Protein FDR Confidence: Combined	Accession	Description	Exp. q-value: Combined	Sum PEP Score	Coverage [%]	# Peptides	# PSMs	# Unique Peptides	# AAs	MW [kDa]	calc. pI	# Peptides (by Search Engine): A2 Sequest HT (IgG)	# Peptides (by Search Engine): B2 Sequest HT (Sel1L)	# Peptides (by Search Engine): C2 Sequest HT (WT)	# Peptides (by Search Engine): D2 Sequest HT (HKO)	# PSMs (by Search Engine): A2 Sequest HT (IgG)	# PSMs (by Search Engine): B2 Sequest HT (Sel1L)	# PSMs (by Search Engine): C2 Sequest HT (WT)	# PSMs (by Search Engine): D2 Sequest HT (HKO)	"Abundance: F1: Sample, IgG"	"Abundance: F2: Sample, Sel1L"	"Abundance: F3: Sample, WT"	"Abundance: F4: Sample, HKO"	"Abundances Count: F1: Sample, IgG"	"Abundances Count: F2: Sample, Sel1L"	"Abundances Count: F3: Sample, WT"	"Abundances Count: F4: Sample, HKO"	Modifications	Biological Process	Cellular Component	Molecular Function	Pfam IDs	Entrez Gene ID	Ensembl Gene ID	Gene Symbol	Chromosome	Reactome Pathways	KEGG Pathways	# Razor Peptides
High	P14625	Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1	0	567.547	72	69	800	67	803	92.4	4.84	11	9	47	69	15	14	121	650	148700637.9	120277223.5	757421319.2	10103196506	40	35	75	98		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen	metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00183, Pf02518, Pf13589"	7184	ENSG00000166598.14	HSP90B1	12	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ATF6 (ATF6-alpha) activates chaperone genes; Interleukin-4 and 13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors	Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Estrogen signaling pathway; PI3K-Akt signaling pathway	4
High	Q9UBV2	Protein sel-1 homolog 1 OS=Homo sapiens OX=9606 GN=SEL1L PE=1 SV=3	0	634.883	72	41	781	41	794	88.7	5.39		1	38	40		2	304	475	19026674.39	35122636.26	3165379634	5438883573	10	16	74	73		metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane	protein binding	"Pf00040, Pf08238"	6400	ENSG00000071537.13	SEL1L	14	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; Pre-NOTCH Processing in Golgi; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis	Protein processing in endoplasmic reticulum	0
High	Q96PY6	Serine/threonine-protein kinase Nek1 OS=Homo sapiens OX=9606 GN=NEK1 PE=1 SV=2	0	446.259	60	76	565	76	1258	142.7	5.94		70	63	68		206	180	179	1865647.596	1197378814	953271655.4	1242384695	15	92	86	90		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00069, Pf07714, Pf14531"	4750	ENSG00000137601.16	NEK1	4			0
High	O75592	E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4	0	545.852	34	131	536	131	4678	513.3	7.02	3	101	112	117	3	152	188	193	25522907.91	224734294.5	321288216.6	337726875.3	46	123	126	125												0
High	Q13438	Protein OS-9 OS=Homo sapiens OX=9606 GN=OS9 PE=1 SV=1	0	529.001	74	62	530	62	667	75.5	4.87			56	61			190	340	1975394.145	5242087.039	1692261615	4925804536	9	8	72	81		metabolic process;response to stimulus;transport	endoplasmic reticulum;membrane;organelle lumen	protein binding	Pf07915	10956	ENSG00000135506.15	OS9	12	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis	Protein processing in endoplasmic reticulum	0
High	P04264	"Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6"	0	281.661	69	43	458	41	644	66	8.12	39	40	35	35	134	118	100	106	748091118.3	718568296.5	579923310.7	658519573.8	58	58	55	55		cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoskeleton;cytosol;extracellular;membrane;nucleus	catalytic activity;motor activity;protein binding;receptor activity;structural molecule activity	"Pf00038, Pf01576, Pf05103, Pf05957, Pf12128, Pf13166, Pf13514"	3848	ENSG00000167768.4	KRT1	12	Formation of the cornified envelope; Neutrophil degranulation		3
High	P27694	Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2	0	331.982	72	42	386	42	616	68.1	7.21	1	39	40	37	1	135	140	110	3103612.5	1428334353	1269292878	796502407.5	11	56	57	53	Met-loss [N-Term]; Acetyl [N-Term]	cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	nucleus	DNA binding;metal ion binding;protein binding	"Pf01336, Pf01485, Pf04057, Pf08646"	6117	ENSG00000132383.11	RPA1	17	Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand; SUMOylation of DNA damage response and repair proteins	Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair	0
High	P13645	"Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6"	0	249.698	55	32	346	28	584	58.8	5.21	27	29	29	31	80	94	81	91	386776571.1	618993732.8	417060651.3	561597229.1	42	43	40	40		cell death;cell differentiation;metabolic process	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	structural molecule activity	"Pf00038, Pf04111"	3858	ENSG00000186395.7	KRT10	17	Formation of the cornified envelope	Staphylococcus aureus infection	5
High	P11021	Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2	0	257.355	60	44	340	42	654	72.3	5.16	26	38	24	43	46	101	41	152	112390358.8	331626732	118968233.5	1203022358	45	46	41	49		cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00012, Pf01968, Pf06723"	3309	ENSG00000044574.7	HSPA5	9	"Platelet degranulation ; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response; IRE1alpha activates chaperones"	Prion diseases; Protein export; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Antigen processing and presentation	2
High	P35527	"Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3"	0	278.34	67	33	329	32	623	62	5.24	28	29	32	26	92	84	82	71	362468642.2	285582989.9	295261574.1	295409848.3	45	43	44	43		cell death;cell organization and biogenesis	cytosol;membrane;nucleus	structural molecule activity	"Pf00038, Pf13166"	3857	ENSG00000171403.9	KRT9	17	Formation of the cornified envelope		1
High	Q96DZ1	Endoplasmic reticulum lectin 1 OS=Homo sapiens OX=9606 GN=ERLEC1 PE=1 SV=1	0	328.609	82	35	317	35	483	54.8	6.28			32	35			158	159	1559399.09	6779208.08	1741448400	1866291419	3	5	45	45		metabolic process;transport	endoplasmic reticulum;organelle lumen	protein binding	"Pf07915, Pf13015"	27248	ENSG00000068912.13	ERLEC1	2	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis	Protein processing in endoplasmic reticulum	0
High	Q9H792	Inactive tyrosine-protein kinase PEAK1 OS=Homo sapiens OX=9606 GN=PEAK1 PE=1 SV=4	0	341.439	59	75	286	75	1746	193	6.89		72	60	31		150	99	37	4912404.352	333966878.7	191337441.4	67242943.3	7	71	66	56	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;metabolic process	cytoplasm;cytoskeleton	catalytic activity;nucleotide binding;protein binding	Pf00069	79834	ENSG00000173517.10	PEAK1	15			0
High	P35637	RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1	0	145.871	25	15	282	13	526	53.4	9.36	13	14	14	13	66	78	72	66	407522831.8	424672134.3	381654658.8	424805100.3	18	18	18	18		metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	DNA binding;metal ion binding;protein binding;RNA binding	"Pf00076, Pf00641, Pf13893, Pf14259"	2521	ENSG00000089280.18	FUS	16	mRNA Splicing - Major Pathway	Transcriptional misregulation in cancer	2
High	P19474	E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1	0	166.528	59	32	268	32	475	54.1	6.38	20	25	29	31	37	52	95	84	80657426.51	166545874.2	493789312.8	523224843.3	33	30	36	37		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus;vacuole	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	"Pf00097, Pf00622, Pf00643, Pf11789, Pf12128, Pf12678, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227"	6737	ENSG00000132109.9	TRIM21	11	STING mediated induction of host immune responses; Antigen processing: Ubiquitination & Proteasome degradation; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA	Systemic lupus erythematosus	0
High	P35908	"Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2"	0	197.007	67	38	258	29	639	65.4	8	30	34	31	31	57	85	54	62	155922998.2	230930612.7	126196487.7	180460974.8	41	44	38	38	Met-loss+Acetyl [N-Term]	cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process	cytoskeleton;cytosol;membrane;nucleus	protein binding;structural molecule activity	"Pf00038, Pf08614, Pf12128, Pf13166"	3849	ENSG00000172867.3	KRT2	12	Formation of the cornified envelope		8
High	P11142	Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1	0	177.638	47	32	254	26	646	70.9	5.52	23	27	26	31	48	68	64	74	75701530.44	135201444.2	129439665.2	162380923.2	29	30	28	32		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen;spliceosomal complex	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00012, Pf02463, Pf06723"	3312	ENSG00000109971.13	HSPA8	11	"Protein methylation; Clathrin-mediated endocytosis; Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; Lysosome Vesicle Biogenesis; CHL1 interactions; AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; mRNA Splicing - Major Pathway; Interleukin-4 and 13 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR)"	Endocytosis; Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation	0
High	Q9UPQ9	Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4	0	252.834	47	55	251	55	1833	193.9	6.76	45	39	37	42	75	59	50	67	114477836.9	89318632.71	70294632.13	113163425.6	54	52	53	48		regulation of biological process;response to stimulus	cytoplasm;cytosol	protein binding;RNA binding	"Pf10427, Pf13893"	23112	ENSG00000100354.20	TNRC6B	22	Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence		0
High	P0DMV9	Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1	0	205.836	55	33	249	29	641	70	5.66	27	24	29	30	58	50	70	71	203611549.6	181176496.9	334903237.9	367123917.4	38	37	38	37		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus	catalytic activity;nucleotide binding;protein binding;receptor activity;RNA binding	"Pf00012, Pf06723"	3304; 3303	ENSG00000232804.5; ENSG00000234475.5; ENSG00000231555.4; ENSG00000235941.5; ENSG00000204389.9; ENSG00000204388.6; ENSG00000212866.6; ENSG00000237724.5; ENSG00000224501.5	HSPA1B; HSPA1A	6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1	AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; Viral RNP Complexes in the Host Cell Nucleus; HSP90 chaperone cycle for steroid hormone receptors (SHR)	Endocytosis; Longevity regulating pathway - multiple species; Prion diseases; Epstein-Barr virus infection; Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Toxoplasmosis; Measles; Influenza A; Estrogen signaling pathway; Legionellosis; Antigen processing and presentation	4
High	P22626	Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2	0	172.333	75	29	223	25	353	37.4	8.95	26	28	25	25	55	72	44	52	263446963.1	574425423.7	271304992.7	316239601.3	32	33	32	32		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	3181	ENSG00000122566.20	HNRNPA2B1	7	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway		4
High	P27708	CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3	0	226.179	37	62	214	62	2225	242.8	6.46	16	40	48	42	22	55	75	62	23945487.43	84699334.27	133590191.9	120568538.9	42	56	57	55	Met-loss+Acetyl [N-Term]	metabolic process	cytoplasm;cytosol;membrane;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00117, Pf00185, Pf00289, Pf00988, Pf01979, Pf02142, Pf02222, Pf02729, Pf02786, Pf02787, Pf07478, Pf07722, Pf13147, Pf13535, Pf13594, Pf15632"	790	ENSG00000084774.13	CAD	2	Pyrimidine biosynthesis	"Alanine, aspartate and glutamate metabolism; Metabolic pathways; Pyrimidine metabolism"	0
High	Q99570	Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3	0	228.206	41	45	195	45	1358	153	7.17		43	31	28		96	54	45	7986570.465	250240124.8	88825203.02	86949596.53	5	42	39	37		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoskeleton;cytosol;endosome;membrane;vacuole	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf00400"	30849	ENSG00000196455.7	PIK3R4	3	PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy	Autophagy	0
High	P15927	Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1	0	167.993	88	14	191	14	270	29.2	6.15		12	13	10		76	77	38	2964929.109	653050027.9	589258192.6	380430167.9	6	21	24	23	Acetyl [N-Term]	cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	DNA binding;protein binding	Pf08784	6118	ENSG00000117748.9	RPA2	1	Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand	Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair	0
High	Q13428	Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3	0	183.091	32	42	189	42	1488	152	9.04	1	35	36	39	1	57	66	65	30209506.66	172457501.5	225321067.5	221511670.2	10	45	47	46		cell organization and biogenesis;regulation of biological process;transport	cytosol;nucleus	protein binding;RNA binding;transporter activity	Pf03546	6949	ENSG00000070814.17	TCOF1	5		Ribosome biogenesis in eukaryotes	0
High	P07437	Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2	0	162.652	72	25	189	4	444	49.6	4.89	17	17	21	25	24	34	53	78	50984456.97	107802758.6	134215899.7	265224750	27	29	28	31		cell division;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;extracellular;membrane;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;structural molecule activity	"Pf00091, Pf03953, Pf10644"	203068	ENSG00000232575.10; ENSG00000196230.12; ENSG00000227739.10; ENSG00000224156.10; ENSG00000235067.10; ENSG00000229684.10; ENSG00000183311.16; ENSG00000232421.10	TUBB	6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1	Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes	Pathogenic Escherichia coli infection; Gap junction; Phagosome	26
High	P68371	Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1	0	143.478	68	24	178	1	445	49.8	4.89	17	16	19	24	22	36	46	74	3880973.438	7274839.906	12278524.75	27615999	3	3	4	4		cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity	"Pf00091, Pf03953, Pf10644"	10383	ENSG00000188229.5	TUBB4B	9	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome	3
High	P68363	Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1	0	132.225	53	20	174	3	451	50.1	5.06	16	16	19	20	21	41	47	65	34389128.61	87390425.18	114675566.5	212197400.8	23	23	23	23		cell division;cell organization and biogenesis;response to stimulus;transport	cytoplasm;cytoskeleton;membrane	catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity	"Pf00091, Pf03953"	10376	ENSG00000123416.15	TUBA1B	12	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis	21
High	Q96F24	Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1	0	149.204	69	21	172	21	287	32.4	5.87		20	20	19		90	39	43	28158304.46	541792759.1	161823018.5	161511369.2	2	22	23	22	Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus;vacuole	DNA binding;protein binding	"Pf02183, Pf04212, Pf04977, Pf08961"	29982	ENSG00000148572.15	NRBF2	10	Nuclear Receptor transcription pathway		0
High	P35244	Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1	0	127.597	88	8	171	8	121	13.6	5.08	2	8	8	8	2	66	62	41	3937918.256	298761452.2	336005070.3	223057860	7	18	17	17	Met-loss [N-Term]; Met-loss+Acetyl [N-Term]; Acetyl [N-Term]	cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	nucleus	DNA binding;protein binding	Pf08661	6119	ENSG00000106399.11	RPA3	7	Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand	Homologous recombination; DNA replication; Fanconi anemia pathway; Mismatch repair; Nucleotide excision repair	0
High	Q13616	Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2	0	181.311	52	38	171	38	776	89.6	8		31	31	36		57	54	60	1031148.047	97406179.63	113560127.8	140748940.8	8	36	36	38		cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytosol	catalytic activity;protein binding	"Pf00888, Pf10557"	8454	ENSG00000055130.15	CUL1	7	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling	TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Herpes simplex infection; Cell cycle	0
High	Q9UQ35	Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2	0	129.817	17	34	166	34	2752	299.4	12.06	23	23	30	20	39	38	51	38	84439291.11	100039120.5	107006574.8	102850926.2	31	31	30	31		metabolic process	nucleus;spliceosomal complex	nucleotide binding;protein binding;RNA binding		23524	ENSG00000167978.16	SRRM2	16	mRNA Splicing - Major Pathway		0
High	P09651	Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5	0	161.151	59	24	162	20	372	38.7	9.13	18	23	14	18	42	58	29	33	83088026.81	171857912.5	94324285.03	89877852.75	19	22	20	21		cell communication;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	3178	ENSG00000135486.17	HNRNPA1	12	mRNA Splicing - Major Pathway; FGFR2 alternative splicing	Spliceosome	0
High	P38646	"Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2"	0	142.972	48	33	162	32	679	73.6	6.16	23	21	31	25	32	39	53	38	67551727.79	94951900.45	117642936.9	116475908.1	31	32	32	31		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;mitochondrion;nucleus;organelle lumen	nucleotide binding;protein binding;RNA binding	"Pf00012, Pf06723"	3313	ENSG00000113013.12	HSPA9	5	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Interleukin-12 family signaling; Cristae formation; Metabolism of proteins	Tuberculosis; RNA degradation	1
High	Q9BQE3	Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1	0	119.491	50	19	162	2	449	49.9	5.1	14	15	18	19	19	41	44	58		597310.4688	1721688.813	3204874.625		2	2	2		cell division;cell organization and biogenesis;transport	cytoplasm;cytoskeleton;nucleus	catalytic activity;nucleotide binding;protein binding;structural molecule activity	"Pf00091, Pf03953"	84790	ENSG00000167553.15	TUBA1C	12	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome; Apoptosis	0
High	O14497	AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3	0	171.965	28	42	155	41	2285	241.9	6.7	32	27	22	31	49	33	27	46	37412051.13	31268566.16	29123265.78	44028175.59	36	33	33	33		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	nucleus	DNA binding;protein binding	"Pf01388, Pf12031"	8289	ENSG00000117713.18	ARID1A	1	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		1
High	P04350	Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2	0	129.684	69	23	153	2	444	49.6	4.88	13	12	17	23	15	30	43	65	1285797.398	381957.3438	2592198.406	5123439.281	3	2	3	3		cell organization and biogenesis;regulation of biological process	cytoplasm;cytoskeleton;cytosol;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity	"Pf00091, Pf03953, Pf10644"	10382	ENSG00000104833.11	TUBB4A	19	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome	0
High	Q9UJV9	Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2	0	109.008	56	31	150	31	622	69.8	6.84	26	18	19	25	50	30	30	40	60212308.22	53172413.14	52254777.86	72283635.94	30	28	28	30		cell death;cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;spliceosomal complex	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf13307"	51428	ENSG00000183258.11	DDX41	5	IRF3-mediated induction of type I IFN; Regulation of innate immune responses to cytosolic DNA		0
High	Q9BVA1	Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1	0	121.855	49	20	150	1	445	49.9	4.89	14	15	17	20	18	28	42	62		583614.5625	500963.9688	979288.1875		1	1	1		cell organization and biogenesis;cellular component movement;regulation of biological process	cytoplasm;cytoskeleton;nucleus	catalytic activity;nucleotide binding;protein binding;structural molecule activity	"Pf00091, Pf03953, Pf10644"	347733	ENSG00000137285.9	TUBB2B	6	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome	0
High	Q13885	Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1	0	119.418	49	20	148	1	445	49.9	4.89	14	15	16	19	18	28	41	61	178388.0625	1247187.594	986705	2556890.75	1	2	2	2		cell organization and biogenesis	cytoplasm;cytoskeleton;nucleus	catalytic activity;nucleotide binding;protein binding;structural molecule activity	"Pf00091, Pf03953, Pf10644"	7280	ENSG00000137267.5	TUBB2A	6	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome	1
High	P62258	14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1	0	103.743	67	23	145	20	255	29.2	4.74	1	20	20	21	1	51	46	47	7205855.027	230245386.3	177718085.3	210708840.8	13	23	24	24	Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus	protein binding;RNA binding	Pf00244	7531	ENSG00000108953.16; ENSG00000274474.3	YWHAE	17; CHR_HSCHR17_2_CTG2	Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; NADE modulates death signalling; Translocation of GLUT4 to the plasma membrane; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by Hippo; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of HSF1-mediated heat shock response; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; RAB GEFs exchange GTP for GDP on RABs; HSF1 activation; TP53 Regulates Metabolic Genes; Signalling by NGF; RHO GTPases activate PKNs	Viral carcinogenesis; Epstein-Barr virus infection; Neurotrophin signaling pathway; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway	3
High	Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1	0	154.616	42	34	145	34	887	101.5	6.81		33	22	27		70	38	37	55969.75781	179332304.4	64874318.35	75067322.27	1	35	33	30		cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;endosome;membrane;vacuole	catalytic activity;nucleotide binding;protein binding	"Pf00454, Pf00613, Pf00792"	5289	ENSG00000078142.12	PIK3C3	18	PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy	Phosphatidylinositol signaling system; Tuberculosis; Inositol phosphate metabolism; Phagosome; Autophagy; Metabolic pathways	0
High	O95714	E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2	0	197.17	17	65	144	65	4834	526.9	6.28	9	56	46	14	9	70	51	14	13434868.03	64786342.84	47644832	35324181.08	39	57	54	44	Met-loss [N-Term]	metabolic process;response to stimulus;transport	cytoplasm;cytoskeleton;membrane;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00173, Pf00415, Pf00569, Pf00632, Pf03256, Pf06701, Pf11515, Pf13540"	8924	ENSG00000128731.15	HERC2	15	G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Antigen processing: Ubiquitination & Proteasome degradation; SUMOylation of DNA damage response and repair proteins	Ubiquitin mediated proteolysis	0
High	P68104	Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1	0	116.642	56	19	137	19	462	50.1	9.01	14	13	15	17	31	26	34	46	95672605.25	138134005.2	185468645.8	264471664.1	15	18	19	20		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf03143, Pf03144"	1915	ENSG00000156508.17	EEF1A1	6	Peptide chain elongation; Protein methylation; Neutrophil degranulation; HSF1 activation	RNA transport; Legionellosis	0
High	P22061	Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4	0	98.41	66	13	134	13	227	24.6	7.21	13	13	12	13	34	34	33	33	185172371.2	95743238.33	122914836	144943148.8	17	18	18	18		metabolic process	cytoplasm;cytosol	catalytic activity;protein binding	"Pf01135, Pf01209, Pf05175, Pf06325, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847"	5110		PCMT1	6	Protein repair		0
High	Q00839	Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6	0	110.123	30	22	132	21	825	90.5	6	14	18	20	20	18	40	37	37	47264543.25	100035590.3	88080549.78	73510326.88	24	24	24	24		cell differentiation;metabolic process;regulation of biological process;response to stimulus	cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex	DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00622, Pf13671"	3192	ENSG00000153187.18	HNRNPU	1	mRNA Splicing - Major Pathway	Spliceosome	0
High	P31943	Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4	0	111.27	53	16	129	9	449	49.2	6.3	16	15	13	12	32	38	29	30	85615536.78	83805469.16	73562532.59	89574420.72	20	20	17	17	Met-loss+Acetyl [N-Term]; Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus	cytosol;membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf08080, Pf14259"	3187	ENSG00000169045.17; ENSG00000284254.1	HNRNPH1	5; CHR_HG30_PATCH	mRNA Splicing - Major Pathway; FGFR2 alternative splicing		11
High	O43822	Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1	0	80.445	63	15	129	15	256	28.3	7.34		14	13	14		47	38	44	458094.5488	482121602.2	322042313.5	418367802.4	3	15	15	16		cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;membrane;mitochondrion	protein binding	"Pf12799, Pf13855, Pf14580"	755	ENSG00000160226.15	C21orf2	21			0
High	P52272	Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3	0	106.168	48	33	125	33	730	77.5	8.7	22	21	26	24	31	27	37	30	44851024.13	34966389.08	66883239.84	58624577.34	29	25	29	28	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus	membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf11532, Pf11608, Pf13893, Pf14259"	4670	ENSG00000099783.11	HNRNPM	19	mRNA Splicing - Major Pathway; FGFR2 alternative splicing	Spliceosome	0
High	Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2	0	99.281	37	25	120	24	856	95.7	6.92	21	16	19	20	32	24	29	35	42863632.28	42609681.28	42251922.67	50915781.52	28	26	23	23		metabolic process;regulation of biological process;response to stimulus	nucleus	protein binding;RNA binding	"Pf00622, Pf02037, Pf13671"	11100	ENSG00000105323.16	HNRNPUL1	19	mRNA Splicing - Major Pathway	Influenza A	2
High	Q5UIP0	Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2	0	161.58	27	50	118	50	2472	274.3	5.52	1	19	41	30	1	22	56	39	1348705.768	34682652.82	76899168.03	59928436.89	8	40	45	41		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;membrane;nucleus	protein binding	Pf12231	55183	ENSG00000080345.17	RIF1	2	Nonhomologous End-Joining (NHEJ)	Signaling pathways regulating pluripotency of stem cells	0
High	P35658	Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2	0	147.994	24	34	117	34	2090	213.5	7.47		29	29	17		50	43	24	8174403.395	70749381.94	65695761.22	35042924.45	5	32	32	28		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;nucleus	protein binding;structural molecule activity;transporter activity		8021	ENSG00000126883.16	NUP214	9	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; HuR (ELAVL1) binds and stabilizes mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	Epstein-Barr virus infection; RNA transport	0
High	Q08211	ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4	0	103.724	29	31	115	31	1270	140.9	6.84	24	22	19	22	31	31	24	29	34186781.81	42282401.68	74676293.89	92892465.81	28	28	27	30		cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00035, Pf00270, Pf00271, Pf04408, Pf07717"	1660	ENSG00000135829.16	DHX9	1	TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; mRNA Splicing - Major Pathway; DEx/H-box helicases activate type I IFN and inflammatory cytokines production		0
High	Q5BKY9	Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1	0	53.134	29	10	111	10	247	28.4	10.02	9	10	10	9	28	31	27	25	145669997	136375403.4	170115269.3	184721072.2	11	11	11	11				RNA binding		257415	ENSG00000234545.7	FAM133B	7			0
High	P42167	"Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2"	0	112.893	57	18	111	9	454	50.6	9.38		16	18	16		35	47	29	455556.7422	33268191.56	34758550.19	16830155.91	3	8	8	7	Met-loss [N-Term]	regulation of biological process	chromosome;cytoplasm;membrane;nucleus	DNA binding;protein binding	"Pf03020, Pf08198"	7112	ENSG00000120802.13	TMPO	12	Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin		0
High	Q92922	SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3	0	113.984	31	28	106	21	1105	122.8	5.76	16	17	15	21	25	26	26	29	36771781.34	30242535.73	23156854.84	43698259.38	22	21	22	22	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;nucleus	DNA binding;protein binding	Pf04433	6599	ENSG00000173473.10	SMARCC1	3	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		9
High	P13647	"Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3"	0	72.099	37	24	105	14	590	62.3	7.74	20	22	18	15	26	34	24	21	25704234.27	26176692.72	16033245.78	23758826.81	18	18	16	16		cell death;cell organization and biogenesis;metabolic process	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;motor activity;protein binding;structural molecule activity	"Pf00038, Pf01576, Pf02994, Pf03961, Pf04111, Pf05957, Pf12128"	3852	ENSG00000186081.11	KRT5	12	Formation of the cornified envelope; Type I hemidesmosome assembly		4
High	O00571	ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3	0	87.81	45	25	101	24	662	73.2	7.18	19	18	16	19	26	25	24	26	30439936.23	40124700.22	38113382.13	47020760.91	22	24	22	23		cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf04851"	1654	ENSG00000215301.9	DDX3X	X	Neutrophil degranulation	Viral carcinogenesis; Hepatitis B; RIG-I-like receptor signaling pathway	1
High	P11940	Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2	0	76.729	34	24	100	16	636	70.6	9.5	18	12	17	18	32	19	23	26	37334257.7	19156495.83	29071733.28	34762302.67	24	21	22	21		metabolic process;regulation of biological process	cytoplasm;cytosol;membrane;nucleus;spliceosomal complex	protein binding;RNA binding;translation regulator activity	"Pf00076, Pf00658, Pf13893, Pf14259"	26986	ENSG00000070756.15	PABPC1	8	AUF1 (hnRNP D0) binds and destabilizes mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA	RNA degradation; mRNA surveillance pathway; RNA transport	8
High	P42166	"Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2"	0	116.425	49	22	99	13	694	75.4	7.66		17	21	16		35	39	25	5310327.516	67183107.83	69283293.94	44749611	7	21	20	17	Met-loss [N-Term]	regulation of biological process	chromosome;nucleus	DNA binding;protein binding	"Pf03020, Pf08198, Pf11560"	7112	ENSG00000120802.13	TMPO	12			11
High	P51991	Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2	0	109.742	51	22	97	21	378	39.6	9.01	11	20	11	14	20	35	18	24	61920876.73	133045243.1	68487742.59	87631721.03	20	22	18	21	Acetyl [N-Term]	metabolic process;transport	cytoplasm;nucleus;spliceosomal complex	protein binding;RNA binding;transporter activity	"Pf00076, Pf13893, Pf14259"	220988	ENSG00000170144.20	HNRNPA3	2	mRNA Splicing - Major Pathway	Spliceosome	0
High	P62701	"40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2"	0	54.045	57	17	97	17	263	29.6	10.15	13	15	17	13	22	26	27	22	26663113.28	36538823.47	42011574.09	37474278.25	17	16	17	16		cell organization and biogenesis;development;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00900, Pf08071"	6191	ENSG00000198034.10	RPS4X	X	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q8N5F7	NF-kappa-B-activating protein OS=Homo sapiens OX=9606 GN=NKAP PE=1 SV=1	0	76.985	27	10	95	6	415	47.1	10.11	8	10	9	10	26	25	21	23	58564879.19	56883425.59	50375132.91	60485339.17	11	11	10	11		cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	DNA binding;protein binding;RNA binding	Pf06047	79576	ENSG00000101882.9	NKAP	X			3
High	Q92974	Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4	0	120.384	35	29	93	29	986	111.5	7.27		21	26	20		27	38	28	965067.7754	40495885.52	51970597.03	34590239.33	8	25	25	25		cell division;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;Golgi;membrane	metal ion binding;protein binding	"Pf00130, Pf00169, Pf00621, Pf07649"	9181	ENSG00000116584.17	ARHGEF2	1	G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle	Pathogenic Escherichia coli infection	0
High	P39023	60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2	0	66.84	41	15	92	15	403	46.1	10.18	11	15	13	10	20	26	27	19	24370180.45	27580092.97	33349296.17	29477942.7	17	15	15	15		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytoplasm;cytosol;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf00297	6122	ENSG00000100316.15	RPL3	22	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P51610	Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2	0	83.875	18	27	92	27	2035	208.6	7.46		21	22	12		33	36	23	12667550.52	58454261.8	66679394.09	52154844.98	7	23	22	22	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus	catalytic activity;protein binding	"Pf01344, Pf13415, Pf13418, Pf13854, Pf13964"	3054	ENSG00000172534.13	HCFC1	X	Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones; UCH proteinases	Herpes simplex infection	0
High	P12956	X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2	0	113.114	54	28	91	28	609	69.8	6.64		24	19	16		41	29	21	2057564.18	74731027.77	40346478.94	25647063.55	12	28	27	24		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf02037, Pf02735, Pf03730, Pf03731"	2547	ENSG00000196419.12	XRCC6	22	2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ)	Non-homologous end-joining	0
High	Q15424	Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4	0	62.297	22	17	89	9	915	102.6	5.47	11	15	16	12	20	22	27	20	28454544.47	26301842.34	31029100.22	28602925.22	16	17	16	16		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf02037, Pf13893, Pf14259"	6294	ENSG00000160633.12	SAFB	19			9
High	P02533	"Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4"	0	55.265	40	16	88	6	472	51.5	5.16	12	14	12	11	24	25	20	19	19997423.11	15984353.66	9242474.18	14143381.64	12	13	10	10		cell death;cell differentiation;cell organization and biogenesis;response to stimulus	cytoplasm;cytosol;nucleus	protein binding;structural molecule activity	"Pf00038, Pf13514"	3861	ENSG00000186847.5	KRT14	17	Formation of the cornified envelope; Type I hemidesmosome assembly		6
High	Q92734	Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2	0	87.723	44	12	88	12	400	43.4	5.1	10	11	10	11	17	24	21	26	72801175.31	81167695.69	56678935.44	88030774.5	15	14	14	14		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane	protein binding;signal transducer activity	"Pf00564, Pf08232"	10342	ENSG00000114354.13	TFG	3	COPII (Coat Protein 2) Mediated Vesicle Transport	Pathways in cancer; Thyroid cancer	0
High	Q92499	ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2	0	90.006	43	26	88	26	740	82.4	7.23	14	19	15	22	18	23	19	28	20314225.14	26115161.66	20068934.48	27505666.06	22	24	25	24		cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf00622"	1653	ENSG00000079785.14	DDX1	2	tRNA processing in the nucleus		0
High	O15294	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3	0	94.01	28	26	83	26	1046	116.9	6.7		19	24	19		25	35	23	1339897.484	32881127.83	43432853.91	35347616.55	6	25	26	25		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;protein binding	"Pf00515, Pf04184, Pf07719, Pf13176, Pf13181, Pf13374, Pf13414, Pf13424, Pf13428, Pf13429, Pf13431, Pf13432, Pf13844, Pf14559"	8473	ENSG00000147162.13	OGT	X	HATs acetylate histones; UCH proteinases	Other types of O-glycan biosynthesis; Insulin resistance	0
High	Q06830	Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1	0	50.74	74	15	82	12	199	22.1	8.13	11	10	11	12	21	21	21	19	36087334.38	44557376.98	53797634.19	52128866.5	14	15	13	13		cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;mitochondrion;nucleus	antioxidant activity;catalytic activity;protein binding;RNA binding	"Pf00578, Pf08534, Pf10417"	5052	ENSG00000117450.13	PRDX1	1	TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species	Peroxisome	2
High	P51532	Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2	0	93.416	17	26	81	14	1647	184.5	7.88	16	13	13	23	23	16	14	28	34880393.13	28184906.23	23597540.25	41139832.17	27	27	24	24		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619"	6597	ENSG00000127616.17	SMARCA4	19	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; Formation of the beta-catenin:TCF transactivating complex; Interleukin-7 signaling		12
High	Q9NVI7	ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A PE=1 SV=2	0	70.048	42	23	81	9	634	71.3	8.98	13	13	17	18	18	16	21	26	19293475.67	20477221.83	37310170.15	49928266.88	20	19	21	22		cell growth;regulation of biological process	membrane;mitochondrion	catalytic activity;nucleotide binding;RNA binding	"Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401"	55210	ENSG00000197785.13	ATAD3A	1			13
High	Q9Y383	Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2	0	68.762	45	16	80	16	392	46.5	10.01	9	11	14	12	12	20	28	20	23567423.31	43230723.28	51602135.81	37345124.59	16	15	16	15	Met-loss+Acetyl [N-Term]	cell organization and biogenesis	nucleus;spliceosomal complex	protein binding;RNA binding	Pf03194	51631	ENSG00000146963.17	LUC7L2	7			0
High	P78527	DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3	0	87.98	9	35	80	35	4128	468.8	7.12	1	14	27	32	1	14	28	37	7129102.281	16064612.2	20073860.76	30798435.41	16	33	34	34		cell death;cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus	cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00454, Pf02259, Pf02260, Pf08163"	5591	ENSG00000253729.7	PRKDC	8	Nonhomologous End-Joining (NHEJ); E3 ubiquitin ligases ubiquitinate target proteins; IRF3-mediated induction of type I IFN	Non-homologous end-joining; Cell cycle	0
High	O95625	Zinc finger and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ZBTB11 PE=1 SV=2	0	117.471	37	32	79	32	1053	119.3	8.66		16	32	3		21	55	3	76117.22852	37924984.3	92780964.19	8259151.359	2	24	26	14		metabolic process;regulation of biological process	nucleus	DNA binding;metal ion binding;protein binding	"Pf00651, Pf13465"	27107	ENSG00000066422.4	ZBTB11	3			0
High	Q96DT7	Zinc finger and BTB domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZBTB10 PE=1 SV=2	0	84.339	27	17	79	17	871	94.8	5.16		13	17	15		22	32	25	687595.9336	28654119.52	39710121.31	38932162.05	5	17	18	18	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process	nucleus	DNA binding;metal ion binding;protein binding	"Pf00096, Pf00651, Pf13465"	65986	ENSG00000205189.11	ZBTB10	8			0
High	P17844	Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1	0	61.618	40	23	79	16	614	69.1	8.92	15	14	12	16	20	20	17	22	30381334.25	36980476.06	33289525.5	37457709.94	21	22	21	21		cell differentiation;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus;spliceosomal complex	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf08061"	1655	ENSG00000108654.13	DDX5	17	mRNA Splicing - Major Pathway	Spliceosome; Proteoglycans in cancer; Transcriptional misregulation in cancer	6
High	Q9Y3I0	RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1	0	83.826	47	16	78	16	505	55.2	7.23	11	12	11	14	16	21	18	23	16403693.5	24108876.81	18319665.28	27550035.75	13	14	14	14		metabolic process	cytoplasm;cytosol;membrane;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding	Pf01139	51493	ENSG00000100220.11	C22orf28; RTCB	22	tRNA processing in the nucleus		0
High	Q8NDV7	Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2	0	77.671	19	26	77	25	1962	210.2	7.01	22	18	7	17	26	20	10	21	52112586.09	59352583.44	57429898.23	69410306.3	20	22	14	19		regulation of biological process;response to stimulus	cytoplasm;cytosol;Golgi	protein binding;RNA binding	"Pf10427, Pf13893, Pf14259"	27327	ENSG00000090905.18	TNRC6A	16	Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence		1
High	Q9UKV8	Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3	0	64.504	27	20	77	15	859	97.1	9.19	18	14	12	13	27	19	14	17	27543494.53	19231621.34	12721525	23502030.75	21	17	17	19		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	"Pf02170, Pf02171, Pf08699"	27161	ENSG00000123908.11	AGO2; EIF2C2	8	Post-transcriptional silencing by small RNAs; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation		5
High	P08779	"Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4"	0	44.9	38	15	77	5	473	51.2	5.05	9	9	12	12	19	19	19	20	1720122.338	901678.459	779910.4063	3471078.484	4	3	2	5		cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;regulation of biological process;response to stimulus	cytoskeleton;cytosol;nucleus	protein binding;structural molecule activity	"Pf00038, Pf07888, Pf13514"	3868	ENSG00000186832.8	KRT16	17	Formation of the cornified envelope		0
High	P19338	Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3	0	58.93	29	18	77	18	710	76.6	4.7	15	11	14	10	21	17	23	16	29732624.97	25764403.5	51880406.28	42219010.34	17	16	17	16		regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	4691	ENSG00000115053.15	NCL	2	Major pathway of rRNA processing in the nucleolus and cytosol	Pathogenic Escherichia coli infection	0
High	Q66PJ3	ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=2	0	60.204	23	10	76	10	421	44.9	10.93	8	9	10	10	18	19	19	20	81228185.34	72685352.31	54616892.88	77761266.69	10	10	10	10		metabolic process	nucleus	protein binding;RNA binding	Pf10500	51329	ENSG00000182196.13	ARL6IP4	12			0
High	P05141	ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7	0	41.655	46	14	76	5	298	32.8	9.69	4	11	12	14	6	16	23	31	4623892.711	15925550.03	60822180.5	125250545.8	9	12	13	14	Met-loss+Acetyl [N-Term]	regulation of biological process;transport	membrane;mitochondrion;nucleus	protein binding;RNA binding;transporter activity	Pf00153	292	ENSG00000005022.5	SLC25A5	X	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Regulation of insulin secretion	cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway	9
High	P62424	60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2	0	54.921	45	17	75	17	266	30	10.61	11	14	14	15	16	19	21	19	25633194.41	32412728.31	41863646.06	36722953	15	15	16	16		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01248	6130	ENSG00000280858.2; ENSG00000148303.16	RPL7A	9; CHR_HG2030_PATCH	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q02878	60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3	0	51.796	44	15	74	15	288	32.7	10.58	9	13	12	12	16	21	18	19	22463601.64	35336300.75	39926200.78	29757785.47	15	15	16	15		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;nucleus;ribosome	DNA binding;protein binding;RNA binding;structural molecule activity	"Pf01159, Pf03868"	6128	ENSG00000089009.15	RPL6	12	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P50402	Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1	0	53.26	50	13	72	13	254	29	5.5		12	10	9		27	25	20	989657.9063	130489403.6	90603909.71	72697075.94	5	13	13	13	Acetyl [N-Term]	cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;endoplasmic reticulum;membrane;nucleus	protein binding	Pf03020	2010	ENSG00000102119.10	EMD	X	Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM)	0
High	P61247	40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2	0	57.203	58	17	72	17	264	29.9	9.73	9	12	13	12	15	17	19	21	17123635.36	26176969.25	24814890.41	21309642.84	15	16	15	15		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01015	6189	ENSG00000145425.9	RPS3A	4	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P63261	"Actin, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=ACTG1 PE=1 SV=1"	0	74.438	60	16	71	1	375	41.8	5.48	10	10	10	15	14	16	15	26	428280.9063	465276.2188	496425.6875	729895.9375	1	1	1	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	nucleotide binding;protein binding;structural molecule activity	Pf00022	71	ENSG00000184009.9	ACTG1	17	Signaling by BRAF and RAF fusions; Formation of annular gap junctions; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Clathrin-mediated endocytosis; Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; RHO GTPases activate IQGAPs; Signaling by RAS mutants; Recycling pathway of L1; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Translocation of GLUT4 to the plasma membrane; Adherens junctions interactions; EPH-ephrin mediated repulsion of cells; Paradoxical activation of RAF signaling by kinase inactive BRAF; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate Formins; Interleukin-20 family signaling	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis	0
High	P13639	Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4	0	67.358	30	23	71	22	858	95.3	6.83	11	11	19	17	13	14	23	21	11569995.22	16918830.87	24695105.91	25135650.63	19	21	21	22	Met-loss [N-Term]	cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;ribosome	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492"	1938	ENSG00000167658.15	EEF2	19	Peptide chain elongation; Protein methylation; Synthesis of diphthamide-EEF2; Neutrophil degranulation; Uptake and function of diphtheria toxin	Oxytocin signaling pathway; AMPK signaling pathway	1
High	P60709	"Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1"	0	77.362	60	16	70	1	375	41.7	5.48	11	9	11	14	15	15	16	24	35601924.64	38709772.08	41990689.72	67858504.5	15	15	15	16	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	DNA binding;nucleotide binding;protein binding;structural molecule activity	Pf00022	60	ENSG00000075624.13	ACTB	7	Formation of annular gap junctions; Cell-extracellular matrix interactions; UCH proteinases; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; Factors involved in megakaryocyte development and platelet production; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Prefoldin mediated transfer of substrate  to CCT/TriC; EPHB-mediated forward signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Folding of actin by CCT/TriC; DNA Damage Recognition in GG-NER; Regulation of actin dynamics for phagocytic cup formation; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Clathrin-mediated endocytosis; VEGFA-VEGFR2 Pathway; HATs acetylate histones; RHO GTPases activate IQGAPs; Recycling pathway of L1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Adherens junctions interactions; RHO GTPases Activate WASPs and WAVEs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Dilated cardiomyopathy; Hippo signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Thyroid hormone signaling pathway; Phagosome; Apoptosis; Focal adhesion; Proteoglycans in cancer; Salmonella infection; Adherens junction; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Gastric acid secretion; Bacterial invasion of epithelial cells; Vibrio cholerae infection; Viral myocarditis; Influenza A; Hypertrophic cardiomyopathy (HCM); Platelet activation; Shigellosis	18
High	Q14151	Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1	0	55.296	18	13	69	5	953	107.4	6.16	10	12	10	7	17	18	19	15	2461241	2977154.406	2895143.531	3379810.75	4	5	4	4		cell differentiation;metabolic process;regulation of biological process	cytoplasm;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf02037, Pf13893, Pf14259"	9667	ENSG00000130254.11	SAFB2	19			0
High	P63104	14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1	0	64.653	60	13	68	9	245	27.7	4.79	2	13	11	12	2	26	20	20	1269110.414	32165478.03	32251600	35169675	6	10	10	9	Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;protein binding;RNA binding	Pf00244	7534	ENSG00000164924.17	YWHAZ	8	"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Interleukin-3, 5 and GM-CSF signaling; KSRP (KHSRP) binds and destabilizes mRNA; Activation of BAD and translocation to mitochondria ; GP1b-IX-V activation signalling; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs"	Viral carcinogenesis; Pathogenic Escherichia coli infection; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway	0
High	P55795	Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1	0	57.162	32	11	68	5	449	49.2	6.3	8	8	9	8	14	17	19	18	2433769.031	3744182.656	3357841.594	3885134.875	3	5	5	5		metabolic process	cytosol;membrane;nucleus	protein binding;RNA binding	"Pf00076, Pf08080, Pf14259"	3188	ENSG00000126945.8	HNRNPH2	X	mRNA Splicing - Major Pathway		0
High	P09874	Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4	0	92.139	37	28	66	28	1014	113	8.88	1	25	14	9	1	38	17	10	607659.9961	45188940.81	14264696.16	9453122.352	7	25	22	18	Met-loss+Acetyl [N-Term]	cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	membrane;mitochondrion;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063"	142	ENSG00000143799.12	PARP1	1	POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); SUMOylation of DNA damage response and repair proteins	Base excision repair; NF-kappa B signaling pathway; Apoptosis	0
High	P08238	Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4	0	79.185	30	20	66	8	724	83.2	5.03	4	7	16	14	4	7	23	32	4946698.008	10877791.42	23186514.19	26230903.28	14	16	17	17		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen	enzyme regulator activity;nucleotide binding;protein binding;RNA binding	"Pf00183, Pf02518, Pf13589"	3326	ENSG00000096384.19	HSP90AB1	6	Sema3A PAK dependent Axon repulsion; HSF1 activation; Attenuation phase; Neutrophil degranulation; Aryl hydrocarbon receptor signalling; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint	NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation	10
High	Q96RN5	Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2	0	32.995	11	10	66	10	788	86.7	9.42	7	6	8	7	16	17	16	17	25094507.25	28653955.94	34115586.06	35917742.34	9	9	9	9		metabolic process;regulation of biological process	cytoplasm;membrane;nucleus	protein binding	Pf09606	51586	ENSG00000099917.17	MED15	22	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway		0
High	P63208	S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2	0	72.036	77	13	65	13	163	18.6	4.54		9	12	13		16	26	23	1062491.063	45639342.12	86174113.33	91718133.56	3	13	16	14		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	"Pf01466, Pf03931"	6500	ENSG00000113558.18	SKP1	5	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling	TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; Oocyte meiosis; Circadian rhythm; Herpes simplex infection; Cell cycle	0
High	P48668	"Keratin, type II cytoskeletal 6C OS=Homo sapiens OX=9606 GN=KRT6C PE=1 SV=3"	0	57.676	37	21	65	10	564	60	8	13	9	9	19	16	15	12	22	5245541.469	1599415.172	1709407.938	6529060.563	9	7	5	9		cell death;cell organization and biogenesis;metabolic process	cytosol	catalytic activity;motor activity;protein binding;structural molecule activity	"Pf00038, Pf01576, Pf04111, Pf13166"	286887; 3853	ENSG00000170465.9	KRT6C; KRT6A	12	Formation of the cornified envelope		0
High	Q5T9A4	ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1	0	41.72	31	18	64	4	648	72.5	9.2	10	10	14	15	13	13	18	20	2938864.938	2304296.938	3200148.375	6658146.5	2	2	3	4		transport	membrane;mitochondrion	catalytic activity;nucleotide binding;RNA binding	"Pf00004, Pf00910, Pf01078, Pf05707, Pf07726, Pf07728, Pf12037, Pf13207, Pf13401"	83858	ENSG00000160072.19	ATAD3B	1	Neutrophil degranulation		0
High	P36578	60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5	0	43.482	33	14	62	14	427	47.7	11.06	12	9	11	9	19	15	16	12	18991439.16	24382326.69	27766609.5	23690740.94	15	14	14	13		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00573, Pf14374"	6124	ENSG00000174444.14	RPL4	15	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P12236	ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4	0	38.103	48	14	61	5	298	32.8	9.74	3	7	10	14	5	10	18	28	345899.3906	724377.6641	2937366.344	6012814.375	3	2	3	3	Met-loss+Acetyl [N-Term]	cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport	membrane;mitochondrion;nucleus	protein binding;transporter activity	Pf00153	293	ENSG00000169100.13	SLC25A6	X|Y; X	Mitochondrial protein import; Regulation of insulin secretion; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Influenza Virus Induced Apoptosis; Metabolism of proteins	cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway	0
High	P27348	14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1	0	65.926	57	16	60	11	245	27.7	4.78	1	15	13	12	1	23	19	17	2135694.664	53330974.44	39139483.31	47429375.63	6	11	11	9		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion	protein binding	Pf00244	10971	ENSG00000134308.13	YWHAQ	2	Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs	Viral carcinogenesis; Pathogenic Escherichia coli infection; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway	1
High	P15924	Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3	0	69.892	12	32	57	32	2871	331.6	6.81	22	10	6	14	27	10	6	14	17611819.48	11548036.53	12494563.23	16160875.59	28	24	26	27		cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;membrane;nucleus	catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity	"Pf00038, Pf00681, Pf01540, Pf01576, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06008, Pf06160, Pf06637, Pf07888, Pf10174, Pf12072, Pf12128, Pf13166"	1832	ENSG00000096696.13	DSP	6	Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0
High	Q14457	Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2	0	67.952	42	17	57	17	450	51.9	4.89		17	11	9		31	14	12	27913400.98	137999285.3	74359307.86	65211566.47	5	18	17	14		cell communication;cell death;cell division;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus;vacuole	protein binding	"Pf04111, Pf12777, Pf13851, Pf15285"	8678	ENSG00000126581.12	BECN1	17	Ub-specific processing proteases; Macroautophagy; Interleukin-7 signaling	Apoptosis - multiple species; Autophagy	0
High	P15880	40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2	0	35.424	43	12	57	12	293	31.3	10.24	11	9	11	10	16	13	14	14	13187748.63	23585042.48	25584905.5	23621656.31	12	12	12	11		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00333, Pf03719"	6187	ENSG00000140988.15	RPS2	16	"Peptide chain elongation; Protein methylation; Eukaryotic Translation Termination; Viral mRNA Translation; RMTs methylate histone arginines; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1	0	74.217	55	16	57	7	330	37.5	6.33	1	14	15	10	1	23	22	11	948870.5469	31155666.47	27988852.64	18165503.75	5	15	14	14	Met-loss+Acetyl [N-Term]	cell division;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;metal ion binding;protein binding	Pf00149	5499	ENSG00000172531.14	PPP1CA	11	Signaling by GPCR; Triglyceride catabolism; DARPP-32 events; Downregulation of TGF-beta receptor signaling; Circadian Clock	Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation	9
High	P62906	60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2	0	35.818	35	8	57	8	217	24.8	9.94	7	8	8	7	12	15	13	17	13938567.22	16991043.47	22053897.88	21568572.19	8	8	8	8		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf00687	4736	ENSG00000198755.10	RPL10A	6	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q92841	Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2	0	40.328	21	15	57	8	729	80.2	8.27	12	8	9	11	18	13	12	14	5630439.844	6177438.703	6014538.234	7097228.109	8	7	7	8		cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271"	10521	ENSG00000100201.20	DDX17	22			0
High	Q9BUF5	Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1	0	48.346	30	13	56	4	446	49.8	4.88	5	5	7	13	5	9	17	25	214509.3438	404616.1172	2074990.188	2340046.656	1	2	4	4		cell organization and biogenesis	cytoplasm;cytoskeleton;nucleus	catalytic activity;nucleotide binding;structural molecule activity	"Pf00091, Pf03953, Pf10644"	84617	ENSG00000176014.12	TUBB6	18	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation	Pathogenic Escherichia coli infection; Gap junction; Phagosome	0
High	Q5VT25	Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1	0	80.432	18	24	55	24	1732	197.2	6.58		17	23	4		21	29	5	2544873.961	19563734.38	21281078.8	10079443.31	4	19	19	14		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;extracellular;Golgi	catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity	"Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00769, Pf00780, Pf01442, Pf01576, Pf02463, Pf03999, Pf04012, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06160, Pf06785, Pf07714, Pf07888, Pf08317, Pf08826, Pf09726, Pf09730, Pf09755, Pf10174, Pf10498, Pf12037, Pf12128, Pf12718, Pf12795, Pf13514, Pf13851, Pf13868, Pf14362, Pf14531, Pf14915, Pf15558, Pf15619"	8476	ENSG00000143776.18	CDC42BPA	1			0
High	P61353	60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2	0	27.757	51	8	54	8	136	15.8	10.56	6	5	7	5	14	13	16	11	17376862.94	22237265.75	28612917.78	27231495.31	8	8	8	8		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;nucleus;ribosome	RNA binding;structural molecule activity	"Pf00467, Pf01777"	6155	ENSG00000131469.12	RPL27	17	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P05387	60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1	0	51.404	77	6	53	6	115	11.7	4.54	6	6	6	6	11	12	15	15	23947227.53	30755637.69	47411997.13	39745290.56	7	7	7	7		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;structural molecule activity	Pf00428	6181	ENSG00000177600.8	RPLP2	11	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q8TA86	Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2	0	34.946	43	9	53	9	221	26.1	9.79	7	6	8	6	15	9	17	12	23885683.13	26820012.91	25694468.41	28428733.45	10	10	10	10	Met-loss+Acetyl [N-Term]	metabolic process	cytosol;nucleus	metal ion binding;protein binding;RNA binding		6100	ENSG00000164610.8	RP9	7		Spliceosome	0
High	Q9UBS9	SUN domain-containing ossification factor OS=Homo sapiens OX=9606 GN=SUCO PE=1 SV=1	0	78.348	21	21	53	21	1254	139.3	5.01	1	21	8	4	1	38	10	4	902996.7578	59249878.31	8273209.578	2542664.445	6	20	14	9		development;regulation of biological process	endoplasmic reticulum;membrane		"Pf07738, Pf12004"	51430	ENSG00000094975.13	SUCO	1			0
High	P13010	X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3	0	72.102	34	22	53	22	732	82.7	5.81		19	9	9		26	16	11	1066132.195	39676602.88	22315238.09	15830748.55	5	19	17	16		cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding	"Pf02735, Pf03730, Pf03731, Pf08785"	7520	ENSG00000079246.15	XRCC5	2	2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ)	Non-homologous end-joining	0
High	P31946	14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3	0	37.923	52	13	53	6	246	28.1	4.83	1	13	9	10	1	20	15	17		13166356.63	10088440.38	12910993.94		6	6	6		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus	protein binding	Pf00244	7529	ENSG00000166913.12	YWHAB	20	"MAP2K and MAPK activation; mTORC1-mediated signalling; Negative regulation of MAPK pathway; ARMS-mediated activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Interleukin-20 family signaling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by BRAF and RAF fusions; Signaling by Hippo; Activation of BAD and translocation to mitochondria ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; TP53 Regulates Metabolic Genes; RAF activation; RHO GTPases activate PKNs"	Viral carcinogenesis; Hepatitis B; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway	0
High	P25705	"ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1"	0	52.404	35	18	52	18	553	59.7	9.13	2	3	14	18	2	3	20	27	2820673.043	5627284.609	29770161.47	69594716.41	9	11	17	18		cell organization and biogenesis;metabolic process;regulation of biological process;transport	membrane;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity	"Pf00006, Pf00306, Pf02663, Pf02874, Pf05943"	498	ENSG00000152234.15	ATP5A1	18	Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways	0
High	Q15464	SH2 domain-containing adapter protein B OS=Homo sapiens OX=9606 GN=SHB PE=1 SV=2	0	60.718	45	17	52	17	509	55	8.9		16	4	15		25	5	22	297537.125	59908043.25	10851795.52	53298209.84	1	17	15	17		cell death;cell differentiation;cell proliferation;development;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	protein binding	Pf00017	6461	ENSG00000107338.9	SHB	9	VEGFA-VEGFR2 Pathway		0
High	Q86X95	Corepressor interacting with RBPJ 1 OS=Homo sapiens OX=9606 GN=CIR1 PE=1 SV=1	0	34.15	29	15	51	15	450	52.3	9.86	13	10	8	9	16	13	11	11	21327175.25	18543046.13	17052420.13	22778094.13	13	13	12	13		metabolic process;regulation of biological process	cytoplasm;cytoskeleton;nucleus	protein binding	Pf10197	9541	ENSG00000138433.15	CIR1	2		Notch signaling pathway	0
High	P02768	Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2	0	26.277	10	7	51	7	609	69.3	6.28	4	5	6	6	9	13	15	14	10333681.55	26281733.63	26833673.86	34256344.38	5	6	6	7		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus;organelle lumen	antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding	Pf00273	213	ENSG00000163631.16	ALB	4	"Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma; Platelet degranulation ; Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR); HDL remodeling; Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR); Transport of organic anions; Recycling of bile acids and salts"	Thyroid hormone synthesis	0
High	P67809	Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3	0	50.433	70	11	51	7	324	35.9	9.88	6	8	8	10	8	13	15	15	14640236.17	21462880.94	26609239.69	27837718.06	9	12	12	12	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process	cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	Pf00313	4904	ENSG00000065978.18	YBX1	1	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway		5
High	P62241	40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2	0	31.73	51	10	50	10	208	24.2	10.32	10	9	9	7	11	14	13	12	16495528.09	23599936.19	23283549.06	20276314.28	10	10	10	10		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01201	6202	ENSG00000142937.11	RPS8	1	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q99567	Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2	0	60.864	37	20	50	20	741	83.5	5.69		16	13	10		23	16	11	773110.375	29144508.97	25269851.36	14178717.78	2	18	18	13		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytosol;nucleus	protein binding;transporter activity	"Pf02050, Pf07767, Pf09789, Pf10168"	4927	ENSG00000108559.11	NUP88	17	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	P23246	"Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2"	0	50.977	31	16	50	15	707	76.1	9.44	11	9	6	15	12	11	8	19	20492460.15	18910831.28	15390844.28	33986104.5	14	13	12	12		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf08075, Pf13893, Pf14259"	6421	ENSG00000116560.10	SFPQ	1	PTK6 Regulates Proteins Involved in RNA Processing		1
Medium	Q5M775	Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1	0.021	1.519	1	1	49	1	1068	118.5	6.7	1	1	1	1	8	12	18	11	3008099880	3098423051	3441161172	4110919850	1	1	1	1		cell organization and biogenesis;metabolic process;transport	cytoskeleton;Golgi;membrane;nucleus	catalytic activity;motor activity;protein binding;transporter activity	"Pf00307, Pf01496, Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05478, Pf05667, Pf06160, Pf07888, Pf09730, Pf10174, Pf11971, Pf12128"	92521	ENSG00000128487.16	SPECC1	17			0
High	Q9NR30	Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5	0	53.657	29	19	49	19	783	87.3	9.28	10	6	14	9	12	7	19	11	9245925.281	7779213.5	15062004.61	15266309.45	17	16	18	18		cell differentiation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf08152, Pf14617"	9188	ENSG00000165732.12	DDX21	10	Major pathway of rRNA processing in the nucleolus and cytosol; B-WICH complex positively regulates rRNA expression		0
High	P07910	Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4	0	33.111	34	12	49	12	306	33.7	5.08	8	11	9	8	12	13	14	10	17846680.31	18093747.13	15157971.42	16090434.88	11	11	12	11		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process	cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	3183	ENSG00000092199.17	HNRNPC	14	mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins	Spliceosome	0
High	P05388	60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1	0	39.293	34	10	48	10	317	34.3	5.97	8	7	10	8	12	9	16	11	15147521.56	17619401.41	25014152.47	21224950.19	10	10	10	10		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00428, Pf00466"	6175	ENSG00000089157.15	RPLP0	12	Peptide chain elongation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Interleukin-12 family signaling	Ribosome	0
High	P50454	Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2	0	98.965	50	17	48	17	418	46.4	8.69			17	8			39	9	177794.8281	562756.6953	88791281.52	10287411.61	3	4	19	13		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;endoplasmic reticulum;membrane;organelle lumen	enzyme regulator activity;protein binding;RNA binding	Pf00079	871	ENSG00000149257.13	SERPINH1	11	Collagen biosynthesis and modifying enzymes		0
High	O43390	Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1	0	46.092	28	17	48	10	633	70.9	8.13	10	11	8	7	12	16	12	8	14189100.72	17519820.73	12151443.13	15907127.72	16	15	14	13		metabolic process;regulation of biological process	cytoplasm;endoplasmic reticulum;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10236	ENSG00000282958.1; ENSG00000125944.18	HNRNPR	1; CHR_HSCHR1_4_CTG3	mRNA Splicing - Major Pathway		7
High	P08670	Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4	0	45.212	38	16	48	16	466	53.6	5.12	13	7	12	11	18	7	12	11	13720431.17	8716100.766	11807756.06	14627225.2	14	14	15	14		cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;RNA binding;structural molecule activity	"Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186"	7431	ENSG00000026025.15	VIM	10	Interleukin-4 and 13 signaling; Caspase-mediated cleavage of cytoskeletal proteins; Striated Muscle Contraction	MicroRNAs in cancer; Epstein-Barr virus infection	0
High	Q9H9G7	Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2	0	48.794	27	16	48	12	860	97.3	9.11	13	11	6	9	17	13	8	10	6540211.531	5945716.266	2058034.438	5756341.219	11	9	8	9	Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;membrane	protein binding;RNA binding	"Pf02170, Pf02171, Pf08699"	192669	ENSG00000126070.19	AGO3; EIF2C3	1	Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence		0
High	Q9HCD5	Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2	0	46.721	31	14	47	14	579	65.5	9.6	11	8	8	9	16	10	10	11	11959412.47	10450953.34	12176981.38	10646049.61	13	12	11	12		metabolic process;regulation of biological process	cytoskeleton;nucleus	protein binding;RNA binding		57727	ENSG00000124160.11	NCOA5	20			0
High	P61981	14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2	0	34.419	45	13	47	7	247	28.3	4.89	1	11	8	11	1	16	13	17	157760.6719	25890672.81	16468012.81	18776399.53	1	8	7	6		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion	enzyme regulator activity;protein binding;RNA binding	Pf00244	7532	ENSG00000170027.6	YWHAG	7	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs	Viral carcinogenesis; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway	2
High	Q6ZNE5	Beclin 1-associated autophagy-related key regulator OS=Homo sapiens OX=9606 GN=ATG14 PE=1 SV=1	0	57.064	31	13	47	13	492	55.3	7.01		12	11	7		24	14	9	188715.6406	51646619.94	18734743.15	16573696.17	1	13	13	12		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole	protein binding	"Pf06785, Pf10186"	22863	ENSG00000126775.8	ATG14	14	Macroautophagy; Interleukin-7 signaling	Autophagy	0
High	P07237	Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3	0	68.718	42	20	46	20	508	57.1	4.87	1	20	6	8	1	31	6	8	1939752.422	45948833.94	13391369.44	10413103.94	9	18	16	13		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding;RNA binding	"Pf00085, Pf01216, Pf13098, Pf13848, Pf13899, Pf13905"	5034	ENSG00000185624.14	P4HB	17	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); VLDL assembly; Chylomicron assembly; Collagen biosynthesis and modifying enzymes; Interleukin-12 family signaling; Detoxification of Reactive Oxygen Species; Hedgehog ligand biogenesis	Protein processing in endoplasmic reticulum	0
High	P78406	mRNA export factor OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1	0	33.376	41	13	46	13	368	40.9	7.83		7	11	12		10	19	17	368676807.3	436575785.6	485801845.2	568007729.1	8	12	12	13		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;nucleus	protein binding;RNA binding	Pf00400	8480	ENSG00000101146.12	RAE1	20	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport; Influenza A	0
High	Q9UKB1	F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1	0	53.657	34	17	46	9	542	62.1	7.12		10	16	10		12	21	13	303620.1406	19200616.3	33472318.41	23345138.94	4	16	16	15		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	"Pf00400, Pf00646, Pf08801, Pf12125, Pf12937"	23291	ENSG00000072803.17	FBXW11	5	Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Neddylation; Activated TLR4 signalling; Interleukin-1 family signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling	Ubiquitin mediated proteolysis; Hippo signaling pathway; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Shigellosis	8
High	O60762	Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=DPM1 PE=1 SV=1	0	55.747	56	13	46	13	260	29.6	9.57			13	11			24	22	543822.3125	1058485.641	59196637.92	62796966.14	4	3	14	14	Met-loss+Acetyl [N-Term]	metabolic process	endoplasmic reticulum;membrane;nucleus	catalytic activity;protein binding	"Pf00535, Pf10111, Pf13641, Pf13704, Pf13712"	8813	ENSG00000000419.12	DPM1	20	Defective DPM1 causes DPM1-CDG (CDG-1e); Synthesis of dolichyl-phosphate mannose	N-Glycan biosynthesis; Metabolic pathways	0
High	P61978	Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1	0	43.509	36	15	45	15	463	50.9	5.54	6	4	14	9	9	5	19	12	8663066.906	7293201.547	12206352.66	9248485.609	11	12	11	11		metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00013, Pf08067, Pf13014, Pf13083"	3190	ENSG00000165119.20	HNRNPK	9	mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins	Viral carcinogenesis; MicroRNAs in cancer; Spliceosome; Herpes simplex infection	0
High	Q15233	Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4	0	42.727	29	12	45	11	471	54.2	8.95	6	10	7	11	6	12	8	19	13582973.06	17745006.16	15544000.78	26911786.38	11	12	12	12		defense response;metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf08075, Pf13893, Pf14259"	4841	ENSG00000147140.15	NONO	X			0
High	P62249	40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2	0	25.979	63	12	45	12	146	16.4	10.21	7	8	7	9	9	11	11	14	6300071.086	13009942.16	14505038.88	13822654.28	11	12	12	12	Met-loss [N-Term]	cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00380	6217	ENSG00000105193.8	RPS16	19	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P14866	Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2	0	38.204	25	11	45	11	589	64.1	8.22	10	7	8	9	15	8	10	12	16391884.94	9822570.25	10531462.5	10435354.75	12	11	12	12		metabolic process;regulation of biological process	cytoplasm;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	3191	ENSG00000282947.1; ENSG00000104824.16	HNRNPL	19; CHR_HG26_PATCH	mRNA Splicing - Major Pathway		0
High	Q04917	14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4	0	30.731	42	10	44	6	246	28.2	4.84	1	10	8	9	1	16	13	14	385464.3438	13330789	12409364.88	14872170.75	1	6	6	6		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion	catalytic activity;protein binding	Pf00244	7533	ENSG00000128245.14	YWHAH	22	Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs	Viral carcinogenesis; Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway	0
High	Q07020	60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2	0	23.372	36	7	43	7	188	21.6	11.72	4	7	7	5	8	13	14	8	11711815.47	16556573.75	20591176.75	18417357.19	6	6	6	6		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome	RNA binding;structural molecule activity	Pf00828	6141	ENSG00000063177.12	RPL18	19	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q7Z794	"Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3"	0	11.964	5	3	43	1	578	61.9	5.99	2	3	3	3	12	12	9	10	33508420	37890212	29395220	34323720	1	1	1	1		cell death;cell organization and biogenesis	cytoskeleton;cytosol	structural molecule activity	"Pf00038, Pf03962, Pf13166, Pf14817"	374454	ENSG00000189182.9	KRT77	12	Formation of the cornified envelope		0
High	P10321	"HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3"	0	86.879	53	18	43	11	366	40.6	6.04	1		2	18	1		2	40	713077.9375	1376237.457	4970982.406	142628360.2	3	5	9	16		regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;Golgi;membrane	protein binding	"Pf00129, Pf07654"	3107	ENSG00000204525.16	HLA-C	6	"Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC"	Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation	7
High	Q93034	Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4	0	44.728	23	17	43	17	780	90.9	7.94	10	12	6	10	11	13	6	13	18200831.86	25313340.88	28627573	42339110.75	15	15	14	16		cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;nucleus	catalytic activity;protein binding;receptor activity;transporter activity	"Pf00888, Pf10557"	8065	ENSG00000166266.13	CUL5	11	Downregulation of ERBB2 signaling; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation	Ubiquitin mediated proteolysis	0
High	P01857	Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1	0	4.428	5	2	42	2	330	36.1	8.19	2	2	2	2	10	9	10	13	85446936.94	113239498.5	193125541.8	233917282.8	3	3	3	3		cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;metal ion binding;protein binding	"Pf07654, Pf08205"	3500	ENSG00000277633.5; ENSG00000211896.7	IGHG1	14; CHR_HSCHR14_3_CTG1	Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis		0
High	P49411	"Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2"	0	48.134	36	13	42	13	452	49.5	7.61	3	8	11	12	3	9	14	16	8207587.453	16350322.11	19033923.78	34108579.81	9	11	11	12		metabolic process;response to stimulus	membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf03143, Pf03144"	7284		TUFM	16	Mitochondrial translation elongation		0
High	P68133	"Actin, alpha skeletal muscle OS=Homo sapiens OX=9606 GN=ACTA1 PE=1 SV=1"	0	38.482	34	10	42	2	377	42	5.39	6	6	7	10	9	10	8	15			1459239	1861936.375			1	1		cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol	nucleotide binding;protein binding;structural molecule activity	Pf00022	58	ENSG00000143632.14	ACTA1	1	Striated Muscle Contraction		0
High	P62280	40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3	0	32.961	53	10	42	10	158	18.4	10.3	7	7	7	7	10	9	12	11	15481749.98	29022635.38	30005941.44	23710806.91	10	10	10	10		cell differentiation;cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00366	6205	ENSG00000142534.6	RPS11	19	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q92945	Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4	0	40.104	25	13	42	13	711	73.1	7.3	11	7	8	9	11	9	9	13	14775473.84	9901802.344	9709176.531	15836747.41	11	9	9	10		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00013, Pf07650, Pf09005, Pf13014"	8570	ENSG00000088247.17	KHSRP	19	ATF4 activates genes; KSRP (KHSRP) binds and destabilizes mRNA		0
High	Q8TAQ2	SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1	0	45.539	13	14	41	7	1214	132.8	5.69	10	5	5	12	13	7	9	12	4842221.578	4371797.656	4919432.281	6665638.156	6	6	6	7		cell organization and biogenesis;metabolic process;regulation of biological process	nucleus	DNA binding;protein binding	Pf04433	6601	ENSG00000139613.11	SMARCC2	12	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		0
High	O60506	Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2	0	31.078	19	11	41	4	623	69.6	8.59	7	9	8	7	9	12	12	8	1473662.469	1269552.734	2237276.953	1231558.5	2	2	3	1		cell differentiation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;endoplasmic reticulum;membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10492	ENSG00000135316.17	SYNCRIP	6			0
High	P46781	40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3	0	22.49	40	10	41	10	194	22.6	10.65	5	9	9	9	7	11	12	11	13364030.81	21568267.36	24188084.83	19120810.52	10	10	10	10		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity;translation regulator activity	"Pf00163, Pf01479"	6203	ENSG00000274005.3; ENSG00000275323.3; ENSG00000277079.3; ENSG00000278081.3; ENSG00000277359.3; ENSG00000170889.13; ENSG00000274950.4; ENSG00000274626.3; ENSG00000278270.4; ENSG00000274646.4	RPS9	19; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q9Y385	Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2	0	76.547	52	14	41	14	318	35.2	6.74			8	14			11	30	501808.9063		30321896.91	108429599.1	1		12	13		metabolic process;regulation of biological process	cytoplasm;endoplasmic reticulum;membrane	catalytic activity;nucleotide binding;protein binding	Pf00179	51465	ENSG00000198833.6	UBE2J1	6	Antigen processing: Ubiquitination & Proteasome degradation	Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson's disease	0
High	P10809	"60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2"	0	45.955	25	12	41	12	573	61	5.87	4	4	12	9	4	5	18	14	4636716.859	5200975.898	20059321.88	17497091.59	11	10	13	12		cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endosome;membrane;mitochondrion;organelle lumen	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	Pf00118	3329	ENSG00000144381.16	HSPD1	2	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Mitochondrial protein import; Metabolism of proteins	Type I diabetes mellitus; Tuberculosis; RNA degradation; Legionellosis	0
High	O75390	"Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2"	0	24.408	18	8	40	8	466	51.7	8.32		7	8	7		13	14	13	208088.875	11890112.31	17394626.5	15777990.38	2	8	8	7		metabolic process	mitochondrion;nucleus;organelle lumen	catalytic activity;RNA binding	Pf00285	1431	ENSG00000062485.18	CS	12	Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle)	Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism	0
High	P51531	Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2	0	40.507	8	13	40	1	1590	181.2	7.2	6	8	4	12	10	11	5	14	611912.1875	712072.75	333570.4375	319580.875	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process	cytoskeleton;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619"	6595	ENSG00000080503.22	SMARCA2	9	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		0
High	Q9UBU6	Protein FAM8A1 OS=Homo sapiens OX=9606 GN=FAM8A1 PE=1 SV=1	0	68.468	36	10	40	10	413	44.1	7.21			10	4			34	6	172790.6719	357456.2031	74066657	10725841.89	1	2	11	10			membrane		Pf06271	51439	ENSG00000137414.5	FAM8A1	6			0
High	Q9Y297	F-box/WD repeat-containing protein 1A OS=Homo sapiens OX=9606 GN=BTRC PE=1 SV=1	0	45.139	23	13	40	5	605	68.8	7.96		8	12	9		10	17	13		2397955.75	4265955	3194780.563		4	4	4		cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	"Pf00400, Pf00646, Pf08801, Pf12125, Pf12937"	8945	ENSG00000166167.17	BTRC	10	Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Deactivation of the beta-catenin transactivating complex; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling	Ubiquitin mediated proteolysis; Hippo signaling pathway; Wnt signaling pathway; Oocyte meiosis; Hedgehog signaling pathway; Circadian rhythm; Shigellosis	0
High	Q9Y224	"RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1"	0	51.548	61	13	40	13	244	28.1	6.65	8	8	9	8	9	9	10	12	15132486.81	19528815	13384504.28	15506847.81	13	11	11	10		metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;nucleus	protein binding;RNA binding	Pf10036	51637	ENSG00000087302.8	C14orf166; RTRAF	14	tRNA processing in the nucleus		0
High	Q15366	Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1	0	28.138	37	8	39	5	365	38.6	6.79	8	6	6	8	10	8	10	11	12031152.94	10495638.94	12073629.13	15680334.63	7	7	8	7		defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00013, Pf13014"	5094	ENSG00000197111.15	PCBP2	12	Negative regulators of DDX58/IFIH1 signaling; mRNA Splicing - Major Pathway		3
High	P23396	40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2	0	24.751	36	9	38	9	243	26.7	9.66	5	7	9	5	7	12	12	7	8975883.344	18116896.13	19019619.88	17864989.75	9	9	9	9		cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome	catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity	"Pf00189, Pf07650"	6188	ENSG00000149273.14	RPS3	11	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q9UNF1	Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2	0	36.658	28	13	38	13	606	64.9	9.32		11	9	9		17	11	10	2650089.789	20347026.66	16072221.66	14985311.31	2	12	13	12		transport	cytosol;extracellular;membrane;nucleus;organelle lumen	protein binding	Pf01454	10916	ENSG00000102316.16	MAGED2	X	Platelet degranulation		0
High	Q92804	TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1	0	36.287	22	8	38	6	592	61.8	8.02	6	7	5	7	9	12	8	9	10206960.59	18405752.84	17395988.89	18079570.13	5	5	5	5		regulation of biological process	cytoplasm;nucleus	DNA binding;metal ion binding;protein binding;RNA binding	"Pf00076, Pf00641, Pf13893, Pf14259"	8148	ENSG00000270647.5; ENSG00000276833.2	TAF15	17; CHR_HSCHR17_7_CTG4		Basal transcription factors; Transcriptional misregulation in cancer	0
High	P23526	Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4	0	30.769	35	13	38	13	432	47.7	6.34	8	6	8	8	12	7	10	9	12367882.19	5468127.797	4850679.766	7118043.5	13	10	9	11	Met-loss+Acetyl [N-Term]	defense response;metabolic process;response to stimulus;transport	cytoplasm;cytosol;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00670, Pf02254, Pf02826, Pf05221"	191	ENSG00000101444.12	AHCY	20	"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD); Sulfur amino acid metabolism; Methylation"	Metabolic pathways; Cysteine and methionine metabolism	0
High	P62140	Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3	0	52.53	35	10	37	1	327	37.2	6.19	1	8	10	6	1	14	15	7	89076.29688	425812	514135.0938	635614.875	1	2	1	2		cell division;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	Pf00149	5500	ENSG00000213639.9	PPP1CB	2	Triglyceride catabolism; RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; Regulation of PLK1 Activity at G2/M Transition; Downregulation of TGF-beta receptor signaling; RHO GTPases activate CIT; RHO GTPases activate PKNs; Circadian Clock	Dopaminergic synapse; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Hippo signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Adrenergic signaling in cardiomyocytes; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; mRNA surveillance pathway; Oocyte meiosis; Herpes simplex infection; Inflammatory mediator regulation of TRP channels; Alcoholism; cAMP signaling pathway; Insulin resistance; Platelet activation	0
High	Q9BT22	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG1 PE=1 SV=2	0	37.774	30	10	37	10	464	52.5	7.23		8	8	7		14	12	11		25892111.56	22063147.56	23430571.45		7	7	8		metabolic process	endoplasmic reticulum;membrane	catalytic activity	"Pf00534, Pf13692"	56052	ENSG00000033011.11	ALG1	16	"Defective ALG1 causes ALG1-CDG (CDG-1k); Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"	N-Glycan biosynthesis; Metabolic pathways	0
High	Q9BZ72	Membrane-associated phosphatidylinositol transfer protein 2 OS=Homo sapiens OX=9606 GN=PITPNM2 PE=1 SV=1	0	42.016	14	16	37	15	1349	148.8	7.17		8	14	12		9	15	13		7201662.156	9574895.188	11361164.44		13	15	15		metabolic process;transport	cytosol;membrane	metal ion binding;transporter activity	"Pf02121, Pf02862, Pf08235"	57605	ENSG00000090975.12	PITPNM2	12	Synthesis of PI		1
High	Q15370	Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1	0	28.978	93	8	37	8	118	13.1	4.88	5	5	5	8	9	8	9	11	14549407.25	11948471.55	9725232.719	15131145.28	7	7	6	8	Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	protein binding	Pf00240	6923	ENSG00000103363.14	TCEB2; ELOB	16	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation	HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma	0
High	P62917	60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2	0	34.456	48	11	36	11	257	28	11.03	7	6	9	6	9	7	13	7	13283428.5	17292761	16226566.56	17453490.97	8	8	8	8		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytoplasm;cytosol;membrane;ribosome	RNA binding;structural molecule activity	"Pf00181, Pf03947"	6132	ENSG00000161016.17	RPL8	8	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P52597	Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3	0	45.422	34	10	36	9	415	45.6	5.58	6	4	6	9	8	7	9	12	9558515.078	9912593.219	10079728.97	11729063.88	8	8	7	7		metabolic process;regulation of biological process;response to stimulus	cytosol;membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf08080, Pf14259"	3185	ENSG00000169813.16	HNRNPF	10	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Interleukin-12 family signaling		0
High	P08708	40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2	0	43.935	59	7	36	7	135	15.5	9.85	5	5	6	6	10	7	8	11	15882290	15230055.63	18803865.94	18874414.63	4	4	5	5		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	RNA binding;structural molecule activity	Pf00833	6218	ENSG00000278229.2; ENSG00000182774.10	RPS17; RPS17L	15; CHR_HSCHR15_5_CTG8	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P30050	60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1	0	29.396	50	6	36	6	165	17.8	9.42	6	5	5	5	8	9	9	10	14959728.75	19324339.13	22706839.13	20697455.38	6	6	6	6		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00298, Pf03946"	6136	ENSG00000197958.12	RPL12	9	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P36542	"ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1"	0	20.282	20	6	36	6	298	33	9.22	4	5	6	6	5	9	12	10	3420352.281	6098839.875	12828494.25	17036439.94	6	6	7	7		cell organization and biogenesis;metabolic process;transport	membrane;mitochondrion;organelle lumen	catalytic activity;RNA binding;transporter activity	Pf00231	509	ENSG00000165629.19	ATP5C1	10	Cristae formation; Formation of ATP by chemiosmotic coupling	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways	0
High	P63173	60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2	0	17.704	53	5	35	5	70	8.2	10.1	3	3	4	5	6	8	8	13	6515909.078	8970330.813	8149302.625	17515360.56	4	5	5	5		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;ribosome	RNA binding;structural molecule activity	Pf01781	6169	ENSG00000172809.12	RPL38	17	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P62269	40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3	0	22.232	36	7	35	7	152	17.7	10.99	7	4	5	7	10	8	7	10	7628346.906	13658245.75	17592681.25	15054142.69	8	8	8	8		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf00416	6222	ENSG00000223367.6; ENSG00000096150.9; ENSG00000235650.6; ENSG00000226225.6; ENSG00000231500.6	RPS18	6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P62829	60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1	0	30.851	46	6	35	6	140	14.9	10.51	4	4	4	6	5	7	9	14	10704559.53	11452309.29	13452250.36	54568405.69	6	6	6	6		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00238	9349	ENSG00000125691.12	RPL23	17	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P02545	Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1	0	61.352	37	19	35	19	664	74.1	7.02		18	4	6		25	4	6	1035003.645	23675614.55	7634332.844	8258765.703	2	18	17	16		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytosol;membrane;nucleus	protein binding;structural molecule activity	"Pf00038, Pf00932"	4000	ENSG00000160789.19	LMNA	1	Signaling by BRAF and RAF fusions; Breakdown of the nuclear lamina; XBP1(S) activates chaperone genes; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Depolymerisation of the Nuclear Lamina; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Apoptosis; Hypertrophic cardiomyopathy (HCM)	0
High	Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2	0	35.344	28	14	34	12	577	63.4	9.2	10	7	8	8	11	7	8	8	137485937.7	127701175.4	124938930.7	105404519.2	13	13	14	12		cell proliferation;regulation of biological process;transport	cytoplasm;cytosol;nucleus	protein binding;RNA binding;translation regulator activity	"Pf00013, Pf00076, Pf13014, Pf13893, Pf14259"	10642	ENSG00000159217.9	IGF2BP1	17	MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	MicroRNAs in cancer	2
High	Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3	0	30.267	24	12	34	9	531	58.9	9.64	8	5	6	11	9	6	6	13	6415703.359	4553678.375	5048784.701	9338929.938	11	9	11	11		cell organization and biogenesis;metabolic process;regulation of biological process	nucleus	DNA binding;protein binding	Pf02201	6603	ENSG00000108604.15	SMARCD2	17	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		3
High	Q86TM6	E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2	0	34.621	14	11	34	11	617	67.6	6.95			11	6			23	11		904368.6484	85010284.25	17889207.97		2	12	10		metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane	catalytic activity;metal ion binding;protein binding	"Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634"	84447	ENSG00000162298.18	SYVN1	11	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes; Hedgehog ligand biogenesis	Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum	0
High	P83731	60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1	0	25.041	41	8	34	8	157	17.8	11.25	5	6	8	6	8	8	11	7	21067417.13	29070306.31	29320046.25	35198564.69	6	7	7	7		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01246	6152	ENSG00000114391.12	RPL24	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q14191	Werner syndrome ATP-dependent helicase OS=Homo sapiens OX=9606 GN=WRN PE=1 SV=2	0	51.947	17	21	34	21	1432	162.4	6.34		18	10			24	10		1201699.525	26404207.97	13975027.63	9369411.531	4	19	15	14		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf00270, Pf00271, Pf00570, Pf01612, Pf09382, Pf14493"	7486	ENSG00000165392.9	WRN	8	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates		0
High	Q00610	Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5	0	33.049	10	14	33	14	1675	191.5	5.69	6	8	5	11	8	8	5	12	6009670.078	6395510.688	5239910.68	7099971.266	12	13	13	13		cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole	protein binding;RNA binding;structural molecule activity	"Pf00637, Pf01394, Pf04053, Pf09268, Pf13838"	1213	ENSG00000141367.11	CLTC	17	"Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4"	Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle	0
High	Q99497	Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2	0	24.717	59	8	33	8	189	19.9	6.79	6	6	3	6	10	9	4	10	6594428.734	6154191.375	3377192.5	7068116.625	5	5	5	5		cell communication;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen	antioxidant activity;catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding	"Pf01965, Pf13278"	11315	ENSG00000116288.12	PARK7	1		Parkinson's disease	0
High	P27635	60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4	0	36.599	39	7	33	7	214	24.6	10.08	4	6	7	5	5	11	10	7	8751503.922	16549183.84	15548020.59	15371962.63	8	9	7	8		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;endoplasmic reticulum;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity;translation regulator activity	Pf00252	6134		RPL10	X	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	A6NKD9	Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1	0	46.957	37	14	33	14	419	45.2	6.96		7	8	12		8	11	14	36941.97656	14620008.22	16534263.72	19067701.53	1	10	13	13		development			Pf10226	317762	ENSG00000205476.8	CCDC85C	14			0
High	P31942	Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2	0	29.202	34	8	33	7	346	36.9	6.87	4	8	5	7	4	13	6	10	11303526.5	23745726.19	10557956.75	13675127	6	7	5	7		cell differentiation;metabolic process	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf14259"	3189	ENSG00000096746.17	HNRNPH3	10			0
High	Q14204	Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5	0	42.122	5	20	33	20	4646	532.1	6.4	11	1	8	11	12	1	8	12	5545982.453	2702427.883	4829217.578	8043344.25	18	14	14	18		cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen	catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding	"Pf00769, Pf03028, Pf03915, Pf04156, Pf07246, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13173, Pf13207, Pf13401"	1778	ENSG00000197102.10	DYNC1H1	14	COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR)	Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption	0
High	P01024	Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2	0	21.045	4	7	32	7	1663	187	6.4		6	6	7		11	11	10		25743988.25	33064226.63	24770387.75		7	7	7		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;enzyme regulator activity;protein binding	"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974"	718	ENSG00000125730.16	C3	19	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Alternative complement activation; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; G alpha (i) signalling events	Viral carcinogenesis; Chagas disease (American trypanosomiasis); Leishmaniasis; Tuberculosis; Pertussis; Phagosome; Complement and coagulation cascades; Systemic lupus erythematosus; Herpes simplex infection; Staphylococcus aureus infection; Legionellosis	0
High	P62851	40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1	0	12.808	30	5	32	5	125	13.7	10.11	2	4	4	5	5	8	10	9	9644950.25	15913871.13	14580034.13	15170321.5	4	4	4	4		cell organization and biogenesis;metabolic process;transport	cytosol;nucleus;ribosome	catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity	Pf03297	6230	ENSG00000280831.2; ENSG00000118181.10	RPS25	11; CHR_HG2217_PATCH	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q6IQ23	Pleckstrin homology domain-containing family A member 7 OS=Homo sapiens OX=9606 GN=PLEKHA7 PE=1 SV=2	0	37.156	12	12	32	12	1121	127.1	9.35		10	7	8		13	9	10		18946232.41	7350135.938	12249730.44		12	12	12		cell organization and biogenesis;metabolic process	cytoplasm;cytoskeleton;cytosol;nucleus	catalytic activity;motor activity;protein binding	"Pf00169, Pf00397, Pf01576, Pf01920, Pf02463, Pf03961, Pf07798, Pf14992, Pf15409, Pf15413"	144100	ENSG00000166689.15	PLEKHA7	11			0
High	P53999	Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3	0	19.812	50	7	32	7	127	14.4	9.6	5	5	5	6	6	7	8	11	15285200.34	14279800	22521048.78	23857424.81	7	7	7	7		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;protein binding;RNA binding	Pf02229	10923	ENSG00000113387.11	SUB1	5			0
High	P62888	60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2	0	30.175	59	5	32	5	115	12.8	9.63	3	5	5	3	7	11	8	6	7557167.875	11371639.82	10618634.69	9917051.625	6	7	7	6		cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01248	6156	ENSG00000156482.10	RPL30	8	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P27824	Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2	0	46.408	29	16	32	16	592	67.5	4.6			7	14			7	25	75642.96875	1214772.117	13584258.52	53453044	1	5	15	16		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;membrane;organelle lumen;ribosome	metal ion binding;protein binding;RNA binding	Pf00262	821	ENSG00000127022.14; ENSG00000283777.1	CANX	5; CHR_HG30_PATCH	"Assembly of Viral Components at the Budding Site; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Calnexin/calreticulin cycle; MHC class II antigen presentation"	Protein processing in endoplasmic reticulum; HTLV-I infection; Phagosome; Thyroid hormone synthesis; Antigen processing and presentation	0
High	P62277	40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2	0	19.638	45	7	31	7	151	17.2	10.54	4	4	5	7	7	7	7	10	8828602.438	15141613.69	16588354.69	14907731.09	5	6	6	6		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00312, Pf08069"	6207	ENSG00000110700.6	RPS13	11	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P43243	Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2	0	29.207	18	12	31	12	847	94.6	6.25	8	9	7	5	8	10	7	6	5790160.719	4838111.789	4957196.516	5417690.641	10	10	10	10		defense response;regulation of biological process;response to stimulus	membrane;nucleus	metal ion binding;protein binding;RNA binding;structural molecule activity	"Pf00076, Pf13893, Pf14259"	9782	ENSG00000015479.18; ENSG00000280987.4	MATR3	5			0
High	Q9UKT8	F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2	0	47.974	28	11	31	11	454	51.5	6.58		7	9	10		10	10	11	67874.30469	12122365.41	15689475.72	16934611.72	1	9	11	10		metabolic process	cytosol	catalytic activity;protein binding	Pf00400	26190	ENSG00000119402.16	FBXW2	9	Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation		0
High	P16989	Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4	0	32.966	37	9	31	5	372	40.1	9.77	4	7	5	8	4	9	7	11	2739361.188	4992289.469	3941336.844	2812165.719	5	5	5	4		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	DNA binding;protein binding;RNA binding	Pf00313	8531	ENSG00000060138.12	CSDA; YBX3	12		Tight junction	0
High	Q15369	Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1	0	33.905	66	8	31	8	112	12.5	4.78	4	4	6	7	7	6	7	11	10915046.97	10284712.66	14054660.94	20726813.31	6	7	8	8		metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;protein binding;RNA binding	Pf03931	6921	ENSG00000154582.16	TCEB1; ELOC	8	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-7 signaling; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of Tat-mediated HIV elongation	HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma	0
High	P62750	60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1	0	18.207	44	7	31	7	156	17.7	10.45	6	6	6	4	9	9	7	6	6618439.125	11523446.59	12579080.38	10361357.19	6	6	6	6		cell organization and biogenesis;cell proliferation;metabolic process;transport	cytoplasm;cytosol;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00276, Pf03939"	6147	ENSG00000198242.13	RPL23A	17	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1	0	60.901	30	15	30	15	607	68.5	6.38		1	12	11		1	13	16	246001.332	510044.0313	17332106.19	26075204.13	3	3	13	12		metabolic process	cytosol;endoplasmic reticulum;membrane	catalytic activity;protein binding;RNA binding	Pf04597	6184	ENSG00000163902.11	RPN1	3	Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane	N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	P14868	"Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2"	0	32.334	29	12	30	12	501	57.1	6.55	7	8	7	7	7	8	7	8	4047181.313	4727902.219	5605813.313	5227315.75	10	10	11	10		cell organization and biogenesis;metabolic process	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00152, Pf01336"	1615	ENSG00000115866.10	DARS	2	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Aminoacyl-tRNA biosynthesis	0
High	Q01844	RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1	0	33.319	11	7	30	7	656	68.4	9.33	5	6	4	7	6	9	4	11	10385392.86	11487241.78	9646472.938	14277197.91	7	7	7	7		metabolic process;regulation of biological process	cytoplasm;membrane;nucleus	metal ion binding;protein binding;RNA binding	"Pf00076, Pf00641, Pf14259"	2130	ENSG00000182944.17	EWSR1	22		Transcriptional misregulation in cancer	0
High	P18124	60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1	0	20.961	28	7	30	7	248	29.2	10.65	5	6	6	6	5	9	9	7	9131842.75	12183330.97	17732138.31	12385965.13	7	7	7	7		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	DNA binding;protein binding;RNA binding;structural molecule activity	"Pf00327, Pf08079"	6129	ENSG00000147604.13	RPL7	8	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q96JN8	Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2	0	40.8	10	13	29	13	1562	166.8	5.86	4	12	7	4	4	14	7	4	2822918.125	13553270.03	7722004.156	4599705.859	7	12	10	9			cytoplasm;cytoskeleton	protein binding	Pf07177	84461	ENSG00000215041.9	NEURL4	17			0
High	Q99878	Histone H2A type 1-J OS=Homo sapiens OX=9606 GN=H2AC14 PE=1 SV=3	0	21.706	41	6	29	4	128	13.9	10.89	2	5	6	4	4	10	9	6	12763136.61	31435916.63	30639250.31	20835752.63	6	6	6	6		regulation of biological process	chromosome;nucleus	DNA binding;protein binding	"Pf00125, Pf00808"	8331; 8330	ENSG00000276368.1	HIST1H2AJ; HIST1H2AK	6	SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence	Systemic lupus erythematosus; Alcoholism	2
High	Q99729	Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2	0	21.405	22	7	29	6	332	36.2	8.21	4	5	6	5	6	7	9	7	14171641.45	26289601.38	18702415.52	20991170.69	5	7	7	7		cell organization and biogenesis;regulation of biological process	cytoplasm;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf08143, Pf13893, Pf14259"	3182		HNRNPAB	5			1
High	Q9UL18	Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3	0	27.54	14	10	29	6	857	97.2	9.16	8	6	4	6	12	7	4	6	3433393.906	3764733.813	1884617.734	2983889.531	6	6	5	5		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;protein binding;RNA binding	"Pf02170, Pf02171, Pf08699"	26523	ENSG00000092847.11	AGO1; EIF2C1	1	Post-transcriptional silencing by small RNAs; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence		0
High	Q15365	Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2	0	21.056	30	7	29	4	356	37.5	7.09	6	5	5	6	7	7	8	7	3302310.469	5817566.719	4174791.156	5080663.344	3	4	4	4		metabolic process;regulation of biological process	cytoplasm;cytosol;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00013, Pf13014"	5093	ENSG00000169564.6	PCBP1	2	mRNA Splicing - Major Pathway	Spliceosome	0
High	P31040	"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2"	0	32.087	22	12	28	12	664	72.6	7.39	6	10	5	6	6	11	5	6	5730247.188	5772310.719	5076776.469	7881802.141	8	10	10	11		metabolic process;transport	membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding	"Pf00890, Pf02910"	6389	ENSG00000073578.16	SDHA	5	Respiratory electron transport; Citric acid cycle (TCA cycle)	Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways	0
High	P07814	Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5	0	38.412	11	13	28	13	1512	170.5	7.33	7	6	8	7	7	6	8	7	5759368.188	4238547.656	4372328.469	6479148.438	11	10	10	10		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497"	2058	ENSG00000136628.17	EPRS	1	tRNA modification in the nucleus and cytosol; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Porphyrin and chlorophyll metabolism; Aminoacyl-tRNA biosynthesis; Metabolic pathways	0
High	Q9NV79	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCMTD2 PE=1 SV=2	0	19.23	27	8	28	8	361	41	6.11	7	5	4	5	11	5	5	7	10189935.75	5328305.469	6842748.313	10481581.25	7	7	7	7		metabolic process	cytoplasm	catalytic activity	"Pf01135, Pf08242, Pf12847, Pf13847"	55251	ENSG00000280663.4; ENSG00000203880.11	PCMTD2	20; CHR_HSCHR20_1_CTG3			0
High	P33993	DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4	0	42.204	21	11	28	11	719	81.3	6.46	2	5	8	9	2	5	9	12	1624895.547	2906277.641	7221753.531	12814574.97	7	9	9	11	Met-loss+Acetyl [N-Term]	cell proliferation;metabolic process;regulation of biological process;response to stimulus	chromosome;cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00493, Pf07728, Pf14551"	4176	ENSG00000166508.17	MCM7	7	M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins	DNA replication; Cell cycle	0
High	P11586	"C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3"	0	21.72	13	10	28	10	935	101.5	7.3	6	4	5	8	10	4	6	8	4477467.266	4461153.203	6301017.797	9228717.375	10	9	10	10		metabolic process	cytoplasm;cytosol;membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding	"Pf00763, Pf01268, Pf02882"	4522		MTHFD1	14	Metabolism of folate and pterines	One carbon pool by folate; Metabolic pathways	0
High	P34896	"Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1"	0	47.123	38	15	28	14	483	53	7.71	15		1	1	26		1	1	30892114.69	2047666.813	3631686.965	3418274.703	14	2	6	5		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;mitochondrion;nucleus	catalytic activity;protein binding;RNA binding;translation regulator activity	Pf00464	6470	ENSG00000176974.19	SHMT1	17	Metabolism of folate and pterines; Carnitine synthesis	"Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism"	1
High	O14979	Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3	0	18.353	20	6	28	5	420	46.4	9.57	4	5	5	4	6	8	8	6	3062302.188	6325493.594	4629866.156	4473964.469	4	4	5	4		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00076, Pf08777, Pf13893, Pf14259"	9987	ENSG00000152795.17	HNRNPDL; HNRPDL	4	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling		0
High	Q9BYP7	Serine/threonine-protein kinase WNK3 OS=Homo sapiens OX=9606 GN=WNK3 PE=1 SV=3	0	37.985	13	17	27	17	1800	198.3	6.07		16	9			18	9		138301.9219	11702921.58	6476376.656	378669.1484	1	14	13	3		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf07714, Pf12202"	65267	ENSG00000196632.10	WNK3	X	Stimuli-sensing channels		0
High	Q96RR1	"Twinkle protein, mitochondrial OS=Homo sapiens OX=9606 GN=TWNK PE=1 SV=1"	0	40.718	21	11	27	11	684	77.1	8.98		11	7	4		15	8	4	73461.04688	12117587.39	8043139.859	3350535.891	1	9	9	7		cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus	mitochondrion;organelle lumen	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf03796, Pf13401, Pf13476, Pf13481"	56652	ENSG00000107815.7	C10orf2; TWNK	10	Transcriptional activation of mitochondrial biogenesis		0
High	P50914	60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4	0	13.745	24	5	27	5	215	23.4	10.93	4	5	5	5	7	6	8	6	11002442.94	13941810.56	16354663	14478072	5	5	5	5		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01929	9045	ENSG00000188846.13	RPL14	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P18621	60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3	0	35.862	47	7	27	7	184	21.4	10.17	6	5	4	5	7	7	6	7	12795148.53	19621030.41	18190558.69	15206177.41	6	6	6	6		cell organization and biogenesis;metabolic process;transport	cytosol;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf00237	6139	ENSG00000215472.10; ENSG00000265681.7	RPL17	18	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P62910	60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2	0	20.252	35	5	27	5	135	15.9	11.33	4	4	5	4	6	6	9	6	7081806.625	10277716.88	12932004.44	13922293.25	5	5	5	5		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytosol;membrane;ribosome	RNA binding;structural molecule activity	Pf01655	6161	ENSG00000144713.12	RPL32	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P61513	60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2	0	19.075	41	3	27	3	92	10.3	10.43	3	3	3	3	7	7	7	6	12503615.81	9979662.125	11842953.53	11065231.94	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytosol;nucleus;ribosome	metal ion binding;protein binding;RNA binding;structural molecule activity	Pf01780	6168	ENSG00000197756.9	RPL37A	2	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P18077	60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2	0	11.951	44	6	27	6	110	12.5	11.06	3	4	5	5	5	7	8	7	5392502.438	9014364.156	11502576.97	9093758.063	6	6	6	6		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01247	6165	ENSG00000182899.14	RPL35A	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P06748	Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2	0	39.931	53	11	27	11	294	32.6	4.78	4	3	11	5	5	3	14	5	15028337.84	18988253.59	50089127.44	29107959.56	9	10	11	10	Acetyl [N-Term]	cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	DNA binding;enzyme regulator activity;protein binding;RNA binding	Pf03066	4869	ENSG00000181163.13	NPM1	5	Nuclear import of Rev protein; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deposition of new CENPA-containing nucleosomes at the centromere		0
High	Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2	0	21.533	18	10	27	7	515	58.2	9.25	7	7	4	5	9	8	4	6	9692360.188	3088565.578	2021304.328	4504559	7	6	5	6		cell organization and biogenesis;regulation of biological process;response to stimulus	nucleus	protein binding;structural molecule activity	"Pf02084, Pf02201"	6602	ENSG00000066117.14	SMARCD1	12	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		0
High	P62244	40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2	0	25.02	59	7	26	7	130	14.8	10.13	3	6	5	7	4	7	6	9	6927099.906	11393197.31	15220768.39	24308428.25	6	9	8	9		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;ribosome	protein binding;RNA binding;structural molecule activity	Pf00410	6210	ENSG00000134419.15	RPS15A	16	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P10412	Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2	0	23.518	32	8	26	2	219	21.9	11.03	4	5	5	8	4	6	6	10	9048193.844	16263112.5	18486198.03	16585570.66	7	7	7	7	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process	chromosome;nucleus	DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	Pf00538	3008	ENSG00000168298.6	HIST1H1E	6	Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor		6
High	P61254	60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1	0	12.959	32	7	26	7	145	17.2	10.55	4	5	7	3	6	8	8	4	10904091.31	16582948.06	16354444.44	14233483	6	7	7	7		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00467	6154	ENSG00000161970.12	RPL26	17	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q9NZC9	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1	0	38.234	13	12	26	12	954	105.9	9.06		10	10	3		11	11	4	44389.9375	10726618.83	9712320.5	5429560.563	1	12	12	11		metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00176, Pf00270, Pf00271, Pf07443"	50485	ENSG00000138375.12	SMARCAL1	2			0
High	P62913	60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2	0	13.845	28	4	26	4	178	20.2	9.6	3	4	3	3	5	7	6	8	8583208.938	13307234.31	15591190.75	12944499.88	4	4	3	3	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00281, Pf00673"	6135	ENSG00000142676.12	RPL11	1	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P62263	40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3	0	28.307	33	6	26	6	151	16.3	10.05	3	5	6	5	4	6	8	8	4004682.875	7655077.109	9832159.094	11941235.56	6	6	5	5		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;mitochondrion;ribosome	protein binding;RNA binding;structural molecule activity;translation regulator activity	Pf00411	6208	ENSG00000164587.11	RPS14	5	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P01889	"HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3"	0	49.464	36	11	25	6	362	40.4	5.85				11				25		486485.75	1084720.492	24928174		4	4	6		regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;Golgi;membrane	protein binding	"Pf00129, Pf06623, Pf07654"	3106	ENSG00000234745.10	HLA-B	6	"Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC"	Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity; HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation	1
High	Q5M9Q1	NKAP-like protein OS=Homo sapiens OX=9606 GN=NKAPL PE=1 SV=3	0	11.912	11	5	25	1	402	46.3	9.72	4	4	4	4	6	6	6	7										cell differentiation;metabolic process;regulation of biological process;response to stimulus	nucleus		Pf06047	222698	ENSG00000189134.3	NKAPL	6			0
High	O94898	Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens OX=9606 GN=LRIG2 PE=2 SV=3	0	40.138	17	13	25	11	1065	118.9	5.55			6	13			7	18	270215.7188	192035.7969	5325789.113	13897081.14	1	1	12	13		regulation of biological process	cytoplasm;membrane	protein binding	"Pf00047, Pf07679, Pf07686, Pf12799, Pf13306, Pf13855, Pf13895, Pf13927"	9860	ENSG00000198799.11	LRIG2	1			2
High	P62805	Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2	0	21.907	52	7	25	7	103	11.4	11.36	3	7	4	2	3	11	8	3	3028373.344	21710130.56	17332341.97	11875751.47	4	6	6	4		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;extracellular;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00125, Pf02969, Pf15630"	8359; 8361; 8360; 8363; 8370; 554313; 8365; 8364; 121504; 8367; 8294; 8366; 8362; 8368	ENSG00000197061.4; ENSG00000275126.1; ENSG00000273542.1; ENSG00000197238.4; ENSG00000197837.3; ENSG00000276966.2; ENSG00000158406.4; ENSG00000270882.2; ENSG00000274618.1; ENSG00000278637.1; ENSG00000277157.1; ENSG00000278705.1; ENSG00000270276.2; ENSG00000276180.1	HIST1H4A; HIST1H4F; HIST1H4D; HIST1H4J; HIST2H4A; HIST2H4B; HIST1H4H; HIST1H4C; HIST4H4; HIST1H4E; HIST1H4I; HIST1H4B; HIST1H4K; HIST1H4L	6; 1; 12	SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of chromatin organization proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence	Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism	0
High	O15078	Centrosomal protein of 290 kDa OS=Homo sapiens OX=9606 GN=CEP290 PE=1 SV=2	0	41.252	8	19	25	19	2479	290.2	5.95		17	5	3		17	5	3	553363.1133	6969042.031	3551967.297	3034208.328	4	18	14	12		cell organization and biogenesis;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	protein binding		80184	ENSG00000198707.14	CEP290	12	Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes		0
High	Q96PK6	RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2	0	29.198	19	10	25	10	669	69.4	9.67	5	7	5	8	5	7	5	8	4877176.109	6468395.469	6522272.203	8129130.656	10	10	10	10		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10432; 100526737	ENSG00000239306.4	RBM14; RBM14-RBM4	11	RUNX2 regulates bone development		0
High	P40429	60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2	0	16.21	31	7	25	7	203	23.6	10.93	4	6	5	5	5	8	6	6	9698871.375	13689468.88	15787348.81	11611889.75	6	6	6	6	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	RNA binding;structural molecule activity	Pf00572	23521	ENSG00000142541.16	RPL13A	19	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q12906	Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3	0	23.568	12	9	24	9	894	95.3	8.76	5	5	5	4	6	7	6	5	9074095.313	10081142	12379552.06	10084185.72	8	7	7	7		defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;extracellular;membrane;mitochondrion;nucleus	DNA binding;protein binding;RNA binding	"Pf00035, Pf07528, Pf14709"	3609	ENSG00000129351.17	ILF3	19			0
High	P98160	Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4	0	20.324	3	9	24	9	4391	468.5	6.51	8	6	4	6	8	6	4	6	2746043.547	3381576.156	1745491.938	2069354	9	9	6	6		cell differentiation;cell growth;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	metal ion binding;protein binding	"Pf00008, Pf00047, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf07686, Pf12785, Pf13385, Pf13895, Pf13927"	3339	ENSG00000142798.17	HSPG2	1	"Integrin cell surface interactions; Defective B4GALT7 causes EDS, progeroid type; Amyloid fiber formation; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Non-integrin membrane-ECM interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD"	Hepatitis B; Proteoglycans in cancer; ECM-receptor interaction	0
High	P61313	60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2	0	15.095	32	6	24	6	204	24.1	11.62	4	3	5	4	6	5	7	6	6829936.5	8914575.063	14904142.09	12049160.88	5	4	6	5		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf00827	6138	ENSG00000174748.18	RPL15	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q8IWF2	FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FOXRED2 PE=1 SV=1	0	38.376	23	12	23	12	684	77.7	7.72			7	12			8	15	218376.7109	545929.5547	8945155.25	16722156.69	2	2	11	11		metabolic process	endoplasmic reticulum;organelle lumen	catalytic activity;nucleotide binding;protein binding	"Pf01266, Pf01946, Pf03486, Pf07992, Pf13450, Pf13738"	80020	ENSG00000100350.14	FOXRED2	22			0
High	P48047	"ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1"	0	23.207	46	7	23	7	213	23.3	9.96	5	3	6	3	6	4	9	4	4116376.5	4318229.125	7479363.375	5501232.781	5	5	5	5		cell organization and biogenesis;metabolic process;transport	membrane;mitochondrion;nucleus	catalytic activity;protein binding;transporter activity	Pf00213	539	ENSG00000241837.6	ATP5O	21	Cristae formation; Formation of ATP by chemiosmotic coupling	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways	0
High	Q8IZD2	Inactive histone-lysine N-methyltransferase 2E OS=Homo sapiens OX=9606 GN=KMT2E PE=1 SV=1	0	40.965	12	15	23	15	1858	204.8	7.61		2	13	8		2	13	8	369742.5391	6346881.809	10991343.47	4876968.953	3	12	13	12		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;membrane;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00628, Pf00856, Pf07223, Pf09770"	55904	ENSG00000005483.20	KMT2E; MLL5	7	PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Lysine degradation	0
High	Q13310	Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1	0	37.565	23	14	23	6	644	70.7	9.26	11	1	6	5	11	1	6	5	3237696.047	1441115.453	1695746.063	2463356.5	6	4	5	5		coagulation;metabolic process	cytoplasm;cytosol;nucleus	protein binding;RNA binding	"Pf00076, Pf00658, Pf13893, Pf14259"	8761	ENSG00000090621.13	PABPC4	1		RNA degradation; mRNA surveillance pathway; RNA transport	0
High	Q71UI9	Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3	0	8.592	23	3	22	1	128	13.5	10.58	2	3	3	3	4	6	6	6	509324.7188	666301.8125	709900.125	726390.1875	1	1	1	1		regulation of biological process	chromosome;nucleus	DNA binding;protein binding	Pf00125	94239	ENSG00000105968.18	H2AFV	7	SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Packaging Of Telomere Ends; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening	Systemic lupus erythematosus; Alcoholism	0
High	Q99615	DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2	0	37.186	26	12	22	12	494	56.4	6.96			9	10			11	11	1860411.004	9045619.961	16076950.11	24007310.81	3	3	9	11		metabolic process;regulation of biological process	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	enzyme regulator activity;protein binding	"Pf00226, Pf00515, Pf07719, Pf13414, Pf13424, Pf13431, Pf13432"	7266	ENSG00000168259.14	DNAJC7	17	Regulation of HSF1-mediated heat shock response		0
High	P16403	Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2	0	20.376	28	7	22	1	213	21.4	10.93	3	3	5	6	3	4	7	8	633053.4375	1178163.875	1687378	1603543.375	1	1	1	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process	chromosome;nucleus	DNA binding;protein binding;RNA binding	Pf00538	3006	ENSG00000187837.3	HIST1H1C	6	Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor		0
High	Q2M1P5	Kinesin-like protein KIF7 OS=Homo sapiens OX=9606 GN=KIF7 PE=1 SV=2	0	32.891	15	13	22	13	1343	150.5	6.79	1	4	5	9	1	6	6	9	558592113.4	584276332.7	486150086.9	804814682.1	10	10	13	12		cellular component movement;metabolic process;regulation of biological process	cytoplasm;cytoskeleton	catalytic activity;motor activity;nucleotide binding;protein binding	"Pf00225, Pf04111"	374654	ENSG00000166813.14	KIF7	15	Hedgehog 'on' state; Hedgehog 'off' state	Hedgehog signaling pathway	0
High	P62847	40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1	0	15.116	24	4	22	4	133	15.4	10.78	3	4	4	3	3	7	7	5	2091225.344	3056790.813	3391820.813	2786171.719	4	4	4	4	Acetyl [N-Term]	cell organization and biogenesis;metabolic process;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01282	6229	ENSG00000138326.18	RPS24	10	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P54132	Bloom syndrome protein OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1	0	31.418	13	13	21	13	1417	158.9	7.49		7	10	4		7	10	4	2920120.676	4254363.859	5126685.719	2832596.016	3	8	10	9		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf00270, Pf00271, Pf00570, Pf08072, Pf09382"	641	ENSG00000197299.10	BLM	15	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates	Homologous recombination; Fanconi anemia pathway	0
High	Q969G3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2	0	30.833	22	7	21	7	411	46.6	4.88	6	4	4	4	9	4	4	4	12447058.31	8794338.172	6960879	13572988.22	6	6	6	6		cell differentiation;cell organization and biogenesis;regulation of biological process	chromosome;nucleus	catalytic activity;DNA binding;protein binding;RNA binding	Pf00505	6605	ENSG00000073584.18	SMARCE1	17	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		0
High	P26373	60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4	0	15.977	25	5	21	5	211	24.2	11.65	2	5	5	4	2	6	7	6	8878390.5	10840269.16	12626735.31	10952485.56	5	5	5	5		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01294	6137	ENSG00000167526.13	RPL13	16	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P07900	Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5	0	35.01	17	12	21	2	732	84.6	5.02	2	4	9	5	2	4	10	5	251777.7031	595596.3594	1325888.406	2156893.063	1	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding	"Pf00183, Pf02518, Pf13589"	3320	ENSG00000080824.18	HSP90AA1	14	"Sema3A PAK dependent Axon repulsion; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Scavenging by Class F Receptors; Neutrophil degranulation; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); vRNP Assembly; Downregulation of ERBB2 signaling; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Constitutive Signaling by EGFRvIII; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; Attenuation phase; eNOS activation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; VEGFR2 mediated vascular permeability; PIWI-interacting RNA (piRNA) biogenesis; Interleukin-4 and 13 signaling"	NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; PI3K-Akt signaling pathway; Antigen processing and presentation	0
High	Q13247	Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2	0	13.121	15	6	21	6	344	39.6	11.43	6	5	3	3	7	7	3	4	4684766.227	5685048.539	5124234.078	5277241.93	6	6	6	5		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	nucleus	protein binding;RNA binding	"Pf00076, Pf08777, Pf13893, Pf14259"	6431	ENSG00000124193.14	SRSF6	20	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome; Herpes simplex infection	0
High	Q07021	"Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1"	0	24.379	21	3	20	3	282	31.3	4.84	1	3	3	2	1	8	6	5	1285316.453	4044276.875	3808763.875	5222340.063	3	3	3	3		cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen	protein binding;RNA binding	Pf02330	708	ENSG00000108561.8	C1QBP	17	Intrinsic Pathway of Fibrin Clot Formation	Herpes simplex infection	0
High	Q9HCJ0	Trinucleotide repeat-containing gene 6C protein OS=Homo sapiens OX=9606 GN=TNRC6C PE=1 SV=3	0	15.171	5	6	20	5	1690	175.9	6.96	4	2	5	5	6	2	6	6	2105837.922	1321415.477	2012154.156	2093252.188	5	5	4	4		regulation of biological process;response to stimulus	cytosol	protein binding;RNA binding	"Pf00076, Pf00627, Pf10427, Pf12938, Pf13893, Pf14259"	57690	ENSG00000078687.17	TNRC6C	17	Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence		0
High	P46777	60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3	0	18.589	19	4	20	4	297	34.3	9.72	3	4	3	3	4	7	6	3	5220552.875	9158393	8665517.688	7460483	4	4	4	4		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00861, Pf14204"	6125	ENSG00000122406.12	RPL5	1	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q8TEM1	Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3	0	42.068	10	15	20	15	1887	205	6.81			5	14			5	15	1260844.156	392657.1172	4307184.621	12391347.8	4	4	10	12		cell organization and biogenesis;metabolic process;regulation of biological process;transport	endoplasmic reticulum;membrane;nucleus	protein binding	Pf02368	23225	ENSG00000132182.11	NUP210	3	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	Q16778	Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3	0	17.576	40	5	20	1	126	13.9	10.32	3	5	4	4	3	7	6	4	634661.8125	1946052.125	1952393.5	1468955.75	1	1	1	1		cell organization and biogenesis;defense response;response to stimulus	chromosome;cytosol;nucleus	DNA binding;protein binding	"Pf00125, Pf00808"	8349	ENSG00000184678.10	HIST2H2BE	1	SIRT1 negatively regulates rRNA expression; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence	Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism	0
High	P39019	40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2	0	18.132	43	7	20	7	145	16.1	10.32	3	6	3	5	3	7	4	6	5645730.141	8411088.25	10091133.16	6461617.531	7	7	7	6		cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01090	6223	ENSG00000105372.6	RPS19	19	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q92888	Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2	0	26.455	10	10	20	10	912	102.4	5.66		6	3	7		8	3	9	73686.49023	5680511.297	2154147.047	7603921.625	2	9	6	9		cell proliferation;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	enzyme regulator activity;protein binding;RNA binding	"Pf00621, Pf09128"	9138	ENSG00000076928.17	ARHGEF1	19	G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle	Vascular smooth muscle contraction; Pathways in cancer; Proteoglycans in cancer; Regulation of actin cytoskeleton; Platelet activation	0
High	P04439	"HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2"	0	27.318	19	6	20	1	365	40.8	6	1		1	6	1		1	18			299553.25	5892006.5			1	1		metabolic process;regulation of biological process;response to stimulus	cell surface;endoplasmic reticulum;Golgi;membrane	protein binding;RNA binding	"Pf00129, Pf07654"	3105	ENSG00000206503.12	HLA-A	6	"Interferon alpha/beta signaling; E3 ubiquitin ligases ubiquitinate target proteins; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway"		0
High	P46776	60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2	0	15.367	32	6	20	6	148	16.6	11	5	3	3	3	6	4	6	4	12827735.31	20460255.41	14578050.64	13813759.8	5	5	5	4		cell organization and biogenesis;metabolic process;transport	cytosol;endoplasmic reticulum;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00828	6157	ENSG00000166441.12	RPL27A	11	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P28288	ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1	0	32.146	27	13	20	13	659	75.4	9.36			10	8			12	8	89496.24219	3191541.734	12622455.33	9218536.766	1	5	12	12		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytosol;membrane;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding;transporter activity	"Pf00005, Pf06472"	5825	ENSG00000117528.11	ABCD3	1	ABC transporters in lipid homeostasis	Peroxisome; ABC transporters	0
High	Q96KG9	N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1	0	30.005	16	11	20	11	808	89.6	6.3		11	4			15	5		258627.2539	13682419.75	6004657.008	1276146.555	3	10	9	5		metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00069, Pf07714"	57410	ENSG00000142186.16	SCYL1	11			0
High	Q5SNT2	Transmembrane protein 201 OS=Homo sapiens OX=9606 GN=TMEM201 PE=1 SV=1	0	22.062	14	8	20	8	666	72.2	9.22			8	6			12	8		149480.3477	20075166.66	9218065.344		2	8	7	Acetyl [N-Term]	cell organization and biogenesis;cellular component movement	cytoplasm;cytoskeleton;membrane;nucleus	protein binding	"Pf09779, Pf10476"	199953	ENSG00000188807.12	TMEM201	1			0
High	Q12905	Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2	0	31.546	25	7	20	7	390	43	5.26	4	6	4	2	6	7	4	3	4540207.906	5392417.547	6887325.563	6497130.313	6	6	6	6		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;membrane;nucleus;organelle lumen	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	Pf07528	3608	ENSG00000143621.16	ILF2	1	Neutrophil degranulation		0
High	P0C2W1	F-box/SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FBXO45 PE=1 SV=1	0	18.981	34	7	20	7	286	30.6	7.83		5	5	6		6	6	8	70088.42188	9615927	14938366.13	15900415	1	6	6	6	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;development;metabolic process;response to stimulus	membrane	protein binding	"Pf00622, Pf00646, Pf12937"	200933	ENSG00000174013.7	FBXO45	3			0
High	Q96AG4	Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1	0	26.56	32	8	20	8	307	34.9	9.57	3	5	4	6	3	5	5	7	6833915.813	7417443	11012579.94	8825569.313	7	7	7	6			endoplasmic reticulum;membrane;nucleus	protein binding;RNA binding	"Pf12799, Pf13855"	55379	ENSG00000108829.9	LRRC59	17			0
High	Q13472	DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1	0	24.929	12	11	19	11	1001	112.3	8.34		9	5	4		10	5	4	141538.9531	7132503.781	5863099.211	3969070.563	1	11	11	8		metabolic process;regulation of biological process	chromosome;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding	"Pf01131, Pf01396, Pf01751, Pf06839"	7156	ENSG00000177302.14; ENSG00000284238.1	TOP3A	17; CHR_HSCHR17_3_CTG1	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates	Homologous recombination; Fanconi anemia pathway	0
High	P38159	"RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3"	0	10.915	11	5	19	5	391	42.3	10.05	2	5	4	2	2	8	6	3	5820839.563	7823365.313	5754662.188	4507227.813	5	5	5	4		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00076, Pf08081, Pf13893, Pf14259"	27316	ENSG00000147274.14	RBMX	X	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q9UMS4	Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1	0	15.394	18	6	19	6	504	55.1	6.61	3	4	4	3	5	6	5	3	3063471.719	3888162.969	3217441.938	4791798.375	5	5	5	5	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex	catalytic activity;metal ion binding;protein binding	"Pf00400, Pf04564, Pf08606, Pf11789"	27339	ENSG00000110107.8	PRPF19	11	Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER	Ubiquitin mediated proteolysis; Spliceosome	0
High	P37198	Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3	0	34.836	25	8	19	8	522	53.2	5.31		7	6	5		8	6	5	1323276.938	7882053.625	7092162.203	4934521.5	3	6	7	5	Met-loss+Acetyl [N-Term]	cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;membrane;nucleus	protein binding;structural molecule activity;transporter activity	Pf05064	23636	ENSG00000213024.11	NUP62	19	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	P25398	40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3	0	26.808	58	5	19	5	132	14.5	7.21	3	2	5	4	3	3	7	6	2189644.164	3238541.781	4820304.188	4156116.125	5	5	5	5	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;ribosome	RNA binding;structural molecule activity	Pf01248	6206	ENSG00000112306.7	RPS12	6	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	O43143	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2	0	18.343	8	6	19	6	795	90.9	7.46	3	3	3	4	3	5	6	5	2621449.531	2892493.688	4491766.281	6519909.813	4	4	4	5		metabolic process;response to stimulus	cytoplasm;nucleus;spliceosomal complex	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf04408, Pf07717, Pf13401"	1665	ENSG00000109606.12	DHX15	4	mRNA Splicing - Major Pathway	Spliceosome	0
High	P49916	DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2	0	23.262	12	9	19	9	1009	112.8	9.01		9	3	2		13	3	3	380873.7188	7127008.156	3115483.234	3349416.563	1	10	8	7		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	mitochondrion;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf00645, Pf01068, Pf04675, Pf04679"	3980	ENSG00000005156.11	LIG3	17	Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER	Base excision repair	0
High	P38435	Vitamin K-dependent gamma-carboxylase OS=Homo sapiens OX=9606 GN=GGCX PE=1 SV=2	0	24.606	12	8	19	8	758	87.5	8.02		5	8	2		6	10	3		8406611.5	13657159.38	4338352.297		7	7	7	Met-loss+Acetyl [N-Term]	coagulation;metabolic process	endoplasmic reticulum;membrane	catalytic activity	Pf05090	2677	ENSG00000115486.11	GGCX	2	Gamma-carboxylation of protein precursors	Ubiquinone and other terpenoid-quinone biosynthesis	0
High	Q96I24	Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2	0	17.321	15	7	19	7	572	61.6	8.38	5	5	3	4	5	6	3	5	1931645.406	2991633.844	2182650.781	2247000.359	7	7	7	7		metabolic process;regulation of biological process	cytoplasm;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00013, Pf07650, Pf13014"	8939	ENSG00000107164.15	FUBP3	9			0
High	P62266	40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3	0	7.919	22	3	19	3	143	15.8	10.49	3	3	3	3	5	4	5	5	6049636.25	8290883	8623777.125	7578595.25	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00164	6228	ENSG00000186468.12	RPS23	5	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P42677	40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3	0	12.337	30	3	18	3	84	9.5	9.45	1	3	3	3	1	5	5	7	989344.0625	4829786.125	6794212.313	15228318.25	2	3	3	3		cell organization and biogenesis;cell proliferation;metabolic process;transport	cytosol;nucleus;ribosome	DNA binding;metal ion binding;protein binding;RNA binding;structural molecule activity	Pf01667	6232	ENSG00000177954.11	RPS27	1	"Peptide chain elongation; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Separation of Sister Chromatids; SRP-dependent cotranslational protein targeting to membrane; Eukaryotic Translation Termination; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; Major pathway of rRNA processing in the nucleolus and cytosol; RHO GTPases Activate Formins; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits"	Ribosome	0
High	O75643	U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2	0	19.807	4	9	18	9	2136	244.4	6.06	3	3	6	5	3	3	7	5	2453558.375	3162528.219	3535622.789	4584946.297	7	7	8	8		cell differentiation;cell organization and biogenesis;metabolic process	membrane;nucleus;spliceosomal complex	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf02889, Pf04851"	23020	ENSG00000144028.14	SNRNP200	2	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	P05023	Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1	0	26.345	10	8	18	8	1023	112.8	5.49		1	6	8		1	8	9	616599.666	1895851.039	5250888.406	9115715.031	5	6	8	8		cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;endosome;Golgi;membrane	catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity	"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246"	476	ENSG00000163399.15	ATP1A1	1	Ion homeostasis; Ion transport by P-type ATPases	Bile secretion; cGMP-PKG signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Protein digestion and absorption; Proximal tubule bicarbonate reclamation; Thyroid hormone signaling pathway; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Pancreatic secretion; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Gastric acid secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Mineral absorption	0
High	Q15717	ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2	0	15.4	19	6	18	6	326	36.1	9.17	4	5	4	2	6	6	4	2	3529885.938	5157809.813	4894672.188	5703766.188	4	4	4	4		development;metabolic process;regulation of biological process	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	1994	ENSG00000066044.14	ELAVL1	19	HuR (ELAVL1) binds and stabilizes mRNA; mRNA Splicing - Major Pathway	AMPK signaling pathway	0
High	P84103	Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1	0	10.188	34	4	18	4	164	19.3	11.65	3	4	3	3	4	6	4	4	2429460.313	4004526.313	4122487.938	4115096.188	3	3	3	3		metabolic process;regulation of biological process;transport	cytoplasm;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	6428	ENSG00000112081.16	SRSF3	6	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway	Spliceosome; Herpes simplex infection	0
High	P32119	Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5	0	9.245	15	3	18	2	198	21.9	5.97	3	3	2	2	5	6	4	3	1585632.5	1638884.5	1968039.875	1812032.313	2	2	2	2		cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	antioxidant activity;catalytic activity;protein binding	"Pf00578, Pf08534, Pf10417"	7001	ENSG00000167815.11	PRDX2	19	TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species		0
High	Q7L014	Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2	0	19.648	8	9	18	9	1031	117.3	9.29	4	4	5	4	5	4	5	4	2286715.641	4157371.906	4894730.766	3257185.391	7	8	9	7		metabolic process;regulation of biological process	cytoplasm;membrane;nucleus	catalytic activity;nucleotide binding;RNA binding	"Pf00270, Pf00271"	9879	ENSG00000145833.15	DDX46	5	mRNA Splicing - Major Pathway	Spliceosome	0
High	P17987	T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1	0	28.583	19	10	18	10	556	60.3	6.11		1	5	9		1	5	12	5836332.875	4926488	7489561.781	14361222.81	7	7	10	10	Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;Golgi	nucleotide binding;protein binding;RNA binding	Pf00118	6950	ENSG00000120438.11	TCP1	6	BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC; Interleukin-12 family signaling		0
High	P31689	DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2	0	19.443	17	6	18	6	397	44.8	7.08	1	3	4	4	2	4	6	6	1600139.75	3509776.281	4919725.438	8151745.25	6	6	6	6		cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus	enzyme regulator activity;metal ion binding;nucleotide binding;protein binding	"Pf00226, Pf00684, Pf01556"	3301	ENSG00000086061.15	DNAJA1	9	HSP90 chaperone cycle for steroid hormone receptors (SHR)	Protein processing in endoplasmic reticulum	0
High	P46778	60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2	0	11.387	20	5	18	5	160	18.6	10.49	3	4	3	3	4	6	5	3	7951147.844	10462346	11900468.47	9509379.469	5	5	5	5		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01157	6144	ENSG00000122026.10	RPL21	13	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P26641	Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3	0	15.874	17	5	17	5	437	50.1	6.67	1	3	4	5	1	4	6	6	1670295.625	1902782.469	2395613.25	2812772.438	4	4	4	4		metabolic process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus	catalytic activity;protein binding;RNA binding	"Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497"	1937	ENSG00000254772.9	EEF1G	11	Eukaryotic Translation Elongation	Legionellosis	0
High	Q8NCA5	Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2	0	12.493	20	5	17	4	518	55.2	8.95	4	4	3	3	5	5	4	3	5424384.75	7938130.063	2876501.375	3707765.5	5	5	3	3												1
High	Q8IW35	Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1	0	23.979	15	10	17	10	865	96.9	5.02		6	10			7	10		108477.8984	3543240.5	5879204.609	462130.1641	1	8	9	3		cell organization and biogenesis;regulation of biological process	cytoplasm;cytoskeleton;cytosol	protein binding	"Pf12799, Pf13855, Pf14580"	79598	ENSG00000182504.10	CEP97	3	Anchoring of the basal body to the plasma membrane		0
High	P62081	40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1	0	14.294	41	5	17	5	194	22.1	10.1	3	4	3	4	3	5	4	5	2794379.688	3089059.875	5377079.875	7103714.75	3	3	3	4		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01251	6201	ENSG00000171863.12	RPS7	2	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P62979	Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2	0	22.164	54	7	17	2	156	18	9.64	1	5	4	5	1	5	5	6	2470438.438	6582458.375	10015878.25	11938166.63	5	6	6	6		cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	metal ion binding;protein binding;RNA binding;structural molecule activity	"Pf00240, Pf01599, Pf11976, Pf13019, Pf13881, Pf14560"	6233	ENSG00000143947.13	RPS27A	2	"NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Formation of the ternary complex, and subsequently, the 43S complex; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; Ribosomal scanning and start codon recognition; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits"	Ribosome	4
High	Q92878	DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1	0	25.539	10	11	17	11	1312	153.8	6.89	2	11	3	1	2	11	3	1	1157174.738	6298049.406	2428866.688	1949708.867	5	9	8	7		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;membrane;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf02463, Pf04423, Pf13304, Pf13476, Pf13514, Pf13555, Pf13558"	10111	ENSG00000113522.13	RAD50	5	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates	Homologous recombination; Non-homologous end-joining	0
High	O43175	D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4	0	26.351	16	6	17	6	533	56.6	6.71		2	4	6		2	6	9	771639.8926	2452621.938	3908208.438	6762915.844	2	4	6	6		metabolic process	cytosol	catalytic activity;nucleotide binding	"Pf00389, Pf02826"	26227	ENSG00000092621.11	PHGDH	1	Serine biosynthesis	"Carbon metabolism; Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways"	0
High	Q5QNW6	Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3	0	20.38	41	6	17	2	126	13.9	10.32	2	5	4	4	2	6	5	4	8763462.75	23848812	19863582.5	17368132.19	5	6	5	5		cell organization and biogenesis	chromosome;cytosol;nucleus	DNA binding;protein binding	"Pf00125, Pf00808"	440689	ENSG00000203814.6	HIST2H2BF	1	HDACs deacetylate histones; HATs acetylate histones; Ub-specific processing proteases	Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism	4
High	P0C0L4	Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2	0	20.85	4	6	17	6	1744	192.7	7.08		4	6	4		5	7	5		5718394.125	10493892.34	8795988.875		5	5	5		defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane;organelle lumen	catalytic activity;enzyme regulator activity;protein binding	"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249"	720; 721	ENSG00000244731.7	C4A; C4B	6	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5	Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Staphylococcus aureus infection	0
High	P42766	60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2	0	12.764	27	4	17	4	123	14.5	11.05	3	3	3	3	3	4	5	5	4911518.906	7178113.094	8150221.625	8911596.844	4	4	4	4		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	RNA binding;structural molecule activity	Pf00831	11224	ENSG00000136942.14	RPL35	9	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q96C24	Synaptotagmin-like protein 4 OS=Homo sapiens OX=9606 GN=SYTL4 PE=1 SV=2	0.007	1.891	1	1	17	1	671	76	8.98	1	1	1	1	4	4	4	5	206612082	126707053.9	139803203.5	140756712.8	1	1	1	1		cell organization and biogenesis;regulation of biological process;transport	cytosol;endosome;membrane	metal ion binding;protein binding	"Pf00168, Pf02318, Pf02891"	94121	ENSG00000102362.15	SYTL4	X	Platelet degranulation		0
High	Q07666	"KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1"	0	19.09	13	6	16	6	443	48.2	8.66	4	2	5	5	4	2	5	5	1671433.75	2149118	3785123.938	2406837.688	5	5	5	5		cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	DNA binding;protein binding;RNA binding	"Pf00013, Pf13014"	10657	ENSG00000121774.17	KHDRBS1	1	PTK6 Regulates Proteins Involved in RNA Processing		0
High	Q8IXB1	DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2	0	18.243	11	8	16	8	793	91	7.18	3	3	5	5	3	3	5	5	1693638.484	2477351.031	5179868.406	5599131.656	5	6	7	7		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;membrane;organelle lumen	catalytic activity;enzyme regulator activity;protein binding	"Pf00085, Pf00226, Pf13098, Pf13728, Pf13848, Pf13905"	54431	ENSG00000077232.17	DNAJC10	2		Protein processing in endoplasmic reticulum	0
High	Q16585	Beta-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCB PE=1 SV=1	0	39.771	39	11	16	11	318	34.8	8.62				11				16	30345.97656		204504.9844	14331052.97	1		2	7	Met-loss+Acetyl [N-Term]	cell organization and biogenesis	cytoplasm;cytoskeleton;membrane		Pf04790	6443	ENSG00000163069.12	SGCB	4		Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Viral myocarditis; Hypertrophic cardiomyopathy (HCM)	0
High	O75531	Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1	0	17.765	57	5	16	5	89	10.1	6.09		4	5	3		5	8	3	166127.7461	10165449.13	11948686.63	3901827.625	2	4	5	4		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytosol;nucleus	DNA binding;protein binding	Pf02961	8815	ENSG00000175334.7	BANF1	11	2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin		0
High	P84098	60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1	0	11.499	23	4	16	4	196	23.5	11.47	2	4	4	3	3	4	6	3	5370480.813	9513321.313	9241091.438	7791698.25	4	4	4	4		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01280	6143	ENSG00000108298.9	RPL19	17	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q96HS1	"Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2"	0	10.805	17	6	16	6	289	32	8.68	2	5	4	4	2	5	5	4	7911715.141	8074938.406	9793690.5	8119154.188	6	6	6	6		cell communication;cell death;metabolic process;regulation of biological process;response to stimulus	membrane;mitochondrion	catalytic activity;enzyme regulator activity;protein binding;signal transducer activity	Pf00300	192111	ENSG00000247077.6	PGAM5	12		TNF signaling pathway	0
High	Q13151	Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1	0	12.667	17	4	15	3	305	30.8	9.29	3	2	3	3	4	3	5	3	2992753.719	4955213.313	3568556.719	3689241.156	3	3	3	3		defense response;metabolic process;regulation of biological process;response to stimulus	nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10949	ENSG00000177733.6	HNRNPA0	5	mRNA Splicing - Major Pathway		0
High	P49207	60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3	0	6.821	28	4	15	4	117	13.3	11.47	4	3	3	2	5	4	4	2	8614250	11753312.75	13633073.25	12712647	4	4	4	4		cell organization and biogenesis;metabolic process;transport	cytosol;mitochondrion;ribosome	protein binding;RNA binding;structural molecule activity	Pf01199	6164	ENSG00000109475.16	RPL34	4	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q96QK8	Small integral membrane protein 14 OS=Homo sapiens OX=9606 GN=SMIM14 PE=1 SV=1	0	18.343	43	2	15	2	99	10.7	5.29			2	2			3	12			11093953.02	42559322.34			3	4	Met-loss [N-Term]; Met-loss+Acetyl [N-Term]		endoplasmic reticulum;membrane	protein binding	Pf11027	201895	ENSG00000163683.11	C4orf34; SMIM14	4			0
High	P62753	40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1	0	19.927	24	6	15	6	249	28.7	10.84	5	3	5	1	5	3	6	1	13457713.38	8815818.125	12107873.5	12833535.75	4	3	3	3		cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01092	6194	ENSG00000137154.12	RPS6	9	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; mTORC1-mediated signalling; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome; Insulin signaling pathway; HIF-1 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Proteoglycans in cancer; mTOR signaling pathway; PI3K-Akt signaling pathway	0
High	Q15084	Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1	0	19.441	23	6	15	6	440	48.1	5.08	3	3	2	6	3	4	2	6	4424638.719	4853318	2939791.156	9672378.563	5	5	4	5		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;endoplasmic reticulum;membrane;organelle lumen	catalytic activity;protein binding	"Pf00085, Pf13098, Pf13848, Pf13899, Pf13905"	10130	ENSG00000143870.12	PDIA6	2	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XBP1(S) activates chaperone genes	Protein processing in endoplasmic reticulum	0
High	Q9Y3U8	60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3	0	8.505	21	3	15	3	105	12.2	11.59	2	3	3	3	2	4	5	4	3755043.469	5274679.094	5863553.875	4270943.688	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;ribosome	RNA binding;structural molecule activity	Pf01158	25873	ENSG00000130255.12	RPL36	19	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q9HCE1	Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2	0	14.475	8	8	15	8	1003	113.6	8.82	5	5	3	2	5	5	3	2	1337481.656	1659366.156	1683453.844	1678932.656	5	6	7	7		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf13086, Pf13087, Pf13245, Pf13401, Pf13604"	4343	ENSG00000155363.18	MOV10	1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence		0
High	Q9ULM3	YEATS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=YEATS2 PE=1 SV=2	0	19.576	8	9	15	9	1422	150.7	8.98		9	6			9	6		45350.69922	3875333.828	2876305.766	154490.9375	1	9	9	1		cell organization and biogenesis;metabolic process;regulation of biological process	nucleus	protein binding	Pf03366	55689	ENSG00000163872.15	YEATS2	3	HATs acetylate histones		0
High	Q92643	GPI-anchor transamidase OS=Homo sapiens OX=9606 GN=PIGK PE=1 SV=2	0	26.822	29	7	15	7	395	45.2	6.16			2	7			3	12	129375.8203	155322.8945	2025290.391	10854373.5	1	2	5	7		metabolic process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf01650	10026	ENSG00000142892.14	PIGK	1	Attachment of GPI anchor to uPAR	Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0
High	O95819	Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2	0	19.858	7	7	15	7	1239	142	7.46	3	4	4	4	3	4	4	4	4221971.781	3734328.406	3331159.422	4264341.742	7	7	6	7		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm	catalytic activity;nucleotide binding;protein binding;signal transducer activity	"Pf00069, Pf00780, Pf07714"	9448	ENSG00000071054.16	MAP4K4	2	Oxidative Stress Induced Senescence	MAPK signaling pathway	0
High	Q9Y4L1	Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1	0	31.702	14	10	15	10	999	111.3	5.22			3	10			4	11	225260.7969	276632.8672	3858703.266	6897489.25	3	3	6	6		regulation of biological process;response to stimulus;transport	endoplasmic reticulum;extracellular;membrane;organelle lumen	nucleotide binding;protein binding	Pf00012	10525	ENSG00000280682.2; ENSG00000149428.18	HYOU1	11; CHR_HG2217_PATCH	Scavenging by Class F Receptors; XBP1(S) activates chaperone genes	Protein processing in endoplasmic reticulum	0
High	P04406	Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3	0	12.779	21	6	15	6	335	36	8.46	2	5	3	5	2	5	3	5	2162109.156	2826952.5	3758912.016	3967064.844	6	6	6	6		cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00044, Pf02800"	2597	ENSG00000111640.14	GAPDH	12	Gluconeogenesis; Glycolysis	HIF-1 signaling pathway; Carbon metabolism; Alzheimer's disease; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways	0
High	P05386	60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1	0	18.011	81	3	14	3	114	11.5	4.32	3	2	3	3	3	3	5	3	4741282.969	3838029.875	5486968.625	3320058.25	3	2	3	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;ribosome	enzyme regulator activity;protein binding;structural molecule activity	Pf00428	6176	ENSG00000137818.11	RPLP1	15	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q00325	"Phosphate carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2"	0	11.887	14	6	14	6	362	40.1	9.38		1	5	6		1	6	7	619204.4453	2337102.688	7023490.813	17453218.25	3	4	5	5		transport	membrane;mitochondrion	protein binding;transporter activity	Pf00153	5250	ENSG00000075415.12	SLC25A3	12			0
High	P50991	T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4	0	18.763	17	7	14	7	539	57.9	7.83	1	2	3	7	1	2	4	7	984363.4609	1260291.656	2557305.813	3950163.531	4	3	4	5		metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol	nucleotide binding;protein binding;RNA binding	Pf00118	10575	ENSG00000115484.14	CCT4	2	BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC		0
High	Q8IYB3	Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2	0	23.688	9	5	14	5	904	102.3	11.84	3	2	4	2	3	3	6	2	3472825.5	2827127.703	4274130.25	2352291.266	3	3	4	3		metabolic process;transport	cytosol;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	Pf01480	10250	ENSG00000133226.16	SRRM1	1	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway	mRNA surveillance pathway; RNA transport	0
High	P12004	Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1	0	13.923	24	6	14	6	261	28.8	4.69	1	1	3	6	1	1	4	8	718187.8047	701200.5938	2432901.781	5863348.031	3	3	5	6		cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;enzyme regulator activity;protein binding	"Pf00705, Pf02747"	5111	ENSG00000132646.10	PCNA	20	Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Activation of E2F1 target genes at G1/S; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Transcription of E2F targets under negative control by DREAM complex; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; SUMOylation of DNA replication proteins; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; E3 ubiquitin ligases ubiquitinate target proteins; Dual incision in TC-NER; Removal of the Flap Intermediate from the C-strand	Hepatitis B; DNA replication; Mismatch repair; Base excision repair; HTLV-I infection; Nucleotide excision repair; Cell cycle	0
High	P62857	40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1	0	10.334	46	3	14	3	69	7.8	10.7	2	3	3	3	3	4	4	3	4642197.75	7352436.375	7553228.25	6880775.25	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytosol;ribosome	protein binding;RNA binding;structural molecule activity	Pf01200	6234	ENSG00000233927.4	RPS28	19	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q08380	Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1	0	8.563	5	3	14	3	585	65.3	5.27	2	2	3	2	4	3	4	3	1268657.281	4055307.875	3029691.156	2809135.5	2	3	3	2		defense response;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	protein binding;receptor activity	"Pf00530, Pf07707"	3959	ENSG00000108679.12	LGALS3BP	17	Platelet degranulation		0
High	O96019	Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1	0	20.269	18	5	14	5	429	47.4	5.6	2	3	3	5	3	3	3	5	5839298.281	6169548.719	9024908.031	8483567.75	4	4	4	5		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	DNA binding;protein binding	Pf00022	86	ENSG00000136518.16	ACTL6A	3	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; UCH proteinases; DNA Damage Recognition in GG-NER; RMTs methylate histone arginines; HATs acetylate histones		0
High	Q8NEZ5	F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1	0	14.818	16	5	14	5	403	44.5	7.03		3	5	3		3	8	3	46937.20313	956299.7813	3163505.438	1681074.234	1	4	4	4		cell communication;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	"Pf00646, Pf10442, Pf12937"	26263	ENSG00000167196.13	FBXO22	15	Antigen processing: Ubiquitination & Proteasome degradation; Neddylation		0
High	P62877	E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1	0	18.905	26	3	14	3	108	12.3	6.96		3	2	3		4	4	6	1290051.344	6894771	7735787.188	8460707.625	2	3	3	3	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00097, Pf12678, Pf12861, Pf13639"	9978	ENSG00000100387.8	RBX1	22	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of RAS by GAPs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Hedgehog 'on' state; Gap-filling DNA repair synthesis and ligation in TC-NER; Degradation of DVL; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Prolactin receptor signaling; Neddylation; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dual incision in TC-NER; Regulation of expression of SLITs and ROBOs	TGF-beta signaling pathway; HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Protein processing in endoplasmic reticulum; Renal cell carcinoma; Nucleotide excision repair; Wnt signaling pathway; Oocyte meiosis; Circadian rhythm; Cell cycle	0
High	P62993	Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1	0	15.789	43	7	14	7	217	25.2	6.32	1	5	4	2	1	6	5	2	504590.4004	4241537.719	5958555.938	2798548.547	4	6	6	7		cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endosome;Golgi;membrane;nucleus	catalytic activity;protein binding;RNA binding	"Pf00017, Pf00018, Pf07653, Pf14604"	2885	ENSG00000177885.13	GRB2	17	"PI3K Cascade; SHC-mediated cascade:FGFR4; Signaling by FGFR4 in disease; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; Signal regulatory protein family interactions; EGFR downregulation; SHC1 events in ERBB4 signaling; NCAM signaling for neurite out-growth; DAP12 signaling; PI-3K cascade:FGFR4; GRB2 events in EGFR signaling; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Constitutive Signaling by EGFRvIII; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin receptor SHC signaling; MET receptor recycling; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; Negative regulation of MET activity; FRS-mediated FGFR2 signaling; CD28 dependent Vav1 pathway; Signalling to RAS; GPVI-mediated activation cascade; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; RET signaling; SHC-mediated cascade:FGFR1; GRB2 events in ERBB2 signaling; PI-3K cascade:FGFR1; PI3K events in ERBB2 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; RAF/MAP kinase cascade; Tie2 Signaling; FCERI mediated Ca+2 mobilization; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; MET activates RAP1 and RAC1; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; MET activates RAS signaling; MET activates PTPN11; Signal attenuation; SHC-mediated cascade:FGFR2; EGFR Transactivation by Gastrin; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; SOS-mediated signalling; Interleukin-20 family signaling; Interleukin-15 signaling; Spry regulation of FGF signaling; Cargo recognition for clathrin-mediated endocytosis; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SHC1 events in EGFR signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; RHO GTPases Activate WASPs and WAVEs; Regulation of KIT signaling; GAB1 signalosome; InlB-mediated entry of Listeria monocytogenes into host cell"	Viral carcinogenesis; T cell receptor signaling pathway; Dorso-ventral axis formation; Osteoclast differentiation; Hepatitis B; Insulin signaling pathway; FoxO signaling pathway; Prolactin signaling pathway; MicroRNAs in cancer; Phospholipase D signaling pathway; Chronic myeloid leukemia; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Natural killer cell mediated cytotoxicity; ErbB signaling pathway; Pathways in cancer; Prostate cancer; Glioma; Gap junction; Renal cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Focal adhesion; Jak-STAT signaling pathway; Proteoglycans in cancer; Choline metabolism in cancer; mTOR signaling pathway; Fc epsilon RI signaling pathway; Hepatitis C; Alcoholism; Ras signaling pathway; Endocrine resistance; GnRH signaling pathway; Chemokine signaling pathway; Signaling pathways regulating pluripotency of stem cells; Estrogen signaling pathway; PI3K-Akt signaling pathway	0
High	Q8N9Q2	Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1	0	10.939	22	4	14	4	155	18.2	9.85	2	2	4	2	4	3	4	3	2788170	2464012.602	4402812.238	3248851.938	2	3	4	2		metabolic process		metal ion binding;protein binding	Pf13917	285672	ENSG00000153006.15	SREK1IP1	5			0
High	Q14697	Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3	0	22.829	11	9	14	9	944	106.8	6.14	1		2	9	1		2	11	432217.5938	532312.5547	1924306.516	9159019.75	4	4	8	9		metabolic process	endoplasmic reticulum;Golgi;membrane;organelle lumen	catalytic activity;RNA binding	"Pf01055, Pf13802"	23193	ENSG00000089597.16	GANAB	11	Calnexin/calreticulin cycle	N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	P55072	Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4	0	35.769	16	10	14	10	806	89.3	5.26	1		9	3	2		9	3	2006567.5	1291959.813	10661161.06	2215087.25	5	3	9	5		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen;proteasome	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401"	7415	ENSG00000165280.15	VCP	9	Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs; Ovarian tumor domain proteases; ABC-family proteins mediated transport; HSF1 activation; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; E3 ubiquitin ligases ubiquitinate target proteins; Neutrophil degranulation; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis	Protein processing in endoplasmic reticulum; Legionellosis	0
High	Q13427	Peptidyl-prolyl cis-trans isomerase G OS=Homo sapiens OX=9606 GN=PPIG PE=1 SV=2	0	11.283	7	5	14	5	754	88.6	10.29	4	2	4	4	4	2	4	4	2035650.188	2115716.984	2646477.813	2502208.75	5	5	5	5		metabolic process	cytosol;nucleus	catalytic activity;protein binding;RNA binding	Pf00160	9360	ENSG00000138398.15	PPIG	2			0
High	Q01081	Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3	0	15.365	19	5	14	5	240	27.9	8.81	4	4	3	3	4	4	3	3	2978912.75	3203344.5	2941009.289	3218875.438	5	5	5	5	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process;transport	nucleus;spliceosomal complex	metal ion binding;protein binding;RNA binding	"Pf00076, Pf00642, Pf13893"	7307; 102724594	ENSG00000160201.11; ENSG00000275895.6	U2AF1; LOC102724594; U2AF1L5	21	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway	Spliceosome; Shigellosis	0
High	O43684	Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1	0	17.854	24	6	14	6	328	37.1	6.84	2	5	4	2	2	5	5	2	1819288.906	2166157.906	4015655.938	2493535.875	3	3	4	3		cell division;cell organization and biogenesis;metabolic process;regulation of biological process	chromosome;cytosol;nucleus	protein binding	"Pf00400, Pf04762"	9184	ENSG00000154473.17	BUB3	10	Inactivation of APC/C via direct inhibition of the APC/C complex; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A	HTLV-I infection; Cell cycle	0
High	P78371	T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4	0	12.406	12	5	14	5	535	57.5	6.46	1	4	5	4	1	4	5	4	674466.3281	1135877.813	1696741	1664674.156	3	4	4	4	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;extracellular;organelle lumen	nucleotide binding;protein binding	Pf00118	10576	ENSG00000166226.12	CCT2	12	BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC		0
High	Q92785	Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2	0	13.864	24	6	14	6	391	44.1	6.33	3	3	2	4	4	4	2	4	2182252.938	2112659.656	1783213.875	4077393.188	4	5	5	5		cell death;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	DNA binding;metal ion binding;protein binding	"Pf00628, Pf14051"	5977	ENSG00000133884.9	DPF2	11			0
High	P0DP25	Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1	0	16.123	31	3	14	3	149	16.8	4.22	1	2	3	2	1	3	5	5	1724322.766	6075239.875	5700858.5	4653357.156	4	4	4	4		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane	catalytic activity;enzyme regulator activity;metal ion binding;protein binding;transporter activity	"Pf00036, Pf08726, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658"	808; 805; 801	ENSG00000160014.16; ENSG00000143933.16; ENSG00000198668.10	CALM3; CALM2; CALM1	19; 2; 14	"Smooth Muscle Contraction; Uptake and function of anthrax toxins; Stimuli-sensing channels; Translocation of GLUT4 to the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Reduction of cytosolic Ca++ levels; CREB phosphorylation through the activation of CaMKII; Ion homeostasis; Ca2+ pathway; Phase 0 - rapid depolarisation; Calcineurin activates NFAT; Platelet degranulation ; eNOS activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; CaMK IV-mediated phosphorylation of CREB; Activation of CaMK IV; RAF/MAP kinase cascade; Inactivation, recovery and regulation of the phototransduction cascade; FCERI mediated Ca+2 mobilization; Cam-PDE 1 activation; Glycogen breakdown (glycogenolysis); Signaling by GPCR; Sodium/Calcium exchangers; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Interleukin-20 family signaling; RHO GTPases activate PAKs; Protein methylation; DARPP-32 events; RHO GTPases activate IQGAPs; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Ras activation uopn Ca2+ infux through NMDA receptor; PKA activation; Ion transport by P-type ATPases; Transcriptional activation of mitochondrial biogenesis; Activation of Ca-permeable Kainate Receptor; CLEC7A (Dectin-1) induces NFAT activation"	Dopaminergic synapse; Phototransduction; Vascular smooth muscle contraction; Insulin signaling pathway; Amphetamine addiction; cGMP-PKG signaling pathway; Renin secretion; Neurotrophin signaling pathway; Rap1 signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; Long-term potentiation; Glioma; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Pertussis; Melanogenesis; Alzheimer's disease; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; Alcoholism; Ras signaling pathway; GnRH signaling pathway; cAMP signaling pathway; Estrogen signaling pathway; Calcium signaling pathway	0
High	Q02543	60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2	0	11.761	20	3	14	3	176	20.7	10.71	2	2	3	2	3	4	4	3	7057282.813	9260005.516	11368324.45	8436437.828	3	3	3	3		cell organization and biogenesis;metabolic process;response to stimulus;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01775	6142	ENSG00000105640.12	RPL18A	19	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q9UK97	F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1	0	22.816	19	8	14	8	447	52.3	6.15		1	8	2		1	11	2	55150.6875	560179.3906	6147467.875	2869704.344	1	2	7	5		cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol	catalytic activity;protein binding	"Pf00646, Pf12937"	26268	ENSG00000112146.16	FBXO9	6	Antigen processing: Ubiquitination & Proteasome degradation; Neddylation		0
High	P46783	40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1	0	13.978	19	4	13	4	165	18.9	10.15	1	3	2	3	2	4	4	3	2278259.813	3960053.672	6689181.375	5701995.156	3	3	4	4		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf03501	6204	ENSG00000124614.13	RPS10	6	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P41252	"Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2"	0	15.647	6	7	13	7	1262	144.4	6.15	3	2	3	5	3	2	3	5	2860626.859	2401415.422	1911368.594	3363002.078	7	5	4	5		cell differentiation;metabolic process;regulation of biological process	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00133, Pf01406, Pf08264, Pf09334"	3376	ENSG00000196305.17	IARS	9	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Aminoacyl-tRNA biosynthesis	0
High	Q9P258	Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2	0	19.787	17	6	13	6	522	56	8.78	2	3	5	3	2	3	5	3	2711817.57	3939773.531	3223846.844	3092087.719	4	4	5	5		cell division;cell organization and biogenesis;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus	protein binding;RNA binding	"Pf00415, Pf13540"	55920	ENSG00000281540.2; ENSG00000179051.13	RCC2	1; CHR_HG2095_PATCH	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins		0
High	Q14978	Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2	0	9.966	7	5	13	5	699	73.6	9.47	3	2	3	3	4	2	4	3	2825838.375	1975009.59	3488721.711	2743344.766	4	4	4	4		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;nucleus	nucleotide binding;protein binding;RNA binding	Pf05022	9221	ENSG00000166197.16	NOLC1	10			0
High	P62861	40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1	0	5.749	19	2	13	2	59	6.6	12.15	2	2	2	2	2	2	5	4	2067249.031	2893982.5	3349027.063	2757739	2	2	2	2		cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport	cytosol;ribosome	RNA binding;structural molecule activity	Pf04758	2197		FAU	11	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"		0
High	P08236	Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2	0	9.412	8	6	13	6	651	74.7	7.02			2	6			3	10	46836.36719	89791.02344	3773940.609	9564060.75	1	1	5	5		metabolic process;transport	extracellular;membrane;organelle lumen;vacuole	catalytic activity;protein binding	"Pf02836, Pf02837, Pf12876"	2990	ENSG00000169919.16	GUSB	7	MPS VII - Sly syndrome; Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation	Lysosome; Glycosaminoglycan degradation; Porphyrin and chlorophyll metabolism; Pentose and glucuronate interconversions; Metabolic pathways; Drug metabolism - other enzymes	0
High	Q96MG8	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PCMTD1 PE=1 SV=2	0	15.117	20	6	13	6	357	40.7	5.66	5	4	2	1	5	5	2	1	2863949.719	3257754.891	3039893	2789897.594	6	6	7	4		metabolic process	cytoplasm;membrane	catalytic activity	"Pf01135, Pf12847, Pf13847"	115294	ENSG00000168300.13	PCMTD1	8			0
High	Q8NCJ5	SPRY domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SPRYD3 PE=1 SV=2	0	14.672	17	6	13	6	442	49.7	6.16		3	4	6		3	4	6	106390.3828	2364536.031	4636442.25	4538387.719	2	5	6	6				protein binding	Pf00622	84926	ENSG00000167778.8	SPRYD3	12			0
High	Q8NC56	LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1	0	19.374	17	7	13	7	503	56.9	9		5	4	2		6	5	2	72395.3125	7704235.156	5152595.5	3623294.332	1	5	5	5		cell differentiation;cell organization and biogenesis;regulation of biological process	chromosome;endoplasmic reticulum;membrane;nucleus	DNA binding;protein binding	"Pf03020, Pf09402"	221496	ENSG00000161904.11	LEMD2	6	Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin		0
High	P35613	Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2	0	20.685	20	6	13	6	385	42.2	5.66			5	2			9	4	302577.1611	769139.8477	8782266.141	7691334.938	4	5	5	5		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	membrane;mitochondrion	protein binding;transporter activity	"Pf00047, Pf07679, Pf13895, Pf13927"	682	ENSG00000172270.18	BSG	19	Integrin cell surface interactions; Proton-coupled monocarboxylate transport; Basigin interactions; Degradation of the extracellular matrix; Pyruvate metabolism		0
High	Q5T4B2	Inactive glycosyltransferase 25 family member 3 OS=Homo sapiens OX=9606 GN=CERCAM PE=1 SV=1	0	41.295	21	10	13	10	595	67.5	6.06				10				13	42909.98047		212276.4922	14271220.13	1		3	8		cellular component movement	endoplasmic reticulum;membrane;organelle lumen		Pf01755	51148	ENSG00000167123.18	CERCAM	9			0
High	Q6NXT6	Transmembrane anterior posterior transformation protein 1 homolog OS=Homo sapiens OX=9606 GN=TAPT1 PE=1 SV=1	0	29.357	18	7	13	7	567	64.2	8.28		7	1			12	1		168585.918	10379800.75	1074538.391	112240.2656	2	6	4	1	Met-loss+Acetyl [N-Term]	cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;membrane	receptor activity;signal transducer activity	Pf05346	202018	ENSG00000169762.16	TAPT1	4			0
High	P62987	Ubiquitin-60S ribosomal protein L40 OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2	0	14.853	48	6	13	1	128	14.7	9.83	1	4	3	3	1	4	4	4										cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome	protein binding;structural molecule activity	"Pf00240, Pf01020, Pf11976, Pf13019, Pf13881, Pf14560"	7311	ENSG00000221983.7	UBA52	19	"NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; Viral mRNA Translation; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Eukaryotic Translation Termination; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; Peptide chain elongation; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; SRP-dependent cotranslational protein targeting to membrane; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Major pathway of rRNA processing in the nucleolus and cytosol; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; GTP hydrolysis and joining of the 60S ribosomal subunit; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell; Formation of a pool of free 40S subunits"	Ribosome	0
High	P09012	U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3	0	8.845	17	4	13	4	282	31.3	9.83	2	2	4	4	2	3	4	4	1515376.344	1920743.141	2747372.563	2571623.875	3	4	4	4	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	6626	ENSG00000077312.8	SNRPA	19	mRNA Splicing - Major Pathway	Spliceosome	0
High	P49327	Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3	0	15.4	4	9	13	9	2511	273.3	6.44	5	1	6	1	5	1	6	1	1999678.125	642015.0625	1155760.313	1337226.484	8	4	6	6	Acetyl [N-Term]	cell differentiation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;Golgi;membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00106, Pf00107, Pf00108, Pf00109, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf13602, Pf14765"	2194	ENSG00000169710.8	FASN	17	ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism; Activation of gene expression by SREBF (SREBP)	Insulin signaling pathway; Fatty acid biosynthesis; AMPK signaling pathway; Metabolic pathways; Fatty acid metabolism	0
High	O43615	Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2	0	19.006	20	8	13	8	452	51.3	8.32	2	1	6	4	2	1	6	4	1125060.5	1665808.898	2846891.078	2598778.25	4	6	7	5		transport	membrane;mitochondrion;organelle lumen	nucleotide binding;protein binding	"Pf04280, Pf07091"	10469	ENSG00000104980.7	TIMM44	19	Mitochondrial protein import; Metabolism of proteins		0
High	P21333	Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4	0	17.915	5	8	13	8	2647	280.6	6.06		6	6	1		6	6	1	587245.8594	2664891.641	2637905.859	1013865.234	5	7	8	6		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus	protein binding;RNA binding;signal transducer activity	"Pf00307, Pf00630"	2316	ENSG00000196924.14	FLNA	X	Platelet degranulation ; RHO GTPases activate PAKs; Cell-extracellular matrix interactions; GP1b-IX-V activation signalling	MAPK signaling pathway; Focal adhesion; Proteoglycans in cancer; Salmonella infection	0
High	Q9P2E9	Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5	0	12.336	16	6	12	6	1410	152.4	8.6	2	4	3	3	2	4	3	3	805173.7188	3476548.813	2556917.641	3835324.313	4	5	5	5												0
High	Q9BU76	Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1	0	10.584	14	3	12	3	263	29.4	10.02	3	1	1	3	5	2	1	4	3400429	1711951.344	2353327.625	5397487.188	3	2	2	2		transport	extracellular;organelle lumen	protein binding;RNA binding	Pf10159	79169	ENSG00000143793.12	C1orf35	1	Neutrophil degranulation		0
High	P10515	"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3"	0	16.371	16	6	12	6	647	69	7.84	6	1	2	1	8	1	2	1	5431338.438	475425.5313	1325292.5	1001623.063	5	2	3	2		metabolic process;regulation of biological process	mitochondrion;organelle lumen	catalytic activity;protein binding	"Pf00198, Pf00364, Pf02817"	1737	ENSG00000150768.15	DLAT	11	Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation	Citrate cycle (TCA cycle); Carbon metabolism; Pyruvate metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways	0
High	Q9NYU2	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3	0	21.512	6	9	12	7	1555	177.1	5.63			2	9			2	10	36682.26563	540098.5156	1765474.391	6447203.938	1	4	7	8		metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;organelle lumen	catalytic activity;protein binding	Pf06427	56886	ENSG00000136731.12	UGGT1	2	ER Quality Control Compartment (ERQC)	Protein processing in endoplasmic reticulum	1
High	P16615	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1	0	25.452	12	10	12	10	1042	114.7	5.34		1	1	10		1	1	10		1776379.641	2297809.047	6264374.625		7	7	8		cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane	catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity	"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246"	488	ENSG00000174437.16	ATP2A2	12	Ion homeostasis; Pre-NOTCH Processing in Golgi; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; cGMP-PKG signaling pathway; Thyroid hormone signaling pathway; Adrenergic signaling in cardiomyocytes; Pancreatic secretion; Alzheimer's disease; Cardiac muscle contraction; cAMP signaling pathway; Calcium signaling pathway; Hypertrophic cardiomyopathy (HCM)	0
High	Q15287	RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1	0	7.65	16	3	12	3	305	34.2	11.84	2	3	2	1	4	4	2	2	5266192.875	5390878.156	5292646	5773907.5	3	3	3	3		metabolic process;regulation of biological process;transport	cytoplasm;cytosol;nucleus	protein binding;RNA binding	"Pf00076, Pf08777, Pf11608, Pf13893, Pf14259"	10921	ENSG00000205937.11	RNPS1	16	mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	mRNA surveillance pathway; RNA transport	0
High	Q8NFD5	AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=2	0	16.871	3	6	12	5	2236	236	6.73	3	1	1	5	4	2	1	5	1181163.734	428199.3438	868349.2188	1527399.344	5	3	4	5		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	DNA binding;protein binding	"Pf01388, Pf03153, Pf09770, Pf12031"	57492	ENSG00000049618.22	ARID1B	6	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		0
High	Q16880	2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Homo sapiens OX=9606 GN=UGT8 PE=2 SV=2	0	25.09	17	10	12	10	541	61.4	9.52			1	10			1	11			893367.1953	14589688.69			6	9		cell organization and biogenesis;metabolic process	membrane	catalytic activity	"Pf00201, Pf04101"	7368	ENSG00000174607.10	UGT8	4	Glycosphingolipid metabolism	Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways	0
High	Q969N2	GPI transamidase component PIG-T OS=Homo sapiens OX=9606 GN=PIGT PE=1 SV=1	0	15.049	10	6	12	6	578	65.7	8.38			4	5			6	6	2978602.594	3629407.625	9408715.031	13181803.06	3	2	6	6		cell death;cell differentiation;metabolic process	cytoplasm;endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf04113	51604	ENSG00000124155.17	PIGT	20	Attachment of GPI anchor to uPAR	Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0
High	P62841	40S ribosomal protein S15 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2	0	9.728	32	2	12	2	145	17	10.39	1	1	2	1	3	3	4	2	539429.3438	692385.6641	1074985.469	969967.6563	2	2	2	2		cell differentiation;cell organization and biogenesis;metabolic process;transport	cytosol;membrane;nucleus;ribosome	DNA binding;protein binding;RNA binding;structural molecule activity	Pf00203	6209	ENSG00000115268.9	RPS15	19	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q8TCT9	Minor histocompatibility antigen H13 OS=Homo sapiens OX=9606 GN=HM13 PE=1 SV=1	0	19.396	12	3	12	3	377	41.5	6.43			3	2			10	2	336681.5625	217658.2109	20631624.34	3261930.188	1	2	4	3		cell organization and biogenesis;metabolic process	cell surface;endoplasmic reticulum;membrane	catalytic activity;protein binding	"Pf04258, Pf06550"	81502	ENSG00000101294.16	HM13	20			0
High	P25205	DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3	0	16.79	13	8	12	8	808	90.9	5.77			5	7			5	7	860994.0156	916555.3516	3959555.656	4000784.469	5	6	8	8	Met-loss+Acetyl [N-Term]	metabolic process	cytoplasm;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00493, Pf01078, Pf07728, Pf14551"	4172	ENSG00000112118.18	MCM3	6	M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins	DNA replication; Cell cycle	0
High	Q93074	Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4	0	15.074	5	6	12	6	2177	242.9	7.05	1	4	3	4	1	4	3	4	3340857.641	3547452.094	3383513.531	3564398.438	6	6	6	6	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	catalytic activity;DNA binding;protein binding;receptor activity	"Pf09497, Pf12144, Pf12145"	9968	ENSG00000184634.15	MED12	X	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
High	Q8IV63	Inactive serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2	0	13.074	14	6	12	6	474	52.8	9.04		5	4	2		6	4	2		3659916.203	3276571.109	1557947.844		6	6	3		metabolic process;regulation of biological process	cytoplasm;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf10571, Pf12773, Pf13240, Pf13248"	51231	ENSG00000105053.10	VRK3	19	ERKs are inactivated; Activated TLR4 signalling		0
Medium	Q96Q89	Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3	0.019	1.555	0	1	12	1	1820	210.5	5.67		1	1	1		5	5	2	577810496	549891520	453714432	596586624	1	1	1	1		cell division;cell organization and biogenesis;cellular component movement;regulation of biological process	cytoplasm;cytoskeleton;cytosol;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding	"Pf00225, Pf01576, Pf02463, Pf03961, Pf07851, Pf09726"	9585	ENSG00000138182.14	KIF20B	10	COPI-dependent Golgi-to-ER retrograde traffic; Kinesins		0
High	P46779	60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3	0	11.919	30	4	12	4	137	15.7	12.02	2	3	3	3	2	3	4	3	6522044.5	8018759.25	7554298.5	7348304.375	4	4	4	4	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01778	6158	ENSG00000108107.14	RPL28	19	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q9Y5M8	Signal recognition particle receptor subunit beta OS=Homo sapiens OX=9606 GN=SRPRB PE=1 SV=3	0	22.614	31	7	11	7	271	29.7	9.04			2	7			2	9	279874.2109	548604.4609	2985476.578	8014726.594	3	4	7	7		regulation of biological process;response to stimulus	cytoplasm;endoplasmic reticulum;membrane	nucleotide binding	"Pf00009, Pf00025, Pf01926, Pf02421, Pf09439"	58477	ENSG00000144867.11	SRPRB	3	XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane	Protein export	0
High	P04844	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3	0	34.632	23	9	11	9	631	69.2	5.69			1	9			1	10		454506.2188	1339768.922	10455622.59		2	4	7		metabolic process;response to stimulus	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf05817	6185	ENSG00000118705.16	RPN2	20	Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane	N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	Q9BSG0	Protease-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRADC1 PE=1 SV=1	0	13.981	28	5	11	5	188	21	5.47			3	5			3	8			6255436.25	21872114			4	4			extracellular	protein binding	Pf02225	84279	ENSG00000135617.3	PRADC1	2			0
High	P53621	Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2	0	14.34	6	7	11	7	1224	138.3	7.66	1	2	1	7	1	2	1	7	399732.4453	713703.75	1293646.367	2070530.484	3	4	5	5		regulation of biological process;transport	cytoplasm;cytosol;extracellular;Golgi;membrane	protein binding;structural molecule activity	"Pf00400, Pf04053, Pf06957"	1314	ENSG00000122218.14	COPA	1	COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport		0
High	Q9P2E5	Chondroitin sulfate glucuronyltransferase OS=Homo sapiens OX=9606 GN=CHPF2 PE=2 SV=2	0	20.457	13	9	11	9	772	85.9	7.83				9				11	159174.0781	272575.7188	782586.2344	8220891.75	1	1	3	8		metabolic process	Golgi;membrane	catalytic activity	"Pf02434, Pf05679"	54480	ENSG00000033100.16	CHPF2	7	Chondroitin sulfate biosynthesis	Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0
High	Q96H79	Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2	0	14.693	20	4	11	4	300	32.9	8.13	4	4	2	1	4	4	2	1	1332448.281	1769620.781	1030275.094	1195650	4	4	4	3			cytosol	metal ion binding		92092	ENSG00000146858.7	ZC3HAV1L	7			0
High	Q9HCM4	Band 4.1-like protein 5 OS=Homo sapiens OX=9606 GN=EPB41L5 PE=1 SV=3	0	17.581	12	6	11	6	733	81.8	6.58	3	1	2	4	3	1	2	5	4358889.969	2749887.688	2846693.063	4950399.5	5	5	5	5		cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;structural molecule activity	"Pf00373, Pf08736, Pf09379, Pf09380"	57669	ENSG00000115109.13	EPB41L5	2	Neurexins and neuroligins		0
High	P35268	60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2	0	15.723	39	3	11	3	128	14.8	9.19	1	1	2	3	2	2	3	4	3838798.375	4018084.094	5180033.438	6550811.625	3	2	3	3		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf01776	6146	ENSG00000116251.9	RPL22	1	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q14103	Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1	0	10.857	13	4	11	3	355	38.4	7.81	1	3	3	2	1	5	3	2	1624105.734	3527273.563	3184055.563	2524676.75	3	2	2	2		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	3184	ENSG00000138668.18	HNRNPD	4	mRNA Splicing - Major Pathway		0
High	P14923	Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3	0	15.729	11	7	11	6	745	81.7	6.14	2	4	3	2	2	4	3	2	1655106.688	2218776.828	1975327.766	2281570.406	6	7	7	7		cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	protein binding;signal transducer activity;structural molecule activity	Pf00514	3728	ENSG00000173801.16	JUP	17	Adherens junctions interactions; Neutrophil degranulation; Formation of the cornified envelope; VEGFR2 mediated vascular permeability	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Acute myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer	1
High	P04637	Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4	0	10.232	13	6	11	6	393	43.6	6.79	4	1	3	2	4	1	4	2	2823827.906	3407042.188	3171369.625	2664242.438	6	6	6	6		cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus;organelle lumen	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00870, Pf07710, Pf08563"	7157	ENSG00000141510.16	TP53	17	TP53 Regulates Transcription of Caspase Activators and Caspases; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Ovarian tumor domain proteases; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Factors involved in megakaryocyte development and platelet production; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Regulation of TP53 Expression; Regulation of TP53 Activity through Phosphorylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Pre-NOTCH Transcription and Translation; The role of GTSE1 in G2/M progression after G2 checkpoint; G2/M DNA damage checkpoint; Ub-specific processing proteases; PI5P Regulates TP53 Acetylation; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Methylation; Activation of NOXA and translocation to mitochondria; Association of TriC/CCT with target proteins during biosynthesis; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Interleukin-4 and 13 signaling; Formation of Senescence-Associated Heterochromatin Foci (SAHF); TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Oxidative Stress Induced Senescence; RUNX3 regulates CDKN1A transcription	Viral carcinogenesis; Hepatitis B; Central carbon metabolism in cancer; Pancreatic cancer; MicroRNAs in cancer; Chronic myeloid leukemia; Epstein-Barr virus infection; Neurotrophin signaling pathway; Huntington's disease; Non-small cell lung cancer; MAPK signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; Glioma; Melanoma; HTLV-I infection; Apoptosis; Wnt signaling pathway; Proteoglycans in cancer; Transcriptional misregulation in cancer; p53 signaling pathway; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Herpes simplex infection; Amyotrophic lateral sclerosis (ALS); Thyroid cancer; Hepatitis C; Cell cycle; Endocrine resistance; Basal cell carcinoma; Longevity regulating pathway; PI3K-Akt signaling pathway; Platinum drug resistance	0
High	Q9UK99	F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3	0	21.77	19	6	11	6	471	54.5	5		1	5	5		1	5	5	77359.52734	2997028.625	4406601.453	4613020.531	2	5	6	6		metabolic process;regulation of biological process	cytosol;nucleus	catalytic activity;protein binding	"Pf00646, Pf04379, Pf06881, Pf09346, Pf12937"	26273	ENSG00000110429.13	FBXO3	11			0
High	Q14683	Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2	0	19.913	8	8	11	8	1233	143.1	7.64	1	1	1	7	1	1	1	8	2972110.633	3753690.809	4126341.672	7015252.281	4	5	5	7		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytosol;nucleus	nucleotide binding;protein binding;RNA binding	"Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558"	8243	ENSG00000072501.17	SMC1A	X	Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins	Oocyte meiosis; Cell cycle	0
High	B5ME19	Eukaryotic translation initiation factor 3 subunit C-like protein OS=Homo sapiens OX=9606 GN=EIF3CL PE=1 SV=1	0	19.196	9	8	11	8	914	105.4	5.64		6	2	2		7	2	2	758223.8203	3225380.594	2806605.734	1307909.555	5	7	8	6		metabolic process	cytoplasm	protein binding;RNA binding	"Pf01399, Pf05470"	728689	ENSG00000205609.12	EIF3CL	16		RNA transport	0
High	O14654	Insulin receptor substrate 4 OS=Homo sapiens OX=9606 GN=IRS4 PE=1 SV=1	0	15.158	6	7	11	7	1257	133.7	8.44	1	1	2	6	1	1	2	7	1352956.129	1509486.996	3380592.797	10352018.23	4	4	5	6		regulation of biological process;response to stimulus	cytosol;membrane	protein binding;signal transducer activity	"Pf00169, Pf02174"	8471	ENSG00000133124.11	IRS4	X	IRS-related events triggered by IGF1R	Longevity regulating pathway - multiple species; Insulin signaling pathway; FoxO signaling pathway; cGMP-PKG signaling pathway; Type II diabetes mellitus; AMPK signaling pathway; Regulation of lipolysis in adipocytes; Adipocytokine signaling pathway; Longevity regulating pathway	0
High	Q2M2I8	AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3	0	17.976	10	7	11	7	961	103.8	6.6		4	4	3		4	4	3		3592679.625	3804311.844	5558422.031		6	5	5		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf07714"	22848	ENSG00000115977.18	AAK1	2	Cargo recognition for clathrin-mediated endocytosis		0
High	Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1	0	8.579	7	4	11	4	628	68.7	5.69		4	4	2		5	4	2	249823.1172	1738811.594	1724425.328	1346839.063	2	4	4	3		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;metal ion binding;protein binding	Pf00622	9070	ENSG00000129691.15	ASH2L	8	Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex		0
High	Q04837	"Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1"	0	17.746	39	5	11	5	148	17.2	9.6		5	3	1		7	3	1	476216.5859	9936840.75	6775865.063	4356158.875	3	4	4	4		cell organization and biogenesis;metabolic process;regulation of biological process	mitochondrion;nucleus;organelle lumen	DNA binding;protein binding;RNA binding	Pf00436	6742	ENSG00000106028.10	SSBP1	7	Transcriptional activation of mitochondrial biogenesis	Homologous recombination; DNA replication; Mismatch repair	0
High	Q8N0V3	"Putative ribosome-binding factor A, mitochondrial OS=Homo sapiens OX=9606 GN=RBFA PE=1 SV=3"	0	21.027	23	5	11	5	343	38.3	7.85	3	2	2	3	4	2	2	3	2067988.641	956892.3477	871986.6094	1707186.359	4	4	3	4		metabolic process	mitochondrion	catalytic activity;protein binding	"Pf02033, Pf02637"	79863	ENSG00000101546.12	RBFA	18			0
High	P32969	60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1	0	8.481	24	4	11	4	192	21.9	9.95	1	3	3	2	1	3	5	2	1567356.781	2706474.75	3237994.938	2956626	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;nucleus;ribosome	protein binding;RNA binding;structural molecule activity	Pf00347	6133	ENSG00000163682.15	RPL9	4	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	O15047	Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3	0	14.235	5	8	11	8	1707	185.9	5.14		6	5			6	5		33508420	41208176.73	33306807.33	36138540.47	1	7	8	6		cell organization and biogenesis;metabolic process;regulation of biological process	chromosome;nucleus	catalytic activity;protein binding;RNA binding	"Pf00076, Pf00856, Pf11764, Pf14259"	9739	ENSG00000099381.17	SETD1A	16	PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Lysine degradation	0
High	Q9C005	Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1	0	6.559	27	3	11	3	99	11.2	4.88	1	2	3	3	1	2	4	4	594746.2188	2292029.125	3724926.375	2564403.438	3	3	3	3		cell organization and biogenesis;metabolic process;regulation of biological process;transport	Golgi;nucleus	catalytic activity;protein binding	Pf05186	84661	ENSG00000162961.13	DPY30	2	PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function		0
High	P52292	Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1	0	8.223	6	3	10	3	529	57.8	5.4	2	3	3	2	2	3	3	2	962483.0625	800384.2188	1740435	1780789.25	3	3	3	3		metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding;transporter activity	"Pf00514, Pf01749, Pf13513, Pf13646"	3838	ENSG00000182481.8	KPNA2	17	ISG15 antiviral mechanism;  NS1 Mediated Effects on Host Pathways; Sensing of DNA Double Strand Breaks	Influenza A	0
High	Q9UHI6	Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2	0	13.584	10	6	10	6	824	92.2	6.95	6		2		8		2		1032183.531	304453.5938	376800.1875	187111.6094	2	2	2	1		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00270, Pf00271"	11218	ENSG00000064703.11	DDX20	1	snRNP Assembly	RNA transport	0
High	Q92530	Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2	0	12.652	14	3	10	3	271	29.8	5.74		2	2	3		3	3	4	20700.70117	2451058.922	2676858.156	3544630.438	1	3	3	3	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;proteasome	enzyme regulator activity;protein binding	"Pf08577, Pf11566"	9491	ENSG00000125818.17	PSMF1	20	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	O95232	Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2	0	11.207	9	3	10	3	432	51.4	9.79	2	2	3	3	2	2	3	3	1469317.125	1781640.281	2293022.688	2008423.063	3	3	3	3		cell organization and biogenesis;metabolic process	nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	Pf03194	51747	ENSG00000108848.15	LUC7L3	17			0
High	O75718	Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1	0	15.148	16	7	10	7	401	46.5	5.73				7				10		116430.7344	75276.42969	12349579.5		2	1	7		metabolic process;regulation of biological process	endoplasmic reticulum;extracellular;organelle lumen	protein binding		10491	ENSG00000170275.14	CRTAP	3	Collagen biosynthesis and modifying enzymes		0
High	Q93063	Exostosin-2 OS=Homo sapiens OX=9606 GN=EXT2 PE=1 SV=1	0	19.971	14	8	10	8	718	82.2	6.55				8				10	3858171.742	10959563.09	10187161.57	17276001.81	4	4	5	8		cell differentiation;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding;protein binding	"Pf03016, Pf09258"	2132	ENSG00000151348.13	EXT2	11	HS-GAG biosynthesis; Defective EXT2 causes exostoses 2	Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways	0
High	P29692	Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5	0	11.127	12	3	10	3	281	31.1	5.01	2	2	3	3	2	2	3	3	838321.8438	802741.125	1398722.563	1162135.094	2	2	3	3	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;nucleus	DNA binding;protein binding;RNA binding;signal transducer activity	"Pf00736, Pf10587"	1936	ENSG00000104529.17; ENSG00000273594.4	EEF1D	8; CHR_HSCHR8_3_CTG7	Eukaryotic Translation Elongation	Herpes simplex infection	0
High	P23284	Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2	0	7.356	16	3	10	3	216	23.7	9.41		3	2	3		3	2	5	977029.0391	1495707.844	1193286.766	2667529.688	3	3	3	3		metabolic process;regulation of biological process	endoplasmic reticulum;membrane;nucleus;organelle lumen	catalytic activity;protein binding;RNA binding	Pf00160	5479	ENSG00000166794.4	PPIB	15	Collagen biosynthesis and modifying enzymes		0
High	P46782	40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4	0	10.932	17	3	10	3	204	22.9	9.72	2	3	3	2	2	3	3	2	3552203.625	4512198.469	6708839.406	5651831.375	3	3	3	3		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00177	6193	ENSG00000083845.8	RPS5	19	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2	0	9.16	17	5	10	5	385	44.1	6.23	4	2	1	3	4	2	1	3	4971368.781	3885611.57	4160858.938	8125257.156	5	4	4	5		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	DNA binding;protein binding	Pf04855	6598	ENSG00000099956.18; ENSG00000275837.3	SMARCB1	22; CHR_HSCHR22_1_CTG7	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines		0
High	P62899	60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1	0	10.679	38	5	10	5	125	14.5	10.54	3	1	4	2	3	1	4	2	7038203.875	10446499.69	11323878.75	9232769.625	5	5	5	5		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01198	6160	ENSG00000071082.10	RPL31	2	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P26196	Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2	0	12.134	14	4	10	4	483	54.4	8.66	3	2		3	3	3		4	1720501	1203641.125	1422818.188	1589445.094	4	2	3	3		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf14617"	1656	ENSG00000110367.11	DDX6	11	mRNA decay by 5' to 3' exoribonuclease	RNA degradation	0
High	Q9H4P4	E3 ubiquitin-protein ligase NRDP1 OS=Homo sapiens OX=9606 GN=RNF41 PE=1 SV=2	0	14.449	24	4	9	4	317	35.9	6.14	3	2	1	1	4	3	1	1	2643376.875	1682815.078	1298768.047	1893630	3	3	3	2		cell death;metabolic process;regulation of biological process;response to stimulus	cytosol	catalytic activity;metal ion binding;protein binding	"Pf00097, Pf08941, Pf12678, Pf13639, Pf13923, Pf14835, Pf15227"	10193	ENSG00000181852.17	RNF41	12	Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB2:ERBB3 signaling	Endocytosis	0
High	P49756	RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3	0	11.687	11	6	9	6	843	100.1	6.32	1		3	5	1		3	5	916069.7031	990162.9688	1776484.844	1289991.313	4	4	4	4		metabolic process;regulation of biological process	cytoplasm;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf01480, Pf14259"	58517	ENSG00000119707.13	RBM25	14		Spliceosome	0
High	P63167	"Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1"	0	17.182	37	2	9	2	89	10.4	7.4	1	1	2	2	1	1	4	3	2043812.047	1243639.813	2032158.563	2249492.594	3	3	2	3		cell communication;cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus	catalytic activity;motor activity;protein binding	Pf01221	8655	ENSG00000088986.10	DYNLL1	12	COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Activation of BIM and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; MHC class II antigen presentation; Macroautophagy	Vasopressin-regulated water reabsorption	0
High	Q9P0U4	CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2	0	7.245	6	3	9	3	656	75.7	8.24		2	2	2		3	3	3	60575.33984	1469925.156	953904.3125	1232107.875	1	2	1	2		cell organization and biogenesis;metabolic process;regulation of biological process	cytosol;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding	"Pf00628, Pf02008, Pf12269"	30827	ENSG00000154832.14	CXXC1	18	XBP1(S) activates chaperone genes		0
High	O43809	Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1	0	5.842	15	3	9	3	227	26.2	8.82	3	2	2		5	2	2		1514801.531	890049.6563	824480.4844	810126.8438	3	2	2	2		cell organization and biogenesis;metabolic process	nucleus	catalytic activity;protein binding;RNA binding	Pf13869	11051	ENSG00000167005.13	NUDT21	16	Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway	mRNA surveillance pathway	0
High	P68400	Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1	0	7.965	10	3	9	3	391	45.1	7.74		3	3	3		3	3	3	347865.3906	767145.0938	985095.7188	817252.6563	2	3	3	3		cell communication;cell death;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;membrane;nucleus	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00069, Pf01636, Pf07714"	1457	ENSG00000101266.17	CSNK2A1	20	WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation	Tight junction; Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Wnt signaling pathway; Adherens junction; Measles; Herpes simplex infection	0
High	O75400	Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2	0	7.581	3	4	9	4	957	108.7	7.56	1	2	3	3	1	2	3	3	1339300.234	1548203.633	2443865.953	1727138.375	4	4	4	3		cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process	cytosol;membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00397, Pf01846"	55660		PRPF40A	2	mRNA Splicing - Major Pathway	Spliceosome	0
High	P34897	"Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3"	0	11.771	10	5	9	4	504	56	8.53	2	1	3	2	3	1	3	2	755772.4453	1028458.703	1601688.875	1146773.688	4	4	4	3		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;protein binding	Pf00464	6472	ENSG00000182199.10	SHMT2	12	Metabolism of folate and pterines	"Carbon metabolism; Glycine, serine and threonine metabolism; Antifolate resistance; Biosynthesis of amino acids; One carbon pool by folate; Metabolic pathways; Glyoxylate and dicarboxylate metabolism"	0
High	P18887	DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=2	0	14.629	11	6	9	6	633	69.4	6.39		6	1	1		7	1	1		3723716.469	1334848.875	834917.7188		4	4	3		metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;protein binding	"Pf00533, Pf01834, Pf12738"	7515		XRCC1	19	Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER	Base excision repair	0
High	Q14008	Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3	0	20.18	5	9	9	9	2032	225.4	7.8		9				9			1136273.602	5601739.594	3223628.297	868462.1797	3	7	5	4		cell division;cell organization and biogenesis;regulation of biological process;transport	chromosome;cytoplasm;cytoskeleton;cytosol;membrane	protein binding	Pf12348	9793	ENSG00000175216.14	CKAP5	11	Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins		0
High	O75340	Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1	0	7.829	13	3	9	3	191	21.9	5.4	1	1	3	2	1	1	4	3	526506.5859	1141464.5	2608359.563	2800326.688	3	3	3	3		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00036, Pf13405, Pf13499, Pf13833"	10016	ENSG00000249915.7	PDCD6	5			0
High	Q9HA77	"Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1"	0	10.766	8	4	9	4	564	62.2	8.34		3	4	2		3	4	2		613971.4766	1258287.844	1021062.813		4	4	4		metabolic process	cytoplasm;mitochondrion;organelle lumen	catalytic activity;metal ion binding;nucleotide binding	"Pf00133, Pf01406, Pf01921, Pf09334"	79587	ENSG00000134905.16	CARS2	13	Mitochondrial tRNA aminoacylation	Aminoacyl-tRNA biosynthesis	0
High	Q13625	Apoptosis-stimulating of p53 protein 2 OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=2	0	15.763	7	5	9	5	1128	125.5	6.07		3	2	3		3	2	4	108025.1504	1329944.656	2376149.563	3049607.719	2	4	4	4		cell death;metabolic process;regulation of biological process;response to stimulus	cytoplasm;mitochondrion;nucleus	protein binding	"Pf00018, Pf00023, Pf04111, Pf04156, Pf06785, Pf07653, Pf12252, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604, Pf15548"	7159		TP53BP2	1	Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation of PUMA and translocation to mitochondria	Hippo signaling pathway	0
High	Q9UHX1	Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1	0	13.064	17	5	9	5	559	59.8	5.29	1	1	3	3	1	1	4	3	1558292.344	2116549.094	3349539.656	1983528.531	4	5	5	4		cell death;cellular homeostasis;metabolic process;regulation of biological process	nucleus	catalytic activity;DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	22827	ENSG00000274081.4; ENSG00000179950.13	PUF60	8; CHR_HSCHR8_3_CTG7	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q9NP64	Nucleolar protein of 40 kDa OS=Homo sapiens OX=9606 GN=ZCCHC17 PE=1 SV=1	0	10.626	20	4	9	4	241	27.6	9.7	2	1	4	2	2	1	4	2	1756986.641	1716134.656	2237116.344	2294387.891	4	4	4	4			nucleus	metal ion binding;protein binding;RNA binding	Pf00575	51538	ENSG00000121766.15	ZCCHC17	1			0
High	Q9H307	Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5	0	9.146	6	5	9	5	717	81.6	7.14	1	2	3	2	1	3	3	2	2839576.906	3196148.969	2353314.313	2980122.063	5	5	4	4												0
High	Q13162	Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1	0	8.964	15	4	9	2	271	30.5	6.29		2	2	4		2	2	5	272159.5313	521306.1875	630383.2031	1384065.313	2	2	2	2		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus;organelle lumen	antioxidant activity;catalytic activity;protein binding	"Pf00578, Pf08534, Pf10417"	10549	ENSG00000123131.12	PRDX4	X	Neutrophil degranulation		0
High	O75694	Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1	0	11.045	6	6	9	6	1391	155.1	6.16	3	1	2	3	3	1	2	3	1392083.891	1029579.164	1088751.5	1999331.313	5	5	5	6		cell organization and biogenesis;metabolic process;regulation of biological process;transport	membrane;nucleus	protein binding;structural molecule activity;transporter activity	"Pf03177, Pf08801"	9631	ENSG00000113569.15	NUP155	5	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	P62937	Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2	0	10.209	29	4	9	4	165	18	7.81	1	2	3	3	1	2	3	3	1718290.219	3003923.031	2527996.344	2924956.531	3	4	4	4		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;protein binding;RNA binding	Pf00160	5478	ENSG00000196262.13	PPIA	7	Budding and maturation of HIV virion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Minus-strand DNA synthesis; Binding and entry of HIV virion; Basigin interactions; APOBEC3G mediated resistance to HIV-1 infection; Uncoating of the HIV Virion; Calcineurin activates NFAT; Platelet degranulation ; Plus-strand DNA synthesis; Integration of provirus; Neutrophil degranulation; Assembly Of The HIV Virion; Interleukin-12 family signaling		0
High	Q9NRB3	Carbohydrate sulfotransferase 12 OS=Homo sapiens OX=9606 GN=CHST12 PE=2 SV=2	0	27.175	24	6	9	6	414	48.4	9.32			4	5			4	5			1590860.219	1927044.094			4	4		metabolic process	Golgi;membrane	catalytic activity;nucleotide binding	Pf03567	55501	ENSG00000136213.9	CHST12	7	Chondroitin sulfate biosynthesis	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0
High	Q6P2Q9	Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2	0	10.445	2	4	9	4	2335	273.4	8.84	1	3	3	2	1	3	3	2	541187.5078	755776.3906	782419.3594	866750.2969	3	3	3	3		cell organization and biogenesis;metabolic process;response to stimulus	membrane;nucleus;spliceosomal complex	catalytic activity;protein binding;RNA binding	"Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134"	10594	ENSG00000174231.16; ENSG00000274442.2	PRPF8	17; CHR_HSCHR17_1_CTG2	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	Q9Y3I1	F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1	0	15.448	12	5	9	5	522	58.5	6.55		2	4	3		2	4	3		3673842.438	2577569.063	4684962.938		5	4	5		metabolic process;regulation of biological process;transport	cytoplasm;cytosol;mitochondrion;nucleus	catalytic activity;protein binding	"Pf11566, Pf12937"	25793	ENSG00000100225.17	FBXO7	22	Antigen processing: Ubiquitination & Proteasome degradation; Neddylation		0
High	Q8N1N4	"Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2"	0	4.399	4	2	9	1	520	56.8	6.02	1	2	2	1	2	3	2	2			125447.3125	177729.9375			1	1		cell death	cytosol	structural molecule activity	"Pf00038, Pf12128, Pf13166"	196374	ENSG00000170423.12	KRT78	12	Formation of the cornified envelope		0
High	Q96C36	Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1	0	9.329	13	4	8	3	320	33.6	7.77		2	1	4		3	1	4	429870.5703	1009875.078	318600.6563	2858329.719	3	3	1	4		metabolic process;response to stimulus	cytoplasm;mitochondrion;organelle lumen	catalytic activity;nucleotide binding	"Pf01210, Pf03807, Pf14748"	29920	ENSG00000143811.18	PYCR2	1	Amino acid synthesis and interconversion (transamination)	Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism	1
High	Q8N1F7	Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2	0	12.634	6	5	8	5	819	93.4	5.72			2	5			2	6	1508742.414	1787140.594	2193835.594	3755621.203	2	3	3	4		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	membrane;nucleus	protein binding;structural molecule activity	Pf04097	9688	ENSG00000102900.12	NUP93	16	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	P22087	rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2	0	12.827	10	2	8	2	321	33.8	10.18	1	1	2	2	1	1	3	3	526835.4375	529289.2188	1273058.578	1203100.297	2	2	3	2		cell differentiation;cell organization and biogenesis;metabolic process	chromosome;membrane;nucleus	catalytic activity;protein binding;RNA binding	"Pf01135, Pf01269, Pf13847"	2091	ENSG00000280548.3; ENSG00000105202.8	FBL	19; CHR_HG2021_PATCH	Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol	Ribosome biogenesis in eukaryotes	0
High	P24666	Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3	0	3.445	6	1	8	1	158	18	6.74	1	1	1	1	2	2	2	2	420040.4063	857572.9375	1123970.25	1849431.75	1	1	1	1		metabolic process	cytoplasm;cytosol;membrane	catalytic activity;protein binding	Pf01451	52	ENSG00000143727.15	ACP1	2		Thiamine metabolism; Adherens junction; Metabolic pathways	0
High	P26599	Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1	0	12.684	11	5	8	5	531	57.2	9.17	2	1	3	2	2	1	3	2	3103933.281	3029422.203	2889511.969	3071044.344	5	5	4	4		metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	5725	ENSG00000011304.19	PTBP1	19	mRNA Splicing - Major Pathway; FGFR2 alternative splicing		0
High	Q86YZ3	Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2	0	7.886	1	2	8	2	2850	282.2	10.04	2	2	1	1	3	3	1	1	2485818.891	2260225.5	1420959	1562158.875	2	2	1	1		cell organization and biogenesis;development;transport	cytoplasm;cytoskeleton;extracellular;nucleus;organelle lumen	metal ion binding		388697	ENSG00000197915.5	HRNR	1	Neutrophil degranulation		0
High	Q69YQ0	Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=2	0	14.556	5	4	8	4	1117	124.5	5.72	3	4	1		3	4	1		815759.2031	1862103.469	588171.4063		4	4	3			cell division;metabolic process	cytoplasm;cytoskeleton;cytosol	protein binding;structural molecule activity	"Pf00038, Pf00307, Pf01920, Pf02463, Pf03251, Pf04111, Pf04156, Pf05667, Pf05701, Pf08317, Pf11971, Pf12128, Pf13166"	23384		SPECC1L	22			0
High	O15226	NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2	0	12.439	10	6	8	6	690	77.6	8.79	3	2	3		3	2	3		1560488.781	1262595.328	2019895.063	1567473.531	5	5	4	4		metabolic process;regulation of biological process	nucleus	DNA binding;protein binding;RNA binding	"Pf00035, Pf01424, Pf01585, Pf12656"	55922	ENSG00000186416.13	NKRF	X			0
High	Q9Y597	BTB/POZ domain-containing protein KCTD3 OS=Homo sapiens OX=9606 GN=KCTD3 PE=1 SV=2	0	12.237	12	7	8	7	815	88.9	7.03	7				8				3320528.203	4494005.523	5213387.031	6364176	5	2	2	1		cell organization and biogenesis	membrane	protein binding	Pf02214	51133	ENSG00000136636.12	KCTD3	1			0
High	P39656	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4	0	24.442	26	6	8	6	456	50.8	6.55			1	6			1	7	48230.5	387817.875	920258.8438	7538864.313	1	2	2	4		metabolic process;response to stimulus;transport	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf03345	1650	ENSG00000244038.9	DDOST	1	Advanced glycosylation endproduct receptor signaling; Asparagine N-linked glycosylation; Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane	N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	P62854	40S ribosomal protein S26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3	0	4.25	21	2	8	2	115	13	11	1	2	2	1	2	3	2	1	3223430.469	5186056.313	6005649.563	4659151.625	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01283	6231; 101929876; 728937	ENSG00000197728.9	RPS26; LOC101929876; RPS26P25	12; 20; 4	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P47914	60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2	0	4.974	9	1	8	1	159	17.7	11.66	1	1	1	1	2	2	2	2	3038314.25	6057936.5	7838293	5565122.5	1	1	1	1		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf01779	6159	ENSG00000162244.10	RPL29	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	P50990	T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4	0	10.057	9	4	8	4	548	59.6	5.6	1	2	3	2	1	2	3	2	468564.5781	746298.7188	997800.25	1021538.859	3	3	3	3		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;organelle lumen	catalytic activity;nucleotide binding;protein binding	Pf00118	10694	ENSG00000156261.12	CCT8	21	BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC		0
High	O00264	Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3	0	10.048	21	4	8	4	195	21.7	4.7		1	3	4		1	3	4	79418.28125	614383	1970389.344	1838884.922	1	4	4	4		transport	endoplasmic reticulum;membrane	protein binding	Pf00173	10857	ENSG00000101856.9	PGRMC1	X	Neutrophil degranulation		0
High	Q13573	SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1	0	5.865	7	4	8	4	536	61.5	9.52	1	2	2	3	1	2	2	3	901273.3281	1181655.125	889715.2813	690748.6094	3	4	4	3		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus;spliceosomal complex	catalytic activity;protein binding;RNA binding	Pf02731	22938	ENSG00000100603.13	SNW1	14	NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; mRNA Splicing - Major Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation	Viral carcinogenesis; Epstein-Barr virus infection; Spliceosome; Notch signaling pathway	0
High	Q8IY17	Patatin-like phospholipase domain-containing protein 6 OS=Homo sapiens OX=9606 GN=PNPLA6 PE=1 SV=3	0	17.751	6	6	8	6	1375	150.9	7.74			6	1			7	1		1536499.797	1725752.234	1382597.734		5	4	4												0
High	Q9BQG0	Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2	0	12.609	5	7	8	7	1328	148.8	9.28	1	1	4	2	1	1	4	2	1010389.738	1093229.465	2064599.07	1462286.383	6	4	6	5		cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;membrane;nucleus	catalytic activity;DNA binding;protein binding;RNA binding	"Pf04931, Pf05793, Pf11593, Pf12815"	10514	ENSG00000132382.14	MYBBP1A	17	B-WICH complex positively regulates rRNA expression		0
High	P32322	"Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2"	0	14.05	11	3	8	2	319	33.3	7.61		2	1	3		3	1	4	519833.8672	1563244.906	535229.6094	2837831.781	2	2	2	2		metabolic process;regulation of biological process;response to stimulus	mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding	"Pf01210, Pf03807, Pf14748"	5831	ENSG00000183010.16	PYCR1	17	Amino acid synthesis and interconversion (transamination)	Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism	0
High	P10599	Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3	0	8.138	24	2	8	2	105	11.7	4.92	1	1	2	1	2	2	3	1	2198353.813	3485363.25	3583772.75	4127290	2	2	2	2		cell communication;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;mitochondrion;nucleus	antioxidant activity;catalytic activity;protein binding;RNA binding	"Pf00085, Pf00462, Pf13098, Pf13899, Pf13905"	7295	ENSG00000136810.12	TXN	9	Interconversion of nucleotide di- and triphosphates; Protein repair; TP53 Regulates Metabolic Genes; The NLRP3 inflammasome; Oxidative Stress Induced Senescence; Detoxification of Reactive Oxygen Species	NOD-like receptor signaling pathway	0
High	Q8NFZ0	F-box DNA helicase 1 OS=Homo sapiens OX=9606 GN=FBH1 PE=1 SV=2	0	7.703	4	4	8	4	1043	117.6	8.25		1	3	3		1	4	3		935819.4844	1414644.234	1472803.266		4	4	4		cell death;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00580, Pf00646, Pf12937, Pf13086, Pf13245, Pf13361, Pf13538"	84893	ENSG00000134452.19	FBXO18	10			0
High	Q15046	Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3	0	11.267	8	5	8	5	597	68	6.35	1	1	2	4	1	1	2	4	1954761.141	2021111.75	1812381.031	2182685.813	4	3	3	3		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00152, Pf00587, Pf01336"	3735	ENSG00000065427.14	KARS	16	Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Aminoacyl-tRNA biosynthesis	0
High	O95816	BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1	0	10.816	23	3	8	3	211	23.8	6.7	2	1	2	3	2	1	2	3	1430785.766	1461625.266	1176045.797	1759854.125	3	4	3	3		metabolic process;regulation of biological process	cytosol	enzyme regulator activity;nucleotide binding;protein binding	Pf02179	9532	ENSG00000112208.11	BAG2	6	Regulation of HSF1-mediated heat shock response	Protein processing in endoplasmic reticulum	0
High	P14678	Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2	0	4.988	9	2	8	2	240	24.6	11.19	2	1	2	2	2	1	3	2	1899737.906	2088141.656	2636881.438	3368063.75	2	2	2	2		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf01423	6628	ENSG00000125835.18	SNRPB	20	SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region	Spliceosome; Systemic lupus erythematosus	0
High	P61619	Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens OX=9606 GN=SEC61A1 PE=1 SV=2	0	12.04	8	3	8	3	476	52.2	8.06		2	1	3		2	1	5	187081.1172	599051.125	1758621.719	5633713.563	2	2	3	3		cell growth;cell organization and biogenesis;response to stimulus;transport	cytosol;endoplasmic reticulum;membrane	protein binding	"Pf00344, Pf10559"	29927	ENSG00000058262.9	SEC61A1	3	ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane	Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection	0
High	Q15392	Delta(24)-sterol reductase OS=Homo sapiens OX=9606 GN=DHCR24 PE=1 SV=2	0	10.373	6	4	8	4	516	60.1	8.16			3	4			3	5		755462.3906	2168141.313	3661801.594		3	4	4		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus	catalytic activity;nucleotide binding;protein binding	Pf01565	1718	ENSG00000116133.11	DHCR24	1	Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol	Steroid biosynthesis; Metabolic pathways	0
High	Q15532	Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3	0	6.693	7	2	8	2	418	45.9	6.46	2	2	1	2	3	2	1	2	1373359.281	1574276.188	1166785.406	3017163	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	protein binding	Pf05030	6760	ENSG00000141380.13	SS18	18		Transcriptional misregulation in cancer	0
High	O94905	Erlin-2 OS=Homo sapiens OX=9606 GN=ERLIN2 PE=1 SV=1	0	10.555	13	4	8	2	339	37.8	5.62		1	3	4		1	3	4	350921.9375	1259783.117	3268929.969	2725710.031	2	4	4	4		metabolic process;regulation of biological process;response to stimulus;transport	cytosol;endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf01145	11160	ENSG00000147475.14	ERLIN2	8	ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by plasma membrane FGFR1 fusions		2
High	P84090	Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1	0	7.956	34	3	8	3	104	12.3	5.92	2	2	2	2	2	2	2	2	4569299.469	4292716.719	3757219.875	3502213	3	3	2	2	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process		DNA binding;nucleotide binding;protein binding;RNA binding	Pf01133	2079	ENSG00000100632.10	ERH	14			0
High	Q14974	Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2	0	9.563	5	4	8	4	876	97.1	4.78	1	1	4	2	1	1	4	2	313012.1016	548580.7891	884640.4531	944902.3125	2	3	3	3	Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	metal ion binding;protein binding;RNA binding;transporter activity	"Pf02985, Pf03810, Pf13513, Pf13646"	3837	ENSG00000108424.9	KPNB1	17	ISG15 antiviral mechanism;  NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Neutrophil degranulation; Regulation of cholesterol biosynthesis by SREBP (SREBF); Transport of Ribonucleoproteins into the Host Nucleus; Activation of DNA fragmentation factor	RNA transport	0
High	Q15436	Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2	0	14.048	7	4	8	3	765	86.1	7.08		3	4	1		3	4	1	208800.5313	869888.625	2720423.281	289645.5313	1	2	2	1		cell organization and biogenesis;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane	metal ion binding;protein binding	"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033"	10484	ENSG00000100934.14	SEC23A	14	"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation"	Protein processing in endoplasmic reticulum	0
High	P08865	40S ribosomal protein SA OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4	0	7.558	17	3	8	3	295	32.8	4.87	2	2	2	2	2	2	2	2	1320766.406	2403427.719	2538615.719	1785838.875	2	3	3	2		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;nucleus;ribosome	protein binding;receptor activity;RNA binding;structural molecule activity	Pf00318	3921	ENSG00000168028.13	RPSA	3	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P04062	Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA PE=1 SV=3	0	12.963	9	5	8	5	536	59.7	7.61			2	5			2	6	79411.99219		1214529.094	5706391.5	1		4	4		cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	membrane;organelle lumen;vacuole	catalytic activity;protein binding	Pf02055	2629	ENSG00000177628.15	GBA	1	Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis	Lysosome; Sphingolipid metabolism; Other glycan degradation; Metabolic pathways	0
High	Q9Y265	RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1	0	9.699	11	4	8	4	456	50.2	6.42	2		2	4	2		2	4	2511706.188	1259133.594	2431356.844	2850012.438	4	3	4	4		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00004, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07726, Pf13191, Pf13238, Pf13245, Pf13481"	8607	ENSG00000175792.11	RUVBL1	3	Ub-specific processing proteases; UCH proteinases; DNA Damage Recognition in GG-NER; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; Deposition of new CENPA-containing nucleosomes at the centromere	Wnt signaling pathway	0
High	Q08378	Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2	0	19.759	7	8	8	8	1498	167.3	5.44	8				8				1883835.469				5					metabolic process;regulation of biological process;transport	cytoplasm;cytosol;Golgi;membrane;nucleus	catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity	"Pf00038, Pf01576, Pf02463, Pf04111, Pf05557, Pf07888, Pf10186, Pf12128, Pf12325"	2802	ENSG00000090615.14	GOLGA3	12			0
High	Q9H0U3	Magnesium transporter protein 1 OS=Homo sapiens OX=9606 GN=MAGT1 PE=1 SV=1	0	5.963	7	3	7	3	335	38	9.63		1	1	3		1	1	5	66382.00781	1149211.102	840781.8906	10387223.25	1	3	3	3		metabolic process;transport	endoplasmic reticulum;membrane	catalytic activity;transporter activity	Pf04756	84061	ENSG00000102158.19	MAGT1	X	Asparagine N-linked glycosylation; Neutrophil degranulation; Miscellaneous transport and binding events		0
High	Q9Y4X5	E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2	0	14.236	12	6	7	6	557	64.1	5.08		1		6		1		6		1843265.969	1807757.953	2280762.969		4	4	4		metabolic process;regulation of biological process	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	Pf01485	25820	ENSG00000166233.14	ARIH1	15	ISG15 antiviral mechanism		0
High	P49368	T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4	0	12.664	13	5	7	5	545	60.5	6.49			3	4			3	4	273872.8125	653292.6563	1040713.656	1769302.438	1	4	3	4	Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;membrane	nucleotide binding;protein binding;RNA binding	Pf00118	7203	ENSG00000163468.14	CCT3	1	BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC		0
High	P26368	Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4	0	5.031	5	2	7	2	475	53.5	9.09	2	1	2	2	2	1	2	2	1121982.969	890979.2188	1771091.813	1755473.438	2	2	2	2		metabolic process;regulation of biological process;transport	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	11338	ENSG00000063244.12	U2AF2	19	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway	Spliceosome	0
High	O00159	Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4	0	11.506	5	5	7	5	1063	121.6	9.41			2	4			2	5	77513.85938		909763.3828	1792465.219	1		4	4		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding	"Pf00063, Pf06017"	4641	ENSG00000197879.14	MYO1C	17	Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation		0
High	P46977	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens OX=9606 GN=STT3A PE=1 SV=2	0	10.036	7	5	7	5	705	80.5	8.07			1	5			1	6	390772.9375		2427583.625	4208667.313	1		3	4		metabolic process	endoplasmic reticulum;membrane	catalytic activity;metal ion binding;protein binding	Pf02516	3703	ENSG00000134910.12	STT3A	11	Asparagine N-linked glycosylation	N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	Q6NXT1	Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2	0	16.852	30	4	7	4	300	32.5	6.28		4				7			299934.9375	2958451.625			1	2				regulation of biological process;transport	cytoplasm;nucleus	enzyme regulator activity;protein binding	"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857"	129138	ENSG00000100124.14	ANKRD54	22			0
High	A8CG34	Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3	0	6.064	4	4	7	4	1229	125	10.37		4	1	1		5	1	1	71808.3125	1869724.375	1112793.344	520145.3672	1	3	3	2												0
High	Q9Y285	Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3	0	16.082	9	4	7	4	508	57.5	7.8			3	4			3	4	172797.3281	354986.2988	1860289.891	3046961.406	1	2	3	3	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00152, Pf01409, Pf08279, Pf12802, Pf13463"	2193	ENSG00000179115.10	FARSA	19	Cytosolic tRNA aminoacylation	Aminoacyl-tRNA biosynthesis	0
High	Q9Y230	RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3	0	9.612	10	4	7	4	463	51.1	5.64	2	1	2	2	2	1	2	2	1150738.25	505831.125	998556.5313	1285375.781	3	2	3	3	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00004, Pf03796, Pf06068, Pf13481"	10856	ENSG00000183207.13	RUVBL2	19	HATs acetylate histones; Telomere Extension By Telomerase		0
High	Q13263	Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5	0	8.68	7	4	7	4	835	88.5	5.77	1	1	3	2	1	1	3	2	811611.8516	1198322.906	2579498.719	1269297.25	3	3	4	3		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	"Pf00628, Pf00643"	10155	ENSG00000130726.11	TRIM28	19	Generic Transcription Pathway		0
High	P33992	DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5	0	14.467	9	5	7	5	734	82.2	8.37			5	2			5	2	567797.0313	454650.3906	1772657.984	1495179.125	5	3	5	5		cell division;metabolic process	membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00493, Pf07728, Pf14551"	4174	ENSG00000100297.15	MCM5	22	M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins	DNA replication; Cell cycle	0
High	O00425	Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2	0	8.553	8	4	7	2	579	63.7	8.87	3	1	2	1	3	1	2	1	369828.5625	206794.3281	187742.9063		1	1	1			metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding;translation regulator activity	"Pf00013, Pf00076, Pf13014, Pf13893, Pf14259, Pf14611"	10643	ENSG00000136231.13	IGF2BP3	7	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA		0
High	Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=UGGT2 PE=1 SV=4	0	9.602	3	5	7	3	1516	174.6	6.89			1	5			1	6	53724.21875	83196.03125		1526680.328	1	1		3		metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;organelle lumen	catalytic activity;protein binding	"Pf01501, Pf06427"	55757	ENSG00000102595.19	UGGT2	13	ER Quality Control Compartment (ERQC)	Protein processing in endoplasmic reticulum	0
High	Q7L4I2	Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1	0	8.649	9	3	7	3	434	50.5	11.33	1	1	3	1	1	1	4	1	2116886.594	1513184.094	2266950.5	1037874.5	3	3	3	2				protein binding;RNA binding	Pf15477	65117	ENSG00000111011.17	RSRC2	12			0
High	Q92900	Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2	0	8.016	4	4	7	4	1129	124.3	6.61	4	1	1	1	4	1	1	1	1521716.469	1178763.828	542754.6875	668075.2188	4	4	3	3		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytosol;nucleus;spliceosomal complex	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf04851, Pf09416, Pf13086, Pf13087, Pf13245, Pf13604"	5976	ENSG00000005007.12	UPF1	19	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	mRNA surveillance pathway; RNA transport	0
High	O00422	Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1	0	3.979	13	3	7	3	153	17.6	9.35	2	1	2	1	2	1	3	1	1879951.938	1983782.438	1916030.688	1860868.781	3	3	3	3		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;nucleus	catalytic activity;protein binding;RNA binding	Pf06487	10284	ENSG00000150459.12	SAP18	13	HDACs deacetylate histones; NoRC negatively regulates rRNA expression	mRNA surveillance pathway; RNA transport	0
High	Q9NXV2	BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1	0	6.583	11	2	7	2	234	26.1	6.24		2	2	1		3	2	2	82689.85156	2794306.938	2737572.938	3044142.125	1	2	2	2	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process	cytoplasm;cytosol;nucleus	protein binding	Pf02214	54442	ENSG00000167977.8	KCTD5	16			0
High	Q9HC44	Vasculin-like protein 1 OS=Homo sapiens OX=9606 GN=GPBP1L1 PE=1 SV=1	0.007	1.923	1	1	7	1	474	52.3	6.84		1	1	1		2	2	3		1402624.031	1211169.453	4169906.813		1	1	1		metabolic process;regulation of biological process	nucleus	DNA binding	Pf15337	60313	ENSG00000159592.10	GPBP1L1	1			0
High	Q9NZ01	Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1	0	13.325	13	5	7	5	308	36	9.45			2	5			2	5	25743.02344	202171.1172	4322538.266	10003728.44	1	2	5	5		metabolic process	cytoplasm;endoplasmic reticulum;membrane;nucleus	catalytic activity;protein binding	Pf02544	9524	ENSG00000099797.13	TECR	19	Synthesis of very long-chain fatty acyl-CoAs	Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism	0
High	O75521	"Enoyl-CoA delta isomerase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4"	0	8.738	9	3	7	3	394	43.6	9		2	3	1		3	3	1	316902.0313	1758293.625	1366133.719	921831.0156	2	3	3	3		metabolic process	membrane;mitochondrion;organelle lumen	catalytic activity;protein binding	"Pf00378, Pf00887"	10455	ENSG00000198721.12	ECI2	6		Peroxisome; Fatty acid degradation	0
High	Q9H9A7	RecQ-mediated genome instability protein 1 OS=Homo sapiens OX=9606 GN=RMI1 PE=1 SV=3	0	7.649	6	3	7	3	625	70.1	4.96		2	2	1		3	3	1	19503.32422	1719488.813	1509921.125	1428709.5	1	2	2	2		metabolic process;regulation of biological process	nucleus	nucleotide binding;protein binding	"Pf01336, Pf08585"	80010	ENSG00000178966.16	RMI1	9	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Resolution of D-loop Structures through Holliday Junction Intermediates	Fanconi anemia pathway	0
High	Q9H3T3	Semaphorin-6B OS=Homo sapiens OX=9606 GN=SEMA6B PE=1 SV=4	0.003	2.462	3	1	7	1	888	95.2	8.48	1	1	1	1	2	3	1	1	5323982.844	8494857.75	3882166.156	8772630.188	2	2	2	2		cell differentiation;development	membrane	protein binding	"Pf01403, Pf01437"	10501	ENSG00000167680.15	SEMA6B	19		Axon guidance	0
High	P12268	Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2	0	7.897	13	5	7	5	514	55.8	6.9		3	3	1		3	3	1	90460.4375	20449056.58	1620160.875	817320.7344	1	4	3	2		cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00478, Pf00571, Pf00977, Pf01070, Pf03060"	3615	ENSG00000178035.11	IMPDH2	3	Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis	Purine metabolism; Metabolic pathways; Drug metabolism - other enzymes	0
High	P49336	Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1	0.001	3.426	5	2	7	2	464	53.3	8.57	2	1	1	1	2	1	2	2	349635.125	663485.0781	462766.6875	454527.5313	2	2	1	1		metabolic process;regulation of biological process	nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf07714"	1024	ENSG00000132964.11	CDK8	13	NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression		0
High	Q9BRJ7	Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1	0	8.462	22	4	7	4	211	23.3	8.91	3	1	2	1	3	1	2	1	736170.8516	832717.2656	792176.4375	1382728.672	3	3	3	4		regulation of biological process	nucleus	catalytic activity;protein binding;RNA binding		84309	ENSG00000168101.14	NUDT16L1	16		Proteoglycans in cancer	0
High	P61964	WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1	0	12.494	14	4	7	4	334	36.6	8.27		3	2	1		3	3	1	3786098.094	7065544.953	2846450.406	1319357.68	4	4	3	3	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding	"Pf00400, Pf08662, Pf11715"	11091	ENSG00000196363.9	WDR5	9	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation		0
High	Q8TBK6	Zinc finger CCHC domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZCCHC10 PE=1 SV=1	0	7.938	11	2	7	2	192	21	8.53		2	1	1		3	2	2	1350578.156	1415619.563	903450.3438	1219164.5	2	2	2	2	Met-loss+Acetyl [N-Term]			metal ion binding;protein binding	Pf13917	54819	ENSG00000155329.11	ZCCHC10	5			0
High	O76021	Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3	0	8.458	8	4	7	4	490	54.9	10.13	2	1	1	3	2	1	1	3	1640805.406	474128.5469	1917514.688	1811576.266	4	3	4	4		cell differentiation;metabolic process;regulation of biological process	membrane;nucleus	protein binding;RNA binding	"Pf06030, Pf11797"	26156	ENSG00000171490.12	RSL1D1	16			0
High	Q15637	Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4	0	10.106	9	4	7	4	639	68.3	8.98	2	2	1	2	2	2	1	2	2211049.781	1458849.375	1018706.125	1716509.594	4	3	3	3		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process	nucleus;ribosome;spliceosomal complex	metal ion binding;protein binding;RNA binding	"Pf00013, Pf00098, Pf13014"	7536	ENSG00000168066.20	SF1	11	mRNA Splicing - Major Pathway		0
High	P83881	60S ribosomal protein L36a OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2	0	4.169	16	2	7	2	106	12.4	10.58	2	1	2	1	2	1	3	1	2749834.375	4210297	3842024.688	2409402.125	2	2	2	2		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00935	6173	ENSG00000241343.9	RPL36A	X	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q00059	"Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1"	0	3.737	9	2	7	2	246	29.1	9.72		2	2	2		3	2	2	172288.832	1446193.188	589662.4531	823217.4688	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process	cytosol;mitochondrion;nucleus;organelle lumen	DNA binding;protein binding;RNA binding	"Pf00505, Pf09011"	7019	ENSG00000108064.10	TFAM	10	Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis	Huntington's disease	0
High	O00483	Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1	0	9.196	27	2	7	2	81	9.4	9.38		1	2	2		1	3	3	376751.2188	709444.5	1828875.313	4176540.75	1	1	2	2		metabolic process;transport	membrane;mitochondrion	catalytic activity;protein binding;transporter activity	Pf06522	4697	ENSG00000189043.9	NDUFA4	7	TP53 Regulates Metabolic Genes; Respiratory electron transport	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways	0
High	P45880	Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2	0	12.658	18	5	7	5	294	31.5	7.56			5	1			6	1	208334.2227	367843.8828	7340337.313	3821445.188	2	3	5	5		regulation of biological process;transport	membrane;mitochondrion;nucleus	nucleotide binding;protein binding;transporter activity	Pf01459	7417	ENSG00000165637.13	VDAC2	10	Mitochondrial calcium ion transport; Ub-specific processing proteases	NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway	0
High	Q14498	RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2	0	6.688	7	3	7	3	530	59.3	10.1	2	3	2		2	3	2		340150.8281	1058262.125	670782.9531		2	3	2		Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process	cytoskeleton;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259, Pf15519"	9584	ENSG00000131051.22	RBM39	20			0
High	Q15843	NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1	0	6.417	17	1	7	1	81	9.1	8.43		1	1	1		3	2	2	91453.04688	2035655.156	1967250.875	2545793.563	1	1	1	1		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	protein binding	"Pf00240, Pf11976"	4738	ENSG00000129559.12	NEDD8	14	Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; TGF-beta receptor signaling activates SMADs; Iron uptake and transport; Neddylation		0
High	P62314	Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1	0	6.99	37	3	7	3	119	13.3	11.56	1	1	1	3	1	1	1	4	1813193.672	1719827.098	2003911.367	2363507.969	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf01423	6632	ENSG00000167088.10	SNRPD1	18	snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome; Systemic lupus erythematosus	0
High	P60866	40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1	0	8.387	25	3	7	3	119	13.4	9.94	1	2		2	1	3		3	3173600.563	7580886.375	9755685.625	7563601.125	3	3	3	3		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;membrane;ribosome	protein binding;RNA binding;structural molecule activity	Pf00338	6224	ENSG00000008988.9	RPS20	8	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	P18850	Cyclic AMP-dependent transcription factor ATF-6 alpha OS=Homo sapiens OX=9606 GN=ATF6 PE=1 SV=3	0	10.356	7	4	6	4	670	74.5	8.22			2	3			2	4		66136.86719	437552.6797	1343861.438		1	3	3		metabolic process;regulation of biological process;response to stimulus	cytosol;endoplasmic reticulum;Golgi;membrane;nucleus	DNA binding;protein binding	"Pf00170, Pf03131, Pf06156, Pf07716"	22926	ENSG00000118217.5	ATF6	1	ATF4 activates genes; ATF6 (ATF6-alpha) activates chaperone genes	Protein processing in endoplasmic reticulum; Alzheimer's disease	0
High	O95399	Urotensin-2 OS=Homo sapiens OX=9606 GN=UTS2 PE=1 SV=1	0.009	1.868	6	1	6	1	124	14.3	7.8	1	1	1	1	1	2	1	2	4982719.5	15659597	5575668.5	36020384	1	1	1	1		cell communication;cellular homeostasis;regulation of biological process;response to stimulus	extracellular	protein binding	Pf02083	10911	ENSG00000049247.13	UTS2	1	Peptide ligand-binding receptors; Gastrin-CREB signalling pathway via PKC and MAPK		0
High	O75448	Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1	0	6.11	2	2	6	2	989	110.2	6.95		2	2	2		2	2	2	337787.3125	421099.1563	499462.3438	498712.6563	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	nucleus	protein binding;receptor activity	Pf11277	9862	ENSG00000008838.19	MED24	17	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
High	P06576	"ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3"	0	9.466	8	3	6	3	529	56.5	5.4	1	1	2	2	1	1	2	2	283912.875	239147.125	977588.6875	1639067.938	1	2	2	2		cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport	cell surface;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;transporter activity	"Pf00006, Pf00306, Pf02874"	506	ENSG00000110955.8	ATP5B	12	Transcriptional activation of mitochondrial biogenesis; Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Metabolic pathways	0
High	Q52LJ0	Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2	0	4.73	4	2	6	1	433	45.5	8.69	1	2	1	2	1	2	1	2	339415.1563	420137.0313	281223	432927.75	1	1	1	1												0
High	Q8TBC3	SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2	0	10.003	8	4	6	4	707	76.3	8.28	4				6				2352410.313	182338.7969		151380.2969	4	1		1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;regulation of biological process	vacuole	protein binding	Pf02214	92799	ENSG00000160410.14	SHKBP1	19			0
High	Q9BTY2	Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2	0	16.43	14	6	6	6	467	54	6.25				6				6		42368.23828	871655.9531	10860381.44		1	3	4		metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	catalytic activity;protein binding	Pf01120	2519	ENSG00000001036.13	FUCA2	6	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation	Other glycan degradation	0
High	P51659	Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3	0	9.015	7	4	6	4	736	79.6	8.84	3	1	1	1	3	1	1	1	2728449.313	1902758.297	1813226.469	1095182.281	4	4	4	3		cell differentiation;metabolic process	membrane;mitochondrion;organelle lumen	catalytic activity;protein binding	"Pf00106, Pf01575, Pf02036, Pf08659, Pf13452, Pf13561, Pf14864"	3295	ENSG00000133835.14	HSD17B4	5	Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids	Peroxisome; Metabolic pathways; Primary bile acid biosynthesis	0
High	Q13049	E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2	0	13.907	9	5	6	5	653	71.9	6.98	5	1			5	1			1921652.297	887948.4688	1136885.328	1089652.391	5	4	5	3	Met-loss+Acetyl [N-Term]	cell differentiation;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding;RNA binding	"Pf00097, Pf00643, Pf01436, Pf10186, Pf13445, Pf13639, Pf13920, Pf13923, Pf14570, Pf14634, Pf15227"	22954	ENSG00000119401.10	TRIM32	9	Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA	Ubiquitin mediated proteolysis	0
High	P38919	Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4	0	5.422	9	3	6	2	411	46.8	6.73	3	2	1		3	2	1		1136997.172	1258183.688	1592686.906	1455308	3	3	3	3		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;spliceosomal complex	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271"	9775	ENSG00000141543.9	EIF4A3	17	ISG15 antiviral mechanism; mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA	Spliceosome; mRNA surveillance pathway; RNA transport	1
High	P40227	T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3	0	5.68	7	4	6	4	531	58	6.68		1	2	3		1	2	3	513995.7422	368012.5938	510207.5938	388400.1563	2	1	1	1		metabolic process;regulation of biological process	cytoplasm;cytosol;membrane	nucleotide binding;protein binding;RNA binding	"Pf00118, Pf05504"	908	ENSG00000146731.10	CCT6A	7	Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC		0
High	P54136	"Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2"	0	6.402	4	3	6	3	660	75.3	6.68	2	1		3	2	1		3	1753243.438	2180956.25	1944577.094	2409506.438	3	3	3	3		metabolic process	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00750, Pf03485, Pf05746"	5917	ENSG00000113643.8	RARS	5	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Aminoacyl-tRNA biosynthesis	0
High	Q13155	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2	0	8.126	10	2	6	2	320	35.3	8.22		1	2	1		2	3	1	249326.0625	958710.5781	723360.4844	1173291.406	1	2	2	2		cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process	cytoplasm;cytosol;membrane;nucleus	protein binding;structural molecule activity	"Pf13410, Pf14497"	7965	ENSG00000106305.9	AIMP2	7	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins		0
High	P50897	Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1	0	15.279	23	5	6	5	306	34.2	6.52				5				6	118978.7422		289221.5781	1655568.313	1		2	2		cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen;vacuole	catalytic activity;protein binding	Pf02089	5538	ENSG00000131238.16	PPT1	1	Fatty acyl-CoA biosynthesis	Lysosome; Fatty acid elongation; Metabolic pathways; Fatty acid metabolism	0
High	Q15029	116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1	0	8.121	5	4	6	3	972	109.4	5	2		2	2	2		2	2	496198.25	350762.2188	348178.5938	422153.1875	2	1	1	1		cell organization and biogenesis;metabolic process;response to stimulus	cytosol;membrane;nucleus;spliceosomal complex	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492"	9343	ENSG00000108883.12	EFTUD2	17	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	P17812	CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2	0	9.348	5	3	6	3	591	66.6	6.46		1	2	3		1	2	3	461187.0117	955264.5703	1546427.375	2391954.234	3	3	3	3		cell proliferation;metabolic process;response to stimulus	cytosol;membrane	catalytic activity;nucleotide binding;protein binding	"Pf00117, Pf06418, Pf07722"	1503	ENSG00000171793.13	CTPS1	1	Interconversion of nucleotide di- and triphosphates	Metabolic pathways; Pyrimidine metabolism	0
High	Q02978	Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens OX=9606 GN=SLC25A11 PE=1 SV=3	0	17.886	17	4	6	4	314	34	9.91			2	3			2	4			2205696.809	4243523.938			4	4	Met-loss+Acetyl [N-Term]	metabolic process;transport	membrane;mitochondrion;nucleus	RNA binding;transporter activity	Pf00153	8402	ENSG00000108528.13	SLC25A11	17	Gluconeogenesis		0
High	P60891	Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2	0	4.899	7	2	6	2	318	34.8	6.98		2	2	2		2	2	2	399246.5391	780881.4688	908021.9688	1025643.281	2	2	2	2		metabolic process	cytosol	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00156, Pf13793, Pf14572"	5631	ENSG00000147224.10	PRPS1	X	5-Phosphoribose 1-diphosphate biosynthesis	Carbon metabolism; Purine metabolism; Pentose phosphate pathway; Biosynthesis of amino acids; Metabolic pathways	0
High	Q969V3	Nicalin OS=Homo sapiens OX=9606 GN=NCLN PE=1 SV=2	0	10.013	9	5	6	5	563	62.9	6.89			3	3			3	3		2265267.25	5155430.547	5373299.469		1	5	5		metabolic process;regulation of biological process	endoplasmic reticulum;membrane	protein binding	"Pf04389, Pf05450"	56926	ENSG00000125912.10	NCLN	19			0
High	Q96TA2	ATP-dependent zinc metalloprotease YME1L1 OS=Homo sapiens OX=9606 GN=YME1L1 PE=1 SV=2	0	8.516	8	5	6	5	773	86.4	8.76			2	4			2	4	51888.37891		813018.2813	1332451.188	1		4	4		cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport	membrane;mitochondrion	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00004, Pf01434"	10730	ENSG00000136758.18	YME1L1	10	Processing of SMDT1		0
High	Q5T749	Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1	0	7.558	12	3	6	3	579	64.1	8.27	1	2	2	1	1	2	2	1	1275119.641	1676519.906	692763.8594	534019.3594	2	2	2	2			cytoplasm	protein binding		448834	ENSG00000203786.6	KPRP	1			0
High	Q9Y4C2	TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3	0	9.134	5	5	6	5	921	102.1	6.54	1		2	3	1		2	3	1002721.109	690356.4219	976715.7656	1639117.156	4	3	3	4		regulation of biological process;transport	membrane	protein binding	Pf13402	9747	ENSG00000198420.9	FAM115A; TCAF1	7			0
High	Q53H96	Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3	0	10.666	14	3	6	3	274	28.6	7.72	3		2	1	3		2	1	1751700.375	306362.4375	521015.2578	786756.2813	2	1	2	2		metabolic process	cytoplasm;cytosol	catalytic activity;protein binding	"Pf03807, Pf14748"	65263	ENSG00000276657.2; ENSG00000104524.13	PYCRL; PYCR3	8; CHR_HSCHR8_3_CTG7	Amino acid synthesis and interconversion (transamination)	Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism	0
High	Q8TED9	Actin filament-associated protein 1-like 1 OS=Homo sapiens OX=9606 GN=AFAP1L1 PE=1 SV=2	0	7.882	5	3	6	3	768	86.4	6.8		1	3	2		1	3	2		781539.8281	974734.5625	1271984.938		3	3	3			cytoplasm	protein binding	Pf00169	134265	ENSG00000157510.13	AFAP1L1	5			0
High	P17980	26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3	0	7.367	9	3	6	3	439	49.2	5.24		1	2	3		1	2	3	197527.3203	277048.1328	625814.8594	804365.2344	2	2	3	3		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00004, Pf01078, Pf05496, Pf07724, Pf07728, Pf13191"	5702	ENSG00000165916.8	PSMC3	11	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Epstein-Barr virus infection; Proteasome	0
High	P08621	U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2	0	7.297	6	3	6	3	437	51.5	9.94	1	2	1	2	1	2	1	2	2474625.344	2082785.063	2883271.828	2574148.875	3	3	3	3		metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf12220, Pf13893, Pf14259"	6625	ENSG00000104852.14	SNRNP70	19	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q16629	Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1	0	7.33	13	3	6	3	238	27.4	11.82	2	2	1	1	2	2	1	1	2791026.063	2830315.5	3056954.563	3546128.688	3	3	3	3		metabolic process;regulation of biological process;transport	cytoplasm;nucleus	metal ion binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	6432	ENSG00000115875.18	SRSF7	2	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome; Herpes simplex infection	0
High	P55209	Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1	0	12.527	10	3	6	3	391	45.3	4.46		1	1	2		2	2	2	416747.4063	953422.4688	1880275.969	2280539.313	1	1	2	2		cell organization and biogenesis;metabolic process;regulation of biological process	membrane;nucleus	protein binding;RNA binding	Pf00956	4673	ENSG00000187109.13	NAP1L1	12			0
High	O15371	Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1	0	12.326	5	2	6	2	548	63.9	6.05	1	2	2	1	1	2	2	1	273547.0625	712827.7813	888477.4375	359653.9688	1	2	2	1		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;membrane	protein binding;RNA binding	Pf05091	8664	ENSG00000100353.17	EIF3D	22	"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition"	RNA transport	0
High	Q8N163	Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2	0	4.875	3	2	6	2	923	102.8	5.22	2	1	1	1	3	1	1	1	660235.5625	121578.1719	149939.6719	168058.125	2	1	1	1		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus;organelle lumen;spliceosomal complex	enzyme regulator activity;protein binding;RNA binding	"Pf14443, Pf14444"	57805	ENSG00000158941.16	CCAR2; KIAA1967	8	Regulation of HSF1-mediated heat shock response		0
High	O75477	Erlin-1 OS=Homo sapiens OX=9606 GN=ERLIN1 PE=1 SV=2	0	6.615	9	3	6	1	348	39.1	7.87		1	3	2		1	3	2																				0
High	Q99538	Legumain OS=Homo sapiens OX=9606 GN=LGMN PE=1 SV=1	0	17.478	16	5	6	5	433	49.4	6.55			2	4			2	4			2676430.938	2603205.625			3	5		metabolic process;regulation of biological process;response to stimulus	endosome;organelle lumen;vacuole	catalytic activity	Pf01650	5641	ENSG00000100600.14	LGMN	14	Vitamin D (calciferol) metabolism; MHC class II antigen presentation; Trafficking and processing of endosomal TLR	Lysosome; Antigen processing and presentation	0
High	Q6ZUT1	Uncharacterized protein NKAPD1 OS=Homo sapiens OX=9606 GN=NKAPD1 PE=1 SV=2	0	4.864	6	2	6	2	292	34.1	9.73	1	1	2	1	1	2	2	1	426728.7813	629194.625	588659.6875	550726.4375	1	1	1	1				protein binding		55216	ENSG00000150776.17	C11orf57; NKAPD1	11			0
High	P62318	Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1	0	9.419	25	2	6	2	126	13.9	10.32	1	1	1	1	2	1	2	1	2384828.219	2514058.188	3458689.875	3503818.313	2	2	2	2		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf01423	6634	ENSG00000100028.11	SNRPD3	22	SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region	Spliceosome; Systemic lupus erythematosus	0
High	Q5BKZ1	DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2	0	6.84	7	3	6	3	582	65.6	5.15	2	2		2	2	2		2	1027541.656	1082766.625	605831.1094	1042123.344	3	3	3	3		metabolic process;regulation of biological process	nucleus;spliceosomal complex	DNA binding;metal ion binding;protein binding;RNA binding	Pf04988	284695	ENSG00000162664.16	ZNF326	1			0
High	Q9P0T7	Transmembrane protein 9 OS=Homo sapiens OX=9606 GN=TMEM9 PE=1 SV=1	0	5.834	11	2	6	2	183	20.6	6.65			2	2			3	3			6229014.5	3383717.75			2	2		transport	endosome;membrane;vacuole		Pf05434	252839	ENSG00000116857.16	TMEM9	1			0
High	P07996	Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2	0	4.664	3	3	5	3	1170	129.3	4.94		1	2	2		1	2	2	3250797	5062184.156	4402962.094	5552122.063	1	2	3	3		cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endoplasmic reticulum;extracellular;organelle lumen	metal ion binding;protein binding	"Pf00090, Pf00093, Pf02412, Pf05735, Pf12947"	7057	ENSG00000137801.10	THBS1	15	Platelet degranulation ; Integrin cell surface interactions; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Defective B3GALTL causes Peters-plus syndrome (PpS); O-glycosylation of TSR domain-containing proteins; Signaling by PDGF; Syndecan interactions	TGF-beta signaling pathway; MicroRNAs in cancer; Rap1 signaling pathway; Phagosome; Focal adhesion; Malaria; Proteoglycans in cancer; p53 signaling pathway; Bladder cancer; ECM-receptor interaction; PI3K-Akt signaling pathway	0
High	Q9NVF7	F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1	0	7.259	7	2	5	2	368	41.1	9.55			2	1			3	2		683429.9375	1507107.375	1325161.75		1	1	1			chromosome	protein binding	Pf00646	23219	ENSG00000143756.11	FBXO28	1			0
Medium	O95477	Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3	0.04	1.2	0	1	5	1	2261	254.1	6.86	1	1	1	1	1	1	1	2	1232158.875	846261.0625	848303.5625	977041.4375	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;Golgi;membrane	catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity;transporter activity	"Pf00005, Pf12698, Pf13304, Pf13732"	19	ENSG00000165029.15	ABCA1	9	Defective ABCA1 causes Tangier disease; PPARA activates gene expression; HDL assembly	Fat digestion and absorption; ABC transporters	0
High	Q92545	Transmembrane protein 131 OS=Homo sapiens OX=9606 GN=TMEM131 PE=1 SV=3	0	3.805	2	2	5	2	1883	205	8.59	1	1		1	2	2		1	4579373.219	4536955.063	4009197.563	3799144.813	2	2	2	2			membrane		Pf12371	23505	ENSG00000075568.16	TMEM131	2			0
High	P17050	Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2	0	6.672	5	2	5	2	411	46.5	5.19			1	2			1	4			497566.8594	5431909.25			2	2		metabolic process	cytoplasm;vacuole	catalytic activity;protein binding	Pf02065	4668	ENSG00000198951.11	NAGA	22		Lysosome; Glycosphingolipid biosynthesis - globo and isoglobo series	0
High	O60568	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1	0	7.114	6	3	5	3	738	84.7	6.05	1			3	1			4	2115847.164	2770355.32	3040212.164	4218158.719	3	3	3	3		cell organization and biogenesis;metabolic process;response to stimulus	endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding;protein binding	Pf03171	8985	ENSG00000106397.11	PLOD3	7	Collagen biosynthesis and modifying enzymes	Lysine degradation; Other types of O-glycan biosynthesis	0
High	O14617	AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1	0.001	3.339	3	2	5	2	1153	130.1	8.48		1	2	2		1	2	2	243928.2422	324030.1484	501112.9063	552339.8438	2	2	2	2		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytoplasm;Golgi;membrane	transporter activity	"Pf01602, Pf06375"	8943	ENSG00000065000.15	AP3D1	19		Lysosome	0
High	Q9NVC6	Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2	0	6.775	4	3	5	3	651	72.8	7.44		1	3	1		1	3	1	400932.875	898302.4375	1475038.594	1160141.563	1	2	3	2		metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	protein binding;receptor activity	Pf10156	9440	ENSG00000042429.11	MED17	11	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
High	Q8N4V1	Membrane magnesium transporter 1 OS=Homo sapiens OX=9606 GN=MMGT1 PE=1 SV=1	0	3.457	18	1	5	1	131	14.7	9.16		1	1	1		2	2	1		663880.375	1026430.5	756401.625		1	1	1		transport	endoplasmic reticulum;endosome;Golgi;membrane	transporter activity	Pf10270	93380	ENSG00000169446.5	MMGT1	X	Miscellaneous transport and binding events		0
High	Q9Y2W1	Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2	0	6.899	4	3	5	3	955	108.6	10.15	3	1		1	3	1		1	680595.1406	724239.0469	551656.4531	617320.625	3	3	2	2		metabolic process;regulation of biological process;response to stimulus	nucleus	DNA binding;nucleotide binding;protein binding;receptor activity;RNA binding	Pf15440	9967	ENSG00000054118.13	THRAP3	1	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression		0
High	P49959	Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3	0	9.566	8	4	5	4	708	80.5	5.9		3	2			3	2		142519.3594	1665764.938	867716.8125	704272.2188	1	2	2	2		cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding	"Pf00149, Pf04152"	4361	ENSG00000020922.12	MRE11A; MRE11	11	G2/M DNA damage checkpoint; IRF3-mediated induction of type I IFN; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates	Homologous recombination; Non-homologous end-joining	0
High	Q99623	Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2	0	7.392	13	4	5	4	299	33.3	9.83		1		4		1		4	2085749.188	3330575.266	2665179.875	2739942.375	3	4	4	4		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;membrane;mitochondrion;nucleus	protein binding	Pf01145	11331	ENSG00000215021.8	PHB2	12	Processing of SMDT1		0
High	Q99832	T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2	0.001	3.012	3	2	5	2	543	59.3	7.65	1	2	1	1	1	2	1	1	352298	429860.9063	461770.9375	737667.6875	2	2	2	2		metabolic process;regulation of biological process;transport	cytoplasm;cytosol;mitochondrion	nucleotide binding;protein binding	Pf00118	10574	ENSG00000135624.15	CCT7	2	Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC		0
High	Q16630	Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2	0	7.094	11	4	5	4	551	59.2	7.15	4		1		4		1		1498261.813	1047878.688	1542620.453	1109459.781	4	3	4	3		cell organization and biogenesis;metabolic process	membrane;nucleus	protein binding;RNA binding	"Pf00076, Pf14259"	11052	ENSG00000111605.16	CPSF6	12	Signaling by cytosolic FGFR1 fusion mutants	mRNA surveillance pathway	0
High	O00567	Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4	0	5.8	4	2	5	2	594	66	9.19	1	1	1	2	1	1	1	2	254642.2656	195722.6563	318741.1563	485576.25	1	1	1	1		metabolic process	cytoplasm;membrane;nucleus	protein binding;RNA binding	"Pf01798, Pf08060, Pf08156"	10528	ENSG00000101361.16	NOP56	20	Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis; rRNA modification in the nucleus and cytosol	Ribosome biogenesis in eukaryotes	0
High	Q96N67	Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4	0	10.96	2	5	5	5	2140	242.4	6.8	5				5				2066651.438	283129.7578	395926.9219	472890.5781	4	2	2	3		cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus		protein binding	"Pf06920, Pf11878, Pf14429"	85440	ENSG00000116641.17	DOCK7	1	MET activates RAP1 and RAC1; Factors involved in megakaryocyte development and platelet production		0
High	P14618	Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4	0	6.43	8	4	5	4	531	57.9	7.84		4		1		4		1	553367.0234	1409856.563	1242322.328	1301793.875	4	4	4	4		cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport	cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00224, Pf02887"	5315	ENSG00000067225.17	PKM	15	Glycolysis; Neutrophil degranulation	Viral carcinogenesis; Central carbon metabolism in cancer; Carbon metabolism; Purine metabolism; Pyruvate metabolism; Type II diabetes mellitus; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Metabolic pathways	0
High	Q15437	Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2	0	6.19	3	2	5	1	767	86.4	6.89		2	2	1		2	2	1	231682.2344	317281.2813	674183.8125	389916.7188	1	1	1	1		transport	cytoplasm;cytosol;endoplasmic reticulum;membrane	metal ion binding;protein binding	"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033"	10483	ENSG00000101310.14	SEC23B	20		Protein processing in endoplasmic reticulum	0
High	P01599	Immunoglobulin kappa variable 1-17 OS=Homo sapiens OX=9606 GN=IGKV1-17 PE=1 SV=2	0.004	2.374	13	1	5	1	117	12.8	8.68		1	1	1		3	1	1		9950141.75	11566782.38	10453173.75		1	1	1		cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	"Pf00047, Pf07679, Pf07686, Pf13927"	28937	ENSG00000281978.1; ENSG00000240382.3	IGKV1-17	2; CHR_HG2290_PATCH	FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis		0
High	Q9Y277	Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1	0	10.479	24	5	5	5	283	30.6	8.66			5				5				2090410.125	197120.9375			4	2	Met-loss+Acetyl [N-Term]	cell communication;defense response;regulation of biological process;response to stimulus;transport	membrane;mitochondrion;nucleus	nucleotide binding;transporter activity	Pf01459	7419	ENSG00000078668.13	VDAC3	8	Mitochondrial calcium ion transport; Ub-specific processing proteases	Viral carcinogenesis; NOD-like receptor signaling pathway; Hepatitis B; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Calcium signaling pathway	0
High	Q12891	Hyaluronidase-2 OS=Homo sapiens OX=9606 GN=HYAL2 PE=1 SV=4	0	9.167	7	3	5	3	473	53.8	8.19			1	3			1	4			945553.3281	2852929.375			2	2		cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole	catalytic activity;enzyme regulator activity;protein binding;receptor activity	Pf01630	8692	ENSG00000068001.13	HYAL2	3	Hyaluronan uptake and degradation	Glycosaminoglycan degradation; Metabolic pathways	0
High	Q15648	Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4	0	5.503	2	2	5	2	1581	168.4	8.73	1	2	2		1	2	2		516088.6406	607507.125	711377.8438	645197.7188	2	2	2	2		cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;membrane;nucleus	catalytic activity;DNA binding;protein binding;receptor activity	Pf10744	5469	ENSG00000125686.11	MED1	17	"Nuclear Receptor transcription pathway; Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; RORA activates gene expression; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription"	Thyroid hormone signaling pathway; Endocrine resistance	0
High	Q96PU8	Protein quaking OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1	0	5.299	6	2	5	2	341	37.6	8.56	1	2	1	1	1	2	1	1	919563.4688	677770.3125	836213.7188	1158243.406	2	2	2	2		cell differentiation;development;metabolic process;regulation of biological process;transport	cytoplasm;nucleus	protein binding;RNA binding	"Pf00013, Pf13014"	9444	ENSG00000112531.16	QKI	6	Signaling by BRAF and RAF fusions		0
Medium	Q03001	Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4	0.018	1.601	0	1	5	1	7570	860.1	5.25	1	1	1	1	1	1	1	2	12956650	17654894	43121752	37040488	1	1	1	1		cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus	metal ion binding;protein binding	"Pf00307, Pf00435, Pf00681, Pf02187, Pf11971, Pf13499, Pf13833"	667		DST	6	Type I hemidesmosome assembly		0
High	P54274	Telomeric repeat-binding factor 1 OS=Homo sapiens OX=9606 GN=TERF1 PE=1 SV=3	0	8.246	12	3	5	3	439	50.2	6.37		1	2	2		1	2	2		462483.5625	660039.0313	752598.125		2	2	2		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;nucleus	catalytic activity;DNA binding;protein binding	"Pf00249, Pf08558"	7013	ENSG00000147601.13	TERF1	8	Meiotic synapsis; DNA Damage/Telomere Stress Induced Senescence; Packaging Of Telomere Ends		0
High	Q92522	Histone H1.10 OS=Homo sapiens OX=9606 GN=H1-10 PE=1 SV=1	0	4.08	5	2	5	2	213	22.5	10.76	1	1	2	1	1	1	2	1	838597.25	1182767.063	1200560.063	964161.6172	2	2	2	2		cell organization and biogenesis	chromosome;nucleus	DNA binding;protein binding;RNA binding	Pf00538	8971	ENSG00000184897.5	H1FX	3			0
High	Q14919	Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3	0	6.695	11	2	5	2	205	22.3	5.17		2	2	1		2	2	1		1571881	2506357	1166997.5		1	2	1		metabolic process;regulation of biological process	nucleus	DNA binding;protein binding	"Pf00125, Pf00808"	10589	ENSG00000175550.7	DRAP1	11	Signaling by NODAL; Signaling by Activin		0
High	Q9NWB6	Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1	0	3.986	5	2	5	2	273	33.2	10.35	1	1	2	1	1	1	2	1	821028.6563	340831.875	1308488.188	1016329.438	2	1	2	2		metabolic process;regulation of biological process	mitochondrion;nucleus	protein binding	Pf15346	55082	ENSG00000134884.13	ARGLU1	13			0
High	P60660	Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2	0	4.246	21	3	5	3	151	16.9	4.65	1	1	3		1	1	3		692200.25	1858720	1757600.844	1270626.875	2	3	3	3		cellular component movement	cytosol;membrane	catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity	"Pf00036, Pf13405, Pf13499"	4637	ENSG00000092841.18	MYL6	12	RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs	Vascular smooth muscle contraction; Oxytocin signaling pathway	0
High	O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1	0	3.429	5	2	5	2	478	50.7	9.1		2	2	1		2	2	1	368035.875	858269.625	1223063.109	1174945.547	2	2	2	2		cell division;cell organization and biogenesis;regulation of biological process	chromosome;cytoplasm;cytoskeleton;nucleus	DNA binding;metal ion binding;protein binding;RNA binding		7756	ENSG00000010244.18	ZNF207	17			0
High	P35222	Catenin beta-1 OS=Homo sapiens OX=9606 GN=CTNNB1 PE=1 SV=1	0	8.296	4	3	5	2	781	85.4	5.86	1		2	2	1		2	2	316554.3281	378746.7656	542139.4219	399871.375	2	2	2	2		cell communication;cell differentiation;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	DNA binding;protein binding;signal transducer activity	Pf00514	1499	ENSG00000168036.16	CTNNB1	3	"Beta-catenin phosphorylation cascade; CDO in myogenesis; Binding of TCF/LEF:CTNNB1 to target gene promoters; Apoptotic cleavage of cell adhesion  proteins; RUNX3 regulates WNT signaling; S37 mutants of beta-catenin aren't phosphorylated; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Ca2+ pathway; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Misspliced GSK3beta mutants stabilize beta-catenin; Adherens junctions interactions; Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability"	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Tight junction; Pathogenic Escherichia coli infection; Hippo signaling pathway; Rap1 signaling pathway; Endometrial cancer; Breast cancer; Colorectal cancer; Pathways in cancer; Prostate cancer; Thyroid hormone signaling pathway; HTLV-I infection; Melanogenesis; Wnt signaling pathway; Focal adhesion; Proteoglycans in cancer; Adherens junction; Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Thyroid cancer; Basal cell carcinoma; Signaling pathways regulating pluripotency of stem cells	0
High	Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1	0	10.064	19	4	5	4	270	29.7	5.1	2	1	1	1	2	1	1	1	222534.4531	407653.5938	657160.25	344245.9688	1	2	2	1		metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	protein binding;receptor activity	Pf10018	29079	ENSG00000136146.14	MED4	13	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
High	Q9BRL6	Serine/arginine-rich splicing factor 8 OS=Homo sapiens OX=9606 GN=SRSF8 PE=1 SV=1	0	3.615	5	2	5	2	282	32.3	11.72	2	1	1		3	1	1		1012789.188	1093887.938	1174903.563	1085310.969	2	2	2	2		metabolic process	cytosol;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10929	ENSG00000263465.4	SRSF8	11		Spliceosome; Herpes simplex infection	0
High	P61927	60S ribosomal protein L37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2	0.001	2.942	16	2	5	2	97	11.1	11.74		1	2	2		1	2	2	1490497.125	2346082.016	3719280.656	2588268.969	2	2	2	2	Met-loss [N-Term]	cell organization and biogenesis;metabolic process;transport	cytosol;ribosome	metal ion binding;RNA binding;structural molecule activity	Pf01907	6167	ENSG00000145592.13	RPL37	5	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	O95218	Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2	0	4.186	6	2	5	2	330	37.4	10.01	1		1	2	1		2	2	852228.8281	654293.8672	1058840.758	1238638.625	2	2	2	2		metabolic process;regulation of biological process	nucleus	metal ion binding;protein binding;RNA binding	Pf00641	9406	ENSG00000132485.13	ZRANB2	1			0
High	P30511	"HLA class I histocompatibility antigen, alpha chain F OS=Homo sapiens OX=9606 GN=HLA-F PE=1 SV=3"	0	8.938	8	3	5	1	346	39	5.57				3				5				322062				1		regulation of biological process;response to stimulus	cell surface;endoplasmic reticulum;membrane	protein binding	"Pf00129, Pf07654, Pf08205"	3134	ENSG00000204642.13	HLA-F	6	"Interferon alpha/beta signaling; ER-Phagosome pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC"	Viral carcinogenesis; Endocytosis; Allograft rejection; Epstein-Barr virus infection; Type I diabetes mellitus; Cell adhesion molecules (CAMs); HTLV-I infection; Phagosome; Autoimmune thyroid disease; Herpes simplex infection; Viral myocarditis; Graft-versus-host disease; Antigen processing and presentation	0
High	Q9BSD7	Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1	0	4.804	11	2	5	2	190	20.7	9.54		1	1	2		1	1	3	135568.0508	483420.5781	820363.4063	2243008.375	2	2	2	2		metabolic process;response to stimulus	membrane	catalytic activity;nucleotide binding;RNA binding	"Pf00004, Pf00910, Pf01583, Pf03029, Pf03266, Pf05496, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13238"	84284	ENSG00000135778.11	NTPCR	1		Purine metabolism; Thiamine metabolism; Metabolic pathways	0
High	P41091	Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3	0	8.757	6	2	5	2	472	51.1	8.4		1	2	2		1	2	2		222057.9531	681646.25	1089678.688		1	2	2		metabolic process;transport	cytoplasm;cytosol;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf03144, Pf09173"	1968	ENSG00000130741.10	EIF2S3	X	"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition"	RNA transport	0
High	Q13561	Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4	0	4.565	5	2	5	2	401	44.2	5.21	2		1	1	3		1	1	877943.5625	148029.6563	251459.3594	125712.9844	2	1	1	1		cell organization and biogenesis;cell proliferation;regulation of biological process;transport	chromosome;cytoplasm;cytoskeleton;cytosol;membrane	catalytic activity;motor activity;protein binding	Pf04912	10540	ENSG00000175203.15	DCTN2	12	COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR)	Huntington's disease; Vasopressin-regulated water reabsorption	0
High	P78347	General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2	0	6.35	4	4	5	4	998	112.3	6.39	3		2		3		2		1102439.969	116355.0859	422045.4844	145926.6875	3	1	2	1		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus	DNA binding;protein binding	Pf02946	2969	ENSG00000263001.5	GTF2I	7		Basal transcription factors; cGMP-PKG signaling pathway; Herpes simplex infection	0
High	Q6UWY0	Arylsulfatase K OS=Homo sapiens OX=9606 GN=ARSK PE=1 SV=1	0	9.678	13	5	5	5	536	61.4	8.92				5				5	92290.65625	92387.14844	165508.0156	3496355.031	1	1	1	4		metabolic process	extracellular;organelle lumen	catalytic activity;metal ion binding	"Pf00884, Pf01676"	153642	ENSG00000164291.16	ARSK	5	The activation of arylsulfatases; Glycosphingolipid metabolism		0
High	P00738	Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1	0	7.534	9	3	5	3	406	45.2	6.58			2	2			3	2		722796.5938	2059546.781	1305856.813		2	3	3		defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	antioxidant activity;catalytic activity;protein binding	Pf00089	3240	ENSG00000257017.8	HP	16	Neutrophil degranulation; Scavenging of heme from plasma		0
High	P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1	0	10.776	6	2	5	2	447	51.7	6.2		1	2	2		1	2	2	540698.9297	1132163.125	1522003.469	2472813.875	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytosol	catalytic activity;enzyme regulator activity;protein binding		5520	ENSG00000221914.9	PPP2R2A	8	Cyclin D associated events in G1; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Initiation of Nuclear Envelope Reformation; Cyclin A/B1/B2 associated events during G2/M transition	Dopaminergic synapse; Chagas disease (American trypanosomiasis); Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; mRNA surveillance pathway; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway	0
High	Q9BZM1	Group XIIA secretory phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G12A PE=1 SV=1	0	18.473	23	3	5	3	189	21.1	7.24				3				5				7985802.375				3		metabolic process;transport	cytoplasm;endoplasmic reticulum;extracellular;Golgi	catalytic activity;metal ion binding	Pf06951	81579	ENSG00000123739.10	PLA2G12A	4	Acyl chain remodelling of PI; Synthesis of PA; Acyl chain remodelling of PG; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC	Fat digestion and absorption; Ether lipid metabolism; Vascular smooth muscle contraction; Arachidonic acid metabolism; Linoleic acid metabolism; Pancreatic secretion; Glycerophospholipid metabolism; Ras signaling pathway; alpha-Linolenic acid metabolism; Metabolic pathways	0
High	P57088	Transmembrane protein 33 OS=Homo sapiens OX=9606 GN=TMEM33 PE=1 SV=2	0	4.296	9	2	5	2	247	28	9.7			2	2			2	3	81126.03125	194992.9063	1173317.875	1954042.188	1	1	2	2		cell organization and biogenesis;regulation of biological process;response to stimulus	endoplasmic reticulum;membrane;nucleus	protein binding;structural molecule activity	Pf03661	55161	ENSG00000109133.12	TMEM33	4			0
High	P11047	Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3	0	10.002	2	3	5	3	1609	177.5	5.12			2	3			2	3		42917.96094	1329876.969	1583948.469		1	3	3		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process	extracellular;organelle lumen	catalytic activity;motor activity;protein binding;structural molecule activity	"Pf00052, Pf00053, Pf00055, Pf00261, Pf01576, Pf05262, Pf05483, Pf05557, Pf05667, Pf05701, Pf06008, Pf08317, Pf10174, Pf11068, Pf12128, Pf12795, Pf13166, Pf13514, Pf13868"	3915	ENSG00000135862.5	LAMC1	1	ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions	Amoebiasis; Prion diseases; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway	0
High	Q8WVX9	Fatty acyl-CoA reductase 1 OS=Homo sapiens OX=9606 GN=FAR1 PE=1 SV=1	0	11.119	8	4	5	4	515	59.3	9.17			1	4			1	4	381617.9063	255305.6797	1450980.438	4264496.5	1	2	4	4		metabolic process	membrane;organelle lumen	catalytic activity	"Pf01370, Pf03015, Pf07993"	84188	ENSG00000197601.12	FAR1	11	Wax biosynthesis	Peroxisome	0
High	Q13308	Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2	0	6.545	3	3	5	3	1070	118.3	7.09			2	3			2	3	99248.51563	180405.5781	608395.6172	1182338.906	1	1	3	3		cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	membrane	catalytic activity;nucleotide binding;protein binding	"Pf00047, Pf00069, Pf07679, Pf07714, Pf13895, Pf13927, Pf14575"	5754	ENSG00000112655.15	PTK7	6			0
High	Q86V81	THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3	0	5.174	10	2	5	2	257	26.9	11.15	2		2		2		3		1178898.281	960384.6875	964949.1563	1154984.813	2	2	2	2	Met-loss+Acetyl [N-Term]	cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10189		ALYREF	17	mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Transport of the SLBP Dependant Mature mRNA; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA	Spliceosome; mRNA surveillance pathway; RNA transport; Herpes simplex infection	0
High	Q6UXM1	Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens OX=9606 GN=LRIG3 PE=2 SV=1	0	6.688	3	3	5	1	1119	123.4	6.19			1	3			1	4			86871.26563	201651.7031			1	1		development	membrane	protein binding	"Pf00047, Pf07679, Pf12799, Pf13306, Pf13855, Pf13895, Pf13927"	121227	ENSG00000139263.11	LRIG3	12			0
High	P39060	Collagen alpha-1(XVIII) chain OS=Homo sapiens OX=9606 GN=COL18A1 PE=1 SV=5	0	6.586	1	2	5	2	1754	178.1	6.01	1	1	1	2	1	1	1	2	374538.3438	362116.875	569073.0625	670475.25	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular;organelle lumen	metal ion binding;protein binding;structural molecule activity	"Pf01391, Pf01392, Pf06121, Pf06482, Pf13385"	80781	ENSG00000182871.14	COL18A1	21	Collagen degradation; Activation of Matrix Metalloproteinases; Integrin cell surface interactions; Laminin interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization	Protein digestion and absorption	0
High	P31153	S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1	0	5.196	7	2	5	2	395	43.6	6.48	1		2	2	1		2	2	538079.2813	532800.4063	866352.0313	1026833.469	2	2	2	2		cell organization and biogenesis;metabolic process	cytosol	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00438, Pf02772, Pf02773"	4144	ENSG00000168906.12	MAT2A	2	Methylation	Biosynthesis of amino acids; Metabolic pathways; Cysteine and methionine metabolism	0
High	P60842	Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1	0	8.01	8	2	5	1	406	46.1	5.48	1	2	1	1	1	2	1	1	197303.1406	345476.1875	530732.4375	796646.7813	1	1	1	2		metabolic process;regulation of biological process	cytoplasm;cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf04851"	1973	ENSG00000161960.14	EIF4A1	17	ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition	RNA transport	0
High	O95158	Neurexophilin-4 OS=Homo sapiens OX=9606 GN=NXPH4 PE=2 SV=3	0	8.594	12	3	5	3	308	33	9.86				3				5			100603.1016	3536001.625			1	3		regulation of biological process;response to stimulus	extracellular	protein binding	Pf06312	11247	ENSG00000182379.9	NXPH4	12			0
High	Q9H0D6	5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1	0	6.379	3	3	5	3	950	108.5	7.47	2	1	1	1	2	1	1	1	602921.1094	249703.6406	239988.5156	238569.0625	3	2	1	1		cell differentiation;metabolic process;regulation of biological process	membrane;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	Pf03159	22803	ENSG00000088930.7	XRN2	20	Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis	Ribosome biogenesis in eukaryotes; RNA degradation	0
High	Q8WVK2	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP27 PE=1 SV=1	0	6.176	17	2	5	2	155	18.8	11.62		2	1	2		2	1	2	681420.25	959972.9375	1317300.625	1152502.25	2	2	2	2		metabolic process	nucleus	protein binding	Pf08648	11017	ENSG00000124380.10	SNRNP27	2	mRNA Splicing - Major Pathway	Spliceosome	0
High	P13747	"HLA class I histocompatibility antigen, alpha chain E OS=Homo sapiens OX=9606 GN=HLA-E PE=1 SV=4"	0	10.791	12	3	5	2	358	40	5.83				3				5				417132.625				1												0
High	Q9BZX2	Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1	0	4	7	2	5	2	261	29.3	6.7	2	1	1	1	2	1	1	1	555857.0156	478774.6875	877771.2188	1392629.844	2	2	2	2		metabolic process	cytosol	catalytic activity;nucleotide binding	"Pf00485, Pf13207"	7371	ENSG00000143179.14	UCK2	1	Pyrimidine salvage	Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes	0
High	P61009	Signal peptidase complex subunit 3 OS=Homo sapiens OX=9606 GN=SPCS3 PE=1 SV=1	0	7.7	18	3	5	3	180	20.3	8.62				3				5				17832019.44				3		metabolic process;transport	endoplasmic reticulum;membrane	catalytic activity	Pf04573	60559	ENSG00000129128.12	SPCS3	4	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"	Protein export	0
High	Q6P3R8	Serine/threonine-protein kinase Nek5 OS=Homo sapiens OX=9606 GN=NEK5 PE=2 SV=1	0	6.929	3	1	5	1	708	81.4	8.87		1	1	1		1	2	2		5175330.5	3901766.75	4944431.5		1	1	1		metabolic process;regulation of biological process		catalytic activity;metal ion binding;nucleotide binding	"Pf00069, Pf07714, Pf14531"	341676	ENSG00000197168.11	NEK5	13			0
High	P52815	"39S ribosomal protein L12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2"	0	7.312	12	3	4	3	198	21.3	8.87			1	3			1	3	173492.4766	87222.55469	1193548.875	1174373.125	2	1	2	2		cell organization and biogenesis;metabolic process;regulation of biological process	membrane;mitochondrion;ribosome	protein binding;RNA binding;structural molecule activity	Pf00542	6182	ENSG00000262814.7	MRPL12	17	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination	Ribosome	0
High	P06280	Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1	0	6.742	10	3	4	3	429	48.7	5.6				3				4			383580.5	2040584.375			2	3		metabolic process;regulation of biological process;transport	cytoplasm;extracellular;Golgi;organelle lumen;vacuole	catalytic activity;protein binding	Pf02065	2717	ENSG00000102393.9	GLA	X	Glycosphingolipid metabolism; Neutrophil degranulation	Lysosome; Galactose metabolism; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis - globo and isoglobo series	0
High	P12532	"Creatine kinase U-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT1A PE=1 SV=1"	0	13.766	17	3	4	3	417	47	8.34	1	2		1	1	2		1	751001.375	1346509.063	682913.625	242516.625	2	2	1	1		metabolic process	membrane;mitochondrion	catalytic activity;nucleotide binding	"Pf00217, Pf02807"	1159; 548596	ENSG00000223572.9; ENSG00000237289.9	CKMT1B; CKMT1A	15	Creatine metabolism	Metabolic pathways; Arginine and proline metabolism	0
High	Q9NT22	EMILIN-3 OS=Homo sapiens OX=9606 GN=EMILIN3 PE=1 SV=2	0	7.05	6	3	4	3	766	82.6	7.72			3	1			3	1	38969.44531		936558.25	272065.4688	1		3	1		cell organization and biogenesis	cytoplasm;cytoskeleton;extracellular	protein binding	"Pf06160, Pf07546"	90187	ENSG00000183798.4	EMILIN3	20	Molecules associated with elastic fibres		0
High	Q14240	Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2	0	4.169	6	2	4	1	407	46.4	5.48	1	1	1	1	1	1	1	1	107183.5859	200164.6719	309855.7813	311955.5938	1	1	1	1		metabolic process;regulation of biological process	cytosol	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf04851"	1974	ENSG00000156976.16	EIF4A2	3	ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition	RNA transport	0
High	P53396	ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3	0	5.28	3	3	4	3	1101	120.8	7.33	3		1		3		1		686790.1875	129517.3359	206203.3906	103739.1016	3	1	1	1		metabolic process;regulation of biological process;transport	cytoplasm;cytosol;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00285, Pf00549, Pf02629, Pf08442"	47	ENSG00000131473.16	ACLY	17	ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Neutrophil degranulation	Citrate cycle (TCA cycle); Metabolic pathways	0
High	O95831	"Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1"	0.001	3.031	2	1	4	1	613	66.9	8.95	1	1	1	1	1	1	1	1	1902514	683299.375	1176988.875	2042362.75	1	1	1	1		cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00070, Pf07992, Pf14721, Pf14962"	9131	ENSG00000156709.13	AIFM1	X		Apoptosis	0
High	P51571	Translocon-associated protein subunit delta OS=Homo sapiens OX=9606 GN=SSR4 PE=1 SV=1	0	13.003	25	3	4	3	173	19	6.15				3				4		327015.2813	596668.625	14545549		1	1	2			endoplasmic reticulum;membrane		Pf05404	6748	ENSG00000180879.13	SSR4	X	SRP-dependent cotranslational protein targeting to membrane	Protein processing in endoplasmic reticulum	0
High	O75503	Ceroid-lipofuscinosis neuronal protein 5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2	0	8.934	15	4	4	4	358	41.5	7.4				4				4	315808.375			2031315.75	1			2		cell differentiation;cellular homeostasis;metabolic process;transport	cytosol;endoplasmic reticulum;Golgi;membrane;vacuole	protein binding	Pf15014	1203	ENSG00000102805.14	CLN5	13		Lysosome	0
High	Q9BVK6	Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TMED9 PE=1 SV=2	0	6.838	11	3	4	3	235	27.3	8.02			2	1			2	2		124718.0234	3099402.938	2729882.25		1	3	3		cell organization and biogenesis;regulation of biological process;transport	endoplasmic reticulum;Golgi;membrane	protein binding	Pf01105	54732	ENSG00000184840.11	TMED9	5	COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport		0
High	A8MT69	Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1	0	4.569	28	2	4	2	81	9	5.9		1	2	1		1	2	1		326208.0703	604066.6406	224100.6406		2	2	1		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	DNA binding;protein binding	Pf09415	201254	ENSG00000169689.14	STRA13; CENPX	17	Fanconi Anemia Pathway; Deposition of new CENPA-containing nucleosomes at the centromere	Fanconi anemia pathway	0
High	Q15149	Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3	0	6.303	1	3	4	3	4684	531.5	5.96	3				4				1509991.016	323319.3398	390093.9473	307178.9063	3	2	3	2		cell organization and biogenesis	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;RNA binding;structural molecule activity	"Pf00307, Pf00681, Pf03501, Pf07812"	5339	ENSG00000178209.14	PLEC	8	Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly		0
High	P62273	40S ribosomal protein S29 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2	0.007	1.906	13	1	4	1	56	6.7	10.13	1	1	1	1	1	1	1	1	563267.4375	773097.0625	1053210.875	846902.25	1	1	1	1		cell organization and biogenesis;metabolic process;transport	cytosol;ribosome	metal ion binding;structural molecule activity	Pf00253	6235	ENSG00000213741.9	RPS29	14	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
High	O14773	Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2	0	7.377	5	2	4	2	563	61.2	6.48			2	1			3	1	58451.4375	190426.2031	2802990.25	1129571.625	1	1	2	1		cell differentiation;cell organization and biogenesis;metabolic process	mitochondrion;organelle lumen;vacuole	catalytic activity;metal ion binding;protein binding	Pf09286	1200	ENSG00000166340.15	TPP1	11	XBP1(S) activates chaperone genes	Lysosome	0
High	P11802	Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2	0	4.009	8	2	4	1	303	33.7	7.01	1	1	1		2	1	1		356873.1563	270228.4375	282188.3438	438545.125	1	1	1	1		cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;membrane;nucleus	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00069, Pf01636, Pf07714"	1019	ENSG00000135446.16	CDK4	12	Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Ubiquitin-dependent degradation of Cyclin D1; Cyclin D associated events in G1; SCF(Skp2)-mediated degradation of p27/p21; Meiotic recombination; PTK6 Regulates Cell Cycle; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Transcriptional regulation by RUNX2; Oxidative Stress Induced Senescence	Viral carcinogenesis; T cell receptor signaling pathway; Tight junction; Hepatitis B; Pancreatic cancer; Chronic myeloid leukemia; Non-small cell lung cancer; Breast cancer; Pathways in cancer; Glioma; AGE-RAGE signaling pathway in diabetic complications; Melanoma; HTLV-I infection; p53 signaling pathway; Measles; Small cell lung cancer; Bladder cancer; Cell cycle; Endocrine resistance; PI3K-Akt signaling pathway	0
High	Q8TCJ2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens OX=9606 GN=STT3B PE=1 SV=1	0	8.106	5	3	4	3	826	93.6	8.91				3				4				1784545.875				2		metabolic process;response to stimulus	endoplasmic reticulum;membrane	catalytic activity;metal ion binding	"Pf02516, Pf13231"	201595	ENSG00000163527.9	STT3B	3		N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	Q96CW1	AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2	0	4.262	3	2	4	2	435	49.6	9.54		1	1	2		1	1	2	255123.0156	393406.1563	579600.4219	581834.125	2	2	2	2		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;membrane	protein binding;transporter activity	Pf00928	1173	ENSG00000161203.13	AP2M1	3	"Cargo recognition for clathrin-mediated endocytosis; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4"	Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle	0
High	P62306	Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1	0	6.503	50	3	4	3	86	9.7	4.67	2	1		1	2	1		1	241310.5156		272434.5938	468028.6875	1		1	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf01423	6636	ENSG00000139343.10	SNRPF	12	SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region	Spliceosome	0
High	P52701	DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2	0	4.731	2	3	4	3	1360	152.7	6.9			1	3			1	3	35563.07031	153343.2813	465053.5313	1332759.75	1	1	3	3		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytosol;Golgi;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192"	2956	ENSG00000116062.14	MSH6	2	Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	Colorectal cancer; Pathways in cancer; Mismatch repair; Platinum drug resistance	0
High	P46109	Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1	0	5.304	9	2	4	2	303	33.8	6.74		2	1	1		2	1	1	114411.7266	1039135.344	699545.9063	392121.75	1	2	2	2		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endosome	protein binding;RNA binding;signal transducer activity	"Pf00017, Pf00018, Pf07653, Pf14604"	1399	ENSG00000099942.12	CRKL	22	MET receptor recycling; Frs2-mediated activation; Regulation of signaling by CBL; MET activates RAP1 and RAC1; Downstream signal transduction	Insulin signaling pathway; MicroRNAs in cancer; Chronic myeloid leukemia; Neurotrophin signaling pathway; Rap1 signaling pathway; MAPK signaling pathway; ErbB signaling pathway; Pathways in cancer; Renal cell carcinoma; Focal adhesion; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Fc gamma R-mediated phagocytosis; Chemokine signaling pathway; Shigellosis	0
High	P49458	Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2	0	3.452	20	2	4	2	86	10.1	7.97	1	2	1		1	2	1		2022223.438	2223161.313	1716048.25	1132442	2	2	2	1		cell organization and biogenesis;regulation of biological process;transport	cytoplasm;cytosol	protein binding;RNA binding	Pf05486	6726; 653226	ENSG00000143742.12	SRP9; SRP9P1	1; 10	SRP-dependent cotranslational protein targeting to membrane	Protein export	0
High	Q14574	Desmocollin-3 OS=Homo sapiens OX=9606 GN=DSC3 PE=1 SV=3	0	6.852	6	3	4	3	896	99.9	6.1			3	1			3	1			1009472.547	661048.8984			3	3		cell death;regulation of biological process	cytoskeleton;membrane	metal ion binding;protein binding	"Pf00028, Pf01049, Pf08758"	1825	ENSG00000134762.16	DSC3	18	Formation of the cornified envelope		0
High	Q8IX12	Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2	0	3.563	2	2	4	2	1150	132.7	5.76	1	1	1	1	1	1	1	1	171159.125	109247.1094		111368.3984	1	1		1		cell death;metabolic process;regulation of biological process	cytoplasm	DNA binding;protein binding;RNA binding	"Pf02037, Pf14443, Pf14444"	55749	ENSG00000060339.13	CCAR1	10	mRNA Splicing - Major Pathway		0
High	P63241	Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2	0	7.06	25	3	4	3	154	16.8	5.24	1		3		1		3		480200.8906	694320.9531	1770477.094	444311	2	3	3	1		cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus	protein binding;RNA binding	Pf01287	1984	ENSG00000132507.17	EIF5A	17	Hypusine synthesis from eIF5A-lysine		0
High	Q15427	Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1	0.004	2.241	3	1	4	1	424	44.4	8.56	1	1	1	1	1	1	1	1	238475.8125	308186.3125	288398.7188	278334.4375	1	1	1	1		metabolic process;regulation of biological process	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	10262	ENSG00000143368.9	SF3B4	1	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	O00562	Membrane-associated phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNM1 PE=1 SV=4	0	4.574	2	3	4	2	1244	134.8	5.95		2	2			2	2			517124.125	394647.9688	529977.4844		2	2	2		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane	metal ion binding;protein binding;transporter activity	"Pf02121, Pf02862, Pf08235"	9600	ENSG00000110697.12	PITPNM1	11	Synthesis of PI		0
High	Q8NBL1	Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1	0	9.692	10	4	4	4	392	46.2	8.72				4				4			73364.11719	4103832.75			1	4		development;metabolic process;regulation of biological process	endoplasmic reticulum;organelle lumen	catalytic activity	Pf05686	56983	ENSG00000163389.10	POGLUT1	3	Pre-NOTCH Processing in the Endoplasmic Reticulum	Other types of O-glycan biosynthesis	0
High	P09429	High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3	0	4.027	13	2	4	2	215	24.9	5.74	1	1		2	1	1		2	237380.5938	232373.875	364519.7813	372980.5469	1	1	1	2		cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;chromosome;cytoplasm;endosome;extracellular;membrane;nucleus;organelle lumen	catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding	"Pf00505, Pf09011"	3146	ENSG00000189403.14	HMGB1	13	TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Neutrophil degranulation; Regulation of TLR by endogenous ligand; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activation of DNA fragmentation factor	Base excision repair	0
High	Q86X55	Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3	0	6.628	6	2	4	2	608	65.8	6.73	1	1	1	1	1	1	1	1	261756.5938	625389.0938	930893.5938	1405367.25	1	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;protein binding	"Pf02475, Pf05175, Pf05185, Pf06325, Pf08003, Pf08241, Pf08242, Pf11531, Pf12847, Pf13649, Pf13659, Pf13847"	10498	ENSG00000142453.11	CARM1	19	"Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression; PPARA activates gene expression; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription"	Endocrine resistance	0
High	Q12888	TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2	0	6.002	3	3	4	3	1972	213.4	4.7	1	1	1	1	1	1	1	1	613612.0313	773463.875	865650.9375	716840.0313	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;nucleus	DNA binding;protein binding	"Pf09038, Pf15057"	7158	ENSG00000067369.13	TP53BP1	15	G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ)	NOD-like receptor signaling pathway	0
High	Q09028	Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3	0.001	2.736	4	1	4	1	425	47.6	4.89	1	1	1	1	1	1	1	1	488728.375	428037.5625	570144.625	495590.75	1	1	1	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;DNA binding;protein binding	"Pf00400, Pf12265"	5928	ENSG00000162521.18	RBBP4	1	Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cyclin A:Cdk2-associated events at S phase entry; Deposition of new CENPA-containing nucleosomes at the centromere; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin E associated events during G1/S transition ; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; Activation of E2F1 target genes at G1/S; HDACs deacetylate histones; Transcription of E2F targets under negative control by DREAM complex; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation		0
High	O75607	Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3	0	10.412	18	2	4	2	178	19.3	4.63		1	2	1		1	2	1	1121404.094	480796.1875	1194889.938	797552.1875	2	2	2	2	Met-loss+Acetyl [N-Term]	metabolic process	cytoskeleton;cytosol;nucleus	protein binding;RNA binding	"Pf02087, Pf03066"	10360	ENSG00000107833.10	NPM3	10			0
High	Q08554	Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2	0	5.389	3	2	4	2	894	99.9	5.43	1	2	1		1	2	1		494091.0938	1230275.938	321126.2813	837747.8594	2	2	2	2		cell death;transport	cytoskeleton;membrane	metal ion binding	"Pf00028, Pf01049, Pf08758"	1823	ENSG00000134765.9	DSC1	18	Formation of the cornified envelope; Neutrophil degranulation		0
High	O43813	Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1	0	4.325	7	2	4	2	399	45.3	7.75	1		1	2	1		1	2	486128.1641	464946.3828	480077.1563	779112.9688	2	2	1	2		regulation of biological process;response to stimulus	cytoplasm;membrane	metal ion binding;protein binding;receptor activity;signal transducer activity	Pf05147	10314	ENSG00000115365.11	LANCL1	2			0
High	O15260	Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3	0	10.507	16	3	4	3	269	30.4	7.78			1	3			1	3		66799.72656	374157	748064.2344		1	1	2	Met-loss [N-Term]	cell organization and biogenesis;regulation of biological process;transport	endoplasmic reticulum;Golgi;membrane	protein binding	Pf02077	6836	ENSG00000280951.2; ENSG00000148248.13	SURF4	9; CHR_HG2030_PATCH	COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation		0
High	Q8NC51	Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2	0	4.73	4	1	4	1	408	44.9	8.65	1	1	1	1	1	1	1	1	340019.375	726200.3125	1485979.25	851773.125	1	1	1	1	Met-loss [N-Term]	regulation of biological process	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	Pf04774	26135	ENSG00000142864.14	SERBP1	1			0
High	Q9NR28	"Diablo homolog, mitochondrial OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1"	0	5.894	9	2	4	2	239	27.1	5.9		1	2	1		1	2	1			4037070.25	8124162			1	1		cell death;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;mitochondrion	protein binding	Pf09057	56616	ENSG00000184047.16	DIABLO	12	SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Release of apoptotic factors from the mitochondria	Apoptosis - multiple species; Apoptosis	0
High	O75165	DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5	0	4.239	1	2	4	2	2243	254.3	6.74	2	1	1		2	1	1		1065154.313	350502.4297	392698.7656	324572.75	2	2	2	1		cell differentiation;cell organization and biogenesis;regulation of biological process;transport	cytosol;endosome;membrane	protein binding	"Pf00226, Pf14237"	23317	ENSG00000138246.15	DNAJC13	3	Neutrophil degranulation		0
High	Q8TD19	Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2	0	8.892	5	4	4	4	979	107.1	5.74	4				4				2197365.281	75310.74219	85106.10938		4	1	1			cell division;cell organization and biogenesis;metabolic process	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00069, Pf00415, Pf07714, Pf13540, Pf14531"	91754	ENSG00000119638.12	NEK9	14	"Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly"		0
High	Q96JJ7	Protein disulfide-isomerase TMX3 OS=Homo sapiens OX=9606 GN=TMX3 PE=1 SV=2	0	7.943	11	4	4	4	454	51.8	4.91				4				4				2255259.719				3		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;membrane	catalytic activity;metal ion binding;protein binding	"Pf00085, Pf01216, Pf13098, Pf13848, Pf13899"	54495	ENSG00000166479.9	TMX3	18	Platelet degranulation		0
High	Q9H3H9	Transcription elongation factor A protein-like 2 OS=Homo sapiens OX=9606 GN=TCEAL2 PE=2 SV=1	0.003	2.443	4	1	4	1	227	25.8	5.94	1	1	1	1	1	1	1	1	666808.875	456377.7188	555849.25	828691.5	1	1	1	1		metabolic process;regulation of biological process	nucleus	protein binding	Pf04538	140597	ENSG00000184905.8	TCEAL2	X			0
High	P63220	40S ribosomal protein S21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1	0.001	3.291	22	1	4	1	83	9.1	8.5	1	1	1	1	1	1	1	1	246200.7813	491993.3125	416452.5313	195646.2656	1	1	1	1		cell organization and biogenesis;metabolic process;transport	cytosol;ribosome	protein binding;RNA binding;structural molecule activity	Pf01249	6227	ENSG00000171858.17	RPS21	20	"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane"	Ribosome	0
Medium	P98196	Probable phospholipid-transporting ATPase IH OS=Homo sapiens OX=9606 GN=ATP11A PE=1 SV=3	0.036	1.273	1	1	4	1	1134	129.7	6.6		1	1	1		1	1	2	2802420.25	1981793.5	1922174	2720575.25	1	1	1	1		cell organization and biogenesis;transport	endoplasmic reticulum;endosome;membrane	catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity	"Pf00122, Pf00702, Pf08282, Pf13206, Pf13246"	23250	ENSG00000068650.18	ATP11A	13	Neutrophil degranulation; Ion transport by P-type ATPases		0
High	Q96JA1	Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Homo sapiens OX=9606 GN=LRIG1 PE=1 SV=2	0	4.339	3	2	4	1	1093	119	7.09			2	1			2	2											membrane	protein binding	"Pf00047, Pf07679, Pf07686, Pf08205, Pf12799, Pf13855, Pf13895, Pf13927, Pf15369"	26018	ENSG00000282243.1; ENSG00000144749.13	LRIG1	3; CHR_HG2235_PATCH	Negative regulation of MET activity; Signaling by EGFR		0
High	P01023	Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3	0.001	2.994	1	2	4	2	1474	163.2	6.46		1	1	2		1	1	2	34574.02734	206086.4844	433103.625	2315486.906	1	1	1	2		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular;organelle lumen	enzyme regulator activity;protein binding	"Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249"	2	ENSG00000175899.14	A2M	12	Platelet degranulation ; Degradation of the extracellular matrix; Rho GTPase cycle; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation	Complement and coagulation cascades	0
High	Q9Y251	Heparanase OS=Homo sapiens OX=9606 GN=HPSE PE=1 SV=2	0	8.285	10	4	4	4	543	61.1	9.28			3	1			3	1	337799	441500.2813	2795665.5	926766.7578	1	1	4	3		metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;nucleus;organelle lumen;vacuole	catalytic activity;protein binding	Pf03662	10855	ENSG00000173083.14	HPSE	4	HS-GAG degradation; Neutrophil degranulation	Glycosaminoglycan degradation; Proteoglycans in cancer; Metabolic pathways	0
High	Q16531	DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1	0	5.267	5	3	4	3	1140	126.9	5.26			1	3			1	3	882139.6875	1294620.094	939070.6875	2043677.125	3	3	3	3		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	DNA binding;protein binding	"Pf03178, Pf10433"	1642	ENSG00000167986.13	DDB1	11	Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation	Viral carcinogenesis; Hepatitis B; Ubiquitin mediated proteolysis; Nucleotide excision repair	0
High	Q8TF42	Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2	0	7.416	5	3	4	3	649	72.6	6.93			3	1			3	1		267713.6328	718858.4219	524817.2188		2	2	2		metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	catalytic activity;protein binding	"Pf00018, Pf00300, Pf00627, Pf13563, Pf14604"	84959	ENSG00000154127.9	UBASH3B	11			0
High	Q05519	Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1	0	5.34	8	2	4	2	484	53.5	10.52	1	1	2		1	1	2		289767.375	439967.6563	568372.75	296093.2813	1	1	1	1		metabolic process;transport	nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	9295	ENSG00000116754.13	SRSF11	1	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway		0
High	Q5VTL8	Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1	0	4.329	4	2	4	2	546	64.4	10.54	1		2	1	1		2	1	199042.7031	200316.8438	556554.6563	378115.2656	1	1	2	2		metabolic process	nucleus;spliceosomal complex	RNA binding	Pf03371	55119	ENSG00000134186.11	PRPF38B	1		Spliceosome	0
High	Q5SRE5	Nucleoporin NUP188 homolog OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1	0	6.124	2	3	4	3	1749	195.9	6.73			3	1			3	1		288841.4551	609152.0156	984438.9531		3	3	3	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	membrane;nucleus	structural molecule activity	"Pf10487, Pf11894"	23511	ENSG00000095319.14	NUP188	9	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
Medium	Q01085	Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1	0.015	1.688	2	1	4	1	375	41.6	7.74	1	1	1	1	1	1	1	1	189245.3906	244752.0625	179554.375	393120.5938	1	1	1	1		cell death;cell division;defense response;regulation of biological process;response to stimulus	cytoplasm;nucleus;vacuole	DNA binding;RNA binding	"Pf00076, Pf13893, Pf14259"	7073	ENSG00000151923.17	TIAL1	10	FGFR2 alternative splicing		0
High	Q13435	Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2	0.001	3.051	2	2	4	2	895	100.2	5.67	2	1	1		2	1	1		385235.0469	507030.0313	513985.3906	205483.0156	2	2	2	1		metabolic process	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf02037, Pf04037, Pf04046"	10992	ENSG00000087365.15	SF3B2	11	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	Q9P035	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2	0	7.675	12	3	4	3	362	43.1	8.94			2	2			2	2	33665.70313	72850.0625	2776655.813	1948669.281	1	1	3	3		metabolic process;regulation of biological process;response to stimulus	cytosol;endoplasmic reticulum;membrane;mitochondrion	catalytic activity;enzyme regulator activity;protein binding	"Pf04387, Pf04969"	51495	ENSG00000074696.12	PTPLAD1; HACD3	15	Synthesis of very long-chain fatty acyl-CoAs	Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism	0
High	Q9Y6G9	Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3	0	7.125	8	3	4	3	523	56.5	6.42	1		2	1	1		2	1	456947.625	290601.7188	336458.125	389976.0625	1	1	1	1		cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport	chromosome;cytoplasm;cytoskeleton;cytosol;membrane	catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding	"Pf00005, Pf05783"	51143	ENSG00000144635.8	DYNC1LI1	3	COPI-independent Golgi-to-ER retrograde traffic; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR)	Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption	0
Medium	Q3KQU3	MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1	0.011	1.76	1	1	4	1	841	92.8	10.11		1	1	1		1	2	1	333720.0625	493136.25	357709.375	388226.5313	1	1	1	1		cell organization and biogenesis	cytoplasm;cytoskeleton;cytosol	structural molecule activity		55700	ENSG00000116871.15	MAP7D1	1			0
High	O00469	"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens OX=9606 GN=PLOD2 PE=1 SV=2"	0	7.31	5	3	3	3	737	84.6	6.71			2	1			2	1		41466.00391	511669.0938	406863.9375		1	1	1		metabolic process;response to stimulus	endoplasmic reticulum;membrane	catalytic activity;metal ion binding	Pf03171	5352	ENSG00000152952.11	PLOD2	3	Collagen biosynthesis and modifying enzymes	Lysine degradation	0
High	Q07065	Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2	0	5.831	8	3	3	3	602	66	5.92		1	2			1	2		301055.5391	398195.375	605033.7031	729899.7344	2	2	2	2		metabolic process;transport	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;organelle lumen	RNA binding	Pf13166	10970	ENSG00000136026.13	CKAP4	12	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Surfactant metabolism; Neutrophil degranulation	Protein processing in endoplasmic reticulum	0
High	O75600	"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1"	0.003	2.539	2	1	3	1	419	45.3	8.05		1	1	1		1	1	1		170231.3438	348096.2188	419223.5		1	1	1		metabolic process	membrane;mitochondrion;nucleus	catalytic activity	"Pf00155, Pf00266"	23464	ENSG00000100116.16	GCAT	22	Threonine catabolism	"Glycine, serine and threonine metabolism"	0
High	P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2	0	5.77	10	3	3	3	404	45.5	5.07	3				3				393706.875				1					coagulation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00027, Pf02197"	5576	ENSG00000114302.15	PRKAR2A	3	DARPP-32 events; ROBO receptors bind AKAP5; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; PKA activation in glucagon signalling; PKA activation	Insulin signaling pathway	0
High	Q6P4A7	Sideroflexin-4 OS=Homo sapiens OX=9606 GN=SFXN4 PE=1 SV=1	0	4.683	4	1	3	1	337	38	9.19			1	1			1	2			245251.4844	518067.5625			1	1		transport	membrane;mitochondrion	transporter activity	Pf03820	119559	ENSG00000183605.16	SFXN4	10			0
High	Q9UG63	ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2	0	6.765	6	3	3	3	623	71.2	7.37			1	2			1	2	85286.07031	111851.2656	641296.6875	943739.7813	1	1	2	2		transport	membrane;mitochondrion	catalytic activity;nucleotide binding;transporter activity	"Pf00005, Pf12848"	10061	ENSG00000033050.7	ABCF2	7			0
High	Q9NPA3	Mid1-interacting protein 1 OS=Homo sapiens OX=9606 GN=MID1IP1 PE=1 SV=1	0	4.044	17	2	3	2	183	20.2	5.5	2				3				502581.3438				1					cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;nucleus	protein binding	Pf07084	58526	ENSG00000165175.15	MID1IP1	X	Import of palmitoyl-CoA into the mitochondrial matrix		0
High	Q9BUE0	Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1	0.001	2.867	10	2	3	2	208	23.6	6.54			2	1			2	1	677079.375	768874.5938	879673.9375	894437.5313	2	2	2	2		metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding	Pf09637	54797	ENSG00000130772.13	MED18	1	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression		0
High	P62316	Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1	0.004	2.112	8	1	3	1	118	13.5	9.91	1	1	1		1	1	1		988532.1875	1165499.75	1577681.125	1353401	1	1	1	1		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf01423	6633	ENSG00000125743.10	SNRPD2	19	snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	P52434	"DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4"	0.005	2.056	4	1	3	1	150	17.1	4.68	1	1	1		1	1	1		144154.5938	358670.0625	341393.6563	372765.8281	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;DNA binding	Pf03870	5437	ENSG00000163882.9	POLR2H	3	Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter	Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism	0
High	P35580	Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3	0	3.438	1	2	3	2	1976	228.9	5.54		2	1			2	1			296170.2422	126607.5156	162892.2813		2	1	1		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity	"Pf00063, Pf00769, Pf01496, Pf01576, Pf02736, Pf04111, Pf05622, Pf05911, Pf06637, Pf07888, Pf09726, Pf12128, Pf13094, Pf13514"	4628	ENSG00000133026.12	MYH10	17	RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs	Tight junction; Salmonella infection; Regulation of actin cytoskeleton	0
High	Q8TED1	Probable glutathione peroxidase 8 OS=Homo sapiens OX=9606 GN=GPX8 PE=1 SV=2	0	3.616	9	2	3	2	209	23.9	9.35				2				3	17868.16992		168338.4414	873226.0938	1		2	2		metabolic process;response to stimulus	membrane;organelle lumen	antioxidant activity;catalytic activity	"Pf00255, Pf00578"	493869	ENSG00000164294.13	GPX8	5	Detoxification of Reactive Oxygen Species	Glutathione metabolism; Arachidonic acid metabolism; Thyroid hormone synthesis	0
High	Q15291	Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2	0	3.609	4	2	3	2	538	59.1	5.1		1	2			1	2		59468.03516	630244.4844	537619.8125	489463.4531	1	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;protein binding	Pf00400	5929	ENSG00000117222.13	RBBP5	1	Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex; Neddylation		0
High	Q9UBF6	RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1	0.004	2.188	8	1	3	1	113	12.7	5.44	1		1	1	1		1	1	626609.75	754144.6875	644986.75	1368881	1	1	1	1		metabolic process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	"Pf12678, Pf12861, Pf13639"	9616	ENSG00000114125.13	RNF7	3	Antigen processing: Ubiquitination & Proteasome degradation; Neddylation	Ubiquitin mediated proteolysis	0
High	Q13148	TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1	0	4.521	4	1	3	1	414	44.7	6.19		1	1	1		1	1	1	380831.9688	315377.3438	459512.5313	580281.9375	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	DNA binding;protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	23435	ENSG00000120948.16	TARDBP	1			0
High	Q9H7D7	WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3	0	8.726	5	2	3	2	661	72.1	6.16		2		1		2		1	67980.4375	120577.1563			1	1					cytoplasm;cytosol	protein binding	"Pf00400, Pf08662"	80232	ENSG00000162923.14	WDR26	1			0
High	P30837	"Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=3"	0	8.567	7	3	3	3	517	57.2	6.8				3				3	742152.3906	283682	469998.3281	2056114.125	3	2	2	3		metabolic process	mitochondrion;organelle lumen	catalytic activity;nucleotide binding	Pf00171	219		ALDH1B1	9	Ethanol oxidation	"Fatty acid degradation; Ascorbate and aldarate metabolism; Lysine degradation; Histidine metabolism; beta-Alanine metabolism; Pyruvate metabolism; Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Metabolic pathways; Tryptophan metabolism; Arginine and proline metabolism; Valine, leucine and isoleucine degradation"	0
High	P54886	Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2	0.001	2.915	1	1	3	1	795	87.2	7.12	1	1		1	1	1		1	216688.625	216511.0313	167413.5	319276.9688	1	1	1	1		metabolic process	cytoplasm;cytosol;membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00171, Pf00696"	5832	ENSG00000059573.8	ALDH18A1	10	Amino acid synthesis and interconversion (transamination)	Biosynthesis of amino acids; Metabolic pathways; Arginine and proline metabolism	0
High	Q5W0B1	ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1	0.001	3.127	4	2	3	2	726	81.1	5.72	1	1		1	1	1		1	270448.7188	173716.125	177523.8594	225051.7344	1	1	1	1				metal ion binding;protein binding	"Pf00097, Pf12678, Pf13639, Pf13920, Pf13923"	79596	ENSG00000152193.7	RNF219	13			0
High	Q9BQ67	Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1	0	6.201	9	3	3	3	446	49.4	4.92			3				3		839204.8828	478262.9844	1791728.438	526208.0781	3	2	3	2		cell organization and biogenesis;metabolic process	chromosome;cytosol;nucleus	DNA binding;protein binding;RNA binding	"Pf00400, Pf12265"	83743	ENSG00000105447.12	GRWD1	19			0
High	P20618	Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2	0	5.792	10	2	3	2	241	26.5	8.13			1	2			1	2		303820.0156	377897.4375	887814.75		2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome	catalytic activity;protein binding	Pf00227	5689	ENSG00000008018.8	PSMB1	6	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	Q04724	Transducin-like enhancer protein 1 OS=Homo sapiens OX=9606 GN=TLE1 PE=1 SV=2	0	5.335	3	2	3	2	770	83.1	7.24	2				3				1370167.781				2					development;metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	protein binding	"Pf00400, Pf03920"	7088	ENSG00000196781.14	TLE1	9	NOTCH1 Intracellular Domain Regulates Transcription; Repression of WNT target genes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex		0
High	Q9NS73	MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2	0	3.553	9	2	3	2	344	39.3	7.24		2	1			2	1		29048.07422	536185.6094	567596.5625	70819.74219	1	2	2	1		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;nucleus	catalytic activity;enzyme regulator activity;protein binding		51562	ENSG00000151332.18	MBIP	14	HATs acetylate histones		0
High	P09496	Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1	0.002	2.63	6	2	3	2	248	27.1	4.51	1	1		1	1	1		1	930572.7188	474981	298100.1563	468570.9688	2	1	1	1		cell division;cell organization and biogenesis;cellular component movement;metabolic process;transport	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;structural molecule activity	Pf01086	1211	ENSG00000122705.16	CLTA	9	"Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4"	Lysosome; Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle	0
Medium	Q7Z5H4	Vomeronasal type-1 receptor 5 OS=Homo sapiens OX=9606 GN=VN1R5 PE=2 SV=2	0.031	1.317	2	1	3	1	357	40.8	9.2		1	1	1		1	1	1	98710.88281	1378482.25	2306228.75	2114194.25	1	1	1	1		regulation of biological process;response to stimulus	membrane	receptor activity;signal transducer activity	Pf03402	317705		VN1R5	1			0
High	P28300	Protein-lysine 6-oxidase OS=Homo sapiens OX=9606 GN=LOX PE=1 SV=2	0	6.744	7	2	3	2	417	46.9	8.09			1	2			1	2			163655.1719	1224585.688			1	2		cell organization and biogenesis;metabolic process;response to stimulus	extracellular;nucleus	catalytic activity;metal ion binding;protein binding	Pf01186	4015	ENSG00000113083.13	LOX	5	Elastic fibre formation; Crosslinking of collagen fibrils		0
Medium	Q8N584	Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=2 SV=2	0.036	1.268	1	1	3	1	583	65.8	6.99		1	1	1		1	1	1	4605116.5	2996108	3586563.25	4441924	1	1	1	1				protein binding	Pf10300	125488	ENSG00000168234.12	TTC39C	18			0
High	P04181	"Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1"	0.003	2.508	2	1	3	1	439	48.5	7.03	1		1		2		1		323809.6563	396512.25	533361	975432.3125	1	1	1	1		cell organization and biogenesis;metabolic process	cytoplasm;mitochondrion;organelle lumen	catalytic activity;protein binding	Pf00202	4942	ENSG00000065154.11	OAT	10	Amino acid synthesis and interconversion (transamination)	Metabolic pathways; Arginine and proline metabolism	0
High	Q5C9Z4	Nucleolar MIF4G domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOM1 PE=1 SV=1	0	3.691	2	1	3	1	860	96.2	8.1		1	1	1		1	1	1	84040.71875	166966.9063	286772.9063	301313.5625	1	1	1	1		cell differentiation	nucleus	protein binding;RNA binding	"Pf02847, Pf02854"	64434	ENSG00000146909.7	NOM1	7			0
High	O43303	Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3	0	4.737	3	2	3	2	1012	113.4	8.65		2	1			2	1		345311.9609	1600747.875	978688.5625	461199.6563	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytoskeleton;cytosol	protein binding		9738	ENSG00000103540.16	CCP110	16	Ub-specific processing proteases; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes		0
High	P62304	Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1	0.001	3.159	12	1	3	1	92	10.8	9.44	1	1		1	1	1		1	765235.0625	561014	802490.9375	936963.8125	1	1	1	1		cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf01423	6635	ENSG00000182004.12	SNRPE	1	SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region	Spliceosome	0
Medium	Q9Y3D3	"28S ribosomal protein S16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1"	0.03	1.35	6	1	3	1	137	15.3	9.5		1	1	1		1	1	1		464642.7188	672848.75	807617.3125		1	1	1		cell organization and biogenesis;metabolic process	cytosol;membrane;mitochondrion;ribosome	protein binding;structural molecule activity	Pf00886	51021	ENSG00000182180.13	MRPS16	10	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination	Ribosome	0
High	Q9Y2X3	Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1	0	5.161	5	2	3	2	529	59.5	8.92	1	1		1	1	1		1	208191.7969	338945.3438	409981.8594	431035.7344	1	2	2	2		cell growth;metabolic process	cytosol;membrane;nucleus	protein binding;RNA binding	"Pf01798, Pf08060, Pf08156"	51602	ENSG00000055044.10	NOP58	2	Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SUMOylation of RNA binding proteins	Ribosome biogenesis in eukaryotes	0
High	Q9UJS0	Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens OX=9606 GN=SLC25A13 PE=1 SV=2	0.002	2.609	3	2	3	2	675	74.1	8.62			1	2			1	2			151233.3438	441063.4688			1	1		metabolic process;response to stimulus;transport	membrane;mitochondrion	metal ion binding;transporter activity	"Pf00153, Pf13499"	10165	ENSG00000004864.13	SLC25A13	7	Gluconeogenesis; Mitochondrial protein import; Metabolism of proteins		0
Medium	P49792	E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2	0.033	1.299	1	1	3	1	3224	358	6.2	1		1	1	1		1	1	710213.125	176682.4219	292793.7813	341058.3438	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;enzyme regulator activity;metal ion binding;protein binding;RNA binding	"Pf00160, Pf00515, Pf00638, Pf00641, Pf07719, Pf12185, Pf13414, Pf13432, Pf14559"	5903	ENSG00000153201.15	RANBP2	2	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	Q53H12	"Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2"	0.001	3.091	5	2	3	2	422	47.1	8.09			1	2			1	2	50594.76953	82810.83594	378592.5156	398385.3438	1	1	2	2		cell organization and biogenesis;metabolic process;transport	cytosol;membrane;mitochondrion	catalytic activity;nucleotide binding	Pf00781	55750	ENSG00000006530.15	AGK	7	Signaling by BRAF and RAF fusions; Glycerophospholipid biosynthesis	Glycerolipid metabolism; Metabolic pathways	0
High	Q96KQ4	Apoptosis-stimulating of p53 protein 1 OS=Homo sapiens OX=9606 GN=PPP1R13B PE=1 SV=3	0	4.153	2	2	3	2	1090	119.5	6.76			1	2			1	2		328441.7031	559594.1406	660259.75		2	2	2		cell death;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;mitochondrion;nucleus	protein binding	"Pf00018, Pf00023, Pf07653, Pf10498, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604"	23368	ENSG00000088808.16	PPP1R13B	14	Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation of PUMA and translocation to mitochondria		0
High	Q9Y3C7	Mediator of RNA polymerase II transcription subunit 31 OS=Homo sapiens OX=9606 GN=MED31 PE=1 SV=1	0.004	2.219	5	1	3	1	131	15.8	8.54		1	1	1		1	1	1	109582.7344	190276.8906	302321.0313	350319.0625	1	1	1	1		metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding	Pf05669	51003	ENSG00000108590.10	MED31	17	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway		0
Medium	P56545	C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1	0.03	1.343	2	1	3	1	445	48.9	6.95			1	1			1	2			5402675	33231980			1	1		cell differentiation;metabolic process;regulation of biological process	cytosol;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00389, Pf02826"	1488	ENSG00000175029.16	CTBP2	10	Repression of WNT target genes; TCF7L2 mutants don't bind CTBP	Chronic myeloid leukemia; Pathways in cancer; Wnt signaling pathway; Notch signaling pathway	0
High	Q9H3K6	BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2 PE=1 SV=1	0	3.921	19	1	3	1	86	10.1	6.52	1	1	1		1	1	1		426154.875	554254.1875	442272.9375	642658.125	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	protein binding	Pf01722	654483; 552900; 107984053		BOLA2B; BOLA2; LOC107984053	16	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling		0
Medium	Q504Q3	PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Homo sapiens OX=9606 GN=PAN2 PE=1 SV=3	0.044	1.144	0	1	3	1	1202	135.3	5.99		1	1	1		1	1	1		293626.8125	456985.8438	1387649.125		1	1	1		metabolic process	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00443, Pf00929, Pf13423"	9924	ENSG00000135473.14	PAN2	12	Deadenylation of mRNA	RNA degradation	0
Low	Q9UKN7	Unconventional myosin-XV OS=Homo sapiens OX=9606 GN=MYO15A PE=1 SV=2	0.056	1.041	0	1	3	1	3530	395	9.17		1		1		1		2	5381927	7799353	8651635	8449323	1	1	1	1		response to stimulus	cytoplasm;cytoskeleton	catalytic activity;motor activity;nucleotide binding;protein binding	"Pf00063, Pf00373, Pf00784, Pf07653, Pf15279"	51168	ENSG00000091536.16	MYO15A	17			0
Medium	P0DPK5	Histone H3.X OS=Homo sapiens OX=9606 GN=H3Y2 PE=5 SV=1	0.043	1.148	5	1	3	1	147	16.5	11.39		1	1	1		1	1	1	1536857.375	5241811.5	4349163	2501326.75	1	1	1	1												0
High	P24941	Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2	0	4.307	6	2	3	1	298	33.9	8.68	1		1		2		1		1052568.875	1084912.438	1306399.906	1139582.75	1	2	2	1		cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytoskeleton;cytosol;endosome;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00069, Pf07714, Pf14531"	1017	ENSG00000123374.10	CDK2	12	p53-Dependent G1 DNA Damage Response; G0 and Early G1; Regulation of DNA replication; Activation of the pre-replicative complex; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; Factors involved in megakaryocyte development and platelet production; G2 Phase; Meiotic recombination; Regulation of APC/C activators between G1/S and early anaphase; PTK6 Regulates Cell Cycle; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Degradation; CDK-mediated phosphorylation and removal of Cdc6; Orc1 removal from chromatin; Cyclin A/B1/B2 associated events during G2/M transition; M/G1 Transition; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Removal of licensing factors from origins	Viral carcinogenesis; Hepatitis B; FoxO signaling pathway; Epstein-Barr virus infection; Progesterone-mediated oocyte maturation; Pathways in cancer; Prostate cancer; p53 signaling pathway; Oocyte meiosis; Measles; Small cell lung cancer; Herpes simplex infection; Cell cycle; PI3K-Akt signaling pathway	1
High	P82650	"28S ribosomal protein S22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1"	0.005	2.049	3	1	3	1	360	41.3	7.9	1		1	1	1		1	1	217403.9375	243998.8906	364709.6875	393383.1875	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	structural molecule activity	Pf10245	56945	ENSG00000175110.11	MRPS22	3	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination		0
High	P56192	"Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2"	0	4.002	2	2	3	2	900	101.1	6.16		1	1	1		1	1	1	381538.25	554372.4844	567585.7969	1013789.219	2	2	2	2		cell communication;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00043, Pf00133, Pf00458, Pf09334, Pf10978, Pf13409, Pf13410, Pf14497"	4141	ENSG00000166986.14	MARS	12	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Selenocompound metabolism; Aminoacyl-tRNA biosynthesis	0
High	P09661	U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2	0.002	2.682	4	1	3	1	255	28.4	8.62	1	1	1		1	1	1		248045.3906	345891.4688	417000.6875	401680.6875	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf12799, Pf13855, Pf14580"	6627	ENSG00000131876.16	SNRPA1	15	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway	Spliceosome	0
High	Q6NUS6	Tectonic-3 OS=Homo sapiens OX=9606 GN=TCTN3 PE=1 SV=2	0	5.852	5	3	3	3	607	66.1	8.21				3				3	39151.94531	132284.7969	104464.7188	642301.875	1	1	1	1		cell death;cell organization and biogenesis;regulation of biological process;response to stimulus	membrane;nucleus		Pf07773	26123	ENSG00000119977.20	TCTN3	10	Anchoring of the basal body to the plasma membrane		0
Medium	Q99848	Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2	0.012	1.719	3	1	3	1	306	34.8	10.1		1	1	1		1	1	1	145220.9688	86550.14063	176497.9063	196728.9219	1	1	1	1		metabolic process	nucleus	protein binding;RNA binding	Pf05890	10969	ENSG00000117395.12	EBNA1BP2	1	Major pathway of rRNA processing in the nucleolus and cytosol		0
High	P06733	Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2	0.001	2.863	6	2	3	2	434	47.1	7.39		1		1		1		2	418388.5938	587554.6875	304120.0391	706304.9531	2	2	2	2		metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;cytosol;membrane;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	"Pf00113, Pf03952, Pf13378"	2023	ENSG00000074800.13	ENO1	1	Gluconeogenesis; Glycolysis	HIF-1 signaling pathway; Carbon metabolism; Glycolysis / Gluconeogenesis; RNA degradation; Biosynthesis of amino acids; Metabolic pathways	0
High	P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1	0	4.697	6	2	3	2	309	35.6	5.43		2	1			2	1			988112.3125	1406653.063	2011595.313		2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	Pf00149	5516	ENSG00000104695.12	PPP2CB	8	"Glycolysis; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; S33 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex"	Dopaminergic synapse; Chagas disease (American trypanosomiasis); TGF-beta signaling pathway; Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; Long-term depression; mRNA surveillance pathway; Oocyte meiosis; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway	0
High	P05166	"Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3"	0	6.047	6	2	3	2	539	58.2	7.64			2	1			2	1		238682.6875	639016.5625	399377.2813		1	2	1		metabolic process	cytosol;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding	Pf01039	5096	ENSG00000114054.13	PCCB	3	Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism	"Propanoate metabolism; Carbon metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Valine, leucine and isoleucine degradation"	0
High	Q15393	Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4	0	5.878	3	3	3	3	1217	135.5	5.26	2			1	2			1	494124.1406	579362.4844	689033.7188	708749.5938	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf03178, Pf10433"	23450	ENSG00000189091.12	SF3B3	16	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	P32121	Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2	0.007	1.92	2	1	3	1	409	46.1	7.69		1	1	1		1	1	1		239749.9375	333772.3125	253140.8281		1	1	1		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus	protein binding;structural molecule activity	"Pf00339, Pf02752"	409	ENSG00000141480.17	ARRB2	17	Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; G alpha (s) signalling events; Signaling by BRAF and RAF fusions; Ub-specific processing proteases; MAP2K and MAPK activation; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Thrombin signalling through proteinase activated receptors (PARs); Paradoxical activation of RAF signaling by kinase inactive BRAF; Activation of SMO; Interleukin-20 family signaling; WNT5A-dependent internalization of FZD4	Dopaminergic synapse; Endocytosis; MAPK signaling pathway; Olfactory transduction; Morphine addiction; Hedgehog signaling pathway; Chemokine signaling pathway	0
High	Q02809	"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2"	0	6.91	5	3	3	3	727	83.5	6.95				3				3	746720.625	851306.4375	1486587	2026787.031	1	1	1	2		metabolic process;response to stimulus	endoplasmic reticulum;membrane	catalytic activity;metal ion binding;protein binding	Pf03171	5351	ENSG00000083444.16	PLOD1	1	Collagen biosynthesis and modifying enzymes	Lysine degradation	0
High	Q4VCS5	Angiomotin OS=Homo sapiens OX=9606 GN=AMOT PE=1 SV=1	0	5.904	3	3	3	3	1084	118	7.64	3				3				695922.4063		540219.4688	440182.7656	2		2	2		cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cell surface;cytoplasm;cytosol	protein binding;receptor activity	Pf12240	154796	ENSG00000126016.15	AMOT	X	Signaling by Hippo	Hippo signaling pathway	0
High	P48643	T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1	0	4.147	7	2	3	2	541	59.6	5.66	1		1	1	1		1	1	208505.2031	257220.0781	327156.1875	682042.3594	1	1	1	2		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol	nucleotide binding;protein binding;RNA binding	Pf00118	22948	ENSG00000150753.11	CCT5	5	BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC		0
High	P02786	Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2	0	8.55	6	3	3	3	760	84.8	6.61				3				3	122651.7578			1325991.563	1			2		cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endosome;extracellular;membrane	protein binding;receptor activity;RNA binding;transporter activity	"Pf02225, Pf04253, Pf04389"	7037	ENSG00000072274.12	TFRC	3	Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; Golgi Associated Vesicle Biogenesis	Endocytosis; HIF-1 signaling pathway; Hematopoietic cell lineage; Phagosome	0
High	Q8IUD2	ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1	0	4.945	3	3	3	3	1116	128	5.97		3				3			437278.4688	1097566.813	206929.957	114496.8984	3	3	2	1		development;metabolic process;regulation of biological process;transport	cytoplasm;endoplasmic reticulum;Golgi;membrane	protein binding;transporter activity	"Pf01496, Pf04156, Pf05529, Pf05557, Pf05622, Pf07888, Pf09457, Pf09726, Pf10174, Pf10186, Pf12128, Pf13166"	23085	ENSG00000283017.1; ENSG00000082805.19	ERC1	12; CHR_HSCHR12_2_CTG1		NF-kappa B signaling pathway	0
High	Q16576	Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1	0.003	2.501	2	1	3	1	425	47.8	5.05		1	1	1		1	1	1	173880.0938	195822.2969	331479.2813	304254.3125	1	1	1	1		cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;protein binding;RNA binding	"Pf00400, Pf12265"	5931	ENSG00000102054.17	RBBP7	X	RMTs methylate histone arginines; Regulation of TP53 Activity through Acetylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HATs acetylate histones; Neddylation; Deposition of new CENPA-containing nucleosomes at the centromere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; HDACs deacetylate histones; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation		0
High	O15460	Prolyl 4-hydroxylase subunit alpha-2 OS=Homo sapiens OX=9606 GN=P4HA2 PE=1 SV=1	0	4.727	5	3	3	3	535	60.9	5.71			1	2			1	2	198683.2031	527843.4063	626977.375	1473978.281	1	2	2	3		metabolic process	cytosol;endoplasmic reticulum;organelle lumen	catalytic activity;metal ion binding;protein binding	"Pf03171, Pf08336, Pf13640"	8974	ENSG00000072682.18	P4HA2	5	Collagen biosynthesis and modifying enzymes	Metabolic pathways; Arginine and proline metabolism	0
High	Q9NZI7	Upstream-binding protein 1 OS=Homo sapiens OX=9606 GN=UBP1 PE=1 SV=1	0.001	2.938	3	2	3	2	540	60.5	6.35		1	2			1	2		436867.8125	389938	597459.9531	484866.4063	1	1	2	1		metabolic process;regulation of biological process	cytosol;nucleus	DNA binding	Pf04516	7342	ENSG00000153560.11	UBP1	3			0
High	Q9NWH9	SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2	0	4.576	4	2	3	2	1034	117.1	7.87	1			2	1			2	1967933.25	1955711.75	1577618.375	3496005.75	1	1	1	1	Met-loss+Acetyl [N-Term]	cell death;metabolic process;regulation of biological process	nucleus	DNA binding;RNA binding	"Pf00076, Pf02037, Pf13893, Pf14259"	79811	ENSG00000137776.16	SLTM	15			0
High	Q9BZQ6	ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2	0	5.954	4	3	3	3	932	104.6	4.93			2	1			2	1			1805097.188	757173.3438			2	2		metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;membrane;organelle lumen	catalytic activity;metal ion binding	"Pf01532, Pf02225"	80267	ENSG00000116406.18	EDEM3	1	ER Quality Control Compartment (ERQC)	Protein processing in endoplasmic reticulum	0
High	P25440	Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2	0	4.7	3	2	3	2	801	88	9.09	1	1	1		1	1	1		230637.4531	394645.5313	123591.6328	870971.0156	1	1	1	2		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;nucleus	protein binding	Pf00439	6046	ENSG00000204256.12; ENSG00000235307.9; ENSG00000234507.9; ENSG00000215077.10	BRD2	6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1	RUNX3 regulates p14-ARF		0
High	Q8IZ83	Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2	0	3.9	4	2	3	2	802	85.1	6.79	2				3				944103.875	138058.9844	61441.69141		2	2	1			metabolic process	membrane	catalytic activity	"Pf00171, Pf07368"	126133	ENSG00000161618.9	ALDH16A1	19			0
High	P35659	Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1	0.005	2.075	2	1	3	1	375	42.6	8.56	1		1	1	1		1	1	350470.4688	318922.9375	450082.875	357928.6563	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	DNA binding;protein binding;RNA binding	"Pf02037, Pf08766"	7913	ENSG00000124795.14	DEK	6	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; B-WICH complex positively regulates rRNA expression		0
High	Q9UQE7	Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2	0	7.004	3	3	3	3	1217	141.5	7.18				3				3	302175.2656	65787.57031	403717.4063	1011496.563	3	1	3	3		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytosol;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity	"Pf01496, Pf02463, Pf04111, Pf06470, Pf10168, Pf12128, Pf13304, Pf13476, Pf13555"	9126	ENSG00000108055.9	SMC3	10	Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins	Oocyte meiosis; Cell cycle	0
High	Q14247	Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2	0	5.214	6	3	3	3	550	61.5	5.4	2	1			2	1			638618.9063	603986.25	869788.9063	705494.9688	3	2	3	3		cell organization and biogenesis;cellular component movement;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;Golgi;membrane	protein binding	"Pf00018, Pf02218, Pf07653, Pf14604"	2017	ENSG00000085733.15	CTTN	11	RHO GTPases activate PAKs; Clathrin-mediated endocytosis	Tight junction; Pathogenic Escherichia coli infection; Proteoglycans in cancer; Bacterial invasion of epithelial cells; Shigellosis	0
High	Q99459	Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2	0	5.102	5	3	3	3	802	92.2	8.18	1	1		1	1	1		1	816097.7344	867003.4531	1206649.188	1650956.188	3	3	3	3		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus;spliceosomal complex	DNA binding;protein binding;RNA binding	"Pf00249, Pf11831, Pf13921"	988	ENSG00000096401.7	CDC5L	6	mRNA Splicing - Major Pathway	Spliceosome	0
High	P08559	"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3"	0	4.003	5	2	3	2	390	43.3	8.06			1	2			1	2	178036.4688	282908.5313	675983.9375	772287.2188	1	2	2	2		metabolic process;regulation of biological process	mitochondrion;nucleus;organelle lumen	catalytic activity;protein binding	Pf00676	5160	ENSG00000131828.13	PDHA1	X	Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation	Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways	0
High	O14818	Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1	0	5.355	14	3	3	3	248	27.9	8.46				3				3		812868.4688	1584339.578	8511240.156		2	3	3		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding	"Pf00227, Pf10584"	5688	ENSG00000101182.14	PSMA7	20	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	Q9H936	Mitochondrial glutamate carrier 1 OS=Homo sapiens OX=9606 GN=SLC25A22 PE=1 SV=1	0	4.157	8	3	3	3	323	34.4	9.29			1	2			1	2	25607.92773		596200.7344	1973332.656	1		3	3		transport	membrane;mitochondrion	transporter activity	Pf00153	79751	ENSG00000177542.10	SLC25A22	11	Organic anion transporters		0
High	Q6P2C8	Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1	0	5.834	8	3	3	3	311	35.4	9.31		1	1	1		1	1	1	302921.0234	353272.6875	612151.0781	393898.0938	2	2	3	1		metabolic process;regulation of biological process	cytosol;nucleus	catalytic activity;protein binding	Pf11571	9442	ENSG00000160563.13	MED27	9	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
High	P42285	Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3	0	4.04	2	2	3	2	1042	117.7	6.52	1		1	1	1		1	1	166072.4531	220472.7813	245565.3594	173485.9531	1	1	1	1		metabolic process	nucleus;spliceosomal complex	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf04851, Pf08148, Pf13234"	23517	ENSG00000039123.15	SKIV2L2	5	Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway	RNA degradation	0
High	O75533	Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3	0.001	3.296	1	1	3	1	1304	145.7	7.09		1	1	1		1	1	1	234088.0625	222121.8438	278505.25	285892.6563	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus;spliceosomal complex	DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity	"Pf02161, Pf08920, Pf12815, Pf13513"	23451	ENSG00000115524.15	SF3B1	2	B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
High	Q96S52	GPI transamidase component PIG-S OS=Homo sapiens OX=9606 GN=PIGS PE=1 SV=3	0.004	2.106	1	1	3	1	555	61.6	6.49			1	1			2	1			405888.2813	318696.875			1	1		metabolic process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf10510	94005	ENSG00000087111.20	PIGS	17	Attachment of GPI anchor to uPAR	Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0
High	Q96K37	Solute carrier family 35 member E1 OS=Homo sapiens OX=9606 GN=SLC35E1 PE=1 SV=2	0	4.76	10	2	3	2	410	44.7	9.79		1	1	1		1	1	1	19858.39648	2487097.656	313329.4375	709872.125	1	2	1	1	Met-loss+Acetyl [N-Term]	transport	Golgi;membrane		"Pf03151, Pf08449"	79939	ENSG00000127526.14	SLC35E1	19			0
Medium	Q86XM0	Cation channel sperm-associated protein subunit delta OS=Homo sapiens OX=9606 GN=CATSPERD PE=1 SV=3	0.042	1.167	2	1	3	1	798	90.4	7.37	1	1	1		1	1	1		15189960	15199936	14047303	17138912	1	1	1	1		cell differentiation;cellular component movement;development;response to stimulus	membrane	protein binding	Pf15020	257062	ENSG00000174898.15	CATSPERD	19	Sperm Motility And Taxes		0
High	Q9UPS8	Ankyrin repeat domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ANKRD26 PE=1 SV=4	0	4.213	1	2	3	2	1710	196.3	5.72			2	1			2	1		300952.2891	592627.875	591772.8438		2	2	2												0
High	O43837	"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2"	0.001	2.889	5	2	3	2	385	42.2	8.46	1			2	1			2	432599.5	445259.5625	303299.625	607186.0156	2	2	2	2		metabolic process	mitochondrion;nucleus;organelle lumen	catalytic activity;metal ion binding;nucleotide binding	Pf00180	3420	ENSG00000101365.20	IDH3B	20	Citric acid cycle (TCA cycle)	Citrate cycle (TCA cycle); Carbon metabolism; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Metabolic pathways	0
High	P35232	Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1	0	5.808	9	2	3	2	272	29.8	5.76		1	1	1		1	1	1	253835.7188	580978.5625	530384.125	924130.8125	1	1	1	1		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus	DNA binding;protein binding	Pf01145	5245	ENSG00000167085.11	PHB	17	Paradoxical activation of RAF signaling by kinase inactive BRAF; Processing of SMDT1; RAF activation; Signaling by RAS mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling		0
High	P22234	Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3	0	8.977	10	3	3	3	425	47	7.23			2	1			2	1	884831.0625	598719.7188	1061623.734	822894.7031	3	3	3	3	Met-loss+Acetyl [N-Term]	metabolic process	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding	"Pf00731, Pf01259"	10606	ENSG00000128050.8	PAICS	4	Purine ribonucleoside monophosphate biosynthesis	Purine metabolism; Metabolic pathways	0
High	Q08945	FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1	0	4.975	4	3	3	3	709	81	6.87		3				3			66387.10742	561510.0938	306799.5703	279428.4766	2	3	3	3		metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	DNA binding;protein binding;RNA binding	"Pf00505, Pf03531, Pf08512, Pf09011"	6749	ENSG00000149136.8	SSRP1	11	HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat		0
High	Q8WUY1	Protein THEM6 OS=Homo sapiens OX=9606 GN=THEM6 PE=1 SV=2	0.001	3.092	4	1	3	1	208	23.9	9.55		1	1	1		1	1	1		638727.625	352204.3438	559633.0625		1	1	1			extracellular		Pf13279	51337	ENSG00000130193.7	THEM6	8			0
High	Q96AY3	Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Homo sapiens OX=9606 GN=FKBP10 PE=1 SV=1	0	5.347	5	3	3	3	582	64.2	5.62				3				3			346644.6406	1188832.297			2	3		cell organization and biogenesis;metabolic process	cytoplasm;endoplasmic reticulum;organelle lumen	catalytic activity;metal ion binding	Pf00254	60681	ENSG00000141756.18	FKBP10	17			0
High	Q5D862	Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1	0.005	2.001	0	1	3	1	2391	247.9	8.31	1	1		1	1	1		1	408678.5	409265.9688	347470.3438	404076.0625	1	1	1	1		transport	cytoplasm;extracellular;nucleus	metal ion binding;structural molecule activity		388698	ENSG00000143520.6	FLG2	1	Neutrophil degranulation		0
High	Q8TDY2	RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3	0.004	2.359	1	1	3	1	1594	183	5.41			1	1			2	1		159670.3438	1128691.875	499651.375		1	1	1		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	protein binding;structural molecule activity	"Pf03938, Pf04111, Pf05667, Pf10377, Pf12128"	9821	ENSG00000023287.12	RB1CC1	8	Macroautophagy	Longevity regulating pathway	0
High	Q6P3S6	F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1	0.001	3.224	1	1	3	1	717	77.8	7.43		1	1	1		1	1	1		300396.7188	383740.5313	389307.3125		1	1	1				protein binding	"Pf00646, Pf01344, Pf07646, Pf12937, Pf13415, Pf13418, Pf13854, Pf13964"	54455	ENSG00000037637.10	FBXO42	1			0
High	P60228	Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1	0	4.873	7	2	3	2	445	52.2	6.04	1	2			1	2			272849.4688	1031308.875	694170.4688	528259.5625	2	2	2	2		metabolic process;regulation of biological process	chromosome;cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	"Pf01399, Pf09440"	3646	ENSG00000104408.9	EIF3E	8	"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition"	RNA transport; Hepatitis C	0
High	A5YKK6	CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2	0	5.598	1	3	3	3	2376	266.8	7.11	3				3				492317.2266	30908.96289	37871.00391	49465.04688	3	1	1	1		development;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;protein binding;RNA binding;structural molecule activity	"Pf04054, Pf12842"	23019	ENSG00000125107.17	CNOT1	16	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA	RNA degradation	0
High	Q9BX67	Junctional adhesion molecule C OS=Homo sapiens OX=9606 GN=JAM3 PE=1 SV=1	0	4.169	8	2	3	2	310	35	7.59			2				3				977639.5625	182764.6094			1	1		cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	"Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927"	83700	ENSG00000166086.12	JAM3	11	Integrin cell surface interactions; Cell surface interactions at the vascular wall	Tight junction; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection	0
High	P28066	Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3	0	5.61	8	1	3	1	241	26.4	4.79		1	1	1		1	1	1	80868.89063	485791.125	544917.5625	931963.75	1	1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome	catalytic activity;nucleotide binding;protein binding	"Pf00227, Pf10584"	5686	ENSG00000143106.12	PSMA5	1	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	Q9BWS9	Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1	0	4.72	8	3	3	3	393	44.9	8.63				3				3			154464.4063	1515461			1	2		defense response;metabolic process;regulation of biological process;response to stimulus;transport	endosome;extracellular;membrane;nucleus;organelle lumen;vacuole	catalytic activity;protein binding	Pf00704	66005	ENSG00000177830.17	CHID1	11	Platelet degranulation		0
High	P09234	U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1	0	4.813	11	1	3	1	159	17.4	9.67	1	1		1	1	1		1	787097.5	1114274.5	1350696.25	1579724.625	1	1	1	1		cell organization and biogenesis;metabolic process	nucleus;spliceosomal complex	metal ion binding;protein binding;RNA binding	Pf06220	6631	ENSG00000124562.9	SNRPC	6	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q96EP5	DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1	0.003	2.568	4	1	3	1	407	43.4	8.56	1		1	1	1		1	1	425715.4688	440744.2188	650168.0625	1000484.063	1	1	1	1		cell differentiation;cell proliferation;development;regulation of biological process	cytoplasm;cytosol;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	26528	ENSG00000071626.16	DAZAP1	19		mRNA surveillance pathway	0
High	Q9Y4I1	Unconventional myosin-Va OS=Homo sapiens OX=9606 GN=MYO5A PE=1 SV=2	0.001	2.695	1	1	3	1	1855	215.3	8.48	1	1		1	1	1		1	337907.5	259574.9688	262931.5313		1	1	1			cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;vacuole	catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;RNA binding	"Pf00063, Pf00612, Pf00769, Pf01442, Pf01576, Pf01843, Pf02463, Pf04111, Pf04156, Pf05262, Pf05557, Pf06160, Pf07888, Pf07926, Pf09726, Pf09731, Pf10174, Pf12128, Pf12718, Pf13851, Pf14992, Pf15035, Pf15070"	4644	ENSG00000197535.14	MYO5A	15	Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation; Insulin processing		0
High	P36957	"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4"	0	3.612	4	2	2	2	453	48.7	8.95	2				2				519529.7188				1					metabolic process	membrane;mitochondrion;nucleus;organelle lumen	catalytic activity	"Pf00198, Pf00364"	1743	ENSG00000119689.14	DLST	14	Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)	Citrate cycle (TCA cycle); Carbon metabolism; Lysine degradation; Metabolic pathways	0
High	Q3SY77	UDP-glucuronosyltransferase 3A2 OS=Homo sapiens OX=9606 GN=UGT3A2 PE=2 SV=1	0	8.817	5	2	2	2	523	59.5	8.31				2				2				791033.5				1		metabolic process;response to stimulus	membrane	catalytic activity	Pf00201	167127	ENSG00000168671.9	UGT3A2	5	Glucuronidation		0
High	Q13242	Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1	0.005	2.06	10	2	2	2	221	25.5	8.65		1		1		1		1	260521.5078	352431.3906	295445.8281	84349.03906	2	2	2	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	8683	ENSG00000111786.8	SRSF9	12	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway	Spliceosome; Herpes simplex infection	0
High	Q86Y07	Serine/threonine-protein kinase VRK2 OS=Homo sapiens OX=9606 GN=VRK2 PE=1 SV=3	0.004	2.095	2	1	2	1	508	58.1	8.84		1	1			1	1			177302.3594	212014.9063	133902.8438		1	1	1		metabolic process;regulation of biological process;response to stimulus	cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf07714"	7444	ENSG00000028116.16	VRK2	2			0
High	P47897	Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1	0.004	2.345	1	1	2	1	775	87.7	7.15	1			1	1			1	209537.5313	215444.1719	236472.7656	218982.6719	1	1	1	1		metabolic process;regulation of biological process	cytoplasm;cytosol;organelle lumen	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00749, Pf03950, Pf04557, Pf04558"	5859	ENSG00000172053.17	QARS	3	Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins	Aminoacyl-tRNA biosynthesis; Metabolic pathways	0
Medium	A8MTJ3	Guanine nucleotide-binding protein G(t) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAT3 PE=2 SV=2	0.031	1.332	3	1	2	1	354	40.3	6.01			1	1			1	1		482710.5	499733.5625	646942.375		1	1	1		metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane	catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity	"Pf00025, Pf00503"	346562	ENSG00000214415.3	GNAT3	7	"G alpha (z) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; PLC beta mediated events; ADP signalling through P2Y purinoceptor 12; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Adenylate cyclase inhibitory pathway; G-protein activation"	Taste transduction; Carbohydrate digestion and absorption	0
High	Q12800	Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2	0	6.743	6	2	2	2	502	57.2	5.8			2				2			805040.8438	1468756.156			2	2			metabolic process;regulation of biological process	cytosol;nucleus	DNA binding;protein binding	Pf04516	7024	ENSG00000135457.9	TFCP2	12			0
High	Q9H8E8	Cysteine-rich protein 2-binding protein OS=Homo sapiens OX=9606 GN=KAT14 PE=1 SV=3	0	3.552	3	2	2	2	782	88.8	6.57			2				2		41473.25781	610703.8125	810695.7188	249842.0781	1	2	2	1		cell organization and biogenesis;metabolic process	cytoplasm;mitochondrion;nucleus	catalytic activity;protein binding	"Pf00583, Pf08445, Pf13508, Pf13527, Pf13673"	100303755; 57325	ENSG00000149474.13	PET117; CSRP2BP; KAT14	20	HATs acetylate histones		0
High	Q9NQX3	Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1	0	4.867	3	2	2	2	736	79.7	5.43	1		1		1		1		669562.625	409598.4531	202143.0938		2	2	1		Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;response to stimulus	cytoplasm;cytoskeleton;membrane	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00994, Pf03453, Pf03454"	10243	ENSG00000171723.15	GPHN	14	Molybdenum cofactor biosynthesis	Folate biosynthesis; GABAergic synapse; Metabolic pathways	0
High	Q14573	"Inositol 1,4,5-trisphosphate receptor type 3 OS=Homo sapiens OX=9606 GN=ITPR3 PE=1 SV=2"	0.005	2.064	0	1	2	1	2671	303.9	6.48	1		1		1		1		135047.0938	246670.0156	214628.4219	109143.9375	1	1	1	1		cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;membrane;nucleus	metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity	"Pf00520, Pf01027, Pf01365, Pf02815, Pf03772, Pf08454, Pf08709"	3710	ENSG00000096433.10	ITPR3	6	Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis	Dopaminergic synapse; Serotonergic synapse; NOD-like receptor signaling pathway; Vascular smooth muscle contraction; Glutamatergic synapse; cGMP-PKG signaling pathway; Renin secretion; Oxytocin signaling pathway; Circadian entrainment; Long-term potentiation; Insulin secretion; Gap junction; Phosphatidylinositol signaling system; Taste transduction; Glucagon signaling pathway; Thyroid hormone synthesis; Pancreatic secretion; Apoptosis; Proteoglycans in cancer; Alzheimer's disease; Long-term depression; Aldosterone synthesis and secretion; Retrograde endocannabinoid signaling; Oocyte meiosis; Gastric acid secretion; Salivary secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Estrogen signaling pathway; Cholinergic synapse; Calcium signaling pathway; Platelet activation	0
High	Q07955	Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2	0	3.827	5	1	2	1	248	27.7	10.36		1	1			1	1		446423.4375	548488.5625	580166.5625	521170.5313	1	1	1	1		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	6426	ENSG00000136450.12	SRSF1	17	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome; Herpes simplex infection	0
High	Q13405	"39S ribosomal protein L49, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1"	0	3.595	7	1	2	1	166	19.2	9.45			1	1			1	1	240923.8594	314735.3438	426860.5625	343092.8125	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	protein binding;structural molecule activity	Pf05046	740	ENSG00000149792.8	MRPL49	11	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination		0
High	Q9Y4P1	Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2	0.003	2.432	3	1	2	1	393	44.3	5.07		1	1			1	1		177694.6719	162127.3594			1	1			Acetyl [N-Term]	cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol	catalytic activity;protein binding	Pf03416	23192	ENSG00000168397.16	ATG4B	2	Macroautophagy	Autophagy	0
Medium	Q9NV96	Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1	0.017	1.617	3	1	2	1	361	40.7	8.59			1	1			1	1			356287.0938	727275.5625			1	1		cell organization and biogenesis;regulation of biological process;transport	endoplasmic reticulum;Golgi;membrane	protein binding;transporter activity	Pf03381	55754	ENSG00000112697.15	TMEM30A	6	Neutrophil degranulation		0
High	P06756	Integrin alpha-V OS=Homo sapiens OX=9606 GN=ITGAV PE=1 SV=2	0	4.306	2	2	2	2	1048	116	5.68				2				2				692126.2188				2		cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytosol;membrane	metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity	"Pf01839, Pf08441, Pf13517"	3685	ENSG00000138448.11	ITGAV	2	Integrin cell surface interactions; Signal transduction by L1; PECAM1 interactions; Cross-presentation of particulate exogenous antigens (phagosomes); VEGFA-VEGFR2 Pathway; Molecules associated with elastic fibres; Syndecan interactions; ECM proteoglycans; Laminin interactions; Neutrophil degranulation	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Cell adhesion molecules (CAMs); Pathways in cancer; Thyroid hormone signaling pathway; Phagosome; Focal adhesion; Proteoglycans in cancer; Regulation of actin cytoskeleton; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Hypertrophic cardiomyopathy (HCM)	0
High	Q9Y3F4	Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1	0.001	2.787	9	2	2	2	350	38.4	5.12			1	1			1	1	344539.8438	248733.0313	332662.9063	292993.7188	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;nucleus	protein binding;RNA binding	Pf00400	11171	ENSG00000023734.10	STRAP	12	Downregulation of TGF-beta receptor signaling	RNA transport	0
High	P05455	Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2	0	5.262	6	2	2	2	408	46.8	7.12		1	1			1	1			392793.125		360704.0938		1		1		metabolic process;transport	cytoplasm;nucleus	protein binding;RNA binding	"Pf00076, Pf05383, Pf08777, Pf14259"	6741	ENSG00000138385.15	SSB	2	RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination	Systemic lupus erythematosus	0
High	P54709	Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1	0.001	2.927	6	2	2	2	279	31.5	8.35				2				2			117067.8203	456416.125			1	1		cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;transport	cytoplasm;membrane	catalytic activity;enzyme regulator activity;protein binding;transporter activity	Pf00287	483	ENSG00000069849.10	ATP1B3	3	Ion homeostasis; Basigin interactions; Ion transport by P-type ATPases	Bile secretion; cGMP-PKG signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Protein digestion and absorption; Proximal tubule bicarbonate reclamation; Thyroid hormone signaling pathway; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Pancreatic secretion; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Gastric acid secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Mineral absorption	0
High	Q96A33	Coiled-coil domain-containing protein 47 OS=Homo sapiens OX=9606 GN=CCDC47 PE=1 SV=1	0.001	3.232	6	2	2	2	483	55.8	4.87				2				2	56818.28125	43487.07422	358274.4688	769547.2031	1	1	2	2		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;membrane	metal ion binding;protein binding;RNA binding	Pf07946	57003	ENSG00000108588.13	CCDC47	17			0
High	Q9Y679	Ancient ubiquitous protein 1 OS=Homo sapiens OX=9606 GN=AUP1 PE=1 SV=2	0	7.348	7	2	2	2	410	45.8	8.65				2				2			417437	1182237.719			2	2												0
High	Q9H204	Mediator of RNA polymerase II transcription subunit 28 OS=Homo sapiens OX=9606 GN=MED28 PE=1 SV=1	0.004	2.25	5	1	2	1	178	19.5	5.58			1	1			1	1	163547.3594	286551.0625	266620.7813	328084.2813	1	1	1	1		metabolic process;regulation of biological process	cytoplasm;cytoskeleton;membrane;nucleus	protein binding	Pf11594	80306	ENSG00000118579.12	MED28	4	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression		0
High	P07686	Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=3	0	4.709	3	2	2	2	556	63.1	6.76				2				2				993592.7813				2		cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;reproduction;response to stimulus;transport	extracellular;membrane;organelle lumen;vacuole	catalytic activity;protein binding	"Pf00728, Pf14845"	3074		HEXB	5	Neutrophil degranulation; CS/DS degradation; Glycosphingolipid metabolism; Hyaluronan uptake and degradation; Keratan sulfate degradation	Lysosome; Glycosphingolipid biosynthesis - ganglio series; Glycosaminoglycan degradation; Amino sugar and nucleotide sugar metabolism; Other glycan degradation; Metabolic pathways; Glycosphingolipid biosynthesis - globo and isoglobo series	0
High	P30048	"Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3"	0.004	2.169	4	1	2	1	256	27.7	7.78	1	1			1	1			1002378.563	555776.9375		562144.875	1	1		1		cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endosome;mitochondrion;organelle lumen	antioxidant activity;catalytic activity;enzyme regulator activity;protein binding	"Pf00578, Pf08534, Pf10417, Pf13905"	10935	ENSG00000165672.6	PRDX3	10	Detoxification of Reactive Oxygen Species		0
Medium	Q4KWH8	"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1"	0.011	1.732	0	1	2	1	1693	189.1	7.74				1				2			606776.5625	11591855			1	1		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	catalytic activity;metal ion binding;protein binding;signal transducer activity	"Pf00036, Pf00168, Pf00387, Pf00388, Pf09279, Pf13499, Pf14788"	23007	ENSG00000114805.16	PLCH1	3	Synthesis of IP3 and IP4 in the cytosol	Inositol phosphate metabolism; Metabolic pathways	0
Medium	Q14684	Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3	0.043	1.178	2	1	2	1	758	84.4	9.76			1	1			1	1										metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	protein binding;RNA binding	Pf05997	23076	ENSG00000160208.12	RRP1B	21			0
High	P33240	Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1	0	3.917	3	2	2	2	577	60.9	6.83	2				2				1517145.813		221405.0938	145139.2188	2		1	1		metabolic process	nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259, Pf14304, Pf14327"	1478	ENSG00000101811.13	CSTF2	X	Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway; tRNA processing in the nucleus	mRNA surveillance pathway	0
Medium	O15160	DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1	0.011	1.732	3	1	2	1	346	39.2	5.5			1	1			1	1	215403.5	132282.75	261499.2188	256183.3906	1	1	1	1		metabolic process;regulation of biological process	cytosol;nucleus	catalytic activity;DNA binding;protein binding	"Pf01000, Pf01193"	9533	ENSG00000171453.17	POLR1C	6	RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase III Transcription Initiation From Type 2 Promoter	Epstein-Barr virus infection; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism	0
High	P41250	Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3	0	4.979	3	2	2	2	739	83.1	7.03			1	1			1	1	420041	1374489.5	1444636.891	1443500.703	1	1	2	2		metabolic process	cytoplasm;cytosol;extracellular;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding	"Pf00458, Pf00587, Pf03129"	2617	ENSG00000106105.13	GARS	7	Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation	Aminoacyl-tRNA biosynthesis	0
Medium	Q86W42	THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1	0.018	1.588	4	1	2	1	341	37.5	7.43	1		1		1		1		152973.4531	69632.29688	133062.0469		1	1	1			cell death;development;metabolic process;regulation of biological process;transport	nucleus	protein binding;RNA binding	Pf00400	79228	ENSG00000131652.13	THOC6	16	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing	RNA transport	0
Medium	P55083	Microfibril-associated glycoprotein 4 OS=Homo sapiens OX=9606 GN=MFAP4 PE=1 SV=2	0.048	1.121	2	1	2	1	255	28.6	5.63			1	1			1	1		405807.375	590758.9375	521017.75		1	1	1		cell organization and biogenesis;regulation of biological process;response to stimulus	extracellular	protein binding	Pf00147	4239	ENSG00000166482.11	MFAP4	17	Molecules associated with elastic fibres		0
High	Q9NVP2	Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1	0.007	1.928	4	1	2	1	202	22.4	4.56			1	1			1	1		271920.0625	814893.625	341785.7813		1	1	1		cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process	chromosome;nucleus	protein binding	Pf04729	55723	ENSG00000105011.8	ASF1B	19			0
High	P15586	N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3	0.001	3.398	5	2	2	2	552	62	8.31				2				2				580244.5938				2		metabolic process;transport	extracellular;organelle lumen;vacuole	catalytic activity;metal ion binding;protein binding	"Pf00884, Pf01663"	2799	ENSG00000135677.10	GNS	12	Neutrophil degranulation; MPS IIID - Sanfilippo syndrome D; Keratan sulfate degradation; Lysosome Vesicle Biogenesis	Lysosome; Glycosaminoglycan degradation; Metabolic pathways	0
High	P46087	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2	0.001	3.238	3	2	2	2	812	89.2	9.23	1		1		1		1		476929.2109	372279.8359	841265.875	861499.8438	2	2	2	2		cell organization and biogenesis;metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding;RNA binding	"Pf01189, Pf12847"	4839	ENSG00000111641.11	NOP2	12	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; rRNA modification in the nucleus and cytosol		0
High	Q9H4A3	Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2	0.001	3.36	1	2	2	2	2382	250.6	6.34		1	1			1	1			519312.125	622177.25	156429.875		2	2	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane	catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding	"Pf00069, Pf07714, Pf12202"	65125	ENSG00000060237.16	WNK1	12	Stimuli-sensing channels		0
High	O60306	RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4	0.001	3.122	1	2	2	2	1485	171.2	6.37	2				2				490388.5	148301.4375	101498.1328	83864.45313	2	1	1	1		metabolic process;response to stimulus	membrane;nucleus;spliceosomal complex	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf04851, Pf13086, Pf13087, Pf13245, Pf13538"	9716	ENSG00000021776.10	AQR	15	Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER	Spliceosome	0
High	Q9Y315	Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2	0	4.341	8	2	2	2	318	35.2	8.94	2				2				1249538.969				2					metabolic process;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen	catalytic activity	Pf01791	51071	ENSG00000023697.12	DERA	12	Neutrophil degranulation; Pentose phosphate pathway (hexose monophosphate shunt)	Pentose phosphate pathway	0
High	P61163	Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1	0.001	3.356	5	2	2	2	376	42.6	6.64	2				2				856694.5781		236374.1719	236568.9063	2		1	1		regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol	nucleotide binding;protein binding	Pf00022	10121	ENSG00000138107.12	ACTR1A	10	COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR)		0
High	Q9Y2R9	"28S ribosomal protein S7, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2"	0.001	2.901	12	2	2	2	242	28.1	9.99			1	1			1	1			257756.0625	259630.4531			1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	RNA binding;structural molecule activity	Pf00177	51081	ENSG00000125445.10	MRPS7	17	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination	Ribosome	0
High	P40939	"Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2"	0.001	3.031	3	2	2	2	763	82.9	9.04		1	1			1	1		552408.2344	254840.1563	442755.4844	647947.0938	2	1	2	2		metabolic process;response to stimulus	membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding	"Pf00378, Pf00725, Pf02737"	3030	ENSG00000084754.10	HADHA	2	Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA	"Butanoate metabolism; Fatty acid degradation; Propanoate metabolism; Carbon metabolism; Lysine degradation; beta-Alanine metabolism; Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Fatty acid metabolism"	0
High	P63244	Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3	0	5.406	5	1	2	1	317	35.1	7.69			1	1			1	1										cell death;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome	enzyme regulator activity;protein binding;RNA binding;structural molecule activity	Pf00400	10399	ENSG00000204628.11	GNB2L1; RACK1	5	Regulation of TNFR1 signaling; TNFR1-mediated ceramide production; TNFR1-induced NFkappaB signaling pathway	Measles	0
High	P20700	Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2	0.005	2.054	1	1	2	1	586	66.4	5.16		1	1			1	1		58110.49609	199345.8281	198608.5469	184610.8594	1	1	1	1		regulation of biological process;response to stimulus	membrane;nucleus	catalytic activity;motor activity;protein binding;structural molecule activity	"Pf00038, Pf00932, Pf01576, Pf07888, Pf09726, Pf09731, Pf10186, Pf12128"	4001	ENSG00000113368.11	LMNB1	5	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Breakdown of the nuclear lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Meiotic synapsis; Depolymerisation of the Nuclear Lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Interleukin-12 family signaling	Apoptosis	0
High	P19388	"DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4"	0	4.662	11	2	2	2	210	24.5	5.95	1			1	1			1	597373.375		368094.7891	629843.875	1		2	2		metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;DNA binding;protein binding	"Pf01191, Pf03871"	5434	ENSG00000099817.11	POLR2E	19	Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter	Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism	0
High	Q5HYI8	Rab-like protein 3 OS=Homo sapiens OX=9606 GN=RABL3 PE=1 SV=1	0.005	2.054	5	1	2	1	236	26.4	7.11			1	1			1	1	20075.04297	71407.9375	279206.4063	283416.7813	1	1	1	1		regulation of biological process;response to stimulus		nucleotide binding	"Pf00071, Pf08477"	285282	ENSG00000144840.8	RABL3	3			0
Medium	Q9BQE9	B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1	0.021	1.491	3	1	2	1	202	22.2	4.75	1	1			1	1			574749.9375	413881.7813	294569.8438	844025.375	1	1	1	1		cell death;cell differentiation;regulation of biological process;response to stimulus		protein binding	Pf04714	9275	ENSG00000106635.7	BCL7B	7			0
High	Q9HDC9	Adipocyte plasma membrane-associated protein OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2	0	4.397	5	2	2	2	416	46.5	6.16				2				2			248276.4922	1906912.063			2	2		metabolic process	cell surface;endoplasmic reticulum;membrane	catalytic activity	"Pf03088, Pf08450"	57136	ENSG00000101474.11	APMAP	20			0
High	Q14165	Malectin OS=Homo sapiens OX=9606 GN=MLEC PE=1 SV=1	0.001	2.704	10	2	2	2	292	32.2	5.41				2				2	131490.0625		263268.7188	687753.125	1		1	2		metabolic process;transport	endoplasmic reticulum;membrane	protein binding	Pf11721	9761	ENSG00000110917.7	MLEC	12	Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle		0
Medium	P60468	Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2	0.018	1.597	10	1	2	1	96	10	11.56			1	1			1	1	123343.7813	404867	714098.9375	1305217.625	1	1	1	1		metabolic process;transport	cytosol;endoplasmic reticulum;membrane	protein binding;RNA binding;transporter activity	Pf03911	10952	ENSG00000106803.9	SEC61B	9	ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane	Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection	0
High	Q96DI7	U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1	0.001	3.342	12	2	2	2	357	39.3	8.1		1		1		1		1	206370.3828	362796.8672	109268.7344	156655.4219	2	2	1	1		cell organization and biogenesis;metabolic process	cytosol;nucleus;spliceosomal complex	protein binding;RNA binding	Pf00400	9410	ENSG00000060688.12	SNRNP40	1	mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway	Spliceosome	0
Medium	Q6IQ20	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Homo sapiens OX=9606 GN=NAPEPLD PE=1 SV=2	0.014	1.715	2	1	2	1	393	45.6	6.06		1	1			1	1			1317092.125	2054412.375	2443519.75		1	1	1		metabolic process;response to stimulus	cytosol;membrane	catalytic activity;metal ion binding;protein binding	"Pf00753, Pf12706, Pf13483"	222236	ENSG00000161048.11; ENSG00000275723.4	NAPEPLD	7; CHR_HSCHR7_1_CTG4_4	"Signaling by GPCR; Biosynthesis of A2E, implicated in retinal degradation"	Retrograde endocannabinoid signaling	0
Medium	Q9UBM7	7-dehydrocholesterol reductase OS=Homo sapiens OX=9606 GN=DHCR7 PE=1 SV=1	0.011	1.772	2	1	2	1	475	54.5	8.7			1	1			1	1	75518.53125	231981.7969	562334.375	971051.4375	1	1	1	1		cell differentiation;metabolic process;regulation of biological process	cytosol;endoplasmic reticulum;membrane	catalytic activity;nucleotide binding	Pf01222	1717	ENSG00000172893.15	DHCR7	11	Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol; Activation of gene expression by SREBF (SREBP)	Steroid biosynthesis; Metabolic pathways	0
High	P62891	60S ribosomal protein L39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2	0.001	3.23	20	1	2	1	51	6.4	12.56			1	1			1	1	909282.5	1116361.375	1457181.5	654181.5625	1	1	1	1		cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport	cytosol;ribosome	RNA binding;structural molecule activity	Pf00832	6170; 285785	ENSG00000198918.7	RPL39; RPL39P3	X; 6	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
Medium	P07195	L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2	0.011	1.823	3	1	2	1	334	36.6	6.05		1	1			1	1		110849.4922	327319.6875	264883.0625	514727.7188	1	1	1	1		metabolic process	cytoplasm;cytosol;membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding	"Pf00056, Pf02866"	3945	ENSG00000111716.12	LDHB	12	Pyruvate metabolism	Propanoate metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Cysteine and methionine metabolism	0
High	Q96E14	RecQ-mediated genome instability protein 2 OS=Homo sapiens OX=9606 GN=RMI2 PE=1 SV=2	0.001	2.702	7	1	2	1	147	15.9	7.9		1	1			1	1			491712.7188	466321.6875	333111.6563		1	1	1		metabolic process;regulation of biological process	cytosol;nucleus	DNA binding;protein binding		116028	ENSG00000175643.8	RMI2	16	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Resolution of D-loop Structures through Holliday Junction Intermediates	Fanconi anemia pathway	0
High	P25788	Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2	0.001	3.134	4	1	2	1	255	28.4	5.33		1		1		1		1		321851.2813	218593.1875	505834.6875		1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding	"Pf00227, Pf10584"	5684	ENSG00000100567.12	PSMA3	14	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	O94808	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Homo sapiens OX=9606 GN=GFPT2 PE=1 SV=3	0	3.572	2	2	2	2	682	76.9	7.37				2				2		85542.8125	155419.3906	310736.75		1	2	2		metabolic process	cytosol	catalytic activity;protein binding	"Pf00310, Pf01380, Pf13230, Pf13522, Pf13537, Pf13580"	9945	ENSG00000131459.12	GFPT2	5	Synthesis of UDP-N-acetyl-glucosamine	"Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Insulin resistance"	0
High	P51688	N-sulphoglucosamine sulphohydrolase OS=Homo sapiens OX=9606 GN=SGSH PE=1 SV=1	0	5.778	5	2	2	2	502	56.7	6.95				2				2	273410.875		348682.2813	3137873.75	1		1	2		metabolic process	organelle lumen;vacuole	catalytic activity;metal ion binding	"Pf00884, Pf01663"	6448	ENSG00000181523.12	SGSH	17	HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A	Lysosome; Glycosaminoglycan degradation; Metabolic pathways	0
Medium	Q9NQH7	Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1	0.036	1.278	2	1	2	1	507	57	6.83		1		1		1		1	502088.2188	410793.0313	393422.125	486714.25	1	1	1	1		metabolic process	mitochondrion	catalytic activity;metal ion binding	"Pf00557, Pf05195"	63929	ENSG00000196236.12	XPNPEP3	22			0
High	Q9H4F1	"Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase OS=Homo sapiens OX=9606 GN=ST6GALNAC4 PE=2 SV=2"	0	4.413	6	2	2	2	302	34.2	8.57				2				2				1366836.5				2		metabolic process	Golgi;membrane	catalytic activity	Pf00777	27090	ENSG00000136840.18	ST6GALNAC4	9	Termination of O-glycan biosynthesis; Sialic acid metabolism	Glycosphingolipid biosynthesis - ganglio series; Metabolic pathways	0
Low	Q9NW64	Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1	0.056	1.019	4	1	2	1	420	46.9	8.54		1		1		1		1										cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;nucleus;spliceosomal complex	metal ion binding;nucleotide binding;protein binding;RNA binding;transporter activity	"Pf00076, Pf13893, Pf14259"	55696	ENSG00000086589.11	RBM22	5	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q9BQB6	Vitamin K epoxide reductase complex subunit 1 OS=Homo sapiens OX=9606 GN=VKORC1 PE=1 SV=1	0	4.331	8	1	2	1	163	18.2	9.36			1	1			1	1	72689.54688	221180.25	1125389.125	3017842.75	1	1	1	1		coagulation;metabolic process	endoplasmic reticulum;membrane	catalytic activity	Pf07884	79001	ENSG00000167397.14	VKORC1	16	Metabolism of vitamin K	Ubiquinone and other terpenoid-quinone biosynthesis	0
High	O95793	Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2	0	4.66	2	1	2	1	577	63.1	9.44			1	1			1	1		228502.625	384529.4375			1	1			regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;membrane	protein binding;RNA binding	"Pf00035, Pf14709"	6780	ENSG00000124214.19	STAU1	20			0
High	Q92598	Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1	0.001	2.718	3	2	2	2	858	96.8	5.39			1	1			1	1	366479.2578	191340.75	357931.9688	2006183.328	2	1	1	2		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen	enzyme regulator activity;nucleotide binding;protein binding	Pf00012	10808	ENSG00000120694.19	HSPH1	13	Scavenging by Class F Receptors; Regulation of HSF1-mediated heat shock response	Protein processing in endoplasmic reticulum	0
Medium	O60656	UDP-glucuronosyltransferase 1-9 OS=Homo sapiens OX=9606 GN=UGT1A9 PE=1 SV=1	0.036	1.255	1	1	2	1	530	59.9	7.9			1	1			1	1			383573.1875	380669.0938			1	1		metabolic process;regulation of biological process	endoplasmic reticulum;membrane	catalytic activity;enzyme regulator activity;protein binding	"Pf00201, Pf04101"	54600	ENSG00000241119.1	UGT1A9	2	Glucuronidation; PPARA activates gene expression	Ascorbate and aldarate metabolism; Metabolism of xenobiotics by cytochrome P450; Porphyrin and chlorophyll metabolism; Retinol metabolism; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Pentose and glucuronate interconversions; Metabolic pathways; Drug metabolism - other enzymes; Steroid hormone biosynthesis	0
High	Q7Z6E9	E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1	0.001	3.425	1	2	2	2	1792	201.4	9.64	1		1		1		1		202679.0469		165640.0156		1		1			metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;cytosol;nucleus	catalytic activity;metal ion binding;protein binding;RNA binding	"Pf00097, Pf00098, Pf08783, Pf10243, Pf13639, Pf13696, Pf13920, Pf13923, Pf14634, Pf15227"	5930	ENSG00000122257.18	RBBP6	16	Antigen processing: Ubiquitination & Proteasome degradation		0
High	Q9Y4R8	Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2	0.007	1.886	2	1	2	1	837	91.7	5.76			1	1			1	1			148909.1406	338439.8438			1	1		regulation of biological process	chromosome;cytoplasm;cytosol;membrane;nucleus	protein binding;structural molecule activity	Pf10193	9894	ENSG00000100726.14	TELO2	16		Fanconi anemia pathway; mTOR signaling pathway	0
High	Q8NAV1	Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1	0.003	2.405	3	1	2	1	312	37.5	9.96			1	1			1	1	3011907.5	3166493.75	3075662.25	3569685.5	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;nucleus;spliceosomal complex	protein binding;RNA binding	Pf03371	84950	ENSG00000134748.12	PRPF38A	1	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q8TF09	Dynein light chain roadblock-type 2 OS=Homo sapiens OX=9606 GN=DYNLRB2 PE=1 SV=1	0	5.234	23	2	2	2	96	10.8	7.5				2				2		182385.5313	262433.1563	529648.8125		1	1	1	Met-loss+Acetyl [N-Term]	cellular component movement;transport	cytoplasm;cytoskeleton	catalytic activity;motor activity;protein binding	Pf03259	83657	ENSG00000168589.14	DYNLRB2	16	Intraflagellar transport		0
High	P35606	Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2	0.001	2.839	2	2	2	2	906	102.4	5.27			1	1			1	1	37250.01953	191966.2188	382678.5469	452794.8359	1	2	2	2		transport	cytoplasm;cytosol;Golgi;membrane	protein binding;structural molecule activity	"Pf00400, Pf04053"	9276	ENSG00000184432.9	COPB2	3	COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport		0
High	P35998	26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3	0	3.731	3	2	2	2	433	48.6	5.95				2				2	87995.94531	141360.75	436117.2578	646778.2344	1	1	2	2		cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome	catalytic activity;nucleotide binding;protein binding	"Pf00004, Pf00158, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401"	5701	ENSG00000161057.11	PSMC2	7	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Epstein-Barr virus infection; Proteasome	0
High	Q9Y5A9	YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2	0.001	3.075	2	1	2	1	579	62.3	8.79			1	1			1	1	115464.9297	118141.0781	262780	342078.6563	1	1	1	1		cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	protein binding;RNA binding	Pf04146	51441	ENSG00000198492.15	YTHDF2	1			0
High	Q6P5R6	60S ribosomal protein L22-like 1 OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2	0	6.59	16	2	2	2	122	14.6	9.38				2				2	419943.9219	357845.75	900749.7969	1600981.156	2	1	2	2		metabolic process	ribosome	RNA binding;structural molecule activity	Pf01776	200916	ENSG00000163584.17	RPL22L1	3	Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane	Ribosome	0
High	Q96S16	JmjC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=JMJD8 PE=1 SV=2	0.001	3.393	7	2	2	2	264	29.5	6.64				2				2		27292.5957		2203882.188		1		2												0
Medium	Q9UKM9	RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1	0.046	1.136	3	1	2	1	306	32.4	9.17	1		1		1		1		164907.2344	216653.75	200630.375	181915.7656	1	1	1	1		metabolic process;regulation of biological process	nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	22913	ENSG00000125970.11	RALY	20			0
High	Q5JS37	NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=2 SV=1	0.001	2.905	4	1	2	1	347	38.3	6.43				1				2				709373.8125				1		transport	extracellular;organelle lumen	protein binding	Pf01436	387921	ENSG00000188811.13	NHLRC3	13	Neutrophil degranulation		0
High	Q9H3K2	Growth hormone-inducible transmembrane protein OS=Homo sapiens OX=9606 GN=GHITM PE=1 SV=2	0.002	2.659	3	1	2	1	345	37.2	9.94			1	1			1	1			1006729.563	806376.75			1	1		cell death	membrane;mitochondrion	protein binding		27069	ENSG00000165678.20	GHITM	10			0
High	Q9BT09	Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1	0.001	3.27	6	2	2	2	278	30.7	5.49				2				2	48231.41406			416762.625	1			2		defense response;regulation of biological process;response to stimulus	endoplasmic reticulum;organelle lumen	protein binding	Pf11938	10695	ENSG00000137161.16	CNPY3	6	Trafficking and processing of endosomal TLR		0
Medium	O43677	"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFC1 PE=1 SV=1"	0.032	1.309	11	1	2	1	76	8.7	10.2			1	1			1	1	508409.9375	911459.75	1066998.875	1194318.625	1	1	1	1		cell organization and biogenesis;metabolic process;transport	membrane;mitochondrion	catalytic activity	Pf15088	4717	ENSG00000109390.11	NDUFC1	4	Complex I biogenesis	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways	0
High	P53985	Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3	0	4.799	2	1	2	1	500	53.9	8.66				1				2				698694.8125				1		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	membrane;mitochondrion	protein binding;transporter activity	"Pf00083, Pf07690, Pf12832"	6566	ENSG00000281917.2; ENSG00000155380.11	SLC16A1	1; CHR_HG2104_PATCH	Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT); Basigin interactions; Pyruvate metabolism		0
High	P40937	Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1	0.004	2.286	3	1	2	1	340	38.5	7.2			1	1			1	1										cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00004, Pf03215, Pf05496, Pf06068, Pf08542, Pf13086, Pf13173, Pf13177, Pf13401, Pf13479"	5985	ENSG00000111445.13	RFC5	12	Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA)	DNA replication; Mismatch repair; Nucleotide excision repair	0
High	Q02224	Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2	0.003	2.459	1	2	2	2	2701	316.2	5.64	2				2				520183.75				2					cell division;cell organization and biogenesis;cellular component movement;development;regulation of biological process;transport	chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity	"Pf00225, Pf01496, Pf02463, Pf04156, Pf05557, Pf06160, Pf08317, Pf10186, Pf12128, Pf13166"	1062	ENSG00000138778.11	CENPE	4	COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation		0
High	Q9NRP0	Oligosaccharyltransferase complex subunit OSTC OS=Homo sapiens OX=9606 GN=OSTC PE=1 SV=1	0.001	3.043	8	1	2	1	149	16.8	9.13			1	1			1	1		349510.4063	570243.375	992789.6875		1	1	1		metabolic process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf04756	58505	ENSG00000198856.12	OSTC	4			0
High	Q9H6R7	WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1	0.001	2.779	1	1	2	1	721	79.1	6.7	1				2				444630.8125				1					cell organization and biogenesis		protein binding	Pf15390	80304	ENSG00000163026.11	C2orf44; WDCP	2			0
Medium	O15042	U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2	0.04	1.2	1	1	2	1	1029	118.2	8.47	1			1	1			1	148160.6094			275840.0313	1			1		metabolic process	nucleus	protein binding;RNA binding	"Pf00076, Pf01805, Pf08312, Pf13893, Pf14259"	23350	ENSG00000163714.17	U2SURP	3	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q9NWZ5	Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2	0.004	2.131	1	1	2	1	548	61.1	7.36	1	1			1	1												metabolic process	cytoplasm;cytosol;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00485, Pf07931, Pf13207, Pf14681"	54963	ENSG00000198276.15	UCKL1	20	Pyrimidine salvage	Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes	0
High	Q8IYT4	Katanin p60 ATPase-containing subunit A-like 2 OS=Homo sapiens OX=9606 GN=KATNAL2 PE=1 SV=3	0.005	2.049	2	1	2	1	538	61.2	7.56	1	1			1	1			315589.4688	245125.4375	1158628	502027.9375	1	1	1	1		metabolic process;response to stimulus	cytoplasm;cytoskeleton;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf07724, Pf07728, Pf08513, Pf13479"	83473	ENSG00000167216.16	KATNAL2	18			0
High	Q9NZ45	CDGSH iron-sulfur domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CISD1 PE=1 SV=1	0.004	2.225	12	1	2	1	108	12.2	9.09			1	1			1	1			103910.1875	206219.875			1	1		regulation of biological process	membrane;mitochondrion	metal ion binding;protein binding	Pf09360	55847	ENSG00000122873.11	CISD1	10			0
High	O60934	Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1	0.003	2.417	3	2	2	2	754	84.9	6.9		2				2			59451.74609	653562.2188	160878.9688	110723.5547	1	2	1	1		cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	chromosome;cytosol;nucleus	catalytic activity;DNA binding;protein binding	"Pf00498, Pf00533, Pf08599"	4683	ENSG00000104320.13	NBN	8	G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates	Homologous recombination	0
High	Q9NVN8	Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1	0.003	2.578	4	2	2	2	582	65.5	8.44	1			1	1			1	419594.2188	443950.3125	247263.5938	718119	2	2	1	2		regulation of biological process	cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf01926, Pf02421, Pf11849"	54552	ENSG00000130119.15	GNL3L	X		Ribosome biogenesis in eukaryotes	0
High	Q9H4M3	F-box only protein 44 OS=Homo sapiens OX=9606 GN=FBXO44 PE=1 SV=3	0	5.928	9	1	2	1	255	29.7	5.82			1	1			1	1			623126.0625	329327.375			1	1	Met-loss [N-Term]	metabolic process	cytosol	catalytic activity;protein binding	"Pf00646, Pf04300, Pf12937"	93611	ENSG00000132879.13	FBXO44	1	Antigen processing: Ubiquitination & Proteasome degradation; Neddylation		0
High	Q15528	Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2	0.004	2.136	7	1	2	1	200	22.2	4.68	1	1			1	1			319663.7813	346618.7813	257509.3438	462545.9688	1	1	1	1		metabolic process;regulation of biological process	cytoplasm;nucleus	protein binding	Pf06179	6837	ENSG00000281022.2; ENSG00000148297.15	MED22	9; CHR_HG2030_PATCH	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression		0
High	Q96G23	Ceramide synthase 2 OS=Homo sapiens OX=9606 GN=CERS2 PE=1 SV=1	0	3.852	4	1	2	1	380	44.8	8.98			1	1			1	1			505173.1563	278363.7188			1	1		metabolic process;regulation of biological process	endoplasmic reticulum;membrane;nucleus	catalytic activity;DNA binding;protein binding	Pf03798	29956	ENSG00000143418.19	CERS2	1	Sphingolipid de novo biosynthesis	Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways	0
High	Q8NBP0	Tetratricopeptide repeat protein 13 OS=Homo sapiens OX=9606 GN=TTC13 PE=2 SV=3	0.001	2.726	2	1	2	1	860	96.8	7.01		1	1			1	1		9444947.875	15280858	13637472.38	19142186.75	1	1	1	1				protein binding	"Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559"	79573	ENSG00000143643.12	TTC13	1			0
High	Q9P086	Mediator of RNA polymerase II transcription subunit 11 OS=Homo sapiens OX=9606 GN=MED11 PE=1 SV=2	0	4.026	24	2	2	2	117	13.1	5.96	1		1		1		1		350180.5938	372111.5	250110.1563	422585.9375	1	1	1	1	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding	Pf10280	400569	ENSG00000161920.9	MED11	17	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression		0
Medium	Q969S9	"Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1"	0.018	1.604	1	1	2	1	779	86.5	6.51			1	1			1	1	25743.02344		271526.5313	546325.4375	1		1	1		cell organization and biogenesis;metabolic process	mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf00679, Pf01926, Pf03144, Pf03764, Pf14492"	84340	ENSG00000164347.17	GFM2	5	Mitochondrial translation termination		0
High	Q9BVX2	Transmembrane protein 106C OS=Homo sapiens OX=9606 GN=TMEM106C PE=1 SV=1	0	6.066	7	1	2	1	250	27.9	6.77				1				2											endoplasmic reticulum;membrane	protein binding	Pf07092	79022	ENSG00000134291.11	TMEM106C	12			0
High	A1L0T0	2-hydroxyacyl-CoA lyase 2 OS=Homo sapiens OX=9606 GN=ILVBL PE=1 SV=2	0	4.583	4	2	2	2	632	67.8	8.15				2				2											membrane	catalytic activity;metal ion binding;protein binding	"Pf00205, Pf02775, Pf02776"	10994	ENSG00000105135.15	ILVBL	19			0
High	Q15758	Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2	0.002	2.616	2	1	2	1	541	56.6	5.48			1	1			1	1			1491854.375	972640.625			1	1		transport	membrane	protein binding;receptor activity;transporter activity	Pf00375	6510	ENSG00000105281.12	SLC1A5	19	Amino acid transport across the plasma membrane	Central carbon metabolism in cancer; Protein digestion and absorption	0
Medium	O95292	Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3	0.019	1.564	6	1	2	1	243	27.2	7.3			1	1			1	1	264103.125	435759	641410.875	627175.875	1	1	1	1		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;Golgi;membrane	protein binding	"Pf00635, Pf00843"	9217	ENSG00000124164.15	VAPB	20	Sphingolipid de novo biosynthesis		0
Medium	P62191	26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1	0.011	1.835	2	1	2	1	440	49.2	6.21			1	1			1	1	87995.94531	141360.75	678493.0938	505979.5625	1	1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00910, Pf01078, Pf05496, Pf05673, Pf05729, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401"	5700	ENSG00000100764.13	PSMC1	14	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Viral carcinogenesis; Epstein-Barr virus infection; Proteasome	0
High	Q8NCH0	Carbohydrate sulfotransferase 14 OS=Homo sapiens OX=9606 GN=CHST14 PE=1 SV=2	0.001	3.115	5	2	2	2	376	43	9.48				2				2				1223595.375				1		metabolic process	Golgi;membrane	catalytic activity	Pf03567	113189	ENSG00000169105.7	CHST14	15	"Defective CHST14 causes EDS, musculocontractural type; Dermatan sulfate biosynthesis"	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0
High	P22695	"Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3"	0	5.43	5	2	2	2	453	48.4	8.63				2				2		137802.2188	405754.2656	887981.75		1	2	2		metabolic process;transport	membrane;mitochondrion	catalytic activity;metal ion binding;protein binding	"Pf00675, Pf05193"	7385	ENSG00000140740.10; ENSG00000284493.1	UQCRC2	16; CHR_HG926_PATCH	Respiratory electron transport	Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Cardiac muscle contraction	0
High	Q9BRX9	WD repeat domain-containing protein 83 OS=Homo sapiens OX=9606 GN=WDR83 PE=1 SV=1	0.004	2.282	4	1	2	1	315	34.3	5.58	1	1			1	1			85893.35938	115997.2656	155041.7969		1	1	1			metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus;spliceosomal complex	protein binding	Pf00400	84292	ENSG00000123154.11	WDR83	19	MAP2K and MAPK activation; Interleukin-20 family signaling		0
High	Q9UGN5	Poly [ADP-ribose] polymerase 2 OS=Homo sapiens OX=9606 GN=PARP2 PE=1 SV=2	0	4.716	4	2	2	2	583	66.2	8.88		2				2				1198340.438	650615.2969	603348.5		2	2	1		metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	catalytic activity;DNA binding;protein binding	"Pf00644, Pf02877, Pf05406"	10038	ENSG00000129484.13	PARP2	14	Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; POLB-Dependent Long Patch Base Excision Repair; HDR through MMEJ (alt-NHEJ); Dual Incision in GG-NER	Base excision repair; Apoptosis	0
High	Q8IZ52	Chondroitin sulfate synthase 2 OS=Homo sapiens OX=9606 GN=CHPF PE=1 SV=2	0	3.561	3	2	2	2	775	85.4	6.93				2				2				809595.125				2		metabolic process	cytoplasm;cytosol;Golgi;membrane;mitochondrion;organelle lumen	catalytic activity;metal ion binding;protein binding	"Pf02434, Pf05679"	79586	ENSG00000123989.13	CHPF	2	Chondroitin sulfate biosynthesis	Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0
Medium	P51114	Fragile X mental retardation syndrome-related protein 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3	0.046	1.128	1	1	2	1	621	69.7	6.15			1	1			1	1	1250215.75	391488.7813	1900329.25	1929585.625	1	1	1	1		cell death;cell differentiation;development;regulation of biological process	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	"Pf00013, Pf05641, Pf12235, Pf13014"	8087	ENSG00000114416.17	FXR1	3	Signaling by BRAF and RAF fusions	RNA transport	0
Medium	Q9NXE8	Pre-mRNA-splicing factor CWC25 homolog OS=Homo sapiens OX=9606 GN=CWC25 PE=1 SV=1	0.035	1.288	2	1	2	1	425	49.6	10.18	1				2				269876.3125	276626.5313	433988.0313	239315.8125	1	1	1	1		metabolic process			"Pf10197, Pf12542"	54883	ENSG00000273559.4; ENSG00000276761.2	CWC25	17; CHR_HSCHR17_7_CTG4	mRNA Splicing - Major Pathway		0
High	O43505	"Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GAT1 PE=1 SV=1"	0	6.239	6	2	2	2	415	47.1	7.2				2				2		90241.95313	322478.7188	1055994.469		1	1	2		cellular component movement;metabolic process	Golgi;membrane	catalytic activity;metal ion binding;protein binding	Pf13896	11041	ENSG00000174684.6	B3GNT1; B4GAT1	11	Keratan sulfate biosynthesis; O-linked glycosylation	Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways; Glycosaminoglycan biosynthesis - keratan sulfate	0
Low	Q96HD1	Protein disulfide isomerase CRELD1 OS=Homo sapiens OX=9606 GN=CRELD1 PE=1 SV=3	0.057	0.994	2	1	2	1	420	45.4	4.87			1	1			1	1	244151.2813	579788.3125	589914.625	786957.5	1	1	1	1			membrane	metal ion binding	"Pf07645, Pf11938"	78987	ENSG00000163703.17	CRELD1	3			0
High	Q15904	V-type proton ATPase subunit S1 OS=Homo sapiens OX=9606 GN=ATP6AP1 PE=1 SV=2	0	9.377	6	2	2	2	470	52	6.14				2				2				267404.4063				1		cellular homeostasis;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane	catalytic activity;nucleotide binding;protein binding;transporter activity	Pf05827	537	ENSG00000071553.16	ATP6AP1	X	Transferrin endocytosis and recycling; Ion channel transport; Insulin receptor recycling	Lysosome; Hepatitis B; Tuberculosis; Phagosome; Oxidative phosphorylation; Vibrio cholerae infection; Metabolic pathways; Epithelial cell signaling in Helicobacter pylori infection; Rheumatoid arthritis	0
High	Q93009	Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2	0.004	2.289	1	1	2	1	1102	128.2	5.55		1	1			1	1		69629.8125	173505.5469	215186.4688	126422.875	1	1	1	1		cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;protein binding	"Pf00443, Pf00917, Pf12436, Pf13423, Pf14533"	7874	ENSG00000187555.14	USP7	16	Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization	Viral carcinogenesis; FoxO signaling pathway; Epstein-Barr virus infection; Herpes simplex infection	0
Medium	Q92917	G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2	0.043	1.15	1	1	2	1	476	52.2	6.15		1	1			1	1		590954.1875	535244.25	595081.75	859834.0625	1	1	1	1		metabolic process	nucleus	protein binding	"Pf00467, Pf01585, Pf12656"	27238	ENSG00000068394.10	GPKOW	X	mRNA Splicing - Major Pathway		0
High	Q14703	Membrane-bound transcription factor site-1 protease OS=Homo sapiens OX=9606 GN=MBTPS1 PE=1 SV=1	0	6.172	2	2	2	2	1052	117.7	8.75				2				2	39353.22656			1152608.969	1			2		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;Golgi;membrane;organelle lumen	catalytic activity	"Pf00082, Pf14258"	8720	ENSG00000140943.16	MBTPS1	16	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Assembly of active LPL and LIPC lipase complexes; Regulation of cholesterol biosynthesis by SREBP (SREBF); CREB3 factors activate genes; ATF6 (ATF6-alpha) activates chaperones	Protein processing in endoplasmic reticulum	0
High	P16278	Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2	0	5.906	3	2	2	2	677	76	6.57				2				2				876103.2188				2		metabolic process;response to stimulus;transport	cytoplasm;extracellular;Golgi;organelle lumen;vacuole	catalytic activity;protein binding	"Pf01301, Pf02449, Pf13364"	2720		GLB1	3	Sialic acid metabolism; Neutrophil degranulation; MPS IV - Morquio syndrome B; Glycosphingolipid metabolism; HS-GAG degradation; Keratan sulfate degradation	Lysosome; Glycosphingolipid biosynthesis - ganglio series; Galactose metabolism; Glycosaminoglycan degradation; Sphingolipid metabolism; Other glycan degradation; Metabolic pathways	0
High	P29122	Proprotein convertase subtilisin/kexin type 6 OS=Homo sapiens OX=9606 GN=PCSK6 PE=1 SV=1	0	4.405	2	2	2	2	969	106.4	7.68				2				2			158413.9531	1733251.188			1	2		cell death;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;extracellular;membrane;organelle lumen	catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity	"Pf00082, Pf00757, Pf01483, Pf03302, Pf08686, Pf14843"	5046	ENSG00000140479.16	PCSK6	15	Signaling by NODAL; Assembly of active LPL and LIPC lipase complexes; Formation of the cornified envelope; Signalling by NGF; NGF processing		0
High	Q9NZV5	Selenoprotein N OS=Homo sapiens OX=9606 GN=SELENON PE=1 SV=5	0	5.675	4	2	2	2	590	65.8	5.48				2				2			155417.7813	2367282			1	2		metabolic process;regulation of biological process	endoplasmic reticulum;membrane	catalytic activity;metal ion binding;protein binding		57190	ENSG00000162430.16	SEPN1; SELENON	1			0
High	P00338	L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2	0	4.458	6	2	2	2	332	36.7	8.27				2				2	544084.2266	725200.125	235248.5	1120165.25	2	2	1	2		metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00056, Pf02866"	3939	ENSG00000134333.13	LDHA	11	Pyruvate metabolism	Propanoate metabolism; HIF-1 signaling pathway; Central carbon metabolism in cancer; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Cysteine and methionine metabolism	0
Medium	P35251	Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4	0.018	1.586	1	1	2	1	1148	128.2	9.36			1	1			1	1										cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding	"Pf00004, Pf00533, Pf03215, Pf05496, Pf06414, Pf08519, Pf12738, Pf13207, Pf13238"	5981	ENSG00000035928.15	RFC1	4	Translesion synthesis by POLK; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Dual incision in TC-NER; PCNA-Dependent Long Patch Base Excision Repair	DNA replication; Mismatch repair; Nucleotide excision repair	0
High	P48651	Phosphatidylserine synthase 1 OS=Homo sapiens OX=9606 GN=PTDSS1 PE=1 SV=1	0.005	1.992	2	1	2	1	473	55.5	8.43		1	1			1	1		51852.13281	117942.1797			1	1				metabolic process	endoplasmic reticulum;membrane	catalytic activity	Pf03034	9791	ENSG00000156471.12	PTDSS1	8	Synthesis of PS	Glycerophospholipid metabolism; Metabolic pathways	0
High	Q9UBS4	DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1	0	5.057	8	2	2	2	358	40.5	6.18				2				2		561106	163958.0938	1314748.313		1	1	2		metabolic process;regulation of biological process	cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen	protein binding	"Pf00226, Pf01556"	51726	ENSG00000090520.11	DNAJB11	3	XBP1(S) activates chaperone genes	Protein processing in endoplasmic reticulum	0
High	O00743	Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1	0.005	2.033	2	1	2	1	305	35.1	5.69			1	1			1	1	40550.19531	116663.5547	139327.4375	174879.3438	1	1	1	1		cell organization and biogenesis;metabolic process	cytoplasm;cytosol;membrane	catalytic activity;metal ion binding;protein binding	Pf00149	5537	ENSG00000119414.11	PPP6C	9	COPII (Coat Protein 2) Mediated Vesicle Transport		0
High	Q13011	"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2"	0	4.291	6	2	2	2	328	35.8	8		1		1		1		1	1406557.75	882279.25	643335.5	1369187.594	1	1	1	2		metabolic process	membrane;mitochondrion	catalytic activity;protein binding	Pf00378	1891	ENSG00000282853.1; ENSG00000104823.8	ECH1	19; CHR_HG26_PATCH		Peroxisome	0
Medium	O60437	Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4	0.041	1.192	1	1	2	1	1756	204.6	5.6			1				2		107530102.3	143949207.5	125579326.1	154586522.7	1	1	1	1		cell death;cell organization and biogenesis;metabolic process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus	protein binding;structural molecule activity	Pf04111	5493	ENSG00000118898.15	PPL	16	Butyrophilin (BTN) family interactions; Formation of the cornified envelope		0
Medium	Q9Y2A7	Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1	0.042	1.177	1	1	2	1	1128	128.7	6.62			1				2			2277795.75	3873991.5	4010652.5		1	1	1		cell death;cell organization and biogenesis;regulation of biological process;response to stimulus	cytosol;membrane	protein binding	Pf09735	10787	ENSG00000061676.14	NCKAP1	2	Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs	Regulation of actin cytoskeleton	0
High	Q6UWL2	Sushi domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUSD1 PE=1 SV=1	0	6.82	3	2	2	2	747	82.7	6.43				2				2				2295282.375				2			cell surface;membrane	metal ion binding;protein binding	"Pf00008, Pf00084, Pf06247, Pf07645, Pf12947"	64420	ENSG00000106868.16	SUSD1	9			0
High	O43150	"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ASAP2 PE=1 SV=3"	0.001	2.83	1	1	2	1	1006	111.6	6.68			1				2		32535458.31	46111455.97	33894528.28	45227943.44	2	2	2	2		regulation of biological process	cytoplasm;Golgi;membrane	enzyme regulator activity;metal ion binding;protein binding	"Pf00018, Pf00023, Pf00169, Pf01412, Pf07653, Pf12796, Pf13637, Pf13857, Pf14604"	8853	ENSG00000151693.9	ASAP2	2		Endocytosis; Fc gamma R-mediated phagocytosis	0
High	A0FGR8	Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1	0	3.65	3	2	2	2	921	102.3	9.26				2				2	81207.75	173673.25	247690.4375	306491.4688	1	1	1	1		metabolic process;transport	endoplasmic reticulum;membrane	metal ion binding;protein binding	Pf00168	57488		ESYT2	7	Glycosphingolipid metabolism		0
High	P11182	"Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=3"	0	3.853	5	2	2	2	482	53.5	8.51	2				2				396266.9531				2					metabolic process	mitochondrion;organelle lumen	catalytic activity;protein binding	"Pf00198, Pf00364, Pf02817"	1629		DBT	1	Branched-chain amino acid catabolism; Glyoxylate metabolism and glycine degradation	"Propanoate metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation"	0
High	Q13501	Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1	0.001	2.793	6	1	2	1	440	47.7	5.22	1			1	1			1	533535.875			366256.5625	1			1		cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;endosome;nucleus;vacuole	catalytic activity;metal ion binding;protein binding	"Pf00564, Pf00569"	8878	ENSG00000161011.19	SQSTM1	5	Interleukin-1 family signaling; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes; NRIF signals cell death from the nucleus; Pink/Parkin Mediated Mitophagy	Osteoclast differentiation	0
High	O75787	Renin receptor OS=Homo sapiens OX=9606 GN=ATP6AP2 PE=1 SV=2	0	4.236	5	2	2	2	350	39	6.1				2				2			150942.7969	1124485.563			1	2		cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	membrane	protein binding;receptor activity;transporter activity	Pf07850	10159	ENSG00000182220.14	ATP6AP2	X	Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation	Renin-angiotensin system	0
High	Q9P2I0	Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2	0	4.132	2	1	2	1	782	88.4	5.11	1		1		1		1											metabolic process;transport	membrane;nucleus	protein binding;RNA binding	"Pf00753, Pf07521, Pf10996, Pf12706, Pf13299"	53981	ENSG00000165934.12	CPSF2	14	mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs	mRNA surveillance pathway	0
High	O60225	Protein SSX5 OS=Homo sapiens OX=9606 GN=SSX5 PE=1 SV=3	0.003	2.508	10	1	2	1	188	21.6	9.36	1			1	1			1	492734.2813	1342733.719	1638628.219	1733583.563	1	1	1	1		metabolic process;regulation of biological process	nucleus	protein binding	Pf09514	6758	ENSG00000165583.14	SSX5	X			0
Medium	A6NDN3	Golgin subfamily A member 6B OS=Homo sapiens OX=9606 GN=GOLGA6B PE=3 SV=3	0.032	1.31	2	1	2	1	693	79.9	5.5		1		1		1		1	1693230.5	2285113.5	2267710.75	2602629.5	1	1	1	1		regulation of biological process	Golgi		"Pf10186, Pf15070"	55889	ENSG00000215186.6	GOLGA6B	15			0
Low	O95429	BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1	0.051	1.091	2	1	2	1	457	49.6	5.12		1	1			1	1		172223	232772.5	208144.3906	322124.3125	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	enzyme regulator activity;nucleotide binding;protein binding;RNA binding;signal transducer activity	Pf02179	9530	ENSG00000156735.10	BAG4	8	Regulation of HSF1-mediated heat shock response; TNF signaling; Signaling by plasma membrane FGFR1 fusions	TNF signaling pathway	0
Medium	P21912	"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3"	0.015	1.682	4	1	2	1	280	31.6	8.76	1				2													metabolic process;transport	membrane;mitochondrion	catalytic activity;metal ion binding;protein binding	"Pf13085, Pf13183, Pf13534"	6390	ENSG00000117118.9	SDHB	1	Respiratory electron transport; Citric acid cycle (TCA cycle)	Citrate cycle (TCA cycle); Carbon metabolism; Huntington's disease; Parkinson's disease; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways	0
High	Q7LGA3	Heparan sulfate 2-O-sulfotransferase 1 OS=Homo sapiens OX=9606 GN=HS2ST1 PE=1 SV=1	0	5.473	6	2	2	2	356	41.9	8.69				2				2		345461.5781	521485.2031	1159564.531		2	2	2		metabolic process	Golgi;membrane	catalytic activity	Pf03567	9653	ENSG00000153936.16	HS2ST1	1	HS-GAG biosynthesis	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0
High	Q9Y490	Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3	0.004	2.125	0	1	2	1	2541	269.6	6.07		1	1			1	1			112833.4375	206340.6563			1	1			cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytoskeleton;cytosol;extracellular;membrane	protein binding;structural molecule activity	"Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379"	7094	ENSG00000137076.20	TLN1	9	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; XBP1(S) activates chaperone genes; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling	Rap1 signaling pathway; HTLV-I infection; Focal adhesion; Platelet activation	0
High	Q9Y2U8	Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2	0.004	2.203	3	1	2	1	911	99.9	7.55			1	1			1	1			214160.3438				1			cell organization and biogenesis;regulation of biological process	membrane;nucleus	DNA binding;protein binding	"Pf03020, Pf09402"	23592	ENSG00000174106.2	LEMD3	12	Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin		0
Medium	Q9BY77	Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2	0.021	1.525	3	1	2	1	421	46.1	9.99	1	1			1	1			134295.5938	218692.6094	247168.2344	273323.5625	1	1	1	1		metabolic process;regulation of biological process;transport	cytoplasm;cytosol;nucleus	protein binding;RNA binding	"Pf00076, Pf13893, Pf14259"	84271	ENSG00000100227.17	POLDIP3	22	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing		0
Low	Q9P2D0	Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3	0.051	1.094	1	1	2	1	1353	150.4	7.71			1	1			1	1	1495174.375	2063791.625	2767795.25	2392486.75	1	1	1	1		cellular homeostasis;regulation of biological process;transport	cytoplasm;membrane;nucleus	enzyme regulator activity;protein binding	"Pf00023, Pf00415, Pf00651, Pf12796, Pf13254, Pf13540, Pf13637, Pf13857"	25998	ENSG00000283068.1; ENSG00000005700.14	IBTK	6; CHR_HG2072_PATCH			0
High	O43324	Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1	0.001	2.934	6	1	2	1	174	19.8	8.54	1			1	1			1	302268.5313	136361.375	194738.6094	384528.9063	1	1	1	1		metabolic process;regulation of biological process	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	"Pf00043, Pf13410, Pf14497"	9521	ENSG00000124802.11	EEF1E1	6	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins		0
High	Q96G25	Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2	0	3.899	8	2	2	2	268	29.1	7.44			2				2			1277022.063	1753142.906	401289.5938		2	2	1		metabolic process;regulation of biological process	nucleus	protein binding	Pf10232	112950	ENSG00000159479.16	MED8	1	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Herpes simplex infection	0
High	Q5JPE7	Nodal modulator 2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1	0.002	2.62	2	2	2	2	1267	139.4	5.76				2				2		68461.8125	86751.60938	805965.2188		1	1	2		regulation of biological process	endoplasmic reticulum;membrane	protein binding	"Pf09430, Pf13620, Pf13715, Pf14686"	283820	ENSG00000185164.14	NOMO2	16			0
High	Q13724	Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5	0	5.406	4	2	2	2	837	91.9	8.9				2				2	441211.7188	568894.1875	644196.125	1385021.875	1	1	1	1		metabolic process	endoplasmic reticulum;membrane	catalytic activity	Pf03200	7841	ENSG00000115275.11	MOGS	2	Defective MOGS causes MOGS-CDG (CDG-2b); N-glycan trimming in the ER and Calnexin/Calreticulin cycle	N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways	0
High	P11310	"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1"	0	6.717	6	2	2	2	421	46.6	8.37				2				2	99082.39063	86638.75	110769.7266	810055.4688	1	1	1	2		metabolic process;regulation of biological process	membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding	"Pf00441, Pf02770, Pf02771, Pf08028, Pf11794"	34	ENSG00000117054.13	ACADM	1	PPARA activates gene expression; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA	"Fatty acid degradation; Propanoate metabolism; Carbon metabolism; PPAR signaling pathway; beta-Alanine metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation; Fatty acid metabolism"	0
High	P25789	Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1	0	5.023	8	2	2	2	261	29.5	7.72				2				2		128347.4063	196223.9063	1012353.875		1	2	2		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;protein binding	"Pf00227, Pf10584"	5685	ENSG00000041357.15	PSMA4	15	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	P30041	Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3	0.001	3.251	14	2	2	2	224	25	6.38		1		1		1		1		967295.5	4129052.5	4227966.563		2	2	2	Met-loss [N-Term]	cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;vacuole	antioxidant activity;catalytic activity;protein binding	"Pf00578, Pf08534, Pf10417"	9588	ENSG00000117592.8	PRDX6	1	Neutrophil degranulation; Detoxification of Reactive Oxygen Species	Metabolic pathways	0
High	P13489	Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2	0.003	2.513	7	2	2	2	461	49.9	4.82			1	1			1	1	39585.74219	153760.8438	264513.2188	441365.2656	1	1	2	2		metabolic process;regulation of biological process	cytoplasm;cytosol	enzyme regulator activity;protein binding		6050	ENSG00000276230.4; ENSG00000023191.16	RNH1	11; CHR_HSCHR11_1_CTG8			0
High	Q8WWM7	Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2	0	3.526	2	2	2	2	1075	113.3	8.59			1	1			1	1	410437.5938	168042.4219	505002	409891.8594	2	1	2	2		cell organization and biogenesis;regulation of biological process	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	"Pf06741, Pf07145, Pf09770, Pf14438"	11273	ENSG00000168488.18	ATXN2L	16			0
High	Q14444	Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2	0.001	3.321	2	1	2	1	709	78.3	5.25			1	1			1	1	420423.0313	298959.6563	419730.25	454039.0313	1	1	1	1		cell differentiation;regulation of biological process	cytoplasm;cytosol;membrane	protein binding;RNA binding	Pf12287	4076	ENSG00000135387.20	CAPRIN1	11			0
High	Q04206	Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2	0.001	2.746	3	2	2	2	551	60.2	5.68	1	1			1	1			2015648.188	1747456.422	2143345.492	2073695.375	2	2	2	1		defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	DNA binding;protein binding	Pf00554	5970	ENSG00000173039.18	RELA	11	CLEC7A/inflammasome pathway; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Regulated proteolysis of p75NTR; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 processing; PKMTs methylate histone lysines; FCERI mediated NF-kB activation; CD209 (DC-SIGN) signaling; Activation of NF-kappaB in B cells; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; NF-kB is activated and signals survival; Dectin-1 mediated noncanonical NF-kB signaling; Signalling by NGF; IkBA variant leads to EDA-ID; Senescence-Associated Secretory Phenotype (SASP)	Viral carcinogenesis; Chagas disease (American trypanosomiasis); Th1 and Th2 cell differentiation; Inflammatory bowel disease (IBD); Amoebiasis; T cell receptor signaling pathway; TNF signaling pathway; NOD-like receptor signaling pathway; Osteoclast differentiation; Hepatitis B; HIF-1 signaling pathway; Pancreatic cancer; Prolactin signaling pathway; Chronic myeloid leukemia; Antifolate resistance; Epstein-Barr virus infection; Neurotrophin signaling pathway; B cell receptor signaling pathway; Leishmaniasis; Acute myeloid leukemia; MAPK signaling pathway; Pathways in cancer; Prostate cancer; NF-kappa B signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Tuberculosis; Pertussis; HTLV-I infection; Toxoplasmosis; Apoptosis; Cytosolic DNA-sensing pathway; Salmonella infection; Transcriptional misregulation in cancer; Non-alcoholic fatty liver disease (NAFLD); Cocaine addiction; Sphingolipid signaling pathway; Measles; Small cell lung cancer; Toll-like receptor signaling pathway; Herpes simplex infection; Hepatitis C; Ras signaling pathway; RIG-I-like receptor signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway; cAMP signaling pathway; Influenza A; Legionellosis; Insulin resistance; Adipocytokine signaling pathway; Longevity regulating pathway; PI3K-Akt signaling pathway; Shigellosis	0
High	Q8NDZ4	Divergent protein kinase domain 2A OS=Homo sapiens OX=9606 GN=DIPK2A PE=1 SV=1	0	3.604	6	2	2	2	430	49.5	8.53				2				2				325996.4375				1		cell proliferation;regulation of biological process	extracellular;Golgi;membrane		Pf12260	205428	ENSG00000181744.8	C3orf58	3			0
High	Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta OS=Homo sapiens OX=9606 GN=ATF6B PE=1 SV=2	0.001	3.287	4	2	2	2	703	76.7	6.27				2				2	8934.867188		78445.42188	401437.9688	1		1	2	Met-loss+Acetyl [N-Term]	metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;Golgi;membrane;nucleus	DNA binding;protein binding	"Pf00170, Pf07716"	1388	ENSG00000228628.8; ENSG00000234539.9; ENSG00000213676.10; ENSG00000168468.12	ATF6B	6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1		Viral carcinogenesis; Dopaminergic synapse; TNF signaling pathway; Hepatitis B; Amphetamine addiction; cGMP-PKG signaling pathway; Protein processing in endoplasmic reticulum; Insulin secretion; Adrenergic signaling in cardiomyocytes; Thyroid hormone synthesis; Aldosterone synthesis and secretion; Cocaine addiction; Alcoholism; Estrogen signaling pathway; Longevity regulating pathway; PI3K-Akt signaling pathway	0
High	Q06265	Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3	0.004	2.265	3	1	2	1	439	48.9	5.29	1	1			1	1			201797.4375	201541.0938	209904.7656	190347.4688	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;protein binding;RNA binding	"Pf01138, Pf03725"	5393	ENSG00000123737.12	EXOSC9	4	"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA"	RNA degradation	0
High	Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Homo sapiens OX=9606 GN=BAIAP2L1 PE=1 SV=2	0.004	2.327	4	2	2	2	511	56.8	8.68	2				2				300585.7656	107884.5703	119889	217950.9531	2	1	1	1		cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	protein binding	"Pf00018, Pf07653, Pf08397, Pf14604"	55971	ENSG00000006453.13	BAIAP2L1	7			0
High	P60059	Protein transport protein Sec61 subunit gamma OS=Homo sapiens OX=9606 GN=SEC61G PE=1 SV=1	0	4.256	18	1	2	1	68	7.7	9.99			1	1			1	1	60811.82813	100551.6641	366376.625	413708.1875	1	1	1	1	Acetyl [N-Term]	transport	cytosol;endoplasmic reticulum;membrane	protein binding;transporter activity	Pf00584	23480	ENSG00000132432.13	SEC61G	7	ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane	Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection	0
Medium	Q9Y2R5	"28S ribosomal protein S17, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1"	0.019	1.575	7	1	2	1	130	14.5	9.85			1	1			1	1	291370.0625	361492.75	408371.8438	449903.2188	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	RNA binding;structural molecule activity	Pf00366	51373	ENSG00000239789.5	MRPS17	7	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination	Ribosome	0
High	Q8IW92	Beta-galactosidase-1-like protein 2 OS=Homo sapiens OX=9606 GN=GLB1L2 PE=1 SV=1	0.003	2.439	5	2	2	2	636	72	7.62				2				2				821472.2188				2		metabolic process	extracellular;vacuole	catalytic activity	"Pf01301, Pf02449"	89944	ENSG00000149328.14	GLB1L2	11			0
Low	Q12789	General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4	0.051	1.1	1	1	2	1	2109	238.7	7.3	1			1	1			1	143904.9688	57621.32031	78051.27344	121676.4609	1	1	1	1		metabolic process;regulation of biological process	membrane;nucleus	DNA binding;protein binding	Pf04182	2975	ENSG00000077235.17	GTF3C1	16	RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter		0
High	Q9Y5Q8	General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2	0	5.242	4	1	1	1	519	59.5	6.9	1				1				255555.2656				1				Met-loss+Acetyl [N-Term]	cell differentiation;cell organization and biogenesis;metabolic process	nucleus	DNA binding;protein binding	Pf09734	9328	ENSG00000148308.17	GTF3C5	9	RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter		0
High	Q5T7M9	Divergent protein kinase domain 1A OS=Homo sapiens OX=9606 GN=DIPK1A PE=2 SV=1	0.001	3.107	2	1	1	1	428	49	7.17				1				1				341290.9063				1			endoplasmic reticulum;membrane		"Pf12260, Pf14875"	388650	ENSG00000154511.11	FAM69A	1			0
High	P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4	0	6.23	3	1	1	1	589	65.3	5.11			1				1		83008.21094		1193763.75	358892.5938	1		1	1		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus	catalytic activity;enzyme regulator activity;protein binding	"Pf02985, Pf13513, Pf13646"	5518	ENSG00000105568.17	PPP2R1A	19	"Glycolysis; Regulation of PLK1 Activity at G2/M Transition; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; AURKA Activation by TPX2; S33 mutants of beta-catenin aren't phosphorylated; Anchoring of the basal body to the plasma membrane; S45 mutants of beta-catenin aren't phosphorylated; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of mitotic centrosome proteins and complexes; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; Initiation of Nuclear Envelope Reformation; Loss of Nlp from mitotic centrosomes; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex"	Dopaminergic synapse; Chagas disease (American trypanosomiasis); TGF-beta signaling pathway; Tight junction; Hippo signaling pathway; Adrenergic signaling in cardiomyocytes; AMPK signaling pathway; Long-term depression; mRNA surveillance pathway; Oocyte meiosis; Sphingolipid signaling pathway; Hepatitis C; PI3K-Akt signaling pathway	0
Medium	P53597	"Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4"	0.037	1.239	4	1	1	1	346	36.2	8.79				1				1										metabolic process	cytosol;membrane;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;RNA binding	"Pf00549, Pf02629, Pf13607"	8802	ENSG00000163541.11	SUCLG1	2	Citric acid cycle (TCA cycle)	Propanoate metabolism; Citrate cycle (TCA cycle); Carbon metabolism; Metabolic pathways	0
High	Q13586	Stromal interaction molecule 1 OS=Homo sapiens OX=9606 GN=STIM1 PE=1 SV=3	0.004	2.335	2	1	1	1	685	77.4	6.67			1				1											cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;endoplasmic reticulum;membrane	metal ion binding;protein binding;transporter activity	"Pf00430, Pf00769, Pf04111, Pf07647"	6786	ENSG00000167323.11	STIM1	11	Ion homeostasis; Elevation of cytosolic Ca2+ levels; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Calcium signaling pathway; Platelet activation	0
High	Q13547	Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1	0.004	2.274	4	1	1	1	482	55.1	5.48				1				1	400847.7188	223783.7969	443242.0313	594796.5625	1	1	1	1		cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding	Pf00850	3065	ENSG00000116478.11	HDAC1	1	NOTCH1 Intracellular Domain Regulates Transcription; NoRC negatively regulates rRNA expression; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Factors involved in megakaryocyte development and platelet production; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Activation of E2F1 target genes at G1/S; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Transcription of E2F targets under negative control by DREAM complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of TP53 Activity through Acetylation; Repression of WNT target genes; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; SUMOylation of chromatin organization proteins; Deactivation of the beta-catenin transactivating complex; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; p75NTR negatively regulates cell cycle via SC1; Signalling by NGF; RNA Polymerase I Transcription Initiation	Viral carcinogenesis; Longevity regulating pathway - multiple species; MicroRNAs in cancer; Amphetamine addiction; Chronic myeloid leukemia; Epstein-Barr virus infection; Huntington's disease; Pathways in cancer; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer; Notch signaling pathway; Alcoholism; Cell cycle	0
Medium	Q8N653	Leucine-zipper-like transcriptional regulator 1 OS=Homo sapiens OX=9606 GN=LZTR1 PE=1 SV=2	0.015	1.695	2	1	1	1	840	94.7	6.57	1				1				202163.3281				1					regulation of biological process	Golgi	protein binding	"Pf00651, Pf01344, Pf07646, Pf13415, Pf13418, Pf13854, Pf13964"	8216	ENSG00000099949.18	LZTR1	22			0
Medium	Q6P1Q9	tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3	0.015	1.673	3	1	1	1	378	43.4	5.86			1				1			74224.20313	99598.64844	116594.3672		1	1	1		metabolic process		catalytic activity	"Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847"	55798	ENSG00000165055.15	METTL2B	7			0
Medium	Q92611	ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Homo sapiens OX=9606 GN=EDEM1 PE=1 SV=1	0.041	1.203	1	1	1	1	657	73.7	6.92			1				1				418444.0938	575192.5625			1	1		metabolic process;response to stimulus	endoplasmic reticulum;membrane	catalytic activity;metal ion binding;protein binding	"Pf01175, Pf01532"	9695	ENSG00000134109.10	EDEM1	3	ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes	Protein processing in endoplasmic reticulum	0
High	P33991	DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5	0.003	2.524	1	1	1	1	863	96.5	6.74			1				1											metabolic process	membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00493, Pf07728, Pf14551"	4173	ENSG00000104738.16	MCM4	8	M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins	DNA replication; Cell cycle	0
Medium	Q14839	Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2	0.035	1.288	1	1	1	1	1912	217.9	5.86		1				1			56841.80859	128069.9297	125686.6641		1	1	1			cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytoskeleton;membrane;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf00176, Pf00271, Pf00385, Pf00628, Pf04851, Pf06461, Pf06465, Pf08073, Pf08074, Pf13831"	1108	ENSG00000111642.14	CHD4	12	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation	Viral carcinogenesis	0
Medium	P62826	GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3	0.011	1.736	6	1	1	1	216	24.4	7.49				1				1	701932.875	815070.3125	756840.4375	947476.625	1	1	1	1	Met-loss+Acetyl [N-Term]	cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytosol;endosome;membrane;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;transporter activity	"Pf00025, Pf00071, Pf08477"	5901	ENSG00000132341.11	RAN	12	MicroRNA (miRNA) biogenesis; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs	Epstein-Barr virus infection; Ribosome biogenesis in eukaryotes; HTLV-I infection; RNA transport	0
Medium	Q6Y7W6	GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1	0.024	1.403	1	1	1	1	1299	150	5.54	1				1				280049.6563	169781.7031			1	1				cell differentiation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane	protein binding;RNA binding	Pf02213	26058	ENSG00000204120.14	GIGYF2	2			0
Medium	O75717	WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1	0.011	1.823	1	1	1	1	1129	125.9	5.62	1				1				151632.25				1						cytoplasm;nucleus	DNA binding;protein binding	"Pf00400, Pf00505, Pf08662"	11169	ENSG00000198554.11	WDHD1	14			0
Medium	P28799	Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2	0.022	1.469	2	1	1	1	593	63.5	6.83				1				1		262553.4688	424274.2813	356957.9688		1	1	1		regulation of biological process;response to stimulus;transport	endoplasmic reticulum;endosome;extracellular;organelle lumen;vacuole	protein binding;RNA binding	Pf00396	2896	ENSG00000030582.17	GRN	17	Neutrophil degranulation		0
Low	Q9Y663	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Homo sapiens OX=9606 GN=HS3ST3A1 PE=1 SV=1	0.051	1.1	3	1	1	1	406	44.9	9.5				1				1		564026.4375	567313.9375	780275.875		1	1	1		metabolic process	Golgi;membrane	catalytic activity	Pf00685	9955	ENSG00000153976.2	HS3ST3A1	17	HS-GAG biosynthesis	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0
High	Q5BLP8	Neuropeptide-like protein C4orf48 OS=Homo sapiens OX=9606 GN=C4orf48 PE=1 SV=3	0.006	1.979	11	1	1	1	95	10.2	8.31				1				1				1139212.125				1			extracellular		Pf15161	401115	ENSG00000243449.6	C4orf48	4			0
High	Q9H813	Transmembrane protein 206 OS=Homo sapiens OX=9606 GN=TMEM206 PE=1 SV=1	0.004	2.247	3	1	1	1	350	40	8.88				1				1				609604.9375				1			cell surface;membrane		Pf15122	55248	ENSG00000065600.12	TMEM206	1			0
Medium	Q9GZU3	Transmembrane protein 39B OS=Homo sapiens OX=9606 GN=TMEM39B PE=1 SV=1	0.04	1.214	5	1	1	1	492	56.2	9.41			1				1				350465.0938	165506.4219			1	1			membrane		Pf10271	55116	ENSG00000121775.17	TMEM39B	1			0
Medium	Q9Y259	Choline/ethanolamine kinase OS=Homo sapiens OX=9606 GN=CHKB PE=1 SV=3	0.038	1.227	5	1	1	1	395	45.2	5.49			1				1		445823	602335.0625	666852.625	1241313.75	1	1	1	1	Met-loss+Acetyl [N-Term]	metabolic process	cytosol	catalytic activity;nucleotide binding	"Pf01633, Pf01636"	1120	ENSG00000100288.19	CHKB	22	Synthesis of PC; Synthesis of PE	Choline metabolism in cancer; Glycerophospholipid metabolism; Metabolic pathways	0
Medium	Q96F44	E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2	0.016	1.651	3	1	1	1	468	52.7	5.69				1				1	108243.6172	252538.4063	86853.61719	271054.5938	1	1	1	1		defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227"	81559	ENSG00000154370.15	TRIM11	1	Antigen processing: Ubiquitination & Proteasome degradation		0
Medium	Q9NZN8	CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1	0.022	1.477	1	1	1	1	540	59.7	7.66	1				1				221275.9531	77722.89063	66937.92969	111356.5859	1	1	1	1		cell differentiation;development;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;protein binding	Pf04153	4848	ENSG00000111596.11	CNOT2	12	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA	RNA degradation	0
Low	P55268	Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2	0.051	1.105	1	1	1	1	1798	195.9	6.52			1				1											cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytoplasm;extracellular;Golgi;organelle lumen	catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity	"Pf00053, Pf00055, Pf00430, Pf00769, Pf01576, Pf02050, Pf02841, Pf04111, Pf06008, Pf09831, Pf12128, Pf12795, Pf13514, Pf13851, Pf13868, Pf15070, Pf15558"	3913	ENSG00000172037.13	LAMB2	3	ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions	Amoebiasis; Pathways in cancer; Toxoplasmosis; Focal adhesion; Small cell lung cancer; ECM-receptor interaction; PI3K-Akt signaling pathway	0
High	Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2	0.003	2.458	2	1	1	1	626	72.2	7.14				1				1		63087.77734	66352.09375	138879.4375		1	1	1		cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding	"Pf00536, Pf01966, Pf07647"	25939	ENSG00000101347.8	SAMHD1	20	Nucleobase catabolism; Interferon alpha/beta signaling		0
Medium	P53618	Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3	0.021	1.494	1	1	1	1	953	107.1	6.05			1				1											transport	cytoplasm;cytosol;Golgi;membrane	protein binding;structural molecule activity	"Pf01602, Pf07718, Pf14806"	1315	ENSG00000129083.12	COPB1	11	COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport		0
High	Q9Y2G5	GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3	0.001	2.899	3	1	1	1	429	49.9	6.6				1				1			51401.73438	288066.1563			1	1		metabolic process;regulation of biological process	endoplasmic reticulum;Golgi;membrane	catalytic activity	Pf10250	23275	ENSG00000186866.16	POFUT2	21	O-glycosylation of TSR domain-containing proteins	Other types of O-glycan biosynthesis	0
Medium	O95613	Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4	0.023	1.415	0	1	1	1	3336	377.8	5.55	1				1				264232.5625				1					cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	catalytic activity;motor activity;protein binding;structural molecule activity	"Pf01576, Pf09726, Pf09731, Pf10495"	5116	ENSG00000160299.16	PCNT	21	Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes		0
High	Q9BZE1	"39S ribosomal protein L37, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2"	0.001	3.145	4	1	1	1	423	48.1	8.59				1				1	131214.3906	116594.9609	264529.3125	610642	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	RNA binding;structural molecule activity	Pf07147	51253	ENSG00000116221.15	MRPL37	1	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination		0
Medium	Q14566	DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1	0.015	1.695	1	1	1	1	821	92.8	5.41			1				1			99882.19531	224456.0781	99694.89844		1	1	1		metabolic process	nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00493, Pf01078, Pf07728, Pf14551"	4175	ENSG00000076003.4	MCM6	2	M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins	DNA replication; Cell cycle	0
Medium	Q16891	MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1	0.022	1.459	2	1	1	1	758	83.6	6.48				1				1	239842.6719		377761.2813	317967.9375	1		1	1		cell organization and biogenesis;cellular homeostasis	membrane;mitochondrion	protein binding;RNA binding	Pf09731	10989	ENSG00000132305.20	IMMT	2	Cristae formation		0
Medium	O14638	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Homo sapiens OX=9606 GN=ENPP3 PE=1 SV=2	0.042	1.166	1	1	1	1	875	100.1	6.57				1				1			441148.2813	7450907			1	1		metabolic process;response to stimulus;transport	extracellular;membrane	catalytic activity;metal ion binding;receptor activity	"Pf01033, Pf01223, Pf01663, Pf01676"	5169	ENSG00000154269.14	ENPP3	6	Vitamin B5 (pantothenate) metabolism	Purine metabolism; Pantothenate and CoA biosynthesis; Starch and sucrose metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways; Pyrimidine metabolism	0
Medium	Q9UNS2	COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3	0.048	1.117	3	1	1	1	423	47.8	6.65	1				1				91932.05469		143389.0625	96752.84375	1		1	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	protein binding	Pf01399	8533	ENSG00000141030.12	COPS3	17	Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation		0
Medium	P60604	Ubiquitin-conjugating enzyme E2 G2 OS=Homo sapiens OX=9606 GN=UBE2G2 PE=1 SV=1	0.021	1.527	9	1	1	1	165	18.6	4.7				1				1										metabolic process;response to stimulus	cytosol;endoplasmic reticulum	catalytic activity;nucleotide binding;protein binding	Pf00179	7327	ENSG00000184787.18	UBE2G2	21	Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation	Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson's disease	0
Medium	P23528	Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3	0.018	1.594	7	1	1	1	166	18.5	8.09			1				1		226532.1719	331356.2188	536643.25	547414.5	1	1	1	1		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	protein binding	Pf00241	1072	ENSG00000172757.12	CFL1	11	Platelet degranulation ; Sema3A PAK dependent Axon repulsion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Interleukin-12 family signaling	Pertussis; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Axon guidance	0
Medium	Q16695	Histone H3.1t OS=Homo sapiens OX=9606 GN=H3-4 PE=1 SV=3	0.022	1.481	7	1	1	1	136	15.5	11.12		1				1				2307775.75	1584321.875	1771790.5		1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	DNA binding;protein binding	Pf00125	8290	ENSG00000168148.3	HIST3H3	1	G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Nonhomologous End-Joining (NHEJ); Meiotic synapsis; Condensation of Prophase Chromosomes; Meiotic recombination; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of the beta-catenin:TCF transactivating complex; DNA Damage/Telomere Stress Induced Senescence	Transcriptional misregulation in cancer; Systemic lupus erythematosus; Alcoholism	0
Medium	Q9Y3B9	RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2	0.041	1.199	4	1	1	1	282	31.5	5.52			1				1		160177.625	77138.05469	270646.4688	276941.4375	1	1	1	1		metabolic process			Pf07890	51018	ENSG00000067533.5	RRP15	1			0
Low	Q9HBH1	"Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1"	0.057	0.988	3	1	1	1	243	27	9.16				1				1	36814.67578			378139.875	1			1		metabolic process;regulation of biological process	mitochondrion	catalytic activity;metal ion binding	Pf01327	64146	ENSG00000258429.1	PDF	16			0
Medium	P78346	Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1	0.028	1.394	4	1	1	1	268	29.3	8.91			1				1		100717.2734	77781.23438	189865.7344	348486.1875	1	1	1	1	Met-loss+Acetyl [N-Term]	metabolic process	nucleus	catalytic activity;protein binding;RNA binding	Pf01876	10556	ENSG00000148688.13	RPP30	10	Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus	Ribosome biogenesis in eukaryotes; RNA transport	0
Medium	O14578	Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2	0.021	1.492	1	1	1	1	2027	231.3	6.57	1				1				182509.2188	59988.03125		132413.0313	1	1		1		cell death;cell differentiation;cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane	catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity	"Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00780, Pf01496, Pf01576, Pf01636, Pf02463, Pf03962, Pf04111, Pf04156, Pf05557, Pf05622, Pf05667, Pf07714, Pf07888, Pf07926, Pf08614, Pf10174, Pf12128, Pf14531"	11113	ENSG00000122966.15	CIT	12	RHO GTPases activate CIT		0
Medium	Q9UKX7	Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2	0.042	1.17	3	1	1	1	468	50.1	7.06	1				1				363682.4063		70382.79688		1		1			cell organization and biogenesis;metabolic process;regulation of biological process;transport	membrane;nucleus	protein binding	"Pf00638, Pf08911"	10762	ENSG00000093000.18	NUP50	22	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	Q9NSE4	"Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2"	0.005	2.067	2	1	1	1	1012	113.7	7.2				1				1										metabolic process;regulation of biological process	cytoplasm;cytosol;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;RNA binding	"Pf00133, Pf06827, Pf08264, Pf09334, Pf13603"	55699	ENSG00000067704.9	IARS2	1	Mitochondrial tRNA aminoacylation	Aminoacyl-tRNA biosynthesis	0
Medium	Q9BZE4	Nucleolar GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP4 PE=1 SV=3	0.03	1.345	1	1	1	1	634	73.9	9.5			1				1		86389.78906	50545.53906	157730.4375	134320.8438	1	1	1	1		cell differentiation;regulation of biological process;response to stimulus	cytoplasm;cytosol;Golgi;membrane;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00009, Pf01926, Pf02421, Pf06858, Pf08155, Pf08477"	23560	ENSG00000107937.18	GTPBP4	10		Ribosome biogenesis in eukaryotes	0
Medium	P62995	Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1	0.022	1.43	6	1	1	1	288	33.6	11.25	1				1													cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	membrane;nucleus;spliceosomal complex	protein binding;RNA binding	"Pf00076, Pf08777, Pf13893, Pf14259"	6434	ENSG00000136527.17	TRA2B	3	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q02413	Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2	0.005	2.035	2	1	1	1	1049	113.7	5.03		1				1			465735.625	563985.6875	284618.7188	490123.5313	1	1	1	1		cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoskeleton;cytosol;membrane	metal ion binding;protein binding	"Pf00028, Pf01049"	1828	ENSG00000134760.5	DSG1	18	Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation	Staphylococcus aureus infection	0
High	P13667	Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2	0.001	2.865	2	1	1	1	645	72.9	5.07				1				1	81384			358009.3125	1			1		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;organelle lumen	catalytic activity;metal ion binding;protein binding;RNA binding	"Pf00085, Pf01216, Pf13098, Pf13848, Pf13905"	9601	ENSG00000155660.10	PDIA4	7		Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Vibrio cholerae infection	0
High	Q08AM6	Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1	0.002	2.601	2	1	1	1	782	87.9	6.13	1				1													metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;endosome;membrane	protein binding;receptor activity	"Pf11916, Pf12755"	55697	ENSG00000103043.14	VAC14	16	Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane	Viral carcinogenesis; HTLV-I infection	0
Medium	C9JLW8	Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1	0.037	1.24	9	1	1	1	97	10.9	9.41	1				1				201779.4531	133154.5781	240178.5313	213400.7031	1	1	1	1		regulation of biological process	cytoplasm;nucleus	protein binding	Pf14799	348262	ENSG00000225663.7	FAM195B; MCRIP1	17			0
High	Q6WKZ4	Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3	0.001	2.954	1	1	1	1	1283	137.1	5.43			1				1											regulation of biological process;transport	cytoplasm;cytosol;endosome;membrane	protein binding	"Pf00168, Pf09457"	80223	ENSG00000156675.15	RAB11FIP1	8		Endocytosis	0
Low	Q9BTE3	Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2	0.059	0.964	2	1	1	1	642	72.9	5.87				1				1	97588.69531	111869.2031	122603.2031	124833.0469	1	1	1	1		cell division;cell organization and biogenesis;metabolic process	cytosol;membrane;nucleus	protein binding	"Pf09739, Pf13615"	79892	ENSG00000197771.12	MCMBP	10			0
Medium	Q9Y3B7	"39S ribosomal protein L11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1"	0.019	1.58	6	1	1	1	192	20.7	9.91				1				1	107228.125	149798.8438	350537.625	246112.4219	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	protein binding;RNA binding;structural molecule activity	"Pf00298, Pf03946"	65003	ENSG00000174547.13	MRPL11	11	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination	Ribosome	0
Low	Q9UMR5	Lysosomal thioesterase PPT2 OS=Homo sapiens OX=9606 GN=PPT2 PE=1 SV=4	0.056	1.013	3	1	1	1	302	34.2	6.33				1				1				562016.6875				1		metabolic process	organelle lumen;vacuole	catalytic activity	"Pf00561, Pf02089, Pf12697"	9374	ENSG00000221988.12	PPT2	6	Fatty acyl-CoA biosynthesis	Lysosome; Fatty acid elongation; Metabolic pathways; Fatty acid metabolism	0
Medium	Q9H840	Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1	0.021	1.49	10	1	1	1	131	14.5	7.4	1				1				299586.75				1				Acetyl [N-Term]	cell organization and biogenesis;metabolic process;transport	cytoplasm;cytosol;nucleus	protein binding	Pf11095	79760	ENSG00000142252.10	GEMIN7	19	snRNP Assembly	RNA transport	0
Medium	Q86VP6	Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2	0.011	1.734	1	1	1	1	1230	136.3	5.78			1				1		30212.88281	66627.96875	100343.1172	99276.03906	1	1	1	1		cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen	protein binding	"Pf08623, Pf12755, Pf13513"	55832	ENSG00000111530.12	CAND1	12	Neutrophil degranulation; Iron uptake and transport; Neddylation		0
Medium	P53803	"DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1"	0.039	1.219	12	1	1	1	58	7	9.06			1				1		96843.29688	73918.95313	143770.7344	142145.3281	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;DNA binding;metal ion binding	Pf03604	5440	ENSG00000147669.10	POLR2K	8	Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter	Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism	0
Medium	O00767	Acyl-CoA desaturase OS=Homo sapiens OX=9606 GN=SCD PE=1 SV=2	0.044	1.139	4	1	1	1	359	41.5	9				1				1		584868.3125	432173.0938	1166859.875		1	1	1		metabolic process;regulation of biological process	endoplasmic reticulum;membrane	catalytic activity;metal ion binding	Pf00487	6319	ENSG00000099194.5	SCD	10	Fatty acyl-CoA biosynthesis; Activation of gene expression by SREBF (SREBP)	PPAR signaling pathway; AMPK signaling pathway; Biosynthesis of unsaturated fatty acids; Fatty acid metabolism	0
High	Q6NT76	Homeobox-containing protein 1 OS=Homo sapiens OX=9606 GN=HMBOX1 PE=1 SV=1	0.002	2.623	4	1	1	1	420	47.2	6.06		1				1												metabolic process;regulation of biological process	cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;protein binding	"Pf00046, Pf04814"	79618	ENSG00000147421.17	HMBOX1	8			0
Medium	Q9Y520	Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4	0.028	1.377	1	1	1	1	2896	316.7	9.13	1				1				250763.9375	345734.3438		352878.8438	1	1		1		cell differentiation	membrane	protein binding;RNA binding	Pf07001	23215		PRRC2C	1			0
High	O14513	Nck-associated protein 5 OS=Homo sapiens OX=9606 GN=NCKAP5 PE=1 SV=2	0.006	1.949	2	1	1	1	1909	208.4	8.07				1				1		452976.5938		708553.8125		1		1					Pf15246	344148	ENSG00000176771.16	NCKAP5	2			0
Medium	P33947	ER lumen protein-retaining receptor 2 OS=Homo sapiens OX=9606 GN=KDELR2 PE=1 SV=1	0.011	1.759	4	1	1	1	212	24.4	8.72			1				1											transport	endoplasmic reticulum;Golgi;membrane		Pf00810	11014	ENSG00000136240.9	KDELR2	7	COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport	Vibrio cholerae infection	0
High	P12270	Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3	0.004	2.276	0	1	1	1	2363	267.1	5.02	1				1				117119.2344	112973.7578	134783.8438	276084.4063	1	1	1	1		cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	chromosome;cytoplasm;cytoskeleton;membrane;nucleus	catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity;transporter activity	"Pf00038, Pf01496, Pf01576, Pf02463, Pf03961, Pf04111, Pf05911, Pf07888, Pf07926, Pf09726, Pf12128, Pf13166, Pf13514"	7175	ENSG00000047410.13	TPR	1	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	Pathways in cancer; RNA transport; Thyroid cancer	0
Medium	Q32P28	Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2	0.015	1.67	1	1	1	1	736	83.3	5.14				1				1				910970.25				1		metabolic process;regulation of biological process	endoplasmic reticulum;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	Pf13640	64175	ENSG00000117385.15	LEPRE1; P3H1	1	Collagen biosynthesis and modifying enzymes		0
Medium	O75586	Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2	0.022	1.48	6	1	1	1	246	28.4	8.62				1				1			217649.625	274987.6563			1	1		cell organization and biogenesis;metabolic process;regulation of biological process	membrane;nucleus	protein binding	Pf04934	10001	ENSG00000133997.11	MED6	14	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway		0
Medium	Q8NE01	Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1	0.042	1.153	1	1	1	1	707	76.1	6.09				1				1			207814.5781	1462237.75			1	1		transport	membrane	protein binding	Pf00571	26505	ENSG00000168763.15	CNNM3	2			0
High	P62195	26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1	0.004	2.309	4	1	1	1	406	45.6	7.55			1				1				290314.7188				1			metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401"	5705	ENSG00000087191.12	PSMC5	17	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Epstein-Barr virus infection; Proteasome	0
High	Q01658	Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1	0.002	2.657	7	1	1	1	176	19.4	4.75		1				1												cell organization and biogenesis;metabolic process;regulation of biological process	nucleus	DNA binding;protein binding	Pf00808	1810	ENSG00000117505.12	DR1	1	HATs acetylate histones		0
Low	A6NFN3	RNA binding protein fox-1 homolog 3 OS=Homo sapiens OX=9606 GN=RBFOX3 PE=2 SV=4	0.056	1.018	3	1	1	1	312	33.9	7.27				1				1	40937.59375	38983.28906	92052.69531	201648.5156	1	1	1	1		metabolic process;regulation of biological process	cytoplasm;nucleus	DNA binding;RNA binding	"Pf00076, Pf08777, Pf12414, Pf13893, Pf14259"	146713	ENSG00000167281.18	RBFOX3	17			0
High	O95801	Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3	0.005	2.044	3	1	1	1	387	44.7	5.6				1				1				221362.6563				1				protein binding	"Pf13414, Pf13432"	7268	ENSG00000243725.6	TTC4	1			0
High	Q6ZW49	PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2	0.003	2.401	1	1	1	1	1069	121.3	6.7			1				1			218858.375	371672.625			1	1			cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	protein binding	"Pf00533, Pf12738"	22976	ENSG00000157212.18	PAXIP1	7	Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis		0
Low	Q16348	Solute carrier family 15 member 2 OS=Homo sapiens OX=9606 GN=SLC15A2 PE=1 SV=2	0.057	0.991	4	1	1	1	729	81.7	8.16				1				1										transport	membrane	protein binding;transporter activity	Pf00854	6565	ENSG00000163406.10	SLC15A2	3	Proton/oligopeptide cotransporters		0
High	Q6P1M0	Long-chain fatty acid transport protein 4 OS=Homo sapiens OX=9606 GN=SLC27A4 PE=1 SV=1	0.004	2.229	2	1	1	1	643	72	8.47				1				1		54569.42969	132820.625	278525.3125		1	1	1		metabolic process;response to stimulus;transport	endoplasmic reticulum;membrane	catalytic activity;nucleotide binding;transporter activity	"Pf00501, Pf13193"	10999	ENSG00000167114.12	SLC27A4	9	Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS); Transport of fatty acids	Fat digestion and absorption; PPAR signaling pathway; Insulin resistance	0
Low	P21796	Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2	0.051	1.107	4	1	1	1	283	30.8	8.54				1				1				251847.1094				1		cell communication;cell death;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	membrane;mitochondrion;nucleus	protein binding;transporter activity	Pf01459	7416	ENSG00000213585.10	VDAC1	5	Mitochondrial calcium ion transport; Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy	NOD-like receptor signaling pathway; cGMP-PKG signaling pathway; Huntington's disease; HTLV-I infection; Parkinson's disease; Influenza A; Calcium signaling pathway	0
High	P01031	Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4	0.006	1.962	1	1	1	1	1676	188.2	6.52				1				1		153544.9063	254200.9531	245166.1719		1	1	1		cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;protein binding	"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf11974"	727	ENSG00000106804.7	C5	9	Terminal pathway of complement; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; G alpha (i) signalling events	Prion diseases; Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Herpes simplex infection; Staphylococcus aureus infection	0
Medium	Q14203	Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3	0.021	1.511	1	1	1	1	1278	141.6	5.81	1				1				119383.3203	179454.4375			1	1				cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;motor activity;protein binding	"Pf00261, Pf01302, Pf04111, Pf05622, Pf05667, Pf06160, Pf08317, Pf12128, Pf12329, Pf12455, Pf13166, Pf13514, Pf15035"	1639	ENSG00000204843.12	DCTN1	2	COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; XBP1(S) activates chaperone genes; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR)	Huntington's disease; Vasopressin-regulated water reabsorption	0
High	Q1KMD3	Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1	0.004	2.125	1	1	1	1	747	85.1	4.91		1				1			310348.5625	751464.8125	202019.8125		1	1	1				membrane;nucleus	protein binding;RNA binding	"Pf00622, Pf02037, Pf08433, Pf13671"	221092	ENSG00000214753.2	HNRNPUL2	11			0
Medium	P05165	"Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4"	0.011	1.774	1	1	1	1	728	80	7.52				1				1	44007.79297		255626.1094	310801.6875	1		1	1		metabolic process	cytosol;extracellular;mitochondrion;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00289, Pf00364, Pf01071, Pf02222, Pf02258, Pf02785, Pf02786, Pf07478, Pf08442, Pf08443, Pf13437, Pf13533, Pf13535, Pf13549, Pf15632"	5095	ENSG00000175198.15	PCCA	13	Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism	"Propanoate metabolism; Carbon metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Valine, leucine and isoleucine degradation"	0
Medium	O95782	AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3	0.011	1.744	1	1	1	1	977	107.5	7.03			1				1		4191987.5	3285183.75	3307070.5	3903557.75	1	1	1	1		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;membrane	protein binding;transporter activity	"Pf01602, Pf02296, Pf02883, Pf13646"	160	ENSG00000196961.12	AP2A1	19	"Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4"	Endocytosis; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle	0
High	Q53S58	Transmembrane protein 177 OS=Homo sapiens OX=9606 GN=TMEM177 PE=1 SV=1	0.005	1.992	3	1	1	1	311	33.7	9.61				1				1			252010.7969	395307.5938			1	1			membrane			80775	ENSG00000144120.12	TMEM177	2			0
High	Q9NS84	Carbohydrate sulfotransferase 7 OS=Homo sapiens OX=9606 GN=CHST7 PE=1 SV=2	0.003	2.552	2	1	1	1	486	54.2	9.64				1				1			88411.75	134375.0313			1	1		metabolic process	Golgi;membrane	catalytic activity		56548	ENSG00000147119.3	CHST7	X	Chondroitin sulfate biosynthesis	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0
High	Q4G0M1	Erythroferrone OS=Homo sapiens OX=9606 GN=ERFE PE=2 SV=2	0.006	1.942	2	1	1	1	354	37.3	9.83				1				1			50235.51172	248857.2813			1	1		cellular homeostasis;regulation of biological process	extracellular	protein binding		151176	ENSG00000178752.15	FAM132B; ERFE	2			0
High	P02747	Complement C1q subcomponent subunit C OS=Homo sapiens OX=9606 GN=C1QC PE=1 SV=3	0.001	3.076	7	1	1	1	245	25.8	8.41				1				1		1736468.375	1865035.75	1547750.375		1	1	1		defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	"Pf00229, Pf00386"	714	ENSG00000159189.11	C1QC	1	Regulation of Complement cascade; Classical antibody-mediated complement activation	Chagas disease (American trypanosomiasis); Prion diseases; Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus; Staphylococcus aureus infection	0
High	Q9Y221	60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1	0.005	2.047	11	1	1	1	180	20.4	8.51			1				1											cell organization and biogenesis	cytosol;nucleus	protein binding;RNA binding	Pf03657	51388	ENSG00000132603.13	NIP7	16	Major pathway of rRNA processing in the nucleolus and cytosol		0
Low	Q7L8J4	SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1	0.051	1.096	2	1	1	1	393	43.5	5.77			1				1		27477426	16429084	21157174	22077984	1	1	1	1		regulation of biological process;response to stimulus	cytoplasm	enzyme regulator activity;protein binding	Pf05276	80851	ENSG00000175137.10	SH3BP5L	1			0
Medium	Q9P0B6	Coiled-coil domain-containing protein 167 OS=Homo sapiens OX=9606 GN=CCDC167 PE=1 SV=2	0.015	1.703	15	1	1	1	97	11.5	9.5				1				1											membrane		Pf15188	154467	ENSG00000198937.8	CCDC167	6			0
Low	Q8NHR7	Telomere repeats-binding bouquet formation protein 2 OS=Homo sapiens OX=9606 GN=TERB2 PE=1 SV=1	0.056	1.029	15	1	1	1	220	25.3	7.59				1				1			465492.7188	243143.1094			1	1		cell organization and biogenesis	chromosome;membrane;nucleus		Pf15101	145645	ENSG00000167014.10	C15orf43; TERB2	15			0
High	Q9P2X0	Dolichol-phosphate mannosyltransferase subunit 3 OS=Homo sapiens OX=9606 GN=DPM3 PE=1 SV=2	0.005	2.024	11	1	1	1	92	10.1	5.94				1				1			224979.9375	418509.0313			1	1		metabolic process;regulation of biological process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf08285	54344	ENSG00000179085.7	DPM3	1	Defective DPM3 causes DPM3-CDG (CDG-1o); Synthesis of dolichyl-phosphate mannose	N-Glycan biosynthesis; Metabolic pathways	0
Medium	Q8TEQ6	Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3	0.011	1.772	0	1	1	1	1508	168.5	6.62	1				1				100823.7891	66045.94531	103097.8281	61920.28516	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	Pf00400	25929	ENSG00000082516.8	GEMIN5	5	snRNP Assembly	RNA transport	0
Medium	Q9NSB4	"Keratin, type II cuticular Hb2 OS=Homo sapiens OX=9606 GN=KRT82 PE=1 SV=3"	0.041	1.191	1	1	1	1	513	56.6	6.74	1				1				12997449	15478492	9497433	15241541	1	1	1	1		cell death	cytosol	structural molecule activity	Pf00038	3888	ENSG00000161850.2	KRT82	12	Formation of the cornified envelope		0
Medium	Q9UKG1	DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1	0.022	1.441	2	1	1	1	709	79.6	5.41	1				1				266340.375				1					cell proliferation;regulation of biological process;response to stimulus	cytoplasm;cytosol;endosome;membrane;nucleus	protein binding	"Pf00169, Pf00640"	26060	ENSG00000157500.10	APPL1	3	Ligand-independent caspase activation via DCC	Colorectal cancer; Pathways in cancer; Longevity regulating pathway	0
Medium	Q6SJ96	TATA box-binding protein-like protein 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=1	0.022	1.471	2	1	1	1	375	41.5	6.43		1				1				740075.5625	683042.8125	296703.2188		1	1	1		development;metabolic process;regulation of biological process	cytoplasm;nucleus	DNA binding	Pf00352	387332	ENSG00000182521.5	TBPL2	14		Viral carcinogenesis; Basal transcription factors; Epstein-Barr virus infection; Huntington's disease; HTLV-I infection; Herpes simplex infection	0
Medium	Q53HC5	Kelch-like protein 26 OS=Homo sapiens OX=9606 GN=KLHL26 PE=1 SV=2	0.024	1.405	2	1	1	1	615	68.1	6.48	1				1				243474.0781	129584.2813		182293.0938	1	1		1		metabolic process	cytoplasm	catalytic activity;protein binding	"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964"	55295	ENSG00000167487.11	KLHL26	19			0
Low	Q96EL2	"28S ribosomal protein S24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS24 PE=1 SV=1"	0.058	0.977	5	1	1	1	167	19	9.38				1				1			78139.82813	138648.0469			1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	RNA binding;structural molecule activity	Pf14955	64951	ENSG00000062582.13	MRPS24	7	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination		0
High	Q9HAT2	Sialate O-acetylesterase OS=Homo sapiens OX=9606 GN=SIAE PE=1 SV=1	0.001	2.789	2	1	1	1	523	58.3	7.33				1				1			72936.64063	330919.0313			1	1		metabolic process;regulation of biological process	extracellular;vacuole	catalytic activity	Pf03629	54414	ENSG00000110013.12	SIAE	11			0
High	O75487	Glypican-4 OS=Homo sapiens OX=9606 GN=GPC4 PE=1 SV=4	0.001	3.229	3	1	1	1	556	62.4	6.68				1				1										cell proliferation;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane;nucleus;organelle lumen	protein binding	Pf01153	2239	ENSG00000076716.8	GPC4	X	"Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type; Retinoid metabolism and transport; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective EXT2 causes exostoses 2; Defective B3GAT3 causes JDSSDHD; Defective EXT1 causes exostoses 1, TRPS2 and CHDS"	Wnt signaling pathway	0
Medium	Q12996	Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1	0.011	1.773	2	1	1	1	717	82.9	8.12	1				1				347990.8438				1					metabolic process	nucleus	protein binding;RNA binding	Pf05843	1479	ENSG00000176102.11	CSTF3	11	Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway	mRNA surveillance pathway	0
Medium	Q9BQ75	Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2	0.016	1.653	7	1	1	1	279	31.9	9.19			1				1												nucleus	nucleotide binding;RNA binding	"Pf00270, Pf14617"	84319	ENSG00000184220.11	CMSS1	3			0
High	P09543	"2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2"	0.001	3.143	3	1	1	1	421	47.5	9.07				1				1		155797.3281	357802.7188	662221.4375		1	1	1		cell communication;cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus	cytoplasm;membrane	catalytic activity;nucleotide binding;RNA binding	"Pf01591, Pf05881, Pf08302, Pf13207, Pf13671"	1267	ENSG00000173786.16	CNP	17			0
Low	Q8IYH5	ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1	0.052	1.082	1	1	1	1	903	102	5.69			1				1			697149.375	805165.4375	771463.875		1	1	1		metabolic process;regulation of biological process	nucleus	DNA binding;metal ion binding;protein binding	"Pf00249, Pf00569"	26009	ENSG00000036549.12	ZZZ3	1	HATs acetylate histones		0
High	Q8NBN3	Transmembrane protein 87A OS=Homo sapiens OX=9606 GN=TMEM87A PE=1 SV=3	0.002	2.666	2	1	1	1	555	63.4	6.74				1				1			111697.8281	641898.75			1	1		transport	cytosol;Golgi;membrane		Pf06814	25963	ENSG00000103978.15	TMEM87A	15			0
High	Q99720	Sigma non-opioid intracellular receptor 1 OS=Homo sapiens OX=9606 GN=SIGMAR1 PE=1 SV=1	0	3.47	6	1	1	1	223	25.1	5.96				1				1				1344102.25				1		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane;nucleus	protein binding;receptor activity;signal transducer activity	Pf04622	10280	ENSG00000147955.16	SIGMAR1	9			0
Medium	Q9UH99	SUN domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUN2 PE=1 SV=3	0.039	1.223	3	1	1	1	717	80.3	6.73			1				1											cell organization and biogenesis;cellular component movement;regulation of biological process;transport	chromosome;endosome;membrane;nucleus	protein binding	Pf07738	25777	ENSG00000100242.15	SUN2	22	Meiotic synapsis		0
Medium	A1L188	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 OS=Homo sapiens OX=9606 GN=NDUFAF8 PE=1 SV=1	0.028	1.38	8	1	1	1	74	7.8	9.32			1				1				360374.4688	247879.9375			1	1		cell organization and biogenesis	mitochondrion	protein binding		284184	ENSG00000224877.3	C17orf89; NDUFAF8	17			0
High	Q13503	Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1	0.004	2.137	13	1	1	1	144	15.6	4.45			1				1			398515.9375	1677255.125	444194.1563		1	1	1		metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding	Pf11221	9412	ENSG00000152944.8	MED21	12	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression		0
Medium	Q6PID8	Kelch domain-containing protein 10 OS=Homo sapiens OX=9606 GN=KLHDC10 PE=1 SV=1	0.011	1.821	5	1	1	1	442	49.1	9.38	1				1														cytoplasm;nucleus	protein binding	"Pf01344, Pf07646, Pf13415, Pf13418, Pf13854, Pf13964"	23008	ENSG00000128607.13	KLHDC10	7			0
High	P13995	"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2"	0.004	2.166	6	1	1	1	350	37.9	8.73				1				1		274151.5313	287576.125	453229.7813		1	1	1		metabolic process	cytosol;mitochondrion;organelle lumen	catalytic activity;metal ion binding	"Pf00763, Pf02882"	10797	ENSG00000065911.11	MTHFD2	2	Metabolism of folate and pterines	One carbon pool by folate; Metabolic pathways	0
Medium	Q13257	Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1	0.022	1.476	3	1	1	1	205	23.5	5.08	1				1													cell division;cell organization and biogenesis;metabolic process;regulation of biological process	chromosome;cytoplasm;cytoskeleton;cytosol;nucleus	protein binding	Pf02301	4085	ENSG00000164109.13	MAD2L1	4	Inactivation of APC/C via direct inhibition of the APC/C complex; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A	Progesterone-mediated oocyte maturation; HTLV-I infection; Oocyte meiosis; Cell cycle	0
Medium	Q15058	Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1	0.012	1.723	0	1	1	1	1648	186.4	7.91	1				1				116735.8516	95975.11719	107341.5938	76916.42188	1	1	1	1		cell division;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding	"Pf00225, Pf00498, Pf00769, Pf01576, Pf02463, Pf02841, Pf05262, Pf05622, Pf09726, Pf09731, Pf11068, Pf11740, Pf12128, Pf13514, Pf13868"	9928	ENSG00000118193.11	KIF14	1	RHO GTPases activate CIT		0
Medium	Q9Y5B9	FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1	0.033	1.305	1	1	1	1	1047	119.8	5.66			1				1			466876.8125	232601.375	192575.6875		1	1	1	Met-loss+Acetyl [N-Term]	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;nucleus	protein binding;RNA binding	"Pf00557, Pf08512, Pf08644, Pf14826"	11198	ENSG00000092201.9	SUPT16H	14	HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat		0
Medium	P30532	Neuronal acetylcholine receptor subunit alpha-5 OS=Homo sapiens OX=9606 GN=CHRNA5 PE=1 SV=2	0.022	1.446	2	1	1	1	468	53	6.98				1				1				688476.5				1		cell communication;regulation of biological process;response to stimulus;transport	membrane	protein binding;receptor activity;signal transducer activity;transporter activity	"Pf02931, Pf02932"	1138	ENSG00000169684.13	CHRNA5	15	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors; Highly calcium permeable nicotinic acetylcholine receptors	Neuroactive ligand-receptor interaction	0
Medium	Q9H8J5	MANSC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MANSC1 PE=1 SV=1	0.041	1.19	9	1	1	1	431	46.8	6.54				1				1				252613.8594				1			membrane		Pf07502	54682	ENSG00000281818.2; ENSG00000111261.13	MANSC1	12; CHR_HG1362_PATCH			0
Medium	Q8WUY9	DEP domain-containing protein 1B OS=Homo sapiens OX=9606 GN=DEPDC1B PE=1 SV=2	0.039	1.221	3	1	1	1	529	61.7	8.85			1				1				88299.78906				1			cellular component movement;regulation of biological process;response to stimulus	cytosol	enzyme regulator activity	"Pf00610, Pf00620"	55789	ENSG00000035499.12	DEPDC1B	5	Rho GTPase cycle		0
High	Q8NDN9	RCC1 and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCBTB1 PE=1 SV=1	0	4	3	1	1	1	531	58.2	6.47		1				1			320494.6875	597099.875	218513.3906	360132.875	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;nucleus	protein binding	"Pf00415, Pf00651, Pf13540"	55213	ENSG00000136144.11	RCBTB1	13			0
High	P52209	"6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3"	0.001	2.702	2	1	1	1	483	53.1	7.23				1				1			53270.26953	350316.9688			1	1		metabolic process	cytoplasm;cytosol;nucleus	catalytic activity	"Pf00393, Pf03446"	5226	ENSG00000142657.20	PGD	1	Pentose phosphate pathway (hexose monophosphate shunt)	Carbon metabolism; Glutathione metabolism; Pentose phosphate pathway; Metabolic pathways	0
High	Q99943	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens OX=9606 GN=AGPAT1 PE=1 SV=2	0	4.282	7	1	1	1	283	31.7	9.38				1				1				284871.625				1		metabolic process;regulation of biological process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf01553	10554	ENSG00000235758.9; ENSG00000228892.9; ENSG00000227642.9; ENSG00000206324.11; ENSG00000204310.12; ENSG00000236873.9; ENSG00000226467.9	AGPAT1	6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_COX_CTG1	Synthesis of PA; ChREBP activates metabolic gene expression	Fat digestion and absorption; Phospholipase D signaling pathway; Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways	0
Medium	Q92782	Zinc finger protein neuro-d4 OS=Homo sapiens OX=9606 GN=DPF1 PE=1 SV=2	0.028	1.371	6	1	1	1	380	42.5	6.86	1				1													cell death;metabolic process;regulation of biological process	cytoplasm;nucleus	metal ion binding;protein binding	"Pf00628, Pf14051"	8193	ENSG00000011332.19	DPF1	19			0
High	Q9Y3Y2	Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2	0.002	2.635	5	1	1	1	248	26.4	12.23		1				1												metabolic process;regulation of biological process;transport	nucleus	DNA binding;nucleotide binding;protein binding;RNA binding	Pf13865	26097	ENSG00000160679.12	CHTOP	1	Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing		0
Medium	Q92614	Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3	0.022	1.461	1	1	1	1	2054	233	6.3			1				1		78560.25	166355.9844	286427.8125	202530.1563	1	1	1	1		cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cell surface;cytoplasm;cytoskeleton;Golgi;membrane	catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding;RNA binding;structural molecule activity;transporter activity	"Pf00038, Pf00063, Pf00595, Pf00769, Pf01496, Pf01576, Pf02463, Pf02841, Pf03962, Pf04111, Pf04156, Pf04502, Pf04615, Pf05483, Pf05557, Pf05622, Pf05701, Pf05911, Pf06008, Pf06160, Pf06785, Pf06818, Pf07111, Pf07888, Pf08286, Pf09726, Pf09728, Pf09731, Pf09789, Pf10174, Pf12128, Pf12252, Pf12718, Pf13514, Pf13851, Pf14643, Pf14662, Pf14992, Pf15066, Pf15070, Pf15397"	399687	ENSG00000196535.15	MYO18A	17	Signaling by cytosolic FGFR1 fusion mutants		0
Medium	P52907	F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3	0.031	1.329	6	1	1	1	286	32.9	5.69	1				1				287143.3438	123361.1172	148888.5469		1	1	1			cell organization and biogenesis;cellular component movement;coagulation;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular	protein binding	Pf01267	829	ENSG00000116489.12	CAPZA1	1	COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Advanced glycosylation endproduct receptor signaling; Factors involved in megakaryocyte development and platelet production; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Interleukin-12 family signaling	Endocytosis	0
Medium	P43251	Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2	0.023	1.412	3	1	1	1	543	61.1	6.25				1				1				417012				1		metabolic process	extracellular;organelle lumen	catalytic activity	Pf00795	686	ENSG00000169814.12	BTD	3	Defective BTD causes biotidinase deficiency; Biotin transport and metabolism	Vitamin digestion and absorption; Biotin metabolism; Metabolic pathways	0
High	P67812	Signal peptidase complex catalytic subunit SEC11A OS=Homo sapiens OX=9606 GN=SEC11A PE=1 SV=1	0.001	2.892	4	1	1	1	179	20.6	9.48				1				1				383746.25				1		metabolic process	endoplasmic reticulum;membrane	catalytic activity	Pf00717	23478	ENSG00000140612.13	SEC11A	15	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"	Protein export	0
Medium	Q9ULH1	"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4"	0.027	1.398	1	1	1	1	1129	125.4	7.31		1				1												cell organization and biogenesis;regulation of biological process	cytoplasm;cytosol;membrane	enzyme regulator activity;metal ion binding;protein binding	"Pf00018, Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857, Pf14604"	50807	ENSG00000153317.14	ASAP1	8	VxPx cargo-targeting to cilium	Endocytosis; Fc gamma R-mediated phagocytosis	0
High	O60232	Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1	0.001	3.253	9	1	1	1	199	21.5	5.24	1				1				546155.1875				1					cell division		protein binding	Pf06677	10534	ENSG00000173465.7	SSSCA1	11			0
Medium	Q14494	Endoplasmic reticulum membrane sensor NFE2L1 OS=Homo sapiens OX=9606 GN=NFE2L1 PE=1 SV=1	0.022	1.437	1	1	1	1	772	84.7	4.64				1				1				490377.5				1		cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus	DNA binding;protein binding	"Pf00170, Pf03131, Pf07716"	4779	ENSG00000082641.15	NFE2L1	17			0
Medium	P98153	Integral membrane protein DGCR2/IDD OS=Homo sapiens OX=9606 GN=DGCR2 PE=1 SV=1	0.021	1.503	1	1	1	1	550	60.8	5.3				1				1			119188.6016	209126.125			1	1			membrane	protein binding	"Pf00057, Pf00059"	9993	ENSG00000070413.19	DGCR2	22			0
Medium	Q15005	Signal peptidase complex subunit 2 OS=Homo sapiens OX=9606 GN=SPCS2 PE=1 SV=3	0.041	1.189	3	1	1	1	226	25	8.47				1				1										metabolic process;transport	endoplasmic reticulum;membrane	catalytic activity	Pf06703	9789	ENSG00000118363.11	SPCS2	11	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"	Protein export	0
High	Q9HCN8	Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2	0	4.372	6	1	1	1	221	23.6	7.03				1				1	130960.0391	269712.75	229605.0625	1640932	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;membrane;organelle lumen	catalytic activity;protein binding	Pf02815	23753	ENSG00000128228.4	SDF2L1	22			0
High	Q8N684	Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1	0.006	1.96	1	1	1	1	471	52	8	1				1				141889.4375	162310.125	201003.2344	183866.7344	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;nucleus	protein binding;RNA binding	"Pf00076, Pf14259"	79869	ENSG00000149532.15	CPSF7	11	Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway	mRNA surveillance pathway	0
Medium	P54802	Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2	0.011	1.781	3	1	1	1	743	82.2	6.65				1				1				115902				1		cell organization and biogenesis;metabolic process;response to stimulus	organelle lumen;vacuole	catalytic activity	"Pf05089, Pf12971, Pf12972"	4669	ENSG00000108784.9	NAGLU	17	MPS IIIB - Sanfilippo syndrome B; HS-GAG degradation	Lysosome; Glycosaminoglycan degradation; Metabolic pathways	0
Medium	Q9Y2X0	Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2	0.015	1.681	1	1	1	1	877	96.7	7.37			1				1		128845.5781	207251.4688	310241.8125	257466.5938	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	catalytic activity;protein binding;receptor activity	"Pf00400, Pf11635"	10025	ENSG00000175221.14	MED16	19	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
Medium	Q9P0L0	Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3	0.03	1.359	6	1	1	1	249	27.9	8.62			1				1			92417.11719	181057.3125	165600.8594		1	1	1		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoskeleton;endoplasmic reticulum;membrane;nucleus	protein binding;signal transducer activity	Pf00635	9218	ENSG00000101558.13	VAPA	18	Neutrophil degranulation; Sphingolipid de novo biosynthesis	Tight junction	0
Medium	Q13136	Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1	0.011	1.81	1	1	1	1	1202	135.7	6.29	1				1													cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;Golgi;nucleus	catalytic activity;motor activity;protein binding;signal transducer activity	"Pf00536, Pf01576, Pf02463, Pf04012, Pf04111, Pf04156, Pf05557, Pf05622, Pf06008, Pf06160, Pf06391, Pf07647, Pf09726, Pf09728, Pf09731, Pf10174, Pf12072, Pf12128, Pf12718, Pf12795, Pf13166, Pf13851, Pf14915, Pf15066, Pf15070, Pf15619"	8500	ENSG00000131626.16	PPFIA1	11	Norepinephrine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases; Glutamate Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle		0
Medium	Q10469	"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT2 PE=1 SV=1"	0.015	1.665	2	1	1	1	447	51.5	8.76				1				1										metabolic process	Golgi;membrane	catalytic activity	Pf05060	4247	ENSG00000168282.5	MGAT2	14	Defective MGAT2 causes MGAT2-CDG (CDG-2a); Reactions specific to the complex N-glycan synthesis pathway	N-Glycan biosynthesis; Metabolic pathways	0
High	Q6UB35	"Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1"	0.001	3.037	1	1	1	1	978	105.7	8.06				1				1	420424.75	94968.78906	178069.8438	238104.5938	1	1	1	1		metabolic process	membrane;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding	"Pf00763, Pf01268, Pf02882"	25902	ENSG00000120254.15	MTHFD1L	6	Metabolism of folate and pterines	One carbon pool by folate; Metabolic pathways	0
Medium	Q8IWV8	E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1	0.027	1.401	1	1	1	1	1755	200.4	6.24			1				1		321105.3125	343997.4375	268524.1563	315759.5313	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	"Pf02207, Pf02617"	23304	ENSG00000024048.10	UBR2	6	Antigen processing: Ubiquitination & Proteasome degradation		0
High	P15848	Arylsulfatase B OS=Homo sapiens OX=9606 GN=ARSB PE=1 SV=1	0.004	2.373	2	1	1	1	533	59.6	8.21				1				1				246805.5				1		cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;extracellular;Golgi;mitochondrion;organelle lumen;vacuole	catalytic activity;metal ion binding	"Pf00884, Pf14707"	411	ENSG00000113273.15	ARSB	5	MPS VI - Maroteaux-Lamy syndrome; Neutrophil degranulation; CS/DS degradation; The activation of arylsulfatases; Glycosphingolipid metabolism	Lysosome; Glycosaminoglycan degradation; Metabolic pathways	0
Medium	Q4VXA5	KH homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KHDC1 PE=2 SV=1	0.046	1.135	3	1	1	1	237	27.1	8.29			1				1				862281.0625				1				membrane	RNA binding		80759	ENSG00000135314.12	KHDC1	6			0
Medium	Q09161	Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1	0.019	1.561	1	1	1	1	790	91.8	6.43		1				1				373374.2188	308594.3438	396262.125		1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;mitochondrion;nucleus	protein binding;RNA binding	"Pf02854, Pf09088, Pf09090"	4686	ENSG00000136937.12	NCBP1	9	Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; SLBP independent Processing of Histone Pre-mRNAs; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; snRNP Assembly; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; mRNA 3'-end processing; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mRNA Capping; Regulation of expression of SLITs and ROBOs; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Formation of the Early Elongation Complex	Spliceosome; mRNA surveillance pathway; RNA transport	0
High	Q96GD4	Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3	0.003	2.523	4	1	1	1	344	39.3	9.29				1				1		69774.33594	129532.0234	266414.8125		1	1	1		cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytoskeleton;cytosol;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00069, Pf07714"	9212	ENSG00000178999.12	AURKB	17	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; SUMOylation of DNA replication proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Regulation of TP53 Activity through Phosphorylation		0
High	Q96HR3	Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1	0	3.691	7	1	1	1	178	20.3	8.27		1				1			318204.0938	386119.25	524098.875	500803.0313	1	1	1	1		metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;protein binding;receptor activity	Pf11315	90390	ENSG00000164758.7	MED30	8	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway	Thyroid hormone signaling pathway	0
Medium	Q9H944	Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1	0.036	1.256	5	1	1	1	212	23.2	6.87		1				1				5921991.5	5557005.5	5995592.5		1	1	1		cell differentiation;metabolic process;regulation of biological process	nucleus	catalytic activity;protein binding	Pf08612	9477	ENSG00000124641.15	MED20	6	Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway		0
High	Q9H9J2	"39S ribosomal protein L44, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1"	0.005	2.016	2	1	1	1	332	37.5	8.4			1				1		85845.46094	92032.94531	126219.375	149080.5313	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;nucleus;ribosome	catalytic activity;protein binding;RNA binding	Pf00636	65080	ENSG00000135900.3	MRPL44	2	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination		0
High	Q6ZXV5	Protein O-mannosyl-transferase TMTC3 OS=Homo sapiens OX=9606 GN=TMTC3 PE=1 SV=2	0	3.616	2	1	1	1	915	103.9	8.87			1				1				501172.875				1			regulation of biological process;response to stimulus	endoplasmic reticulum;membrane	protein binding	"Pf00515, Pf07719, Pf08409, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559"	160418		TMTC3	12			0
Medium	Q92504	Zinc transporter SLC39A7 OS=Homo sapiens OX=9606 GN=SLC39A7 PE=1 SV=2	0.03	1.323	3	1	1	1	469	50.1	6.87		1				1												cellular homeostasis;transport	endoplasmic reticulum;Golgi;membrane	protein binding;transporter activity	Pf02535	7922	ENSG00000227402.11; ENSG00000112473.17; ENSG00000206288.13; ENSG00000226614.11; ENSG00000224399.11; ENSG00000229802.11	SLC39A7	6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1	Zinc influx into cells by the SLC39 gene family		0
Medium	Q8IWX8	Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3	0.018	1.587	1	1	1	1	916	103.6	9.04		1				1			115836.3984	192699.9375	187319.8281	201281.9219	1	1	1	1		cellular homeostasis;metabolic process;regulation of biological process;transport	cytoplasm;endoplasmic reticulum;membrane	protein binding;RNA binding	"Pf01585, Pf01805, Pf04818"	10523	ENSG00000085872.14	CHERP	19	mRNA Splicing - Major Pathway	Spliceosome	0
High	Q8N766	ER membrane protein complex subunit 1 OS=Homo sapiens OX=9606 GN=EMC1 PE=1 SV=1	0.003	2.535	1	1	1	1	993	111.7	7.66				1				1			96607.5625	518008.8438			1	1		metabolic process	endoplasmic reticulum;membrane		"Pf07774, Pf13360"	23065	ENSG00000127463.13	EMC1	1			0
Medium	Q96SK2	Transmembrane protein 209 OS=Homo sapiens OX=9606 GN=TMEM209 PE=1 SV=2	0.015	1.66	4	1	1	1	561	62.9	8.63				1				1											membrane		Pf09786	84928	ENSG00000146842.16	TMEM209	7			0
High	Q8NF37	Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2	0	4.727	3	1	1	1	534	59.1	6.02				1				1			198048.3125	623768.125			1	1		metabolic process;regulation of biological process;transport	endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding	"Pf01553, Pf13833"	79888	ENSG00000153395.9	LPCAT1	5	Synthesis of PA; Synthesis of PC; Acyl chain remodelling of PG; Neutrophil degranulation; Acyl chain remodelling of PC	Ether lipid metabolism; Glycerophospholipid metabolism; Metabolic pathways	0
High	Q9H0S4	Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1	0.005	2.027	2	1	1	1	455	50.6	9.1			1				1				504378.8125	744969.625			1	1		cell death;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271"	51202	ENSG00000213782.7	DDX47	12	Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol		0
High	Q8WUZ0	B-cell CLL/lymphoma 7 protein family member C OS=Homo sapiens OX=9606 GN=BCL7C PE=1 SV=3	0.002	2.666	12	1	1	1	217	23.5	5.2				1				1										cell death			Pf04714	9274	ENSG00000099385.11	BCL7C	16			0
High	Q96MM7	Heparan-sulfate 6-O-sulfotransferase 2 OS=Homo sapiens OX=9606 GN=HS6ST2 PE=1 SV=2	0.007	1.917	1	1	1	1	605	69.1	9.73			1				1				166550.6406	79155.32813			1	1		metabolic process	membrane	catalytic activity	Pf03567	90161	ENSG00000171004.18	HS6ST2	X	HS-GAG biosynthesis	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0
High	P07858	Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3	0	3.862	5	1	1	1	339	37.8	6.3				1				1				394951.0938				1		cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;mitochondrion;organelle lumen;vacuole	catalytic activity;protein binding	"Pf00112, Pf08127"	1508	ENSG00000164733.20	CTSB	8	Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Neutrophil degranulation; MHC class II antigen presentation; Trafficking and processing of endosomal TLR	Lysosome; NOD-like receptor signaling pathway; Renin secretion; Apoptosis; Antigen processing and presentation	0
High	Q9GZS1	DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3	0.006	1.954	2	1	1	1	419	47.2	8.94			1				1		53852.80859		162370.0781	118636.0938	1		1	1												0
Medium	Q9UN37	Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1	0.041	1.204	4	1	1	1	437	48.9	7.8			1				1		150815.4531	150093.1875	214223.375	667950.9375	1	1	1	1		cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endosome;membrane;nucleus;vacuole	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf04389, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401"	27183	ENSG00000132612.15	VPS4A	16	Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)	Endocytosis	0
Low	Q53ET0	CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2	0.056	1.006	1	1	1	1	693	73.3	7.11				1				1			174394.625	436222.4375			1	1		cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;nucleus	protein binding	"Pf12884, Pf12885, Pf12886"	200186	ENSG00000160741.16	CRTC2	1	Transcriptional activation of mitochondrial biogenesis; Circadian Clock	Glucagon signaling pathway; HTLV-I infection; AMPK signaling pathway; Insulin resistance; PI3K-Akt signaling pathway	0
High	P11279	Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3	0	3.752	4	1	1	1	417	44.9	8.75			1				1											cell death;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endosome;membrane;vacuole	protein binding;receptor activity	Pf01299	3916	ENSG00000185896.10	LAMP1	13	Neutrophil degranulation	Lysosome; Tuberculosis; Phagosome	0
Medium	Q8TDN6	Ribosome biogenesis protein BRX1 homolog OS=Homo sapiens OX=9606 GN=BRIX1 PE=1 SV=2	0.023	1.42	2	1	1	1	353	41.4	9.92			1				1		127393.3203	97944.5	270657.25	162691.9688	1	1	1	1		cell organization and biogenesis	nucleus	RNA binding	Pf04427	55299	ENSG00000113460.12	BRIX1	5			0
Low	P52789	Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2	0.052	1.086	2	1	1	1	917	102.3	6.05			1				1											cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding	"Pf00349, Pf03727"	3099	ENSG00000159399.9	HK2	2	Glycolysis	"Insulin signaling pathway; HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Galactose metabolism; Type II diabetes mellitus; Neomycin, kanamycin and gentamicin biosynthesis; Starch and sucrose metabolism; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Carbohydrate digestion and absorption; Amino sugar and nucleotide sugar metabolism; Metabolic pathways"	0
Medium	Q08J23	RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2	0.036	1.264	2	1	1	1	767	86.4	6.77	1				1				135040.6563	116986.5078	267182.3125	210643.3281	1	1	1	1		cell division;metabolic process	cytoplasm;cytoskeleton;nucleus	catalytic activity;RNA binding	"Pf01189, Pf13659"	54888	ENSG00000037474.14	NSUN2	5	tRNA modification in the nucleus and cytosol		0
Low	P61218	"DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Homo sapiens OX=9606 GN=POLR2F PE=1 SV=1"	0.053	1.077	6	1	1	1	127	14.5	4.22		1				1			189064.9844	199324.1719	264484.5625		1	1	1			metabolic process;regulation of biological process;response to stimulus	cytosol;nucleus	catalytic activity;DNA binding	Pf01192	5435	ENSG00000100142.14	POLR2F	22	Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter	Epstein-Barr virus infection; Huntington's disease; Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Metabolic pathways; Pyrimidine metabolism	0
Medium	Q6EEV6	Small ubiquitin-related modifier 4 OS=Homo sapiens OX=9606 GN=SUMO4 PE=1 SV=2	0.036	1.256	13	1	1	1	95	10.7	7.18		1				1			112867.5859	280314.0938	481343.3125		1	1	1			metabolic process	nucleus	protein binding	"Pf00240, Pf11976"	387082		SUMO4	6		RNA transport	0
Medium	Q15800	Methylsterol monooxygenase 1 OS=Homo sapiens OX=9606 GN=MSMO1 PE=1 SV=1	0.039	1.224	4	1	1	1	293	35.2	7.23			1				1											metabolic process	endoplasmic reticulum;membrane	catalytic activity;metal ion binding	Pf04116	6307	ENSG00000052802.12	MSMO1	4	Cholesterol biosynthesis	Steroid biosynthesis; Metabolic pathways	0
Low	Q15833	Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2	0.051	1.102	3	1	1	1	593	66.4	6.55			1				1				129578.1641	184293.2813			1	1		regulation of biological process;transport	cytosol;extracellular;membrane;vacuole	protein binding	Pf00995	6813	ENSG00000076944.15	STXBP2	19	Platelet degranulation ; Other interleukin signaling		0
Medium	P68402	Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1	0.042	1.177	3	1	1	1	229	25.6	5.92	1				1				205215.6094				1					metabolic process;regulation of biological process;transport	cytoplasm;cytosol;extracellular;membrane;organelle lumen	catalytic activity;protein binding	"Pf00657, Pf13472"	5049	ENSG00000168092.13	PAFAH1B2	11	COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation	Ether lipid metabolism; Metabolic pathways	0
High	Q9NYF8	Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2	0.007	1.926	1	1	1	1	920	106.1	9.98			1				1		259640.0781	259336.375	365367.875	308087.4375	1	1	1	1		cell death;metabolic process;regulation of biological process;response to stimulus	cytoplasm;nucleus	DNA binding;protein binding;RNA binding	Pf15440	9774	ENSG00000029363.16	BCLAF1	6			0
Low	Q9Y5Z0	Beta-secretase 2 OS=Homo sapiens OX=9606 GN=BACE2 PE=1 SV=1	0.057	0.987	2	1	1	1	518	56.1	5.15				1				1				115986.1953				1		metabolic process;regulation of biological process	cell surface;endoplasmic reticulum;endosome;Golgi;membrane	catalytic activity	"Pf00026, Pf14541, Pf14543"	25825	ENSG00000182240.15	BACE2	21		Alzheimer's disease	0
Medium	P15104	Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4	0.017	1.611	5	1	1	1	373	42	6.89		1				1			163419.1406	280365.9688	150387.8125	249607.875	1	1	1	1		cell communication;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00120, Pf03951"	2752	ENSG00000135821.17	GLUL	1	Amino acid synthesis and interconversion (transamination); Astrocytic Glutamate-Glutamine Uptake And Metabolism	"Arginine biosynthesis; Glutamatergic synapse; Alanine, aspartate and glutamate metabolism; Biosynthesis of amino acids; GABAergic synapse; Nitrogen metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism"	0
Medium	O95490	Adhesion G protein-coupled receptor L2 OS=Homo sapiens OX=9606 GN=ADGRL2 PE=1 SV=2	0.03	1.364	1	1	1	1	1459	163.2	6.43			1				1											regulation of biological process;response to stimulus	membrane	receptor activity;signal transducer activity	"Pf00002, Pf01825, Pf02140, Pf02191, Pf02354, Pf02793, Pf12003"	23266	ENSG00000117114.19	LPHN2; ADGRL2	1			0
Medium	Q15051	IQ calmodulin-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=IQCB1 PE=1 SV=1	0.022	1.475	1	1	1	1	598	68.9	9.1		1				1				211442.9844		119242.0625		1		1		cell organization and biogenesis;regulation of biological process	cytoplasm;cytoskeleton;cytosol	protein binding	Pf00612	9657	ENSG00000173226.16	IQCB1	3	Anchoring of the basal body to the plasma membrane		0
Medium	P61962	DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1	0.023	1.411	6	1	1	1	342	38.9	5.52	1				1				168641.6406	246425.9219	259760.9688	207656.625	1	1	1	1		development;metabolic process	cytoplasm;cytosol;nucleus	protein binding	Pf00400	10238	ENSG00000136485.14	DCAF7	17	Association of TriC/CCT with target proteins during biosynthesis; Neddylation		0
High	Q92947	"Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1"	0	4.378	3	1	1	1	438	48.1	8.06				1				1			148851.7969	327554.8125			1	1		metabolic process	mitochondrion;organelle lumen	catalytic activity;nucleotide binding	"Pf00441, Pf02770, Pf02771, Pf08028"	2639	ENSG00000105607.12	GCDH	19	Lysine catabolism	Fatty acid degradation; Lysine degradation; Metabolic pathways; Tryptophan metabolism	0
High	Q08431	Lactadherin OS=Homo sapiens OX=9606 GN=MFGE8 PE=1 SV=3	0.001	2.973	5	1	1	1	387	43.1	8.15				1				1				731286.625				1												0
High	Q9BX73	TM2 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TM2D2 PE=1 SV=1	0.005	2.05	13	1	1	1	214	22.9	4.97				1				1				560119.5625				1			membrane		Pf05154	83877	ENSG00000169490.16	TM2D2	8			0
Medium	Q8WUA4	General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2	0.011	1.797	1	1	1	1	911	100.6	7.31	1				1				124751.8594	45657.39453			1	1				metabolic process	nucleus	DNA binding;protein binding	Pf00400	2976	ENSG00000115207.13	GTF3C2	2	RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter		0
Medium	Q9UMR2	ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1	0.028	1.385	2	1	1	1	479	53.9	6.3				1				1		77778.63281		302048.7813		1		1		metabolic process;regulation of biological process;transport	cytoplasm;membrane;nucleus;spliceosomal complex	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271"	11269	ENSG00000157349.16	DDX19B	16			0
Medium	Q6IAN0	Dehydrogenase/reductase SDR family member 7B OS=Homo sapiens OX=9606 GN=DHRS7B PE=1 SV=2	0.017	1.623	2	1	1	1	325	35.1	9.55				1				1				443293.6875				1		metabolic process	endoplasmic reticulum;membrane	catalytic activity	"Pf00106, Pf08659, Pf13460, Pf13561"	25979	ENSG00000109016.17	DHRS7B	17			0
High	P98170	E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2	0.005	1.991	3	1	1	1	497	56.6	6.65			1				1		463145.0938	458174.5938	513600.25	697131.5	1	1	1	1		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;enzyme regulator activity;metal ion binding;protein binding	"Pf00653, Pf13920, Pf13923"	331	ENSG00000101966.12	XIAP	X	Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization	NOD-like receptor signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Apoptosis - multiple species; NF-kappa B signaling pathway; HTLV-I infection; Toxoplasmosis; Apoptosis; Focal adhesion; Small cell lung cancer; Platinum drug resistance	0
High	Q15011	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1	0.001	3.426	2	1	1	1	391	43.7	5.25			1				1				230597.3281	143528.5156			1	1		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane	protein binding	Pf00240	9709	ENSG00000051108.14	HERPUD1	16	ATF4 activates genes	Protein processing in endoplasmic reticulum	0
High	Q13618	Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2	0.004	2.239	2	1	1	1	768	88.9	8.48	1				1				187979.7344				1					cell death;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;Golgi;membrane;nucleus	catalytic activity;protein binding	"Pf00888, Pf10557"	8452	ENSG00000036257.12	CUL3	2	Hedgehog 'on' state; Regulation of RAS by GAPs; Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Interleukin-20 family signaling	Ubiquitin mediated proteolysis; Hedgehog signaling pathway	0
Medium	A0A0B4J249	T cell receptor alpha variable 5 OS=Homo sapiens OX=9606 GN=TRAV5 PE=3 SV=1	0.043	1.151	6	1	1	1	113	13	4.97	1				1				1210717	1763180.375	4570542	5216981.5	1	1	1	1					"Pf00047, Pf07679, Pf07686"		ENSG00000211779.3		14			0
High	Q8NBJ5	Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1	0.005	2.032	1	1	1	1	622	71.6	7.31				1				1				407049.3438				1			endoplasmic reticulum;membrane;organelle lumen	catalytic activity	"Pf00535, Pf01755, Pf13641"	79709	ENSG00000130309.10	COLGALT1; GLT25D1	19	Collagen biosynthesis and modifying enzymes	Lysine degradation; Other types of O-glycan biosynthesis	0
High	Q5VUD6	Divergent protein kinase domain 1B OS=Homo sapiens OX=9606 GN=DIPK1B PE=1 SV=3	0.004	2.351	3	1	1	1	431	48.6	8.68				1				1											endoplasmic reticulum;membrane	protein binding	"Pf12260, Pf14875"	138311	ENSG00000165716.10	FAM69B	9			0
Medium	Q7L2E3	ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1	0.044	1.143	1	1	1	1	1194	133.9	8.78			1				1											cell organization and biogenesis;metabolic process	cytoplasm;cytosol;mitochondrion	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf04408, Pf07717"	22907	ENSG00000132153.14	DHX30	3			0
Medium	Q9BVI4	Nucleolar complex protein 4 homolog OS=Homo sapiens OX=9606 GN=NOC4L PE=1 SV=1	0.048	1.117	3	1	1	1	516	58.4	7.49			1				1			156030.2344	318611.2188			1	1			metabolic process	membrane;nucleus	protein binding;RNA binding	"Pf03914, Pf14838"	79050	ENSG00000184967.6	NOC4L	12	Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol		0
Medium	O94776	Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1	0.042	1.153	1	1	1	1	668	75	9.66	1				1				113649.3906	100797.7344	158728.3125	167574.8125	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process	membrane;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding	"Pf00249, Pf00320, Pf01426, Pf01448"	9219	ENSG00000149480.6	MTA2	11	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation		0
Medium	P24534	Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3	0.019	1.573	4	1	1	1	225	24.7	4.67				1				1	387694.5		519273.3438	519973.875	1		1	1		metabolic process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;nucleus	protein binding;RNA binding	"Pf00736, Pf14497"	1933	ENSG00000283391.1; ENSG00000114942.13	EEF1B2	2; CHR_HSCHR2_6_CTG7_2	Eukaryotic Translation Elongation		0
Medium	Q8TCS8	"Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2"	0.022	1.435	1	1	1	1	783	85.9	7.77	1				1													cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome	catalytic activity;protein binding;RNA binding	"Pf00013, Pf00575, Pf01138, Pf03725, Pf03726"	87178	ENSG00000138035.14	PNPT1	2		Purine metabolism; RNA degradation; Pyrimidine metabolism	0
Low	P35249	Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2	0.054	1.076	3	1	1	1	363	39.7	8.02			1				1				554966.875	281707.3438			1	1		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding	"Pf00004, Pf03215, Pf05496, Pf08542, Pf09848, Pf13086, Pf13177, Pf13191, Pf13245, Pf13401, Pf13481, Pf13604"	5984	ENSG00000163918.10	RFC4	3	Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA)	DNA replication; Mismatch repair; Nucleotide excision repair	0
Medium	Q7Z4R8	UPF0669 protein C6orf120 OS=Homo sapiens OX=9606 GN=C6orf120 PE=1 SV=1	0.021	1.511	14	1	1	1	191	20.8	4.84			1				1											cell death;transport	extracellular;organelle lumen			387263	ENSG00000185127.6	C6orf120	6	Neutrophil degranulation		0
Medium	Q96AK3	DNA dC->dU-editing enzyme APOBEC-3D OS=Homo sapiens OX=9606 GN=APOBEC3D PE=1 SV=1	0.043	1.152	3	1	1	1	386	46.6	8.4				1				1	124199.5313	207132.4375	243081	175005.5625	1	1	1	1		defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm	catalytic activity;metal ion binding	"Pf05240, Pf08210"	140564	ENSG00000243811.8; ENSG00000284554.1	APOBEC3D	22			0
Medium	Q9NUD5	Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2	0.011	1.755	4	1	1	1	403	43.5	8.53				1				1	68806.33594	720321.4375	496690.4063	432626.75	1	1	1	1												0
High	A0A0C4DH72	Immunoglobulin kappa variable 1-6 OS=Homo sapiens OX=9606 GN=IGKV1-6 PE=3 SV=1	0.004	2.203	14	1	1	1	117	12.7	8.29	1				1				1451485.75		187041.4531	227712.9375	1		1	1		response to stimulus	extracellular;membrane		"Pf00047, Pf07679, Pf07686, Pf13927"	28943	ENSG00000282163.1; ENSG00000239855.1	IGKV1-6	2; CHR_HG2290_PATCH			0
Medium	Q9HBE1	"POZ-, AT hook-, and zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=PATZ1 PE=1 SV=1"	0.031	1.328	1	1	1	1	687	74	8.35	1				1				243929.5313	119879.3516			1	1				cell differentiation;metabolic process;regulation of biological process	nucleus	DNA binding;metal ion binding;protein binding	"Pf00651, Pf13465"	23598	ENSG00000100105.17	PATZ1	22			0
High	P37108	Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2	0.006	1.974	6	1	1	1	136	14.6	10.04				1				1	217674.9063	356740.9063	374545.5938	352586.5938	1	1	1	1		cell organization and biogenesis;response to stimulus;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen	protein binding;RNA binding	Pf02290	6727	ENSG00000140319.10	SRP14	15	Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane	Protein export	0
Medium	Q6P4Q7	Metal transporter CNNM4 OS=Homo sapiens OX=9606 GN=CNNM4 PE=1 SV=3	0.018	1.598	1	1	1	1	775	86.6	6.07			1				1				205412.9375	110855.2266			1	1		response to stimulus;transport	membrane	protein binding;transporter activity	"Pf00571, Pf01595"	26504	ENSG00000158158.11	CNNM4	2			0
Medium	P00734	Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2	0.028	1.395	1	1	1	1	622	70	5.9			1				1			96490.67188	124296.4766	85152.04688		1	1	1		cellular component movement;cellular homeostasis;coagulation;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity	"Pf00051, Pf00089, Pf00594, Pf09342, Pf09396"	2147	ENSG00000180210.14	F2	11	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors; Thrombin signalling through proteinase activated receptors (PARs); Platelet Aggregation (Plug Formation); Regulation of Complement cascade; Common Pathway of Fibrin Clot Formation; Gastrin-CREB signalling pathway via PKC and MAPK; Cell surface interactions at the vascular wall	Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Regulation of actin cytoskeleton	0
Low	Q8N3K9	Cardiomyopathy-associated protein 5 OS=Homo sapiens OX=9606 GN=CMYA5 PE=1 SV=3	0.052	1.088	0	1	1	1	4069	448.9	4.78		1				1			11840054	16564375	16588441	14396900	1	1	1	1			cytoplasm	protein binding	"Pf00041, Pf00622"	202333	ENSG00000164309.14	CMYA5	5			0
Medium	Q8TCT7	Signal peptide peptidase-like 2B OS=Homo sapiens OX=9606 GN=SPPL2B PE=1 SV=2	0.023	1.409	1	1	1	1	592	64.6	8.32				1				1				198042.6563				1		metabolic process;regulation of biological process	cytoskeleton;endosome;Golgi;membrane;vacuole	catalytic activity;protein binding	"Pf02225, Pf04258, Pf05887, Pf07223, Pf09606"	56928	ENSG00000005206.16	SPPL2B	19	Regulation of TNFR1 signaling		0
High	Q6UN15	Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1	0.004	2.315	2	1	1	1	594	66.5	5.59	1				1													metabolic process;transport	nucleus	protein binding;RNA binding	Pf05182	81608	ENSG00000145216.15	FIP1L1	4	mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs	mRNA surveillance pathway	0
Low	Q8IV04	Carabin OS=Homo sapiens OX=9606 GN=TBC1D10C PE=1 SV=1	0.057	0.994	2	1	1	1	446	49.7	8.76				1				1		2534205	15419688	10668113		1	1	1		regulation of biological process;transport	cytosol;membrane	enzyme regulator activity;protein binding	Pf00566	374403	ENSG00000175463.11	TBC1D10C	11	TBC/RABGAPs; Neutrophil degranulation		0
Medium	Q9H2U1	ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2	0.017	1.632	1	1	1	1	1008	114.7	7.68	1				1				144095.375	65466.15234	125265.1719		1	1	1			metabolic process;regulation of biological process;response to stimulus	chromosome;cytoplasm;cytosol;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00270, Pf00271, Pf02562, Pf04408, Pf07717"	170506	ENSG00000174953.13	DHX36	3	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; TRAF6 mediated IRF7 activation	RNA degradation	0
Medium	O43529	Carbohydrate sulfotransferase 10 OS=Homo sapiens OX=9606 GN=CHST10 PE=1 SV=1	0.011	1.773	3	1	1	1	356	42.2	8.03				1				1										metabolic process	Golgi;membrane	catalytic activity	Pf03567	9486	ENSG00000115526.10	CHST10	2	Reactions specific to the complex N-glycan synthesis pathway	Other types of O-glycan biosynthesis	0
Medium	P35625	Metalloproteinase inhibitor 3 OS=Homo sapiens OX=9606 GN=TIMP3 PE=1 SV=2	0.039	1.223	4	1	1	1	211	24.1	8.72				1				1	74764.47656	47232.99219	95605.21094	295678.125	1	1	1	1		regulation of biological process;response to stimulus;transport	extracellular;nucleus;organelle lumen	enzyme regulator activity;metal ion binding;protein binding	Pf00965	7078	ENSG00000100234.11	TIMP3	22	Platelet degranulation	MicroRNAs in cancer; Proteoglycans in cancer	0
High	Q13444	Disintegrin and metalloproteinase domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ADAM15 PE=1 SV=4	0.001	3.095	2	1	1	1	863	92.9	6.73				1				1			208916.3906	670395.8125			1	1		cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;membrane	catalytic activity;metal ion binding;protein binding	"Pf00200, Pf00413, Pf01421, Pf01562, Pf08516, Pf13574, Pf13582, Pf13583, Pf13688"	8751	ENSG00000143537.13	ADAM15	1	Degradation of the extracellular matrix; Invadopodia formation		0
Medium	Q6YN16	Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1	0.021	1.518	3	1	1	1	418	45.4	7.99			1				1		162801.125	265314.6875	210883.7656	261009.8906	1	1	1	1		metabolic process	membrane;mitochondrion	catalytic activity	"Pf00106, Pf02036, Pf13561, Pf14864"	84263	ENSG00000119471.14	HSDL2	9			0
Medium	Q9Y5V3	Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3	0.036	1.263	1	1	1	1	778	86.1	5.83	1				1				196279.0938	216810.9219	353355.1875	755040.125	1	1	1	1		regulation of biological process	chromosome;cytoplasm;membrane;nucleus	protein binding	"Pf00874, Pf01454"	9500	ENSG00000179222.17	MAGED1	X	Ligand-independent caspase activation via DCC; NRAGE signals death through JNK; Signalling by NGF	Neurotrophin signaling pathway	0
High	Q9UBX3	Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 GN=SLC25A10 PE=1 SV=2	0.005	1.986	4	1	1	1	287	31.3	9.54				1				1			411634.4063	650772.4375			1	1		metabolic process;transport	membrane;mitochondrion;nucleus	protein binding;transporter activity	Pf00153	1468	ENSG00000183048.11	SLC25A10	17	Gluconeogenesis; Sulfide oxidation to sulfate; Organic anion transporters	Proximal tubule bicarbonate reclamation	0
Medium	P52732	Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2	0.03	1.323	1	1	1	1	1056	119.1	5.64	1				1				193870.4844				1					cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;membrane	catalytic activity;motor activity;nucleotide binding;protein binding	"Pf00225, Pf13931"	3832	ENSG00000138160.5	KIF11	10	COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation		0
High	P43003	Excitatory amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC1A3 PE=1 SV=1	0	5.006	2	1	1	1	542	59.5	8.41				1				1				519192.5313				1		cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;membrane	metal ion binding;transporter activity	Pf00375	6507	ENSG00000079215.13	SLC1A3	5	Defective SLC1A3 causes episodic ataxia 6 (EA6); Glutamate Neurotransmitter Release Cycle; Astrocytic Glutamate-Glutamine Uptake And Metabolism; Transport of inorganic cations/anions and amino acids/oligopeptides	Glutamatergic synapse	0
High	Q9Y2G8	DnaJ homolog subfamily C member 16 OS=Homo sapiens OX=9606 GN=DNAJC16 PE=2 SV=3	0.005	2.054	1	1	1	1	782	90.5	7.12				1				1	119455.7188	128083.7813	219783.5	329875.25	1	1	1	1		cellular homeostasis;regulation of biological process	cytosol;membrane		"Pf00085, Pf00226"	23341	ENSG00000116138.12	DNAJC16	1			0
Low	Q9P2D8	Protein unc-79 homolog OS=Homo sapiens OX=9606 GN=UNC79 PE=2 SV=4	0.055	1.053	1	1	1	1	2635	295.1	6.32			1				1											response to stimulus;transport	membrane	protein binding	Pf14776	57578	ENSG00000133958.13; ENSG00000276416.3	UNC79	14; CHR_HSCHR14_7_CTG1	Stimuli-sensing channels		0
Medium	O15027	Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4	0.015	1.691	1	1	1	1	2357	251.7	5.8	1				1				72985.5		65894.36719		1		1													0
Low	Q1X8D7	Leucine-rich repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=LRRC36 PE=1 SV=2	0.054	1.071	1	1	1	1	754	83.8	7.15		1				1				362156.3438				1						protein binding	"Pf12799, Pf13855, Pf14580"	55282	ENSG00000159708.17	LRRC36	16			0
Low	Q9NRF8	CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1	0.054	1.066	1	1	1	1	586	65.6	6.9		1				1			596835.75	318038.5938	313589.4375	594270.9375	1	1	1	1		metabolic process	cytosol	catalytic activity;nucleotide binding;protein binding	"Pf00117, Pf06418, Pf07722"	56474	ENSG00000047230.14	CTPS2	X	Interconversion of nucleotide di- and triphosphates	Metabolic pathways; Pyrimidine metabolism	0
Medium	P40938	Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2	0.03	1.337	3	1	1	1	356	40.5	8.34			1				1			257426.5156	382704.3125	511215.1875		1	1	1		cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;DNA binding;protein binding	"Pf03215, Pf08542, Pf13177, Pf13401"	5983	ENSG00000133119.12	RFC3	13	Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA)	DNA replication; Mismatch repair; Nucleotide excision repair	0
Medium	Q6P4F1	"Alpha-(1,3)-fucosyltransferase 10 OS=Homo sapiens OX=9606 GN=FUT10 PE=2 SV=2"	0.038	1.226	1	1	1	1	479	56.1	8.37				1				1		148793.8438	167357.4531	345344.625		1	1	1		cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;Golgi;membrane	catalytic activity	Pf00852	84750	ENSG00000172728.15	FUT10	8			0
Medium	P85037	Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1	0.022	1.481	1	1	1	1	733	75.4	9.32			1				1			124581.6406	246579.4063	190449.7188		1	1	1		cell differentiation;development;metabolic process;regulation of biological process	nucleus	DNA binding;protein binding	"Pf00250, Pf00498"	221937	ENSG00000164916.10	FOXK1	7	UCH proteinases		0
Low	Q9UGJ0	5'-AMP-activated protein kinase subunit gamma-2 OS=Homo sapiens OX=9606 GN=PRKAG2 PE=1 SV=1	0.053	1.079	2	1	1	1	569	63	9.35		1				1			2943728	3128493.25	2267163.25	1631702.25	1	1	1	1		cell communication;metabolic process;regulation of biological process;response to stimulus;transport	cytosol	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	"Pf00478, Pf00571"	51422	ENSG00000106617.13	PRKAG2	7	Translocation of GLUT4 to the plasma membrane; Energy dependent regulation of mTOR by LKB1-AMPK; Import of palmitoyl-CoA into the mitochondrial matrix; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation	Longevity regulating pathway - multiple species; Insulin signaling pathway; FoxO signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; AMPK signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Circadian rhythm; Insulin resistance; Adipocytokine signaling pathway; Longevity regulating pathway; Hypertrophic cardiomyopathy (HCM)	0
High	P22102	Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1	0.004	2.115	1	1	1	1	1010	107.7	6.7			1				1											metabolic process;response to stimulus	cytoplasm;cytosol	catalytic activity;metal ion binding;nucleotide binding	"Pf00551, Pf00586, Pf01071, Pf02222, Pf02655, Pf02769, Pf02843, Pf02844, Pf03435, Pf07478, Pf08442, Pf08443, Pf13535, Pf15632"	2618	ENSG00000159131.16	GART	21	Purine ribonucleoside monophosphate biosynthesis	Antifolate resistance; Purine metabolism; One carbon pool by folate; Metabolic pathways	0
Medium	Q86UE8	Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2	0.022	1.477	1	1	1	1	772	87.6	8.41			1				1				184632.7188	45066.65625			1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00069, Pf07714"	11011	ENSG00000146872.17	TLK2	17			0
High	P60900	Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1	0.003	2.411	5	1	1	1	246	27.4	6.76				1				1		277079.375	240876.1875	666767.6875		1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00227, Pf10584"	5687	ENSG00000100902.10	PSMA6	14	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
Medium	Q8IYK4	Procollagen galactosyltransferase 2 OS=Homo sapiens OX=9606 GN=COLGALT2 PE=1 SV=1	0.021	1.52	1	1	1	1	626	72.9	6.2				1				1	142787.0625		341295.0313	735691.5	1		1	1			endoplasmic reticulum;organelle lumen	catalytic activity;protein binding	"Pf01755, Pf13704"	23127	ENSG00000198756.10	COLGALT2; GLT25D2	1	Collagen biosynthesis and modifying enzymes	Lysine degradation; Other types of O-glycan biosynthesis	0
Medium	Q07866	Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2	0.031	1.333	2	1	1	1	573	65.3	6.2	1				1				228717.875	79471.375	133603.4375	119857.8906	1	1	1	1		cell organization and biogenesis;cellular component movement;transport	cytoplasm;cytoskeleton;cytosol;membrane	catalytic activity;motor activity;protein binding	"Pf08317, Pf09311, Pf13374, Pf13414, Pf13424, Pf13432, Pf14559"	3831	ENSG00000126214.21	KLC1	14	COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; MHC class II antigen presentation	Salmonella infection	0
Medium	Q99873	Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3	0.044	1.147	3	1	1	1	371	42.4	5.35	1				1				271666.9063	334000.7813	385152.0625		1	1	1													0
High	O43657	Tetraspanin-6 OS=Homo sapiens OX=9606 GN=TSPAN6 PE=1 SV=1	0.003	2.478	5	1	1	1	245	27.5	8.1				1				1										regulation of biological process;response to stimulus	membrane	protein binding;signal transducer activity	Pf00335	7105	ENSG00000000003.14	TSPAN6	X			0
Medium	O14529	Homeobox protein cut-like 2 OS=Homo sapiens OX=9606 GN=CUX2 PE=1 SV=4	0.042	1.155	1	1	1	1	1486	161.6	5.48			1				1				1941790.375				1			development;metabolic process;regulation of biological process;response to stimulus;transport	membrane;nucleus	catalytic activity;DNA binding;motor activity	"Pf00046, Pf00261, Pf01576, Pf02376, Pf05622, Pf07851, Pf10267, Pf15397"	23316	ENSG00000111249.13	CUX2	12			0
High	Q9Y3A6	Transmembrane emp24 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TMED5 PE=1 SV=1	0.007	1.919	5	1	1	1	229	26	4.84				1				1										cell organization and biogenesis;transport	endoplasmic reticulum;Golgi;membrane	protein binding	Pf01105	50999	ENSG00000117500.12	TMED5	1	WNT ligand biogenesis and trafficking		0
High	O15321	Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=2	0.003	2.577	2	1	1	1	606	68.8	7.17				1				1										metabolic process	membrane;vacuole		Pf02990	10548	ENSG00000100926.14	TM9SF1	14			0
Medium	P23258	Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2	0.03	1.343	2	1	1	1	451	51.1	6.14				1				1	232566.7344		189431.3906	314355.8125	1		1	1		cell organization and biogenesis;regulation of biological process	chromosome;cytoplasm;cytoskeleton;cytosol;endosome	catalytic activity;nucleotide binding;protein binding;structural molecule activity	"Pf00091, Pf03953"	7283	ENSG00000131462.7	TUBG1	17	Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes		0
Medium	P0DN79	Cystathionine beta-synthase-like protein OS=Homo sapiens OX=9606 GN=CBSL PE=1 SV=1	0.033	1.307	1	1	1	1	551	60.5	6.65				1				1	194686.0313	107476.1875	169474.5781	200773.3125	1	1	1	1		cell communication;metabolic process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;metal ion binding;protein binding	"Pf00291, Pf00571"	875; 102724560	ENSG00000160200.17; ENSG00000274276.4	CBS; LOC102724560; CBSL	21	"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine"	"Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways; Cysteine and methionine metabolism"	0
High	Q9P2R7	"Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3"	0.001	3.149	2	1	1	1	463	50.3	7.42				1				1										metabolic process	mitochondrion;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00549, Pf01071, Pf02222, Pf08442, Pf13535, Pf13549"	8803	ENSG00000136143.14	SUCLA2	13	Citric acid cycle (TCA cycle)	Propanoate metabolism; Citrate cycle (TCA cycle); Carbon metabolism; Metabolic pathways	0
High	Q12904	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2	0.005	1.996	3	1	1	1	312	34.3	8.43				1				1	386493.7813	573501.6875		704156	1	1		1		cell communication;cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus	protein binding;RNA binding	Pf01588	9255	ENSG00000164022.16	AIMP1	4	Cytosolic tRNA aminoacylation; SeMet incorporation into proteins		0
Medium	Q92791	Endoplasmic reticulum protein SC65 OS=Homo sapiens OX=9606 GN=P3H4 PE=1 SV=1	0.015	1.676	3	1	1	1	437	50.3	4.77				1				1				733055.6875				1		cell organization and biogenesis;metabolic process	chromosome;endoplasmic reticulum	protein binding		10609	ENSG00000141696.12	LEPREL4; P3H4	17			0
Medium	Q99417	c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3	0.022	1.454	9	1	1	1	103	12	5.91	1				1				258395.1563	68222.73438			1	1				metabolic process;regulation of biological process	cytoplasm;cytosol;mitochondrion;nucleus	protein binding		26292	ENSG00000214114.8	MYCBP	1			0
High	O43865	S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2	0.006	1.958	2	1	1	1	530	58.9	6.89				1				1		363988.1875	359161.3125	398958.75		1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;membrane	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00670, Pf01262, Pf01488, Pf02254, Pf02826, Pf05221"	10768	ENSG00000168710.17	AHCYL1	1	Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; DAG and IP3 signaling; Signaling by GPCR; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis	Metabolic pathways; Cysteine and methionine metabolism	0
Medium	Q5VIR6	Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=1	0.04	1.2	3	1	1	1	699	79.6	6.02		1				1			5230145.5	4881109	5710161.5	3498551.5	1	1	1	1		transport	cytosol;endosome;Golgi;membrane	protein binding	"Pf04100, Pf13166"	55275	ENSG00000141252.19; ENSG00000283883.1	VPS53	17; CHR_HG2285_HG106_HG2252_PATCH	Retrograde transport at the Trans-Golgi-Network		0
Medium	Q92820	Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2	0.02	1.535	3	1	1	1	318	35.9	7.11				1				1				437099.9063				1		metabolic process;response to stimulus;transport	cytosol;extracellular;nucleus;organelle lumen;vacuole	catalytic activity	"Pf00117, Pf07722"	8836	ENSG00000137563.11	GGH	8	Neutrophil degranulation	Folate biosynthesis; Antifolate resistance	0
High	Q92665	"28S ribosomal protein S31, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3"	0.003	2.436	4	1	1	1	395	45.3	9.29			1				1		126970.5078	127914.5859	182101.5938	162402.1875	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	protein binding;RNA binding;structural molecule activity	Pf15433	10240	ENSG00000102738.7	MRPS31	13	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination		0
Medium	Q13409	Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3	0.022	1.427	1	1	1	1	638	71.4	5.2	1				1				141490.5156				1					cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;Golgi;mitochondrion;organelle lumen	catalytic activity;motor activity;protein binding	"Pf00400, Pf11540"	1781	ENSG00000077380.15	DYNC1I2	2	COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR)	Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption	0
Medium	Q15629	Translocating chain-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=TRAM1 PE=1 SV=3	0.03	1.345	5	1	1	1	374	43	9.63				1				1										cell organization and biogenesis;transport	endoplasmic reticulum;membrane	protein binding;receptor activity	"Pf03798, Pf08390"	23471	ENSG00000067167.7	TRAM1	8	SRP-dependent cotranslational protein targeting to membrane	Protein processing in endoplasmic reticulum	0
Medium	Q86SF2	N-acetylgalactosaminyltransferase 7 OS=Homo sapiens OX=9606 GN=GALNT7 PE=1 SV=1	0.046	1.122	2	1	1	1	657	75.3	7.11				1				1	1638484.625	1693560.125	1693547.375	2734067.75	1	1	1	1		metabolic process	Golgi;membrane	catalytic activity;metal ion binding	"Pf00535, Pf00652, Pf02709, Pf10111"	51809	ENSG00000109586.11	GALNT7	4	O-linked glycosylation of mucins	Mucin type O-glycan biosynthesis; Metabolic pathways	0
Low	P43686	26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2	0.052	1.082	3	1	1	1	418	47.3	5.21				1				1	54114.42969	38794.58984	109581.6016	156868.7188	1	1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00006, Pf00910, Pf01057, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191"	5704	ENSG00000281221.2; ENSG00000013275.7	PSMC4	19; CHR_HG2021_PATCH	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Epstein-Barr virus infection; Proteasome	0
High	Q96IZ7	Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1	0	4.179	3	1	1	1	334	38.7	11.08			1				1			247149.1719	491083.375			1	1			metabolic process;response to stimulus;transport	cytoplasm;nucleus	protein binding		51319	ENSG00000174891.12	RSRC1	3			0
Medium	Q9H3N1	Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1	0.028	1.385	4	1	1	1	280	31.8	4.98				1				1	113878.625		64668.94141	434820.5625	1		1	1		cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;membrane	catalytic activity	"Pf00085, Pf13098"	81542	ENSG00000139921.12	TMX1	14			0
Medium	Q9Y6J0	Calcineurin-binding protein cabin-1 OS=Homo sapiens OX=9606 GN=CABIN1 PE=1 SV=1	0.011	1.783	1	1	1	1	2220	246.2	6.02		1				1				210662.5625	191640.7344	152188.9063		1	1	1		cell organization and biogenesis;regulation of biological process;response to stimulus	cytosol;nucleus	enzyme regulator activity;protein binding	"Pf09047, Pf13414"	23523	ENSG00000099991.17	CABIN1	22	Formation of Senescence-Associated Heterochromatin Foci (SAHF)		0
High	Q9NVE7	4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1	0.003	2.448	2	1	1	1	773	85.9	6.28	1				1				229321.0781			144793.1406	1			1		metabolic process	cytoplasm	catalytic activity;nucleotide binding	"Pf01937, Pf03630"	55229	ENSG00000273494.3	PANK4	1; CHR_HSCHR1_1_CTG3	Coenzyme A biosynthesis	Pantothenate and CoA biosynthesis; Metabolic pathways	0
Medium	P30876	DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1	0.014	1.714	1	1	1	1	1174	133.8	6.87	1				1													metabolic process;regulation of biological process;response to stimulus	membrane;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	"Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567"	5431	ENSG00000047315.15	POLR2B	4	Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex	Epstein-Barr virus infection; Huntington's disease; Purine metabolism; RNA polymerase; Metabolic pathways; Pyrimidine metabolism	0
Medium	Q07864	DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5	0.011	1.815	1	1	1	1	2286	261.4	6.39			1				1		71027.375	225948.8281	194740.3281	207958.6875	1	1	1	1		cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus	membrane;nucleus	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	"Pf00136, Pf03104, Pf08490, Pf10108, Pf13482"	5426	ENSG00000177084.16	POLE	12	Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Activation of the pre-replicative complex; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; M/G1 Transition; Termination of translesion DNA synthesis; Recognition of DNA damage by PCNA-containing replication complex; DNA replication initiation; Dual incision in TC-NER; Telomere C-strand synthesis initiation; PCNA-Dependent Long Patch Base Excision Repair	DNA replication; Purine metabolism; Base excision repair; HTLV-I infection; Nucleotide excision repair; Metabolic pathways; Pyrimidine metabolism	0
Medium	Q9H0A0	RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2	0.017	1.607	1	1	1	1	1025	115.7	8.27	1				1				197677.3906	129660.2578	266400.5938	229942.9219	1	1	1	1		metabolic process;regulation of biological process	membrane;nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00583, Pf05127, Pf08351, Pf13508, Pf13718, Pf13725"	55226	ENSG00000135372.8	NAT10	11	rRNA modification in the nucleus and cytosol	Ribosome biogenesis in eukaryotes	0
Medium	P56537	Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1	0.028	1.374	4	1	1	1	245	26.6	4.68			1				1		135464	110160.6406	165349.6875	161954.9375	1	1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus	protein binding;RNA binding	Pf01912	3692	ENSG00000242372.6	EIF6	20		Ribosome biogenesis in eukaryotes	0
Medium	Q05048	Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1	0.045	1.134	3	1	1	1	431	48.3	6.58	1				1				281455.25		47289.16406		1		1			metabolic process	nucleus	protein binding;RNA binding	"Pf00400, Pf11768"	1477	ENSG00000101138.11	CSTF1	20	Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway	mRNA surveillance pathway	0
Medium	Q9NP79	Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1	0.011	1.822	5	1	1	1	307	33.9	6.29	1				1				319227.5313				1				Met-loss+Acetyl [N-Term]	cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport	cytoplasm;cytosol;endosome;membrane	protein binding	Pf04652	51534	ENSG00000009844.15	VTA1	6	Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)	Endocytosis	0
Medium	Q8NEW0	Zinc transporter 7 OS=Homo sapiens OX=9606 GN=SLC30A7 PE=2 SV=1	0.021	1.517	3	1	1	1	376	41.6	6.95				1				1		99762.4375	236859.1563	312357.5938		1	1	1		regulation of biological process;response to stimulus;transport	cytoplasm;Golgi;membrane	transporter activity	Pf01545	148867	ENSG00000162695.11	SLC30A7	1	Insulin processing; Zinc efflux and compartmentalization by the SLC30 family		0
High	Q96EY1	"DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2"	0.004	2.301	3	1	1	1	480	52.5	9.26				1				1	71528.61719		183604.2969	521824.625	1		1	1		cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen	enzyme regulator activity;metal ion binding;nucleotide binding;protein binding	"Pf00226, Pf00684, Pf01556"	9093	ENSG00000276726.4; ENSG00000103423.13	DNAJA3	16; CHR_HSCHR16_3_CTG1		Viral carcinogenesis	0
Medium	Q6ZU65	Ubinuclein-2 OS=Homo sapiens OX=9606 GN=UBN2 PE=1 SV=2	0.035	1.289	2	1	1	1	1347	146	9.19		1				1				171093.625	170926.25	120687.4844		1	1	1			nucleus		"Pf08729, Pf14075"	254048	ENSG00000157741.14	UBN2	7			0
Medium	Q14558	Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2	0.015	1.69	4	1	1	1	356	39.4	7.2				1				1	67194.9375		133686.2188	200785.625	1		1	1		metabolic process;regulation of biological process		catalytic activity;enzyme regulator activity;metal ion binding;protein binding	"Pf13793, Pf14572"	5635		PRPSAP1	17			0
High	Q15645	Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2	0.001	2.84	3	1	1	1	432	48.5	6.09				1				1										cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;nucleotide binding;protein binding;RNA binding	"Pf00004, Pf00910, Pf02367, Pf05496, Pf06068, Pf07726, Pf07728, Pf13191, Pf13207, Pf13238, Pf13401, Pf13521, Pf13671"	9319	ENSG00000071539.13	TRIP13	5			0
Medium	Q9UL63	Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2	0.015	1.704	2	1	1	1	735	84.7	6.34			1				1											cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytosol	protein binding	"Pf00754, Pf01344, Pf06588, Pf13415, Pf13418"	4289	ENSG00000128585.17	MKLN1	7			0
High	O00165	HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2	0.003	2.509	4	1	1	1	279	31.6	4.92				1				1			149773.9531	446277.2188			1	1		cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus	protein binding		10456	ENSG00000143575.14	HAX1	1			0
High	Q3MHD2	Protein LSM12 homolog OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2	0.004	2.359	12	1	1	1	195	21.7	7.74	1				1																Pf09793	124801; 653122	ENSG00000161654.9	LSM12; LSM12P1	17; 8			0
High	Q6PK18	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=OGFOD3 PE=1 SV=2	0.001	3.256	4	1	1	1	319	35.6	8.18				1				1				362774.9688				1		metabolic process	membrane	catalytic activity;metal ion binding	Pf13640	79701	ENSG00000181396.12	OGFOD3	17			0
Medium	Q92560	Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2	0.036	1.246	2	1	1	1	729	80.3	6.84			1				1			281137.1563	385323.6875	1178770.125		1	1	1		cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	Pf01088	8314	ENSG00000163930.9	BAP1	3	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; UCH proteinases		0
Medium	P23921	Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1	0.023	1.406	2	1	1	1	792	90	7.15		1				1												metabolic process	cytoplasm;cytosol	catalytic activity;nucleotide binding;protein binding	"Pf00317, Pf02867, Pf03477"	6240	ENSG00000167325.14	RRM1	11	Interconversion of nucleotide di- and triphosphates	Glutathione metabolism; Purine metabolism; Metabolic pathways; Pyrimidine metabolism	0
Medium	Q13895	Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3	0.022	1.43	3	1	1	1	437	49.6	8.12			1				1			95350.79688	140150.6406			1	1			cell differentiation;cell proliferation;metabolic process	cytoplasm;cytosol;membrane;nucleus	protein binding;RNA binding	Pf05291	705	ENSG00000112578.9	BYSL	6	Major pathway of rRNA processing in the nucleolus and cytosol		0
Medium	Q8IV08	5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1	0.015	1.661	2	1	1	1	490	54.7	6.47				1				1		166909.75		776449.8125		1		1		metabolic process	endoplasmic reticulum;membrane	catalytic activity;protein binding	"Pf00614, Pf13091, Pf13918"	23646	ENSG00000105223.19	PLD3	19	Synthesis of PG; Role of phospholipids in phagocytosis	Ether lipid metabolism; Glycerophospholipid metabolism; Metabolic pathways	0
High	Q96IJ6	Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1	0.004	2.225	2	1	1	1	420	46.3	7.21				1				1	159391.8125	159205.0156	156162.6094	473693.6563	1	1	1	1		metabolic process	cytoplasm	catalytic activity;protein binding	"Pf00132, Pf00483, Pf12804"	29926	ENSG00000144591.18	GMPPA	2	Synthesis of GDP-mannose	Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways	0
High	O43167	Zinc finger and BTB domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ZBTB24 PE=1 SV=2	0	3.442	2	1	1	1	697	78.2	7.61			1				1		74512.24219	656419.3125	1161264	772734.625	1	1	1	1		cell differentiation;metabolic process;regulation of biological process	nucleus	DNA binding;metal ion binding;protein binding	"Pf00096, Pf00651, Pf13465"	9841	ENSG00000112365.4	ZBTB24	6			0
High	Q92542	Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2	0	4.215	2	1	1	1	709	78.4	5.99				1				1										cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;Golgi;membrane	catalytic activity;protein binding	Pf05450	23385	ENSG00000162736.15	NCSTN	1	Activated NOTCH1 Transmits Signal to the Nucleus; Signaling by NOTCH4; Regulated proteolysis of p75NTR; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NRIF signals cell death from the nucleus; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of the extracellular matrix; Neutrophil degranulation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Nuclear signaling by ERBB4; Signalling by NGF	Alzheimer's disease; Notch signaling pathway	0
Low	P17405	Sphingomyelin phosphodiesterase OS=Homo sapiens OX=9606 GN=SMPD1 PE=1 SV=5	0.051	1.093	2	1	1	1	631	69.9	7.28				1				1				332446.5				1												0
High	Q01650	Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2	0	4.632	3	1	1	1	507	55	7.72				1				1			203398.0938	708818.5			1	1		cell differentiation;cellular component movement;development;metabolic process;transport	cytoplasm;cytosol;membrane	protein binding;transporter activity	"Pf00324, Pf13520"	8140	ENSG00000103257.8	SLC7A5	16	Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane	Central carbon metabolism in cancer; mTOR signaling pathway	0
Medium	Q8N6R0	eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=EEF1AKNMT PE=1 SV=1	0.044	1.141	1	1	1	1	699	78.7	6.73			1				1				219587.9063	172432.5156			1	1		metabolic process		catalytic activity;protein binding	"Pf01564, Pf08241, Pf12847, Pf13649, Pf13659, Pf13847"	51603	ENSG00000010165.19	METTL13	1			0
High	O60513	"Beta-1,4-galactosyltransferase 4 OS=Homo sapiens OX=9606 GN=B4GALT4 PE=1 SV=1"	0.004	2.237	5	1	1	1	344	40	9.07				1				1										metabolic process	Golgi;membrane	catalytic activity;metal ion binding	"Pf02709, Pf10111, Pf13733"	8702	ENSG00000121578.12	B4GALT4	3	Keratan sulfate biosynthesis; N-Glycan antennae elongation	Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways; Glycosaminoglycan biosynthesis - keratan sulfate	0
Low	O43295	SLIT-ROBO Rho GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=SRGAP3 PE=1 SV=3	0.056	1.041	1	1	1	1	1099	124.4	6.68				1				1		180502.8438	224725.3281	248467.3906		1	1	1		regulation of biological process;response to stimulus	cytoplasm;cytosol	enzyme regulator activity;protein binding	"Pf00018, Pf00611, Pf00620, Pf07653, Pf14604"	9901	ENSG00000196220.15	SRGAP3	3	Inactivation of CDC42 and RAC1; Rho GTPase cycle	Axon guidance	0
High	Q8NAT1	"Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=POMGNT2 PE=1 SV=1"	0.004	2.299	2	1	1	1	580	66.6	8.57			1				1			91547.64063	542293.375	395513.5		1	1	1		cellular component movement;metabolic process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf04577	84892	ENSG00000144647.5	GTDC2; POMGNT2	3	O-linked glycosylation		0
High	P11177	"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3"	0.001	3.394	3	1	1	1	359	39.2	6.65				1				1	120733.0078	177702	429042.0313	624763.4375	1	1	1	1		metabolic process;regulation of biological process	mitochondrion;nucleus;organelle lumen	catalytic activity;protein binding	"Pf02779, Pf02780"	5162	ENSG00000168291.12	PDHB	3	Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation	Citrate cycle (TCA cycle); HIF-1 signaling pathway; Central carbon metabolism in cancer; Carbon metabolism; Pyruvate metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways	0
High	Q3ZCQ8	Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2	0.006	1.93	2	1	1	1	353	39.6	8.37				1				1	59111.11719	115391.5		326216.9688	1	1		1		cell organization and biogenesis;metabolic process;transport	membrane;mitochondrion;nucleus	catalytic activity;protein binding;RNA binding	Pf03031	92609	ENSG00000105197.10	TIMM50	19	Mitochondrial protein import; Metabolism of proteins		0
High	Q9P246	Stromal interaction molecule 2 OS=Homo sapiens OX=9606 GN=STIM2 PE=1 SV=2	0.005	2.009	2	1	1	1	746	83.9	6.76			1				1											cellular homeostasis;regulation of biological process;transport	endoplasmic reticulum;membrane	metal ion binding;protein binding;transporter activity	"Pf00536, Pf07647"	57620	ENSG00000109689.15	STIM2	4		Calcium signaling pathway	0
Medium	P25787	Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2	0.03	1.318	3	1	1	1	234	25.9	7.43		1				1			72293.15625	145188.5781	123645.2422	272892.0313	1	1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome	catalytic activity;protein binding	"Pf00227, Pf10584"	5683	ENSG00000256646.7; ENSG00000106588.10	PSMA2	7	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	Proteasome	0
High	Q96L15	Ecto-ADP-ribosyltransferase 5 OS=Homo sapiens OX=9606 GN=ART5 PE=2 SV=4	0.007	1.923	4	1	1	1	291	32	8.27			1				1				302578.1875	477041			1	1		metabolic process	extracellular;membrane	catalytic activity	Pf01129	116969	ENSG00000167311.13	ART5	11			0
Medium	Q9H078	Caseinolytic peptidase B protein homolog OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1	0.015	1.684	1	1	1	1	707	78.7	9.01	1				1				213948.3906	46753.72656	130720.1094	116434.4609	1	1	1	1		response to stimulus	mitochondrion	catalytic activity;nucleotide binding;protein binding	"Pf00004, Pf00023, Pf06309, Pf06414, Pf07724, Pf07728, Pf10431, Pf12796, Pf13401, Pf13606, Pf13637, Pf13857"	81570	ENSG00000162129.12	CLPB	11		Longevity regulating pathway - multiple species	0
Medium	Q92600	CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1	0.022	1.469	3	1	1	1	299	33.6	8.03	1				1				308554.5313	151704.2344	263717.3438		1	1	1			metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	protein binding	Pf04078	9125	ENSG00000144580.13	RQCD1; CNOT9	2	Activation of anterior HOX genes in hindbrain development during early embryogenesis; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA	RNA degradation	0
High	Q8NI60	"Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1"	0.004	2.163	2	1	1	1	647	71.9	6.99				1				1				247884.7344				1		metabolic process	membrane;mitochondrion	catalytic activity;nucleotide binding;protein binding	Pf03109	56997	ENSG00000163050.16	ADCK3; COQ8A	1			0
Low	Q8ND56	Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3	0.055	1.048	2	1	1	1	463	50.5	9.52		1				1												cell organization and biogenesis;defense response;development;regulation of biological process;response to stimulus	cytoplasm;cytosol	DNA binding;RNA binding	"Pf09532, Pf12701, Pf14438"	26065	ENSG00000262860.5; ENSG00000257103.8	LSM14A	19; CHR_HSCHR19_1_CTG3_1			0
Medium	O43819	"Protein SCO2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3"	0.019	1.561	3	1	1	1	266	29.8	8.85				1				1										cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport	membrane;mitochondrion;organelle lumen	antioxidant activity;catalytic activity;metal ion binding;protein binding	"Pf00578, Pf02630, Pf13905"	9997	ENSG00000130489.14; ENSG00000284194.1	SCO2	22	TP53 Regulates Metabolic Genes; Respiratory electron transport	Central carbon metabolism in cancer	0
High	Q6PKG0	La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2	0.007	1.89	1	1	1	1	1096	123.4	8.82				1				1		61184.75391		89867.19531		1		1		cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;membrane	protein binding;RNA binding;translation regulator activity	Pf05383	23367		LARP1	5			0
Medium	Q9NX63	MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1	0.015	1.659	4	1	1	1	227	26.1	8.28			1				1				235402.9531				1			cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;membrane;mitochondrion;nucleus	protein binding;structural molecule activity	"Pf05300, Pf06747"	54927	ENSG00000106554.11	CHCHD3	7	Cristae formation; Mitochondrial protein import; Metabolism of proteins		0
Low	Q9P109	"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 OS=Homo sapiens OX=9606 GN=GCNT4 PE=2 SV=1"	0.054	1.071	4	1	1	1	453	53	8.25			1				1			3014687.75	3622488.5	3749020		1	1	1		metabolic process;response to stimulus	Golgi;membrane	catalytic activity	Pf02485	51301	ENSG00000176928.5	GCNT4	5	O-linked glycosylation of mucins	Mucin type O-glycan biosynthesis; Metabolic pathways	0
High	P61077	Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1	0.004	2.369	16	1	1	1	147	16.7	7.8			1				1			93057.41406	583549.8125			1	1			cell death;metabolic process;regulation of biological process;response to stimulus	cytosol;endosome;membrane	catalytic activity;nucleotide binding;protein binding	"Pf00179, Pf14461"	7323	ENSG00000109332.19	UBE2D3	4	"IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Activated TLR4 signalling; Signaling by BMP; E3 ubiquitin ligases ubiquitinate target proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Negative regulators of DDX58/IFIH1 signaling"	Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum	0
Medium	Q96S59	Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1	0.041	1.203	2	1	1	1	729	77.8	6.79	1				1				276258.9688				1					cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	protein binding	"Pf00622, Pf08513, Pf10607"	10048	ENSG00000010017.12	RANBP9	6	L1CAM interactions; RAF/MAP kinase cascade; MET activates RAS signaling; Interleukin-20 family signaling		0
Low	Q9BW92	"Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1"	0.052	1.089	1	1	1	1	718	81	7.3				1				1	94511.07031	98189.74219	162211.3125	216499.1563	1	1	1	1		metabolic process;regulation of biological process	cytoplasm;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding	"Pf00587, Pf02824, Pf03129, Pf07973"	80222	ENSG00000143374.16	TARS2	1	Mitochondrial tRNA aminoacylation	Aminoacyl-tRNA biosynthesis	0
Medium	Q13685	Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2	0.021	1.484	3	1	1	1	434	46.7	4.42				1				1	120082.7578			492282.4375	1			1		cell differentiation;cellular component movement;development;regulation of biological process	cell surface;cytoplasm;cytoskeleton;cytosol;membrane	protein binding	"Pf00400, Pf14134"	14	ENSG00000127837.9	AAMP	2			0
Medium	Q8IXI1	Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2	0.022	1.429	1	1	1	1	618	68.1	5.86			1				1			77911.51563	144720.5	231634.5469		1	1	1		cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport	cytosol;membrane;mitochondrion	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00071, Pf01926, Pf08355, Pf08356, Pf08477, Pf13479"	89941	ENSG00000140983.13	RHOT2	16	Rho GTPase cycle		0
Medium	P51648	Aldehyde dehydrogenase family 3 member A2 OS=Homo sapiens OX=9606 GN=ALDH3A2 PE=1 SV=1	0.033	1.293	3	1	1	1	485	54.8	7.88				1				1				122985.8125				1		metabolic process	endoplasmic reticulum;membrane;mitochondrion	catalytic activity	Pf00171	224	ENSG00000072210.18	ALDH3A2	17	Sphingolipid de novo biosynthesis	"Fatty acid degradation; Ascorbate and aldarate metabolism; Lysine degradation; Histidine metabolism; beta-Alanine metabolism; Pyruvate metabolism; Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Pentose and glucuronate interconversions; Metabolic pathways; Tryptophan metabolism; Arginine and proline metabolism; Valine, leucine and isoleucine degradation"	0
High	Q92521	GPI mannosyltransferase 3 OS=Homo sapiens OX=9606 GN=PIGB PE=1 SV=1	0.003	2.436	2	1	1	1	554	65	9.29				1				1										metabolic process	endoplasmic reticulum;membrane	catalytic activity	Pf03901	9488	ENSG00000069943.9	PIGB	15	Synthesis of glycosylphosphatidylinositol (GPI)	Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0
Low	Q5VSG8	"Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=2 SV=1"	0.052	1.084	2	1	1	1	457	51.3	6.98				1				1				349040.875				1			Golgi;membrane	catalytic activity		149175	ENSG00000185090.14	MANEAL	1			0
Medium	Q9H329	Band 4.1-like protein 4B OS=Homo sapiens OX=9606 GN=EPB41L4B PE=2 SV=2	0.044	1.148	1	1	1	1	900	99.7	9.04	1				1				123062.1641	105369.4766		91926.29688	1	1		1		cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;structural molecule activity	"Pf00373, Pf08736, Pf09379, Pf09380"	54566	ENSG00000095203.14	EPB41L4B	9			0
High	Q9NU22	Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2	0.003	2.474	0	1	1	1	5596	632.4	5.68				1				1		65905.74219	64429.76172	172498.0469		1	1	1		cell organization and biogenesis;metabolic process	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding	"Pf00004, Pf00092, Pf02367, Pf07726, Pf07728, Pf13401, Pf13671"	23195	ENSG00000112159.11	MDN1	6		Ribosome biogenesis in eukaryotes	0
Medium	Q13283	Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1	0.021	1.519	2	1	1	1	466	52.1	5.52				1				1	195332.3438	259967.8438	230607.2188	223252.5156	1	1	1	1		metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;nucleus	catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding	"Pf00076, Pf02136, Pf13893, Pf14259"	10146	ENSG00000145907.14	G3BP1	5			0
High	Q6P2E9	Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1	0	4.423	1	1	1	1	1401	151.6	5.86	1				1													metabolic process	cytoplasm;cytosol;membrane;nucleus	protein binding	Pf00400	23644	ENSG00000038358.14	EDC4	16	mRNA decay by 5' to 3' exoribonuclease	RNA degradation	0
Medium	Q8WUM0	Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2	0.041	1.197	1	1	1	1	1156	128.9	5.1			1				1		53189.75781	60928.63281	156266.4219	168317.0625	1	1	1	1		cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport	chromosome;cytosol;membrane;nucleus	protein binding;structural molecule activity;transporter activity	"Pf03177, Pf08801"	55746	ENSG00000069248.11	NUP133	1	Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins	RNA transport	0
High	P07711	Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2	0.001	2.95	4	1	1	1	333	37.5	5.45				1				1	326316.5625	524319.75		1284580.625	1	1		1		cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular;nucleus;organelle lumen;vacuole	catalytic activity;protein binding	"Pf00112, Pf08246"	1514	ENSG00000135047.14	CTSL; CTSL1	9	Collagen degradation; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Assembly of collagen fibrils and other multimeric structures; Endosomal/Vacuolar pathway; MHC class II antigen presentation; Trafficking and processing of endosomal TLR	Lysosome; Phagosome; Apoptosis; Proteoglycans in cancer; Antigen processing and presentation; Rheumatoid arthritis	0
Medium	O60343	TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2	0.011	1.836	1	1	1	1	1298	146.5	7.01		1				1			84192.82813	226828.7969	220569.0469	292721.3125	1	1	1	1		cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane	enzyme regulator activity;protein binding	"Pf00566, Pf00640, Pf11830"	9882	ENSG00000136111.12	TBC1D4	13	Translocation of GLUT4 to the plasma membrane	Thyroid hormone signaling pathway; Insulin resistance	0
High	Q8WWB7	Glycosylated lysosomal membrane protein OS=Homo sapiens OX=9606 GN=GLMP PE=1 SV=1	0	3.619	5	1	1	1	406	43.8	6.58				1				1										regulation of biological process;response to stimulus	cytosol;membrane;nucleus;vacuole	DNA binding	Pf15065	112770	ENSG00000198715.11	C1orf85; GLMP	1			0
High	Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens OX=9606 GN=CAMK2A PE=1 SV=2	0.006	1.963	2	1	1	1	478	54.1	7.08			1				1		180463.6563	144743.4063	284016.2188		1	1	1			cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus	catalytic activity;metal ion binding;nucleotide binding;protein binding	"Pf00069, Pf07714, Pf08332, Pf13474, Pf14534"	815	ENSG00000070808.15	CAMK2A	5	"Ion homeostasis; HSF1-dependent transactivation; Interferon gamma signaling; Ca2+ pathway; Phase 0 - rapid depolarisation; Ras activation uopn Ca2+ infux through NMDA receptor; Ion transport by P-type ATPases; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of AMPA receptors; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling"	Dopaminergic synapse; HIF-1 signaling pathway; Amphetamine addiction; Neurotrophin signaling pathway; Oxytocin signaling pathway; Olfactory transduction; Circadian entrainment; ErbB signaling pathway; Long-term potentiation; Insulin secretion; Glioma; Adrenergic signaling in cardiomyocytes; Tuberculosis; Glucagon signaling pathway; Melanogenesis; Wnt signaling pathway; Proteoglycans in cancer; Aldosterone synthesis and secretion; Oocyte meiosis; Gastric acid secretion; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Axon guidance; cAMP signaling pathway; Cholinergic synapse; Calcium signaling pathway	0
Medium	Q9Y399	"28S ribosomal protein S2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1"	0.017	1.629	2	1	1	1	296	33.2	9.26				1				1	109639.5	128362.8516	121750.1563	195755.9844	1	1	1	1		cell organization and biogenesis;metabolic process	membrane;mitochondrion;ribosome	structural molecule activity	Pf00318	51116	ENSG00000122140.10	MRPS2	9	Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination	Ribosome	0
High	Q92830	Histone acetyltransferase KAT2A OS=Homo sapiens OX=9606 GN=KAT2A PE=1 SV=3	0.007	1.924	1	1	1	1	837	93.9	9.04		1				1			45317.24219	208203.9688	228475.75	94330.95313	1	1	1	1		cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	nucleus	catalytic activity;protein binding	"Pf00439, Pf00583, Pf06466, Pf13508, Pf13673"	2648	ENSG00000108773.10	KAT2A	17	NOTCH1 Intracellular Domain Regulates Transcription; Ub-specific processing proteases; HATs acetylate histones; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Pre-NOTCH Transcription and Translation; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation	Viral carcinogenesis; Thyroid hormone signaling pathway; HTLV-I infection; Notch signaling pathway	0
Low	O94952	F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21 PE=2 SV=2	0.059	0.966	1	1	1	1	628	72.2	6.09				1				1		142325.9688	136839.5625	269203.5313		1	1	1		metabolic process	cytosol	catalytic activity;DNA binding;protein binding	"Pf08755, Pf12937, Pf13369"	23014	ENSG00000135108.14	FBXO21	12	Antigen processing: Ubiquitination & Proteasome degradation; Neddylation		0
Medium	Q13217	DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1	0.041	1.196	2	1	1	1	504	57.5	6.15				1				1	64634.15625			318809.75	1			1		defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;organelle lumen	enzyme regulator activity;protein binding	"Pf00226, Pf00515, Pf12569, Pf13371, Pf13414, Pf13432, Pf14559"	5611	ENSG00000102580.14	DNAJC3	13	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Viral mRNA Translation; Neutrophil degranulation; XBP1(S) activates chaperone genes	Protein processing in endoplasmic reticulum; Influenza A	0
High	Q5NDL2	EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1	0.005	2.084	3	1	1	1	527	62	7.05				1				1				126114.9766				1		metabolic process	endoplasmic reticulum;organelle lumen	catalytic activity	Pf04577	285203	ENSG00000163378.13	EOGT	3		Other types of O-glycan biosynthesis	0
Medium	Q15054	DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2	0.022	1.463	3	1	1	1	466	51.4	9.35				1				1										cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus	cytoplasm;nucleus	catalytic activity;protein binding;RNA binding	"Pf08597, Pf09507"	10714	ENSG00000077514.8	POLD3	11	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Termination of translesion DNA synthesis; Recognition of DNA damage by PCNA-containing replication complex; Polymerase switching on the C-strand of the telomere; Dual incision in TC-NER; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate from the C-strand	Homologous recombination; DNA replication; Purine metabolism; Mismatch repair; Base excision repair; HTLV-I infection; Nucleotide excision repair; Metabolic pathways; Pyrimidine metabolism	0
High	O15269	Serine palmitoyltransferase 1 OS=Homo sapiens OX=9606 GN=SPTLC1 PE=1 SV=1	0.001	3.099	3	1	1	1	473	52.7	6.01			1				1											metabolic process	endoplasmic reticulum;membrane	catalytic activity;protein binding	Pf00155	10558	ENSG00000090054.13	SPTLC1	9	Sphingolipid de novo biosynthesis	Sphingolipid metabolism; Sphingolipid signaling pathway; Metabolic pathways	0
Medium	A2RU67	Protein FAM234B OS=Homo sapiens OX=9606 GN=FAM234B PE=1 SV=1	0.011	1.847	1	1	1	1	622	67	5.02				1				1				406870.3438				1			membrane		Pf13360	57613	ENSG00000084444.13	KIAA1467; FAM234B	12			0
Low	Q9HC07	Transmembrane protein 165 OS=Homo sapiens OX=9606 GN=TMEM165 PE=1 SV=1	0.052	1.08	8	1	1	1	324	34.9	7.02				1				1										cellular homeostasis;metabolic process;transport	endosome;Golgi;membrane;vacuole		Pf01169	55858	ENSG00000134851.12	TMEM165	4			0
High	P43490	Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1	0.001	3.219	4	1	1	1	491	55.5	7.15				1				1			180072.5625	459847.6563			1	1		cell communication;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;extracellular;nucleus	catalytic activity;protein binding	Pf04095	10135	ENSG00000105835.11	NAMPT	7	"BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging"	NOD-like receptor signaling pathway; Nicotinate and nicotinamide metabolism; Metabolic pathways	0
Medium	O43448	Voltage-gated potassium channel subunit beta-3 OS=Homo sapiens OX=9606 GN=KCNAB3 PE=1 SV=2	0.033	1.303	8	1	1	1	404	43.6	8.6	1				1				548142.1875				1					regulation of biological process;transport	cytoplasm;membrane	transporter activity	Pf00248	9196	ENSG00000170049.9	KCNAB3	17	Voltage gated Potassium channels		0
High	O00330	"Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3"	0.007	1.878	2	1	1	1	501	54.1	8.66	1				1				222332.4219		109286.0391		1		1			metabolic process;regulation of biological process	mitochondrion;organelle lumen	catalytic activity;protein binding	"Pf00198, Pf00364, Pf02817"	8050	ENSG00000110435.11	PDHX	11	Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation	Metabolic pathways	0