZ8 Microspherule protein 1 OS=Homo sapiens OX=9606 GN=MCRS1 PE=1 SV=1 0.048 1.057 7 1 1 1 462 51.8 9.38 1 1 Met-loss [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;nucleus catalytic activity;enzyme regulator activity;protein binding;RNA binding "Pf00498, Pf13325" 10445 ENSG00000187778.13 MCRS1 12 HATs acetylate histones; UCH proteinases; DNA Damage Recognition in GG-NER Herpes simplex infection 0 Low Q8IW92 Beta-galactosidase-1-like protein 2 OS=Homo sapiens OX=9606 GN=GLB1L2 PE=1 SV=1 0.057 0.95 3 1 1 1 636 72 7.62 1 1 334077.4688 1 metabolic process extracellular;vacuole catalytic activity "Pf01301, Pf02449" 89944 ENSG00000149328.14 GLB1L2 11 0 High Q00059 "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" 0 2.529 6 1 1 1 246 29.1 9.72 1 1 611150.9375 1 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;mitochondrion;nucleus;organelle lumen DNA binding;protein binding;RNA binding "Pf00505, Pf09011" 7019 ENSG00000108064.10 TFAM 10 Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis Huntington's disease 0 High Q9H7D7 WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3 0.001 2.239 2 1 1 1 661 72.1 6.16 1 1 206141.9375 160811.6563 295052.375 297610 1 1 1 1 cytoplasm;cytosol protein binding "Pf00400, Pf08662" 80232 ENSG00000162923.14 WDR26 1 0 Medium Q15800 Methylsterol monooxygenase 1 OS=Homo sapiens OX=9606 GN=MSMO1 PE=1 SV=1 0.047 1.077 5 1 1 1 293 35.2 7.23 1 1 292486.75 269373.3438 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf04116 6307 ENSG00000052802.12 MSMO1 4 Cholesterol biosynthesis Steroid biosynthesis; Metabolic pathways 0 High Q96L58 "Beta-1,3-galactosyltransferase 6 OS=Homo sapiens OX=9606 GN=B3GALT6 PE=1 SV=2" 0.003 2.138 4 1 1 1 329 37.1 9.66 1 1 1679583.875 1453244.5 1247594 1 1 1 metabolic process Golgi;membrane catalytic activity Pf01762 126792 ENSG00000176022.4 B3GALT6 1 Defective B3GALT6 causes EDSP2 and SEMDJL1; A tetrasaccharide linker sequence is required for GAG synthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High Q9HB71 Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2 0.007 1.745 3 1 1 1 228 26.2 8.25 1 1 221777.25 343812.9063 284293.5 208390.4531 1 1 1 1 cell differentiation;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding "Pf04969, Pf05002, Pf09032" 27101 ENSG00000116161.17 CACYBP 1 Wnt signaling pathway 0 Medium P61163 Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1 0.042 1.127 2 1 1 1 376 42.6 6.64 1 1 169820.9844 1 regulation of biological process;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding Pf00022 10121 ENSG00000138107.12 ACTR1A 10 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) 0 High P09234 U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1 0 5.733 11 1 1 1 159 17.4 9.67 1 1 1000830.938 638330.5 1989285.625 648852.0625 1 1 1 1 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding Pf06220 6631 ENSG00000124562.9 SNRPC 6 mRNA Splicing - Major Pathway Spliceosome 0 High Q9H488 GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1 0 3.064 3 1 1 1 388 43.9 8.53 1 1 450568.625 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf10250 23509 ENSG00000101346.13 POFUT1 20 Pre-NOTCH Processing in the Endoplasmic Reticulum Other types of O-glycan biosynthesis 0 Medium Q53GQ0 Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2 0.01 1.535 3 1 1 1 312 34.3 9.32 1 1 2993838 1 cell organization and biogenesis;metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00106, Pf03435, Pf08659, Pf13460, Pf13561" 51144 ENSG00000149084.12 HSD17B12 11 Androgen biosynthesis; Synthesis of very long-chain fatty acyl-CoAs Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; Steroid hormone biosynthesis 0 Low Q8TF42 Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2 0.052 1.01 2 1 1 1 649 72.6 6.93 1 1 46899.4375 211379.2031 417373.4063 538965.375 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;protein binding "Pf00018, Pf00300, Pf00627, Pf13563, Pf14604" 84959 ENSG00000154127.9 UBASH3B 11 0 High P54198 Protein HIRA OS=Homo sapiens OX=9606 GN=HIRA PE=1 SV=2 0.005 1.918 2 1 1 1 1017 111.8 8.07 1 1 531128.875 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding "Pf00400, Pf07569, Pf09453" 7290 ENSG00000100084.14 HIRA 22 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0 High Q13724 Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5 0.007 1.789 2 1 1 1 837 91.9 8.9 1 1 291614.125 1 metabolic process endoplasmic reticulum;membrane catalytic activity Pf03200 7841 ENSG00000115275.11 MOGS 2 Defective MOGS causes MOGS-CDG (CDG-2b); N-glycan trimming in the ER and Calnexin/Calreticulin cycle N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways 0 High Q9H9A5 CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1 0.005 1.928 2 1 1 1 744 82.3 7.78 1 1 235343.75 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus protein binding Pf10046 25904 ENSG00000182973.18 CNOT10 3 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA RNA degradation 0 Medium P11717 Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3 0.016 1.472 0 1 1 1 2491 274.2 5.94 1 1 269195.1563 266107.625 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;Golgi;membrane;nucleus;vacuole catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity "Pf00040, Pf00878, Pf02157, Pf09451" 3482 ENSG00000197081.12 IGF2R 6 Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis Lysosome; Endocytosis 0 High Q5D862 Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1 0 2.83 0 1 1 1 2391 247.9 8.31 1 1 492961.8125 324650.375 714530.5625 491511.4375 1 1 1 1 transport cytoplasm;extracellular;nucleus metal ion binding;structural molecule activity 388698 ENSG00000143520.6 FLG2 1 Neutrophil degranulation 0 High Q8IV63 Inactive serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2 0 3.169 3 1 1 1 474 52.8 9.04 1 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf10571, Pf12773, Pf13240, Pf13248" 51231 ENSG00000105053.10 VRK3 19 ERKs are inactivated; Activated TLR4 signalling 0 Medium Q9NVJ2 ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1 0.016 1.464 5 1 1 1 186 21.5 8.43 1 1 830809 262014.7656 1 1 cell division;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439" 55207 ENSG00000134108.12 ARL8B 3 0 High Q8NAV1 Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1 0.006 1.874 3 1 1 1 312 37.5 9.96 1 1 678567.0625 896064.875 873915.8125 588494.375 1 1 1 1 cell organization and biogenesis;metabolic process membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf03371 84950 ENSG00000134748.12 PRPF38A 1 mRNA Splicing - Major Pathway Spliceosome 0 High Q16204 Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2 0.004 1.939 4 1 1 1 474 53.3 7.34 1 1 639126.5 1 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity "Pf04111, Pf09755" 8030 ENSG00000108091.10 CCDC6 10 Pathways in cancer; Thyroid cancer 0 High P78346 Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1 0.001 2.342 4 1 1 1 268 29.3 8.91 1 1 Met-loss+Acetyl [N-Term] metabolic process nucleus catalytic activity;protein binding;RNA binding Pf01876 10556 ENSG00000148688.13 RPP30 10 Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus Ribosome biogenesis in eukaryotes; RNA transport 0 High O94808 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Homo sapiens OX=9606 GN=GFPT2 PE=1 SV=3 0.006 1.854 3 1 1 1 682 76.9 7.37 1 1 166261.3594 327257.4375 305031.7188 377884.25 1 1 1 1 metabolic process cytosol catalytic activity;protein binding "Pf00310, Pf01380, Pf13230, Pf13522, Pf13537, Pf13580" 9945 ENSG00000131459.12 GFPT2 5 Synthesis of UDP-N-acetyl-glucosamine "Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Insulin resistance" 0 High Q9UKI8 Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2 0.005 1.916 2 1 1 1 766 86.6 8.72 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 9874 ENSG00000198586.13 TLK1 2 0 Medium O43670 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 0.013 1.502 3 1 1 1 478 50.7 9.1 1 1 808955.1875 981436.375 861609.8125 1 1 1 cell division;cell organization and biogenesis;regulation of biological process chromosome;cytoplasm;cytoskeleton;nucleus DNA binding;metal ion binding;protein binding;RNA binding 7756 ENSG00000010244.18 ZNF207 17 0 High P09467 "Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=5" 0 2.664 5 1 1 1 338 36.8 6.99 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00316, Pf00459" 2203 ENSG00000165140.9 FBP1 9 Gluconeogenesis Insulin signaling pathway; Carbon metabolism; Glucagon signaling pathway; Fructose and mannose metabolism; Pentose phosphate pathway; AMPK signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways 0 High Q5VZL5 Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1 0.006 1.853 1 1 1 1 1548 172.7 6.84 1 1 cell organization and biogenesis;development;regulation of biological process cytoplasm DNA binding;metal ion binding;protein binding "Pf06467, Pf12012" 9202 ENSG00000146463.11 ZMYM4 1 0 High Q13085 Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2 0.007 1.757 1 1 1 1 2346 265.4 6.37 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf01039, Pf02222, Pf02655, Pf02785, Pf02786, Pf07478, Pf08326, Pf13535, Pf15632" 31 ENSG00000278540.4; ENSG00000275176.4 ACACA 17; CHR_HSCHR17_7_CTG4 Fatty acyl-CoA biosynthesis; Import of palmitoyl-CoA into the mitochondrial matrix; Activation of gene expression by SREBF (SREBP); Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Biotin transport and metabolism Propanoate metabolism; Insulin signaling pathway; Pyruvate metabolism; Fatty acid biosynthesis; Glucagon signaling pathway; AMPK signaling pathway; Metabolic pathways; Fatty acid metabolism 0 Medium Q9UBV7 "Beta-1,4-galactosyltransferase 7 OS=Homo sapiens OX=9606 GN=B4GALT7 PE=1 SV=1" 0.011 1.551 3 1 1 1 327 37.4 8.98 1 1 320471.6563 1 cell organization and biogenesis;metabolic process;regulation of biological process Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf02709, Pf13733" 11285 ENSG00000027847.13 B4GALT7 5 "A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type" Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 High P01023 Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3 0.001 2.356 2 1 1 1 1474 163.2 6.46 1 1 994115.1875 997891.9375 761909.5625 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;organelle lumen enzyme regulator activity;protein binding "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 2 ENSG00000175899.14 A2M 12 Platelet degranulation ; Degradation of the extracellular matrix; Rho GTPase cycle; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation Complement and coagulation cascades 0 High Q12926 ELAV-like protein 2 OS=Homo sapiens OX=9606 GN=ELAVL2 PE=1 SV=2 0.006 1.828 3 1 1 1 359 39.5 9.13 1 1 180282.4531 321113.0625 144008.9219 134947.3906 1 1 1 1 metabolic process;regulation of biological process protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 1993 ENSG00000107105.14 ELAVL2 9 mRNA Splicing - Major Pathway 0 High Q9H813 Transmembrane protein 206 OS=Homo sapiens OX=9606 GN=TMEM206 PE=1 SV=1 0.007 1.646 3 1 1 1 350 40 8.88 1 1 281902.6563 893274.25 1 1 cell surface;membrane Pf15122 55248 ENSG00000065600.12 TMEM206 1 0 Medium Q12797 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3 0.02 1.345 1 1 1 1 758 85.8 5.01 1 1 521228.4375 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;structural molecule activity "Pf05118, Pf05279, Pf13414, Pf13428, Pf13432, Pf14559" 444 ENSG00000198363.17 ASPH 8 Ion homeostasis; Stimuli-sensing channels 0 Medium O60725 Protein-S-isoprenylcysteine O-methyltransferase OS=Homo sapiens OX=9606 GN=ICMT PE=1 SV=1 0.046 1.081 3 1 1 1 284 31.9 7.96 1 1 cell organization and biogenesis;metabolic process;transport endoplasmic reticulum;membrane catalytic activity "Pf04140, Pf04191" 23463 ENSG00000116237.15 ICMT 1 "Gamma carboxylation, hypusine formation and arylsulfatase activation" Terpenoid backbone biosynthesis 0 High O76021 Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3 0.007 1.679 2 1 1 1 490 54.9 10.13 1 1 131993.2188 368262.5 422809.125 308541.3125 1 1 1 1 cell differentiation;metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding "Pf06030, Pf11797" 26156 ENSG00000171490.12 RSL1D1 16 0 High Q86XI2 Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1 0 2.984 1 1 1 1 1143 130.9 6.87 1 1 cell division;cell organization and biogenesis;cell proliferation;metabolic process membrane;nucleus protein binding Pf12422 54892 ENSG00000146918.19 NCAPG2 7 Condensation of Prophase Chromosomes 0 High Q99943 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens OX=9606 GN=AGPAT1 PE=1 SV=2 0 3.505 7 1 1 1 283 31.7 9.38 1 1 69068.35156 440422.3438 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;protein binding Pf01553 10554 ENSG00000235758.9; ENSG00000228892.9; ENSG00000227642.9; ENSG00000206324.11; ENSG00000204310.12; ENSG00000236873.9; ENSG00000226467.9 AGPAT1 6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_COX_CTG1 Synthesis of PA; ChREBP activates metabolic gene expression Fat digestion and absorption; Phospholipase D signaling pathway; Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways 0 High O95754 Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=2 0.003 2.118 2 1 1 1 770 83.5 6.95 1 1 217553.9688 519818.5313 1 1 cell communication;cell differentiation;cellular component movement;development;regulation of biological process;response to stimulus endoplasmic reticulum;membrane protein binding "Pf01403, Pf01437" 10505 ENSG00000135622.12 SEMA4F 2 Axon guidance 0 High Q9UHR4 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Homo sapiens OX=9606 GN=BAIAP2L1 PE=1 SV=2 0 2.583 2 1 1 1 511 56.8 8.68 1 1 286432.3125 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding "Pf00018, Pf07653, Pf08397, Pf14604" 55971 ENSG00000006453.13 BAIAP2L1 7 0 Medium Q9UIX4 Potassium voltage-gated channel subfamily G member 1 OS=Homo sapiens OX=9606 GN=KCNG1 PE=1 SV=1 0.037 1.179 1 1 1 1 513 57.9 6.29 1 1 838080.875 1377217 1674625.75 980244.3125 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport membrane protein binding;transporter activity "Pf00520, Pf02214, Pf07885" 3755 ENSG00000026559.13 KCNG1 20 Voltage gated Potassium channels 0 High Q04206 Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2 0 2.608 2 1 1 1 551 60.2 5.68 1 1 89491.39844 332048.7188 1 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding Pf00554 5970 ENSG00000173039.18 RELA 11 CLEC7A/inflammasome pathway; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Regulated proteolysis of p75NTR; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 processing; PKMTs methylate histone lysines; FCERI mediated NF-kB activation; CD209 (DC-SIGN) signaling; Activation of NF-kappaB in B cells; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; NF-kB is activated and signals survival; Dectin-1 mediated noncanonical NF-kB signaling; Signalling by NGF; IkBA variant leads to EDA-ID; Senescence-Associated Secretory Phenotype (SASP) Viral carcinogenesis; Chagas disease (American trypanosomiasis); Th1 and Th2 cell differentiation; Inflammatory bowel disease (IBD); Amoebiasis; T cell receptor signaling pathway; TNF signaling pathway; NOD-like receptor signaling pathway; Osteoclast differentiation; Hepatitis B; HIF-1 signaling pathway; Pancreatic cancer; Prolactin signaling pathway; Chronic myeloid leukemia; Antifolate resistance; Epstein-Barr virus infection; Neurotrophin signaling pathway; B cell receptor signaling pathway; Leishmaniasis; Acute myeloid leukemia; MAPK signaling pathway; Pathways in cancer; Prostate cancer; NF-kappa B signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Tuberculosis; Pertussis; HTLV-I infection; Toxoplasmosis; Apoptosis; Cytosolic DNA-sensing pathway; Salmonella infection; Transcriptional misregulation in cancer; Non-alcoholic fatty liver disease (NAFLD); Cocaine addiction; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Toll-like receptor signaling pathway; Herpes simplex infection; Hepatitis C; Ras signaling pathway; RIG-I-like receptor signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway; cAMP signaling pathway; Influenza A; Legionellosis; Insulin resistance; Adipocytokine signaling pathway; Longevity regulating pathway; PI3K-Akt signaling pathway; Shigellosis 0 Medium O95782 AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3 0.037 1.207 1 1 1 1 977 107.5 7.03 1 1 290510.6875 373334.4375 226935.7656 1 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity "Pf01602, Pf02296, Pf02883, Pf13646" 160 ENSG00000196961.12 AP2A1 19 "Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 0 Low P30048 "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" 0.063 0.919 12 1 1 1 256 27.7 7.78 1 1 460660.25 1297846.625 1 1 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;mitochondrion;organelle lumen antioxidant activity;catalytic activity;enzyme regulator activity;protein binding "Pf00578, Pf08534, Pf10417, Pf13905" 10935 ENSG00000165672.6 PRDX3 10 Detoxification of Reactive Oxygen Species 0 High P50990 T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4 0.001 2.343 2 1 1 1 548 59.6 5.6 1 1 321221.5 534062.375 720835.3125 995470.0625 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;organelle lumen catalytic activity;nucleotide binding;protein binding Pf00118 10694 ENSG00000156261.12 CCT8 21 BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC 0 Medium P13807 "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" 0.037 1.2 2 1 1 1 737 83.7 6.18 1 1 254894.5625 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding "Pf00534, Pf05693, Pf13579" 2997 ENSG00000104812.14 GYS1 19 Glycogen storage disease type IV (GBE1); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1); Glycogen synthesis; Myoclonic epilepsy of Lafora Insulin signaling pathway; Glucagon signaling pathway; Starch and sucrose metabolism; AMPK signaling pathway; Metabolic pathways; Insulin resistance; PI3K-Akt signaling pathway 0 Low P25788 Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2 0.052 0.991 2 1 1 1 255 28.4 5.33 1 1 132714.6406 374957.9688 341345.5938 352336.3125 1 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus;proteasome catalytic activity;nucleotide binding;protein binding "Pf00227, Pf10584" 5684 ENSG00000100567.12 PSMA3 14 Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Proteasome 0 Medium Q9HCC0 "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" 0.037 1.199 4 1 1 1 563 61.3 7.68 1 1 cell organization and biogenesis;metabolic process cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding Pf01039 64087 ENSG00000131844.15 MCCC2 5 Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency "Metabolic pathways; Valine, leucine and isoleucine degradation" 0 High Q8IV08 5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1 0.009 1.625 2 1 1 1 490 54.7 6.47 1 1 831386.625 1 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00614, Pf13091, Pf13918" 23646 ENSG00000105223.19 PLD3 19 Synthesis of PG; Role of phospholipids in phagocytosis Ether lipid metabolism; Glycerophospholipid metabolism; Metabolic pathways 0 Low Q92793 CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3 0.052 0.983 1 1 1 1 2442 265.2 8.53 1 1 4442772 5049729.5 3432349.5 3558038.75 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;signal transducer activity "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030, Pf09770" 1387 ENSG00000005339.14 CREBBP 16 "NOTCH1 Intracellular Domain Regulates Transcription; Transcriptional regulation of white adipocyte differentiation; TRAF6 mediated IRF7 activation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Formation of the beta-catenin:TCF transactivating complex; Pre-NOTCH Transcription and Translation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; Regulation of gene expression by Hypoxia-inducible Factor; HATs acetylate histones; Notch-HLH transcription pathway; TRAF3-dependent IRF activation pathway; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; Attenuation phase; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Transcriptional activation of mitochondrial biogenesis; RUNX3 regulates NOTCH signaling; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" Viral carcinogenesis; TGF-beta signaling pathway; Hepatitis B; HIF-1 signaling pathway; FoxO signaling pathway; MicroRNAs in cancer; Epstein-Barr virus infection; Huntington's disease; Pathways in cancer; Prostate cancer; Long-term potentiation; Thyroid hormone signaling pathway; Renal cell carcinoma; Tuberculosis; Glucagon signaling pathway; HTLV-I infection; Melanogenesis; Wnt signaling pathway; Jak-STAT signaling pathway; Adherens junction; Notch signaling pathway; Herpes simplex infection; Cell cycle; cAMP signaling pathway; Influenza A 0 Medium P36897 TGF-beta receptor type-1 OS=Homo sapiens OX=9606 GN=TGFBR1 PE=1 SV=1 0.02 1.346 5 1 1 1 503 55.9 7.55 1 1 cell death;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cell surface;endosome;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00069, Pf01064, Pf07714, Pf08515" 7046 ENSG00000106799.12 TGFBR1 9 SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); SMAD2/3 MH2 Domain Mutants in Cancer; TGFBR1 KD Mutants in Cancer Chagas disease (American trypanosomiasis); Endocytosis; TGF-beta signaling pathway; Osteoclast differentiation; Hepatitis B; Pancreatic cancer; FoxO signaling pathway; Chronic myeloid leukemia; Cytokine-cytokine receptor interaction; Hippo signaling pathway; MAPK signaling pathway; Colorectal cancer; Pathways in cancer; AGE-RAGE signaling pathway in diabetic complications; HTLV-I infection; Adherens junction 0 Medium Q6PKC3 Thioredoxin domain-containing protein 11 OS=Homo sapiens OX=9606 GN=TXNDC11 PE=1 SV=2 0.045 1.102 2 1 1 1 985 110.5 6.55 1 1 221810.7969 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00085, Pf01576, Pf07926, Pf13905, Pf14662" 51061 ENSG00000153066.12 TXNDC11 16 0 High Q9Y679 Ancient ubiquitous protein 1 OS=Homo sapiens OX=9606 GN=AUP1 PE=1 SV=2 0 3.775 3 1 1 1 410 45.8 8.65 1 1 196979.8281 474072.1563 775607.625 1 1 1 0 Medium Q13242 Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1 0.016 1.476 5 1 1 1 221 25.5 8.65 1 1 293240.5313 272601.5313 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 8683 ENSG00000111786.8 SRSF9 12 Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway Spliceosome; Herpes simplex infection 0 High Q13042 Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2 0 2.663 2 1 1 1 620 71.6 5.85 1 1 682084.6875 349916.7813 1 1 cell division;cell proliferation;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus protein binding "Pf00515, Pf07719, Pf12895, Pf13374, Pf13414, Pf13424" 8881 ENSG00000130177.14 CDC16 13 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 Medium Q13620 Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4 0.047 1.084 1 1 1 1 913 103.9 7.37 1 1 387013.0938 599089.8125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf00888, Pf10557" 8450 ENSG00000158290.16 CUL4B X Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation Ubiquitin mediated proteolysis; Nucleotide excision repair 0 High Q6ZWJ1 Syntaxin-binding protein 4 OS=Homo sapiens OX=9606 GN=STXBP4 PE=1 SV=2 0.003 2.151 3 1 1 1 553 61.6 5.2 1 1 284714.2813 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm catalytic activity;protein binding "Pf00397, Pf00595, Pf04111, Pf05088, Pf05483, Pf09726, Pf10174, Pf12128, Pf14643" 252983 ENSG00000166263.13 STXBP4 17 0 High Q8N752 Casein kinase I isoform alpha-like OS=Homo sapiens OX=9606 GN=CSNK1A1L PE=2 SV=2 0 3.078 4 1 1 1 337 39.1 9.45 1 1 180507.3438 450983.2813 116064.4297 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding "Pf00069, Pf07714" 122011 ENSG00000180138.7 CSNK1A1L 13 Breast cancer; Wnt signaling pathway; Hedgehog signaling pathway 0 High P08240 Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2 0.004 2.03 1 1 1 1 638 69.8 8.95 1 1 196152 281887.25 1 1 cell organization and biogenesis;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;RNA binding "Pf00448, Pf02881, Pf03308, Pf04086" 6734 ENSG00000182934.11 SRPR; SRPRA 11 XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export 0 High Q9Y241 "HIG1 domain family member 1A, mitochondrial OS=Homo sapiens OX=9606 GN=HIGD1A PE=1 SV=1" 0.007 1.741 10 1 1 1 93 10.1 9.79 1 1 495144.5625 210230.1719 1 1 metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion Pf04588 25994 ENSG00000181061.13 HIGD1A 3 Regulation of gene expression by Hypoxia-inducible Factor 0 High Q5JS37 NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=2 SV=1 0 3.631 4 1 1 1 347 38.3 6.43 1 1 1078010.75 1 transport extracellular;organelle lumen protein binding Pf01436 387921 ENSG00000188811.13 NHLRC3 13 Neutrophil degranulation 0 Medium O94992 Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1 0.047 1.082 3 1 1 1 359 40.6 4.89 1 1 153089.75 1 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus enzyme regulator activity;protein binding;RNA binding Pf15313 10614 ENSG00000186834.3 HEXIM1 17 0 Medium P56182 Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens OX=9606 GN=RRP1 PE=1 SV=1 0.015 1.44 2 1 1 1 461 52.8 9.33 1 1 183769.1563 287791.0625 136245.4688 69925.86719 1 1 1 1 metabolic process nucleus RNA binding Pf05997 8568 ENSG00000160214.12 RRP1 21 Major pathway of rRNA processing in the nucleolus and cytosol 0 Medium P53007 "Tricarboxylate transport protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A1 PE=1 SV=2" 0.02 1.348 3 1 1 1 311 34 9.89 1 1 185192.6875 394259.2813 583008.1875 1 1 1 metabolic process;transport membrane;mitochondrion;nucleus transporter activity Pf00153 6576 ENSG00000100075.9 SLC25A1 22 Gluconeogenesis; Fatty acyl-CoA biosynthesis 0 High Q15528 Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2 0.006 1.809 7 1 1 1 200 22.2 4.68 1 1 metabolic process;regulation of biological process cytoplasm;nucleus protein binding Pf06179 6837 ENSG00000281022.2; ENSG00000148297.15 MED22 9; CHR_HG2030_PATCH Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression 0 Medium Q8TBR7 TLC domain-containing protein 3A OS=Homo sapiens OX=9606 GN=TLCD3A PE=1 SV=2 0.02 1.358 3 1 1 1 257 29.4 9.41 1 1 838080.875 1377217 1674625.75 980244.3125 1 1 1 1 membrane protein binding Pf03798 79850 ENSG00000167695.14 FAM57A 17 0 Medium Q9Y3R4 Sialidase-2 OS=Homo sapiens OX=9606 GN=NEU2 PE=1 SV=2 0.037 1.201 2 1 1 1 380 42.2 6.87 1 1 788159.1875 1 metabolic process cytoplasm;cytosol;membrane catalytic activity;protein binding Pf13088 4759 ENSG00000115488.3 NEU2 2 Glycosphingolipid metabolism; Sialic acid metabolism Sphingolipid metabolism; Other glycan degradation 0 High Q6P2C8 Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1 0.004 1.938 6 1 1 1 311 35.4 9.31 1 1 229833.3438 1 metabolic process;regulation of biological process cytosol;nucleus catalytic activity;protein binding Pf11571 9442 ENSG00000160563.13 MED27 9 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q9Y2C2 Uronyl 2-sulfotransferase OS=Homo sapiens OX=9606 GN=UST PE=2 SV=1 0.004 1.942 2 1 1 1 406 47.6 8.69 1 1 608370.375 1 metabolic process;regulation of biological process Golgi;membrane catalytic activity Pf03567 10090 ENSG00000111962.7 UST 6 Dermatan sulfate biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 Medium P57678 Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2 0.041 1.151 1 1 1 1 1058 120 6.04 1 1 cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus protein binding 50628 ENSG00000179409.10 GEMIN4 17 snRNP Assembly RNA transport 0 Medium Q92616 eIF-2-alpha kinase activator GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=6 0.047 1.092 1 1 1 1 2671 292.6 7.47 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;ribosome enzyme regulator activity;protein binding;RNA binding "Pf12074, Pf13646" 10985 GCN1L1; GCN1 12 0 Medium Q04323 UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2 0.011 1.527 6 1 1 1 297 33.3 5.25 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;nucleus;proteasome protein binding "Pf00627, Pf00789" 51035 ENSG00000162191.13 UBXN1 11 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0 High Q99873 Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3 0 3.522 4 1 1 1 371 42.4 5.35 1 1 397808.0625 274017.0625 1 1 0 High Q9BRL6 Serine/arginine-rich splicing factor 8 OS=Homo sapiens OX=9606 GN=SRSF8 PE=1 SV=1 0.006 1.898 3 1 1 1 282 32.3 11.72 1 1 metabolic process cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10929 ENSG00000263465.4 SRSF8 11 Spliceosome; Herpes simplex infection 0 Medium P20674 "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" 0.02 1.337 5 1 1 1 150 16.8 6.79 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity Pf02284 9377 ENSG00000178741.11 COX5A 15 TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 High P60468 Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2 0.001 2.453 10 1 1 1 96 10 11.56 1 1 1134556.875 2341665.5 1 1 metabolic process;transport cytosol;endoplasmic reticulum;membrane protein binding;RNA binding;transporter activity Pf03911 10952 ENSG00000106803.9 SEC61B 9 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 High P07741 Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2 0.001 2.413 4 1 1 1 180 19.6 6.02 1 1 588514.875 1 metabolic process;response to stimulus;transport cytoplasm;cytosol;extracellular;organelle lumen catalytic activity;nucleotide binding Pf00156 353 ENSG00000198931.10 APRT 16 Neutrophil degranulation; Purine salvage Purine metabolism; Metabolic pathways 0 High P60370 Keratin-associated protein 10-5 OS=Homo sapiens OX=9606 GN=KRTAP10-5 PE=1 SV=2 0 5.893 7 1 1 1 271 27.6 7.14 1 1 678528.5625 1 Met-loss+Acetyl [N-Term] cytosol protein binding 386680 KRTAP10-5 21 Keratinization 0 Medium Q8TB72 Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2 0.036 1.192 1 1 1 1 1066 114.1 7.08 1 1 185966.0781 226291.8125 315667.4375 300887.5938 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding;RNA binding Pf00806 23369 PUM2 2 Neddylation 0 High O95487 Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2 0.004 2.039 1 1 1 1 1268 137.3 6.67 1 1 170431.2031 150083.7188 1 1 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytosol;endoplasmic reticulum;membrane metal ion binding;protein binding "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" 10427 ENSG00000138802.11 SEC24B 4 "Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 Medium Q9P246 Stromal interaction molecule 2 OS=Homo sapiens OX=9606 GN=STIM2 PE=1 SV=2 0.028 1.326 2 1 1 1 746 83.9 6.76 1 1 cellular homeostasis;regulation of biological process;transport endoplasmic reticulum;membrane metal ion binding;protein binding;transporter activity "Pf00536, Pf07647" 57620 ENSG00000109689.15 STIM2 4 Calcium signaling pathway 0 High P61077 Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1 0 2.489 7 1 1 1 147 16.7 7.8 1 1 817636.25 217559.8281 1 1 cell death;metabolic process;regulation of biological process;response to stimulus cytosol;endosome;membrane catalytic activity;nucleotide binding;protein binding "Pf00179, Pf14461" 7323 ENSG00000109332.19 UBE2D3 4 "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Activated TLR4 signalling; Signaling by BMP; E3 ubiquitin ligases ubiquitinate target proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Negative regulators of DDX58/IFIH1 signaling" Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum 0 High Q9NU22 Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2 0.002 2.155 0 1 1 1 5596 632.4 5.68 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00092, Pf02367, Pf07726, Pf07728, Pf13401, Pf13671" 23195 ENSG00000112159.11 MDN1 6 Ribosome biogenesis in eukaryotes 0 High Q14728 Major facilitator superfamily domain-containing protein 10 OS=Homo sapiens OX=9606 GN=MFSD10 PE=1 SV=1 0.004 2.031 3 1 1 1 455 48.3 9.6 1 1 cell death;transport membrane transporter activity "Pf00083, Pf07690" 10227 ENSG00000109736.14 MFSD10 4 0 Medium P49760 Dual specificity protein kinase CLK2 OS=Homo sapiens OX=9606 GN=CLK2 PE=1 SV=1 0.036 1.193 2 1 1 1 499 60.1 9.66 1 1 88763.57031 187176.0938 160465.7813 140817.3281 1 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 1196 ENSG00000261893.5; ENSG00000176444.18 CLK2 1; CHR_HSCHR1_2_CTG31 0 High Q92947 "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" 0 3.034 3 1 1 1 438 48.1 8.06 1 1 335226.1875 1 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 2639 ENSG00000105607.12 GCDH 19 Lysine catabolism Fatty acid degradation; Lysine degradation; Metabolic pathways; Tryptophan metabolism 0 Medium Q02224 Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2 0.042 1.133 0 1 1 1 2701 316.2 5.64 1 1 564772.8125 145845.8125 1 1 cell division;cell organization and biogenesis;cellular component movement;development;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf00225, Pf01496, Pf02463, Pf04156, Pf05557, Pf06160, Pf08317, Pf10186, Pf12128, Pf13166" 1062 ENSG00000138778.11 CENPE 4 COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation 0 High P07858 Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3 0.009 1.623 5 1 1 1 339 37.8 6.3 1 1 767891.5625 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport extracellular;mitochondrion;organelle lumen;vacuole catalytic activity;protein binding "Pf00112, Pf08127" 1508 ENSG00000164733.20 CTSB 8 Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Neutrophil degranulation; MHC class II antigen presentation; Trafficking and processing of endosomal TLR Lysosome; NOD-like receptor signaling pathway; Renin secretion; Apoptosis; Antigen processing and presentation 0 High P31930 "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" 0 4.192 4 1 1 1 480 52.6 6.37 1 1 1539495.625 2270385 1363455.875 979086.6875 1 1 1 1 metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity "Pf00675, Pf05193, Pf08367" 7384 ENSG00000010256.10 UQCRC1 3 Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 Medium Q9BQE9 B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1 0.042 1.118 3 1 1 1 202 22.2 4.75 1 1 674079.0625 782807.1875 1 1 cell death;cell differentiation;regulation of biological process;response to stimulus protein binding Pf04714 9275 ENSG00000106635.7 BCL7B 7 0 Medium Q15054 DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2 0.031 1.251 4 1 1 1 466 51.4 9.35 1 1 84565.44531 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus cytoplasm;nucleus catalytic activity;protein binding;RNA binding "Pf08597, Pf09507" 10714 ENSG00000077514.8 POLD3 11 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Termination of translesion DNA synthesis; Recognition of DNA damage by PCNA-containing replication complex; Polymerase switching on the C-strand of the telomere; Dual incision in TC-NER; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate from the C-strand Homologous recombination; DNA replication; Purine metabolism; Mismatch repair; Base excision repair; HTLV-I infection; Nucleotide excision repair; Metabolic pathways; Pyrimidine metabolism 0 Medium Q9HDC9 Adipocyte plasma membrane-associated protein OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2 0.018 1.365 2 1 1 1 416 46.5 6.16 1 1 116917.8047 355790.1563 1261801.375 1 1 1 metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity "Pf03088, Pf08450" 57136 ENSG00000101474.11 APMAP 20 0 Medium O75694 Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1 0.028 1.315 1 1 1 1 1391 155.1 6.16 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;nucleus protein binding;structural molecule activity;transporter activity "Pf03177, Pf08801" 9631 ENSG00000113569.15 NUP155 5 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 Medium P43490 Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1 0.01 1.541 1 1 1 1 491 55.5 7.15 1 1 92654.07813 207171.0313 298603.0625 539028.0625 1 1 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;nucleus catalytic activity;protein binding Pf04095 10135 ENSG00000105835.11 NAMPT 7 "BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" NOD-like receptor signaling pathway; Nicotinate and nicotinamide metabolism; Metabolic pathways 0 High Q9UGJ1 Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1 0.006 1.894 2 1 1 1 667 76 6.65 1 1 169084.9219 1 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;endosome;membrane protein binding;structural molecule activity Pf04130 27229 ENSG00000137822.12 TUBGCP4 15 Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High Q9NWW5 Ceroid-lipofuscinosis neuronal protein 6 OS=Homo sapiens OX=9606 GN=CLN6 PE=1 SV=1 0 4.71 7 1 1 1 311 35.9 8.87 1 1 426105.0938 544821.4375 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process endoplasmic reticulum;membrane;organelle lumen protein binding Pf15156 54982 ENSG00000128973.12 CLN6 15 0 Medium Q8NBZ7 UDP-glucuronic acid decarboxylase 1 OS=Homo sapiens OX=9606 GN=UXS1 PE=1 SV=1 0.047 1.082 2 1 1 1 420 47.5 8.94 1 1 165992.25 1 cell organization and biogenesis;metabolic process cytoplasm;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf01073, Pf01370, Pf02441, Pf02719, Pf04321, Pf07993, Pf11803, Pf13460" 80146 ENSG00000115652.14 UXS1 2 Amino sugar and nucleotide sugar metabolism; Metabolic pathways 0 Medium P52789 Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2 0.049 1.036 1 1 1 1 917 102.3 6.05 1 1 78437.32813 123712.0313 166501.7969 261550.2656 1 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00349, Pf03727" 3099 ENSG00000159399.9 HK2 2 Glycolysis "Insulin signaling pathway; HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Galactose metabolism; Type II diabetes mellitus; Neomycin, kanamycin and gentamicin biosynthesis; Starch and sucrose metabolism; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Carbohydrate digestion and absorption; Amino sugar and nucleotide sugar metabolism; Metabolic pathways" 0 Medium Q9NWH9 SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2 0.016 1.45 2 1 1 1 1034 117.1 7.87 1 1 1872119.125 1 Met-loss+Acetyl [N-Term] cell death;metabolic process;regulation of biological process nucleus DNA binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 79811 ENSG00000137776.16 SLTM 15 0 Medium P55265 Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4 0.015 1.423 1 1 1 1 1226 136 8.65 1 1 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00035, Pf02137, Pf02295" 103 ENSG00000160710.15 ADAR 1 C6 deamination of adenosine; Interferon alpha/beta signaling; Formation of editosomes by ADAR proteins Cytosolic DNA-sensing pathway; Measles; Influenza A 0 Medium P06756 Integrin alpha-V OS=Homo sapiens OX=9606 GN=ITGAV PE=1 SV=2 0.028 1.305 1 1 1 1 1048 116 5.68 1 1 67627.95313 538732.125 1 1 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;membrane metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf01839, Pf08441, Pf13517" 3685 ENSG00000138448.11 ITGAV 2 Integrin cell surface interactions; Signal transduction by L1; PECAM1 interactions; Cross-presentation of particulate exogenous antigens (phagosomes); VEGFA-VEGFR2 Pathway; Molecules associated with elastic fibres; Syndecan interactions; ECM proteoglycans; Laminin interactions; Neutrophil degranulation Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Cell adhesion molecules (CAMs); Pathways in cancer; Thyroid hormone signaling pathway; Phagosome; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Hypertrophic cardiomyopathy (HCM) 0 High P29590 Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3 0.002 2.189 1 1 1 1 882 97.5 6.21 1 1 283644.6563 1 cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane;nucleus DNA binding;metal ion binding;protein binding "Pf00097, Pf00643, Pf12126, Pf13639, Pf13920, Pf14634, Pf14835" 5371 ENSG00000140464.19 PML 15 Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of RUNX1 Expression and Activity; SUMOylation of DNA damage response and repair proteins; Regulation of PTEN localization Endocytosis; Ubiquitin mediated proteolysis; Acute myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer; Herpes simplex infection; Influenza A 0 Medium P68400 Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1 0.042 1.133 2 1 1 1 391 45.1 7.74 1 1 393516.6563 480403.6563 558347.5 460842.4375 1 1 1 1 cell communication;cell death;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00069, Pf01636, Pf07714" 1457 ENSG00000101266.17 CSNK2A1 20 WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation Tight junction; Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Wnt signaling pathway; Adherens junction; Measles; Herpes simplex infection 0 Medium P17612 cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2 0.037 1.206 3 1 1 1 351 40.6 8.79 1 1 509280.6563 181820.8281 131427.1719 109281.0938 1 1 1 1 cell communication;cell organization and biogenesis;cellular homeostasis;coagulation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 5566 ENSG00000072062.13 PRKACA 19 "Triglyceride catabolism; Glycolysis; ROBO receptors bind AKAP5; Regulation of PLK1 Activity at G2/M Transition; HDL assembly; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; GLI3 is processed to GLI3R by the proteasome; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; Rap1 signalling; Degradation of GLI1 by the proteasome; PKA activation in glucagon signalling; Degradation of GLI2 by the proteasome; CREB phosphorylation through the activation of Adenylate Cyclase; Ion homeostasis; DARPP-32 events; Interleukin-3, 5 and GM-CSF signaling; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; VEGFA-VEGFR2 Pathway; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Recruitment of mitotic centrosome proteins and complexes; CD209 (DC-SIGN) signaling; PKA-mediated phosphorylation of key metabolic factors; PKA activation; RET signaling; MAPK6/MAPK4 signaling" Viral carcinogenesis; Dopaminergic synapse; Serotonergic synapse; Longevity regulating pathway - multiple species; Amoebiasis; Prion diseases; Vascular smooth muscle contraction; Glutamatergic synapse; Insulin signaling pathway; Ovarian steroidogenesis; Dilated cardiomyopathy; Bile secretion; Amphetamine addiction; Renin secretion; Epstein-Barr virus infection; Progesterone-mediated oocyte maturation; MAPK signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; Endocrine and other factor-regulated calcium reabsorption; Morphine addiction; Pathways in cancer; Long-term potentiation; Thyroid hormone signaling pathway; Insulin secretion; Gap junction; Adrenergic signaling in cardiomyocytes; Taste transduction; Glucagon signaling pathway; HTLV-I infection; Thyroid hormone synthesis; Melanogenesis; Wnt signaling pathway; Parkinson's disease; Proteoglycans in cancer; Aldosterone synthesis and secretion; Retrograde endocannabinoid signaling; Oocyte meiosis; Cocaine addiction; Vasopressin-regulated water reabsorption; Hedgehog signaling pathway; Gastric acid secretion; GABAergic synapse; Salivary secretion; Inflammatory mediator regulation of TRP channels; Vibrio cholerae infection; Alcoholism; Ras signaling pathway; Endocrine resistance; GnRH signaling pathway; Chemokine signaling pathway; cAMP signaling pathway; Estrogen signaling pathway; Regulation of lipolysis in adipocytes; Cholinergic synapse; Calcium signaling pathway; Longevity regulating pathway; Platelet activation 0 High Q9H0S4 Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1 0.003 2.14 2 1 1 1 455 50.6 9.1 1 1 280149.7188 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 51202 ENSG00000213782.7 DDX47 12 Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol 0 Medium Q08J23 RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2 0.047 1.089 1 1 1 1 767 86.4 6.77 1 1 3476245.5 3208891.75 2476998.75 2951231.25 1 1 1 1 cell division;metabolic process cytoplasm;cytoskeleton;nucleus catalytic activity;RNA binding "Pf01189, Pf13659" 54888 ENSG00000037474.14 NSUN2 5 tRNA modification in the nucleus and cytosol 0 High Q9H4A3 Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2 0 2.589 1 1 1 1 2382 250.6 6.34 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12202" 65125 ENSG00000060237.16 WNK1 12 Stimuli-sensing channels 0 High P26640 Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4 0.01 1.609 1 1 1 1 1264 140.4 7.59 1 1 150885.4688 214110.7813 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00043, Pf00133, Pf08264, Pf09334, Pf13603" 7407; 57176 ENSG00000096171.14; ENSG00000204394.12; ENSG00000226589.9 VARS; VARS2 6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 High P46020 "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform OS=Homo sapiens OX=9606 GN=PHKA1 PE=1 SV=2" 0.003 2.126 1 1 1 1 1223 137.2 6.19 1 1 metabolic process cytosol;membrane catalytic activity;protein binding Pf00723 5255 ENSG00000067177.14 PHKA1 X Glycogen breakdown (glycogenolysis) Insulin signaling pathway; Glucagon signaling pathway; Calcium signaling pathway 0 Medium Q8NAT1 "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=POMGNT2 PE=1 SV=1" 0.042 1.11 2 1 1 1 580 66.6 8.57 1 1 507916.9688 91248.40625 1 1 cellular component movement;metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding Pf04577 84892 ENSG00000144647.5 GTDC2; POMGNT2 3 O-linked glycosylation 0 Medium Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=3 0.02 1.343 1 1 1 1 2570 292.1 5.8 1 1 198696.25 174516.5313 139581.125 1 1 1 cell division;cell growth;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;protein binding "Pf00443, Pf09606, Pf13423" 8239 ENSG00000124486.12 USP9X X Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases; Amyloid fiber formation; Downregulation of SMAD2/3:SMAD4 transcriptional activity 0 High O43167 Zinc finger and BTB domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ZBTB24 PE=1 SV=2 0 3.312 2 1 1 1 697 78.2 7.61 1 1 941207.8125 1210666.25 1 1 cell differentiation;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 9841 ENSG00000112365.4 ZBTB24 6 0 High Q9NZL6 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens OX=9606 GN=RGL1 PE=1 SV=1 0.006 1.891 1 1 1 1 768 86.6 6.09 1 1 863759.4375 669265.3125 629460.5 884710.8125 1 1 1 1 regulation of biological process;response to stimulus cytosol protein binding "Pf00617, Pf00618, Pf00788" 23179 ENSG00000143344.15 RGL1 1 PPARA activates gene expression Ras signaling pathway 0 High P06733 Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2 0 3.171 3 1 1 1 434 47.1 7.39 1 1 1506616.375 1 metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00113, Pf03952, Pf13378" 2023 ENSG00000074800.13 ENO1 1 Gluconeogenesis; Glycolysis HIF-1 signaling pathway; Carbon metabolism; Glycolysis / Gluconeogenesis; RNA degradation; Biosynthesis of amino acids; Metabolic pathways 0 High Q9P2R7 "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" 0 2.95 3 1 1 1 463 50.3 7.42 1 1 424458.75 619010.5 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00549, Pf01071, Pf02222, Pf08442, Pf13535, Pf13549" 8803 ENSG00000136143.14 SUCLA2 13 Citric acid cycle (TCA cycle) Propanoate metabolism; Citrate cycle (TCA cycle); Carbon metabolism; Metabolic pathways 0 Medium Q8WUM0 Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2 0.011 1.514 1 1 1 1 1156 128.9 5.1 1 1 289213.1563 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytosol;membrane;nucleus protein binding;structural molecule activity;transporter activity "Pf03177, Pf08801" 55746 ENSG00000069248.11 NUP133 1 Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein; NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins RNA transport 0 High O60884 DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1 0.007 1.692 2 1 1 1 412 45.7 6.48 1 1 202907.875 306428.7188 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;membrane enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 10294 ENSG00000069345.11 DNAJA2 16 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 Low O75340 Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1 0.055 0.969 3 1 1 1 191 21.9 5.4 1 1 101445.9375 180241.8438 524968.0625 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00036, Pf13405, Pf13499, Pf13833" 10016 ENSG00000249915.7 PDCD6 5 0 High Q8IY17 Patatin-like phospholipase domain-containing protein 6 OS=Homo sapiens OX=9606 GN=PNPLA6 PE=1 SV=3 0 3.077 1 1 1 1 1375 150.9 7.74 1 1 261037.3438 1 0 Medium P09661 U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2 0.049 1.022 2 1 1 1 255 28.4 8.62 1 1 134153.125 149291.1875 152815.8281 175010.875 1 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex protein binding;RNA binding "Pf12799, Pf13855, Pf14580" 6627 ENSG00000131876.16 SNRPA1 15 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway Spliceosome 0 High O75448 Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1 0.007 1.787 2 1 1 1 989 110.2 6.95 1 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;receptor activity Pf11277 9862 ENSG00000008838.19 MED24 17 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High Q96II8 DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2 0.004 1.976 2 1 1 1 777 86 6.71 1 1 regulation of biological process;response to stimulus cytosol;extracellular;membrane protein binding "Pf00307, Pf12799, Pf13855" 84859 ENSG00000186001.12 LRCH3 3 0 Medium A2RU67 Protein FAM234B OS=Homo sapiens OX=9606 GN=FAM234B PE=1 SV=1 0.041 1.139 1 1 1 1 622 67 5.02 1 1 435135.3438 1 membrane Pf13360 57613 ENSG00000084444.13 KIAA1467; FAM234B 12 0 High O43795 Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3 0.003 2.119 1 1 1 1 1136 131.9 9.38 1 1 127004.9688 292114.9375 357151.0625 1 1 1 cell organization and biogenesis;cellular component movement;transport cytoplasm;endosome;membrane catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 4430 ENSG00000128641.18 MYO1B 2 0 High O95168 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Homo sapiens OX=9606 GN=NDUFB4 PE=1 SV=3 0 2.542 8 1 1 1 129 15.2 9.85 1 1 437057.8125 1 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity Pf07225 4710 ENSG00000065518.7 NDUFB4 3 Complex I biogenesis Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways 0 High Q13772 Nuclear receptor coactivator 4 OS=Homo sapiens OX=9606 GN=NCOA4 PE=1 SV=1 0.005 1.911 2 1 1 1 614 69.7 6.01 1 1 510338.0625 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport mitochondrion;nucleus;vacuole protein binding Pf12489 8031 ENSG00000266412.5 NCOA4 10 Pathways in cancer; Thyroid cancer 0 High P43686 26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2 0.002 2.193 2 1 1 1 418 47.3 5.21 1 1 266443.1875 429744.5313 317907.75 1 1 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00006, Pf00910, Pf01057, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191" 5704 ENSG00000281221.2; ENSG00000013275.7 PSMC4 19; CHR_HG2021_PATCH Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis Epstein-Barr virus infection; Proteasome 0 High Q92791 Endoplasmic reticulum protein SC65 OS=Homo sapiens OX=9606 GN=P3H4 PE=1 SV=1 0.006 1.884 3 1 1 1 437 50.3 4.77 1 1 472709.8125 525674 1 1 cell organization and biogenesis;metabolic process chromosome;endoplasmic reticulum protein binding 10609 ENSG00000141696.12 LEPREL4; P3H4 17 0 High Q16625 Occludin OS=Homo sapiens OX=9606 GN=OCLN PE=1 SV=1 0 5.361 3 1 1 1 522 59.1 6.09 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;motor activity;protein binding "Pf01284, Pf01576, Pf03962, Pf04111, Pf04156, Pf06653, Pf07303, Pf12325, Pf13536, Pf13863, Pf13962" 100506658 ENSG00000197822.10 OCLN 5 Apoptotic cleavage of cell adhesion proteins; RUNX1 regulates expression of components of tight junctions Tight junction; Pathogenic Escherichia coli infection; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Hepatitis C 0 High Q13405 "39S ribosomal protein L49, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" 0.001 2.235 7 1 1 1 166 19.2 9.45 1 1 560265.25 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome protein binding;structural molecule activity Pf05046 740 ENSG00000149792.8 MRPL49 11 Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination 0 Medium Q15417 Calponin-3 OS=Homo sapiens OX=9606 GN=CNN3 PE=1 SV=1 0.033 1.236 3 1 1 1 329 36.4 6.05 1 1 453346.4375 315705.3125 582455 132202.375 1 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process cytoskeleton;cytosol protein binding "Pf00307, Pf00402" 1266 ENSG00000117519.15 CNN3 1 0 High P51178 "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Homo sapiens OX=9606 GN=PLCD1 PE=1 SV=2" 0 3.447 2 1 1 1 756 85.6 6.7 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;protein binding;signal transducer activity "Pf00168, Pf00169, Pf00387, Pf00388, Pf09279, Pf14788" 5333 ENSG00000187091.13 PLCD1 3 Synthesis of IP3 and IP4 in the cytosol Thyroid hormone signaling pathway; Phosphatidylinositol signaling system; AGE-RAGE signaling pathway in diabetic complications; Inositol phosphate metabolism; Metabolic pathways; Calcium signaling pathway 0 High P61619 Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens OX=9606 GN=SEC61A1 PE=1 SV=2 0.006 1.846 2 1 1 1 476 52.2 8.06 1 1 365464.4063 1033211.875 1128821.25 1 1 1 cell growth;cell organization and biogenesis;response to stimulus;transport cytosol;endoplasmic reticulum;membrane protein binding "Pf00344, Pf10559" 29927 ENSG00000058262.9 SEC61A1 3 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 High P30260 Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2 0.003 2.075 1 1 1 1 824 91.8 7.02 1 1 111709.8203 478574.0313 279267.0938 275066.5313 1 1 1 1 cell proliferation;metabolic process;regulation of biological process cytoplasm;cytosol;nucleus protein binding "Pf00515, Pf05109, Pf07719, Pf12895, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559" 996 ENSG00000004897.11 CDC27 17 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 Medium Q9NQX3 Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1 0.042 1.116 1 1 1 1 736 79.7 5.43 1 1 379676.25 194740.0469 1 1 cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00994, Pf03453, Pf03454" 10243 ENSG00000171723.15 GPHN 14 Molybdenum cofactor biosynthesis Folate biosynthesis; GABAergic synapse; Metabolic pathways 0 High O00567 Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4 0.004 2.055 2 1 1 1 594 66 9.19 1 1 metabolic process cytoplasm;membrane;nucleus protein binding;RNA binding "Pf01798, Pf08060, Pf08156" 10528 ENSG00000101361.16 NOP56 20 Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis; rRNA modification in the nucleus and cytosol Ribosome biogenesis in eukaryotes 0 Medium Q9UJX3 Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=4 0.049 1.054 3 1 1 1 599 66.8 5.64 1 1 71890.82031 1 cell division;metabolic process;regulation of biological process cytosol;nucleus protein binding "Pf00515, Pf07719, Pf09674, Pf13414, Pf13432" 51434 ENSG00000196510.12 ANAPC7 12 APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP) Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High Q14444 Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2 0 2.76 2 1 1 1 709 78.3 5.25 1 1 873997.0625 352231.3438 564433.125 499189.3438 1 1 1 1 cell differentiation;regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf12287 4076 ENSG00000135387.20 CAPRIN1 11 0 Medium Q14676 Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3 0.031 1.255 1 1 1 1 2089 226.5 5.47 1 1 417303 1 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus protein binding "Pf00498, Pf05109, Pf05539" 9656 ENSG00000228575.9; ENSG00000137337.14; ENSG00000225589.9; ENSG00000224587.9; ENSG00000234012.9; ENSG00000237095.9 MDC1 6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_MCF_CTG1 G2/M DNA damage checkpoint; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins 0 High Q8N684 Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1 0.004 1.956 5 1 1 1 471 52 8 1 1 98526.00781 1 cell organization and biogenesis;metabolic process membrane;nucleus protein binding;RNA binding "Pf00076, Pf14259" 79869 ENSG00000149532.15 CPSF7 11 Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway mRNA surveillance pathway 0 High P07942 Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2 0.003 2.094 0 1 1 1 1786 197.9 4.94 1 1 115502.2969 451843.375 176708.625 1 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport extracellular;membrane;organelle lumen catalytic activity;motor activity;nucleotide binding;protein binding;signal transducer activity;structural molecule activity "Pf00015, Pf00053, Pf00055, Pf01576, Pf02841, Pf03938, Pf04156, Pf05103, Pf05335, Pf05667, Pf05698, Pf05701, Pf06428, Pf07111, Pf07767, Pf08317, Pf08647, Pf09731, Pf10174, Pf13476, Pf13514, Pf13851, Pf15346, Pf15619" 3912 ENSG00000091136.13 LAMB1 7 ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions Amoebiasis; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High O75569 Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1 0.007 1.717 4 1 1 1 313 34.4 8.41 1 1 418553.625 806174.4375 865839.3125 618759.4375 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf00035, Pf14709" 8575 ENSG00000180228.12 PRKRA 2 MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis 0 High Q9BTV4 Transmembrane protein 43 OS=Homo sapiens OX=9606 GN=TMEM43 PE=1 SV=1 0 2.822 5 1 1 1 400 44.8 8.13 1 1 69849.5625 145064.4531 626440.375 275849.25 1 1 1 1 cell organization and biogenesis endoplasmic reticulum;Golgi;membrane;nucleus;organelle lumen protein binding Pf07787 79188 ENSG00000170876.7 TMEM43 3 0 High Q7LGA3 Heparan sulfate 2-O-sulfotransferase 1 OS=Homo sapiens OX=9606 GN=HS2ST1 PE=1 SV=1 0.007 1.789 3 1 1 1 356 41.9 8.69 1 1 144090.5156 192559.5469 531432 1 1 1 metabolic process Golgi;membrane catalytic activity Pf03567 9653 ENSG00000153936.16 HS2ST1 1 HS-GAG biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 High Q09161 Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1 0.005 1.927 1 1 1 1 790 91.8 6.43 1 1 261811.8438 482088.125 449847.7188 336173.2188 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion;nucleus protein binding;RNA binding "Pf02854, Pf09088, Pf09090" 4686 ENSG00000136937.12 NCBP1 9 Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; SLBP independent Processing of Histone Pre-mRNAs; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; snRNP Assembly; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; mRNA 3'-end processing; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mRNA Capping; Regulation of expression of SLITs and ROBOs; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Formation of the Early Elongation Complex Spliceosome; mRNA surveillance pathway; RNA transport 0 High Q15011 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1 0 2.787 2 1 1 1 391 43.7 5.25 1 1 689350.75 246844.9531 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane protein binding Pf00240 9709 ENSG00000051108.14 HERPUD1 16 ATF4 activates genes Protein processing in endoplasmic reticulum 0 High Q96HR3 Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1 0 3.678 7 1 1 1 178 20.3 8.27 1 1 303770.5625 341371.5 410382.9688 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;protein binding;receptor activity Pf11315 90390 ENSG00000164758.7 MED30 8 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway Thyroid hormone signaling pathway 0 High P05109 Protein S100-A8 OS=Homo sapiens OX=9606 GN=S100A8 PE=1 SV=1 0.004 2.006 12 1 1 1 93 10.8 7.03 1 1 284820.5313 127399.3906 116316.9141 1 1 1 cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen metal ion binding;protein binding "Pf01023, Pf13499" 6279 ENSG00000143546.9 S100A8 1 Neutrophil degranulation; Metal sequestration by antimicrobial proteins; Regulation of TLR by endogenous ligand 0 High Q6ZXV5 Protein O-mannosyl-transferase TMTC3 OS=Homo sapiens OX=9606 GN=TMTC3 PE=1 SV=2 0 4.896 2 1 1 1 915 103.9 8.87 1 1 712683.6875 1 regulation of biological process;response to stimulus endoplasmic reticulum;membrane protein binding "Pf00515, Pf07719, Pf08409, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559" 160418 TMTC3 12 0 High Q86V81 THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3 0 3.503 4 1 1 1 257 26.9 11.15 1 1 642440 351209.0313 955666.6875 528843.125 1 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 10189 ALYREF 17 mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Transport of the SLBP Dependant Mature mRNA; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA Spliceosome; mRNA surveillance pathway; RNA transport; Herpes simplex infection 0 Low O15371 Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1 0.055 0.974 2 1 1 1 548 63.9 6.05 1 1 165761.0313 388811.2188 142685.3125 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf05091 8664 ENSG00000100353.17 EIF3D 22 "Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition" RNA transport 0 High Q9UGN5 Poly [ADP-ribose] polymerase 2 OS=Homo sapiens OX=9606 GN=PARP2 PE=1 SV=2 0.004 2.009 2 1 1 1 583 66.2 8.88 1 1 436431.3438 578649 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;protein binding "Pf00644, Pf02877, Pf05406" 10038 ENSG00000129484.13 PARP2 14 Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; POLB-Dependent Long Patch Base Excision Repair; HDR through MMEJ (alt-NHEJ); Dual Incision in GG-NER Base excision repair; Apoptosis 0 High Q6ZSZ5 Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4 0.007 1.778 1 1 1 1 1361 151.5 6.33 1 1 484545.5 1 0 Medium Q96H79 Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2 0.01 1.531 4 1 1 1 300 32.9 8.13 1 1 654041.6875 206474.1719 1 1 cytosol metal ion binding 92092 ENSG00000146858.7 ZC3HAV1L 7 0 Medium Q9HB40 Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1 0.017 1.392 2 1 1 1 452 50.8 5.81 1 1 466798.5625 1 metabolic process cytosol;extracellular catalytic activity Pf00450 59342 ENSG00000121064.12 SCPEP1 17 0 High P54886 Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2 0.004 1.969 1 1 1 1 795 87.2 7.12 1 1 290121.375 365214.0625 382399.375 1 1 1 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00171, Pf00696" 5832 ENSG00000059573.8 ALDH18A1 10 Amino acid synthesis and interconversion (transamination) Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism 0 Medium Q8TCS8 "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" 0.047 1.093 1 1 1 1 783 85.9 7.77 1 1 429791.8125 194667.7344 212967.2344 229434.1563 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome catalytic activity;protein binding;RNA binding "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" 87178 ENSG00000138035.14 PNPT1 2 Purine metabolism; RNA degradation; Pyrimidine metabolism 0 High O60341 Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2 0.004 2.012 2 1 1 1 852 92.8 6.52 1 1 287825.2188 143590.4844 142435.5469 1 1 1 cell organization and biogenesis;coagulation;development;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf01593, Pf04433, Pf13450, Pf13870" 23028 ENSG00000004487.15 KDM1A 1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Regulation of PTEN gene transcription; HDACs deacetylate histones; HDMs demethylate histones; Factors involved in megakaryocyte development and platelet production 0 High Q7Z4R8 UPF0669 protein C6orf120 OS=Homo sapiens OX=9606 GN=C6orf120 PE=1 SV=1 0.003 2.109 11 1 1 1 191 20.8 4.84 1 1 601174.625 1 cell death;transport extracellular;organelle lumen 387263 ENSG00000185127.6 C6orf120 6 Neutrophil degranulation 0 High O14874 "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2" 0.001 2.203 5 1 1 1 412 46.3 8.82 1 1 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf02518, Pf10436" 10295 ENSG00000103507.13 BCKDK 16 Branched-chain amino acid catabolism 0 Medium Q13444 Disintegrin and metalloproteinase domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ADAM15 PE=1 SV=4 0.015 1.423 1 1 1 1 863 92.9 6.73 1 1 385139.2813 596497.75 1 1 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;membrane catalytic activity;metal ion binding;protein binding "Pf00200, Pf00413, Pf01421, Pf01562, Pf08516, Pf13574, Pf13582, Pf13583, Pf13688" 8751 ENSG00000143537.13 ADAM15 1 Degradation of the extracellular matrix; Invadopodia formation 0 High A0A0C4DH72 Immunoglobulin kappa variable 1-6 OS=Homo sapiens OX=9606 GN=IGKV1-6 PE=3 SV=1 0.006 1.891 14 1 1 1 117 12.7 8.29 1 1 1074993.125 410419.8438 579928.375 425287.75 1 1 1 1 response to stimulus extracellular;membrane "Pf00047, Pf07679, Pf07686, Pf13927" 28943 ENSG00000282163.1; ENSG00000239855.1 IGKV1-6 2; CHR_HG2290_PATCH 0 Medium Q9UMY1 Nucleolar protein 7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2 0.036 1.197 7 1 1 1 257 29.4 9.67 1 1 mitochondrion;nucleus RNA binding Pf08157 51406 ENSG00000225921.6 NOL7 6 0 Medium Q9NZT1 Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2 0.016 1.453 12 1 1 1 146 15.9 4.44 1 1 regulation of biological process;response to stimulus;transport extracellular metal ion binding;protein binding "Pf00036, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833" 51806 ENSG00000178372.7 CALML5 10 Neutrophil degranulation Dopaminergic synapse; Phototransduction; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Renin secretion; Neurotrophin signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; Long-term potentiation; Glioma; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Pertussis; Melanogenesis; Alzheimer's disease; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; Alcoholism; Ras signaling pathway; GnRH signaling pathway; cAMP signaling pathway; Estrogen signaling pathway; Calcium signaling pathway 0 High P60411 Keratin-associated protein 10-9 OS=Homo sapiens OX=9606 GN=KRTAP10-9 PE=1 SV=2 0.006 1.851 3 1 1 1 292 30 7.43 1 1 1580455.5 1 Met-loss+Acetyl [N-Term] cytosol protein binding 386676; 386678 ENSG00000221837.5 KRTAP10-9; KRTAP10-11 21 Keratinization 0 High Q9NPA0 ER membrane protein complex subunit 7 OS=Homo sapiens OX=9606 GN=EMC7 PE=1 SV=1 0.003 2.121 5 1 1 1 242 26.5 9.25 1 1 120601.0547 380531.3438 1 1 membrane Pf09430 56851 ENSG00000134153.9 EMC7 15 0 High P42285 Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3 0 3.951 2 1 1 1 1042 117.7 6.52 1 1 69718.28906 117608.7969 1 1 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf04851, Pf08148, Pf13234" 23517 ENSG00000039123.15 SKIV2L2 5 Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway RNA degradation 0 High P60059 Protein transport protein Sec61 subunit gamma OS=Homo sapiens OX=9606 GN=SEC61G PE=1 SV=1 0 3.339 18 1 1 1 68 7.7 9.99 1 1 107886.0859 142122.9375 465028.875 162082.3594 1 1 1 1 Acetyl [N-Term] transport cytosol;endoplasmic reticulum;membrane protein binding;transporter activity Pf00584 23480 ENSG00000132432.13 SEC61G 7 ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection 0 Medium Q13136 Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1 0.042 1.111 1 1 1 1 1202 135.7 6.29 1 1 1530100.625 1274374.25 854786.8125 1428850.25 1 1 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;Golgi;nucleus catalytic activity;motor activity;protein binding;signal transducer activity "Pf00536, Pf01576, Pf02463, Pf04012, Pf04111, Pf04156, Pf05557, Pf05622, Pf06008, Pf06160, Pf06391, Pf07647, Pf09726, Pf09728, Pf09731, Pf10174, Pf12072, Pf12128, Pf12718, Pf12795, Pf13166, Pf13851, Pf14915, Pf15066, Pf15070, Pf15619" 8500 ENSG00000131626.16 PPFIA1 11 Norepinephrine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases; Glutamate Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle 0 High Q15904 V-type proton ATPase subunit S1 OS=Homo sapiens OX=9606 GN=ATP6AP1 PE=1 SV=2 0 2.976 4 1 1 1 470 52 6.14 1 1 902861.875 1 cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;transporter activity Pf05827 537 ENSG00000071553.16 ATP6AP1 X Transferrin endocytosis and recycling; Ion channel transport; Insulin receptor recycling Lysosome; Hepatitis B; Tuberculosis; Phagosome; Oxidative phosphorylation; Vibrio cholerae infection; Metabolic pathways; Epithelial cell signaling in Helicobacter pylori infection; Rheumatoid arthritis 0 High P16278 Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2 0 5.096 2 1 1 1 677 76 6.57 1 1 metabolic process;response to stimulus;transport cytoplasm;extracellular;Golgi;organelle lumen;vacuole catalytic activity;protein binding "Pf01301, Pf02449, Pf13364" 2720 GLB1 3 Sialic acid metabolism; Neutrophil degranulation; MPS IV - Morquio syndrome B; Glycosphingolipid metabolism; HS-GAG degradation; Keratan sulfate degradation Lysosome; Glycosphingolipid biosynthesis - ganglio series; Galactose metabolism; Glycosaminoglycan degradation; Sphingolipid metabolism; Other glycan degradation; Metabolic pathways 0 High Q9H944 Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1 0 2.943 5 1 1 1 212 23.2 6.87 1 1 cell differentiation;metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf08612 9477 ENSG00000124641.15 MED20 6 Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway 0 High Q8IWX8 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3 0 2.543 1 1 1 1 916 103.6 9.04 1 1 167908.375 178856.8906 275976.9375 257054.1719 1 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;membrane protein binding;RNA binding "Pf01585, Pf01805, Pf04818" 10523 ENSG00000085872.14 CHERP 19 mRNA Splicing - Major Pathway Spliceosome 0 High Q7L0Y3 tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2 0.007 1.761 6 1 1 1 403 47.3 9.36 1 1 547188.0625 349307.6563 615653 670027.75 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;protein binding;RNA binding Pf01746 54931 ENSG00000174173.6 TRMT10C 3 tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA modification in the mitochondrion 0 High Q5SW79 Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1 0.004 1.948 1 1 1 1 1584 175.2 7.11 1 1 301614.7813 694881.6875 228200.7031 325996.125 1 1 1 1 cytoplasm;cytoskeleton;cytosol;membrane protein binding "Pf00498, Pf15308" 9859 ENSG00000276725.4; ENSG00000143702.15 CEP170 1; CHR_HSCHR1_3_CTG32_1 0 Medium Q9BVG3 E3 ubiquitin-protein ligase TRIM62 OS=Homo sapiens OX=9606 GN=TRIM62 PE=1 SV=1 0.031 1.27 1 1 1 1 475 54.2 6.62 1 1 135481.6563 232446.9688 345191.6563 332943.375 1 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;extracellular;membrane catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00097, Pf00622, Pf00643, Pf01442, Pf01544, Pf01576, Pf01920, Pf03938, Pf04012, Pf04156, Pf05622, Pf06785, Pf07888, Pf10174, Pf13639, Pf13654, Pf13765, Pf13923, Pf14634, Pf14835, Pf15227, Pf15372, Pf15556" 55223 ENSG00000116525.13 TRIM62 1 Interferon gamma signaling 0 Medium Q9Y6C9 Mitochondrial carrier homolog 2 OS=Homo sapiens OX=9606 GN=MTCH2 PE=1 SV=1 0.013 1.495 8 1 1 1 303 33.3 7.97 1 1 87685.10156 1 Met-loss+Acetyl [N-Term] regulation of biological process;transport membrane;mitochondrion;nucleus Pf00153 23788 ENSG00000109919.9 MTCH2 11 0 Medium Q9ULE6 Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3 0.035 1.232 1 1 1 1 856 96.7 6.54 1 1 276277.25 1 metabolic process cytoplasm;cytosol;nucleus catalytic activity;protein binding Pf14566 27143 ENSG00000107719.8 PALD1 10 0 High P35221 Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1 0.007 1.668 2 1 1 1 906 100 6.29 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;Golgi;membrane protein binding;RNA binding;structural molecule activity Pf01044 1495 ENSG00000044115.20 CTNNA1 5 Adherens junctions interactions; CDO in myogenesis; VEGFR2 mediated vascular permeability; RHO GTPases activate IQGAPs Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Hippo signaling pathway; Endometrial cancer; Pathways in cancer; Adherens junction; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells 0 High Q92545 Transmembrane protein 131 OS=Homo sapiens OX=9606 GN=TMEM131 PE=1 SV=3 0 3.853 1 1 1 1 1883 205 8.59 1 1 586647.9375 1087647.375 1 1 membrane Pf12371 23505 ENSG00000075568.16 TMEM131 2 0 Medium Q9GZS1 DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3 0.037 1.198 2 1 1 1 419 47.2 8.94 1 1 187179.3125 264158.7188 212421.5469 1 1 1 Met-loss+Acetyl [N-Term] 0 High P49588 "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" 0.007 1.712 1 1 1 1 968 106.7 5.53 1 1 936187.1875 1215894.25 1382723.75 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;RNA binding "Pf01411, Pf02272, Pf07973" 16 ENSG00000090861.15 AARS 16 Cytosolic tRNA aminoacylation Aminoacyl-tRNA biosynthesis 0 Medium Q9UN37 Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1 0.041 1.136 2 1 1 1 437 48.9 7.8 1 1 189630.4375 233690.8594 260602.3438 1 1 1 cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus;vacuole catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf04389, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401" 27183 ENSG00000132612.15 VPS4A 16 Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 Medium Q8TCT7 Signal peptide peptidase-like 2B OS=Homo sapiens OX=9606 GN=SPPL2B PE=1 SV=2 0.027 1.333 1 1 1 1 592 64.6 8.32 1 1 263260.7813 1 metabolic process;regulation of biological process cytoskeleton;endosome;Golgi;membrane;vacuole catalytic activity;protein binding "Pf02225, Pf04258, Pf05887, Pf07223, Pf09606" 56928 ENSG00000005206.16 SPPL2B 19 Regulation of TNFR1 signaling 0 High P06703 Protein S100-A6 OS=Homo sapiens OX=9606 GN=S100A6 PE=1 SV=1 0.007 1.664 9 1 1 1 90 10.2 5.48 1 1 891340.8125 1829308.875 431862.7813 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus metal ion binding;protein binding;transporter activity Pf01023 6277 ENSG00000197956.9 S100A6 1 0 Medium Q9NTX5 Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2 0.05 1.05 3 1 1 1 307 33.7 8.21 1 1 76938.39063 134863.7188 506295.3438 67927.53125 1 1 1 1 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity Pf00378 55862 ENSG00000093144.18 ECHDC1 6 Propanoate metabolism 0 High Q9Y4K1 Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=3 0 3.59 1 1 1 1 1723 188.6 5.86 1 1 616955.8125 1 "Pf00030, Pf00652" 202 ENSG00000112297.14 AIM1; CRYBG1 6 0 High Q9Y6N1 "Cytochrome c oxidase assembly protein COX11, mitochondrial OS=Homo sapiens OX=9606 GN=COX11 PE=1 SV=3" 0.01 1.596 4 1 1 1 276 31.4 9.06 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity Pf04442 1353 ENSG00000166260.10 COX11 17 TP53 Regulates Metabolic Genes; Respiratory electron transport Oxidative phosphorylation; Metabolic pathways 0 Medium P43246 DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1 0.027 1.332 1 1 1 1 934 104.7 5.77 1 1 131587.5781 363999.375 235216.3125 202071.3281 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" 4436 ENSG00000095002.13 MSH2 2 Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of DNA Repair Genes; Defective Mismatch Repair Associated With MSH6 Colorectal cancer; Pathways in cancer; Mismatch repair; Platinum drug resistance 0 High P00403 Cytochrome c oxidase subunit 2 OS=Homo sapiens OX=9606 GN=MT-CO2 PE=1 SV=1 0.001 2.365 4 1 1 1 227 25.5 4.82 1 1 727119.6875 1 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity "Pf00116, Pf02790" 4513 ENSG00000198712.1 COX2 MT TP53 Regulates Metabolic Genes; Respiratory electron transport Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction 0 Medium Q96CW1 AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2 0.032 1.245 2 1 1 1 435 49.6 9.54 1 1 207773.7344 428194.0313 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane protein binding;transporter activity Pf00928 1173 ENSG00000161203.13 AP2M1 3 "Cargo recognition for clathrin-mediated endocytosis; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4" Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle 0 High Q15051 IQ calmodulin-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=IQCB1 PE=1 SV=1 0.004 1.994 2 1 1 1 598 68.9 9.1 1 1 148562.9375 279416.2813 298040.8438 256902.3906 1 1 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol protein binding Pf00612 9657 ENSG00000173226.16 IQCB1 3 Anchoring of the basal body to the plasma membrane 0 High P43034 Platelet-activating factor acetylhydrolase IB subunit alpha OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2 0.01 1.6 2 1 1 1 410 46.6 7.37 1 1 267818.9063 339677.6875 570217.8125 911978.375 1 1 1 1 cell communication;cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;protein binding "Pf00400, Pf08513, Pf11715" 5048 ENSG00000007168.12 PAFAH1B1 17 COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins Ether lipid metabolism; Metabolic pathways 0 Low Q15386 Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3 0.056 0.963 1 1 1 1 1083 123.8 6.71 1 1 metabolic process cytoplasm;nucleus;proteasome catalytic activity;protein binding Pf00632 9690 ENSG00000009335.17 UBE3C 7 Antigen processing: Ubiquitination & Proteasome degradation Ubiquitin mediated proteolysis 0 Medium Q9NSI6 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=BRWD1 PE=1 SV=4 0.042 1.125 0 1 1 1 2320 262.8 8.46 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding "Pf00400, Pf00439" 54014 ENSG00000185658.13 BRWD1 21 Interleukin-7 signaling; Chromatin modifying enzymes 0 High Q99755 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1 0.001 2.216 4 1 1 1 562 62.6 8.21 1 1 267049.4063 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding Pf01504 8394 ENSG00000143398.19 PIP5K1A 1 "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" Endocytosis; Phospholipase D signaling pathway; Phosphatidylinositol signaling system; Inositol phosphate metabolism; Choline metabolism in cancer; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Metabolic pathways 0 High P33992 DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5 0 2.737 2 1 1 1 734 82.2 8.37 1 1 250217.2031 762553.375 449982.2813 1 1 1 cell division;metabolic process membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 4174 ENSG00000100297.15 MCM5 22 M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins DNA replication; Cell cycle 0 High Q5JTH9 RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2 0.004 1.943 1 1 1 1 1297 143.6 8.75 1 1 216665.3125 219965.8281 188276.4688 1 1 1 membrane;nucleus RNA binding Pf08161 23223 ENSG00000052749.13 RRP12 10 0 Medium Q9UM73 ALK tyrosine kinase receptor OS=Homo sapiens OX=9606 GN=ALK PE=1 SV=3 0.035 1.214 0 1 1 1 1620 176.3 7.08 1 1 1541752.5 1 cell proliferation;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00069, Pf00629, Pf07714, Pf14531, Pf14670" 238 ENSG00000171094.16 ALK 2 Non-small cell lung cancer 0 Medium O75145 Liprin-alpha-3 OS=Homo sapiens OX=9606 GN=PPFIA3 PE=1 SV=3 0.011 1.53 1 1 1 1 1194 133.4 5.68 1 1 253750.8906 106142.2188 1 1 cellular component movement;regulation of biological process;transport cytoplasm;cytosol protein binding "Pf00536, Pf04156, Pf07647, Pf12128, Pf13851" 8541 ENSG00000177380.13 PPFIA3 19 Norepinephrine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases; Glutamate Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle 0