Protein FDR Confidence: Combined Accession Description Exp. q-value: Combined Sum PEP Score Coverage [%] # Peptides # PSMs # Unique Peptides # AAs MW [kDa] calc. pI # Peptides (by Search Engine): A2 Sequest HT (IgG Adipo) # Peptides (by Search Engine): B2 Sequest HT (SelL -/- Adipo) # Peptides (by Search Engine): C2 Sequest HT # Peptides (by Search Engine): D2 Sequest HT (Hrd1 -/- Adipo) # PSMs (by Search Engine): A2 Sequest HT (IgG Adipo) # PSMs (by Search Engine): B2 Sequest HT (SelL -/- Adipo) # PSMs (by Search Engine): C2 Sequest HT # PSMs (by Search Engine): D2 Sequest HT (Hrd1 -/- Adipo) "Abundance: F1: Sample, IgG Adipo" "Abundance: F2: Sample, SelL -/- Adipo" "Abundance: F3: Sample, WT Adipo" "Abundance: F4: Sample, Hrd1 -/- Adipo" "Abundances Count: F1: Sample, IgG Adipo" "Abundances Count: F2: Sample, SelL -/- Adipo" "Abundances Count: F3: Sample, WT Adipo" "Abundances Count: F4: Sample, Hrd1 -/- Adipo" Modifications Biological Process Cellular Component Molecular Function Pfam IDs Entrez Gene ID Ensembl Gene ID Gene Symbol Chromosome Reactome Pathways KEGG Pathways # Razor Peptides High J3QJX3 Protein sel-1 homolog 1 OS=Mus musculus OX=10090 GN=Sel1l PE=1 SV=1 0 891.226 75 43 1287 43 740 82.4 6.02 1 23 29 43 1 108 180 998 75709626.03 833943121 1507733625 10696251902 17 61 65 81 metabolic process;response to stimulus;transport protein binding Pf08238 ENSMUSG00000020964.14 12 0 High E9PZ16 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Mus musculus OX=10090 GN=Hspg2 PE=1 SV=1 0 1075.733 53 152 1085 152 4383 469.5 6.47 93 141 128 118 170 365 312 238 741809588.7 1206090612 1275179319 1217244888 140 158 154 142 cell differentiation;cell organization and biogenesis;transport extracellular metal ion binding;protein binding "Pf00008, Pf00047, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf07686, Pf12785, Pf13385, Pf13895, Pf13927" 15530 ENSMUSG00000028763.17 Hspg2 4 HS-GAG degradation; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Signaling by GPCR; Retinoid metabolism and transport; Integrin cell surface interactions; HS-GAG biosynthesis; Non-integrin membrane-ECM interactions Hepatitis B; Proteoglycans in cancer; ECM-receptor interaction 0 High P08113 Endoplasmin OS=Mus musculus OX=10090 GN=Hsp90b1 PE=1 SV=2 0 713.09 71 68 865 66 802 92.4 4.82 15 23 21 68 23 38 34 770 178467050 250352608.8 193081948.5 10678005589 43 53 47 95 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 22027 ENSMUSG00000020048.13 Hsp90b1 10 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR Thyroid hormone synthesis; Pathways in cancer; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Prostate cancer 4 High Q8K2C7 Protein OS-9 OS=Mus musculus OX=10090 GN=Os9 PE=1 SV=2 0 697.414 78 61 797 61 672 76.1 4.84 30 36 61 82 123 592 3651239.66 361925070.4 603672349.7 7374150506 9 54 53 79 metabolic process;response to stimulus;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 216440 ENSMUSG00000040462.13 Os9 10 Hedgehog ligand biogenesis; ABC-family proteins mediated transport; ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High P20029 Endoplasmic reticulum chaperone BiP OS=Mus musculus OX=10090 GN=Hspa5 PE=1 SV=3 0 422.279 62 51 445 49 655 72.4 5.16 34 34 27 50 76 69 42 258 158071710.8 274568355.2 113516017.6 2819591006 44 51 38 61 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endoplasmic reticulum;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00012, Pf01968, Pf06723" 14828 ENSMUSG00000026864.13 Hspa5 2 Thyroid hormone synthesis; Antigen processing and presentation; Protein export; Prion diseases; Protein processing in endoplasmic reticulum 2 High Q8VEH8 Endoplasmic reticulum lectin 1 OS=Mus musculus OX=10090 GN=Erlec1 PE=1 SV=1 0 443.459 81 32 434 32 483 54.9 6.25 25 28 32 94 126 214 1951322.266 458537530.6 701397100.9 2151409330 5 43 44 46 metabolic process;transport endoplasmic reticulum;organelle lumen protein binding "Pf07915, Pf13015" 66753 ENSMUSG00000020311.17 Erlec1 11 Hedgehog ligand biogenesis; ABC-family proteins mediated transport Protein processing in endoplasmic reticulum 0 High Q8BMS1 "Trifunctional enzyme subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Hadha PE=1 SV=1" 0 465.023 67 43 421 43 763 82.6 9.14 23 31 31 43 46 80 71 224 135437969.9 335824360.8 276263997.7 2060927989 45 52 53 63 metabolic process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00378, Pf00725, Pf02737" 97212 ENSMUSG00000025745.11 Hadha 5 Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; beta-Alanine metabolism; Propanoate metabolism; Fatty acid elongation; Carbon metabolism; Biosynthesis of unsaturated fatty acids" 0 High Q8R0Y6 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Mus musculus OX=10090 GN=Aldh1l1 PE=1 SV=1 0 414.136 81 63 409 58 902 98.6 5.91 60 55 57 141 136 132 1287915.289 636283279.1 565514234.9 620591599.1 6 65 60 63 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;protein binding "Pf00171, Pf00550, Pf00551, Pf02911" 107747 ENSMUSG00000030088.15 Aldh1l1 6 Metabolism of folate and pterines One carbon pool by folate 5 High F6SMY7 E3 ubiquitin-protein ligase MYCBP2 (Fragment) OS=Mus musculus OX=10090 GN=Mycbp2 PE=1 SV=1 0 505.036 33 123 402 123 4636 509 7.09 98 83 92 148 122 132 13492697.16 266210497 222452544.5 230696082.9 16 115 112 112 metal ion binding;protein binding "Pf00415, Pf00630, Pf08005, Pf08239, Pf13540, Pf13639, Pf13923" ENSMUSG00000033004.14 14 0 High P38647 "Stress-70 protein, mitochondrial OS=Mus musculus OX=10090 GN=Hspa9 PE=1 SV=3" 0 318.421 56 41 367 40 679 73.4 6.07 33 33 33 39 88 82 80 117 377300577.3 507814267.5 426140825 745734728.3 47 48 48 49 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;mitochondrion;nucleus;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00012, Pf06723" 15526 ENSMUSG00000024359.8 Hspa9 18 RNA degradation; Tuberculosis 1 High Q8BWT1 "3-ketoacyl-CoA thiolase, mitochondrial OS=Mus musculus OX=10090 GN=Acaa2 PE=1 SV=3" 0 486.919 83 31 327 31 397 41.8 8.09 16 21 21 31 28 47 58 194 61414282.98 167800135.1 171397079.7 2336446757 23 31 29 43 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;RNA binding "Pf00108, Pf02801, Pf02803" 52538 ENSMUSG00000036880.9 Acaa2 18 Mitochondrial Fatty Acid Beta-Oxidation "Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; Fatty acid elongation" 0 High Q99JY0 "Trifunctional enzyme subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Hadhb PE=1 SV=1" 0 277.031 71 32 266 32 475 51.4 9.38 16 19 22 32 32 51 47 136 61006971.93 183873893 153404101.4 976679274.8 27 33 32 38 metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00108, Pf00109, Pf02803" 231086 ENSMUSG00000059447.13 Hadhb 5 Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; Fatty acid elongation" 0 High E9PUQ5 Golgin subfamily A member 2 OS=Mus musculus OX=10090 GN=Golga2 PE=1 SV=1 0 305.274 46 42 245 42 1026 116.2 5.05 41 38 38 87 73 85 16202862.28 428058116.4 327265253.6 455330161.7 4 49 48 47 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi;membrane;nucleus protein binding "Pf12128, Pf15070" 99412 ENSMUSG00000002546.16 Golga2 2 0 High Q5SWU9 Acetyl-CoA carboxylase 1 OS=Mus musculus OX=10090 GN=Acaca PE=1 SV=1 0 310.103 34 64 231 55 2345 265.1 6.39 2 48 37 58 2 73 59 97 8534941.055 101682275.9 93486373.39 197198128.8 20 57 55 61 Acetyl [N-Term] cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;cytosol;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf01039, Pf02222, Pf02655, Pf02785, Pf02786, Pf07478, Pf08326, Pf13535, Pf15632" 107476 ENSMUSG00000020532.18 Acaca 11 ChREBP activates metabolic gene expression; Biotin transport and metabolism; Fatty acyl-CoA biosynthesis; Import of palmitoyl-CoA into the mitochondrial matrix Fatty acid metabolism; Pyruvate metabolism; Insulin signaling pathway; Metabolic pathways; Propanoate metabolism; AMPK signaling pathway; Fatty acid biosynthesis; Glucagon signaling pathway 10 High P63017 Heat shock cognate 71 kDa protein OS=Mus musculus OX=10090 GN=Hspa8 PE=1 SV=1 0 183.87 48 29 229 24 646 70.8 5.52 20 27 26 27 34 58 60 77 47291644.16 155791770.2 137199121.9 237359352.9 29 30 30 31 cell organization and biogenesis;metabolic process;regulation of biological process;transport cell surface;cytoplasm;cytosol;endosome;membrane;nucleus;spliceosomal complex;vacuole catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00012, Pf02463, Pf06723" 15481 ENSMUSG00000015656.17 Hspa8 9 "Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; mRNA Splicing - Major Pathway; Attenuation phase; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; GABA synthesis, release, reuptake and degradation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Protein methylation; Clathrin-mediated endocytosis" Endocytosis; MAPK signaling pathway; Toxoplasmosis; Epstein-Barr virus infection; Spliceosome; Legionellosis; Influenza A; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Measles; Longevity regulating pathway - multiple species 2 High P16858 Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus OX=10090 GN=Gapdh PE=1 SV=2 0 233.412 74 22 218 19 333 35.8 8.25 11 15 14 22 18 43 35 122 37132821.8 145239742.2 106836826.7 877608218.7 21 27 26 33 Met-loss [N-Term] cell death;cell organization and biogenesis;defense response;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;enzyme regulator activity;nucleotide binding;protein binding "Pf00044, Pf02800" 14433; 100042025; 100042746 ENSMUSG00000057666.18 Gapdh; Gm20899; LOC100042025; Gapdh-ps15; Gm12033 6; Y; 11 Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Alzheimer's disease; Carbon metabolism 4 High G5E8R3 Pyruvate carboxylase OS=Mus musculus OX=10090 GN=Pcx PE=1 SV=1 0 269.591 54 46 211 46 1178 129.6 6.71 12 30 29 44 18 51 48 94 27072035.2 114216002.9 116458680.3 410741933.5 30 37 38 46 metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf00682, Pf02222, Pf02436, Pf02785, Pf02786, Pf07478, Pf08443, Pf13533, Pf13535, Pf15632" 18563 ENSMUSG00000024892.15 Pcx 19 Biotin transport and metabolism; Gluconeogenesis 0 High P12382 "ATP-dependent 6-phosphofructokinase, liver type OS=Mus musculus OX=10090 GN=Pfkl PE=1 SV=4" 0 301.144 56 33 202 28 780 85.3 7.17 5 18 17 33 7 28 30 137 15075722.7 58149631.63 73102979.3 641116460.1 17 27 32 44 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 18641 ENSMUSG00000020277.10 Pfkl 10 Neutrophil degranulation; Glycolysis RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Pentose phosphate pathway; HIF-1 signaling pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 9 High P68372 Tubulin beta-4B chain OS=Mus musculus OX=10090 GN=Tubb4b PE=1 SV=1 0 226.942 69 25 198 1 445 49.8 4.89 5 13 16 25 6 24 34 134 54364144 200315372.1 204475915.8 285072912 4 4 4 5 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;RNA binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 227613 ENSMUSG00000036752.4 Tubb4b 2 Anchoring of the basal body to the plasma membrane; Intraflagellar transport; Hedgehog 'on' state; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Hedgehog 'off' state; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes Phagosome; Gap junction 3 High P99024 Tubulin beta-5 chain OS=Mus musculus OX=10090 GN=Tubb5 PE=1 SV=1 0 236.823 73 26 193 4 444 49.6 4.89 5 11 17 26 6 20 37 130 13758344.11 61518130.3 81173624.55 477232800 16 22 29 35 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 22154 ENSMUSG00000001525.10 Tubb5 17 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes Phagosome; Gap junction 31 High Q91VA7 "Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Mus musculus OX=10090 GN=Idh3b PE=1 SV=1" 0 203.354 58 26 193 26 384 42.2 8.6 13 18 20 25 18 33 38 104 37068188.84 98177392.09 115667676.4 1071467083 20 22 25 31 metabolic process mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding Pf00180 170718 ENSMUSG00000027406.12 Idh3b 2 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism 0 High Q69Z38 Inactive tyrosine-protein kinase PEAK1 OS=Mus musculus OX=10090 GN=Peak1 PE=1 SV=4 0 261.625 42 51 193 51 1735 191 6.87 44 28 40 77 49 67 31086160.86 167626351.5 120628953.6 169929132.8 9 49 42 45 cell organization and biogenesis;cellular component movement;metabolic process cytoplasm;cytoskeleton catalytic activity;nucleotide binding Pf00069 244895 ENSMUSG00000074305.9 C230081A13Rik; Peak1 9 0 High B7ZWK0 Nek1 protein OS=Mus musculus OX=10090 GN=Nek1 PE=1 SV=1 0 235.625 46 45 188 45 1231 139.6 5.49 37 33 37 64 61 63 1936921.211 169514824.4 154222038.6 192194987.8 4 43 41 40 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 18004 ENSMUSG00000031644.19 Nek1 8 0 High E9QAI5 CAD protein OS=Mus musculus OX=10090 GN=Cad PE=1 SV=1 0 209.995 28 45 178 45 2162 236.1 6.49 2 29 41 35 2 51 75 50 3623972.211 73144280.81 110589788.1 90083143.7 15 43 44 44 metabolic process catalytic activity;metal ion binding;nucleotide binding "Pf00117, Pf00185, Pf00289, Pf00988, Pf01071, Pf01979, Pf02142, Pf02222, Pf02729, Pf02786, Pf02787, Pf07478, Pf07722, Pf08443, Pf13147, Pf13535, Pf13594, Pf15632" ENSMUSG00000013629.16 5 0 High P19324 Serpin H1 OS=Mus musculus OX=10090 GN=Serpinh1 PE=1 SV=3 0 169.567 59 20 169 20 417 46.5 8.82 3 16 14 20 3 50 52 64 4423279.484 150647859.1 191500668.7 365383514.4 9 18 18 21 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;organelle lumen enzyme regulator activity;protein binding;RNA binding Pf00079 12406 ENSMUSG00000070436.12 Serpinh1 7 Collagen biosynthesis and modifying enzymes 0 High Q9D6F9 Tubulin beta-4A chain OS=Mus musculus OX=10090 GN=Tubb4a PE=1 SV=3 0 198.082 62 21 169 1 444 49.6 4.88 4 10 13 21 5 19 28 117 3181335.5 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 22153 ENSMUSG00000062591.5 Tubb4a 17 Anchoring of the basal body to the plasma membrane; Intraflagellar transport; Hedgehog 'on' state; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Hedgehog 'off' state; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes Phagosome; Gap junction 0 High P04104 "Keratin, type II cytoskeletal 1 OS=Mus musculus OX=10090 GN=Krt1 PE=1 SV=4" 0 53.683 8 11 167 6 637 65.6 8.15 7 8 7 10 41 41 46 39 368495115.6 497221882.3 534715343 382162170.3 8 8 8 8 defense response;metabolic process;regulation of biological process;response to stimulus cytoskeleton;membrane;nucleus structural molecule activity "Pf00038, Pf11853" 16678 ENSMUSG00000046834.6 Krt1 15 Formation of the cornified envelope; Neutrophil degranulation 2 High P68373 Tubulin alpha-1C chain OS=Mus musculus OX=10090 GN=Tuba1c PE=1 SV=1 0 162.546 55 20 155 5 449 49.9 5.1 9 15 16 20 11 33 33 78 17395317.51 67983108.47 84042857.13 502822507.8 13 19 20 24 cell organization and biogenesis cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953" 22146 ENSMUSG00000043091.8 Tuba1c 15 Intraflagellar transport; Hedgehog 'on' state; Hedgehog 'off' state Phagosome; Gap junction; Apoptosis 20 High Q9Z2I9 "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Sucla2 PE=1 SV=2" 0 164.362 61 28 153 28 463 50.1 7.01 8 14 17 28 10 23 27 93 16836881.58 65486948.98 85789165.88 691837170.9 15 22 25 32 metabolic process mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf00549, Pf02222, Pf02786, Pf08442, Pf13535, Pf13549" 20916 ENSMUSG00000022110.13 Sucla2 14 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Propanoate metabolism; Carbon metabolism 0 High Q60847 Collagen alpha-1(XII) chain OS=Mus musculus OX=10090 GN=Col12a1 PE=2 SV=3 0 162.957 19 50 151 50 3120 340 5.64 15 45 31 17 21 68 42 20 34512816.52 107976064.3 78629461.09 39036594.02 37 43 41 33 cell differentiation extracellular protein binding "Pf00041, Pf00092, Pf13519" 12816 Col12a1 9 Collagen chain trimerization; Collagen degradation; Assembly of collagen fibrils and other multimeric structures Protein digestion and absorption 0 High Q03265 "ATP synthase subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1a PE=1 SV=1" 0 179.523 61 32 151 32 553 59.7 9.19 7 17 16 31 9 26 30 86 21326504.31 87369925.91 102905971.1 674938335.2 23 27 27 33 metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00006, Pf00306, Pf02663, Pf02874, Pf05943" 11946 ENSMUSG00000025428.15 Atp5a1 18 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q7TMM9 Tubulin beta-2A chain OS=Mus musculus OX=10090 GN=Tubb2a PE=1 SV=1 0 158.75 53 21 148 2 445 49.9 4.89 4 9 14 21 4 14 28 102 508454.5 521353.5 3041373.188 1 1 2 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 22151 ENSMUSG00000058672.6 Tubb2a 13 Intraflagellar transport; Hedgehog 'on' state; Hedgehog 'off' state Phagosome; Gap junction 0 High A0A0A0MQA5 Tubulin alpha chain (Fragment) OS=Mus musculus OX=10090 GN=Tuba4a PE=1 SV=1 0 155.236 42 17 139 3 477 52.9 5.19 6 12 14 17 7 31 31 70 5055875.875 5296820.813 31540253.19 2 4 4 cell organization and biogenesis catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" ENSMUSG00000026202.13 1 0 High A2A513 "Keratin, type I cytoskeletal 10 OS=Mus musculus OX=10090 GN=Krt10 PE=1 SV=1" 0 55.794 17 12 137 10 561 57 5.07 10 11 9 10 34 36 35 32 311125129.3 466503179.9 446559917.7 406629515 14 14 14 13 cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus protein binding;structural molecule activity Pf00038 16661 ENSMUSG00000019761.10 Krt10 11 Formation of the cornified envelope Staphylococcus aureus infection 0 High Q60936 "Atypical kinase COQ8A, mitochondrial OS=Mus musculus OX=10090 GN=Coq8a PE=1 SV=2" 0 198.061 40 23 137 23 645 71.7 6.54 5 9 12 23 7 17 20 93 7654665.396 31317572.65 38610802.32 496744461.9 16 20 21 28 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding Pf03109 67426 ENSMUSG00000026489.13 Adck3; Coq8a 1 0 High P10126 Elongation factor 1-alpha 1 OS=Mus musculus OX=10090 GN=Eef1a1 PE=1 SV=3 0 85.93 47 15 126 15 462 50.1 9.01 9 11 10 15 22 29 30 45 49044140.91 103418528.7 105913039.4 290183106.8 12 13 12 14 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf03143, Pf03144" 13627 ENSMUSG00000037742.14 Eef1a1; LOC101056619 9 Legionellosis; RNA transport 0 High Q61781 "Keratin, type I cytoskeletal 14 OS=Mus musculus OX=10090 GN=Krt14 PE=1 SV=2" 0 83.407 45 21 122 5 484 52.8 5.17 18 17 13 15 36 33 25 28 185748644 280976440.6 218669684.6 243677088.5 24 22 20 21 cell differentiation;cell organization and biogenesis;response to stimulus cytoplasm;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 16664 ENSMUSG00000045545.8 Krt14 11 Type I hemidesmosome assembly; Formation of the cornified envelope 19 High Q8BFR5 "Elongation factor Tu, mitochondrial OS=Mus musculus OX=10090 GN=Tufm PE=1 SV=1" 0 178.337 70 26 122 26 452 49.5 7.56 6 17 16 26 8 27 27 60 15985599.34 72827535.78 87816786.58 398865692 20 22 23 26 metabolic process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00009, Pf03143, Pf03144" 233870 ENSMUSG00000073838.10 Tufm 7 0 High Q6IFZ6 "Keratin, type II cytoskeletal 1b OS=Mus musculus OX=10090 GN=Krt77 PE=1 SV=1" 0 31.391 9 8 120 1 572 61.3 8.02 5 6 5 7 29 29 33 29 44971420 63950621.25 51522248 45878482.38 1 1 1 2 cytoskeleton protein binding;structural molecule activity "Pf00038, Pf09728, Pf13166" 406220 ENSMUSG00000067594.5 Krt77 15 Formation of the cornified envelope 0 High Q9WTX6 Cullin-1 OS=Mus musculus OX=10090 GN=Cul1 PE=1 SV=1 0 168.674 44 32 119 32 776 89.6 8 24 22 32 34 34 51 1041168.563 68806624.84 62484250.68 95721743.48 1 28 29 32 cell death;cell proliferation;metabolic process catalytic activity;protein binding "Pf00888, Pf10557" 26965 ENSMUSG00000029686.15 Cul1 6 NIK-->noncanonical NF-kB signaling; Degradation of beta-catenin by the destruction complex; Prolactin receptor signaling; SCF-beta-TrCP mediated degradation of Emi1; Regulation of RUNX2 expression and activity; SCF(Skp2)-mediated degradation of p27/p21; Neddylation; GLI3 is processed to GLI3R by the proteasome; Dectin-1 mediated noncanonical NF-kB signaling; Activation of NF-kappaB in B cells; Activated TLR4 signalling; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Regulation of PLK1 Activity at G2/M Transition; Downstream TCR signaling; Cyclin D associated events in G1; Interleukin-1 family signaling; Iron uptake and transport; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; MAP3K8 (TPL2)-dependent MAPK1/3 activation Herpes simplex infection; Wnt signaling pathway; Ubiquitin mediated proteolysis; Circadian rhythm; Oocyte meiosis; Cell cycle; TGF-beta signaling pathway; Hedgehog signaling pathway; Protein processing in endoplasmic reticulum 0 High Q9EQK5 Major vault protein OS=Mus musculus OX=10090 GN=Mvp PE=1 SV=4 0 113.503 39 28 118 28 861 95.9 5.59 23 20 19 18 34 28 28 28 57689424.75 73391988.81 56745800.56 48282055.22 25 25 24 24 Met-loss+Acetyl [N-Term] cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding "Pf01145, Pf01505, Pf11978" 78388 Mvp 7 0 High P60710 "Actin, cytoplasmic 1 OS=Mus musculus OX=10090 GN=Actb PE=1 SV=1" 0 125.682 69 17 116 1 375 41.7 5.48 8 10 13 16 15 23 30 48 36024956.62 79759457.38 98575311.34 259210513.9 16 19 19 21 Met-loss+Acetyl [N-Term] cell organization and biogenesis;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus DNA binding;nucleotide binding;protein binding Pf00022 11461 ENSMUSG00000029580.14 Actb 5 Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; UCH proteinases; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases activate IQGAPs; Formation of annular gap junctions; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling Oxytocin signaling pathway; Leukocyte transendothelial migration; Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Hippo signaling pathway; Platelet activation; Dilated cardiomyopathy; Adherens junction; Phagosome; Proteoglycans in cancer; Salmonella infection; Thyroid hormone signaling pathway; Rap1 signaling pathway; Influenza A; Viral myocarditis; Tight junction; Gastric acid secretion; Bacterial invasion of epithelial cells; Apoptosis 19 High P11031 Activated RNA polymerase II transcriptional coactivator p15 OS=Mus musculus OX=10090 GN=Sub1 PE=1 SV=3 0 47.835 57 11 116 11 127 14.4 9.6 9 9 10 10 31 24 32 29 138892145.7 110659162.5 128952637.4 117621013.2 12 12 13 13 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf02229 20024 ENSMUSG00000022205.15 Sub1 15 0 High Q99KI0 "Aconitate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Aco2 PE=1 SV=1" 0 130.777 40 26 115 26 780 85.4 7.93 19 18 12 20 32 27 21 35 79835274.72 86891074.81 71372156.22 113619806 23 24 22 23 metabolic process;response to stimulus mitochondrion catalytic activity;metal ion binding "Pf00330, Pf00694" 11429 ENSMUSG00000022477.12 Aco2 15 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High Q922U2 "Keratin, type II cytoskeletal 5 OS=Mus musculus OX=10090 GN=Krt5 PE=1 SV=1" 0 78.176 18 19 115 8 580 61.7 7.75 15 15 16 15 30 28 30 27 258756686.5 397070094.2 384717238.9 365805637.7 17 17 18 16 metabolic process cytoplasm;membrane;mitochondrion;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf03961, Pf04111, Pf05957" 110308 ENSMUSG00000061527.6 Krt5 15 Type I hemidesmosome assembly; Formation of the cornified envelope 7 High Q8BKI2 Trinucleotide repeat-containing gene 6B protein OS=Mus musculus OX=10090 GN=Tnrc6b PE=1 SV=2 0 137.396 28 31 113 31 1810 191.8 6.3 19 25 19 20 29 32 25 27 32487914.97 49930182.09 32316688 35958039.75 26 27 22 22 regulation of biological process cytoplasm RNA binding "Pf10427, Pf13893" 213988 ENSMUSG00000047888.9 Tnrc6b 15 Post-transcriptional silencing by small RNAs 0 High P63260 "Actin, cytoplasmic 2 OS=Mus musculus OX=10090 GN=Actg1 PE=1 SV=1" 0 122.743 69 17 113 1 375 41.8 5.48 8 9 13 16 15 21 31 46 477139.7188 816144.125 1607204.906 2742881.063 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane;nucleus nucleotide binding;protein binding;structural molecule activity Pf00022 11465 ENSMUSG00000062825.15 Actg1 11 Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate IQGAPs; Formation of annular gap junctions; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling Oxytocin signaling pathway; Leukocyte transendothelial migration; Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Hippo signaling pathway; Platelet activation; Dilated cardiomyopathy; Adherens junction; Phagosome; Proteoglycans in cancer; Salmonella infection; Thyroid hormone signaling pathway; Rap1 signaling pathway; Influenza A; Viral myocarditis; Tight junction; Bacterial invasion of epithelial cells; Apoptosis 0 High Q6IFX2 "Keratin, type I cytoskeletal 42 OS=Mus musculus OX=10090 GN=Krt42 PE=1 SV=1" 0 61.434 33 17 106 4 452 50.1 5.16 12 15 12 13 29 30 24 23 26717323.69 28595685.38 18357035.31 25488953.5 5 6 4 5 cytoplasm structural molecule activity "Pf00038, Pf04156, Pf08317, Pf13166, Pf13514" 68239 ENSMUSG00000053654.7 Krt42 11 2 High Q8R3N1 Nucleolar protein 14 OS=Mus musculus OX=10090 GN=Nop14 PE=1 SV=2 0 113.685 33 29 103 29 860 98.7 7.59 27 22 20 36 32 35 12762362.98 95813081.13 82731476.53 90632730.66 9 29 29 28 metabolic process membrane;nucleus protein binding;RNA binding Pf04147 75416 ENSMUSG00000036693.12 Nop14 5 Major pathway of rRNA processing in the nucleolus and cytosol 0 High Q9DCW4 Electron transfer flavoprotein subunit beta OS=Mus musculus OX=10090 GN=Etfb PE=1 SV=3 0 95.143 58 15 101 15 255 27.6 8.1 6 10 9 15 11 18 22 50 8331799.891 22212381 26176433.09 132882080.5 13 15 15 16 metabolic process;transport cytosol;mitochondrion;organelle lumen Pf01012 110826 ENSMUSG00000004610.4 Etfb 7 Protein methylation; Respiratory electron transport 0 High Q9QWL7 "Keratin, type I cytoskeletal 17 OS=Mus musculus OX=10090 GN=Krt17 PE=1 SV=3" 0 44.82 27 16 100 2 433 48.1 5.06 13 12 10 10 28 29 23 20 89073852.75 168397372.5 164210439.5 135323847.5 4 3 3 2 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding;receptor activity;signal transducer activity;structural molecule activity "Pf00038, Pf01576, Pf07888" 16667 ENSMUSG00000035557.9 Krt17 11 Formation of the cornified envelope 2 High P70404 "Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial OS=Mus musculus OX=10090 GN=Idh3g PE=1 SV=1" 0 172.894 50 14 99 14 393 42.8 9.01 5 9 10 14 7 16 20 56 16137338.63 43217259.25 48520300.84 411639859.1 10 9 12 19 metabolic process;regulation of biological process mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00180 15929 ENSMUSG00000002010.17 Idh3g X Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism 0 High P68134 "Actin, alpha skeletal muscle OS=Mus musculus OX=10090 GN=Acta1 PE=1 SV=1" 0 78.247 42 14 98 5 377 42 5.39 6 10 11 14 12 19 24 43 8128657.656 8112771.625 41252049.13 6 4 6 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton nucleotide binding;protein binding Pf00022 11459 ENSMUSG00000031972.5 Acta1 8 Striated Muscle Contraction 0 High Q922F4 Tubulin beta-6 chain OS=Mus musculus OX=10090 GN=Tubb6 PE=1 SV=1 0 109.447 64 21 95 11 447 50.1 4.89 3 6 8 21 3 10 13 69 531798.8438 2374458.039 3633414.852 27699518.72 2 4 6 8 cell organization and biogenesis cytoplasm;cytoskeleton;nucleus catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953, Pf10644" 67951 ENSMUSG00000001473.6 Tubb6 18 Intraflagellar transport; Hedgehog 'on' state; Hedgehog 'off' state Phagosome; Gap junction 0 High P62869 Elongin-B OS=Mus musculus OX=10090 GN=Elob PE=1 SV=1 0 57.61 86 9 95 9 118 13.2 5.01 9 9 9 8 19 27 26 23 49615856.2 86709285 79515839.81 61387779.44 9 11 10 11 Acetyl [N-Term] metabolic process;regulation of biological process nucleus protein binding Pf00240 67673 ENSMUSG00000055839.5 Tceb2; Elob 17 RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin mediated proteolysis; HIF-1 signaling pathway; Pathways in cancer; Renal cell carcinoma 0 High Q3U7K7 E3 ubiquitin-protein ligase TRIM21 OS=Mus musculus OX=10090 GN=Trim21 PE=1 SV=1 0 115.977 45 21 94 21 462 53.3 6.7 21 17 17 35 29 30 2242755.203 115208089.4 98391574.06 116114693.4 6 21 21 20 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227" 20821 ENSMUSG00000030966.13 Trim21 7 Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA Systemic lupus erythematosus 0 High Q99LC5 "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Etfa PE=1 SV=2" 0 140.589 68 17 92 17 333 35 8.38 6 12 12 17 6 17 20 49 12056339.55 42414734.3 52829771.51 346057659.1 13 17 18 20 metabolic process;transport mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00766, Pf01012" 110842 ENSMUSG00000032314.14 Etfa 9 Respiratory electron transport 0 High Q3TTY5 "Keratin, type II cytoskeletal 2 epidermal OS=Mus musculus OX=10090 GN=Krt2 PE=1 SV=1" 0 69.431 27 21 92 15 707 70.9 8.06 10 17 9 15 18 28 20 26 346491518.2 781558687 456796193.6 493434726.5 19 21 20 21 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process cytoskeleton;membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf13166" 16681 ENSMUSG00000064201.8 Krt2 15 Formation of the cornified envelope 6 High Q9WUM5 "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Suclg1 PE=1 SV=4" 0 96.414 37 14 91 14 346 36.1 9.39 6 10 9 13 8 17 17 49 17699880.41 78183360.11 72839265.64 393839124.3 9 10 10 13 metabolic process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00549, Pf02629, Pf13607" 56451 ENSMUSG00000052738.14 Suclg1 6 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Propanoate metabolism; Carbon metabolism 0 High Q9Z1A1 TFG protein OS=Mus musculus OX=10090 GN=Tfg PE=1 SV=1 0 66.587 44 12 89 12 397 43 5.1 9 9 9 9 22 25 26 16 43858744.5 61201868.28 70973174.44 35824791.89 12 14 13 13 Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus;transport membrane protein binding;signal transducer activity "Pf00564, Pf08232" 21787 ENSMUSG00000022757.18 Tfg 16 COPII (Coat Protein 2) Mediated Vesicle Transport 0 High Q8K2B3 "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Mus musculus OX=10090 GN=Sdha PE=1 SV=1" 0 102.545 38 19 89 19 664 72.5 7.37 15 14 12 15 20 18 20 31 26046574.8 29997516.99 26711627.66 53345332.91 19 19 19 18 metabolic process;transport membrane;mitochondrion catalytic activity;nucleotide binding "Pf00890, Pf02910" 66945 ENSMUSG00000021577.13 Sdha 13 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Carbon metabolism 0 High P08121 Collagen alpha-1(III) chain OS=Mus musculus OX=10090 GN=Col3a1 PE=1 SV=4 0 118.394 27 25 89 25 1464 138.9 6.52 7 24 16 8 10 41 29 9 17216227.94 59450663.47 73516935.81 25492584.58 16 23 23 13 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus extracellular metal ion binding;protein binding;structural molecule activity "Pf00093, Pf01391, Pf01410, Pf14828" 12825 ENSMUSG00000026043.18 Col3a1 1 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; MET activates PTK2 signaling; NCAM1 interactions; Collagen degradation; Non-integrin membrane-ECM interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures AGE-RAGE signaling pathway in diabetic complications; Protein digestion and absorption; Platelet activation; Amoebiasis 0 High Q8BTI8 Serine/arginine repetitive matrix protein 2 OS=Mus musculus OX=10090 GN=Srrm2 PE=1 SV=3 0 75.888 13 22 88 22 2703 294.7 12.03 17 19 17 10 24 26 25 13 31693830.95 33289136.46 37352472.94 25085885.28 20 22 20 15 metabolic process nucleus;spliceosomal complex protein binding;RNA binding 75956 ENSMUSG00000039218.16 Srrm2 17 mRNA Splicing - Major Pathway 0 High P62806 Histone H4 OS=Mus musculus OX=10090 GN=H4c1 PE=1 SV=2 0 49.894 57 10 88 10 103 11.4 11.36 7 9 10 6 19 30 29 10 40070249.23 198537935.4 175724532.7 43576129.88 11 11 11 8 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00125, Pf02969, Pf15630" 320332; 326619; 319160; 319155; 319158; 319161; 69386; 319157; 319159; 326620; 100041230; 319156; 97122; 102641229 ENSMUSG00000096010.2; ENSMUSG00000091405.2; ENSMUSG00000060981.6; ENSMUSG00000069274.3; ENSMUSG00000061482.6; ENSMUSG00000067455.5; ENSMUSG00000064288.4; ENSMUSG00000060678.4; ENSMUSG00000069306.5; ENSMUSG00000069305.3; ENSMUSG00000069266.5; ENSMUSG00000060093.6; ENSMUSG00000060639.5 Hist4h4; Hist1h4a; Hist1h4k; Hist1h4c; Hist1h4i; Hist1h4n; Hist1h4h; Hist1h4f; Hist1h4j; Hist1h4b; Hist1h4m; Hist1h4d; Hist2h4; LOC100862646; LOC102641229 6; 13; 3 Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HATs acetylate histones; Meiotic Recombination; HDMs demethylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; PRC2 methylates histones and DNA; SUMOylation of chromatin organization proteins; Nonhomologous End-Joining (NHEJ); RMTs methylate histone arginines; NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); DNA Damage/Telomere Stress Induced Senescence; SIRT1 negatively regulates rRNA expression; Condensation of Prophase Chromosomes; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; NoRC negatively regulates rRNA expression; Meiotic Synapsis; G2/M DNA damage checkpoint; PKMTs methylate histone lysines; Mus musculus biological processes; RNA Polymerase I Chain Elongation Alcoholism; Systemic lupus erythematosus; Viral carcinogenesis 0 High P42125 "Enoyl-CoA delta isomerase 1, mitochondrial OS=Mus musculus OX=10090 GN=Eci1 PE=1 SV=2" 0 90.627 60 14 87 14 289 32.2 8.98 5 8 7 14 9 14 15 49 16143828.54 41475801.59 45609870.44 328084197.9 11 13 13 16 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding Pf00378 13177 ENSMUSG00000024132.5 Eci1 17 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Fatty acid degradation 0 High P02088 Hemoglobin subunit beta-1 OS=Mus musculus OX=10090 GN=Hbb-b1 PE=1 SV=2 0 101.377 96 14 87 2 147 15.8 7.65 3 10 14 3 3 21 58 5 4421052.84 75067242.9 426401029.1 21995745 6 14 17 8 Met-loss [N-Term] regulation of biological process;transport antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 15129; 100503605; 101488143 Hbb-b1; Beta-s; Hbb-bs; Hbb-bt 7 African trypanosomiasis; Malaria 15 High B2RY56 RNA-binding protein 25 OS=Mus musculus OX=10090 GN=Rbm25 PE=1 SV=2 0 98.022 30 20 87 20 838 99.5 6.32 14 16 11 13 21 24 21 21 41085469.53 73186242.38 65704643.94 53441384.44 20 18 18 17 cell death;metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex RNA binding "Pf00076, Pf01480, Pf14259" 67039 ENSMUSG00000010608.15 Rbm25 12 Spliceosome 0 High P50446 "Keratin, type II cytoskeletal 6A OS=Mus musculus OX=10090 GN=Krt6a PE=1 SV=3" 0 70.143 23 17 84 4 553 59.3 7.94 14 11 12 14 23 21 16 24 27618331.53 13117649.38 8520319.125 20508325.66 8 8 5 7 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf05957, Pf12128, Pf13166" 16687 ENSMUSG00000058354.6 Krt6a 15 Formation of the cornified envelope 4 High Q9Z1R2 Large proline-rich protein BAG6 OS=Mus musculus OX=10090 GN=Bag6 PE=1 SV=1 0 119.955 25 19 84 19 1154 121 5.71 12 13 17 26 25 33 111546.2734 46503859.94 39561017.13 54416609.31 1 17 16 18 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;membrane;nucleus protein binding "Pf00240, Pf11976, Pf12057" 224727 ENSMUSG00000024392.17 Bag6 17 0 High Q61414 "Keratin, type I cytoskeletal 15 OS=Mus musculus OX=10090 GN=Krt15 PE=1 SV=2" 0 25.632 14 10 83 1 452 49.1 4.86 8 10 9 9 21 23 19 20 4507288.25 6419198.5 5823509.625 5280250.625 2 1 2 2 nucleus protein binding;structural molecule activity "Pf00038, Pf12128, Pf13514" 16665 Krt15 11 1 High Q8C6G1 Cilia- and flagella-associated protein 410 OS=Mus musculus OX=10090 GN=Cfap410 PE=1 SV=1 0 100.252 65 14 82 14 249 28.2 6.93 13 12 14 25 26 31 1235891.516 100703399.3 102568243.7 114800128.7 2 14 15 15 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion protein binding "Pf12799, Pf13855, Pf14580" 67884 ENSMUSG00000020284.16 1810043G02Rik 10 0 High E9Q4Z2 Acetyl-CoA carboxylase 2 OS=Mus musculus OX=10090 GN=Acacb PE=1 SV=1 0 137.924 18 36 80 27 2448 275.6 6.32 1 10 8 35 1 17 13 49 1644288.109 4899059.078 5609606.422 41182603.94 8 11 13 24 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf13535, Pf15632" 100705 ENSMUSG00000042010.16 Acacb 5 ChREBP activates metabolic gene expression; Biotin transport and metabolism; Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism; Insulin signaling pathway; Metabolic pathways; Insulin resistance; Propanoate metabolism; Adipocytokine signaling pathway; AMPK signaling pathway; Fatty acid biosynthesis; Glucagon signaling pathway 0 High G3UXT7 RNA-binding protein FUS (Fragment) OS=Mus musculus OX=10090 GN=Fus PE=1 SV=1 0 73.676 58 10 80 10 130 14 8.97 8 10 8 7 22 23 20 15 58020970.63 67676390.75 58891570 38064003.13 11 11 11 9 regulation of biological process cytoplasm;nucleus metal ion binding;RNA binding "Pf00076, Pf00641, Pf13893, Pf14259" ENSMUSG00000030795.18 7 0 High H9KV15 Protein SON OS=Mus musculus OX=10090 GN=Son PE=1 SV=1 0 92.855 15 22 79 22 2343 253.9 5.4 15 22 12 24 38 17 1378900.125 42250870.97 44538769.03 19563899.03 6 22 21 16 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding 20658 ENSMUSG00000022961.17 Son 16 0 High P59913 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Pcmtd1 PE=1 SV=1 0 39.626 37 14 78 14 357 40.7 5.66 11 10 10 9 19 22 22 15 46204904.92 89915261.88 78929603.41 56697159.16 13 14 14 11 metabolic process cytoplasm;membrane catalytic activity "Pf01135, Pf12847, Pf13847" 319263 ENSMUSG00000051285.17 Pcmtd1 1 0 High Q8K010 5-oxoprolinase OS=Mus musculus OX=10090 GN=Oplah PE=1 SV=1 0 154.956 32 33 78 33 1288 137.5 6.28 2 19 12 30 2 24 12 40 2666703.898 29173814.68 20786878.84 50656467.84 12 29 27 29 metabolic process cytosol catalytic activity;nucleotide binding "Pf01968, Pf02538, Pf05378" 75475 ENSMUSG00000022562.14 Oplah 15 Glutathione synthesis and recycling Glutathione metabolism 0 High Q91VB8 Alpha globin 1 OS=Mus musculus OX=10090 GN=Hba-a1 PE=1 SV=1 0 59.683 64 8 78 8 142 15.1 8.22 3 5 8 5 8 17 40 13 8150415.445 60636309.19 243133087.8 24099303.14 5 8 10 8 response to stimulus;transport membrane antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 15122; 110257 ENSMUSG00000069919.7; ENSMUSG00000069917.7 Hba-a1; Hba-a2 11 Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Scavenging of heme from plasma African trypanosomiasis; Malaria 0 High Q9Z1R9 "Protease, serine 1 (trypsin 1) OS=Mus musculus OX=10090 GN=Prss1 PE=1 SV=1" 0 35.283 12 2 78 1 246 26.1 4.94 1 1 2 2 20 18 21 19 469741484.9 502373060 539579597.6 496805694.8 2 2 2 2 metabolic process catalytic activity Pf00089 114228 ENSMUSG00000062751.5 Prss1 6 "Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation; Collagen degradation; Antimicrobial peptides; Activation of Matrix Metalloproteinases" 0 High A8DUK4 Beta-globin OS=Mus musculus OX=10090 GN=Hbb-bs PE=1 SV=1 0 93.766 95 13 76 3 147 15.7 7.69 4 9 13 4 4 15 51 6 3925503.281 6974663.188 21529177.19 11345367.88 4 3 4 3 Met-loss [N-Term] regulation of biological process;transport antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity Pf00042 100503605; 101488143; 15129 ENSMUSG00000073940.3; ENSMUSG00000052305.6 Beta-s; Hbb-bs; Hbb-bt; Hbb-b1 7 Erythrocytes take up carbon dioxide and release oxygen; Neutrophil degranulation; Factors involved in megakaryocyte development and platelet production; Erythrocytes take up oxygen and release carbon dioxide; Scavenging of heme from plasma African trypanosomiasis; Malaria 0 High P51881 ADP/ATP translocase 2 OS=Mus musculus OX=10090 GN=Slc25a5 PE=1 SV=3 0 58.167 51 16 75 8 298 32.9 9.73 7 8 8 16 10 13 15 37 14242379.71 30337448.53 35658781.31 207156116 14 12 13 13 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;RNA binding;transporter activity Pf00153 11740 ENSMUSG00000016319.3 Slc25a5 X Regulation of insulin secretion HTLV-I infection; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway 7 High Q9JJZ2 Tubulin alpha-8 chain OS=Mus musculus OX=10090 GN=Tuba8 PE=1 SV=1 0 103.465 32 12 73 1 449 50 5.1 4 7 8 12 5 17 16 35 cell organization and biogenesis cytoplasm;cytoskeleton catalytic activity;nucleotide binding;structural molecule activity "Pf00091, Pf03953" 53857 ENSMUSG00000030137.8 Tuba8 6 Phagosome; Gap junction; Apoptosis 0 High Q8VEK3 Heterogeneous nuclear ribonucleoprotein U OS=Mus musculus OX=10090 GN=Hnrnpu PE=1 SV=1 0 84.797 24 18 73 18 800 87.9 6.24 4 15 13 14 5 24 19 25 8014552.188 36521857.38 40031469.5 44335337.25 16 18 19 18 Met-loss+Acetyl [N-Term] cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex DNA binding;nucleotide binding;protein binding;RNA binding "Pf00622, Pf13671" 51810 ENSMUSG00000039630.10; ENSMUSG00000111145.1 Hnrnpu 1; CHR_MG4281_PATCH mRNA Splicing - Major Pathway Spliceosome 0 High Q8CJG0 Protein argonaute-2 OS=Mus musculus OX=10090 GN=Ago2 PE=1 SV=3 0 79.982 30 22 71 18 860 97.2 9.19 13 14 18 14 14 17 22 18 19355717.09 30188924.09 28581855.11 29944916.77 17 19 18 18 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 239528 ENSMUSG00000036698.10 Ago2; Eif2c2 15 MicroRNA (miRNA) biogenesis; Transcriptional regulation by small RNAs; Post-transcriptional silencing by small RNAs; Small interfering RNA (siRNA) biogenesis 3 High E0CYV0 Protein-L-isoaspartate O-methyltransferase OS=Mus musculus OX=10090 GN=Pcmt1 PE=1 SV=1 0 75.826 46 11 71 11 286 30.4 7.24 8 11 11 10 9 23 22 17 16776969.95 62250897.69 47663380.31 41478607.06 12 12 12 13 metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity "Pf01135, Pf01209, Pf05175, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847" 18537 ENSMUSG00000019795.17 Pcmt1 10 Protein repair 0 High Q8CH09 SURP and G-patch domain-containing protein 2 OS=Mus musculus OX=10090 GN=Sugp2 PE=1 SV=2 0 88.024 27 18 71 18 1067 118 8.31 16 15 15 24 23 24 27985787.88 27511525 23697624.91 17 17 15 metabolic process nucleus RNA binding "Pf01585, Pf01805" 234373 ENSMUSG00000036054.15 Sugp2 8 0 High Q9D8E6 60S ribosomal protein L4 OS=Mus musculus OX=10090 GN=Rpl4 PE=1 SV=3 0 52.72 40 14 70 14 419 47.1 11 6 13 13 12 7 19 22 22 10947531.59 56625492.85 47054045.08 45481641.84 13 16 16 16 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00573, Pf14374" 67891 ENSMUSG00000032399.8 Rpl4 9 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q64475 Histone H2B type 1-B OS=Mus musculus OX=10090 GN=H2bc3 PE=1 SV=3 0 30.255 53 8 69 8 126 13.9 10.32 5 6 8 7 11 21 25 12 93337072.73 363952967.8 417249341 102697285.6 9 9 9 8 cell organization and biogenesis chromosome;cytosol;nucleus DNA binding;protein binding "Pf00125, Pf00808" 319178 ENSMUSG00000075031.3 Hist1h2bb 13 HATs acetylate histones; E3 ubiquitin ligases ubiquitinate target proteins; Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus; Viral carcinogenesis 0 High Q8BHD8 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pcmtd2 PE=2 SV=1 0 53.659 40 13 69 13 359 40.7 6.46 7 12 12 11 10 19 23 17 14809033.38 39120155.5 35693474.56 31942302.88 12 13 13 11 Met-loss [N-Term] metabolic process cytoplasm catalytic activity "Pf01135, Pf12847, Pf13847" 245867 ENSMUSG00000027589.14 Pcmtd2 2 0 High P01027 Complement C3 OS=Mus musculus OX=10090 GN=C3 PE=1 SV=3 0 38.115 8 15 68 15 1663 186.4 6.73 13 12 11 28 23 17 418620.9141 98951224.44 84786989.5 60164764.81 3 12 13 12 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974" 12266 ENSMUSG00000024164.15 C3 17 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Regulation of Complement cascade; Peptide ligand-binding receptors; G alpha (i) signalling events; Activation of C3 and C5; Post-translational protein phosphorylation; Alternative complement activation; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Herpes simplex infection; Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Tuberculosis; Phagosome; Complement and coagulation cascades; Pertussis; Legionellosis; Systemic lupus erythematosus; Leishmaniasis; Viral carcinogenesis 0 High Q8C605 ATP-dependent 6-phosphofructokinase OS=Mus musculus OX=10090 GN=Pfkp PE=1 SV=1 0 156.939 34 23 68 20 784 85.5 6.89 1 1 3 23 2 3 5 58 4099106.844 4959490.922 6945123.406 44275157.06 5 7 11 15 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 56421 ENSMUSG00000021196.13 Pfkp 13 RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Thyroid hormone signaling pathway; Pentose phosphate pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer 0 High P56480 "ATP synthase subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1b PE=1 SV=2" 0 136.389 64 23 67 23 529 56.3 5.34 2 7 10 21 2 7 12 46 7968187.688 23327735.26 24852883.32 119325857.7 6 18 16 22 cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;transport cell surface;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity;transporter activity "Pf00006, Pf00306, Pf02874" 11947 ENSMUSG00000025393.12 Atp5b 10 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High H3BJU7 Rho guanine nucleotide exchange factor 2 OS=Mus musculus OX=10090 GN=Arhgef2 PE=1 SV=1 0 105.084 31 22 67 22 956 108.5 6.87 15 11 19 23 16 28 292707.5625 29439764.31 21193571.39 43363773 2 18 17 21 regulation of biological process;response to stimulus metal ion binding "Pf00130, Pf00169, Pf00621, Pf07649" ENSMUSG00000028059.15 3 0 High P62702 "40S ribosomal protein S4, X isoform OS=Mus musculus OX=10090 GN=Rps4x PE=1 SV=2" 0 57.957 56 17 66 17 263 29.6 10.15 8 15 13 9 11 27 17 11 20514004.03 40837675.69 40881723.84 33952587.06 18 16 17 16 development;metabolic process;regulation of biological process cytoplasm;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00900, Pf08071" 20102 ENSMUSG00000031320.9 Rps4x X "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High S4R2L4 Arginine/serine-rich coiled-coil protein 2 OS=Mus musculus OX=10090 GN=Rsrc2 PE=1 SV=1 0 48.743 24 9 65 9 434 50.6 11.36 8 8 8 9 15 19 15 16 27665997.08 47869295.8 23368529.17 34598995.05 10 11 11 11 Met-loss+Acetyl [N-Term] RNA binding Pf15477 208606 ENSMUSG00000029422.14 Rsrc2 5 0 High Q8K310 Matrin-3 OS=Mus musculus OX=10090 GN=Matr3 PE=1 SV=1 0 76.956 30 22 64 22 846 94.6 6.25 1 19 15 11 1 25 24 14 2682035.703 33710146.88 36267258.75 31019645.81 13 20 22 19 defense response;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 17184 ENSMUSG00000037236.14 Matr3 18 0 High P83940 Elongin-C OS=Mus musculus OX=10090 GN=Eloc PE=1 SV=1 0 65.306 66 7 63 7 112 12.5 4.78 7 7 7 6 14 19 17 13 30440008.38 53212370 54879161.63 51458486.75 9 8 9 8 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf03931 67923; 102642819 ENSMUSG00000079658.9 Tceb1; Eloc; LOC101056616; LOC102642819 1; 2 RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Interleukin-7 signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin mediated proteolysis; HIF-1 signaling pathway; Pathways in cancer; Renal cell carcinoma 0 High P19001 "Keratin, type I cytoskeletal 19 OS=Mus musculus OX=10090 GN=Krt19 PE=1 SV=1" 0 17.928 11 7 63 1 403 44.5 5.39 6 7 6 6 16 19 14 14 423217.8125 206237.2656 193919.7188 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoskeleton;membrane protein binding;structural molecule activity Pf00038 16669 ENSMUSG00000020911.14 Krt19 11 Formation of the cornified envelope 0 High Q9D5V5 Cullin-5 OS=Mus musculus OX=10090 GN=Cul5 PE=1 SV=3 0 53.681 23 17 63 17 780 90.9 7.81 11 15 11 13 14 18 15 16 29863368.92 48864544.97 36352763.39 33519400.47 16 17 16 17 cellular component movement;cellular homeostasis;metabolic process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;protein binding "Pf00888, Pf10557" 75717 Cul5 9 Ubiquitin mediated proteolysis 0 High P63038 "60 kDa heat shock protein, mitochondrial OS=Mus musculus OX=10090 GN=Hspd1 PE=1 SV=1" 0 112.109 39 18 62 18 573 60.9 6.18 5 11 8 17 6 13 13 30 7628744.992 21817360.63 16723393.02 64528575.47 11 14 12 18 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding Pf00118 15510 ENSMUSG00000025980.14 Hspd1 1 RNA degradation; Tuberculosis; Legionellosis; Type I diabetes mellitus 0 High P02089 Hemoglobin subunit beta-2 OS=Mus musculus OX=10090 GN=Hbb-b2 PE=1 SV=2 0 62.679 91 13 61 5 147 15.9 8.05 2 6 13 3 2 11 43 5 10153375.5 54032239.63 123041.7734 2 4 1 Met-loss [N-Term] regulation of biological process;response to stimulus;transport membrane metal ion binding;transporter activity Pf00042 15130 Hbb-b2 7 African trypanosomiasis; Malaria 0 High E0CX53 TBC1 domain family member 4 OS=Mus musculus OX=10090 GN=Tbc1d4 PE=1 SV=1 0 120.371 28 25 61 25 1306 147.2 7.39 17 15 20 21 18 22 27544747.66 21527812.41 24154626.34 18 17 15 Acetyl [N-Term] regulation of biological process;response to stimulus;transport cytoplasm;cytosol enzyme regulator activity;protein binding "Pf00566, Pf00640, Pf11830" 210789 ENSMUSG00000033083.16 Tbc1d4 14 Translocation of GLUT4 to the plasma membrane 0 High P09103 Protein disulfide-isomerase OS=Mus musculus OX=10090 GN=P4hb PE=1 SV=2 0 67.09 43 19 60 19 509 57 4.88 4 13 7 17 5 18 10 27 6220821.5 25482508.03 20422843.22 55982073.19 11 17 17 18 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding;protein binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13899, Pf13905" 18453 ENSMUSG00000025130.11 P4hb 11 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Detoxification of Reactive Oxygen Species; Chylomicron assembly; Interleukin-12 family signaling; VLDL assembly; Hedgehog ligand biogenesis; Collagen biosynthesis and modifying enzymes Protein processing in endoplasmic reticulum 0 High E9Q1Z0 Keratin 90 OS=Mus musculus OX=10090 GN=Krt90 PE=1 SV=1 0 32.065 14 10 60 2 538 58.2 8.25 9 6 6 9 15 14 14 17 104271591.3 137149165.9 133207541.4 86358443.31 3 3 3 2 cell organization and biogenesis;metabolic process catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf06810, Pf09728, Pf12128, Pf13166, Pf13514" 239673 ENSMUSG00000048699.4 4732456N10Rik; Krt90 15 1 High P45952 "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadm PE=1 SV=1" 0 96.546 51 19 58 19 421 46.5 8.37 3 4 7 19 4 7 10 37 8285331.145 19220193.21 22151710.5 146123913.2 11 13 13 18 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00441, Pf02770, Pf02771, Pf08028" 11364 ENSMUSG00000062908.12 Acadm 3 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA "PPAR signaling pathway; Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; beta-Alanine metabolism; Propanoate metabolism; Carbon metabolism" 0 High P35700 Peroxiredoxin-1 OS=Mus musculus OX=10090 GN=Prdx1 PE=1 SV=1 0 28.515 50 10 58 9 199 22.2 8.12 9 7 7 9 16 14 14 14 14025088.25 27260466.13 22766135.56 38738902.94 8 8 8 8 cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00578, Pf08534, Pf10417" 18477 ENSMUSG00000028691.12 Prdx1 4 Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes Peroxisome 1 High P47911 60S ribosomal protein L6 OS=Mus musculus OX=10090 GN=Rpl6 PE=1 SV=3 0 58.555 43 12 58 12 296 33.5 10.7 4 12 10 9 4 21 18 15 11647892.27 50482404 42460124.84 56236675.08 12 12 12 12 cell organization and biogenesis;metabolic process cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf01159, Pf03868" 19988 ENSMUSG00000029614.13 Rpl6 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9Z2K1 "Keratin, type I cytoskeletal 16 OS=Mus musculus OX=10090 GN=Krt16 PE=1 SV=3" 0 41.385 22 11 58 4 469 51.6 5.2 10 8 5 7 20 12 10 16 22397955.91 6398729.875 6426018.031 15052764.75 6 4 3 5 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus cytoskeleton;nucleus protein binding;structural molecule activity "Pf00038, Pf13514" 16666 ENSMUSG00000053797.10 Krt16 11 Formation of the cornified envelope 0 High Q9D0E1 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus OX=10090 GN=Hnrnpm PE=1 SV=3 0 80.449 33 18 58 18 729 77.6 8.63 3 15 11 14 3 22 16 17 6423742.539 33071078.89 27032867.84 28950660.5 12 19 19 17 metabolic process;regulation of biological process cell surface;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf11532, Pf11608, Pf13893, Pf14259" 76936 ENSMUSG00000059208.14 Hnrnpm 17 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High Q9QZN4 F-box only protein 6 OS=Mus musculus OX=10090 GN=Fbxo6 PE=1 SV=1 0 54.302 48 11 57 11 295 34.5 8.18 8 6 11 17 15 25 83103.6875 16723160.38 21306095.25 41900618.06 1 9 10 10 metabolic process;response to stimulus cytoplasm catalytic activity;protein binding "Pf00646, Pf04300, Pf12937" 50762 ENSMUSG00000055401.14 Fbxo6 4 Neddylation; Antigen processing: Ubiquitination & Proteasome degradation Protein processing in endoplasmic reticulum 0 High Q8C2Q8 ATP synthase subunit gamma OS=Mus musculus OX=10090 GN=Atp5c1 PE=1 SV=1 0 53.479 45 12 57 12 274 30.2 8.84 8 9 4 12 9 11 7 30 9490526.984 16868017.28 19691858.81 121822757.2 10 11 11 13 metabolic process;transport membrane;mitochondrion catalytic activity;RNA binding;transporter activity Pf00231 11949 ENSMUSG00000025781.14 Atp5c1 2 0 High E9PUU4 Gem-associated protein 5 OS=Mus musculus OX=10090 GN=Gemin5 PE=1 SV=1 0 109.619 22 25 57 1 1503 166.6 6.74 12 9 25 14 10 33 843382.8125 659156.375 871434.5625 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf00400 216766 ENSMUSG00000037275.14 Gemin5 11 0 High A2AGH8 Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 0 107.529 17 24 56 24 2157 240.7 7.17 5 16 8 20 5 19 9 23 4018498.438 14084087.56 10958786.98 16406117.22 9 16 15 18 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;protein binding;receptor activity "Pf09497, Pf09606, Pf12144, Pf12145" 59024 ENSMUSG00000079487.11 Med12 X 0 High P11499 Heat shock protein HSP 90-beta OS=Mus musculus OX=10090 GN=Hsp90ab1 PE=1 SV=3 0 91.606 24 16 56 13 724 83.2 5.03 1 10 5 15 1 12 6 37 1241138.742 10194980.81 7168078.469 30042052.31 7 13 13 13 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 15516 ENSMUSG00000023944.14 Hsp90ab1 17 The role of GTSE1 in G2/M progression after G2 checkpoint; HSF1 activation; Attenuation phase; Neutrophil degranulation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of actin dynamics for phagocytic cup formation; Aryl hydrocarbon receptor signalling; Sema3A PAK dependent Axon repulsion Progesterone-mediated oocyte maturation; NOD-like receptor signaling pathway; Pathways in cancer; Antigen processing and presentation; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Prostate cancer 0 High Q6GSS7 Histone H2A type 2-A OS=Mus musculus OX=10090 GN=Hist2h2aa1 PE=1 SV=3 0 29.091 41 7 55 3 130 14.1 10.9 5 5 7 4 10 17 19 9 72108105.8 270653129.4 251587114.1 56515934.58 6 7 8 5 cell organization and biogenesis;regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 319192; 15267 ENSMUSG00000063954.7; ENSMUSG00000064220.6 Hist2h2aa2; Hist2h2aa1 3 RMTs methylate histone arginines; Meiotic Recombination; Mus musculus biological processes; Ub-specific processing proteases; NoRC negatively regulates rRNA expression; UCH proteinases; Metalloprotease DUBs; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus 4 High P12970 60S ribosomal protein L7a OS=Mus musculus OX=10090 GN=Rpl7a PE=1 SV=2 0 61.369 45 16 55 16 266 30 10.56 3 12 11 14 4 18 14 19 10716918.94 56414823.69 45251355.25 60788521.31 12 17 17 17 metabolic process cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding Pf01248 27176 ENSMUSG00000062647.16 Rpl7a 2 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q60715 Prolyl 4-hydroxylase subunit alpha-1 OS=Mus musculus OX=10090 GN=P4ha1 PE=1 SV=2 0 122.448 49 23 55 6 534 60.9 5.9 2 5 4 23 2 6 4 43 2676583.719 10407820.44 5395678.547 140334149.6 12 15 12 22 cell organization and biogenesis;metabolic process endoplasmic reticulum;membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336" 18451 ENSMUSG00000019916.14 P4ha1 10 Collagen biosynthesis and modifying enzymes Arginine and proline metabolism; Metabolic pathways 16 High A2AFQ9 Gem-associated protein 5 OS=Mus musculus OX=10090 GN=Gemin5 PE=1 SV=1 0 105.972 22 25 55 1 1501 166.4 6.71 12 8 24 14 9 32 3482445.07 22957239.14 15937685.17 39550864.13 5 19 17 20 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding Pf00400 216766 ENSMUSG00000037275.14 Gemin5 11 20 High P21981 Protein-glutamine gamma-glutamyltransferase 2 OS=Mus musculus OX=10090 GN=Tgm2 PE=1 SV=4 0 60.344 25 15 55 15 686 77 5.1 7 12 14 7 8 17 20 10 9035792.781 27465988.53 33182832.16 12014166.09 13 13 12 11 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00868, Pf00927, Pf01841" 21817 ENSMUSG00000037820.15 Tgm2 2 Huntington's disease 0 High Q99KQ4 Nicotinamide phosphoribosyltransferase OS=Mus musculus OX=10090 GN=Nampt PE=1 SV=1 0 95.187 61 23 55 23 491 55.4 7.15 7 8 22 8 11 36 2788540.727 16972234.85 19852807.76 90134657.38 9 16 18 21 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;nucleus catalytic activity;protein binding Pf04095 59027 ENSMUSG00000020572.8 Nampt 12 "Circadian Clock; Mus musculus biological processes; Nicotinamide salvaging; Bmal1:Clock,Npas2 activates circadian gene expression" NOD-like receptor signaling pathway; Metabolic pathways; Nicotinate and nicotinamide metabolism 0 High Q8BGZ7 "Keratin, type II cytoskeletal 75 OS=Mus musculus OX=10090 GN=Krt75 PE=1 SV=1" 0 35.574 14 11 55 1 551 59.7 8.31 9 8 8 10 14 15 11 15 3915788.375 6354964.875 5316860 5345483.25 2 2 2 2 cell differentiation;metabolic process;transport catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00012, Pf00038, Pf01496, Pf01576, Pf04111, Pf04156, Pf09728, Pf13166" 109052 ENSMUSG00000022986.5 Krt75 15 Formation of the cornified envelope 0 High Q8CGP7 Histone H2A type 1-K OS=Mus musculus OX=10090 GN=H2ac15 PE=1 SV=3 0 26.661 41 6 54 2 130 14.1 11.05 4 6 6 4 8 19 18 9 1133453.672 4814058.375 6720460.25 634695.0703 2 2 2 2 regulation of biological process chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 319169 ENSMUSG00000063021.3 Hist1h2ak 13 Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus 0 High P47857 "ATP-dependent 6-phosphofructokinase, muscle type OS=Mus musculus OX=10090 GN=Pfkm PE=1 SV=3" 0 115.119 40 20 53 16 780 85.2 8 3 4 20 3 5 45 1487618.063 3542740.75 4221817.984 40706026.75 4 8 8 15 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00365 18642 ENSMUSG00000033065.13 Pfkm 15 Glycolysis RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Pentose phosphate pathway; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer 0 High P48962 ADP/ATP translocase 1 OS=Mus musculus OX=10090 GN=Slc25a4 PE=1 SV=4 0 49.241 55 16 53 8 298 32.9 9.72 4 4 5 16 6 7 10 30 1092286.734 2244416.781 2808830.813 15064211.31 3 4 5 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport membrane;mitochondrion;nucleus protein binding;transporter activity Pf00153 11739 ENSMUSG00000031633.4 Slc25a4 8 Regulation of insulin secretion HTLV-I infection; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway 0 High Q9JHU4 Cytoplasmic dynein 1 heavy chain 1 OS=Mus musculus OX=10090 GN=Dync1h1 PE=1 SV=2 0 127.792 10 37 52 37 4644 531.7 6.42 2 4 3 37 2 4 4 42 7756039.586 15636555.25 18084605.23 52762240.66 11 20 22 34 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;membrane catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00769, Pf03028, Pf03915, Pf04156, Pf07246, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13173, Pf13207, Pf13401" 13424 ENSMUSG00000018707.13 Dync1h1 12 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR); Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPI-independent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; RHO GTPases Activate Formins; MHC class II antigen presentation Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High Q9R1C7 Pre-mRNA-processing factor 40 homolog A OS=Mus musculus OX=10090 GN=Prpf40a PE=1 SV=1 0 53.864 19 17 52 17 953 108.4 7.69 6 13 12 8 11 15 15 11 29020100.2 59655705.3 49536906.68 49997550.02 12 16 16 16 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00397, Pf01846" 56194 ENSMUSG00000061136.14 Prpf40a 2 mRNA Splicing - Major Pathway Spliceosome 0 High E9Q718 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Mus musculus OX=10090 GN=Plod2 PE=1 SV=1" 0 99.317 36 23 52 23 758 86.8 6.89 3 3 23 5 5 42 969569.4258 7822149.57 7450762.656 119401692.3 8 11 12 22 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf03171 26432 ENSMUSG00000032374.14 Plod2 9 0 High Q9DB15 "39S ribosomal protein L12, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl12 PE=1 SV=2" 0 59.091 60 10 52 10 201 21.7 9.29 5 6 10 11 12 29 114565475.3 141391289.1 157290470 385534663.5 2 8 9 10 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;ribosome structural molecule activity Pf00542 56282 ENSMUSG00000039640.7 Mrpl12 11 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High P43277 Histone H1.3 OS=Mus musculus OX=10090 GN=H1-3 PE=1 SV=2 0 30.023 35 9 50 1 221 22.1 11.03 7 8 8 6 10 17 17 6 1584310 14328332 14560903.5 2038070.625 1 2 2 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 14957 ENSMUSG00000052565.6 Hist1h1d 13 1 High P11152 Lipoprotein lipase OS=Mus musculus OX=10090 GN=Lpl PE=1 SV=3 0 82.52 37 15 50 15 474 53.1 7.87 2 6 7 15 2 7 9 32 3739713.813 15102014.38 13367156.72 163654408.8 9 12 11 16 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;extracellular;membrane catalytic activity;protein binding "Pf00151, Pf01477, Pf12695, Pf12697" 16956 ENSMUSG00000015568.16 Lpl 8 Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling; Signaling by GPCR; Retinoid metabolism and transport PPAR signaling pathway; Alzheimer's disease; Glycerolipid metabolism 0 High Q8C804 Spindle and centriole-associated protein 1 OS=Mus musculus OX=10090 GN=Spice1 PE=1 SV=2 0 71.357 30 18 50 18 860 95.6 7.05 13 12 15 18 16 16 1364766.484 25529972.09 21108095.23 31900081.3 3 17 14 16 cell division;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton 212514 ENSMUSG00000043065.12 Spice1 16 0 High P27659 60S ribosomal protein L3 OS=Mus musculus OX=10090 GN=Rpl3 PE=1 SV=3 0 36.395 25 11 49 11 403 46.1 10.21 7 11 8 9 9 18 10 12 8193168.984 35949640.63 30892590.72 36287181.31 10 11 11 10 cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytosol;nucleus;ribosome RNA binding;structural molecule activity Pf00297 27367 ENSMUSG00000060036.13 Rpl3 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High E9QNN1 ATP-dependent RNA helicase A OS=Mus musculus OX=10090 GN=Dhx9 PE=1 SV=1 0 63.794 17 18 49 18 1384 149.6 6.83 3 14 11 10 5 16 14 14 6674529.313 23267138.48 18225740.5 20592308.59 11 18 17 16 cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;membrane;nucleus;ribosome catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717" 13211 ENSMUSG00000042699.11 Dhx9 1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activated TLR4 signalling; mRNA Splicing - Major Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; TRAF6 mediated NF-kB activation; Interleukin-1 family signaling 0 High D3Z6B9 Mitochondrial 10-formyltetrahydrofolate dehydrogenase OS=Mus musculus OX=10090 GN=Aldh1l2 PE=1 SV=1 0 24.977 10 9 49 4 810 88.8 5.58 5 5 9 16 16 17 179015.5469 364822.4063 354652.75 3677695.469 1 1 1 3 metabolic process cytoplasm;mitochondrion catalytic activity "Pf00171, Pf00550, Pf00551, Pf02911" 216188 ENSMUSG00000020256.14 Aldh1l2 10 0 High A0A3B2WDD2 Ribosomal protein OS=Mus musculus OX=10090 GN=Rpl10a PE=1 SV=1 0 41.454 37 8 49 8 190 21.6 9.98 3 8 5 7 5 18 11 15 9312078.563 33244936.88 25000562.37 34697242.78 8 9 9 9 0 High P15864 Histone H1.2 OS=Mus musculus OX=10090 GN=H1-2 PE=1 SV=2 0 32.244 39 10 49 3 212 21.3 11 7 8 9 5 9 17 18 5 10188851.81 60225883.13 68201140.06 23651698.19 6 8 10 8 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;protein binding;RNA binding Pf00538 50708 ENSMUSG00000036181.2 Hist1h1c 13 7 High P61358 60S ribosomal protein L27 OS=Mus musculus OX=10090 GN=Rpl27 PE=1 SV=2 0 38.756 45 6 49 6 136 15.8 10.56 4 5 6 5 8 14 14 13 9347391.313 37454393.19 32943758.19 37893441.38 6 6 6 7 metabolic process membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00467, Pf01777" 19942; 108167922 ENSMUSG00000063316.13; ENSMUSG00000073640.2 Rpl27; LOC108167922 11; 18 Ribosome 0 High A0A0R4J083 "Long-chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadl PE=1 SV=1" 0 62.915 36 14 48 14 430 47.9 8.15 5 10 6 14 6 12 7 23 25030599.13 55207069.45 47868810.06 115929222.6 11 14 13 14 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 11363 ENSMUSG00000026003.5 Acadl 1 Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA PPAR signaling pathway; Fatty acid metabolism; Metabolic pathways; Fatty acid degradation 0 High A2ACJ2 Fanconi anemia core complex-associated protein 100 OS=Mus musculus OX=10090 GN=Faap100 PE=2 SV=1 0 72.354 32 15 48 15 879 94.2 5.36 11 11 13 16 14 18 8981923.297 14454051.38 13984822 7 10 10 metabolic process;response to stimulus cytoskeleton;cytosol;nucleus DNA binding;protein binding Pf15146 71885 ENSMUSG00000025384.15 2310003H01Rik; Faap100 11 Fanconi Anemia Pathway Fanconi anemia pathway 0 High Q924X2 "Carnitine O-palmitoyltransferase 1, muscle isoform OS=Mus musculus OX=10090 GN=Cpt1b PE=1 SV=1" 0 88.099 31 22 48 22 772 88.2 8.38 3 1 22 4 2 42 606706.2656 3814483.555 3141960.211 67117569.7 4 9 9 22 metabolic process;transport membrane;mitochondrion catalytic activity Pf00755 12895 ENSMUSG00000078937.8 Cpt1b 15 Signaling by Retinoic Acid; Import of palmitoyl-CoA into the mitochondrial matrix PPAR signaling pathway; Fatty acid metabolism; Fatty acid degradation; Insulin resistance; Adipocytokine signaling pathway; AMPK signaling pathway; Glucagon signaling pathway 0 High Q8R081 Heterogeneous nuclear ribonucleoprotein L OS=Mus musculus OX=10090 GN=Hnrnpl PE=1 SV=2 0 56.162 37 14 48 14 586 63.9 8.1 2 10 9 13 2 16 13 17 6787722.359 24191949.31 23773743.19 27916008.44 9 14 14 14 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 15388 ENSMUSG00000015165.16 Hnrnpl 7 mRNA Splicing - Major Pathway 0 High P11983 T-complex protein 1 subunit alpha OS=Mus musculus OX=10090 GN=Tcp1 PE=1 SV=3 0 85.298 45 22 47 22 556 60.4 6.16 1 6 6 22 1 7 7 32 1053341.813 5545217.625 6184657.688 78089696.75 6 11 10 22 Acetyl [N-Term] metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi nucleotide binding;protein binding;RNA binding Pf00118 21454 ENSMUSG00000068039.12 Tcp1 17 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High P19096 Fatty acid synthase OS=Mus musculus OX=10090 GN=Fasn PE=1 SV=2 0 63 10 22 47 22 2504 272.3 6.58 3 15 11 15 4 15 11 17 6012250.016 13265512.63 11297092 16422985.08 20 20 20 19 cell differentiation;metabolic process;response to stimulus cytoplasm;cytosol;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08241, Pf08242, Pf08659, Pf12847, Pf13489, Pf13602, Pf13847, Pf14765" 14104 ENSMUSG00000025153.9 Fasn 11 ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism Fatty acid metabolism; Insulin signaling pathway; Metabolic pathways; AMPK signaling pathway; Fatty acid biosynthesis 0 High Q3UV17 "Keratin, type II cytoskeletal 2 oral OS=Mus musculus OX=10090 GN=Krt76 PE=1 SV=1" 0 23.131 8 8 47 2 594 62.8 8.43 6 6 7 8 12 11 12 12 71717348.16 125086121.8 133676530.8 107772823 2 2 2 2 nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf10473" 77055 ENSMUSG00000075402.1 Krt76 15 Formation of the cornified envelope 0 High Q9WTI7 Unconventional myosin-Ic OS=Mus musculus OX=10090 GN=Myo1c PE=1 SV=2 0 82.259 25 23 47 23 1063 121.9 9.35 9 9 21 9 10 28 1211037.375 8859351.469 13450765.09 44542003.66 5 14 15 20 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf06017" 17913 ENSMUSG00000017774.19 Myo1c 11 Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression 0 High Q9Z2X1 Heterogeneous nuclear ribonucleoprotein F OS=Mus musculus OX=10090 GN=Hnrnpf PE=1 SV=3 0 79.109 45 13 46 10 415 45.7 5.49 4 8 8 13 5 11 10 20 5656482.555 24115340.73 22838230.67 34940784.11 8 10 12 12 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 98758 ENSMUSG00000042079.13 Hnrnpf 6 mRNA Splicing - Major Pathway; FGFR2 alternative splicing 3 High A0A2R8VHP3 Predicted pseudogene 5478 OS=Mus musculus OX=10090 GN=Gm5478 PE=1 SV=1 0 21.243 11 7 46 2 535 57.9 6.2 6 5 6 6 9 15 12 10 34834502.66 49804642.66 45973540.81 46069830.38 4 4 4 4 0 High P83741 Serine/threonine-protein kinase WNK1 OS=Mus musculus OX=10090 GN=Wnk1 PE=1 SV=2 0 56.143 9 18 44 18 2377 250.8 6.43 13 10 16 13 11 20 2596043.516 23864423 16611660.2 28650671 2 15 13 16 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf09770, Pf12202" 232341 ENSMUSG00000045962.16 Wnk1 6 Stimuli-sensing channels 0 High P50544 "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadvl PE=1 SV=3" 0 87.816 37 19 44 19 656 70.8 8.75 5 6 6 18 5 7 6 26 5338883.844 13169824.52 13680791.27 40225533.19 12 12 14 17 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 11370 ENSMUSG00000018574.14 Acadvl 11 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Fatty acid metabolism; Metabolic pathways; Fatty acid degradation 0 High E9Q7B0 Prolyl 4-hydroxylase subunit alpha-1 OS=Mus musculus OX=10090 GN=P4ha1 PE=1 SV=1 0 88.099 39 18 44 1 454 51.7 6.71 1 5 3 18 1 6 3 34 379901.4688 2990163 1657466 3332340.75 1 1 1 1 cell organization and biogenesis;metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336, Pf13640" 18451 ENSMUSG00000019916.14 P4ha1 10 0 High P13707 "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Mus musculus OX=10090 GN=Gpd1 PE=1 SV=3" 0 65.015 45 13 43 13 349 37.5 7.17 4 8 6 13 5 10 8 20 7422763.063 19722836.78 12875522.25 44229197.75 9 11 11 12 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf01210, Pf07479" 14555 ENSMUSG00000023019.12 Gpd1 15 Synthesis of PA Glycerophospholipid metabolism 0 High Q9CQA3 "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Mus musculus OX=10090 GN=Sdhb PE=1 SV=1" 0 43.634 36 10 43 10 282 31.8 8.68 7 7 7 9 8 9 12 14 12395152.77 11462622.41 11437945.83 27707424.25 9 8 8 9 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding "Pf13085, Pf13183, Pf13534" 67680 ENSMUSG00000009863.14 Sdhb 4 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Carbon metabolism 0 High E9Q0F0 Keratin 78 OS=Mus musculus OX=10090 GN=Krt78 PE=1 SV=1 0 16.705 1 2 43 2 1068 112.2 7.97 2 1 2 2 11 10 12 10 54470303.75 70426526 62314057.25 50539340.25 3 3 3 3 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoskeleton;Golgi;membrane catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf01576, Pf02050, Pf02321, Pf02403, Pf03280, Pf03938, Pf04111, Pf04156, Pf04740, Pf04977, Pf05008, Pf05103, Pf05335, Pf05483, Pf05557, Pf05622, Pf05642, Pf05667, Pf05911, Pf06013, Pf06133, Pf06160, Pf06810, Pf07321, Pf07926, Pf08614, Pf09606, Pf09726, Pf09731, Pf09755, Pf11559, Pf11932, Pf12128, Pf12325, Pf12329, Pf12795, Pf13514, Pf13851, Pf14362, Pf15070, Pf15397" 332131 ENSMUSG00000050463.8 Krt78 15 Formation of the cornified envelope 0 High Q9Z2B5 Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Mus musculus OX=10090 GN=Eif2ak3 PE=1 SV=1 0 85.674 28 22 42 22 1114 124.6 5.25 11 2 20 14 2 26 55365.34375 17827362.58 6662899.797 37752541 1 16 12 18 cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf13360, Pf14531" 13666 Eif2ak3 6 Herpes simplex infection; Epstein-Barr virus infection; Non-alcoholic fatty liver disease (NAFLD); Influenza A; Hepatitis C; Alzheimer's disease; Protein processing in endoplasmic reticulum; Measles; Apoptosis 0 High E9QAQ7 AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 0 58.607 10 14 42 14 2287 242.5 6.71 4 12 11 7 4 15 14 9 45387931.73 54247740.91 66316433.88 13716162.53 12 13 13 12 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus DNA binding;protein binding "Pf01388, Pf12031" 93760 ENSMUSG00000007880.16 Arid1a 4 0 High Q62167 ATP-dependent RNA helicase DDX3X OS=Mus musculus OX=10090 GN=Ddx3x PE=1 SV=3 0 44.372 29 15 42 14 662 73.1 7.18 5 12 11 7 6 14 13 9 5509949.367 14082126.56 11055501.98 9777694.719 10 13 12 12 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 13205 ENSMUSG00000000787.12 Ddx3x X Neutrophil degranulation RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis 1 High D3Z7X0 "Acyl-Coenzyme A dehydrogenase family, member 12 OS=Mus musculus OX=10090 GN=Acad12 PE=1 SV=1" 0 66.222 31 17 41 17 555 61.4 9.36 11 7 16 12 8 21 8837973.547 20974426.56 17142893.83 35142247.88 4 13 14 15 metabolic process mitochondrion catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 338350 ENSMUSG00000042647.13 Acad12 5 Mitochondrial Fatty Acid Beta-Oxidation 0 High E9QN14 SLIT-ROBO Rho GTPase-activating protein 3 OS=Mus musculus OX=10090 GN=Srgap3 PE=1 SV=1 0 64.066 25 21 41 21 1075 121.6 6.57 16 14 9 17 15 9 854177.3438 22998384.06 23820608.83 20811234.45 2 18 20 18 regulation of biological process;response to stimulus cytoplasm enzyme regulator activity;protein binding "Pf00018, Pf00611, Pf00620, Pf07653, Pf14604" 259302 ENSMUSG00000030257.16 Srgap3 6 Rho GTPase cycle 0 High P19253 60S ribosomal protein L13a OS=Mus musculus OX=10090 GN=Rpl13a PE=1 SV=4 0 26.695 37 9 40 9 203 23.4 11.02 2 9 6 6 2 16 10 12 4410128.906 22073098.63 16801819.41 23017995.81 8 10 10 9 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00572 22121 ENSMUSG00000074129.13 Rpl13a 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8BFZ3 Beta-actin-like protein 2 OS=Mus musculus OX=10090 GN=Actbl2 PE=1 SV=1 0 36.185 22 6 40 1 376 42 5.49 2 3 4 6 6 6 8 20 704884.375 745875.4375 611096.1875 745207.8125 1 1 1 1 cytoplasm;cytoskeleton nucleotide binding Pf00022 238880 ENSMUSG00000055194.3 Actbl2 13 0 High S4R1W8 Glyceraldehyde-3-phosphate dehydrogenase (Fragment) OS=Mus musculus OX=10090 GN=Gapdh PE=1 SV=1 0 41.192 69 4 40 1 55 6.2 5.91 2 2 2 4 2 7 5 26 1174980 1 Met-loss [N-Term] metabolic process catalytic activity Pf00044 ENSMUSG00000057666.18 6 0 High Q3UID0 SWI/SNF complex subunit SMARCC2 OS=Mus musculus OX=10090 GN=Smarcc2 PE=1 SV=1 0 45.647 16 12 39 8 1130 124.6 5.47 9 7 7 9 9 9 10 11 5926947.953 8252951.844 6790207.5 7410926.031 9 9 9 9 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf04433 68094 ENSMUSG00000025369.15 Smarcc2 10 3 High P62830 60S ribosomal protein L23 OS=Mus musculus OX=10090 GN=Rpl23 PE=1 SV=1 0 51.407 51 8 39 8 140 14.9 10.51 2 6 6 8 4 9 8 18 8706063.75 31617776.81 29196380.38 126207038.1 6 8 8 9 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00238 65019; 100044627; 100862455 ENSMUSG00000071415.6 Rpl23; LOC100044627; LOC100862455 11; 17 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P35979 60S ribosomal protein L12 OS=Mus musculus OX=10090 GN=Rpl12 PE=1 SV=2 0 30.194 55 6 39 6 165 17.8 9.42 4 5 5 6 7 12 9 11 7742680.625 31161191 26593595.88 30800102.59 5 5 5 6 cell organization and biogenesis;metabolic process cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00298, Pf03946" 269261 ENSMUSG00000038900.17 Rpl12 2 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P27661 Histone H2AX OS=Mus musculus OX=10090 GN=H2ax PE=1 SV=2 0 10.029 38 5 38 2 143 15.1 10.74 3 5 5 2 6 14 13 5 562294.625 2940757.156 2948057.156 1 2 2 metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding "Pf00125, Pf00808" 15270 ENSMUSG00000049932.3 H2afx 9 G2/M DNA damage checkpoint; Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Nonhomologous End-Joining (NHEJ); Meiotic Synapsis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Alcoholism; Systemic lupus erythematosus 0 High Q3THW5 Histone H2A.V OS=Mus musculus OX=10090 GN=H2az2 PE=1 SV=3 0 11.607 31 4 38 2 128 13.5 10.58 4 3 3 3 8 11 12 7 3439499.375 8341866.75 8418670 4956791.75 2 2 2 2 regulation of biological process chromosome;nucleus DNA binding;protein binding Pf00125 77605 ENSMUSG00000041126.16 H2afv 11 Meiotic Recombination; Mus musculus biological processes; NoRC negatively regulates rRNA expression; Meiotic Synapsis Alcoholism; Systemic lupus erythematosus 0 High P14869 60S acidic ribosomal protein P0 OS=Mus musculus OX=10090 GN=Rplp0 PE=1 SV=3 0 49.186 30 8 38 8 317 34.2 6.25 3 7 7 8 4 10 10 14 4481214.773 22451338.56 19853332.75 26904886.13 6 6 6 7 response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00428, Pf00466" 11837 ENSMUSG00000067274.10 Rplp0 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q5SX75 Prolyl 4-hydroxylase subunit alpha-2 OS=Mus musculus OX=10090 GN=P4ha2 PE=1 SV=1 0 62.902 33 14 37 14 537 61 5.9 1 7 5 14 1 9 6 21 1212470 8485053.344 7734096.684 46393968.52 6 11 11 13 metabolic process cytosol;endoplasmic reticulum catalytic activity;metal ion binding;protein binding "Pf03171, Pf08336, Pf13640" 18452 ENSMUSG00000018906.14 P4ha2 11 Arginine and proline metabolism; Metabolic pathways 0 High Q9DB20 "ATP synthase subunit O, mitochondrial OS=Mus musculus OX=10090 GN=Atp5po PE=1 SV=1" 0 26.376 49 8 36 8 213 23.3 9.99 6 4 5 5 12 7 9 8 10078455.19 14913092.75 10192211.5 17567196.38 7 6 6 6 metabolic process;transport membrane;mitochondrion;nucleus catalytic activity;protein binding;transporter activity Pf00213 28080; 102641678 ENSMUSG00000022956.10 Atp5o; LOC100047429; LOC102641678 16; 3 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P35980 60S ribosomal protein L18 OS=Mus musculus OX=10090 GN=Rpl18 PE=1 SV=3 0 32.324 41 8 36 8 188 21.6 11.78 3 7 5 7 4 12 9 11 7032377.219 24498243.59 21457815.31 28977509.38 7 7 8 7 metabolic process cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00828 19899 ENSMUSG00000059070.16 Rpl18 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9D6Z1 Nucleolar protein 56 OS=Mus musculus OX=10090 GN=Nop56 PE=1 SV=2 0 47.966 33 15 36 15 580 64.4 9.14 7 8 8 10 9 8 9 10 5431524.359 8102109.586 6500283.969 9253969.797 11 12 9 11 metabolic process cytoplasm;membrane;nucleus protein binding;RNA binding "Pf01798, Pf08060, Pf08156" 67134 ENSMUSG00000027405.16 Nop56 2 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High Q99MR8 "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Mus musculus OX=10090 GN=Mccc1 PE=1 SV=2" 0 86.138 38 19 36 19 717 79.3 7.83 2 1 2 19 2 1 2 31 184047067 215667787.9 208667306.8 236282263.7 11 10 10 18 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding "Pf00289, Pf00364, Pf01071, Pf02222, Pf02785, Pf02786, Pf07478, Pf13533, Pf13535, Pf15632" 72039 ENSMUSG00000027709.9 Mccc1 3 Biotin transport and metabolism; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways" 0 High Q8BGS1 Band 4.1-like protein 5 OS=Mus musculus OX=10090 GN=Epb41l5 PE=1 SV=1 0 36.952 22 10 35 10 731 81.6 6.39 8 8 7 6 9 13 7 6 9633837.25 12324239.31 13513416.5 8547036.5 10 9 10 9 Acetyl [N-Term] cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity "Pf00373, Pf08736, Pf09379, Pf09380" 226352 ENSMUSG00000026383.14 Epb4.1l5; Epb41l5 1 Neurexins and neuroligins 0 High Q9JM93 ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Mus musculus OX=10090 GN=Arl6ip4 PE=1 SV=1 0 33.738 34 7 35 7 229 25.5 11.19 5 6 5 4 8 10 11 6 19764389.13 24751048.88 21360971.25 18651321.13 7 7 6 6 metabolic process nucleus protein binding;RNA binding Pf10500 65105 ENSMUSG00000029404.15 Arl6ip4 5 0 High P14148 60S ribosomal protein L7 OS=Mus musculus OX=10090 GN=Rpl7 PE=1 SV=2 0 34.54 43 11 35 11 270 31.4 10.89 3 9 7 10 3 10 8 14 3513845.852 24714585.18 22414569.45 32425136.66 7 11 11 13 Acetyl [N-Term] metabolic process cytoplasm;membrane;nucleus;ribosome DNA binding;protein binding;RNA binding;structural molecule activity "Pf00327, Pf08079" 19989 ENSMUSG00000043716.13 Rpl7 1 Ribosome 0 High Q9JJI8 60S ribosomal protein L38 OS=Mus musculus OX=10090 GN=Rpl38 PE=1 SV=3 0 30.479 53 7 35 7 70 8.2 10.1 2 6 4 7 3 10 6 16 9879358.316 18891731.95 12335871.28 46300268.5 6 7 5 7 cell organization and biogenesis;metabolic process;regulation of biological process ribosome RNA binding;structural molecule activity Pf01781 67671; 625646; 664868 ENSMUSG00000057322.12 Rpl38; Rpl38-ps1; Rpl38-ps2 11; 4; 6 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P17918 Proliferating cell nuclear antigen OS=Mus musculus OX=10090 GN=Pcna PE=1 SV=2 0 36.49 41 10 34 10 261 28.8 4.77 1 3 5 10 1 4 7 22 1335275.25 7994455 10818019.69 57157315.19 6 8 11 13 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding "Pf00705, Pf02747" 18538 ENSMUSG00000027342.14 Pcna 2 Termination of translesion DNA synthesis; Polymerase switching on the C-strand of the telomere; Translesion synthesis by POLI; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Polymerase switching; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Removal of the Flap Intermediate from the C-strand; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Translesion synthesis by REV1; HDR through Homologous Recombination (HRR); SUMOylation of DNA replication proteins DNA replication; Hepatitis B; HTLV-I infection; Nucleotide excision repair; Cell cycle; Base excision repair; Mismatch repair 0 High Q8CGN5 Perilipin-1 OS=Mus musculus OX=10090 GN=Plin1 PE=1 SV=2 0 37.816 29 11 34 11 517 55.6 7.01 4 9 7 7 5 12 9 8 5433189.141 12774850.7 9952510.383 11448847.81 8 9 8 9 metabolic process cytosol;endoplasmic reticulum protein binding Pf03036 103968 ENSMUSG00000030546.14 Plin1 7 PPAR signaling pathway; Regulation of lipolysis in adipocytes 0 High P43406 Integrin alpha-V OS=Mus musculus OX=10090 GN=Itgav PE=1 SV=2 0 86.411 28 24 34 24 1044 115.3 5.63 24 34 511812.5313 905868.7031 517984.0938 51890274.06 1 2 2 21 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;membrane;nucleus metal ion binding;protein binding;transporter activity "Pf01839, Pf08441, Pf13517" 16410 ENSMUSG00000027087.11 Itgav 2 ECM proteoglycans; Molecules associated with elastic fibres; Cross-presentation of particulate exogenous antigens (phagosomes); Integrin cell surface interactions; VEGFA-VEGFR2 Pathway; Neutrophil degranulation; Signal transduction by L1; Syndecan interactions Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Small cell lung cancer; Dilated cardiomyopathy; Cell adhesion molecules (CAMs); Phagosome; Proteoglycans in cancer; Thyroid hormone signaling pathway; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High P99027 60S acidic ribosomal protein P2 OS=Mus musculus OX=10090 GN=Rplp2 PE=1 SV=3 0 54.832 78 8 34 8 115 11.6 4.54 3 5 5 7 4 8 10 12 8112510.438 30518706.19 28227272.22 37289248 6 7 9 8 metabolic process membrane;ribosome structural molecule activity Pf00428 67186 ENSMUSG00000025508.13 Rplp2 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q7TNC4 Putative RNA-binding protein Luc7-like 2 OS=Mus musculus OX=10090 GN=Luc7l2 PE=1 SV=1 0 47.588 31 10 34 10 392 46.6 10.1 3 10 5 8 5 11 7 11 6335963.625 22454151.5 17892614.22 18145996.66 10 10 10 9 Met-loss+Acetyl [N-Term] cell organization and biogenesis nucleus;spliceosomal complex protein binding;RNA binding Pf03194 192196 ENSMUSG00000029823.16 Luc7l2 6 0 High Q8VIJ6 "Splicing factor, proline- and glutamine-rich OS=Mus musculus OX=10090 GN=Sfpq PE=1 SV=1" 0 33.997 19 11 34 10 699 75.4 9.44 5 9 10 5 5 11 12 6 4687531.344 18302368.88 11856223 4185136.75 6 9 8 4 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 71514 ENSMUSG00000028820.13 Sfpq 4 PTK6 Regulates Proteins Involved in RNA Processing 1 High Q8C570 mRNA export factor OS=Mus musculus OX=10090 GN=Rae1 PE=1 SV=1 0 37.141 35 10 34 10 368 40.9 7.83 9 8 7 13 11 10 449713892 566800812.1 425085128.2 576739373.9 3 9 9 9 cell division;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;nucleus protein binding;RNA binding Pf00400 66679 ENSMUSG00000027509.11 Rae1 2 Transcriptional regulation by small RNAs; SUMOylation of RNA binding proteins; snRNP Assembly; SUMOylation of chromatin organization proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins; SUMOylation of DNA replication proteins Influenza A; RNA transport 0 High P46978 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Mus musculus OX=10090 GN=Stt3a PE=1 SV=1 0 58.718 23 15 33 13 705 80.5 8.1 1 1 15 1 1 31 804957.8125 894368.5703 969953.3945 59491237.34 1 4 4 12 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf02516 16430 ENSMUSG00000032116.18 Stt3a 9 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 2 High Q91VT8 Small integral membrane protein 14 OS=Mus musculus OX=10090 GN=Smim14 PE=1 SV=1 0 53.115 57 3 33 3 99 10.7 5.73 2 2 3 4 3 26 5796604.047 5521036 259410718.1 4 4 6 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] endoplasmic reticulum;membrane Pf11027 68552 ENSMUSG00000037822.12 1110003E01Rik; Smim14 5 0 High P97351 40S ribosomal protein S3a OS=Mus musculus OX=10090 GN=Rps3a PE=1 SV=3 0 25.339 22 7 33 7 264 29.9 9.73 4 5 5 6 6 9 10 8 4058655.781 17537894.75 15358721.19 16979104.5 6 7 7 7 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01015 20091 ENSMUSG00000028081.6 Rps3a; Rps3a1 3 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P61514 60S ribosomal protein L37a OS=Mus musculus OX=10090 GN=Rpl37a PE=1 SV=2 0 27.767 41 3 33 3 92 10.3 10.43 3 3 3 3 8 9 8 8 15448012 20138385.63 21633705.5 17924791.63 3 3 3 3 metabolic process nucleus;ribosome metal ion binding;RNA binding;structural molecule activity Pf01780 19981 ENSMUSG00000046330.10 Rpl37a 1 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q6ZWN5 40S ribosomal protein S9 OS=Mus musculus OX=10090 GN=Rps9 PE=1 SV=3 0 17.609 40 9 33 9 194 22.6 10.65 3 7 6 6 4 11 10 8 4093248.813 23518513.83 19762422.84 20908896.88 5 9 9 9 metabolic process;regulation of biological process cytoplasm;membrane;nucleus;ribosome RNA binding;structural molecule activity;translation regulator activity "Pf00163, Pf01479" 76846 ENSMUSG00000006333.14 Rps9 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High A0A0A0MQ73 Histone-lysine N-methyltransferase 2D OS=Mus musculus OX=10090 GN=Kmt2d PE=1 SV=1 0 32.562 4 13 32 13 5588 599.9 5.78 3 8 13 2 3 11 16 2 3699320.313 9649830.813 9177254.781 5940700.188 9 12 12 11 cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00505, Pf00628, Pf00856, Pf05964, Pf05965, Pf13639, Pf13771, Pf13832, Pf15446" 381022 ENSMUSG00000048154.16 Kmt2d; Mll2 15 Lysine degradation 0 High Q924H2 Mediator of RNA polymerase II transcription subunit 15 OS=Mus musculus OX=10090 GN=Med15 PE=1 SV=3 0 39.468 12 7 32 7 789 86.6 9.29 2 7 5 6 2 12 9 9 773360.25 11586689.03 9740504.844 12646951.31 2 7 6 6 0 High Q9JJZ4 Ubiquitin-conjugating enzyme E2 J1 OS=Mus musculus OX=10090 GN=Ube2j1 PE=1 SV=2 0 56.942 38 10 32 10 318 35 6.99 1 1 10 1 1 30 1083612.516 851186.3906 61363931.63 4 3 10 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding Pf00179 56228 ENSMUSG00000028277.13 Ube2j1 4 Ubiquitin mediated proteolysis; Parkinson's disease; Protein processing in endoplasmic reticulum 0 High A0A1L1STE6 "Isocitrate dehydrogenase [NAD] subunit, mitochondrial OS=Mus musculus OX=10090 GN=Idh3a PE=1 SV=1" 0 44.309 26 9 32 9 384 41.5 6.93 5 5 5 8 5 6 6 15 7165187.734 17802958.12 13224659.86 39174227.25 7 10 9 10 metabolic process mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00180 ENSMUSG00000032279.11 9 0 High O88569 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Mus musculus OX=10090 GN=Hnrnpa2b1 PE=1 SV=2 0 42.728 39 13 32 10 353 37.4 8.95 9 7 6 7 9 7 8 8 13569535.02 15063621.75 14822510.56 21988989.44 11 10 11 11 cell organization and biogenesis;metabolic process;regulation of biological process;transport chromosome;cytoplasm;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 53379 ENSMUSG00000004980.16 Hnrnpa2b1 6 mRNA Splicing - Major Pathway 3 High P47963 60S ribosomal protein L13 OS=Mus musculus OX=10090 GN=Rpl13 PE=1 SV=3 0 24.58 41 8 32 8 211 24.3 11.55 2 7 6 5 3 10 10 9 6577198.766 27621574 23086399.5 25861878.56 7 8 8 7 metabolic process membrane;nucleus;ribosome RNA binding;structural molecule activity Pf01294 270106 ENSMUSG00000000740.12 Rpl13 8 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q497W9 DEAH (Asp-Glu-Ala-His) box polypeptide 15 OS=Mus musculus OX=10090 GN=Dhx15 PE=1 SV=1 0 23.543 13 9 32 9 703 79.9 7.3 1 6 8 6 2 10 10 10 3723440 12805422.63 10846960.72 16875482.19 7 9 9 9 metabolic process cytoplasm;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717, Pf13401" 13204 ENSMUSG00000029169.11 Dhx15 5 0 High Q60597 "2-oxoglutarate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Ogdh PE=1 SV=3" 0 28.511 16 12 32 12 1023 116.4 6.83 5 3 6 11 7 3 7 15 9391108.375 6789057.406 9032513.406 13941760.91 12 11 12 12 cellular component movement;metabolic process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00676, Pf02779" 18293 ENSMUSG00000020456.17 Ogdh 11 Lysine catabolism; Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation Tryptophan metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Lysine degradation; Carbon metabolism 0 High Q8BP27 Swi5-dependent recombination DNA repair protein 1 homolog OS=Mus musculus OX=10090 GN=Sfr1 PE=1 SV=2 0 38.401 39 9 32 9 319 35.2 5.15 6 5 5 12 10 10 17771496.19 19808007.41 17415772.44 8 9 8 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus nucleus Pf10376 67788 ENSMUSG00000025066.9 Sfr1 19 0 High Q3U3J1 2-oxoisovalerate dehydrogenase subunit alpha OS=Mus musculus OX=10090 GN=Bckdha PE=1 SV=1 0 45.141 29 10 31 10 446 50.7 8.06 1 7 6 10 1 8 7 15 2357702.961 6654792.125 7273538.625 23733281.63 8 7 8 10 metabolic process mitochondrion catalytic activity;metal ion binding;protein binding "Pf00456, Pf00676" 12039 ENSMUSG00000060376.7 Bckdha 7 Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism" 0 High P16627 Heat shock 70 kDa protein 1-like OS=Mus musculus OX=10090 GN=Hspa1l PE=1 SV=4 0 27.332 10 5 31 1 641 70.6 6.24 4 4 4 5 6 8 6 11 424871.375 372881.375 375295.9688 1 1 1 cell differentiation;cell organization and biogenesis;development;metabolic process cytosol;mitochondrion;organelle lumen nucleotide binding;protein binding "Pf00012, Pf06723" 15482 ENSMUSG00000007033.4 Hspa1l 17 HSF1-dependent transactivation Endocytosis; MAPK signaling pathway; Toxoplasmosis; Epstein-Barr virus infection; Spliceosome; Legionellosis; Influenza A; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Measles; Longevity regulating pathway - multiple species 0 High P29341 Polyadenylate-binding protein 1 OS=Mus musculus OX=10090 GN=Pabpc1 PE=1 SV=2 0 36.89 20 11 31 11 636 70.6 9.5 3 10 6 4 4 15 8 4 4383556.063 14470322.5 11209990.69 7860925.531 8 9 8 8 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf00658, Pf13893, Pf14259" 18458 ENSMUSG00000022283.14 Pabpc1 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Translation initiation complex formation; Deadenylation of mRNA mRNA surveillance pathway; RNA degradation; RNA transport 0 High Q9CZU6 "Citrate synthase, mitochondrial OS=Mus musculus OX=10090 GN=Cs PE=1 SV=1" 0 21.774 16 7 30 7 464 51.7 8.57 3 6 5 4 3 9 9 9 8007112.203 15494638.38 13568026.31 21740526.31 6 7 6 7 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity;RNA binding Pf00285 12974 ENSMUSG00000005683.8 Cs 10 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High P62751 60S ribosomal protein L23a OS=Mus musculus OX=10090 GN=Rpl23a PE=1 SV=1 0 18.28 33 7 30 7 156 17.7 10.45 4 6 5 4 6 9 9 6 4959264.219 17897975 14456838.25 16481564.63 7 6 6 6 cell organization and biogenesis;metabolic process nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00276, Pf03939" 268449 ENSMUSG00000058546.8 Rpl23a 11 Ribosome 0 High O08749 "Dihydrolipoyl dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Dld PE=1 SV=2" 0 51.789 28 11 30 11 509 54.2 7.9 1 4 3 11 1 5 4 20 1040438.938 5135955.813 5559486.953 28490845.25 3 7 7 9 cellular homeostasis;metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00070, Pf00890, Pf01134, Pf01946, Pf02852, Pf03486, Pf07992, Pf12831, Pf13450" 13382 ENSMUSG00000020664.10 Dld 12 Glycine degradation; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Branched-chain amino acid catabolism "Pyruvate metabolism; Citrate cycle (TCA cycle); Valine, leucine and isoleucine degradation; Metabolic pathways; Glycine, serine and threonine metabolism; Glycolysis / Gluconeogenesis; Propanoate metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High Q9D051 "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Pdhb PE=1 SV=1" 0 60.787 51 12 30 12 359 38.9 6.87 2 4 4 12 2 4 5 19 5915538.281 11821809.44 11388017.34 49360085.84 6 7 7 11 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity "Pf02779, Pf02780" 68263 ENSMUSG00000021748.8 Pdhb 14 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 0 High Q61656 Probable ATP-dependent RNA helicase DDX5 OS=Mus musculus OX=10090 GN=Ddx5 PE=1 SV=2 0 39.824 22 12 30 7 614 69.2 8.92 3 6 9 8 3 7 11 9 4682679.359 11372010.88 10859473.34 8801565.719 8 8 9 8 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;spliceosomal complex catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08061" 13207 Ddx5 11 4 High Q8BG05 Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus OX=10090 GN=Hnrnpa3 PE=1 SV=1 0 37.267 25 9 29 8 379 39.6 9.01 4 7 7 4 6 10 8 5 10431964.41 17103503 14761626.84 14187140.83 5 6 6 7 metabolic process;transport cytoplasm;nucleus;spliceosomal complex RNA binding;transporter activity "Pf00076, Pf13893, Pf14259" 229279 ENSMUSG00000059005.13 Hnrnpa3 2 Spliceosome 0 High P43274 Histone H1.4 OS=Mus musculus OX=10090 GN=H1-4 PE=1 SV=2 0 20.557 32 8 29 3 219 22 11.11 5 7 6 4 6 10 9 4 2505658 12474681.25 12682126.59 3834566.25 2 3 3 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process chromosome;nucleus DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding Pf00538 50709 ENSMUSG00000051627.2 Hist1h1e 13 0 High G5E902 "Phosphate carrier protein, mitochondrial OS=Mus musculus OX=10090 GN=Slc25a3 PE=1 SV=1" 0 25.511 25 9 29 9 358 39.7 9.29 1 4 4 9 1 4 6 18 1480666.656 5903942.344 5281192.031 53692423.47 6 8 6 11 transport membrane;mitochondrion protein binding;transporter activity Pf00153 18674 ENSMUSG00000061904.12 Slc25a3 10 0 High Q921R2 40S ribosomal protein S13 OS=Mus musculus OX=10090 GN=Rps13 PE=1 SV=1 0 17.534 41 7 29 7 140 16.1 10.71 4 5 6 5 6 7 10 6 14321740.56 26458563.03 25999107.66 22408625.38 6 7 7 6 metabolic process;regulation of biological process membrane;nucleus;ribosome RNA binding;structural molecule activity "Pf00312, Pf08069" 68052 ENSMUSG00000090862.3 Rps13 7 0 High Q8C2Q7 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus OX=10090 GN=Hnrnph1 PE=1 SV=1 0 41.148 20 7 29 4 472 51.2 6.8 4 6 6 6 6 8 8 7 1098319.656 4341305.25 4617884.25 5210542.25 2 4 4 4 metabolic process;regulation of biological process cytosol;membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08080, Pf14259" 59013 ENSMUSG00000007850.16 Hnrnph1 11 0 High P35564 Calnexin OS=Mus musculus OX=10090 GN=Canx PE=1 SV=1 0 66.053 27 13 29 13 591 67.2 4.64 13 29 1744524.563 970191.7422 620709.9844 43337816.25 3 4 3 12 metabolic process;transport cytoplasm;endoplasmic reticulum;membrane;ribosome metal ion binding;protein binding;RNA binding Pf00262 12330 ENSMUSG00000020368.15 Canx 11 "Calnexin/calreticulin cycle; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; Interleukin-35 Signalling" HTLV-I infection; Thyroid hormone synthesis; Phagosome; Antigen processing and presentation; Protein processing in endoplasmic reticulum 0 High Q8VED5 "Keratin, type II cytoskeletal 79 OS=Mus musculus OX=10090 GN=Krt79 PE=1 SV=2" 0 22.1 8 7 28 1 531 57.5 7.69 4 4 4 6 6 7 7 8 30647223.06 27461909.84 23866720.19 21798223.13 2 2 2 2 catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf13166" 223917 ENSMUSG00000061397.7 Krt79 15 Formation of the cornified envelope 0 High P62918 60S ribosomal protein L8 OS=Mus musculus OX=10090 GN=Rpl8 PE=1 SV=2 0 34.719 39 6 28 6 257 28 11.03 3 5 3 5 3 9 6 10 5926491.656 22789975.63 19322368.13 36824049.13 5 5 5 5 metabolic process;response to stimulus cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity "Pf00181, Pf03947" 26961 ENSMUSG00000003970.8 Rpl8 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q6NV83 U2 snRNP-associated SURP motif-containing protein OS=Mus musculus OX=10090 GN=U2surp PE=1 SV=3 0 31.467 11 9 28 9 1029 118.2 8.47 5 9 4 5 7 10 6 5 4605506.813 9946185.938 7357442.5 6917670.281 7 8 7 8 metabolic process nucleus RNA binding "Pf00076, Pf01805, Pf08312, Pf13893, Pf14259" 67958 ENSMUSG00000032407.14 U2surp 9 mRNA Splicing - Major Pathway Spliceosome 0 High A6BLY7 "Keratin, type I cytoskeletal 28 OS=Mus musculus OX=10090 GN=Krt28 PE=1 SV=1" 0 7.12 5 3 28 1 462 50.3 5.29 2 3 3 3 5 9 7 7 22944192.38 67630519.63 47284926.25 53120458 2 2 2 2 cytoplasm structural molecule activity Pf00038 70843 ENSMUSG00000055937.1 Krt28 11 Formation of the cornified envelope 0 High E9Q9B3 SPRY domain-containing 3 OS=Mus musculus OX=10090 GN=Spryd3 PE=1 SV=1 0 30.227 32 9 28 9 442 49.7 6.16 7 4 7 9 7 12 155181.7148 13774555.38 12061362.53 15365311.31 2 8 8 8 protein binding Pf00622 223918 ENSMUSG00000036966.15 Spryd3 15 0 High Q6PD21 SH2 domain-containing adapter protein B OS=Mus musculus OX=10090 GN=Shb PE=1 SV=2 0 31.558 24 9 28 9 503 54.7 8.78 7 8 4 10 13 5 523667.25 22287353.94 19288514.81 16684712.44 2 8 7 6 cell death;cell differentiation;cell proliferation;development;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding Pf00017 230126 ENSMUSG00000044813.15 Shb 4 VEGFA-VEGFR2 Pathway; EPHB-mediated forward signaling 0 High Q3TML0 Protein disulfide-isomerase A6 OS=Mus musculus OX=10090 GN=Pdia6 PE=1 SV=1 0 60.277 38 10 28 10 445 48.7 5.19 2 3 2 10 3 4 3 18 4691579.594 3756862.195 1203714.977 31524762.06 7 6 3 9 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;membrane;organelle lumen catalytic activity "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 71853 ENSMUSG00000020571.12 Pdia6 12 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation Protein processing in endoplasmic reticulum 0 High P62242 40S ribosomal protein S8 OS=Mus musculus OX=10090 GN=Rps8 PE=1 SV=2 0 33.001 42 7 27 7 208 24.2 10.32 1 7 6 6 1 9 8 9 4227777.844 22079061.19 18925242.25 21966871.44 6 7 7 7 metabolic process cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf01201 20116; 100040298 ENSMUSG00000047675.15 Rps8; Gm15501 4; 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q60584 F-box/WD repeat-containing protein 2 OS=Mus musculus OX=10090 GN=Fbxw2 PE=2 SV=2 0 41.319 22 8 27 8 422 47.9 6.79 4 6 6 8 9 10 15522710.19 14968889.41 16864882.63 6 7 7 metabolic process cytoplasm;nucleus catalytic activity;protein binding "Pf00400, Pf12937" 30050 Fbxw2 2 0 High Q8K2F0 Bromodomain-containing protein 3 OS=Mus musculus OX=10090 GN=Brd3 PE=1 SV=2 0 23.329 11 8 27 4 726 79.7 9.36 6 6 5 3 8 8 7 4 9723535.813 8243315.438 6756182.313 6430196.219 7 7 7 7 cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding Pf00439 67382 ENSMUSG00000026918.16 Brd3 2 4 High Q9JKR6 Hypoxia up-regulated protein 1 OS=Mus musculus OX=10090 GN=Hyou1 PE=1 SV=1 0 67.669 21 16 27 16 999 111.1 5.19 16 27 484568.1484 689231.5156 28483700.44 3 3 14 regulation of biological process;response to stimulus;transport endoplasmic reticulum;extracellular;membrane;organelle lumen nucleotide binding Pf00012 12282 ENSMUSG00000032115.14 Hyou1 9 Protein processing in endoplasmic reticulum 0 High P62908 40S ribosomal protein S3 OS=Mus musculus OX=10090 GN=Rps3 PE=1 SV=1 0 29.647 37 9 27 9 243 26.7 9.66 6 7 9 6 8 13 3147487.125 12220348.5 11015571.59 28398294.13 5 7 8 8 cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity "Pf00189, Pf07650" 27050 ENSMUSG00000030744.13 Rps3 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9R0E1 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Mus musculus OX=10090 GN=Plod3 PE=1 SV=1 0 54.479 21 12 27 11 741 84.9 6.23 4 2 12 4 2 21 1317566.418 3373039.414 3954721.188 22360388.53 6 9 8 11 cell organization and biogenesis;metabolic process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding Pf03171 26433 ENSMUSG00000004846.10 Plod3 5 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 1 High Q8BP67 60S ribosomal protein L24 OS=Mus musculus OX=10090 GN=Rpl24 PE=1 SV=2 0 17.355 36 6 26 6 157 17.8 11.25 4 5 4 5 5 8 6 7 21142194.38 20466522.84 18033245.75 26521385.75 5 6 5 5 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01246 68193 ENSMUSG00000098274.7 Rpl24 16 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8VCD5 Mediator of RNA polymerase II transcription subunit 17 OS=Mus musculus OX=10090 GN=Med17 PE=1 SV=1 0 20.978 14 7 26 7 649 72.4 7.3 1 4 4 7 1 9 8 8 1658837.5 6956947.438 6457016.438 8516094.188 5 6 6 6 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;protein binding;receptor activity Pf10156 234959 ENSMUSG00000031935.9 Med17 9 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway 0 High P25444 40S ribosomal protein S2 OS=Mus musculus OX=10090 GN=Rps2 PE=1 SV=3 0 26.796 31 9 26 9 293 31.2 10.24 1 8 6 7 1 10 6 9 2882289.422 13435616.31 9782443.5 14469482.5 6 7 5 7 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00333, Pf03719" 16898; 546298 ENSMUSG00000044533.15 Rps2; Rps2-ps13 17; X Ribosome 0 High Q9CR57 60S ribosomal protein L14 OS=Mus musculus OX=10090 GN=Rpl14 PE=1 SV=3 0 20.353 20 4 26 4 217 23.5 11.02 2 3 3 4 4 7 7 8 5396024.656 19942584.03 19090726.19 24653982.56 3 4 4 4 metabolic process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01929 67115 ENSMUSG00000025794.9 Rpl14 9 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High O54774 AP-3 complex subunit delta-1 OS=Mus musculus OX=10090 GN=Ap3d1 PE=1 SV=1 0 34.036 12 11 26 11 1199 135 7.37 7 8 8 2 8 8 8 2 5330411.859 7655139.25 7511919.844 7102393.531 11 10 10 10 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;Golgi;membrane "Pf01602, Pf06375" 11776 ENSMUSG00000020198.8 Ap3d1 10 Lysosome 0 High Q9WTX5 S-phase kinase-associated protein 1 OS=Mus musculus OX=10090 GN=Skp1 PE=1 SV=3 0 53.562 74 9 26 9 163 18.7 4.54 5 6 9 8 7 11 178408.7969 27286612.94 25100502.78 41150295.53 1 8 10 9 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf01466, Pf03931" 21402 ENSMUSG00000036309.14 Skp1a 11 NIK-->noncanonical NF-kB signaling; Degradation of beta-catenin by the destruction complex; Prolactin receptor signaling; SCF-beta-TrCP mediated degradation of Emi1; Regulation of RUNX2 expression and activity; SCF(Skp2)-mediated degradation of p27/p21; Neddylation; GLI3 is processed to GLI3R by the proteasome; Dectin-1 mediated noncanonical NF-kB signaling; Activation of NF-kappaB in B cells; Activated TLR4 signalling; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Regulation of PLK1 Activity at G2/M Transition; Downstream TCR signaling; Cyclin D associated events in G1; Interleukin-1 family signaling; Iron uptake and transport; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; MAP3K8 (TPL2)-dependent MAPK1/3 activation Herpes simplex infection; Wnt signaling pathway; Ubiquitin mediated proteolysis; Circadian rhythm; Oocyte meiosis; Cell cycle; TGF-beta signaling pathway; Protein processing in endoplasmic reticulum 0 High Q3ULD5 "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Mus musculus OX=10090 GN=Mccc2 PE=1 SV=1" 0 62.104 31 12 26 12 563 61.3 8 1 3 4 12 1 3 4 18 6230599.688 4037414.844 4727317.984 25164581.5 10 6 7 11 metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf01039, Pf03255" 78038 ENSMUSG00000021646.8 Mccc2 13 Biotin transport and metabolism; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways" 0 High Q9WTX2 Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Mus musculus OX=10090 GN=Prkra PE=1 SV=1 0 30.781 28 7 26 7 313 34.3 8.43 1 6 4 6 1 10 6 9 1781816.883 10291696.44 7589017.906 10427840.81 5 7 6 6 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf00035, Pf14709" 23992 ENSMUSG00000002731.6 Prkra 2 MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis 0 High Q569Z5 Probable ATP-dependent RNA helicase DDX46 OS=Mus musculus OX=10090 GN=Ddx46 PE=1 SV=2 0 29.718 18 15 26 15 1032 117.4 9.26 6 10 4 5 6 10 4 6 6289992.133 12687454.78 7947553.25 9064382.281 11 14 11 11 metabolic process;regulation of biological process cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271" 212880 ENSMUSG00000021500.15 Ddx46 13 mRNA Splicing - Major Pathway Spliceosome 0 High O54991 Contactin-associated protein 1 OS=Mus musculus OX=10090 GN=Cntnap1 PE=1 SV=2 0 49.712 11 14 26 14 1385 156.2 7.06 3 2 14 3 2 21 210745.8867 5688250.547 2035350.156 30109547.88 2 10 6 13 cell organization and biogenesis membrane protein binding "Pf00054, Pf00147, Pf00754, Pf02210" 53321 ENSMUSG00000017167.6 Cntnap1 11 Cell adhesion molecules (CAMs) 0 High P82349 Beta-sarcoglycan OS=Mus musculus OX=10090 GN=Sgcb PE=1 SV=1 0 74.005 46 11 25 11 320 34.9 8.6 11 25 551100.4609 11799407.6 10459946.72 56290069.19 3 4 4 12 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;membrane Pf04790 24051 ENSMUSG00000029156.11 Sgcb 5 Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Viral myocarditis 0 High O70571 "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial OS=Mus musculus OX=10090 GN=Pdk4 PE=1 SV=1" 0 56.398 46 13 25 13 412 46.6 7.08 3 2 13 3 2 20 168295.9063 2381859.359 2459031.484 43777841.75 1 5 6 11 cell communication;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf02518, Pf10436" 27273 ENSMUSG00000019577.6 Pdk4 6 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid 0 High Q9CQN1 "Heat shock protein 75 kDa, mitochondrial OS=Mus musculus OX=10090 GN=Trap1 PE=1 SV=1" 0 72.384 34 17 25 16 706 80.2 6.68 1 2 17 1 2 22 5674462.703 14403754.31 14001817.25 43839362.83 5 8 10 13 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;organelle lumen nucleotide binding;protein binding;RNA binding "Pf00183, Pf02518, Pf13589" 68015 ENSMUSG00000005981.11 Trap1 16 1 High P62960 Y-box-binding protein 1 OS=Mus musculus OX=10090 GN=Ybx1 PE=1 SV=3 0 40.529 47 6 25 4 322 35.7 9.88 3 6 6 2 4 9 9 3 2505954.219 12413184.88 8327508.563 6684273.563 4 7 5 5 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding Pf00313 22608 ENSMUSG00000028639.14 Ybx1 4 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway 3 High Q9Z2T6 "Keratin, type II cuticular Hb5 OS=Mus musculus OX=10090 GN=Krt85 PE=1 SV=2" 0 7.159 4 2 25 1 507 55.7 6.42 2 2 1 1 4 7 7 7 685580.5 494688.7813 1 1 structural molecule activity Pf00038 53622 Krt85 15 0 High Q3TKT4 Transcription activator BRG1 OS=Mus musculus OX=10090 GN=Smarca4 PE=1 SV=1 0 33.916 6 8 25 8 1613 181.3 8 6 7 5 4 6 8 6 5 6622214.125 8735962.188 4889890.031 7588188.938 7 8 7 7 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619" 20586 ENSMUSG00000032187.16 Smarca4 9 Interleukin-7 signaling; RMTs methylate histone arginines; Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 High Q9CQM8 60S ribosomal protein L21 OS=Mus musculus OX=10090 GN=Rpl21 PE=1 SV=1 0 19.396 21 4 25 4 160 18.6 10.49 2 3 4 4 4 6 7 8 4036309.5 17914424.31 15571391.44 19790137.5 4 4 4 4 metabolic process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01157 19933; 676253; 100503563; 675278 ENSMUSG00000041453.12 Rpl21; Gm14648; Gm10240; Rpl21-ps15 5; X; 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q6P8N8 "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Mus musculus OX=10090 GN=Clpx PE=1 SV=1" 0 62.473 35 16 25 16 620 67.3 7.55 1 2 15 1 2 22 492475.2578 3648701.492 4402330.207 32537030.56 4 9 9 14 metabolic process;regulation of biological process cytosol;membrane;mitochondrion;organelle lumen catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf00158, Pf01078, Pf05729, Pf07724, Pf07726, Pf07728, Pf10431, Pf13191, Pf13401, Pf14532" 270166 ENSMUSG00000015357.10 Clpx 9 0 High Q8CFI7 DNA-directed RNA polymerase II subunit RPB2 OS=Mus musculus OX=10090 GN=Polr2b PE=1 SV=2 0 39.135 14 12 25 12 1174 133.8 6.87 7 8 8 8 9 8 159069.2813 4920401.859 5410417.945 7926870.5 1 9 9 9 metabolic process membrane;nucleus catalytic activity;DNA binding;metal ion binding;RNA binding "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" 231329 ENSMUSG00000029250.5 Polr2b 5 mRNA Capping; RNA Polymerase II Transcription Initiation; Transcriptional regulation by small RNAs; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; RNA Pol II CTD phosphorylation and interaction with CE; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Dual incision in TC-NER; RNA polymerase II transcribes snRNA genes; Formation of the Early Elongation Complex; TP53 Regulates Transcription of DNA Repair Genes; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Purine metabolism; Huntington's disease; Pyrimidine metabolism 0 High Q6ZWY3 40S ribosomal protein S27-like OS=Mus musculus OX=10090 GN=Rps27l PE=1 SV=3 0 25.451 42 5 25 2 84 9.5 9.45 2 3 2 5 2 4 4 15 2330905.125 8176030.313 8824235.188 25798184.75 2 4 4 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus;ribosome enzyme regulator activity;metal ion binding;RNA binding;structural molecule activity;translation regulator activity Pf01667 67941 ENSMUSG00000036781.13 Rps27l 9 4 High A2AR02 Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 0 14.958 5 4 25 4 752 88.3 10.27 4 4 3 3 6 8 6 5 5694462.453 8546577.688 7876349.625 6119954.055 4 4 4 4 metabolic process cytosol;nucleus catalytic activity;RNA binding Pf00160 228005 ENSMUSG00000042133.16 Ppig 2 0 High Q8BH95 "Enoyl-CoA hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Echs1 PE=1 SV=1" 0 28.704 26 7 25 7 290 31.5 8.48 3 5 6 5 5 7 7 6 8462613.938 8752008.563 10072572.78 14962148.88 8 6 8 7 metabolic process mitochondrion;organelle lumen catalytic activity Pf00378 93747 ENSMUSG00000025465.13 Echs1 7 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; beta-Alanine metabolism; Propanoate metabolism; Fatty acid elongation; Carbon metabolism" 0 High P17182 Alpha-enolase OS=Mus musculus OX=10090 GN=Eno1 PE=1 SV=3 0 53.195 26 9 25 8 434 47.1 6.8 1 6 4 8 1 6 4 14 3207357.766 6500725.719 6170014.813 24322655.13 6 6 6 8 metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00113, Pf03952, Pf13378" 13806; 433182 ENSMUSG00000059040.4; ENSMUSG00000063524.13 Eno1; Gm5506; Eno1b 4; 18 Gluconeogenesis; Glycolysis RNA degradation; Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism 1 High P43276 Histone H1.5 OS=Mus musculus OX=10090 GN=H1-5 PE=1 SV=2 0 18.791 26 6 25 5 223 22.6 10.92 3 6 5 2 5 10 8 2 3032435.063 19320402.97 20435374.31 4613995.766 3 6 6 4 Met-loss [N-Term]; Met-loss+Acetyl [N-Term] cell organization and biogenesis chromosome;nucleus DNA binding;protein binding Pf00538 56702 ENSMUSG00000058773.2 Hist1h1b 13 0 High Q9CPR4 60S ribosomal protein L17 OS=Mus musculus OX=10090 GN=Rpl17 PE=1 SV=3 0 40.335 38 7 25 7 184 21.4 10.18 2 6 5 3 2 10 6 7 3362197.875 16776947.19 12201680.48 15781606.69 5 8 8 5 metabolic process;regulation of biological process nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00237 319195 Rpl17 18 0 High Q9D9N8 Protease-associated domain-containing protein 1 OS=Mus musculus OX=10090 GN=Pradc1 PE=1 SV=1 0 29.616 49 8 24 8 188 21.1 5.72 4 2 8 4 2 18 3699716.516 2604681.063 194029778.6 4 3 8 extracellular Pf02225 73327 ENSMUSG00000030008.9 Pradc1 6 0 High Z4YJW0 ER membrane protein complex subunit 1 OS=Mus musculus OX=10090 GN=Emc1 PE=1 SV=1 0 67.723 24 18 24 18 997 111.5 7.43 18 24 631357.1719 765702.2188 30921375.56 2 2 14 "Pf07774, Pf13360" ENSMUSG00000078517.11 4 0 High Q02257 Junction plakoglobin OS=Mus musculus OX=10090 GN=Jup PE=1 SV=3 0 22.218 13 8 24 8 745 81.7 6.14 4 8 5 5 6 8 5 5 4904960.063 6298168.188 5948301.875 4162443.906 8 8 8 7 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;signal transducer activity;structural molecule activity Pf00514 16480 ENSMUSG00000001552.14 Jup 11 Formation of the cornified envelope; VEGFR2 mediated vascular permeability; Neutrophil degranulation; Adherens junctions interactions Acute myeloid leukemia; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Transcriptional misregulation in cancer; Pathways in cancer 0 High Q8CGK3 "Lon protease homolog, mitochondrial OS=Mus musculus OX=10090 GN=Lonp1 PE=1 SV=2" 0 46.175 21 13 24 13 949 105.8 6.57 3 3 4 12 3 3 4 14 2913994.438 7964266.906 6604743.75 17596186.38 5 9 8 10 cell organization and biogenesis;metabolic process;response to stimulus cytosol;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01695, Pf02190, Pf05362, Pf05496, Pf07724, Pf07726, Pf07728, Pf08298, Pf13173, Pf13191, Pf13207, Pf13401, Pf13541" 74142 ENSMUSG00000041168.9 Lonp1 17 0 High P49312 Heterogeneous nuclear ribonucleoprotein A1 OS=Mus musculus OX=10090 GN=Hnrnpa1 PE=1 SV=2 0 33.497 21 7 24 4 320 34.2 9.23 3 6 4 3 5 9 5 5 3297277.625 5628801.313 5702957.938 5036207.375 4 4 4 4 metabolic process;transport cytoplasm;nucleus;spliceosomal complex DNA binding;RNA binding "Pf00076, Pf13893, Pf14259" 15382 ENSMUSG00000046434.15 Hnrnpa1 15 mRNA Splicing - Major Pathway; FGFR2 alternative splicing Spliceosome 0 High Q91ZE0 "Trimethyllysine dioxygenase, mitochondrial OS=Mus musculus OX=10090 GN=Tmlhe PE=1 SV=2" 0 35.833 29 11 24 11 421 49.6 8.25 1 4 2 11 1 5 2 16 524954.4297 5458513.813 3348327.906 31318639.5 2 7 6 10 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;metal ion binding "Pf02668, Pf06155" 192289 ENSMUSG00000079834.2 Tmlhe X Carnitine synthesis Lysine degradation 0 High O54724 Caveolae-associated protein 1 OS=Mus musculus OX=10090 GN=Cavin1 PE=1 SV=1 0 31.57 20 7 24 7 392 43.9 5.52 3 4 4 6 4 6 6 8 4404690.297 7997933.125 8284205.297 8012032.438 6 6 7 7 metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus protein binding;RNA binding Pf15237 19285 ENSMUSG00000004044.9 Ptrf; Cavin1 11 RNA Polymerase I Transcription Termination 0 High P28301 Protein-lysine 6-oxidase OS=Mus musculus OX=10090 GN=Lox PE=1 SV=1 0 40.013 34 10 24 10 411 46.7 8.43 1 3 1 10 1 3 1 19 640661.5859 3576727.25 3024038.711 17637085.63 3 7 7 7 cell organization and biogenesis;metabolic process;response to stimulus extracellular;nucleus catalytic activity;metal ion binding;protein binding Pf01186 16948 ENSMUSG00000024529.13 Lox 18 Elastic fibre formation; Crosslinking of collagen fibrils 0 High P10605 Cathepsin B OS=Mus musculus OX=10090 GN=Ctsb PE=1 SV=2 0 38.442 21 6 24 6 339 37.3 5.91 3 4 6 4 8 12 757215.75 3609312.875 6776357.25 18635949.06 3 4 4 5 cell differentiation;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;extracellular;membrane;mitochondrion;vacuole catalytic activity;protein binding "Pf00112, Pf08127" 13030 ENSMUSG00000021939.7 Ctsb 14 Neutrophil degranulation; Collagen degradation; Trafficking and processing of endosomal TLR NOD-like receptor signaling pathway; Lysosome; Antigen processing and presentation; Renin secretion; Apoptosis 0 High P62281 40S ribosomal protein S11 OS=Mus musculus OX=10090 GN=Rps11 PE=1 SV=3 0 31.606 45 7 24 7 158 18.4 10.3 1 7 5 6 1 9 6 8 4099112.25 17144039.38 17922807.31 21203331.88 5 6 7 6 cell differentiation;metabolic process cytoplasm;membrane;ribosome RNA binding;structural molecule activity Pf00366 27207 ENSMUSG00000003429.11 Rps11 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P63276 40S ribosomal protein S17 OS=Mus musculus OX=10090 GN=Rps17 PE=1 SV=2 0 25.92 49 5 24 5 135 15.5 9.85 3 2 3 4 5 5 6 8 5208291.625 7823436.75 7197142.313 9998105.313 2 2 2 3 cell organization and biogenesis;metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00833 20068 ENSMUSG00000061787.15 Rps17 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P04117 "Fatty acid-binding protein, adipocyte OS=Mus musculus OX=10090 GN=Fabp4 PE=1 SV=3" 0 36.442 47 7 24 7 132 14.6 8.4 4 4 1 7 4 6 1 13 8965060.906 17675177.66 8955197.734 40455710 6 7 6 7 cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus transporter activity Pf00061 11770 ENSMUSG00000062515.3 Fabp4 3 Triglyceride catabolism; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes PPAR signaling pathway; Regulation of lipolysis in adipocytes 0 High Q91ZA3 "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Mus musculus OX=10090 GN=Pcca PE=1 SV=2" 0 48.852 23 13 24 13 724 79.9 7.25 4 4 11 4 4 16 1303415.75 3473904.391 3007750.914 12799558.25 7 9 9 11 extracellular;mitochondrion;organelle lumen catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00289, Pf00364, Pf01071, Pf02222, Pf02258, Pf02785, Pf02786, Pf07478, Pf08442, Pf13533, Pf13535, Pf13549, Pf15632" 110821 ENSMUSG00000041650.15 Pcca 14 Propionyl-CoA catabolism; Biotin transport and metabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High P14131 40S ribosomal protein S16 OS=Mus musculus OX=10090 GN=Rps16 PE=1 SV=4 0 22.644 63 10 24 10 146 16.4 10.21 2 4 6 9 2 4 6 12 4116286.156 12731958.44 11410497.44 18066707.19 10 9 9 10 Met-loss [N-Term] metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00380 100039355; 20055 ENSMUSG00000037563.15 Rps16-ps2; Rps16 5; 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 Medium O54988 STE20-like serine/threonine-protein kinase OS=Mus musculus OX=10090 GN=Slk PE=1 SV=2 0.045 1.075 1 1 23 1 1233 141.4 5.14 1 1 1 1 3 2 8 10 3048169597 2279846940 2462787994 1916959789 1 1 1 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714, Pf12474, Pf14531" 20874 ENSMUSG00000025060.14 Slk 19 Oocyte meiosis 0 High O70325 Phospholipid hydroperoxide glutathione peroxidase OS=Mus musculus OX=10090 GN=Gpx4 PE=1 SV=4 0 16.97 27 5 23 5 197 22.2 8.46 4 5 5 5 4 6 7 6 3601418.75 8974426.75 7165691.813 11454026.75 5 5 5 5 cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding Pf00255 625249 ENSMUSG00000075706.10 Gpx4 10 Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives Glutathione metabolism 0 High Q8VDD5 Myosin-9 OS=Mus musculus OX=10090 GN=Myh9 PE=1 SV=4 0 25.002 5 9 23 8 1960 226.2 5.66 1 7 7 6 1 7 9 6 1652719.613 2159869.891 6262636.93 2130314.602 7 5 8 6 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding;transporter activity "Pf00063, Pf01442, Pf01496, Pf01576, Pf01765, Pf02463, Pf02736, Pf03962, Pf04111, Pf04156, Pf05667, Pf05911, Pf06160, Pf06637, Pf07111, Pf07888, Pf08317, Pf09726, Pf09731, Pf10498, Pf11559, Pf11917, Pf12128, Pf13094, Pf13166" 17886 ENSMUSG00000022443.16 Myh9 15 RHO GTPases activate PAKs Regulation of actin cytoskeleton; Tight junction 1 High I7HLV2 60S ribosomal protein L10 (Fragment) OS=Mus musculus OX=10090 GN=Rpl10 PE=1 SV=1 0 35.843 36 6 23 6 201 23.1 10.01 2 5 3 6 2 7 5 9 2855998.734 14149260.38 9036015.5 18431521.94 4 5 4 6 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;ribosome RNA binding;structural molecule activity Pf00252 110954 ENSMUSG00000008682.13 Rpl10 X 0 High P70302 Stromal interaction molecule 1 OS=Mus musculus OX=10090 GN=Stim1 PE=1 SV=2 0 70.279 30 14 23 10 685 77.5 6.54 14 23 42164.27734 292671.0547 334060.0703 37334559.81 1 2 2 13 cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;endoplasmic reticulum;membrane metal ion binding;protein binding;transporter activity "Pf00430, Pf04111, Pf07647" 20866 ENSMUSG00000030987.5 Stim1 7 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis Platelet activation; Calcium signaling pathway 3 High A2AN08 E3 ubiquitin-protein ligase UBR4 OS=Mus musculus OX=10090 GN=Ubr4 PE=1 SV=1 0 45.231 4 18 23 18 5180 571.9 6.06 1 3 17 1 4 18 1765029.016 3421106.391 3870198.516 11418292.66 3 7 7 13 metabolic process cytoplasm;cytoskeleton;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf02207, Pf13764" 69116 ENSMUSG00000066036.14 Ubr4 4 Neutrophil degranulation Viral carcinogenesis 0 High Q60668 Heterogeneous nuclear ribonucleoprotein D0 OS=Mus musculus OX=10090 GN=Hnrnpd PE=1 SV=2 0 23.525 25 7 23 6 355 38.3 7.81 1 5 6 5 1 7 8 7 2360541.438 20404833.38 18701430.28 20845677.13 3 6 6 6 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 11991 ENSMUSG00000000568.15 Hnrnpd 5 mRNA Splicing - Major Pathway; AUF1 (hnRNP D0) binds and destabilizes mRNA 1 High P31324 cAMP-dependent protein kinase type II-beta regulatory subunit OS=Mus musculus OX=10090 GN=Prkar2b PE=1 SV=3 0 43.794 23 8 23 8 416 46.1 4.98 4 4 4 7 4 4 4 11 3070309.914 4388682.25 3310627.563 16774508.59 6 6 5 8 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane enzyme regulator activity;nucleotide binding;protein binding "Pf00027, Pf02197" 19088 ENSMUSG00000002997.15 Prkar2b 12 PKA activation; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Signaling by GPCR; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; PKA activation in glucagon signalling; DARPP-32 events; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production Insulin signaling pathway 0 High K4DI77 WD repeat-containing protein 81 (Fragment) OS=Mus musculus OX=10090 GN=Wdr81 PE=1 SV=1 0 32.568 9 12 23 12 1934 211.8 5.77 6 6 9 7 7 9 8673701.676 18857231.44 18533051.22 21112390.97 4 10 11 10 cell organization and biogenesis mitochondrion protein binding "Pf00400, Pf02138" ENSMUSG00000045374.18 11 0 High O88322 Nidogen-2 OS=Mus musculus OX=10090 GN=Nid2 PE=1 SV=2 0 29.672 12 12 23 12 1403 153.8 5.38 2 8 8 5 2 8 8 5 1675913.625 7034447.969 4986735.844 7254792.906 6 9 9 10 cell surface;extracellular;membrane metal ion binding;protein binding "Pf00058, Pf00086, Pf06119, Pf06247, Pf07474, Pf07645, Pf08450, Pf12662, Pf12947, Pf14670" 18074 ENSMUSG00000021806.3 Nid2 14 Laminin interactions 0 High E9Q3B1 RCC1 and BTB domain-containing protein 2 OS=Mus musculus OX=10090 GN=Rcbtb2 PE=1 SV=1 0 32.824 20 7 23 6 517 56.3 5.47 4 4 5 6 4 5 8 6 6101287.094 10261979.47 12156593.25 15240682.75 5 5 5 5 protein binding "Pf00415, Pf00651, Pf13540" ENSMUSG00000022106.14 14 1 High P01029 Complement C4-B OS=Mus musculus OX=10090 GN=C4b PE=1 SV=3 0 32.456 7 12 23 12 1738 192.8 7.53 6 5 12 6 5 12 12948915.03 10506977.22 14494594.25 6 6 11 defense response;metabolic process;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 12268 ENSMUSG00000073418.4 C4b 17 Regulation of Complement cascade; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Activation of C3 and C5; Post-translational protein phosphorylation; Initial triggering of complement Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Systemic lupus erythematosus 0 High P54818 Galactocerebrosidase OS=Mus musculus OX=10090 GN=Galc PE=1 SV=2 0 23.859 12 6 22 6 684 77.2 6.74 3 4 4 6 4 5 5 8 8514096.781 12018940.56 14068876.44 16162621.13 5 5 5 5 metabolic process mitochondrion;vacuole catalytic activity Pf02057 14420 ENSMUSG00000021003.9 Galc 12 Glycosphingolipid metabolism Metabolic pathways; Lysosome; Sphingolipid metabolism 0 High Q6ZWZ4 60S ribosomal protein L36 OS=Mus musculus OX=10090 GN=Rpl36 PE=1 SV=1 0 11.777 30 4 22 4 105 12.2 11.59 2 4 4 4 2 7 6 7 4491899.063 15214857.13 12959381.38 17461725.25 4 4 4 4 metabolic process ribosome RNA binding;structural molecule activity Pf01158 54217 ENSMUSG00000057863.5 Rpl36 17 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q91VD9 "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs1 PE=1 SV=2" 0 41.715 19 12 22 12 727 79.7 5.72 2 3 12 2 3 17 245724.4609 3556114.5 3291855.5 18896437.75 2 7 6 11 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding "Pf00111, Pf00384, Pf09326, Pf10588, Pf13510" 227197 ENSMUSG00000025968.16 Ndufs1 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q7TNV0 Protein DEK OS=Mus musculus OX=10090 GN=Dek PE=1 SV=1 0 18.014 14 7 22 7 380 43.1 6.86 5 6 4 6 5 7 4 6 9712358.5 11193809.22 9449071.273 8542334.094 7 7 7 6 cell organization and biogenesis;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf02037, Pf08766" 110052 ENSMUSG00000021377.14 Dek 13 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; B-WICH complex positively regulates rRNA expression 0 High A0A0R4J0D3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Mus musculus OX=10090 GN=Stt3b PE=1 SV=1 0 41.811 17 13 22 11 823 93.3 9 13 22 1479441.563 480796.6797 118990.7109 32979617.88 2 2 1 10 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding "Pf02516, Pf13231" 68292 ENSMUSG00000032437.10 Stt3b 9 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High Q80SY5 Pre-mRNA-splicing factor 38B OS=Mus musculus OX=10090 GN=Prpf38b PE=1 SV=1 0 29.333 21 8 22 8 542 63.7 10.54 6 7 3 4 7 8 3 4 6519088.875 7826676.016 4209587.375 6694433.188 7 9 6 7 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex RNA binding Pf03371 66921 ENSMUSG00000027881.14 Prpf38b 3 Spliceosome 0 High Q9DBG6 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Mus musculus OX=10090 GN=Rpn2 PE=1 SV=1 0 63.687 25 11 22 11 631 69 5.81 1 1 11 2 1 19 580711.7656 1561752.297 1303570.656 34977559.44 2 4 4 10 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf05817 20014 ENSMUSG00000027642.15 Rpn2 2 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High P62270 40S ribosomal protein S18 OS=Mus musculus OX=10090 GN=Rps18 PE=1 SV=3 0 13.181 30 5 22 5 152 17.7 10.99 3 4 3 4 3 7 6 6 3373464.156 9523959.563 6701901.5 11772588.66 5 5 4 5 metabolic process cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00416 20084 ENSMUSG00000008668.14 Rps18 17 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High O55143 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Mus musculus OX=10090 GN=Atp2a2 PE=1 SV=2 0 50.178 16 14 22 10 1044 114.8 5.34 1 1 14 1 1 20 704986.7891 2549197.656 1600832.234 25766363.25 4 7 3 13 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 11938 ENSMUSG00000029467.15 Atp2a2 5 Ion transport by P-type ATPases; Ion homeostasis; Reduction of cytosolic Ca++ levels Hypertrophic cardiomyopathy (HCM); Pancreatic secretion; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Thyroid hormone signaling pathway; cGMP-PKG signaling pathway; Calcium signaling pathway; Alzheimer's disease; Cardiac muscle contraction; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes 4 High D3Z1Y1 E3 ubiquitin-protein ligase synoviolin OS=Mus musculus OX=10090 GN=Syvn1 PE=1 SV=1 0 34.274 16 10 22 10 608 66.9 7.08 3 2 10 3 3 16 672295.3125 9485285.508 10471108.39 52316796.88 1 8 7 10 metabolic process membrane catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" ENSMUSG00000024807.17 19 Hedgehog ligand biogenesis; ER Quality Control Compartment (ERQC) 0 High P61982 14-3-3 protein gamma OS=Mus musculus OX=10090 GN=Ywhag PE=1 SV=2 0 25.92 36 10 22 4 247 28.3 4.89 1 6 6 8 1 6 6 9 844766.3906 28454317.13 26090212.97 33397932.97 2 9 8 10 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;protein binding;RNA binding Pf00244 22628 ENSMUSG00000051391.9 Ywhag 5 Translocation of GLUT4 to the plasma membrane; Anchoring of the basal body to the plasma membrane; Activation of BAD and translocation to mitochondria ; AURKA Activation by TPX2; RHO GTPases activate PKNs; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 6 High Q8CAQ8 MICOS complex subunit Mic60 OS=Mus musculus OX=10090 GN=Immt PE=1 SV=1 0 38.044 16 9 22 5 757 83.8 6.61 1 4 5 8 1 4 5 12 1035024.695 2087906.969 3936782.469 11248518.78 4 5 7 8 cell organization and biogenesis;cellular homeostasis membrane;mitochondrion protein binding;RNA binding Pf09731 76614 ENSMUSG00000052337.15 Immt 6 4 High J3QNW9 Kinesin-like protein KIF7 OS=Mus musculus OX=10090 GN=Kif7 PE=1 SV=1 0 4.143 2 1 22 1 1348 151.6 6.57 1 1 1 1 1 1 9 11 1003470287 1243224376 1193651553 1127270176 2 2 2 2 cellular component movement;regulation of biological process cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf09726" 16576 ENSMUSG00000050382.14 Kif7 7 Hedgehog 'on' state; Hedgehog 'off' state Hedgehog signaling pathway 0 High S4R1X1 WD repeat-containing protein 91 OS=Mus musculus OX=10090 GN=Wdr91 PE=1 SV=1 0 31.883 21 9 21 9 604 67.7 6.67 4 5 8 5 6 10 737840.1406 5405545.906 5790592.531 7402593.484 3 6 6 7 protein binding Pf00400 ENSMUSG00000058486.11 6 0 High E9Q557 Desmoplakin OS=Mus musculus OX=10090 GN=Dsp PE=1 SV=1 0 28.654 4 12 21 12 2883 332.7 6.8 5 6 5 4 5 6 6 4 5779137.141 5923071.5 8182688.039 6148903.984 9 9 9 10 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity "Pf00038, Pf00681, Pf01576, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06637, Pf06705, Pf07888, Pf10174, Pf12128" 109620 ENSMUSG00000054889.9 Dsp 13 Formation of the cornified envelope; Neutrophil degranulation Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0 High Q62351 Transferrin receptor protein 1 OS=Mus musculus OX=10090 GN=Tfrc PE=1 SV=1 0 56.035 21 13 21 13 763 85.7 6.57 1 1 13 1 1 19 2154527.047 4490783.227 4349691.469 37861230.38 4 6 5 12 cell communication;cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;endosome;extracellular;membrane;mitochondrion;nucleus protein binding;receptor activity;RNA binding;transporter activity "Pf02225, Pf04253, Pf04389" 22042 ENSMUSG00000022797.15 Tfrc 16 Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling Endocytosis; Phagosome; HIF-1 signaling pathway; Hematopoietic cell lineage 0 High P62889 60S ribosomal protein L30 OS=Mus musculus OX=10090 GN=Rpl30 PE=1 SV=2 0 36.484 51 4 21 4 115 12.8 9.63 1 3 3 4 1 7 6 7 2734027.281 11696623.13 12842237.25 14386144.5 3 3 4 4 defense response;metabolic process;response to stimulus membrane;nucleus;ribosome RNA binding;structural molecule activity Pf01248 19946; 667779; 666899 ENSMUSG00000058600.13 Rpl30; Rpl30-ps8; Gm12191 15; 12; 11 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q501J6 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus OX=10090 GN=Ddx17 PE=1 SV=1 0 24.654 13 7 21 2 650 72.4 8.59 2 5 6 5 2 6 7 6 618139.4375 496895.5313 624528.125 1 1 1 cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271" 67040 Ddx17 15 0 High Q9CZM2 60S ribosomal protein L15 OS=Mus musculus OX=10090 GN=Rpl15 PE=1 SV=4 0 18.985 35 7 21 7 204 24.1 11.62 7 4 5 8 7 6 2394986.141 13733502.31 9254583 13016850.94 4 7 6 6 metabolic process membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf00827 66480 ENSMUSG00000012405.15 Rpl15 14 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q9R020 Zinc finger Ran-binding domain-containing protein 2 OS=Mus musculus OX=10090 GN=Zranb2 PE=1 SV=2 0 21.255 25 8 21 8 330 37.3 9.89 7 2 3 3 9 3 4 5 15794021.88 11157460.94 12150893.44 11817968.69 7 4 4 4 metabolic process nucleus metal ion binding;RNA binding Pf00641 53861 ENSMUSG00000028180.18 Zranb2 3 0 High P52480 Pyruvate kinase PKM OS=Mus musculus OX=10090 GN=Pkm PE=1 SV=4 0 24.338 19 8 21 8 531 57.8 7.47 4 5 3 7 4 5 3 9 3044815.484 5490850.156 4894238.578 11755534.88 6 6 6 6 cell death;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00224, Pf02887" 18746 ENSMUSG00000032294.17 Pkm 9 Neutrophil degranulation; Glycolysis Pyruvate metabolism; Type II diabetes mellitus; Metabolic pathways; Biosynthesis of amino acids; Purine metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway; Viral carcinogenesis 0 High O70423 Membrane primary amine oxidase OS=Mus musculus OX=10090 GN=Aoc3 PE=1 SV=3 0 42.161 19 10 21 10 765 84.5 6.42 1 10 1 20 2032693.281 404363.2813 561835.3438 22564007.5 3 1 2 9 cellular component movement;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf01179, Pf02727, Pf02728" 11754 ENSMUSG00000019326.14 Aoc3 11 Phase I - Functionalization of compounds "Metabolic pathways; Glycine, serine and threonine metabolism; beta-Alanine metabolism; Phenylalanine metabolism; Tyrosine metabolism" 0 High F8VPM7 ELKS/Rab6-interacting/CAST family member 1 OS=Mus musculus OX=10090 GN=Erc1 PE=1 SV=1 0 21.328 7 7 20 3 1120 128.3 5.91 1 6 6 3 1 8 7 4 418338.9219 5387653.719 5137605.078 4402357.375 2 6 6 6 metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;Golgi;membrane protein binding "Pf04156, Pf05529, Pf05557, Pf05622, Pf09457, Pf09726, Pf10174, Pf12128, Pf13166" 111173 ENSMUSG00000030172.15 Erc1 6 4 High P14873 Microtubule-associated protein 1B OS=Mus musculus OX=10090 GN=Map1b PE=1 SV=2 0 40.327 11 16 20 16 2464 270.1 4.83 16 20 9629166.688 11 cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;membrane protein binding 17755 ENSMUSG00000052727.5 Map1b; Mtap1b 13 0 High P26443 "Glutamate dehydrogenase 1, mitochondrial OS=Mus musculus OX=10090 GN=Glud1 PE=1 SV=1" 0 46.779 21 10 20 10 558 61.3 8 2 3 10 2 3 15 478522.4063 1749402.172 2246165.344 14965518.69 3 5 6 9 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf00208, Pf02812" 14661 ENSMUSG00000021794.15 Glud1 14 Transcriptional activation of mitochondrial biogenesis; Amino acid synthesis and interconversion (transamination) "Metabolic pathways; Nitrogen metabolism; Proximal tubule bicarbonate reclamation; Carbon metabolism; D-Glutamine and D-glutamate metabolism; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis" 0 High Q8CJF9 Protein argonaute-3 OS=Mus musculus OX=10090 GN=Ago3 PE=2 SV=2 0 19.9 10 6 20 2 860 97.2 9.1 3 4 6 4 3 4 8 5 453076.8047 531745.1875 488819.5938 488115.8398 2 1 2 2 Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane protein binding;RNA binding "Pf02170, Pf02171, Pf08699" 214150 ENSMUSG00000028842.15 Ago3; Eif2c3 4 Post-transcriptional silencing by small RNAs 0 High P83093 Stromal interaction molecule 2 OS=Mus musculus OX=10090 GN=Stim2 PE=1 SV=2 0 68.673 21 14 20 13 746 83.9 6.79 14 20 1606518.734 1323180.563 19846410.81 2 3 10 cellular homeostasis;regulation of biological process;transport endoplasmic reticulum;membrane metal ion binding;protein binding;transporter activity "Pf00536, Pf07647, Pf13868" 116873 ENSMUSG00000039156.19 Stim2 5 Calcium signaling pathway 0 High P61979 Heterogeneous nuclear ribonucleoprotein K OS=Mus musculus OX=10090 GN=Hnrnpk PE=1 SV=1 0 19.353 17 7 20 7 463 50.9 5.54 1 7 3 5 1 9 4 6 1901892.75 8151918.531 6132036.531 7734786.219 4 6 6 6 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00013, Pf08067, Pf13014, Pf13083" 15387 ENSMUSG00000021546.17 Hnrnpk 13 mRNA Splicing - Major Pathway Herpes simplex infection; MicroRNAs in cancer; Spliceosome; Viral carcinogenesis 0 High P43275 Histone H1.1 OS=Mus musculus OX=10090 GN=H1-1 PE=1 SV=2 0 22.18 30 5 20 3 213 21.8 10.93 2 5 4 3 2 8 7 3 291296.1836 4862751.125 4327993.063 938883.6875 2 3 3 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process cell surface;chromosome;nucleus DNA binding;protein binding Pf00538 80838 ENSMUSG00000049539.2 Hist1h1a 13 0 High Q921G7 "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Mus musculus OX=10090 GN=Etfdh PE=1 SV=1" 0 33.163 18 9 20 9 616 68 7.58 1 3 2 9 1 4 2 13 1560783.402 5167022.766 2442199.188 21755174.25 7 8 6 9 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf00890, Pf01266, Pf01494, Pf01946, Pf03486, Pf05187, Pf05834, Pf07992, Pf12831, Pf13450, Pf13454, Pf13738" 66841 ENSMUSG00000027809.14 Etfdh 3 Respiratory electron transport 0 High P67778 Prohibitin OS=Mus musculus OX=10090 GN=Phb PE=1 SV=1 0 31.988 35 8 20 8 272 29.8 5.76 1 3 3 8 1 3 4 12 1513528.609 4089707.531 4101658.469 20621959 6 6 6 7 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus DNA binding;protein binding Pf01145 18673 ENSMUSG00000038845.11 Phb 11 RAF activation; Interleukin-20 family signaling; Processing of SMDT1 0 High P35441 Thrombospondin-1 OS=Mus musculus OX=10090 GN=Thbs1 PE=1 SV=1 0 25.624 10 10 20 10 1170 129.6 4.96 5 5 5 7 8 5 5712607 4490974.625 4348438.156 8 7 7 cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endoplasmic reticulum;extracellular metal ion binding;protein binding "Pf00090, Pf00093, Pf02210, Pf02412, Pf05735, Pf12947, Pf14828" 21825 Thbs1 2 0 High Q9D2G2 "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dlst PE=1 SV=1" 0 12.181 9 4 20 4 454 49 8.95 4 3 4 2 8 4 5 3 9733930.375 7157619.813 8444386.875 7745130.625 4 4 4 3 metabolic process membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf00198, Pf00364" 78920 ENSMUSG00000004789.9 Dlst 12 Lysine catabolism; Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation Citrate cycle (TCA cycle); Metabolic pathways; Lysine degradation; Carbon metabolism 0 High A2AFQ2 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Mus musculus OX=10090 GN=Hsd17b10 PE=1 SV=1 0 73.933 61 10 20 10 271 28.4 8.76 2 2 10 2 2 16 529222.7656 1965821.563 2764220.031 20993216.81 2 3 4 8 cell organization and biogenesis;metabolic process endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00106, Pf08659, Pf13561" 15108 ENSMUSG00000025260.10 Hsd17b10 X Branched-chain amino acid catabolism 0 High Q8K3B1 F-box/SPRY domain-containing protein 1 OS=Mus musculus OX=10090 GN=Fbxo45 PE=1 SV=2 0 20.611 33 7 19 7 286 30.6 7.85 7 4 5 8 6 5 342911.6406 20104616.88 15013131.25 17121631.13 2 7 7 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;development;metabolic process;response to stimulus membrane protein binding "Pf00622, Pf00646, Pf12937" 268882 ENSMUSG00000035764.5 Fbxo45 16 0 High A0A0A0MQ68 "Glutaryl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Gcdh PE=1 SV=1" 0 44.206 35 10 19 10 447 49.5 8.72 2 4 9 2 5 12 1258695.266 4415539.156 4760484.906 37062502.69 4 5 6 9 metabolic process membrane;mitochondrion catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 270076 ENSMUSG00000003809.14 Gcdh 8 Tryptophan metabolism; Metabolic pathways; Lysine degradation; Fatty acid degradation 0 High P21126 Ubiquitin-like protein 4A OS=Mus musculus OX=10090 GN=Ubl4a PE=1 SV=1 0 23.803 48 7 19 7 157 17.8 8.44 4 5 5 5 7 7 15097969.88 16017350.5 15880623.38 6 6 5 transport cytoplasm;cytosol;membrane;nucleus protein binding "Pf00240, Pf11976" 27643; 100169864 ENSMUSG00000015290.15 Ubl4; Ubl4a; Slc10a3-ubl4; Gm38419; SlcUbl4a; Gm44504 X 0 High P48678 Prelamin-A/C OS=Mus musculus OX=10090 GN=Lmna PE=1 SV=2 0 22.165 18 10 19 10 665 74.2 6.98 7 9 7 12 2141066.211 6399886.063 8150576.938 2202937.797 7 9 9 5 cell organization and biogenesis;regulation of biological process;response to stimulus;transport membrane;nucleus protein binding;structural molecule activity "Pf00038, Pf00932, Pf12128" 16905 ENSMUSG00000028063.15 Lmna 3 Clearance of Nuclear Envelope Membranes from Chromatin; Breakdown of the nuclear lamina; Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Apoptosis 0 High Q9CQV8 14-3-3 protein beta/alpha OS=Mus musculus OX=10090 GN=Ywhab PE=1 SV=3 0 21.837 26 7 19 2 246 28.1 4.83 1 4 5 7 1 5 6 7 76537.59375 1698527.625 1657473.875 2224930.375 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding Pf00244 54401 ENSMUSG00000018326.9 Ywhab 2 Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Rap1 signalling; RAF activation; Interleukin-20 family signaling; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; MAP2K and MAPK activation; Negative regulation of MAPK pathway; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by Hippo Epstein-Barr virus infection; Hippo signaling pathway; Hepatitis B; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High E9PV04 Eukaryotic translation initiation factor 4A3-like 1 OS=Mus musculus OX=10090 GN=Eif4a3l1 PE=3 SV=2 0 22.076 21 8 19 6 411 46.8 7.43 6 8 3 8 8 3 1236208.949 10712995.75 10433207.69 7813288.969 6 8 8 7 metabolic process;regulation of biological process cytoplasm;spliceosomal complex catalytic activity;DNA binding;nucleotide binding "Pf00270, Pf00271, Pf04851" 668137 ENSMUSG00000094973.2 Gm8994 6 mRNA surveillance pathway; Spliceosome; RNA transport 2 High Q9D0M3 "Cytochrome c1, heme protein, mitochondrial OS=Mus musculus OX=10090 GN=Cyc1 PE=1 SV=1" 0 39.082 42 8 19 8 325 35.3 9.16 3 3 8 3 3 13 706034.3828 3001356.453 2571914.195 23035154.13 3 5 4 6 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus metal ion binding;protein binding Pf02167 66445 ENSMUSG00000022551.7 Cyc1 15 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High P08249 "Malate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Mdh2 PE=1 SV=3" 0 35.682 33 10 19 10 338 35.6 8.68 3 4 1 9 3 4 1 11 4277595.297 5779499.063 2472286.031 23675911.38 8 8 6 10 metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00056, Pf01073, Pf01118, Pf02866, Pf13460" 17448 ENSMUSG00000019179.10 Mdh2 5 Gluconeogenesis; Citric acid cycle (TCA cycle) Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Cysteine and methionine metabolism; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High P41105 60S ribosomal protein L28 OS=Mus musculus OX=10090 GN=Rpl28 PE=1 SV=2 0 14.445 30 4 19 4 137 15.7 12.02 3 3 4 4 3 6 6 4 3721029.738 14098131.5 11109045.89 15651637.25 5 5 5 4 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process membrane;ribosome RNA binding;structural molecule activity Pf01778 19943 ENSMUSG00000030432.12 Rpl28 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A0A0G2JF33 Protein FAM133B OS=Mus musculus OX=10090 GN=Fam133b PE=1 SV=1 0 9.821 50 4 19 4 109 13 10.42 2 4 4 2 3 8 5 3 9250414.359 30391172.56 23800953.06 17947409.09 4 4 4 4 ENSMUSG00000058503.11 5 0 High B1AQ75 "Keratin, type I cuticular Ha6 OS=Mus musculus OX=10090 GN=Krt36 PE=1 SV=1" 0 10.097 12 5 19 3 473 52.8 5.05 1 5 1 1 3 8 4 4 893426.5 346588.375 1 1 regulation of biological process cytoskeleton catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf12128, Pf13514" 16673 ENSMUSG00000020916.8 Krt36 11 Formation of the cornified envelope 0 High Q8BWD8 Cyclin-dependent kinase 19 OS=Mus musculus OX=10090 GN=Cdk19 PE=2 SV=1 0 9.844 7 4 19 4 501 56.5 8.53 3 3 4 4 4 4 5 6 1095591.063 3586181.938 2844904.75 4295419.938 3 4 4 4 cell division;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 78334 ENSMUSG00000038481.13 Cdk19 10 0 High Q9Z2I8 "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Suclg2 PE=1 SV=3" 0 47.405 25 10 19 10 433 46.8 7.02 2 2 10 2 3 14 3006057.344 2913663.75 26376632.38 5 5 8 metabolic process membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00549, Pf01071, Pf08442, Pf13549" 20917 ENSMUSG00000061838.7 Suclg2 6 Citric acid cycle (TCA cycle) Citrate cycle (TCA cycle); Metabolic pathways; Propanoate metabolism; Carbon metabolism 0 High O08528 Hexokinase-2 OS=Mus musculus OX=10090 GN=Hk2 PE=1 SV=1 0 39.843 17 13 19 10 917 102.5 6.11 3 2 10 3 2 14 481167.7031 2869205.797 2673996.727 20294184.72 4 7 6 13 Acetyl [N-Term] cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00349, Pf03727" 15277 ENSMUSG00000000628.10 Hk2 6 Glycolysis "Neomycin, kanamycin and gentamicin biosynthesis; Type II diabetes mellitus; Carbohydrate digestion and absorption; Insulin signaling pathway; Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Starch and sucrose metabolism; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Central carbon metabolism in cancer" 3 High G3UZI2 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus OX=10090 GN=Syncrip PE=1 SV=1 0 20.069 14 7 19 7 527 58.7 7.56 7 4 4 9 5 5 1670664.859 7575828.563 7977886.406 7128793.5 5 7 7 7 RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000032423.12 9 0 High Q922B2 "Aspartate--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Dars1 PE=1 SV=2" 0 34.799 24 12 19 12 501 57.1 6.49 1 3 4 10 1 3 4 11 758976.125 3902830.391 3121434.297 13643305.31 4 9 8 11 metabolic process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;RNA binding "Pf00152, Pf01336" 226414 ENSMUSG00000026356.15 Dars 1 Aminoacyl-tRNA biosynthesis 0 High Q3URQ4 "Family with sequence similarity 8, member A1 OS=Mus musculus OX=10090 GN=Fam8a1 PE=1 SV=1" 0 19.422 22 4 19 4 399 42.3 6.71 4 4 4 6 7 6 185435.5938 3180294.844 3937311.375 2667954.938 1 4 4 3 membrane Pf06271 97863 ENSMUSG00000069237.8 C78339; Fam8a1 13 0 High Q8K297 Procollagen galactosyltransferase 1 OS=Mus musculus OX=10090 GN=Colgalt1 PE=1 SV=2 0 61.92 29 14 19 14 617 71 7.28 1 14 1 18 347775.9531 2830770.609 2537776.984 54552343.75 2 6 5 13 endoplasmic reticulum;membrane;organelle lumen catalytic activity Pf01755 234407 ENSMUSG00000034807.9 Glt25d1; Colgalt1 8 Collagen biosynthesis and modifying enzymes Lysine degradation; Other types of O-glycan biosynthesis 0 High P16045 Galectin-1 OS=Mus musculus OX=10090 GN=Lgals1 PE=1 SV=3 0 10.955 26 3 19 3 135 14.9 5.49 2 3 2 3 4 5 4 6 1810588.813 3774262.125 2081067.813 7234799.5 2 3 2 4 cell death;cell differentiation;cellular homeostasis;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;nucleus protein binding;RNA binding;signal transducer activity Pf00337 16852 ENSMUSG00000068220.5 Lgals1 15 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation 0 High A0A1D5RLW5 60S ribosomal protein L18a OS=Mus musculus OX=10090 GN=Rpl18a PE=1 SV=1 0 17.168 49 7 18 7 147 17.4 10.89 2 5 5 4 2 6 5 5 9266340.781 21501233.38 20190019.97 23029023.61 5 7 7 7 metabolic process ribosome structural molecule activity Pf01775 ENSMUSG00000045128.9 8 0 High Q6IME9 "Keratin, type II cytoskeletal 72 OS=Mus musculus OX=10090 GN=Krt72 PE=3 SV=1" 0 13.48 7 5 18 1 520 56.7 7.4 2 3 4 4 4 5 4 5 693665.3125 410714.9375 1299611.25 1 1 1 catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf09728, Pf12128, Pf13514" 105866 ENSMUSG00000056605.6 Krt72; Krt72-ps 15 Formation of the cornified envelope 0 High P20918 Plasminogen OS=Mus musculus OX=10090 GN=Plg PE=1 SV=3 0 4.935 2 2 18 2 812 90.7 6.6 2 2 2 2 4 5 4 5 12262804.5 8524380 10257988.75 6437853.5 2 2 2 2 cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;coagulation;metabolic process;regulation of biological process cell surface;extracellular;membrane catalytic activity;protein binding "Pf00024, Pf00051, Pf00089, Pf09342, Pf13365" 18815 ENSMUSG00000059481.4 Plg 17 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); LDL remodeling; Plasma lipoprotein remodeling; Dissolution of Fibrin Clot; Platelet degranulation ; Signaling by PDGF; Activation of Matrix Metalloproteinases Staphylococcus aureus infection; Complement and coagulation cascades; Influenza A; Neuroactive ligand-receptor interaction 0 High Q80XR6 Heterogeneous nuclear ribonucleoprotein A/B OS=Mus musculus OX=10090 GN=Hnrnpab PE=1 SV=1 0 20.01 22 6 18 5 311 33.8 5.83 1 5 4 3 1 7 5 5 1505542.313 5274633.063 3616724.781 3596765 3 4 3 2 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08143, Pf13893, Pf14259" 15384 ENSMUSG00000020358.17 Hnrnpab 11 0 High F6SH71 BTB/POZ domain-containing protein KCTD2 (Fragment) OS=Mus musculus OX=10090 GN=Kctd2 PE=1 SV=1 0 32.146 24 4 18 4 278 30.1 5.29 3 4 4 5 7 6 7723871 16203644.63 15064344.38 17714497.03 1 4 4 6 cell organization and biogenesis protein binding Pf02214 ENSMUSG00000016940.18 11 0 High V9GXX7 DNA repair protein SWI5 homolog (Fragment) OS=Mus musculus OX=10090 GN=Swi5 PE=1 SV=1 0 31.846 34 5 18 5 140 16.1 6.02 4 3 3 6 6 6 3649874.563 3888815.938 3475987.5 3 3 2 metabolic process "Pf04111, Pf07061" ENSMUSG00000044627.11 2 0 High Q91VT4 Carbonyl reductase family member 4 OS=Mus musculus OX=10090 GN=Cbr4 PE=1 SV=2 0 45.225 52 9 18 9 236 25.4 9.69 1 1 9 1 1 16 443614.2656 2576654.969 3123066.75 49178311.86 2 4 3 9 cell organization and biogenesis;metabolic process mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00106, Pf03435, Pf08659, Pf13561" 234309 ENSMUSG00000031641.14 Cbr4 8 Fatty acyl-CoA biosynthesis 0 High O55142 60S ribosomal protein L35a OS=Mus musculus OX=10090 GN=Rpl35a PE=1 SV=2 0 11.021 53 7 18 7 110 12.5 10.89 2 5 4 6 2 5 4 7 4724793.469 15808935.13 11112798.13 18264184.88 6 7 5 6 metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity Pf01247 100043423; 57808; 100042363; 100302576; 100040169; 100046034; 100048620 ENSMUSG00000060636.13 Rpl35a-ps4; Rpl35a; Rpl35a-ps2; Gm10243; Rpl35a-ps5; LOC100862595; Gm14279; LOC100048620 2; 16; 1; 6; 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 Medium Q6P5H2 Nestin OS=Mus musculus OX=10090 GN=Nes PE=1 SV=1 0.022 1.457 0 1 18 1 1864 207 4.34 1 1 1 1 4 4 5 5 77992063.25 108207512 122036584 92635792 1 1 1 1 cell organization and biogenesis;cell proliferation;development;regulation of biological process cytoplasm;cytoskeleton protein binding;structural molecule activity "Pf00038, Pf02463" 18008 ENSMUSG00000004891.16 Nes 3 0 High Q8VDP4 Cell cycle and apoptosis regulator protein 2 OS=Mus musculus OX=10090 GN=Ccar2 PE=1 SV=2 0 24.725 12 7 18 7 922 102.9 5.25 4 3 7 5 4 9 259609.6172 2306013.938 1924109.516 5782626.906 2 4 4 6 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;organelle lumen;spliceosomal complex enzyme regulator activity;protein binding;RNA binding "Pf14443, Pf14444" 219158 ENSMUSG00000033712.5 2610301G19Rik; Ccar2 14 Regulation of HSF1-mediated heat shock response 0 High Q6ZWU9 40S ribosomal protein S27 OS=Mus musculus OX=10090 GN=Rps27 PE=1 SV=3 0 20.296 39 4 18 1 84 9.5 9.45 1 2 2 4 1 3 3 11 525921.0313 1429824.438 1245734.313 5801907.656 1 1 1 1 cell organization and biogenesis;metabolic process ribosome metal ion binding;protein binding;structural molecule activity Pf01667 57294; 100043813 ENSMUSG00000090733.6; ENSMUSG00000050621.7 Rps27; Gm9846; Rps27rt 3; 9 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Formation of a pool of free 40S subunits; Translation initiation complex formation; L13a-mediated translational silencing of Ceruloplasmin expression; Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; Ribosomal scanning and start codon recognition; RHO GTPases Activate Formins; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex" Ribosome 0 High Q9WTZ2 Membrane-bound transcription factor site-1 protease OS=Mus musculus OX=10090 GN=Mbtps1 PE=1 SV=1 0 52.425 16 14 18 14 1052 117.4 8.76 14 18 17926713.86 13 cell organization and biogenesis;metabolic process;regulation of biological process endoplasmic reticulum;Golgi;membrane;organelle lumen catalytic activity "Pf00082, Pf14258" 56453 ENSMUSG00000031835.16 Mbtps1 8 CREB3 factors activate genes; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Regulation of cholesterol biosynthesis by SREBP (SREBF); ATF6 (ATF6-alpha) activates chaperones Protein processing in endoplasmic reticulum 0 High P54071 "Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus OX=10090 GN=Idh2 PE=1 SV=3" 0 33.394 23 9 18 9 452 50.9 8.69 2 4 3 8 2 5 3 8 2750015.281 4952258.859 4195518.688 10152078.56 6 8 8 9 metabolic process;regulation of biological process cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00180 269951 ENSMUSG00000030541.16 Idh2 7 Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle) Glutathione metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Peroxisome 0 High Q8C0C7 Phenylalanine--tRNA ligase alpha subunit OS=Mus musculus OX=10090 GN=Farsa PE=1 SV=1 0 34.275 24 11 18 11 508 57.6 8.28 1 2 11 1 2 15 410658.1484 958317.6563 859885.2266 12757476.91 4 5 5 10 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;membrane catalytic activity;nucleotide binding;RNA binding "Pf00152, Pf01409, Pf08279" 66590 ENSMUSG00000003808.18 Farsa 8 Aminoacyl-tRNA biosynthesis 0 High Q9D1R9 60S ribosomal protein L34 OS=Mus musculus OX=10090 GN=Rpl34 PE=1 SV=2 0 8.637 29 5 18 5 117 13.3 11.47 3 5 2 4 4 6 3 5 5071406.188 22081167.75 13688786.06 20443026.75 4 5 4 5 metabolic process mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf01199 619547; 68436; 100043876 ENSMUSG00000062006.12 Rpl34-ps1; Rpl34; Gm4705 6; 3; 17 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P49718 DNA replication licensing factor MCM5 OS=Mus musculus OX=10090 GN=Mcm5 PE=1 SV=2 0 42.479 23 13 18 13 734 82.4 8.29 1 1 13 1 1 16 2503522.578 4749408.625 5226695.563 15148140 3 7 7 10 0 High Q4FK66 Pre-mRNA-splicing factor 38A OS=Mus musculus OX=10090 GN=Prpf38a PE=1 SV=1 0 19.118 21 6 18 6 312 37.4 10.01 3 5 4 4 4 5 4 5 7991138.063 8332512.875 6663273.313 5721574.688 6 6 6 5 metabolic process membrane;nucleus;spliceosomal complex RNA binding Pf03371 230596 ENSMUSG00000063800.5 Prpf38a 4 mRNA Splicing - Major Pathway Spliceosome 0 High P97762 Retinitis pigmentosa 9 protein homolog OS=Mus musculus OX=10090 GN=rp9 PE=1 SV=1 0 6.732 11 2 17 2 213 25.2 9.83 2 2 2 2 4 5 5 3 3188130.031 4237927.063 5883636.125 3210688.406 2 2 2 2 metabolic process cytosol;nucleus metal ion binding;protein binding;RNA binding 55934 ENSMUSG00000032239.10 Rp9 9 Spliceosome 0 High Q925I1 ATPase family AAA domain-containing protein 3 OS=Mus musculus OX=10090 GN=Atad3 PE=1 SV=1 0 42.089 26 13 17 13 591 66.7 9.29 1 13 1 16 513505.1133 797193.6563 1090857.059 19964944.25 4 3 4 11 Met-loss+Acetyl [N-Term] cell growth;regulation of biological process membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401" 108888 ENSMUSG00000029036.18 Atad3a 4 Neutrophil degranulation 0 High Q8BMF4 "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dlat PE=1 SV=2" 0 21.921 12 6 17 6 642 67.9 8.57 4 2 1 3 8 3 2 4 6602990.344 3980745 4154392 7375630.984 4 4 4 5 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 235339 ENSMUSG00000000168.9 Dlat 9 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; Carbon metabolism 0 High D3Z712 40S ribosomal protein S15a (Fragment) OS=Mus musculus OX=10090 GN=Rps15a PE=1 SV=2 0 12.531 58 5 17 5 78 8.8 10.43 2 4 2 4 3 5 3 6 2835727.797 11562582.88 9565294.625 20885877.75 4 5 5 5 metabolic process mitochondrion;ribosome structural molecule activity Pf00410 ENSMUSG00000008683.16 7 0 High Q8K2I9 F-box DNA helicase 1 OS=Mus musculus OX=10090 GN=Fbh1 PE=1 SV=1 0 18.201 6 7 17 7 1042 118.2 8.13 4 2 5 6 5 6 4142729.328 3613060.406 5016612 7 6 6 cell death;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00580, Pf00646, Pf12937, Pf13086, Pf13361, Pf13538" 50755 ENSMUSG00000058594.15 Fbxo18 2 0 High P18242 Cathepsin D OS=Mus musculus OX=10090 GN=Ctsd PE=1 SV=1 0 23.281 17 5 17 5 410 44.9 7.15 2 3 5 2 5 10 816933.75 3628078.234 6223353.063 9358293.281 2 4 4 4 cell organization and biogenesis;metabolic process extracellular;membrane;mitochondrion;vacuole catalytic activity "Pf00026, Pf07966, Pf14541, Pf14543" 13033 ENSMUSG00000007891.16 Ctsd 7 MHC class II antigen presentation; Neutrophil degranulation; Collagen degradation Tuberculosis; Lysosome; Sphingolipid signaling pathway; Apoptosis 0 High P27773 Protein disulfide-isomerase A3 OS=Mus musculus OX=10090 GN=Pdia3 PE=1 SV=2 0 34.672 28 11 17 11 505 56.6 6.21 1 2 11 1 2 14 1368820.359 2750197.172 1341640.984 14362453.88 5 6 3 9 cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endoplasmic reticulum;extracellular;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding;RNA binding "Pf00085, Pf13098, Pf13848, Pf13899, Pf13905" 14827 ENSMUSG00000027248.13 Pdia3 2 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle; ER-Phagosome pathway" Antigen processing and presentation; Protein processing in endoplasmic reticulum 0 High Q61033 "Lamina-associated polypeptide 2, isoforms alpha/zeta OS=Mus musculus OX=10090 GN=Tmpo PE=1 SV=4" 0 23.662 20 10 17 10 693 75.1 8.05 6 9 1 7 9 1 2034498.984 10513406.75 19961599.31 1892049.141 6 9 10 5 regulation of biological process chromosome;membrane;nucleus DNA binding;protein binding "Pf03020, Pf08198, Pf11560" 21917 ENSMUSG00000019961.17 Tmpo 10 0 High A0A087WS16 "Collagen, type VI, alpha 3 OS=Mus musculus OX=10090 GN=Col6a3 PE=1 SV=1" 0 44.087 7 14 17 14 2677 288.5 8.53 2 2 13 2 2 13 2401888.811 4389201.391 4302481.672 7836568.484 6 11 8 13 regulation of biological process extracellular;membrane enzyme regulator activity;protein binding "Pf00014, Pf00041, Pf00092, Pf01391, Pf13519, Pf13768" ENSMUSG00000048126.16 1 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures 0 High Q04857 Collagen alpha-1(VI) chain OS=Mus musculus OX=10090 GN=Col6a1 PE=1 SV=1 0 31.39 9 9 17 9 1025 108.4 5.36 4 2 9 4 2 11 332938.3125 3704837.938 3807545.063 12130697.94 2 7 7 8 cell differentiation;cell organization and biogenesis;response to stimulus extracellular;membrane protein binding "Pf00092, Pf01391, Pf13519, Pf13768" 12833 ENSMUSG00000001119.7 Col6a1 10 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures Focal adhesion; Protein digestion and absorption; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q3TEX6 Fanconi anemia group B protein homolog OS=Mus musculus OX=10090 GN=Fancb PE=1 SV=1 0 21.848 10 8 17 8 853 96.9 5.96 5 4 4 6 6 5 4756244.594 4741049.875 4858521.156 6 6 6 metabolic process;regulation of biological process;response to stimulus nucleus 237211 ENSMUSG00000047757.16 Fancb X Fanconi Anemia Pathway Fanconi anemia pathway 0 High A2AL85 Aspartyl/asparaginyl beta-hydroxylase OS=Mus musculus OX=10090 GN=Asph PE=1 SV=1 0 53.116 26 15 17 15 725 81.4 5.11 15 17 359697.2656 2131195.523 1900859.641 15178810.38 2 5 4 12 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding "Pf05118, Pf05279, Pf13414, Pf13428, Pf13432, Pf14559" 65973 ENSMUSG00000028207.18 Asph 4 0 High Q8C3V4 Signal transducer and activator of transcription OS=Mus musculus OX=10090 GN=Stat1 PE=1 SV=1 0 47.474 19 11 17 11 749 87.3 5.71 2 3 11 2 3 12 846894.0156 1637953.109 8675256 3 5 7 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;signal transducer activity "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162" 20846 ENSMUSG00000026104.14 Stat1 1 Signaling by SCF-KIT; Interleukin-35 Signalling; Regulation of IFNG signaling; ISG15 antiviral mechanism; Interleukin-6 family signaling; Downstream signal transduction; Interleukin-4 and 13 signaling; Regulation of IFNA signaling 0 High B1AU25 "Apoptosis-inducing factor 1, mitochondrial OS=Mus musculus OX=10090 GN=Aifm1 PE=1 SV=1" 0 53.056 27 12 17 12 608 66.1 9.11 2 1 11 3 1 13 2743914.406 1179778.375 1427422.766 25808093.63 5 1 2 10 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00070, Pf07992, Pf14721, Pf14962" 26926 ENSMUSG00000036932.14 Aifm1 X 0 High Q9ESU6 Bromodomain-containing protein 4 OS=Mus musculus OX=10090 GN=Brd4 PE=1 SV=2 0 16.014 4 5 17 1 1400 155.8 9.19 3 5 3 2 4 6 4 3 441027.8125 927749.5625 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process chromosome;nucleus catalytic activity;DNA binding;protein binding Pf00439 57261 ENSMUSG00000024002.16 Brd4 17 0 High Q61765 "Keratin, type I cuticular Ha1 OS=Mus musculus OX=10090 GN=Krt31 PE=1 SV=2" 0 2.538 4 2 16 1 416 47.1 4.89 1 2 1 1 3 5 4 4 308219.25 307557.75 1 1 catalytic activity;motor activity;structural molecule activity "Pf00038, Pf01576, Pf13514" 16660 ENSMUSG00000048981.1 Krt31 11 Formation of the cornified envelope 0 High Q91Y06 Protocadherin beta 13 OS=Mus musculus OX=10090 GN=Pcdhb13 PE=2 SV=1 0 2.649 3 1 16 1 796 87.5 4.86 1 1 1 3 4 9 1479727841 89430085.5 1717338061 1711380657 2 2 2 2 cell communication;cell organization and biogenesis membrane metal ion binding "Pf00028, Pf08266" 93884 ENSMUSG00000047307.2 Pcdhb13 18 0 High Q3TWW8 Serine/arginine-rich splicing factor 6 OS=Mus musculus OX=10090 GN=Srsf6 PE=1 SV=1 0 15.826 19 7 16 5 339 39 11.46 2 5 5 3 2 6 5 3 9134640.625 19213414.08 16547408.06 9523147.527 7 7 6 5 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 67996 ENSMUSG00000016921.14 Srsf6 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 2 High P11679 "Keratin, type II cytoskeletal 8 OS=Mus musculus OX=10090 GN=Krt8 PE=1 SV=4" 0 13.608 5 6 16 1 490 54.5 5.82 2 3 4 4 3 4 4 5 cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf01576, Pf04111, Pf09726, Pf10186, Pf12128, Pf13166, Pf13514, Pf15003" 16691 ENSMUSG00000049382.9 Krt8 15 Formation of the cornified envelope 0 High Q8CC88 von Willebrand factor A domain-containing protein 8 OS=Mus musculus OX=10090 GN=Vwa8 PE=1 SV=2 0 46.219 9 13 16 13 1905 213.3 6.6 13 16 557735.8984 1205654.32 1251213.484 12465817.66 4 5 4 14 extracellular;mitochondrion catalytic activity;nucleotide binding "Pf00092, Pf07728, Pf13191, Pf13519, Pf13521" 219189 ENSMUSG00000058997.7 Vwa8 14 0 High Q9D136 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Mus musculus OX=10090 GN=Ogfod3 PE=2 SV=1 0 32.77 22 5 16 5 315 35.4 6.74 2 2 5 2 3 11 1320575.375 4995779.313 6275668.188 26779952.84 2 4 4 5 metabolic process membrane catalytic activity;metal ion binding Pf13640 66179 ENSMUSG00000025169.6 1110031I02Rik; Ogfod3 11 0 High Q02788 Collagen alpha-2(VI) chain OS=Mus musculus OX=10090 GN=Col6a2 PE=1 SV=3 0 20.746 7 6 16 6 1034 110.3 6.42 1 4 4 4 1 5 5 5 450802.6875 3165606.672 3229704.516 5519912.875 4 6 6 5 cell organization and biogenesis;response to stimulus extracellular;membrane "Pf00092, Pf01391, Pf13519" 12834 ENSMUSG00000020241.13 Col6a2 10 ECM proteoglycans; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures Focal adhesion; Protein digestion and absorption; ECM-receptor interaction; PI3K-Akt signaling pathway 0 High Q9CR62 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Mus musculus OX=10090 GN=Slc25a11 PE=1 SV=3 0 31.009 31 9 16 9 314 34.1 9.94 1 2 8 1 2 13 294154.1641 1356741.656 2242642.797 21833552.44 2 3 5 8 transport membrane;mitochondrion;nucleus RNA binding;transporter activity Pf00153 67863 ENSMUSG00000014606.14 Slc25a11 11 Gluconeogenesis 0 High A0A0R3P9C8 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Mus musculus OX=10090 GN=Ndufa9 PE=1 SV=1" 0 71.39 44 13 16 13 373 42.1 9.09 13 16 243280.5781 613860.375 1414856.656 20549921.06 1 1 3 9 metabolic process membrane;mitochondrion catalytic activity "Pf01073, Pf01370, Pf05368, Pf13460" ENSMUSG00000000399.10 6 0 High Q497I4 "Keratin, type I cuticular Ha5 OS=Mus musculus OX=10090 GN=Krt35 PE=1 SV=1" 0 2.621 3 2 16 1 455 50.5 4.97 2 1 1 1 4 4 4 4 631702.75 819882.25 1 1 structural molecule activity Pf00038 53617 ENSMUSG00000048013.9 Krt35 11 Formation of the cornified envelope 0 High Q8CGC7 Bifunctional glutamate/proline--tRNA ligase OS=Mus musculus OX=10090 GN=Eprs1 PE=1 SV=4 0 38.872 11 11 16 11 1512 170 7.66 2 3 10 2 3 11 512773.3047 2912673.164 3244195.75 10265655.22 3 6 8 8 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497" 107508 ENSMUSG00000026615.14 Eprs 1 Metabolic pathways; Aminoacyl-tRNA biosynthesis; Porphyrin and chlorophyll metabolism 0 High Q5SUT0 RNA-binding protein EWS OS=Mus musculus OX=10090 GN=Ewsr1 PE=1 SV=1 0 17.382 11 4 16 4 618 64.9 9.38 3 2 4 3 4 3 5 4 6243474.5 6982978.25 7282583.25 5577710.813 4 4 4 4 metabolic process;regulation of biological process cytoplasm;membrane;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf00641, Pf14259" 14030 ENSMUSG00000009079.16 Ewsr1 11 0 High O35857 Mitochondrial import inner membrane translocase subunit TIM44 OS=Mus musculus OX=10090 GN=Timm44 PE=1 SV=2 0 35.186 24 10 16 10 452 51.1 8.13 2 2 2 8 2 3 2 9 1568098.672 3436070.156 4076653.234 10183203.09 5 6 8 8 transport membrane;mitochondrion;organelle lumen nucleotide binding;protein binding Pf04280 21856 ENSMUSG00000002949.15 Timm44 8 0 High Q99LF4 RNA-splicing ligase RtcB homolog OS=Mus musculus OX=10090 GN=Rtcb PE=1 SV=1 0 17.461 12 5 16 5 505 55.2 7.23 3 4 4 5 3 4 4 5 2151203.109 2863435.563 2943591.125 5058564.75 5 5 5 5 metabolic process cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding Pf01139 28088 ENSMUSG00000001783.3 D10Wsu52e; Rtcb 10 0 High O35206 Collagen alpha-1(XV) chain OS=Mus musculus OX=10090 GN=Col15a1 PE=1 SV=2 0 28.215 7 8 16 8 1367 140.4 4.89 1 7 2 3 1 9 3 3 1391628.313 7331149.781 5505675.141 5561381.828 4 6 6 6 extracellular structural molecule activity "Pf01391, Pf06482, Pf13385" 12819 ENSMUSG00000028339.17 Col15a1 4 Collagen chain trimerization; Collagen degradation Protein digestion and absorption 0 High P00329 Alcohol dehydrogenase 1 OS=Mus musculus OX=10090 GN=Adh1 PE=1 SV=2 0 19.077 16 5 16 5 375 39.7 8.1 1 4 4 5 1 4 4 7 497762.0547 2225136.375 2405257.969 11010185.38 3 4 4 5 metabolic process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00107, Pf08240" 11522 ENSMUSG00000074207.10 Adh1 3 RA biosynthesis pathway; Ethanol oxidation; Abacavir metabolism Drug metabolism - cytochrome P450; Retinol metabolism; Metabolic pathways; Fatty acid degradation; Glycolysis / Gluconeogenesis; Chemical carcinogenesis; Tyrosine metabolism; Metabolism of xenobiotics by cytochrome P450 0 High Q8QZT1 "Acetyl-CoA acetyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Acat1 PE=1 SV=1" 0 33.97 26 9 16 9 424 44.8 8.51 1 4 2 9 1 4 2 9 4660983.078 7586941.266 6534792.406 13951127.53 6 7 7 8 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00108, Pf00109, Pf02803" 110446 ENSMUSG00000032047.5 Acat1 9 Synthesis of Ketone Bodies; Utilization of Ketone Bodies; Branched-chain amino acid catabolism "Fatty acid metabolism; Pyruvate metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Terpenoid backbone biosynthesis; Lysine degradation; Fatty acid degradation; Butanoate metabolism; Propanoate metabolism; Synthesis and degradation of ketone bodies; Carbon metabolism; Glyoxylate and dicarboxylate metabolism" 0 High E9QM38 Solute carrier family 12 member 2 OS=Mus musculus OX=10090 GN=Slc12a2 PE=1 SV=1 0 33.975 7 6 16 6 1206 130.6 6.52 4 3 6 5 3 8 183145.6641 7944776.219 3810075.5 8816444.375 1 6 6 6 cellular homeostasis;regulation of biological process;response to stimulus;transport membrane catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00324, Pf08403, Pf13520" 20496 ENSMUSG00000024597.10 Slc12a2 18 Cation-coupled Chloride cotransporters Pancreatic secretion; Salivary secretion 0 High A2ABV5 Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 0 33.107 9 9 16 9 1459 160.9 8.53 1 2 4 6 1 3 6 6 1069647.051 4365599.672 4606779.641 6674875.531 5 5 6 6 metabolic process;regulation of biological process;response to stimulus membrane;nucleus receptor activity "Pf08638, Pf15449" 26896 ENSMUSG00000064127.13 Med14 X Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway 0 High A6ZI44 Fructose-bisphosphate aldolase OS=Mus musculus OX=10090 GN=Aldoa PE=1 SV=1 0 27.753 25 8 16 8 418 45.1 7.91 3 2 8 3 2 11 2181214.688 4259753.031 2116672.281 9547950.75 4 5 3 6 cellular homeostasis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding Pf00274 11674 ENSMUSG00000030695.14 Aldoa 7 0 High Q6P5E4 UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4 0 36.072 8 11 16 11 1551 176.3 5.62 2 1 11 2 1 13 3549662.648 4810769.281 1643840.336 14795384.06 3 7 5 10 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;organelle lumen catalytic activity;protein binding Pf06427 320011 ENSMUSG00000037470.14 Uggt1 1 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High Q61191 Host cell factor 1 OS=Mus musculus OX=10090 GN=Hcfc1 PE=1 SV=2 0 17.582 4 7 16 7 2045 210.3 7.18 3 3 7 4 3 9 126214.1719 1730281.977 1538141.07 6134871.047 1 5 5 7 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;protein binding "Pf01344, Pf13415, Pf13418, Pf13854, Pf13964" 15161 ENSMUSG00000031386.14 Hcfc1 X HATs acetylate histones; UCH proteinases Herpes simplex infection 0 High Q68FD5 Clathrin heavy chain 1 OS=Mus musculus OX=10090 GN=Cltc PE=1 SV=3 0 20.17 5 7 16 7 1675 191.4 5.69 3 2 5 4 5 2 5 4 2157320.766 2595094.703 12845843.33 3072589.828 5 6 7 6 cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane;mitochondrion;vacuole protein binding;RNA binding;structural molecule activity "Pf00637, Pf01394, Pf04053, Pf09268, Pf13838" 67300 ENSMUSG00000047126.17 Cltc 11 "WNT5A-dependent internalization of FZD4; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Lysosome; Huntington's disease; Synaptic vesicle cycle; Bacterial invasion of epithelial cells 0 High Q8VC57 BTB/POZ domain-containing protein KCTD5 OS=Mus musculus OX=10090 GN=Kctd5 PE=1 SV=1 0 27.698 44 7 15 7 234 26.1 5.95 5 4 5 6 4 5 4917728.5 16305800.25 17175499.56 19307637.75 1 5 5 6 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol protein binding Pf02214 69259 Kctd5 17 0 High D3YUT3 40S ribosomal protein S19 (Fragment) OS=Mus musculus OX=10090 GN=Rps19 PE=1 SV=2 0 11.122 29 5 15 5 133 14.9 10.35 2 4 2 4 2 5 3 5 2301184.875 6056055.625 5275688.906 6676437.688 4 5 5 5 metabolic process ribosome structural molecule activity Pf01090 ENSMUSG00000040952.16 7 0 High E9Q0B5 Fc fragment of IgG-binding protein OS=Mus musculus OX=10090 GN=Fcgbp PE=1 SV=1 0 2.254 0 1 15 1 2583 275 5.03 1 1 1 1 2 5 4 4 73189205.75 75232660 108440050 62890216 1 1 1 1 protein binding "Pf00094, Pf01826, Pf08742, Pf12714" ENSMUSG00000047730.17 7 0 High P97496 SWI/SNF complex subunit SMARCC1 OS=Mus musculus OX=10090 GN=Smarcc1 PE=1 SV=2 0 21.06 9 7 15 3 1104 122.8 5.73 2 5 3 4 2 6 3 4 293513.25 424008.4375 610673.625 187953.7813 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding Pf04433 20588 ENSMUSG00000032481.16 Smarcc1 9 RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 High P50427 Steryl-sulfatase OS=Mus musculus OX=10090 GN=Sts PE=1 SV=1 0 39.839 20 11 15 11 624 66.5 8.5 11 15 33811025.25 11 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding "Pf00884, Pf01663, Pf14707" 20905 Sts X|Y Steroid hormone biosynthesis 0 High P14115 60S ribosomal protein L27a OS=Mus musculus OX=10090 GN=Rpl27a PE=1 SV=5 0 8.904 16 2 15 2 148 16.6 11.12 2 2 2 2 3 4 4 4 2765728.875 14112809 11597223 15092202 2 2 2 2 metabolic process cytosol;endoplasmic reticulum;membrane;ribosome RNA binding;structural molecule activity Pf00828 26451 ENSMUSG00000046364.14 Rpl27a 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High F8VQJ3 Laminin subunit gamma-1 OS=Mus musculus OX=10090 GN=Lamc1 PE=1 SV=1 0 23.944 6 7 15 7 1607 177.1 5.19 1 4 1 7 1 4 2 8 1457167.727 3414947.438 1927027.531 5558336.188 5 4 4 5 cell organization and biogenesis;cellular component movement;regulation of biological process cytoskeleton;extracellular catalytic activity;motor activity;protein binding;structural molecule activity "Pf00052, Pf00053, Pf00055, Pf00261, Pf01576, Pf04012, Pf05262, Pf05483, Pf05557, Pf05701, Pf06008, Pf06160, Pf08317, Pf10174, Pf12795, Pf13514, Pf13868, Pf13949" 226519 ENSMUSG00000026478.14 Lamc1 1 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); MET activates PTK2 signaling; Laminin interactions; Post-translational protein phosphorylation Focal adhesion; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Prion diseases; Amoebiasis 0 High Q9D1H7 Golgi to ER traffic protein 4 homolog OS=Mus musculus OX=10090 GN=Get4 PE=1 SV=2 0 24.598 29 7 15 7 327 36.5 5.41 3 6 4 3 7 5 290032.9688 6749228.875 6621625.313 7399787.344 2 6 6 6 Met-loss+Acetyl [N-Term] regulation of biological process;transport cytoplasm;cytosol protein binding Pf04190 67604 ENSMUSG00000025858.12 Get4 5 0 High P09405 Nucleolin OS=Mus musculus OX=10090 GN=Ncl PE=1 SV=2 0 15.546 10 7 15 7 707 76.7 4.75 1 7 3 2 1 8 4 2 2061226.781 8871581.813 7374937.313 6479845.094 5 6 6 6 regulation of biological process;response to stimulus;transport cell surface;cytoplasm;membrane;nucleus DNA binding;metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 17975 ENSMUSG00000026234.12 Ncl 1 Major pathway of rRNA processing in the nucleolus and cytosol 0 High P62983 Ubiquitin-40S ribosomal protein S27a OS=Mus musculus OX=10090 GN=Rps27a PE=1 SV=2 0 20.141 40 5 15 5 156 17.9 9.64 1 4 4 1 1 7 5 2 3313330.563 16059458.13 14805962.25 12663703.25 4 5 4 4 metabolic process cytoplasm;cytosol;membrane;nucleus;ribosome metal ion binding;protein binding;RNA binding;structural molecule activity "Pf00240, Pf01599, Pf11976, Pf13019, Pf13881, Pf14560" 78294; 619900; 100042019 ENSMUSG00000020460.15 Rps27a; Rps27a-ps2; LOC100042019 11; 9 "Termination of translesion DNA synthesis; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; NOD1/2 Signaling Pathway; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Ovarian tumor domain proteases; UCH proteinases; Stimuli-sensing channels; p75NTR recruits signalling complexes; Josephin domain DUBs; Spry regulation of FGF signaling; SRP-dependent cotranslational protein targeting to membrane; Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Activation of NF-kappaB in B cells; EGFR downregulation; Regulation of necroptotic cell death; Regulation of signaling by CBL; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Formation of a pool of free 40S subunits; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; NF-kB is activated and signals survival; Downstream TCR signaling; Association of licensing factors with the pre-replicative complex; Autodegradation of Cdh1 by Cdh1:APC/C; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Asymmetric localization of PCP proteins; Interleukin-1 family signaling; TNFR1-induced NFkappaB signaling pathway; G2/M Checkpoints; Regulation of PTEN localization; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Mus musculus biological processes; Regulation of PTEN stability and activity; APC-Cdc20 mediated degradation of Nek2A; Formation of the ternary complex, and subsequently, the 43S complex; Regulation of TP53 Activity through Methylation; E3 ubiquitin ligases ubiquitinate target proteins; Translesion synthesis by POLI; Interleukin-20 family signaling; Downregulation of ERBB4 signaling; Dual Incision in GG-NER; ER Quality Control Compartment (ERQC); Neddylation; Negative regulators of DDX58/IFIH1 signaling; Gap-filling DNA repair synthesis and ligation in TC-NER; APC/C:Cdc20 mediated degradation of Securin; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Oxidative Stress Induced Senescence; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Regulation of PLK1 Activity at G2/M Transition; Senescence-Associated Secretory Phenotype (SASP); Oncogene Induced Senescence; Formation of TC-NER Pre-Incision Complex; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; APC/C:Cdc20 mediated degradation of Cyclin B; Translation initiation complex formation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of FZD by ubiquitination; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Circadian Clock; Degradation of DVL; Degradation of AXIN; The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Endosomal Sorting Complex Required For Transport (ESCRT); Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Degradation of beta-catenin by the destruction complex; NRIF signals cell death from the nucleus; Autodegradation of the E3 ubiquitin ligase COP1; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; Regulation of innate immune responses to cytosolic DNA; GLI3 is processed to GLI3R by the proteasome; Translesion synthesis by POLK; Activated TLR4 signalling; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); DNA Damage Recognition in GG-NER; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Formation of Incision Complex in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Hedgehog ligand biogenesis; Regulation of RAS by GAPs; Activated NOTCH1 Transmits Signal to the Nucleus; Cyclin D associated events in G1; Dual incision in TC-NER; Negative regulation of MAPK pathway; Pink/Parkin Mediated Mitophagy; Cargo recognition for clathrin-mediated endocytosis; Ubiquitin-dependent degradation of Cyclin D1; Metalloprotease DUBs; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; M/G1 Transition; Negative regulation of MET activity; L13a-mediated translational silencing of Ceruloplasmin expression; Downregulation of ERBB2:ERBB3 signaling; activated TAK1 mediates p38 MAPK activation; Regulation of RUNX2 expression and activity; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Regulation of DNA replication; Glycogen synthesis; Dectin-1 mediated noncanonical NF-kB signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Orc1 removal from chromatin; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Regulation of TNFR1 signaling; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; Fanconi Anemia Pathway; HDR through Homologous Recombination (HRR); Iron uptake and transport; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Signalling by NGF; Downregulation of TGF-beta receptor signaling" Ribosome 0 High E9Q6B2 Coiled-coil domain-containing protein 85C OS=Mus musculus OX=10090 GN=Ccdc85c PE=1 SV=1 0 30.092 33 8 15 8 420 45.3 6.96 7 4 2 8 4 3 98556.25781 5520259 3903972.281 4612930.125 1 6 4 5 Met-loss+Acetyl [N-Term] development Pf10226 668158 ENSMUSG00000084883.1 Ccdc85c 12 0 High Q91YW3 DnaJ homolog subfamily C member 3 OS=Mus musculus OX=10090 GN=Dnajc3 PE=1 SV=1 0 35.355 25 10 15 10 504 57.4 5.85 10 15 74913.64063 560873.1172 416728.0938 18985849.81 1 2 1 10 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;organelle lumen enzyme regulator activity;protein binding "Pf00226, Pf00515, Pf13371, Pf13414, Pf13424, Pf14559" 100037258 ENSMUSG00000022136.7 Dnajc3 14 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation; Post-translational protein phosphorylation Influenza A; Protein processing in endoplasmic reticulum 0 High P68433 Histone H3.1 OS=Mus musculus OX=10090 GN=H3c1 PE=1 SV=2 0 4.565 18 3 15 3 136 15.4 11.12 1 3 2 2 2 6 4 3 14084450 78026548.5 77189664 18340126 2 3 2 2 cell organization and biogenesis;regulation of biological process chromosome;membrane;nucleus DNA binding;protein binding "Pf00125, Pf15630" 319153; 360198; 97908; 319152 ENSMUSG00000099517.1; ENSMUSG00000101355.1; ENSMUSG00000101972.1; ENSMUSG00000069265.2 Hist1h3i; Hist1h3a; Hist1h3g; Hist1h3h 13 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; Interleukin-7 signaling; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HATs acetylate histones; Oxidative Stress Induced Senescence; Meiotic Recombination; Senescence-Associated Secretory Phenotype (SASP); HDMs demethylate histones; PRC2 methylates histones and DNA; SIRT1 negatively regulates rRNA expression; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; NoRC negatively regulates rRNA expression; Meiotic Synapsis; RMTs methylate histone arginines; PKMTs methylate histone lysines; Mus musculus biological processes; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production Transcriptional misregulation in cancer; Alcoholism; Systemic lupus erythematosus 0 High O35129 Prohibitin-2 OS=Mus musculus OX=10090 GN=Phb2 PE=1 SV=1 0 30.385 34 9 15 9 299 33.3 9.83 3 2 9 3 2 10 913550.6406 2263413.563 3255788.688 12223906.44 3 5 6 6 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;membrane;mitochondrion;nucleus protein binding Pf01145 12034 ENSMUSG00000004264.17 Phb2 6 Processing of SMDT1 0 High P17751 Triosephosphate isomerase OS=Mus musculus OX=10090 GN=Tpi1 PE=1 SV=4 0 22.432 32 7 15 7 299 32.2 5.74 1 4 5 4 1 4 6 4 4063717.344 5978363.688 3309562.875 5121600.625 5 5 4 4 development;metabolic process cytosol;nucleus catalytic activity;protein binding Pf00121 21991 ENSMUSG00000023456.14 Tpi1 6 Gluconeogenesis; Glycolysis Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; Inositol phosphate metabolism; Carbon metabolism; Fructose and mannose metabolism 0 High Q9D517 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma OS=Mus musculus OX=10090 GN=Agpat3 PE=1 SV=2 0 31.686 26 10 15 10 376 43.3 8.51 1 2 9 1 2 12 467430.625 1947766.703 3169174.219 37444652.5 2 4 5 10 metabolic process endoplasmic reticulum;membrane;nucleus catalytic activity Pf01553 28169 ENSMUSG00000001211.15 Agpat3 10 Synthesis of PA; COPI-independent Golgi-to-ER retrograde traffic Phospholipase D signaling pathway; Metabolic pathways; Glycerophospholipid metabolism; Glycerolipid metabolism 0 High Q6ZWV7 60S ribosomal protein L35 OS=Mus musculus OX=10090 GN=Rpl35 PE=1 SV=1 0 11.876 27 4 15 4 123 14.5 11.05 3 4 2 2 3 5 3 4 4211697.906 8296193.75 8138067.25 8260138.688 3 3 3 3 metabolic process;response to stimulus membrane;ribosome RNA binding;structural molecule activity Pf00831 66489 ENSMUSG00000078193.2; ENSMUSG00000062997.6 Rpl35 2; 1 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A2AJT4 Arginine/serine-rich protein PNISR OS=Mus musculus OX=10090 GN=Pnisr PE=1 SV=1 0 18.367 10 6 15 6 805 92.1 10.01 4 5 2 4 4 5 2 4 3218736.406 5498552.406 2004024.406 2537985.688 5 6 4 4 cytosol;nucleus RNA binding 66625 ENSMUSG00000028248.15 Sfrs18; Pnisr 4 0 High Q8K194 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Mus musculus OX=10090 GN=Snrnp27 PE=1 SV=1 0 13.992 30 4 15 4 155 18.9 11.62 3 3 2 1 5 5 4 1 2668525 4181329.75 3364736.5 3047459.125 2 2 2 2 metabolic process nucleus;spliceosomal complex Pf08648 66618 ENSMUSG00000001158.13 Snrnp27 6 mRNA Splicing - Major Pathway Spliceosome 0 High P0DP27 Calmodulin-2 OS=Mus musculus OX=10090 GN=Calm2 PE=1 SV=1 0 12.297 22 2 14 2 149 16.8 4.22 2 2 2 5 5 4 540539.7734 3537814.406 3195183.656 5656954.125 1 2 2 2 regulation of biological process;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding "Pf00036, Pf08726, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658" 12315; 12313; 12314 ENSMUSG00000001175.13; ENSMUSG00000036438.12; ENSMUSG00000019370.10 Calm3; Calm1; Calm2 7; 12; 17 Oxytocin signaling pathway; Dopaminergic synapse; Ras signaling pathway; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Tuberculosis; Melanogenesis; Oocyte meiosis; Pertussis; Neurotrophin signaling pathway; cGMP-PKG signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Olfactory transduction; Phototransduction; Gastric acid secretion; Renin secretion; Circadian entrainment; Glioma; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 0 High P70372 ELAV-like protein 1 OS=Mus musculus OX=10090 GN=Elavl1 PE=1 SV=2 0 19.644 27 7 14 7 326 36.1 9.04 1 2 5 4 1 2 6 5 2684956.203 5536645.844 5101642.344 5265520.188 5 6 6 5 regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 15568 ENSMUSG00000040028.10 Elavl1 8 mRNA Splicing - Major Pathway; HuR (ELAVL1) binds and stabilizes mRNA AMPK signaling pathway 0 High Q5SRY7 F-box/WD repeat-containing protein 11 OS=Mus musculus OX=10090 GN=Fbxw11 PE=1 SV=1 0 21.249 15 7 14 7 542 62 7.12 3 5 5 3 6 5 4398058.5 25539420 29468155.81 11264402.38 1 5 5 6 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;protein binding "Pf00400, Pf00646, Pf08801, Pf12125, Pf12937" 103583 ENSMUSG00000020271.17 Fbxw11 11 Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Activation of NF-kappaB in B cells; Activated TLR4 signalling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Regulation of PLK1 Activity at G2/M Transition; Downstream TCR signaling; Interleukin-1 family signaling; Neddylation; MAP3K8 (TPL2)-dependent MAPK1/3 activation Wnt signaling pathway; Ubiquitin mediated proteolysis; Hippo signaling pathway; Circadian rhythm; Oocyte meiosis; Hedgehog signaling pathway 0 High P62754 40S ribosomal protein S6 OS=Mus musculus OX=10090 GN=Rps6 PE=1 SV=1 0 15.62 25 6 14 6 249 28.7 10.84 1 4 5 4 1 4 5 4 2724909.469 15228306.25 12436006.06 13828435.38 3 5 5 4 cell death;cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01092 667739; 20104; 105244208 ENSMUSG00000028495.14 Rps6-ps4; Rps6; LOC105244208 2; 4 mTOR signaling pathway; Ribosome; Insulin signaling pathway; Proteoglycans in cancer; HIF-1 signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance 0 High A2AFI3 "RNA-binding motif protein, X chromosome OS=Mus musculus OX=10090 GN=Rbmx PE=1 SV=1" 0 8.071 11 3 14 3 301 32.7 9.88 1 3 2 2 2 5 4 3 1540112.594 3497119.688 3108379.875 2201807.688 2 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex DNA binding;protein binding;RNA binding "Pf00076, Pf08081, Pf13893, Pf14259" 19655 ENSMUSG00000031134.16 Rbmx X 0 High E9Q4M2 Hormone-sensitive lipase OS=Mus musculus OX=10090 GN=Lipe PE=1 SV=1 0 24.325 11 8 14 8 1072 117.2 6.83 1 1 8 1 1 12 466500.2813 1933897.063 2194136.406 8171258.438 3 5 6 7 metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding "Pf06350, Pf07859, Pf10340, Pf12695" 16890 ENSMUSG00000003123.15 Lipe 7 0 High Q9D172 "Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial OS=Mus musculus OX=10090 GN=Gatd3a PE=1 SV=1" 0 27.629 35 6 14 6 266 28.1 8.78 3 2 6 3 2 9 2081447.188 4712344.75 4972758.406 20392376.38 4 4 5 5 mitochondrion Pf01965 28295; 102641949 ENSMUSG00000053329.7 D10Jhu81e; LOC100046684; LOC102641949 10 0 High E9Q1W3 Nebulin OS=Mus musculus OX=10090 GN=Neb PE=1 SV=1 0 5.198 0 1 14 1 7152 828.1 9.07 1 1 1 1 6 7 128036966 162725510 135361368 160564181 3 3 3 3 cell organization and biogenesis;regulation of biological process protein binding "Pf00880, Pf14604" 17996 ENSMUSG00000026950.17 Neb 2 Striated Muscle Contraction 0 High P52623 Uridine-cytidine kinase 1 OS=Mus musculus OX=10090 GN=Uck1 PE=1 SV=2 0 21.059 29 7 13 7 277 31 7.88 2 3 6 2 3 8 1834663.676 3280589.281 4289039.234 16089007.69 5 6 7 7 metabolic process cytosol catalytic activity;nucleotide binding "Pf00485, Pf13207, Pf13238" 22245 Uck1 2 Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High Q925U4 ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Mus musculus OX=10090 GN=Edem1 PE=1 SV=1 0 31.394 17 9 13 9 652 73.7 6.15 9 13 99030.45313 13661959.44 1 8 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf01532 192193 ENSMUSG00000030104.9 Edem1 6 ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 High B1ARA5 60S ribosomal protein L26 OS=Mus musculus OX=10090 GN=Rpl26 PE=1 SV=1 0 6.284 17 3 13 3 143 17 10.55 1 3 3 3 1 4 4 4 2366221.563 8652645.75 7321680.5 9442736.5 3 3 3 3 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;ribosome protein binding;RNA binding;structural molecule activity 19941 ENSMUSG00000060938.14 Rpl26 11 0 High P62911 60S ribosomal protein L32 OS=Mus musculus OX=10090 GN=Rpl32 PE=1 SV=2 0 15.505 33 4 13 4 135 15.9 11.33 1 3 2 3 1 5 2 5 2379880.484 11168551 9345083.375 13139133.94 5 4 5 4 metabolic process;response to stimulus membrane;ribosome RNA binding;structural molecule activity Pf01655 19951; 652989 ENSMUSG00000057841.5 Rpl32; Rpl32p 6; X L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8BHN3 Neutral alpha-glucosidase AB OS=Mus musculus OX=10090 GN=Ganab PE=1 SV=1 0 22.316 10 9 13 9 944 106.8 6.06 9 13 450633.4766 391689.7188 12985057 3 3 9 metabolic process endoplasmic reticulum;Golgi;membrane catalytic activity;protein binding;RNA binding "Pf01055, Pf13802" 14376 Ganab 19 Calnexin/calreticulin cycle Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High A0A1B0GSR9 L-lactate dehydrogenase OS=Mus musculus OX=10090 GN=Ldha PE=1 SV=1 0 19.022 28 7 13 7 315 34.6 8.56 3 4 2 4 3 4 2 4 6495253.563 5787906.328 2969520.656 10146419.13 6 6 5 6 metabolic process cytoplasm catalytic activity "Pf00056, Pf02866" ENSMUSG00000063229.15 7 0 High P53395 "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dbt PE=1 SV=2" 0 17.273 19 7 13 7 482 53.2 8.6 4 1 4 6 2 5 2434194.141 1773057.289 850210.4297 3862077.344 4 3 3 4 metabolic process mitochondrion;organelle lumen catalytic activity;protein binding "Pf00198, Pf00364, Pf02817" 13171 ENSMUSG00000000340.10 Dbt 3 Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism" 0 High Q6A0A9 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus OX=10090 GN=FAM120A PE=1 SV=2 0 21.946 7 5 13 5 1112 121.6 8.92 4 4 4 4 4 5 1218303.641 4407864.344 4169019.156 31726449.5 4 5 5 4 cytoplasm;cytosol;membrane;nucleus RNA binding Pf13458 218236 ENSMUSG00000038014.7 Fam120a 13 0 High Q9WTZ1 RING-box protein 2 OS=Mus musculus OX=10090 GN=Rnf7 PE=3 SV=1 0 13.432 28 2 13 2 113 12.7 5.44 2 2 2 2 3 4 3 3 3353394.75 4970466.875 4615152.563 4870511.313 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;protein binding "Pf12678, Pf12861, Pf13639" 19823 ENSMUSG00000051234.6 Rnf7 9 Neddylation Ubiquitin mediated proteolysis 0 High P17742 Peptidyl-prolyl cis-trans isomerase A OS=Mus musculus OX=10090 GN=Ppia PE=1 SV=2 0 12.627 24 4 13 4 164 18 7.9 1 4 3 4 1 4 3 5 1214357.172 1948573.406 1288143.875 3215658.25 4 4 3 4 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane;nucleus catalytic activity;protein binding;RNA binding Pf00160 268373 ENSMUSG00000071866.12 Ppia 11 Neutrophil degranulation; Basigin interactions 0 High Q8VDM6 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Mus musculus OX=10090 GN=Hnrnpul1 PE=1 SV=1 0 17.009 8 4 13 4 859 95.9 6.58 2 4 3 3 2 5 3 3 1222848.438 3208631.813 2968519.5 2349095.563 3 4 4 4 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf13671" 232989 ENSMUSG00000040725.13 Hnrnpul1 7 mRNA Splicing - Major Pathway Influenza A 0 Medium G3UYC6 Synaptotagmin-like protein 4 (Fragment) OS=Mus musculus OX=10090 GN=Sytl4 PE=1 SV=8 0.028 1.299 5 1 13 1 185 21.6 9.07 1 1 1 1 3 2 2 6 285728352 263387615 210636638.3 208765711 1 1 1 1 regulation of biological process;transport protein binding Pf02318 ENSMUSG00000031255.14 X 0 High E9PUK6 Serine/arginine repetitive matrix protein 1 OS=Mus musculus OX=10090 GN=Srrm1 PE=1 SV=1 0 15.817 7 5 13 4 923 104.2 11.85 4 3 2 1 6 3 3 1 9081220.719 26099106.94 18022840.23 18646018.88 4 4 5 4 metabolic process nucleus;spliceosomal complex DNA binding;RNA binding "Pf01480, Pf15449" 51796 ENSMUSG00000028809.16 Srrm1 4 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; RNA transport 1 High P07724 Serum albumin OS=Mus musculus OX=10090 GN=Alb PE=1 SV=3 0 14.419 11 5 13 5 608 68.6 6.07 1 3 5 2 1 3 6 3 647096.1094 2852181.781 5506510.688 3420590.25 3 5 5 5 cell communication;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus DNA binding;metal ion binding;protein binding Pf00273 11657 ENSMUSG00000029368.10 Alb 5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Platelet degranulation ; Transport of organic anions; HDL remodeling; Scavenging of heme from plasma Thyroid hormone synthesis 0 High Q62425 Cytochrome c oxidase subunit NDUFA4 OS=Mus musculus OX=10090 GN=Ndufa4 PE=1 SV=2 0 16.373 56 6 13 6 82 9.3 9.52 2 1 6 2 1 10 4152083.711 15354283.44 10764404.56 143702938.8 4 5 4 6 metabolic process;transport membrane;mitochondrion catalytic activity;protein binding;transporter activity Pf06522 17992 ENSMUSG00000029632.7 Ndufa4 6 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P62897 "Cytochrome c, somatic OS=Mus musculus OX=10090 GN=Cycs PE=1 SV=2" 0 10.037 30 3 13 3 105 11.6 9.58 2 2 2 3 3 3 2 5 993905.4063 1915285.156 1320890.938 3738858.125 2 3 2 3 cell death;metabolic process;regulation of biological process;transport cytosol;mitochondrion;nucleus metal ion binding;protein binding "Pf00034, Pf13442, Pf14495" 13063; 672195 ENSMUSG00000058927.5; ENSMUSG00000063694.5 Cycs; Gm10053 6; 19 Activation of caspases through apoptosome-mediated cleavage; Formation of apoptosome; Transcriptional activation of mitochondrial biogenesis; Cytochrome c-mediated apoptotic response; Detoxification of Reactive Oxygen Species; Release of apoptotic factors from the mitochondria; Respiratory electron transport; Apoptotic factor-mediated response Herpes simplex infection; Platinum drug resistance; p53 signaling pathway; Amyotrophic lateral sclerosis (ALS); Toxoplasmosis; Metabolic pathways; Small cell lung cancer; Tuberculosis; Hepatitis B; Huntington's disease; Sulfur metabolism; Apoptosis - multiple species; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Legionellosis; Pathways in cancer; Influenza A; Alzheimer's disease; Viral myocarditis; Colorectal cancer; Apoptosis 0 High P62259 14-3-3 protein epsilon OS=Mus musculus OX=10090 GN=Ywhae PE=1 SV=1 0 20.466 26 6 13 3 255 29.2 4.74 1 3 4 5 1 3 4 5 181591.5938 1804433.969 1244063.563 2333979.969 1 2 2 2 cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding;RNA binding Pf00244 22627 ENSMUSG00000020849.13 Ywhae 11 Activation of BAD and translocation to mitochondria ; Loss of Nlp from mitotic centrosomes; Recruitment of NuMA to mitotic centrosomes; TP53 Regulates Metabolic Genes; Signaling by Hippo; Translocation of GLUT4 to the plasma membrane; Anchoring of the basal body to the plasma membrane; Regulation of HSF1-mediated heat shock response; AURKA Activation by TPX2; RHO GTPases activate PKNs; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; RAB GEFs exchange GTP for GDP on RABs; Regulation of PLK1 Activity at G2/M Transition; NADE modulates death signalling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signalling by NGF Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Neurotrophin signaling pathway; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High P62082 40S ribosomal protein S7 OS=Mus musculus OX=10090 GN=Rps7 PE=2 SV=1 0 11.357 27 4 13 4 194 22.1 10.1 2 3 2 3 3 4 3 3 2873639.344 8571336.25 6379987.25 6346926.75 3 4 4 5 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01251 20115 ENSMUSG00000061477.3 Rps7 12 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9CQ69 Cytochrome b-c1 complex subunit 8 OS=Mus musculus OX=10090 GN=Uqcrq PE=1 SV=3 0 12.795 43 4 13 4 82 9.8 10.26 1 2 1 4 1 3 2 7 528443.1875 781627.875 673767.5625 15450823 1 1 1 4 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02939 22272 ENSMUSG00000044894.14 Uqcrq 11 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q99M28 RNA-binding protein with serine-rich domain 1 OS=Mus musculus OX=10090 GN=Rnps1 PE=1 SV=1 0 11.731 8 2 12 2 305 34.2 11.84 2 2 2 2 2 4 4 2 2664615.063 4992485.5 6326635.75 2945273.875 2 2 2 2 metabolic process;regulation of biological process cytoplasm;nucleus RNA binding "Pf00076, Pf08777, Pf11608, Pf13893, Pf14259" 19826 ENSMUSG00000034681.16 Rnps1 17 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; RNA transport 0 High P14211 Calreticulin OS=Mus musculus OX=10090 GN=Calr PE=1 SV=1 0 18.795 15 7 12 7 416 48 4.49 1 7 1 11 1478459.563 1060409.781 15097777 3 3 6 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus;organelle lumen metal ion binding;protein binding;RNA binding Pf00262 12317 ENSMUSG00000003814.8 Calr 8 "Calnexin/calreticulin cycle; Scavenging by Class A Receptors; ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" Chagas disease (American trypanosomiasis); HTLV-I infection; Phagosome; Antigen processing and presentation; Protein processing in endoplasmic reticulum 0 High A0A1W2P733 "C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus OX=10090 GN=Mthfd1 PE=1 SV=1" 0 30.509 18 10 12 10 755 82 7.23 1 1 10 1 1 10 848054.4531 2902407.883 3855903.688 13037591.91 3 7 8 10 metabolic process catalytic activity;nucleotide binding "Pf01268, Pf02882" ENSMUSG00000021048.7 12 0 High P14152 "Malate dehydrogenase, cytoplasmic OS=Mus musculus OX=10090 GN=Mdh1 PE=1 SV=3" 0 13.826 17 4 12 4 334 36.5 6.58 4 2 1 3 4 3 1 4 1946833.375 2461884.875 411609.2188 2619837.719 3 3 1 3 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding "Pf00056, Pf02866" 17449 ENSMUSG00000020321.15 Mdh1 11 Gluconeogenesis Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Cysteine and methionine metabolism; Proximal tubule bicarbonate reclamation; Carbon metabolism; Glyoxylate and dicarboxylate metabolism 0 High A0A0R4J0G0 "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Mus musculus OX=10090 GN=Pck2 PE=1 SV=1" 0 29.05 17 7 12 7 667 73.4 7.74 1 7 1 11 131522.6875 293628.5938 297706.375 7274390.563 1 1 1 4 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus mitochondrion catalytic activity;metal ion binding;nucleotide binding Pf00821 74551 ENSMUSG00000040618.6 Pck2 14 Gluconeogenesis FoxO signaling pathway; PPAR signaling pathway; Pyruvate metabolism; Citrate cycle (TCA cycle); Insulin signaling pathway; Metabolic pathways; Insulin resistance; Glycolysis / Gluconeogenesis; Proximal tubule bicarbonate reclamation; Adipocytokine signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Glucagon signaling pathway 0 High P80316 T-complex protein 1 subunit epsilon OS=Mus musculus OX=10090 GN=Cct5 PE=1 SV=1 0 24.507 20 8 12 8 541 59.6 6.02 1 8 1 11 785860.9844 1484271.07 1520266.156 6883826.469 2 4 4 7 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 12465 ENSMUSG00000022234.14 Cct5 15 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High P54116 Erythrocyte band 7 integral membrane protein OS=Mus musculus OX=10090 GN=Stom PE=1 SV=3 0 25.797 28 7 12 7 284 31.4 6.93 1 1 7 1 1 10 1150241.438 750371.9688 772940.5 16520549.03 2 2 2 6 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion protein binding Pf01145 13830 ENSMUSG00000026880.11 Stom 2 Neutrophil degranulation 0 High Q9CYH2 Peroxiredoxin-like 2A OS=Mus musculus OX=10090 GN=Prxl2a PE=1 SV=2 0 28.849 31 6 12 6 218 24.4 9.17 1 6 1 11 333034.7188 1040897.875 331128.1172 12182380.06 1 3 2 6 metabolic process;regulation of biological process cytoplasm;extracellular;mitochondrion antioxidant activity;catalytic activity "Pf00578, Pf13911" 70564 ENSMUSG00000021792.15 5730469M10Rik; Fam213a 14 0 High G5E8I8 Calcium homeostasis endoplasmic reticulum protein OS=Mus musculus OX=10090 GN=Cherp PE=1 SV=2 0 18.152 9 7 12 7 949 107.6 9.33 3 5 2 2 3 5 2 2 2011013.75 3604841.938 1893437.352 2572747.5 5 7 6 6 cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;endoplasmic reticulum;membrane protein binding;RNA binding "Pf01585, Pf01805, Pf04818" 27967 ENSMUSG00000052488.7 Cherp 8 mRNA Splicing - Major Pathway Spliceosome 0 High Q9JHP7 Protein O-glucosyltransferase 2 OS=Mus musculus OX=10090 GN=Poglut2 PE=1 SV=1 0 43.159 25 10 12 10 502 57.9 7.9 10 12 469754.5 44176.60938 11252593.5 1 1 7 metabolic process endoplasmic reticulum;organelle lumen catalytic activity;protein binding "Pf00630, Pf05686, Pf13524" 72050 ENSMUSG00000026047.13 Kdelc1 1 0 High Q9JIF7 Coatomer subunit beta OS=Mus musculus OX=10090 GN=Copb1 PE=1 SV=1 0 40.298 15 10 12 10 953 107 6 10 12 7442386 10896497 10458470.86 14479762.88 1 1 2 5 Met-loss+Acetyl [N-Term] transport cytoplasm;cytosol;Golgi;membrane structural molecule activity "Pf01602, Pf07718, Pf14806" 70349 ENSMUSG00000030754.9 Copb1 7 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation 0 High P40142 Transketolase OS=Mus musculus OX=10090 GN=Tkt PE=1 SV=1 0 32.024 14 8 12 8 623 67.6 7.5 1 8 1 11 926231.9375 1435758.156 1259896.5 10127764.34 4 3 3 8 metabolic process;regulation of biological process membrane catalytic activity;metal ion binding;protein binding "Pf00456, Pf00676, Pf02779, Pf02780" 21881 ENSMUSG00000021957.6 Tkt 14 Pentose phosphate pathway (hexose monophosphate shunt); Insulin effects increased synthesis of Xylulose-5-Phosphate Metabolic pathways; Biosynthesis of amino acids; Pentose phosphate pathway; Carbon metabolism 0 High Q9CQR4 Acyl-coenzyme A thioesterase 13 OS=Mus musculus OX=10090 GN=Acot13 PE=1 SV=1 0 8.582 23 3 12 3 140 15.2 8.82 2 2 3 3 2 3 3 4 5005187.156 9039934.375 7587553.688 9682734.25 3 3 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus catalytic activity Pf03061 66834 ENSMUSG00000006717.6 Acot13 13 Mitochondrial Fatty Acid Beta-Oxidation 0 High A0A1L1SQA8 40S ribosomal protein S25 OS=Mus musculus OX=10090 GN=Rps25 PE=1 SV=1 0 8.904 22 3 12 3 93 10.3 9.99 2 3 2 1 2 6 3 1 9053384.375 11562439.13 10065332.06 12384372.38 3 3 3 3 Pf03297 ENSMUSG00000009927.9 9 0 High Q9Z2Z6 Mitochondrial carnitine/acylcarnitine carrier protein OS=Mus musculus OX=10090 GN=Slc25a20 PE=1 SV=1 0 15.621 37 8 12 8 301 33 9.11 1 1 8 1 1 10 1365238.039 2553080.234 2258489.625 13487762.66 3 5 4 7 Met-loss+Acetyl [N-Term] transport cytosol;membrane;mitochondrion transporter activity Pf00153 57279 ENSMUSG00000032602.6 Slc25a20 9 Import of palmitoyl-CoA into the mitochondrial matrix 0 High P62264 40S ribosomal protein S14 OS=Mus musculus OX=10090 GN=Rps14 PE=1 SV=3 0 22.802 33 5 12 5 151 16.3 10.05 4 2 3 4 2 6 1196657.406 4505851.656 3135217.656 8002222.656 4 4 3 4 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process membrane;mitochondrion;ribosome RNA binding;structural molecule activity;translation regulator activity Pf00411 20044 ENSMUSG00000024608.10 Rps14 18 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P01899 "H-2 class I histocompatibility antigen, D-B alpha chain OS=Mus musculus OX=10090 GN=H2-D1 PE=1 SV=2" 0 21.83 23 7 12 4 362 40.8 6.73 2 1 7 2 1 9 1269025.813 637800.7656 18542122.81 3 3 7 regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane protein binding;RNA binding "Pf00129, Pf06623, Pf07654, Pf08205" 14964 ENSMUSG00000073411.11 H2-D1 17 Endocytosis; Herpes simplex infection; Allograft rejection; Epstein-Barr virus infection; Cell adhesion molecules (CAMs); HTLV-I infection; Phagosome; Graft-versus-host disease; Viral myocarditis; Antigen processing and presentation; Type I diabetes mellitus; Natural killer cell mediated cytotoxicity; Autoimmune thyroid disease; Viral carcinogenesis 3 High Q62093 Serine/arginine-rich splicing factor 2 OS=Mus musculus OX=10090 GN=Srsf2 PE=1 SV=4 0 12.325 22 4 11 4 221 25.5 11.85 3 2 2 2 3 2 3 3 5259884.828 4452534.406 3332793.156 2994136.094 3 3 3 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytosol;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 20382 ENSMUSG00000034120.18 Srsf2 11 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High Q8R180 ERO1-like protein alpha OS=Mus musculus OX=10090 GN=Ero1a PE=1 SV=2 0 32.638 24 9 11 9 464 54.1 6.54 9 11 144042.3438 406579.7188 524734.9844 17701953.19 1 2 2 9 cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity Pf04137 50527 ENSMUSG00000021831.8 Ero1l 14 Insulin processing; Detoxification of Reactive Oxygen Species Protein processing in endoplasmic reticulum 0 High Q9CQ39 Mediator of RNA polymerase II transcription subunit 21 OS=Mus musculus OX=10090 GN=Med21 PE=1 SV=1 0 16.823 44 3 11 3 144 15.6 4.53 1 2 2 3 1 3 3 4 425660.4688 2152837.969 1799743.844 2725878.281 2 2 2 2 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf11221 108098 ENSMUSG00000030291.12 Med21 6 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High P35550 rRNA 2'-O-methyltransferase fibrillarin OS=Mus musculus OX=10090 GN=Fbl PE=1 SV=2 0 15.251 21 5 11 5 327 34.3 10.24 2 4 5 2 4 5 495514.3906 2731902.438 3259745 3818144.906 2 4 4 5 cell differentiation;cell organization and biogenesis;metabolic process chromosome;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf01135, Pf01269, Pf13847" 14113; 102643269 ENSMUSG00000046865.7 LOC100044829; Fbl; LOC102643269 7; 3 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High Q9CQ62 "2,4-dienoyl-CoA reductase, mitochondrial OS=Mus musculus OX=10090 GN=Decr1 PE=1 SV=1" 0 15.514 13 3 11 3 335 36.2 8.95 1 3 3 3 1 3 3 4 708032.375 3535619 3461510.563 7266379.75 2 3 3 3 cell organization and biogenesis;metabolic process cytosol;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00106, Pf08659, Pf13561" 67460 ENSMUSG00000028223.8 Decr1 4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 0 High O09164 Extracellular superoxide dismutase [Cu-Zn] OS=Mus musculus OX=10090 GN=Sod3 PE=1 SV=1 0 37.337 46 5 11 5 251 27.4 6.84 5 11 465070.4688 132665.7031 21454169.56 2 1 5 metabolic process;response to stimulus cytoplasm;extracellular;nucleus;organelle lumen antioxidant activity;catalytic activity;metal ion binding;protein binding Pf00080 20657 ENSMUSG00000072941.5 Sod3 5 Detoxification of Reactive Oxygen Species 0 High P19783 "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Mus musculus OX=10090 GN=Cox4i1 PE=1 SV=2" 0 23.465 36 6 11 6 169 19.5 9.23 2 6 2 9 837235.2422 2013463.281 2518871.469 25629377.5 3 4 5 6 metabolic process;response to stimulus;transport membrane;mitochondrion;nucleus catalytic activity;transporter activity Pf02936 12857 ENSMUSG00000031818.12 Cox4i1 8 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q542V3 Serine/arginine-rich-splicing factor 4 OS=Mus musculus OX=10090 GN=Srsf4 PE=1 SV=1 0 8.576 9 4 11 2 491 56.2 11.37 2 2 2 3 2 3 3 3 1183333.414 1829600.25 2707687.813 1256850.125 2 1 2 2 cell differentiation;metabolic process;regulation of biological process;response to stimulus nucleus RNA binding "Pf00076, Pf13893, Pf14259" 57317 ENSMUSG00000028911.16 Srsf4 4 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High P97807 "Fumarate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Fh PE=1 SV=3" 0 23.675 18 6 11 6 507 54.3 9.04 2 1 6 3 1 7 307231.4375 2831561.375 1042348.875 7113449.875 1 5 3 6 metabolic process cytoplasm;mitochondrion catalytic activity "Pf00206, Pf10415" 14194 ENSMUSG00000026526.14 Fh1 1 Citric acid cycle (TCA cycle) Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Pathways in cancer; Renal cell carcinoma; Carbon metabolism 0 High Q8R310 Transmembrane and coiled-coil domain protein 3 OS=Mus musculus OX=10090 GN=Tmcc3 PE=1 SV=2 0 10.441 13 5 11 5 477 53.7 8.6 5 3 2 6 3 2 2703089.406 3175147.938 2202996.5 3695340.484 5 5 4 4 membrane Pf10267 319880 ENSMUSG00000020023.18 Tmcc3 10 0 High Q91YQ5 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Mus musculus OX=10090 GN=Rpn1 PE=1 SV=1 0 42.963 19 9 11 9 608 68.5 6.46 9 11 290251.5 766452.4688 1024648.344 14400769.44 2 3 3 8 metabolic process cytosol;endoplasmic reticulum;membrane catalytic activity;RNA binding Pf04597 103963 ENSMUSG00000030062.7 Rpn1 6 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High G3UW94 Splicing factor U2AF 35 kDa subunit OS=Mus musculus OX=10090 GN=U2af1 PE=1 SV=1 0 14.961 11 2 11 2 239 27.8 8.68 2 2 2 2 3 3 3 2 1235151.094 2586687.875 2356016.594 1229563 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process nucleus;spliceosomal complex metal ion binding;protein binding;RNA binding "Pf00076, Pf00642, Pf13893" 108121 ENSMUSG00000061613.12 U2af1 17 Spliceosome 0 High Q8K1F9 Lactase-like protein OS=Mus musculus OX=10090 GN=Lctl PE=1 SV=1 0 29.19 16 7 11 7 566 64.8 6.77 7 11 2697402.25 16062142 1 7 metabolic process endoplasmic reticulum;membrane catalytic activity Pf00232 235435 ENSMUSG00000032401.15 Lctl 9 0 High C0HK80 Adipocyte-related X-chromosome expressed sequence 2 OS=Mus musculus OX=10090 GN=Arxes2 PE=1 SV=1 0 13.251 26 5 11 5 180 20.1 9.6 5 11 1147280.938 47285442.25 2 4 cell differentiation;metabolic process;transport endoplasmic reticulum;membrane catalytic activity Pf04573 76219; 76976 ENSMUSG00000048040.8; ENSMUSG00000048355.2 Arxes1; Arxes2 X Protein export 0 High P62267 40S ribosomal protein S23 OS=Mus musculus OX=10090 GN=Rps23 PE=1 SV=3 0 7.781 36 3 11 3 143 15.8 10.49 2 1 2 2 3 2 3 3 2684019.5 7157660.25 5888387.875 6786758.625 2 2 2 2 cell organization and biogenesis;metabolic process membrane;ribosome RNA binding;structural molecule activity Pf00164 66475 ENSMUSG00000049517.7 Rps23 13 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High C0HKD9 Microfibrillar-associated protein 1B OS=Mus musculus OX=10090 GN=Mfap1b PE=1 SV=1 0 14.562 18 5 11 5 439 51.9 4.98 5 3 2 1 5 3 2 1 2475271.375 2855026.281 1491203.938 1093215.125 4 4 3 2 nucleus RNA binding Pf06991 67532; 100034361 ENSMUSG00000048222.3; ENSMUSG00000068479.5 Mfap1a; Mfap1b 2 Molecules associated with elastic fibres 0 High E9Q133 T-complex protein 1 subunit gamma OS=Mus musculus OX=10090 GN=Cct3 PE=1 SV=1 0 19.635 12 5 11 5 507 56.5 6.7 1 3 5 1 3 7 580892.6484 937618.3438 1332665.75 4165549.688 3 3 4 4 cell organization and biogenesis;metabolic process;transport cytoplasm nucleotide binding;protein binding Pf00118 ENSMUSG00000001416.13 3 0 High Q925J9 Mediator of RNA polymerase II transcription subunit 1 OS=Mus musculus OX=10090 GN=Med1 PE=1 SV=2 0 15.499 6 7 11 7 1575 167 8.73 1 3 5 2 3 6 1083255.469 3333136.953 2237708.609 5208746.719 5 7 6 7 cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport chromosome;membrane;nucleus catalytic activity;DNA binding;protein binding;receptor activity Pf10744 19014 ENSMUSG00000018160.15 Med1 11 Nuclear Receptor transcription pathway; Mus musculus biological processes; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha); Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway; Endocrine resistance 0 High E9Q1J7 "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Mus musculus OX=10090 GN=Pccb PE=1 SV=1" 0 27.923 13 5 11 5 504 54.6 7.49 1 2 2 5 1 2 2 6 1992350.25 2721319.438 2914703.625 5676499.625 5 4 5 4 metabolic process mitochondrion catalytic activity;nucleotide binding Pf01039 66904 ENSMUSG00000032527.13 Pccb 9 0 High P67984 60S ribosomal protein L22 OS=Mus musculus OX=10090 GN=Rpl22 PE=1 SV=2 0 14.623 39 3 11 3 128 14.8 9.19 2 2 2 3 3 2 2 4 12182880 12253627.75 13521092.69 13252856.88 2 2 3 3 cell differentiation;metabolic process cytoplasm;nucleus;ribosome RNA binding;structural molecule activity Pf01776 19934; 100047372; 102642602 ENSMUSG00000028936.15 Rpl22; LOC100047372; LOC100504863; LOC102642602 4; 7 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A0A0U1RP81 MICOS complex subunit MIC60 OS=Mus musculus OX=10090 GN=Immt PE=1 SV=1 0 25.803 19 6 11 2 488 53.7 8.66 1 2 6 1 2 8 838175.0938 2 cellular homeostasis membrane;mitochondrion Pf09731 ENSMUSG00000052337.15 6 0 High P70428 Exostosin-2 OS=Mus musculus OX=10090 GN=Ext2 PE=1 SV=2 0 34.65 16 9 11 9 718 82 6.65 9 11 12883126.31 7 cell differentiation;metabolic process endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding "Pf03016, Pf09258" 14043 ENSMUSG00000027198.16 Ext2 2 HS-GAG biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 High G3UX26 Voltage-dependent anion-selective channel protein 2 OS=Mus musculus OX=10090 GN=Vdac2 PE=1 SV=1 0 15.364 17 5 11 5 283 30.4 7.58 2 4 4 2 4 5 441277.1563 2710563.5 4518883.75 5982838.063 2 4 4 4 transport membrane transporter activity Pf01459 ENSMUSG00000021771.13 14 0 High Q9R112 "Sulfide:quinone oxidoreductase, mitochondrial OS=Mus musculus OX=10090 GN=Sqor PE=1 SV=3" 0 29.279 21 8 11 8 450 50.3 9.09 1 8 1 10 5375166.352 5140180.734 14078670.88 4 6 7 metabolic process membrane;mitochondrion catalytic activity "Pf07992, Pf13738" 59010 ENSMUSG00000005803.14 Sqrdl; Sqor 2 Sulfide oxidation to sulfate Sulfur metabolism 0 High P84104 Serine/arginine-rich splicing factor 3 OS=Mus musculus OX=10090 GN=Srsf3 PE=1 SV=1 0 4.743 16 3 11 3 164 19.3 11.65 2 3 1 1 3 4 2 2 3844905.234 9451327.313 9207325.594 5317486.875 3 3 3 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 20383 ENSMUSG00000071172.12 Srsf3 17 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High P35486 "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha1 PE=1 SV=1" 0 17.678 13 5 11 5 390 43.2 8.19 1 1 2 5 1 1 3 6 2025052.453 5579606.102 5130848.281 12813832.63 4 5 5 5 metabolic process mitochondrion;nucleus;organelle lumen catalytic activity Pf00676 18597 ENSMUSG00000031299.10 Pdha1 X Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 0 High O54734 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Mus musculus OX=10090 GN=Ddost PE=1 SV=2 0 30.434 35 9 11 9 441 49 5.83 9 11 1455477.844 1162837.391 28393326.47 4 4 9 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf03345 13200 ENSMUSG00000028757.4 Ddost 4 Neutrophil degranulation Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High F8VPL5 Mitogen-activated protein kinase kinase kinase kinase 4 OS=Mus musculus OX=10090 GN=Map4k4 PE=1 SV=2 0 8.033 4 5 11 5 1238 141.7 7.44 4 3 1 1 4 4 1 2 6904761.672 9471134.344 9459335.469 6455569.453 5 5 5 4 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00780, Pf07714" 26921 ENSMUSG00000026074.14 Map4k4 1 0 High Q9CZ82 Mediator of RNA polymerase II transcription subunit 18 OS=Mus musculus OX=10090 GN=Med18 PE=1 SV=1 0 8.531 12 2 11 2 208 23.6 6.54 2 2 2 4 4 3 824456.2969 3242083.813 2642821.688 4126100.813 2 2 2 2 metabolic process;regulation of biological process nucleus catalytic activity Pf09637 67219 ENSMUSG00000066042.4 Med18 4 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High P32067 Lupus La protein homolog OS=Mus musculus OX=10090 GN=Ssb PE=1 SV=1 0 6.489 12 5 10 5 415 47.7 9.77 1 4 2 2 1 5 2 2 655890.4609 2515306.578 2272491.852 1926554.391 4 5 5 4 metabolic process;transport cytoplasm;nucleus RNA binding "Pf00076, Pf05383, Pf08777, Pf14259" 20823 ENSMUSG00000068882.13 Ssb 2 Systemic lupus erythematosus 0 High P62849 40S ribosomal protein S24 OS=Mus musculus OX=10090 GN=Rps24 PE=1 SV=1 0 7.438 14 2 10 2 133 15.4 10.78 2 1 1 2 2 3 2 3 779829.375 2803612 2473356.625 1967772 2 2 2 2 Acetyl [N-Term] metabolic process membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity Pf01282 20088; 102642752 ENSMUSG00000025290.16 Rps24; LOC677113; LOC102642752 14; 16 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q61881 DNA replication licensing factor MCM7 OS=Mus musculus OX=10090 GN=Mcm7 PE=1 SV=1 0 23.734 14 8 10 8 719 81.2 6.37 1 1 8 1 1 8 232788.9063 1090307.141 1253613.156 4682395.375 2 4 5 7 cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 17220 ENSMUSG00000029730.16 Mcm7 5 Removal of licensing factors from origins; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Orc1 removal from chromatin; M/G1 Transition; Activation of ATR in response to replication stress; Regulation of DNA replication DNA replication; Cell cycle 0 High A0A0R4J0Z1 Protein disulfide-isomerase A4 OS=Mus musculus OX=10090 GN=Pdia4 PE=1 SV=1 0 24.742 15 9 10 9 641 72.3 5.22 9 10 451571.5469 594892.0313 268853.0938 14923122.66 2 2 1 6 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding;RNA binding "Pf00085, Pf01216, Pf13098, Pf13848, Pf13905" 12304 ENSMUSG00000025823.9 Pdia4 6 Thyroid hormone synthesis; Protein processing in endoplasmic reticulum 0 High Q9CYD3 Cartilage-associated protein OS=Mus musculus OX=10090 GN=Crtap PE=1 SV=3 0 20.127 19 7 10 7 400 46.1 5.71 7 10 223713.1641 664141.6953 586664.9766 17842749 2 3 3 7 metabolic process;regulation of biological process endoplasmic reticulum;extracellular protein binding 56693 ENSMUSG00000032431.6 Crtap 9 Collagen biosynthesis and modifying enzymes 0 High Q8VCT4 Carboxylesterase 1D OS=Mus musculus OX=10090 GN=Ces1d PE=1 SV=1 0 24.138 18 9 10 9 565 61.7 6.61 9 10 10370364.91 8 cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;organelle lumen catalytic activity "Pf00135, Pf00326, Pf00756, Pf07859, Pf12695" 104158 ENSMUSG00000056973.6 Ces1d 8 Phase I - Functionalization of compounds Metabolic pathways; Drug metabolism - other enzymes 0 High D3Z4W5 RIKEN cDNA 1700074P13 gene (Fragment) OS=Mus musculus OX=10090 GN=1700074P13Rik PE=3 SV=1 0 3.035 4 1 10 1 176 20.1 5.06 1 1 1 4 4 2 114598 12294965.47 12051412.34 11233327.34 1 2 2 2 metabolic process Golgi catalytic activity Pf00089 ENSMUSG00000029883.12 6 0 High Q9EPU0 Regulator of nonsense transcripts 1 OS=Mus musculus OX=10090 GN=Upf1 PE=1 SV=2 0 11.126 5 5 10 5 1124 123.9 6.61 3 2 3 3 3 4 394993.7539 1848525.297 1201141.781 2489021.875 3 5 4 4 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytosol;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf04851, Pf09416, Pf13086, Pf13087, Pf13245, Pf13604" 19704 ENSMUSG00000058301.8 Upf1 8 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA surveillance pathway; RNA transport 0 High Q569Z6 Thyroid hormone receptor-associated protein 3 OS=Mus musculus OX=10090 GN=Thrap3 PE=1 SV=1 0 14.509 6 4 10 4 951 108.1 10.17 2 3 3 2 2 3 3 2 2425454.063 3657326.688 3284942.25 2507012.625 5 4 4 3 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;nucleotide binding;protein binding;receptor activity;RNA binding Pf15440 230753 ENSMUSG00000043962.16 Thrap3 4 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High A2A6A1 G patch domain-containing protein 8 OS=Mus musculus OX=10090 GN=Gpatch8 PE=1 SV=1 0 9.881 3 4 10 4 1505 164.9 7.64 1 3 4 2 1 3 4 2 832363.1406 1089357.734 1020405.953 859672.0469 3 3 3 3 metal ion binding;protein binding;RNA binding "Pf12171, Pf13868" 237943 ENSMUSG00000034621.14 Gpatch8 11 0 High Q9JJY4 Probable ATP-dependent RNA helicase DDX20 OS=Mus musculus OX=10090 GN=Ddx20 PE=1 SV=2 0 24.123 12 7 10 7 825 91.7 6.74 2 7 2 8 2418465.828 1399076.266 4730055.969 3 3 4 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00270, Pf00271" 53975 ENSMUSG00000027905.15 Ddx20 3 snRNP Assembly RNA transport 0 High Q61753 D-3-phosphoglycerate dehydrogenase OS=Mus musculus OX=10090 GN=Phgdh PE=1 SV=3 0 23.885 14 6 10 6 533 56.5 6.54 1 2 6 1 2 7 707694.1719 1932577.156 2579465.844 11442229.56 2 3 5 6 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process catalytic activity;nucleotide binding "Pf00389, Pf02826" 236539 ENSMUSG00000053398.11 Phgdh 3 Serine biosynthesis "Metabolic pathways; Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Carbon metabolism" 0 High P68510 14-3-3 protein eta OS=Mus musculus OX=10090 GN=Ywhah PE=1 SV=2 0 11.957 20 5 10 1 246 28.2 4.89 1 4 2 3 1 4 2 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane protein binding Pf00244 22629 ENSMUSG00000018965.11 Ywhah 5 Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Epstein-Barr virus infection; Hippo signaling pathway; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High Q9JKB3 Y-box-binding protein 3 OS=Mus musculus OX=10090 GN=Ybx3 PE=1 SV=2 0 14.581 12 3 10 1 361 38.8 9.69 3 3 5 5 882581.125 578582.0625 414332.7813 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus DNA binding;protein binding;RNA binding Pf00313 56449 ENSMUSG00000030189.15 Csda; Ybx3 6 Tight junction 0 High Q8CIE6 Coatomer subunit alpha OS=Mus musculus OX=10090 GN=Copa PE=1 SV=2 0 19.304 6 7 10 7 1224 138.3 7.65 2 1 7 2 1 7 601318.6953 2139921.5 2093307.203 6749080.313 4 7 7 7 regulation of biological process;transport cytoplasm;extracellular;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053, Pf06957" 12847 ENSMUSG00000026553.17 Copa 1 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q99K48 Non-POU domain-containing octamer-binding protein OS=Mus musculus OX=10090 GN=Nono PE=1 SV=3 0 11.609 12 5 10 4 473 54.5 8.95 2 4 1 3 5 2 340671.9063 4841368.688 2175170.75 411489.5313 2 4 3 2 defense response;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf08075, Pf13893, Pf14259" 53610 ENSMUSG00000031311.17 Nono X 0 High Q64435 UDP-glucuronosyltransferase 1-6 OS=Mus musculus OX=10090 GN=Ugt1a6 PE=1 SV=1 0 31.266 17 7 10 1 531 60.4 8.62 7 10 197741.125 432673.2188 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00201, Pf04101" 94284 ENSMUSG00000090124.7; ENSMUSG00000054545.17 Ugt1a6a 1 Glucuronidation Steroid hormone biosynthesis; Drug metabolism - cytochrome P450; Retinol metabolism; Metabolic pathways; Drug metabolism - other enzymes; Ascorbate and aldarate metabolism; Chemical carcinogenesis; Porphyrin and chlorophyll metabolism; Pentose and glucuronate interconversions; Metabolism of xenobiotics by cytochrome P450 0 High Q3TQC7 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Mus musculus OX=10090 GN=Entpd5 PE=1 SV=1 0 25.913 21 7 10 7 452 49.8 5.47 1 7 1 9 336823.1484 468040.5 9229137.125 2 2 5 cell growth;cell proliferation;metabolic process;regulation of biological process endoplasmic reticulum;extracellular;membrane catalytic activity Pf01150 12499 ENSMUSG00000021236.16 Entpd5 12 0 High O08807 Peroxiredoxin-4 OS=Mus musculus OX=10090 GN=Prdx4 PE=1 SV=1 0 4.721 7 2 10 1 274 31 7.15 1 2 1 2 2 3 2 3 1558059.875 1739560.375 2465393.5 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 53381 ENSMUSG00000025289.15 Prdx4 X Neutrophil degranulation 0 High Q60994 Adiponectin OS=Mus musculus OX=10090 GN=Adipoq PE=1 SV=2 0 13.588 19 4 10 4 247 26.8 5.57 4 10 98446.88281 388770.2656 133348.1563 18502356 2 3 1 4 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;extracellular protein binding "Pf00386, Pf01391" 11450 ENSMUSG00000022878.5 Adipoq 16 AMPK inhibits chREBP transcriptional activation activity PPAR signaling pathway; Type II diabetes mellitus; Longevity regulating pathway; Non-alcoholic fatty liver disease (NAFLD); Adipocytokine signaling pathway; AMPK signaling pathway 0 High F8WIP7 Zinc finger protein ubi-d4 (Fragment) OS=Mus musculus OX=10090 GN=Dpf2 PE=1 SV=1 0 8.968 19 3 10 3 214 24.4 7.87 2 3 2 1 2 4 3 1 816417.2344 1182031.719 1019628.984 1023419.344 3 3 3 3 metal ion binding "Pf13894, Pf14051" ENSMUSG00000024826.14 19 0 High A0A0R4J025 RCC1 and BTB domain-containing protein 1 OS=Mus musculus OX=10090 GN=Rcbtb1 PE=1 SV=1 0 14.618 10 4 10 3 531 58.3 6.43 2 1 2 4 2 1 3 4 1778741.031 1230326.813 1345011.125 2797011.5 3 2 2 3 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding "Pf00415, Pf00651, Pf13540" 71330 ENSMUSG00000035469.17 Rcbtb1 14 0 High P63101 14-3-3 protein zeta/delta OS=Mus musculus OX=10090 GN=Ywhaz PE=1 SV=1 0 12.823 20 5 10 2 245 27.8 4.79 1 2 2 5 1 2 2 5 1458606.219 1121516.203 2022623.625 2 2 2 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;mitochondrion;nucleus protein binding;RNA binding Pf00244 22631 ENSMUSG00000022285.16 Ywhaz 15 "Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; Deactivation of the beta-catenin transactivating complex; RHO GTPases activate PKNs; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Interleukin-3, 5 and GM-CSF signaling" Epstein-Barr virus infection; Hippo signaling pathway; Hepatitis B; Oocyte meiosis; Cell cycle; PI3K-Akt signaling pathway; Viral carcinogenesis 0 High P84099 60S ribosomal protein L19 OS=Mus musculus OX=10090 GN=Rpl19 PE=1 SV=1 0 19.933 23 5 10 5 196 23.5 11.47 1 4 2 3 1 4 2 3 2254317.016 9892480.875 7546716.125 9457268.438 5 5 5 5 metabolic process membrane;ribosome RNA binding;structural molecule activity Pf01280 19921; 100041511 ENSMUSG00000017404.12 Rpl19; Rpl19-ps11 11; 8 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High A2AJR5 Receptor protein serine/threonine kinase OS=Mus musculus OX=10090 GN=Acvr1c PE=3 SV=1 0 25.546 20 7 10 7 413 46.1 7.46 7 10 559869.75 292556.0313 644693.1172 19898059.56 2 1 2 7 cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00069, Pf01064, Pf07714, Pf08515" 269275 ENSMUSG00000026834.13 Acvr1c 2 0 High Q6P3A8 "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Mus musculus OX=10090 GN=Bckdhb PE=1 SV=2" 0 25.575 16 4 10 4 390 42.9 6.7 2 1 4 2 1 7 906021.1328 2199990.734 597857.0352 6367518.469 3 3 2 3 metabolic process membrane;mitochondrion;organelle lumen catalytic activity;protein binding "Pf02779, Pf02780" 12040 ENSMUSG00000032263.14 Bckdhb 9 Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism" 0 High E9Q8F0 RNA-binding protein 39 OS=Mus musculus OX=10090 GN=Rbm39 PE=1 SV=1 0 8.895 8 3 10 3 415 47 10.52 1 3 2 2 1 3 3 3 813342.6641 2305448.719 2114755.797 2521699.813 3 3 3 2 Met-loss+Acetyl [N-Term] metabolic process nucleus RNA binding "Pf00076, Pf13893, Pf14259, Pf15519" ENSMUSG00000027620.16 2 0 High Q8BHY2 Nucleolar complex protein 4 homolog OS=Mus musculus OX=10090 GN=Noc4l PE=2 SV=1 0 19.24 14 4 10 4 516 58.6 6.77 1 2 4 2 3 5 2025175.313 3255436.75 4535034.438 2 3 3 metabolic process membrane;nucleus RNA binding Pf03914 100608 ENSMUSG00000033294.11 Noc4l 5 Major pathway of rRNA processing in the nucleolus and cytosol 0 High K9J7B2 UDP-glucuronosyltransferase OS=Mus musculus OX=10090 GN=Ugt1a6b PE=1 SV=1 0 30.706 17 7 10 1 531 60.5 8.69 7 10 54089.65625 10249551.88 1 5 metabolic process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00201, Pf04101" 394435 ENSMUSG00000090145.7 Ugt1a6b 1 Glucuronidation Steroid hormone biosynthesis; Drug metabolism - cytochrome P450; Retinol metabolism; Metabolic pathways; Drug metabolism - other enzymes; Ascorbate and aldarate metabolism; Chemical carcinogenesis; Porphyrin and chlorophyll metabolism; Pentose and glucuronate interconversions; Metabolism of xenobiotics by cytochrome P450 4 High Q9DB40 Mediator of RNA polymerase II transcription subunit 27 OS=Mus musculus OX=10090 GN=Med27 PE=2 SV=2 0 14.8 15 4 10 4 311 35.3 9.31 1 2 3 2 1 2 4 3 956237.9453 2825415.625 2561824.063 3515733.375 2 3 3 3 metabolic process;regulation of biological process cytosol;nucleus catalytic activity Pf11571 68975 ENSMUSG00000026799.15 Med27 2 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway 0 High O35130 Ribosomal RNA small subunit methyltransferase NEP1 OS=Mus musculus OX=10090 GN=Emg1 PE=1 SV=1 0 13.314 22 4 10 4 244 27 8.91 3 3 3 3 3 4 2038672.5 2018671.313 3256295.313 3 3 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process nucleus catalytic activity;RNA binding Pf03587 14791 ENSMUSG00000004268.11 Emg1 6 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 High O70456 14-3-3 protein sigma OS=Mus musculus OX=10090 GN=Sfn PE=1 SV=2 0 7.757 13 4 9 1 248 27.7 4.78 1 3 2 3 1 3 2 3 464414.3125 4789306 3944390.5 4752478.5 1 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytosol;extracellular;membrane;nucleus protein binding Pf00244 55948 ENSMUSG00000047281.3 Sfn 4 Translocation of GLUT4 to the plasma membrane; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex p53 signaling pathway; Cell cycle; Aldosterone-regulated sodium reabsorption 0 High Q99N57 RAF proto-oncogene serine/threonine-protein kinase OS=Mus musculus OX=10090 GN=Raf1 PE=1 SV=2 0 15.618 10 7 9 4 648 72.9 9.16 1 7 1 8 425429.5625 508619.5 8232103.688 1 1 6 Acetyl [N-Term] cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00130, Pf02196, Pf07714, Pf14531" 110157 ENSMUSG00000000441.17 Raf1 6 CREB phosphorylation through the activation of Ras; Stimuli-sensing channels; Rap1 signalling; RAF activation; Interleukin-20 family signaling; MAP2K and MAPK activation; CD209 (DC-SIGN) signaling; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway Oxytocin signaling pathway; ErbB signaling pathway; FoxO signaling pathway; Acute myeloid leukemia; mTOR signaling pathway; T cell receptor signaling pathway; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; MicroRNAs in cancer; Progesterone-mediated oocyte maturation; Ras signaling pathway; Prolactin signaling pathway; VEGF signaling pathway; Focal adhesion; Jak-STAT signaling pathway; Insulin signaling pathway; Endometrial cancer; Long-term potentiation; Chemokine signaling pathway; Breast cancer; Melanoma; Signaling pathways regulating pluripotency of stem cells; Tuberculosis; Melanogenesis; Hepatitis B; Axon guidance; Non-small cell lung cancer; Sphingolipid signaling pathway; B cell receptor signaling pathway; Proteoglycans in cancer; Fc gamma R-mediated phagocytosis; Thyroid hormone signaling pathway; Neurotrophin signaling pathway; Long-term depression; cGMP-PKG signaling pathway; Rap1 signaling pathway; Pathways in cancer; Influenza A; Hepatitis C; Alcoholism; Pancreatic cancer; PI3K-Akt signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Renal cell carcinoma; GnRH signaling pathway; Natural killer cell mediated cytotoxicity; Gap junction; Glioma; Fc epsilon RI signaling pathway; EGFR tyrosine kinase inhibitor resistance; Central carbon metabolism in cancer; Choline metabolism in cancer; Estrogen signaling pathway; Colorectal cancer; Chronic myeloid leukemia; Serotonergic synapse; Prostate cancer; Endocrine resistance; Bladder cancer; Apoptosis 3 High Q91VA6 Polymerase delta-interacting protein 2 OS=Mus musculus OX=10090 GN=Poldip2 PE=1 SV=1 0 28.588 25 8 9 8 368 41.8 8.63 1 8 1 8 118176.2422 933379.7188 770734.5156 7402774.125 1 5 4 7 cell organization and biogenesis;regulation of biological process mitochondrion;nucleus DNA binding;protein binding "Pf04379, Pf08755" 67811 ENSMUSG00000001100.10 Poldip2 11 0 High Q9D0L4 AarF domain-containing protein kinase 1 OS=Mus musculus OX=10090 GN=Adck1 PE=1 SV=1 0 21.033 17 7 9 7 525 59.7 8.05 7 9 1076922.953 1326795.258 1611471.117 8785196.469 2 2 2 6 metabolic process extracellular;mitochondrion catalytic activity;enzyme regulator activity;nucleotide binding;receptor activity;signal transducer activity Pf03109 72113 ENSMUSG00000021044.14 Adck1 12 0 High E9QB02 "Methionine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Mars1 PE=1 SV=1" 0 14.738 6 6 9 6 910 102.3 6.92 2 2 5 2 2 5 336341.5078 646866.9375 829463.0703 5434705.438 3 2 3 6 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00043, Pf00133, Pf00458, Pf09334, Pf13410, Pf14497" 216443 ENSMUSG00000040354.14 Mars 10 0 High P16125 L-lactate dehydrogenase B chain OS=Mus musculus OX=10090 GN=Ldhb PE=1 SV=2 0 12.393 13 4 9 4 334 36.5 6.05 2 3 4 2 3 4 1652927.844 1615372.953 967694.8906 5175973.344 3 3 3 4 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00056, Pf02866" 16832 ENSMUSG00000030246.11 Ldhb 6 Pyruvate metabolism Pyruvate metabolism; Metabolic pathways; Cysteine and methionine metabolism; Glycolysis / Gluconeogenesis; Propanoate metabolism; Glucagon signaling pathway 0 High Q9R0E2 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Mus musculus OX=10090 GN=Plod1 PE=1 SV=1" 0 18.225 15 8 9 7 728 83.5 6.54 8 9 1054222.742 1760035.703 1276678.859 8479796.875 3 3 3 5 metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf03171 18822 ENSMUSG00000019055.15 Plod1 4 Collagen biosynthesis and modifying enzymes Lysine degradation 0 High Q61990 Poly(rC)-binding protein 2 OS=Mus musculus OX=10090 GN=Pcbp2 PE=1 SV=1 0 14.305 24 5 9 3 362 38.2 6.79 2 3 4 2 3 4 1431697.219 3068456.313 2979790.75 4867896 4 4 4 4 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding "Pf00013, Pf13014" 18521 ENSMUSG00000056851.13 Pcbp2 15 mRNA Splicing - Major Pathway 2 High P80315 T-complex protein 1 subunit delta OS=Mus musculus OX=10090 GN=Cct4 PE=1 SV=3 0 14.614 15 5 9 5 539 58 8.02 1 1 1 5 1 1 1 6 1176314.969 4824920.469 5118644.688 7458689.625 2 2 2 2 metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol nucleotide binding;protein binding;RNA binding Pf00118 12464 ENSMUSG00000007739.10 Cct4 11 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis 0 High P62843 40S ribosomal protein S15 OS=Mus musculus OX=10090 GN=Rps15 PE=1 SV=2 0 13.738 22 2 9 2 145 17 10.39 2 1 1 4 3 2 194552.5 775758.5156 534106.9063 960820.3281 1 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;transport membrane;ribosome protein binding;RNA binding;structural molecule activity Pf00203 20054 ENSMUSG00000063457.14 Rps15 10 Ribosome 0 High H7BX95 Serine/arginine-rich-splicing factor 1 OS=Mus musculus OX=10090 GN=Srsf1 PE=1 SV=1 0 8.449 16 4 9 4 253 28.3 10.08 2 3 2 2 4 3 3784796.125 9686925.375 8321045 4384348.75 3 3 3 2 metabolic process nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000018379.17; ENSMUSG00000098301.6 11; CHR_MG3829_PATCH 0 High Q99KV1 DnaJ homolog subfamily B member 11 OS=Mus musculus OX=10090 GN=Dnajb11 PE=1 SV=1 0 22.318 18 4 9 4 358 40.5 6.32 1 1 4 1 1 7 561008.0781 407388.1563 6804618.313 2 2 3 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen protein binding "Pf00226, Pf01556" 67838 ENSMUSG00000004460.16 Dnajb11 16 Protein processing in endoplasmic reticulum 0 High Q9D8L3 "Signal sequence receptor, delta OS=Mus musculus OX=10090 GN=Ssr4 PE=1 SV=1" 0 17.776 25 4 9 4 173 19 5.78 4 9 371458.3438 361519.125 18285490.75 1 1 3 endoplasmic reticulum;membrane Pf05404 20832 ENSMUSG00000002014.12 Ssr4 X 0 High Q99M87 "DnaJ homolog subfamily A member 3, mitochondrial OS=Mus musculus OX=10090 GN=Dnaja3 PE=1 SV=1" 0 24.118 19 5 9 5 480 52.4 9.22 2 2 5 2 2 5 160015.0586 2462588.906 2330112.109 7629401.438 2 4 4 4 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 83945 ENSMUSG00000004069.16 Dnaja3 16 Viral carcinogenesis 0 High P79568 Class Ib MHC antigen Qa-2 OS=Mus musculus OX=10090 GN=H2-Q6 PE=1 SV=1 0 13.348 13 4 9 1 326 37.4 6.24 2 1 4 2 1 6 2461978 1 cell surface;endoplasmic reticulum;Golgi;membrane protein binding;RNA binding "Pf00129, Pf07654, Pf08205" 110557 ENSMUSG00000073409.12 H2-Q6 17 Endocytosis; Herpes simplex infection; Allograft rejection; Epstein-Barr virus infection; Cell adhesion molecules (CAMs); HTLV-I infection; Phagosome; Graft-versus-host disease; Viral myocarditis; Antigen processing and presentation; Type I diabetes mellitus; Autoimmune thyroid disease; Viral carcinogenesis 0 High P04627 Serine/threonine-protein kinase A-Raf OS=Mus musculus OX=10090 GN=Araf PE=1 SV=2 0 18.59 10 6 9 3 604 67.5 9.11 1 6 1 8 278496.3125 3830936 1 3 cell differentiation;development;metabolic process;regulation of biological process;response to stimulus cytosol;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00069, Pf00130, Pf02196, Pf07714, Pf14531" 11836 ENSMUSG00000001127.12 Araf X Negative regulation of MAPK pathway; RAF activation; Interleukin-20 family signaling ErbB signaling pathway; FoxO signaling pathway; Acute myeloid leukemia; Regulation of actin cytoskeleton; Progesterone-mediated oocyte maturation; Insulin signaling pathway; Endometrial cancer; Long-term potentiation; Breast cancer; Melanoma; Non-small cell lung cancer; Proteoglycans in cancer; Long-term depression; Pathways in cancer; Hepatitis C; Alcoholism; Pancreatic cancer; Vascular smooth muscle contraction; Renal cell carcinoma; Natural killer cell mediated cytotoxicity; Glioma; EGFR tyrosine kinase inhibitor resistance; Colorectal cancer; Chronic myeloid leukemia; Serotonergic synapse; Prostate cancer; Endocrine resistance; Bladder cancer 0 High O88587 Catechol O-methyltransferase OS=Mus musculus OX=10090 GN=Comt PE=1 SV=2 0 24.505 42 8 9 8 265 29.5 5.83 8 9 569136.2109 1295715.797 1521563.688 21117326.81 3 3 2 4 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding "Pf01596, Pf12847, Pf13578, Pf13659" 12846 ENSMUSG00000000326.12; ENSMUSG00000098892.8 Comt 16; CHR_MG3833_MG4220_PATCH Enzymatic degradation of Dopamine by monoamine oxidase; Enzymatic degradation of dopamine by COMT; Methylation Steroid hormone biosynthesis; Dopaminergic synapse; Metabolic pathways; Tyrosine metabolism 0 High Q8C3X4 "Translation factor Guf1, mitochondrial OS=Mus musculus OX=10090 GN=Guf1 PE=1 SV=1" 0 25.621 15 7 9 7 651 72.4 8.76 7 9 1570064.672 4436271.688 2720639.406 11172972.06 3 4 5 6 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;nucleotide binding "Pf00009, Pf00071, Pf00679, Pf01926, Pf03144, Pf06421, Pf14492" 231279 ENSMUSG00000029208.16 Guf1 5 0 High O70503 Very-long-chain 3-oxoacyl-CoA reductase OS=Mus musculus OX=10090 GN=Hsd17b12 PE=1 SV=1 0 16.648 17 5 9 5 312 34.7 9.52 1 2 1 4 1 2 1 5 911752.3125 3107828.719 1926108.25 10440855.63 3 4 2 4 cell organization and biogenesis;metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity;protein binding "Pf00106, Pf02719, Pf08659, Pf13460" 56348 ENSMUSG00000027195.10 Hsd17b12 2 Synthesis of very long-chain fatty acyl-CoAs Fatty acid metabolism; Steroid hormone biosynthesis; Metabolic pathways; Fatty acid elongation; Biosynthesis of unsaturated fatty acids 0 High Q3UHT7 ERC protein 2 OS=Mus musculus OX=10090 GN=Erc2 PE=1 SV=1 0 10.949 5 5 9 1 977 113 7.09 4 3 1 5 3 1 359229.9688 382421.4688 302797.7813 1 1 1 transport cytoplasm;cytoskeleton;membrane protein binding;transporter activity "Pf01496, Pf04156, Pf10174, Pf13166" 238988 ENSMUSG00000040640.10 Erc2 14 0 High A0A087WR97 TAR DNA-binding protein 43 (Fragment) OS=Mus musculus OX=10090 GN=Tardbp PE=1 SV=1 0 7.631 27 3 9 3 243 26.7 7.77 3 1 2 4 2 3 783323.5 1548422.875 1286539.5 2085235.875 2 2 2 2 metabolic process;regulation of biological process RNA binding "Pf00076, Pf14259" ENSMUSG00000041459.15 4 0 High E9PWT4 "H-2 class I histocompatibility antigen, Q7 alpha chain OS=Mus musculus OX=10090 GN=H2-Q7 PE=3 SV=2" 0 14.039 14 4 9 1 310 35.2 6.13 2 1 4 2 1 6 260433.0156 333450 1359131.375 1 1 1 response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane protein binding;RNA binding "Pf00129, Pf07654, Pf08205" 15018 ENSMUSG00000060550.15 H2-Q7 17 0 High P62137 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Mus musculus OX=10090 GN=Ppp1ca PE=1 SV=1 0 15.774 16 5 9 5 330 37.5 6.33 2 2 5 2 2 5 574814.1875 5491932.656 5486636.031 41476323.78 1 3 2 4 cell division;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf00149 19045 ENSMUSG00000040385.6; ENSMUSG00000096994.2 Ppp1ca 19; CHR_MG153_PATCH DARPP-32 events; Signaling by GPCR Oxytocin signaling pathway; mRNA surveillance pathway; Herpes simplex infection; Regulation of actin cytoskeleton; Dopaminergic synapse; Focal adhesion; Insulin signaling pathway; Long-term potentiation; Amphetamine addiction; Hippo signaling pathway; Platelet activation; Insulin resistance; Oocyte meiosis; Proteoglycans in cancer; cGMP-PKG signaling pathway; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; Inflammatory mediator regulation of TRP channels 0 High Q61210 Rho guanine nucleotide exchange factor 1 OS=Mus musculus OX=10090 GN=Arhgef1 PE=1 SV=2 0 12.146 8 6 9 6 920 102.7 5.6 3 3 3 3 3 3 119528.7109 2097226.938 2004379.563 2386629.25 1 2 2 2 regulation of biological process cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf00621, Pf09128" 16801 ENSMUSG00000040940.18 Arhgef1 7 G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle Regulation of actin cytoskeleton; Platelet activation; Proteoglycans in cancer; Pathways in cancer; Vascular smooth muscle contraction 0 High Q9Z0M5 Lysosomal acid lipase/cholesteryl ester hydrolase OS=Mus musculus OX=10090 GN=Lipa PE=1 SV=2 0 11.425 15 5 9 5 397 45.3 8.07 1 5 1 8 120799.0938 178452.0938 587584.25 5024289.5 1 1 3 4 cell organization and biogenesis;cell proliferation;defense response;metabolic process;response to stimulus vacuole catalytic activity "Pf00561, Pf04083, Pf12695, Pf12697" 16889 ENSMUSG00000024781.15 Lipa 19 LDL clearance Steroid biosynthesis; Lysosome 0 High Q6PKB0 Fcgrt protein OS=Mus musculus OX=10090 GN=Fcgrt PE=1 SV=1 0 14.28 16 6 9 6 369 40.5 5.54 1 1 6 1 1 7 750241.4609 452099.8125 6470610.75 3 2 5 membrane protein binding;receptor activity;signal transducer activity "Pf00129, Pf07654" 14132 ENSMUSG00000003420.8 Fcgrt 7 0 High P09411 Phosphoglycerate kinase 1 OS=Mus musculus OX=10090 GN=Pgk1 PE=1 SV=4 0 16.248 18 5 9 5 417 44.5 7.9 1 2 1 5 1 2 1 5 640547.5938 1559950.469 1272936.375 4762387.938 2 3 3 4 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane catalytic activity;nucleotide binding Pf00162 18655 ENSMUSG00000062070.12 Pgk1 X Gluconeogenesis; Glycolysis Metabolic pathways; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism 0 High H3BKG0 Caveolin-1 OS=Mus musculus OX=10090 GN=Cav1 PE=1 SV=1 0 6.861 34 3 9 3 93 10.4 6.05 2 1 3 1 2 2 4 1 2390904.188 4354781.125 5847395.75 2589922.563 3 3 3 2 cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;Golgi;membrane enzyme regulator activity;protein binding;structural molecule activity Pf01146 ENSMUSG00000007655.16 6 0 High A0A087WQK5 "alpha-1,2-Mannosidase OS=Mus musculus OX=10090 GN=Edem3 PE=1 SV=1" 0 29.861 10 8 9 8 917 102.5 5.01 8 9 306605.7188 569357.5 496411.3438 7401403.375 1 1 1 7 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding "Pf01532, Pf02225" 66967 ENSMUSG00000043019.12 Edem3 1 0 High Q99LX0 Parkinson disease protein 7 homolog OS=Mus musculus OX=10090 GN=Park7 PE=1 SV=1 0 9.066 29 4 9 4 189 20 6.77 1 1 4 1 1 7 1321501 1754343.656 2219101.531 6657037.875 3 3 3 3 cell communication;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen antioxidant activity;catalytic activity;enzyme regulator activity;metal ion binding;protein binding;RNA binding "Pf01965, Pf13278" 57320 ENSMUSG00000028964.14 Park7 4 Parkinson's disease 0 High A0A087WS56 Fibronectin OS=Mus musculus OX=10090 GN=Fn1 PE=1 SV=1 0 13.532 4 5 9 5 2266 249.4 5.82 3 4 4 5 503565.2813 2622670.641 3719310 1 4 4 cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane enzyme regulator activity;metal ion binding;protein binding "Pf00039, Pf00040, Pf00041" 14268 ENSMUSG00000026193.15 Fn1 1 0 High D3YYN7 Sodium/potassium-transporting ATPase subunit alpha OS=Mus musculus OX=10090 GN=Atp1a2 PE=1 SV=1 0 31.949 12 9 9 5 947 103.5 5.44 9 9 73159.79688 403047.5156 271449.8281 6137376.75 1 2 2 7 cellular homeostasis;regulation of biological process;response to stimulus;transport membrane catalytic activity;metal ion binding;nucleotide binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" ENSMUSG00000007097.14 1 3 High Q8K3K7 1-acyl-sn-glycerol-3-phosphate acyltransferase beta OS=Mus musculus OX=10090 GN=Agpat2 PE=1 SV=1 0 24.105 34 7 9 7 278 31 8.88 7 9 122267.3281 139144.5156 789159.2969 27073796.5 1 1 2 7 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf01553 67512 ENSMUSG00000026922.13 Agpat2 2 Neutrophil degranulation; Synthesis of PA Phospholipase D signaling pathway; Fat digestion and absorption; Metabolic pathways; Glycerophospholipid metabolism; Glycerolipid metabolism 0 High A0A0R4J0I9 Prolow-density lipoprotein receptor-related protein 1 OS=Mus musculus OX=10090 GN=Lrp1 PE=1 SV=1 0 18.08 2 7 9 7 4545 504.4 5.36 1 1 7 1 1 7 215998.7383 935562.5703 910600.5313 7123897.313 3 4 5 6 cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus metal ion binding;protein binding;receptor activity;RNA binding "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670" 16971 ENSMUSG00000040249.15 Lrp1 10 Signaling by GPCR; Retinoid metabolism and transport; Scavenging of heme from plasma Alzheimer's disease; Malaria 0 High Q8BX10 "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Mus musculus OX=10090 GN=Pgam5 PE=1 SV=1" 0 8.195 15 6 9 6 288 32 9.04 4 1 2 2 4 1 2 2 3879624.727 1875245.219 2063284.313 2528611.688 6 4 4 4 cell death;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;enzyme regulator activity;protein binding;signal transducer activity Pf00300 72542 ENSMUSG00000029500.16 Pgam5 5 Receptor Mediated Mitophagy TNF signaling pathway 0 High Q61584 Fragile X mental retardation syndrome-related protein 1 OS=Mus musculus OX=10090 GN=Fxr1 PE=1 SV=2 0 6.645 5 3 9 2 677 76.2 6.98 3 3 2 3 3 3 165892.6875 773239.0625 706661.4375 1300030.375 1 1 1 2 cell differentiation;development;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding "Pf00013, Pf05641, Pf12235, Pf13014" 14359 ENSMUSG00000027680.15 Fxr1 3 RNA transport 0 High Q8JZU2 "Tricarboxylate transport protein, mitochondrial OS=Mus musculus OX=10090 GN=Slc25a1 PE=1 SV=1" 0 17.206 19 6 8 6 311 33.9 9.89 6 8 291938.0938 415155.5938 390277.8359 8445121.125 1 1 2 4 transport membrane;mitochondrion;nucleus transporter activity Pf00153 13358 ENSMUSG00000003528.14 Slc25a1 16 Gluconeogenesis; Fatty acyl-CoA biosynthesis 0 High Q9D6M3 Mitochondrial glutamate carrier 1 OS=Mus musculus OX=10090 GN=Slc25a22 PE=1 SV=1 0 22.365 27 6 8 6 323 34.6 9.09 6 8 5186855.813 4 transport membrane;mitochondrion transporter activity Pf00153 68267 ENSMUSG00000019082.18 Slc25a22 7 Organic anion transporters 0 High Q9CR14 E3 ubiquitin-protein ligase FANCL OS=Mus musculus OX=10090 GN=Fancl PE=1 SV=1 0 19.759 15 5 8 5 375 42.5 6.52 1 3 3 1 4 3 106314.5313 4455340.469 4451740.797 5741204.938 1 5 5 5 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;metal ion binding;protein binding "Pf09765, Pf11793, Pf12861" 67030 ENSMUSG00000004018.9 Fancl 11 Fanconi Anemia Pathway Ubiquitin mediated proteolysis; Fanconi anemia pathway 0 High Q3U186 "Probable arginine--tRNA ligase, mitochondrial OS=Mus musculus OX=10090 GN=Rars2 PE=1 SV=1" 0 22.458 17 8 8 8 578 65.3 8.02 8 8 625100.25 419146.6875 642435.2344 7802710.063 1 2 3 6 cell organization and biogenesis;metabolic process cytoplasm;mitochondrion;organelle lumen catalytic activity;nucleotide binding;RNA binding "Pf00750, Pf05746" 109093 ENSMUSG00000028292.14 Rars2 4 Aminoacyl-tRNA biosynthesis 0 High Q5SV64 Myosin-10 OS=Mus musculus OX=10090 GN=Myh10 PE=1 SV=1 0 14.983 5 8 8 7 2007 232.3 5.54 7 1 7 1 429875.0352 1414303.484 4963303.938 615172.0625 3 4 7 2 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;membrane;nucleus catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity "Pf00063, Pf00769, Pf01496, Pf01576, Pf02736, Pf02841, Pf04111, Pf05622, Pf05667, Pf05911, Pf06637, Pf07888, Pf09726, Pf09731, Pf12128, Pf13094, Pf13514" 77579 ENSMUSG00000020900.15 Myh10 11 0 High Q9DB91 Mediator of RNA polymerase II transcription subunit 29 OS=Mus musculus OX=10090 GN=Med29 PE=2 SV=1 0 13.246 19 3 8 3 199 21 6.29 2 1 2 3 2 3 221502.9844 2466238.438 2030523.375 2318060.313 1 4 4 4 metabolic process;regulation of biological process nucleus Pf11568 67224 ENSMUSG00000003444.8 Med29 7 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High Q9EQ20 "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Mus musculus OX=10090 GN=Aldh6a1 PE=1 SV=1" 0 7.436 8 4 8 4 535 57.9 8.07 1 1 3 2 1 1 4 2 1223669.156 1252627.5 2089876.313 1433610.438 3 2 3 2 cell differentiation;metabolic process mitochondrion catalytic activity;RNA binding Pf00171 104776 ENSMUSG00000021238.10 Aldh6a1 12 Branched-chain amino acid catabolism "Valine, leucine and isoleucine degradation; Metabolic pathways; beta-Alanine metabolism; Propanoate metabolism; Inositol phosphate metabolism; Carbon metabolism" 0 Low A0A0R4J1T2 E3 ubiquitin-protein ligase TTC3 (Fragment) OS=Mus musculus OX=10090 GN=Ttc3 PE=1 SV=1 0.057 0.873 1 1 8 1 776 88.8 7.68 1 8 241637.1563 441517.4375 235703.3594 338164.75 1 1 1 1 metabolic process;regulation of biological process cytosol;membrane;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00515, Pf13424, Pf13432" 22129 ENSMUSG00000040785.18 Ttc3 16 0 High Q8CG16 Complement C1r-A subcomponent OS=Mus musculus OX=10090 GN=C1ra PE=1 SV=1 0 10.408 9 5 8 5 707 80 5.66 3 4 1 3 4 1 2952409 2565232.938 2091947.75 6 5 5 defense response;metabolic process;regulation of biological process;response to stimulus catalytic activity;metal ion binding "Pf00084, Pf00089, Pf00431, Pf07645, Pf12662, Pf14670" 50909 ENSMUSG00000055172.10 C1ra 6 Regulation of Complement cascade; Classical antibody-mediated complement activation Staphylococcus aureus infection; Phagosome; Complement and coagulation cascades; Pertussis; Systemic lupus erythematosus 0 High P10922 Histone H1.0 OS=Mus musculus OX=10090 GN=H1-0 PE=2 SV=4 0 14.133 24 4 8 4 194 20.8 10.9 3 3 4 4 1355292.313 6418075.25 5729599.75 2 3 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis chromosome;cytoskeleton;Golgi;nucleus DNA binding;RNA binding Pf00538 14958 ENSMUSG00000096210.1 H1f0 15 Activation of DNA fragmentation factor; Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0 High Q91VN6 Probable ATP-dependent RNA helicase DDX41 OS=Mus musculus OX=10090 GN=Ddx41 PE=1 SV=2 0 11.777 11 5 8 5 622 69.8 6.7 3 3 1 1 3 3 1 1 1577518.281 2752305.688 3452807.25 1882788.656 3 3 3 3 cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf13307" 72935 ENSMUSG00000021494.8 Ddx41 13 STING mediated induction of host immune responses; Regulation of innate immune responses to cytosolic DNA 0 High Q99M73 "Keratin, type II cuticular Hb4 OS=Mus musculus OX=10090 GN=Krt84 PE=2 SV=2" 0 6.119 5 3 8 1 603 64.9 7.84 1 2 1 2 2 3 1 2 regulation of biological process cytoskeleton structural molecule activity Pf00038 16680 ENSMUSG00000044294.7 Krt84 15 Formation of the cornified envelope 0 Medium D3Z4R1 Probable ATP-dependent DNA helicase HFM1 OS=Mus musculus OX=10090 GN=Hfm1 PE=3 SV=2 0.034 1.152 0 1 8 1 1434 161.3 7.85 1 1 1 1 2 2 2 2 60492540 72643312 71518896 66321092 1 1 1 1 cell differentiation;metabolic process cytoplasm catalytic activity;DNA binding;nucleotide binding "Pf00270, Pf00271, Pf02889, Pf04851" 330149 ENSMUSG00000043410.16 Hfm1 5 0 High Q9D880 Mitochondrial import inner membrane translocase subunit TIM50 OS=Mus musculus OX=10090 GN=Timm50 PE=1 SV=1 0 11.732 9 3 8 3 353 39.8 8.13 2 1 3 2 1 5 342966.7891 1688102 1348523.063 10374601.94 2 2 2 3 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;protein binding Pf03031 66525 ENSMUSG00000003438.17 Timm50 7 0 High Q8JZQ2 AFG3-like protein 2 OS=Mus musculus OX=10090 GN=Afg3l2 PE=1 SV=1 0 21.392 9 7 8 7 802 89.5 8.6 7 8 331762.4219 308560.75 8167108.438 2 2 7 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00004, Pf01434, Pf05496, Pf06068, Pf06480, Pf07724, Pf07728, Pf13191, Pf13401" 69597 ENSMUSG00000024527.9 Afg3l2 18 Processing of SMDT1 0 High Q91VR5 ATP-dependent RNA helicase DDX1 OS=Mus musculus OX=10090 GN=Ddx1 PE=1 SV=1 0 7.096 6 3 8 3 740 82.4 7.21 3 2 2 1 3 2 2 1 1018504.719 1608693.25 1442945.188 1063351.031 2 2 2 2 development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf00622" 104721 ENSMUSG00000037149.9 Ddx1 12 0 High P58252 Elongation factor 2 OS=Mus musculus OX=10090 GN=Eef2 PE=1 SV=2 0 11.946 5 5 8 5 858 95.3 6.83 1 1 5 1 1 6 1271161.375 1958185.719 1756459.594 3684652.844 3 3 3 4 cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus;ribosome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" 13629 ENSMUSG00000034994.10 Eef2 10 Peptide chain elongation; Neutrophil degranulation; Protein methylation; Synthesis of diphthamide-EEF2 Oxytocin signaling pathway; AMPK signaling pathway 0 High P47962 60S ribosomal protein L5 OS=Mus musculus OX=10090 GN=Rpl5 PE=1 SV=3 0 14.337 12 3 8 3 297 34.4 9.77 1 1 2 2 1 1 3 3 707569.9844 3753277.563 3125698.344 3631891.938 3 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00861, Pf14204" 100503670 ENSMUSG00000058558.12 Rpl5 5 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q60749 "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Mus musculus OX=10090 GN=Khdrbs1 PE=1 SV=2" 0 4.685 7 3 8 3 443 48.3 8.72 1 2 2 2 1 3 2 2 678433.9063 2167185.313 1776087 1739543.875 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus protein binding;RNA binding "Pf00013, Pf13014" 20218 ENSMUSG00000028790.13 Khdrbs1 4 PTK6 Regulates Proteins Involved in RNA Processing 0 High E9Q616 AHNAK nucleoprotein (desmoyokin) OS=Mus musculus OX=10090 GN=Ahnak PE=1 SV=1 0 8.024 4 3 8 3 5656 603.9 6.3 1 2 3 1 3 4 526998.4375 1062199.875 1029784 3100712.875 2 2 2 3 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding;RNA binding;structural molecule activity 66395 ENSMUSG00000069833.12 Ahnak 19 0 High P43247 DNA mismatch repair protein Msh2 OS=Mus musculus OX=10090 GN=Msh2 PE=1 SV=1 0 17.791 7 6 8 6 935 104.1 5.96 1 6 1 7 69958.25781 381159.0625 585265.9375 3364938.594 1 2 3 5 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" 17685 ENSMUSG00000024151.13 Msh2 17 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Platinum drug resistance; Pathways in cancer; Colorectal cancer; Mismatch repair 0 High Q6NVF9 Cleavage and polyadenylation specificity factor subunit 6 OS=Mus musculus OX=10090 GN=Cpsf6 PE=1 SV=1 0 14.799 11 4 8 4 551 59.1 7.15 1 2 3 2 1 2 3 2 1184516.617 2314435.734 1957128.859 1225507.875 4 4 4 2 cell organization and biogenesis;metabolic process membrane;nucleus RNA binding "Pf00076, Pf14259" 432508 ENSMUSG00000055531.12 Cpsf6 10 mRNA surveillance pathway 0 High Q6AXB7 Fragile X mental retardation syndrome 1 homolog OS=Mus musculus OX=10090 GN=Fmr1 PE=1 SV=1 0 10.829 8 4 8 3 614 68.8 7.42 1 3 2 2 1 3 2 2 2402607.836 5292304.492 4668304.406 3829748.648 2 4 4 4 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus protein binding;RNA binding;translation regulator activity "Pf00013, Pf05641, Pf12235, Pf13014" 14265 ENSMUSG00000000838.17 Fmr1 X RNA transport 1 High Q9CQA5 Mediator of RNA polymerase II transcription subunit 4 OS=Mus musculus OX=10090 GN=Med4 PE=2 SV=1 0 22.327 20 4 8 4 270 29.8 5.05 1 2 4 1 2 5 1707314.406 2758642.563 2716189.75 2 3 2 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity Pf10018 67381 ENSMUSG00000022109.5 Med4 14 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway 0 High Q9CXI0 "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Mus musculus OX=10090 GN=Coq5 PE=1 SV=2" 0 23.422 24 5 8 5 327 37.3 7.49 5 8 91864.15625 382279.0625 634095.2813 7272667.125 1 1 2 3 metabolic process membrane;mitochondrion;organelle lumen catalytic activity "Pf01170, Pf01209, Pf08241, Pf08242, Pf12847, Pf13649, Pf13659, Pf13847" 52064 ENSMUSG00000041733.10 Coq5 5 Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways 0 High Q8K2W3 Thioredoxin domain-containing protein 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 0 25.548 11 8 8 8 948 105.9 7.88 8 8 481661.75 819483.125 407289.75 6966773.125 1 1 1 7 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity "Pf00085, Pf13905" 106200 ENSMUSG00000022498.16 Txndc11 16 0 High Q920D3 Mediator of RNA polymerase II transcription subunit 28 OS=Mus musculus OX=10090 GN=Med28 PE=1 SV=2 0 9.164 25 4 8 4 178 19.5 5.58 4 2 2 4 2 2 287144.8398 1356787.578 1075528.094 1874145.156 3 3 3 3 metabolic process;regulation of biological process cytoplasm;cytoskeleton;membrane;nucleus protein binding Pf11594 66999 ENSMUSG00000015804.14 Med28 5 0 High Q922Q8 Leucine-rich repeat-containing protein 59 OS=Mus musculus OX=10090 GN=Lrrc59 PE=1 SV=1 0 12.365 15 4 8 4 307 34.9 9.52 4 1 1 4 2 2 3749604.063 4404086 2298711.25 3357187.75 4 3 2 2 endoplasmic reticulum;membrane;nucleus protein binding;RNA binding "Pf12799, Pf13855" 98238 ENSMUSG00000020869.8 Lrrc59 11 0 Medium P56546 C-terminal-binding protein 2 OS=Mus musculus OX=10090 GN=Ctbp2 PE=1 SV=2 0.021 1.518 2 1 8 1 445 48.9 6.95 1 1 1 1 2 5 285488.7188 2089606.75 4179086.25 41639328 1 1 1 1 cell differentiation;metabolic process;regulation of biological process cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00389, Pf02826" 13017 ENSMUSG00000030970.16 Ctbp2 7 Wnt signaling pathway; Notch signaling pathway; Pathways in cancer; Chronic myeloid leukemia 0 High A0A1W2P7X3 Low molecular weight phosphotyrosine protein phosphatase OS=Mus musculus OX=10090 GN=Acp1 PE=1 SV=1 0 6.933 18 2 8 2 114 12.6 7.81 1 1 2 2 2 4 538915.0625 1816696.75 1658742.875 9087279 1 1 1 1 metabolic process catalytic activity Pf01451 ENSMUSG00000044573.15 12 0 High Q99M74 "Keratin, type II cuticular Hb2 OS=Mus musculus OX=10090 GN=Krt82 PE=1 SV=2" 0 3.056 2 2 8 2 516 57.1 6.25 1 2 1 1 1 2 1 4 32810250.81 38029839.5 32950946.38 38305185 2 2 2 2 structural molecule activity Pf00038 114566 ENSMUSG00000049548.8 Krt82 15 Formation of the cornified envelope 0 High F6T4M4 Serine/arginine repetitive matrix protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Srrm1 PE=1 SV=1 0 2.283 11 2 8 1 140 16.2 5.38 2 2 2 1 3 2 2 1 47359528 37751880 40300636 32919226 1 1 1 1 metabolic process Pf01480 ENSMUSG00000028809.16 4 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript 0 High A0A1L1STE4 Interleukin enhancer-binding factor 3 OS=Mus musculus OX=10090 GN=Ilf3 PE=1 SV=1 0 11.553 5 4 8 4 908 97.4 8.92 4 2 2 4 2 2 681045.9219 1485988.656 1404103.125 1338989.219 3 3 3 3 defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular;membrane;mitochondrion;nucleus DNA binding;protein binding;RNA binding "Pf00035, Pf07528, Pf14709" 16201 ENSMUSG00000032178.14 Ilf3 9 0 High Q9DB77 "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus OX=10090 GN=Uqcrc2 PE=1 SV=1" 0 21.551 16 6 8 6 453 48.2 9.25 1 6 1 7 974205.0547 1108726.789 888749.1563 10381578.31 3 4 4 6 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00675, Pf05193" 67003 ENSMUSG00000030884.12 Uqcrc2 7 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q8BFP9 "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Mus musculus OX=10090 GN=Pdk1 PE=1 SV=2" 0 23.596 19 7 8 6 434 49 8.19 7 8 1155356.469 8517908.063 2 5 cell proliferation;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf02518, Pf10436" 228026 ENSMUSG00000006494.11 Pdk1 2 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid Axon guidance; HIF-1 signaling pathway; Central carbon metabolism in cancer 1 High Q9CXU0 Mediator of RNA polymerase II transcription subunit 10 OS=Mus musculus OX=10090 GN=Med10 PE=1 SV=1 0 6.109 21 3 8 3 135 15.7 6.19 2 1 3 3 1 4 251118.0781 3008531.313 2107852.938 3730149.531 1 3 3 3 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus catalytic activity Pf09748 28077 ENSMUSG00000021598.8 Med10 13 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High P12787 "Cytochrome c oxidase subunit 5A, mitochondrial OS=Mus musculus OX=10090 GN=Cox5a PE=1 SV=2" 0 13.689 53 5 8 5 146 16.1 6.54 1 1 5 1 1 6 132480.4688 1380506 1316459.594 17670042.66 1 2 2 4 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;transporter activity Pf02284 12858 ENSMUSG00000000088.7 Cox5a 9 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q08857 Platelet glycoprotein 4 OS=Mus musculus OX=10090 GN=Cd36 PE=1 SV=2 0 19.647 16 6 8 6 472 52.7 8.35 6 8 1511649.313 299790.125 20462005.25 3 1 4 cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;endoplasmic reticulum;Golgi;membrane;mitochondrion protein binding;receptor activity;signal transducer activity Pf01130 12491 ENSMUSG00000002944.15 Cd36 5 Scavenging by Class B Receptors; Cross-presentation of particulate exogenous antigens (phagosomes); Regulation of TLR by endogenous ligand; Neutrophil degranulation; Platelet degranulation PPAR signaling pathway; Fat digestion and absorption; Insulin resistance; Phagosome; Adipocytokine signaling pathway; ECM-receptor interaction; AMPK signaling pathway; Hematopoietic cell lineage; Malaria 0 High P12242 Mitochondrial brown fat uncoupling protein 1 OS=Mus musculus OX=10090 GN=Ucp1 PE=1 SV=2 0 23.231 16 5 8 5 307 33.2 9.14 1 5 1 7 234369.9922 336794.4375 499109.4375 14471551.38 2 2 2 6 cell differentiation;regulation of biological process;response to stimulus;transport membrane;mitochondrion nucleotide binding;protein binding;transporter activity Pf00153 22227 ENSMUSG00000031710.4 Ucp1 8 The proton buffering model; The fatty acid cycling model PPAR signaling pathway; Huntington's disease 0 High Q8R2R1 Protein O-mannosyl-transferase 1 OS=Mus musculus OX=10090 GN=Pomt1 PE=1 SV=1 0 16.903 10 7 8 7 746 85.2 8.29 7 8 434411.3125 315125.875 8899755.125 1 1 5 cell organization and biogenesis;metabolic process;response to stimulus endoplasmic reticulum;membrane catalytic activity "Pf02366, Pf02815, Pf13231" 99011 ENSMUSG00000039254.16 Pomt1 2 O-linked glycosylation Other types of O-glycan biosynthesis 0 High Z4YKM2 "CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Mus musculus OX=10090 GN=Cisd3 PE=1 SV=1" 0 12.183 18 2 8 2 115 13.1 9.83 1 1 2 2 1 5 730222.2344 2489648 2647137.531 14868547.25 2 2 2 2 mitochondrion metal ion binding Pf09360 217149 ENSMUSG00000078695.8 Cisd3 11 0 High Q61646 Haptoglobin OS=Mus musculus OX=10090 GN=Hp PE=1 SV=1 0 5.777 7 3 8 3 347 38.7 6.29 3 2 2 4 2 2 4201729.125 4083729 3267857.938 3 3 3 defense response;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular;Golgi antioxidant activity;catalytic activity;protein binding "Pf00084, Pf00089" 15439 ENSMUSG00000031722.10 Hp 8 Neutrophil degranulation; Scavenging of heme from plasma 0 High Q3U3R4 Lipase maturation factor 1 OS=Mus musculus OX=10090 GN=Lmf1 PE=1 SV=1 0 25.659 14 6 8 6 574 65.8 9.29 6 8 232096.875 403099.7344 5359660.563 1 2 4 metabolic process;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf06762 76483 ENSMUSG00000002279.18 Lmf1 17 Assembly of active LPL and LIPC lipase complexes 0 High A0A1B0GQZ3 Stromal interaction molecule 1 (Fragment) OS=Mus musculus OX=10090 GN=Stim1 PE=1 SV=1 0 28.468 44 6 8 2 207 23.6 6.54 6 8 807229 1 regulation of biological process ENSMUSG00000030987.5 7 0 High D3YXK2 Scaffold attachment factor B1 OS=Mus musculus OX=10090 GN=Safb PE=1 SV=2 0 7.946 4 3 8 3 937 105 5.35 2 2 3 1 2 2 3 1 1262572.625 1627298.688 1597720.75 1476757.5 3 3 3 3 metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf02037, Pf13893, Pf14259" 224903 ENSMUSG00000071054.12 Safb 17 0 High P12815 Programmed cell death protein 6 OS=Mus musculus OX=10090 GN=Pdcd6 PE=1 SV=2 0 7.542 16 3 8 3 191 21.9 5.4 1 3 1 2 4 2 92959.89063 2943153.25 2299506.813 2810513.125 1 3 3 3 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus catalytic activity;metal ion binding;protein binding "Pf00036, Pf13405, Pf13499, Pf13833" 18570 ENSMUSG00000021576.5 Pdcd6 13 0 High Q9DBR0 A-kinase anchor protein 8 OS=Mus musculus OX=10090 GN=Akap8 PE=1 SV=1 0 13.109 14 4 8 4 687 76.2 5.14 1 3 3 1 4 3 1904477.375 2722319.75 3584245.594 3 4 4 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;Golgi;membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding Pf04988 56399 ENSMUSG00000024045.5 Akap8 17 0 High Q76MZ3 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus OX=10090 GN=Ppp2r1a PE=1 SV=3 0 19.225 13 6 8 6 589 65.3 5.11 2 1 5 2 1 5 346055.3047 1728752.641 1034195.859 4745327.875 3 4 3 5 cell organization and biogenesis;metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;membrane catalytic activity;enzyme regulator activity;protein binding "Pf02985, Pf13513, Pf13646" 51792 ENSMUSG00000007564.14 Ppp2r1a 17 "Loss of Nlp from mitotic centrosomes; RAF activation; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Spry regulation of FGF signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Activated TLR4 signalling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Signaling by GPCR; Regulation of TP53 Degradation; Negative regulation of MAPK pathway; RHO GTPases Activate Formins; Recruitment of NuMA to mitotic centrosomes; Cyclin A/B1/B2 associated events during G2/M transition; Interleukin-20 family signaling; Beta-catenin phosphorylation cascade; Recruitment of mitotic centrosome proteins and complexes; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of PLK1 Activity at G2/M Transition; CTLA4 inhibitory signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; ERKs are inactivated; DARPP-32 events; Initiation of Nuclear Envelope Reformation" mRNA surveillance pathway; Chagas disease (American trypanosomiasis); Dopaminergic synapse; Hippo signaling pathway; Oocyte meiosis; Sphingolipid signaling pathway; Long-term depression; TGF-beta signaling pathway; Hepatitis C; PI3K-Akt signaling pathway; AMPK signaling pathway; Tight junction; Adrenergic signaling in cardiomyocytes 0 High F7AEH4 40S ribosomal protein S12 OS=Mus musculus OX=10090 GN=Rps12 PE=1 SV=1 0 19.972 54 5 8 5 137 15.2 8.35 1 1 5 1 1 6 98700.92188 834167.8125 534697.4063 5566471.438 1 2 2 5 Met-loss+Acetyl [N-Term] metabolic process cytosol;membrane;ribosome RNA binding;structural molecule activity Pf01248 20042 ENSMUSG00000061983.7 Rps12 10 0 High P83887 Tubulin gamma-1 chain OS=Mus musculus OX=10090 GN=Tubg1 PE=1 SV=1 0 15.414 14 5 8 5 451 51.1 6.02 1 1 1 5 1 1 1 5 270085.5938 1426723 799110.6719 6073234.563 1 2 2 4 cell organization and biogenesis;regulation of biological process chromosome;cytoplasm;cytoskeleton;endosome catalytic activity;nucleotide binding;protein binding;structural molecule activity "Pf00091, Pf03953" 103733 ENSMUSG00000035198.9 Tubg1 11 Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes 0 High Q920A5 Retinoid-inducible serine carboxypeptidase OS=Mus musculus OX=10090 GN=Scpep1 PE=1 SV=2 0 13.267 8 3 8 3 452 50.9 5.66 2 3 3 2 3 3 311894.0625 836258.0625 3262185.609 2037643.148 1 2 3 3 metabolic process cytosol;extracellular catalytic activity Pf00450 74617 ENSMUSG00000000278.10 Scpep1 11 0 High P60867 40S ribosomal protein S20 OS=Mus musculus OX=10090 GN=Rps20 PE=1 SV=1 0 7.547 19 2 8 2 119 13.4 9.94 1 2 2 2 1 2 3 2 840988.5 2723346.25 2430740.813 4202351.25 1 2 2 2 metabolic process cytoplasm;membrane;ribosome RNA binding;structural molecule activity Pf00338 67427 ENSMUSG00000028234.6 Rps20 4 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High P11087 Collagen alpha-1(I) chain OS=Mus musculus OX=10090 GN=Col1a1 PE=1 SV=4 0 9.077 5 4 8 4 1453 137.9 5.85 1 2 3 1 3 4 669317.625 2925027.906 2882804.438 393526.6875 2 4 3 1 cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi metal ion binding;protein binding;structural molecule activity "Pf00093, Pf01391, Pf01410" 12842 ENSMUSG00000001506.10 Col1a1 11 Anchoring fibril formation; ECM proteoglycans; Cell surface interactions at the vascular wall; Platelet Aggregation (Plug Formation); Integrin cell surface interactions; Collagen degradation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Crosslinking of collagen fibrils; Collagen chain trimerization; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; MET activates PTK2 signaling; GPVI-mediated activation cascade; Non-integrin membrane-ECM interactions AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Platelet activation; Proteoglycans in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q9D7N9 Adipocyte plasma membrane-associated protein OS=Mus musculus OX=10090 GN=Apmap PE=1 SV=1 0 24.671 27 7 8 7 415 46.4 6.32 7 8 472386.4844 968079.7969 32327914.25 2 4 5 metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity "Pf03088, Pf08450" 71881 ENSMUSG00000033096.7 Apmap 2 0 High Q3V117 ATP-citrate synthase OS=Mus musculus OX=10090 GN=Acly PE=1 SV=1 0 5.477 2 3 7 3 1101 120.7 7.44 2 2 1 2 2 2 1 2 926657.8281 1287097.156 1057916.609 1820415.344 3 3 3 3 metabolic process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00285, Pf00549, Pf02629, Pf08442" 104112 ENSMUSG00000020917.17 Acly 11 0 High Q64012 RNA-binding protein Raly OS=Mus musculus OX=10090 GN=Raly PE=1 SV=3 0 4.781 6 2 7 2 312 33.2 8.84 1 2 2 2 1 2 2 2 139352.2969 919974 1149272.281 612801.4063 1 2 2 2 metabolic process;regulation of biological process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 19383 ENSMUSG00000027593.15 Raly 2 0 High P28798 Progranulin OS=Mus musculus OX=10090 GN=Grn PE=1 SV=2 0 15.66 10 3 7 3 589 63.4 6.8 2 1 2 3 1 3 4897237.625 3754249.375 3347248.125 5455302.5 2 2 2 2 cell proliferation;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;extracellular;mitochondrion;vacuole protein binding;RNA binding Pf00396 14824 Grn 11 0 High Q8R0X7 Sphingosine-1-phosphate lyase 1 OS=Mus musculus OX=10090 GN=Sgpl1 PE=1 SV=1 0 19.556 9 4 7 4 568 63.6 9.1 1 1 4 1 1 5 124532.0703 805020.2813 688025.9375 4502308.375 1 2 2 4 cell death;cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity "Pf00155, Pf00266, Pf00282, Pf01212, Pf05889" 20397 ENSMUSG00000020097.14 Sgpl1 10 Sphingolipid de novo biosynthesis Metabolic pathways; Sphingolipid signaling pathway; Sphingolipid metabolism 0 High D3Z041 Long-chain-fatty-acid--CoA ligase 1 OS=Mus musculus OX=10090 GN=Acsl1 PE=1 SV=1 0 10.572 7 5 7 4 699 78 7.47 1 1 5 1 1 5 1703829.125 2933661.844 3204316.594 4432780.875 1 4 4 4 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity Pf00501 ENSMUSG00000018796.13 8 1 High Q8R429 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Mus musculus OX=10090 GN=Atp2a1 PE=1 SV=1 0 10.041 4 5 7 1 994 109.4 5.22 1 5 1 6 270647.5313 1 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 11937 ENSMUSG00000030730.12 Atp2a1 7 Ion transport by P-type ATPases; Ion homeostasis; Reduction of cytosolic Ca++ levels Pancreatic secretion; cGMP-PKG signaling pathway; Calcium signaling pathway; Alzheimer's disease 0 High Q9D0M5 "Dynein light chain 2, cytoplasmic OS=Mus musculus OX=10090 GN=Dynll2 PE=1 SV=1" 0 7.614 21 3 7 3 89 10.3 7.37 1 1 3 2 1 4 6474523 6479919.438 6761532 6263912.688 1 3 2 3 cell organization and biogenesis;cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;motor activity;protein binding Pf01221 68097 ENSMUSG00000020483.14 Dynll2 11 Activation of BMF and translocation to mitochondria; COPI-mediated anterograde transport; Macroautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR); Intraflagellar transport; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; COPI-independent Golgi-to-ER retrograde traffic; RHO GTPases Activate Formins; MHC class II antigen presentation Vasopressin-regulated water reabsorption 0 High G5E881 "Phosphatidate cytidylyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Tamm41 PE=1 SV=1" 0 11.28 14 4 7 4 337 37.9 9.11 1 1 4 1 1 5 763218.4375 2222967.75 1239772.5 5935516.844 2 4 3 4 Met-loss+Acetyl [N-Term] metabolic process membrane;mitochondrion catalytic activity Pf09139 68971 ENSMUSG00000030316.13 Tamm41 6 0 High Q9DC70 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs7 PE=1 SV=1" 0 17.683 30 5 7 5 224 24.7 9.92 1 1 5 1 1 5 281150.9766 882094.5625 558183.1563 11088599.03 2 2 2 5 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding Pf01058 75406 ENSMUSG00000020153.14 Ndufs7 10 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q9Z204 Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Mus musculus OX=10090 GN=Hnrnpc PE=1 SV=1 0 7.856 7 2 7 2 313 34.4 5.05 1 2 2 2 1 2 2 2 553050.0469 2763605.75 2116524.563 1714465.125 2 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 15381 ENSMUSG00000060373.14 Hnrnpc 14 mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins Spliceosome 0 High Q8BL97 Serine/arginine-rich splicing factor 7 OS=Mus musculus OX=10090 GN=Srsf7 PE=1 SV=1 0 7.552 16 3 7 3 267 30.8 11.9 1 3 2 1 1 3 2 1 1227849.375 3899788 2592346.063 1089974.25 2 3 2 1 metabolic process;regulation of biological process;transport cytoplasm;nucleus metal ion binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 225027 Srsf7 17 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High Q8VHI3 GDP-fucose protein O-fucosyltransferase 2 OS=Mus musculus OX=10090 GN=Pofut2 PE=1 SV=1 0 18.536 18 6 7 6 429 49.4 6.48 6 7 153784.1719 6075314.156 1 6 metabolic process;regulation of biological process endoplasmic reticulum;Golgi catalytic activity Pf10250 80294 ENSMUSG00000020260.9 Pofut2 10 O-glycosylation of TSR domain-containing proteins Other types of O-glycan biosynthesis 0 High A0A1L1SQX6 Noelin-2 OS=Mus musculus OX=10090 GN=Olfm2 PE=4 SV=1 0 15.417 14 6 7 6 456 51.6 8.13 6 7 255945.8281 6671089.688 1 4 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;extracellular;membrane;nucleus protein binding "Pf02191, Pf12308, Pf14817" 244723 ENSMUSG00000032172.8 Olfm2 9 0 High A0A2R8W6R3 E3 ubiquitin-protein ligase RBX1 OS=Mus musculus OX=10090 GN=Rbx1 PE=1 SV=1 0 18.822 24 2 7 2 83 9.1 5.8 1 2 2 2 2 3 3651652.25 3995331 4233267.375 2 2 2 Met-loss+Acetyl [N-Term] 0 High Q9CQZ6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Mus musculus OX=10090 GN=Ndufb3 PE=1 SV=1 0 6.408 17 2 7 2 104 11.7 9.04 2 1 2 2 1 4 234687.4844 1521366.406 1084007.063 6689743.75 1 2 2 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion Pf08122 66495 ENSMUSG00000026032.8 Ndufb3 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q9Z2E9 Seipin OS=Mus musculus OX=10090 GN=Bscl2 PE=1 SV=2 0 8.893 10 1 7 1 383 43.1 6.14 1 1 1 1 1 2 2 2 914702.25 1603725.625 941169.8125 712449.375 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process endoplasmic reticulum;membrane Pf06775 14705 ENSMUSG00000071657.12 Bscl2 19 0 High Q91VS7 Microsomal glutathione S-transferase 1 OS=Mus musculus OX=10090 GN=Mgst1 PE=1 SV=3 0 5.657 8 1 7 1 155 17.5 9.66 1 1 1 2 2 3 691681.375 2321976.25 2934870.75 9975011 1 1 1 1 cell organization and biogenesis;metabolic process;response to stimulus endoplasmic reticulum;membrane;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding Pf01124 56615 ENSMUSG00000008540.11 Mgst1 6 Glutathione conjugation; Aflatoxin activation and detoxification; Neutrophil degranulation Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 High Q9QZE5 Coatomer subunit gamma-1 OS=Mus musculus OX=10090 GN=Copg1 PE=1 SV=1 0 9.223 6 4 7 4 874 97.5 5.35 1 1 4 1 1 5 284383.9063 450873.0156 2277304.469 1 2 3 cellular component movement;transport cytoplasm;cytosol;Golgi;membrane structural molecule activity "Pf01602, Pf08752" 54161 ENSMUSG00000030058.17 Copg; Copg1 6 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q3TZZ7 Extended synaptotagmin-2 OS=Mus musculus OX=10090 GN=Esyt2 PE=1 SV=1 0 15.704 14 7 7 7 845 94.1 7.75 7 7 97604.13281 376670.3672 3138158.625 1 3 4 transport endoplasmic reticulum;membrane metal ion binding;protein binding Pf00168 52635 ENSMUSG00000021171.7 Esyt2 12 Glycosphingolipid metabolism 0 High Q921K2 Poly [ADP-ribose] polymerase OS=Mus musculus OX=10090 GN=Parp1 PE=1 SV=1 0 12.032 7 5 7 5 1014 112.7 8.95 1 1 5 1 1 5 544410.2969 2518003.156 2844718.469 1054799.867 3 6 6 4 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063" 11545 ENSMUSG00000026496.11 Parp1 1 HDR through MMEJ (alt-NHEJ); DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Dual Incision in GG-NER; POLB-Dependent Long Patch Base Excision Repair; SUMOylation of DNA damage response and repair proteins NF-kappa B signaling pathway; Base excision repair; Apoptosis 0 High Q9DBB9 Carboxypeptidase N subunit 2 OS=Mus musculus OX=10090 GN=Cpn2 PE=1 SV=2 0 21.665 14 6 7 6 547 60.4 5.88 6 7 221883.3438 568105.6875 7860971.063 1 1 6 extracellular protein binding "Pf12799, Pf13306, Pf13855" 71756 ENSMUSG00000023176.8 Cpn2 16 Regulation of Complement cascade 0 High Q9CQQ4 Gem-associated protein 2 OS=Mus musculus OX=10090 GN=Gemin2 PE=2 SV=1 0 10.67 16 3 7 3 269 30.4 5.53 2 1 3 3 1 3 1639639.172 663872.3906 1992706.469 3 2 3 Met-loss+Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex Pf04938 66603 ENSMUSG00000060121.15 Gemin2; Sip1 12 snRNP Assembly RNA transport 0 High Q99JR8 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Mus musculus OX=10090 GN=Smarcd2 PE=1 SV=2 0 9.461 11 4 7 2 531 59 9.64 4 2 1 4 2 1 415243.375 2592898.969 2404624.438 2524467.406 2 3 3 2 cell organization and biogenesis;metabolic process;regulation of biological process nucleus DNA binding;protein binding Pf02201 83796 ENSMUSG00000078619.10 Smarcd2 11 RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 1 High H7BX01 "Dynamin-like 120 kDa protein, mitochondrial OS=Mus musculus OX=10090 GN=Opa1 PE=1 SV=1" 0 23.279 8 6 7 6 978 113.2 7.33 1 6 1 6 612100.4844 481157.9688 354029.625 2111839.094 2 1 1 3 cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00350, Pf01926" 74143 ENSMUSG00000038084.16 Opa1 16 0 Medium Q6AXE3 ATP-binding cassette sub-family A member 3 OS=Mus musculus OX=10090 GN=Abca3 PE=1 SV=1 0.045 1.068 1 1 7 1 1449 163.4 7.83 1 1 1 4 1 2 71807377.69 114794177.9 71193979.5 68203382 1 1 1 1 transport membrane catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf03193, Pf12698, Pf13304, Pf13476" 27410 ENSMUSG00000024130.15 Abca3 17 ABC transporters 0 High P97868 E3 ubiquitin-protein ligase RBBP6 OS=Mus musculus OX=10090 GN=Rbbp6 PE=1 SV=5 0 4.242 2 3 7 3 1790 199.5 9.63 3 2 1 1 3 2 1 1 2808108.781 1442498.875 1700127.625 180012.5938 3 2 2 1 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;cytoskeleton;nucleus catalytic activity;metal ion binding;protein binding;RNA binding "Pf00097, Pf00098, Pf08783, Pf13639, Pf13696, Pf13920, Pf13923, Pf14634, Pf15227" 19647 ENSMUSG00000030779.15 Rbbp6 7 Antigen processing: Ubiquitination & Proteasome degradation 0 Medium P18529 Ig heavy chain V region 5-76 OS=Mus musculus OX=10090 PE=1 SV=1 0.027 1.367 6 1 7 1 117 13 8.91 1 1 1 1 1 2 2 2 1200410.25 1940790.75 1801135.125 2465496.5 1 1 1 1 Pf07686 0 High Q64521 "Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Gpd2 PE=1 SV=2" 0 19.296 8 5 7 5 727 80.9 6.61 2 5 2 5 1263889.5 2787534.031 2196224.531 5122821.125 3 4 4 4 metabolic process membrane;mitochondrion catalytic activity;metal ion binding "Pf00890, Pf01266, Pf03486, Pf07992, Pf12831, Pf13499" 14571 ENSMUSG00000026827.12 Gpd2 2 Triglyceride catabolism; Synthesis of PA Glycerophospholipid metabolism 0 High Q8K0L9 Zinc finger and BTB domain-containing protein 20 OS=Mus musculus OX=10090 GN=Zbtb20 PE=1 SV=1 0 7.871 6 3 7 3 741 81 6.55 3 3 3 4 156225.1719 1010737.141 1605664.047 444422.0625 1 3 3 2 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding "Pf00096, Pf00651, Pf13465" 56490 ENSMUSG00000022708.16 Zbtb20 16 0 High Q6ZWQ7 Signal peptidase complex subunit 3 OS=Mus musculus OX=10090 GN=Spcs3 PE=1 SV=1 0 18.149 19 4 7 4 180 20.3 8.62 4 7 17734738.5 4 metabolic process endoplasmic reticulum;membrane catalytic activity Pf04573 76687 ENSMUSG00000054408.9 Spcs3 8 "Synthesis, secretion, and deacylation of Ghrelin" Protein export 0 High Q9CR68 "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Mus musculus OX=10090 GN=Uqcrfs1 PE=1 SV=1" 0 14.667 14 5 7 5 274 29.3 8.7 1 5 1 6 137932.8281 326349.7578 340751.2188 6691622.5 2 2 2 4 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;protein binding;transporter activity "Pf00355, Pf02921, Pf09165" 66694 ENSMUSG00000038462.3 Uqcrfs1 13 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High A0A1L1SUN1 60S ribosomal protein L29 (Fragment) OS=Mus musculus OX=10090 GN=Rpl29 PE=1 SV=1 0 4.656 20 2 7 2 94 10.5 11.72 1 2 2 1 1 3 2 1 1421663.625 6083948 4465200.75 6672853.5 2 2 2 2 metabolic process ribosome structural molecule activity ENSMUSG00000048758.14 9 0 High Q3TGY1 Serine/Arginine-related protein 53 OS=Mus musculus OX=10090 GN=Rsrc1 PE=1 SV=1 0 9.552 15 3 7 3 292 33.5 10.35 1 2 1 2 1 2 2 2 631906.2188 1503839.125 1481900.531 769827.9844 2 2 2 2 metabolic process;response to stimulus;transport cytoplasm;nucleus protein binding 66880 ENSMUSG00000034544.17 Rsrc1 3 0 High Q8QZY9 Splicing factor 3B subunit 4 OS=Mus musculus OX=10090 GN=Sf3b4 PE=1 SV=1 0 3.424 3 1 7 1 424 44.3 8.56 1 1 1 1 2 2 2 1 406157.9375 547242.75 558928.8125 395892.0625 1 1 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex RNA binding "Pf00076, Pf13893, Pf14259" 107701 ENSMUSG00000068856.3 Sf3b4 3 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9CXW4 60S ribosomal protein L11 OS=Mus musculus OX=10090 GN=Rpl11 PE=1 SV=4 0 6.296 13 2 7 2 178 20.2 9.6 1 1 1 1 1 2 2 2 4772698.5 17974578 14531865 21900455 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;membrane;nucleus;ribosome protein binding;RNA binding;structural molecule activity "Pf00281, Pf00673" 67025 ENSMUSG00000059291.15 Rpl11 4 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High P13516 Acyl-CoA desaturase 1 OS=Mus musculus OX=10090 GN=Scd1 PE=1 SV=2 0 12.468 7 3 7 3 355 41 9.07 2 3 2 5 101884.7813 1347431.719 2042307.125 10032832.13 1 3 3 3 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf00487 20249 ENSMUSG00000037071.2 Scd1 19 Fatty acyl-CoA biosynthesis PPAR signaling pathway; Fatty acid metabolism; AMPK signaling pathway; Biosynthesis of unsaturated fatty acids 0 High Q8R3Q0 Store-operated calcium entry-associated regulatory factor OS=Mus musculus OX=10090 GN=Saraf PE=1 SV=2 0 10.18 15 3 7 3 334 35.8 8.19 3 2 5 2 466406.0938 1 regulation of biological process;transport endoplasmic reticulum;membrane Pf06682 67887 Tmem66; Saraf 8 0 High Q5SWW4 Mediator of RNA polymerase II transcription subunit 13 OS=Mus musculus OX=10090 GN=Med13 PE=1 SV=1 0 9.924 2 4 7 3 2171 238.4 5.67 4 1 2 4 1 2 126033.8984 259155.4375 536805.6094 785879.7188 1 1 2 2 metabolic process;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity "Pf06333, Pf11597" 327987 ENSMUSG00000034297.14 Med13 11 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway 0 High Q8C2Q3 RNA-binding protein 14 OS=Mus musculus OX=10090 GN=Rbm14 PE=1 SV=1 0 10.966 7 4 7 4 669 69.4 9.67 2 4 1 2 4 1 196850.5156 2789587.594 3139060.094 776649.1563 2 4 4 2 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus RNA binding "Pf00076, Pf13893, Pf14259" 56275 ENSMUSG00000006456.10 Rbm14 19 RUNX2 regulates bone development 0 High A0A1D5RM23 Cleavage and polyadenylation specificity factor subunit 5 OS=Mus musculus OX=10090 GN=Nudt21 PE=1 SV=1 0 6.086 12 2 7 2 218 25.2 9.36 1 2 1 1 2 2 2 1 406172.125 1221367.25 896114.625 1012532.188 1 1 1 1 metabolic process catalytic activity;RNA binding Pf13869 ENSMUSG00000031754.10 8 0 High P04223 "H-2 class I histocompatibility antigen, K-K alpha chain OS=Mus musculus OX=10090 GN=H2-K1 PE=1 SV=1" 0 8.623 13 4 7 2 369 41.6 7.03 1 1 4 1 1 5 311978.1563 1 defense response;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;membrane protein binding;RNA binding "Pf00129, Pf06623, Pf07654" 14972 H2-K1 17 0 High Q9D7W5 Mediator of RNA polymerase II transcription subunit 8 OS=Mus musculus OX=10090 GN=Med8 PE=1 SV=1 0 4.406 5 1 7 1 268 29.2 6.95 1 1 1 1 1 2 2 2 679296.5625 1412701 1302706.375 1514773.5 1 1 1 1 metabolic process;regulation of biological process nucleus protein binding Pf10232 80509 ENSMUSG00000006392.16 Med8 4 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Herpes simplex infection 0 High K3W4Q8 Basigin OS=Mus musculus OX=10090 GN=Bsg PE=1 SV=1 0 17.704 30 5 7 5 218 24.1 5.36 1 5 1 6 1836602 2832153.625 2178712.375 15760536.88 1 2 2 4 cell organization and biogenesis membrane;mitochondrion protein binding "Pf00047, Pf07679, Pf13927" 12215 ENSMUSG00000023175.15 Bsg 10 0 High E9QLQ3 Phosphodiesterase OS=Mus musculus OX=10090 GN=Pde3b PE=1 SV=1 0 17.757 6 4 7 4 1099 122 5.74 1 1 4 1 1 5 336709.2031 818940.3438 764324.125 2497886.719 2 2 2 3 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00233 18576 ENSMUSG00000030671.9 Pde3b 7 PDE3B signalling; G alpha (s) signalling events; cGMP effects Morphine addiction; Progesterone-mediated oocyte maturation; Regulation of lipolysis in adipocytes; Insulin signaling pathway; Purine metabolism; cGMP-PKG signaling pathway; cAMP signaling pathway; Renin secretion; Glucagon signaling pathway 0 High Q00623 Apolipoprotein A-I OS=Mus musculus OX=10090 GN=Apoa1 PE=1 SV=2 0 6.57 14 4 7 4 264 30.6 5.73 1 1 3 2 1 1 3 2 1125835.672 1464209.5 4000955.438 2532464.656 3 2 3 3 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytosol;extracellular;nucleus enzyme regulator activity;protein binding;transporter activity Pf01442 11806 ENSMUSG00000032083.8 Apoa1 9 Post-translational protein phosphorylation; Scavenging by Class A Receptors; Chylomicron assembly; Signaling by GPCR; ABC transporters in lipid homeostasis; HDL clearance; Chylomicron remodeling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging by Class B Receptors; HDL assembly; Retinoid metabolism and transport; Platelet degranulation ; HDL remodeling; Scavenging of heme from plasma Vitamin digestion and absorption; PPAR signaling pathway; African trypanosomiasis; Fat digestion and absorption 0 High P47758 Signal recognition particle receptor subunit beta OS=Mus musculus OX=10090 GN=Srprb PE=1 SV=1 0 22.611 24 5 7 5 269 29.6 9.28 5 7 62282.67188 195521.1563 214809.9063 7655394.875 1 1 1 4 regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane nucleotide binding;protein binding "Pf00009, Pf00025, Pf01926, Pf09439" 20818 ENSMUSG00000032553.14 Srprb 9 Protein export 0 High Q6ZQI3 Malectin OS=Mus musculus OX=10090 GN=Mlec PE=1 SV=2 0 11.194 16 4 6 4 291 32.3 6.05 4 6 1375136.406 280481.7813 5071163.938 2 1 4 metabolic process endoplasmic reticulum;membrane protein binding Pf11721 109154 ENSMUSG00000048578.11 Mlec 5 N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Neutrophil degranulation 0 High A0A498WGK2 Asparaginyl-tRNA synthetase OS=Mus musculus OX=10090 GN=Nars PE=4 SV=1 0 4.514 5 3 6 3 558 64.2 5.86 1 1 3 1 1 4 660278.0625 462677.25 2374086.125 2 1 2 0 High Q9CQW2 ADP-ribosylation factor-like protein 8B OS=Mus musculus OX=10090 GN=Arl8b PE=1 SV=1 0 11.537 22 3 6 3 186 21.5 8.43 3 6 700620.8281 647976.1016 4340135 2 2 2 cell division;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;endosome;membrane;vacuole catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439" 67166 ENSMUSG00000030105.8 Arl8b 6 0 High G3UVV4 Hexokinase-1 OS=Mus musculus OX=10090 GN=Hk1 PE=1 SV=1 0 17.447 7 6 6 3 917 101.8 6.67 6 6 108111.1172 90255.19531 2400694.813 1 1 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00349, Pf03727" 15275 ENSMUSG00000037012.18 Hk1 10 0 High P15105 Glutamine synthetase OS=Mus musculus OX=10090 GN=Glul PE=1 SV=6 0 7.917 14 3 6 3 373 42.1 7.08 1 2 2 1 1 2 2 1 723325.25 769863.4375 515447 684597.0625 1 1 1 1 cell communication;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00120, Pf03951" 14645 ENSMUSG00000026473.15 Glul 1 Astrocytic Glutamate-Glutamine Uptake And Metabolism; Amino acid synthesis and interconversion (transamination) "GABAergic synapse; Metabolic pathways; Nitrogen metabolism; Biosynthesis of amino acids; Glutamatergic synapse; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis; Glyoxylate and dicarboxylate metabolism" 0 High Q8R0Y8 Mitochondrial coenzyme A transporter SLC25A42 OS=Mus musculus OX=10090 GN=Slc25a42 PE=1 SV=1 0 22.392 25 5 6 5 318 35.2 10.05 5 6 93907.59375 907847.0313 5956052.313 1 3 4 transport membrane;mitochondrion;nucleus catalytic activity;transporter activity Pf00153 73095 ENSMUSG00000002346.16 Slc25a42 8 0 High E9QAT4 Protein transport protein Sec16A OS=Mus musculus OX=10090 GN=Sec16a PE=1 SV=1 0 10.055 3 5 6 5 2357 254 5.81 1 5 1 5 136897.2969 440141.7344 523159.2969 2363306.813 1 2 2 4 cell organization and biogenesis;transport cytosol;endoplasmic reticulum;Golgi;membrane catalytic activity "Pf10697, Pf12931, Pf12932" 227648 ENSMUSG00000026924.17 Sec16a 2 COPII (Coat Protein 2) Mediated Vesicle Transport 0 High Q9QWR8 Alpha-N-acetylgalactosaminidase OS=Mus musculus OX=10090 GN=Naga PE=1 SV=2 0 5.573 4 2 6 2 415 47.2 6.44 1 2 1 1 3 2 195792.9688 826392.6875 2548633.688 2349552.109 1 1 2 2 metabolic process cytoplasm;vacuole catalytic activity;protein binding Pf02065 17939 ENSMUSG00000022453.7 Naga 15 Glycosphingolipid biosynthesis - globo and isoglobo series; Lysosome 0 High A2BDX2 Dolichol-phosphate mannosyltransferase subunit 1 OS=Mus musculus OX=10090 GN=Dpm1 PE=1 SV=1 0 16.509 19 4 6 4 208 23.4 9.31 4 6 296451.625 203545.8594 6019689.063 2 1 4 metabolic process endoplasmic reticulum;membrane;nucleus catalytic activity "Pf00535, Pf10111, Pf13641, Pf13704, Pf13712" 13480 ENSMUSG00000078919.10 Dpm1 2 0 High Q8BX02 KN motif and ankyrin repeat domain-containing protein 2 OS=Mus musculus OX=10090 GN=Kank2 PE=1 SV=1 0 21.359 8 5 6 5 843 90.2 5.55 1 5 1 5 23852529.75 30259166.59 22652802.09 30344903.94 2 2 2 4 cell death;metabolic process;regulation of biological process cytoplasm;mitochondrion protein binding "Pf00023, Pf12075, Pf12796, Pf13606, Pf13637, Pf13857" 235041 ENSMUSG00000032194.9 Kank2 9 0 High Q8BIJ6 "Isoleucine--tRNA ligase, mitochondrial OS=Mus musculus OX=10090 GN=Iars2 PE=1 SV=1" 0 10.47 5 4 6 4 1012 112.7 6.81 1 1 4 1 1 4 146966.0313 502790.9063 452941.8281 1745378.906 2 2 2 4 metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;RNA binding "Pf00133, Pf01921, Pf06827, Pf08264, Pf09334, Pf13603" 381314 ENSMUSG00000026618.11 Iars2 1 Aminoacyl-tRNA biosynthesis 0 High A0A140LIZ5 26S proteasome regulatory subunit 6B OS=Mus musculus OX=10090 GN=Psmc4 PE=1 SV=1 0 20.604 25 6 6 6 387 43.5 5.26 6 6 655321.25 760049.7188 5140916.063 2 2 5 Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;nucleotide binding;RNA binding "Pf00004, Pf00006, Pf00910, Pf01057, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191" ENSMUSG00000030603.16 7 0 High O35326 Serine/arginine-rich splicing factor 5 OS=Mus musculus OX=10090 GN=Srsf5 PE=1 SV=2 0 8.769 11 3 6 2 269 30.9 11.56 2 2 2 2 2 2 837655.5938 2563751.25 1766125.75 982574.5625 2 2 2 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 20384 ENSMUSG00000021134.17 Srsf5 12 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 High Q8BJ56 Patatin-like phospholipase domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pnpla2 PE=1 SV=1 0 12.216 14 5 6 5 486 53.6 6.46 1 5 1 5 186585.7813 396171.6563 345565.1406 3031827.031 2 3 2 4 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane catalytic activity;protein binding Pf01734 66853 ENSMUSG00000025509.15 Pnpla2 7 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Acyl chain remodeling of DAG and TAG Regulation of lipolysis in adipocytes; Metabolic pathways; Glycerolipid metabolism 0 High O89023 Tripeptidyl-peptidase 1 OS=Mus musculus OX=10090 GN=Tpp1 PE=1 SV=2 0 14.404 6 2 6 2 562 61.3 6.57 2 2 1 2 3 1 1970457.406 3105233.313 1866515.938 2 2 1 cell differentiation;cell organization and biogenesis;metabolic process mitochondrion;vacuole catalytic activity;metal ion binding;protein binding "Pf00082, Pf09286" 12751 ENSMUSG00000030894.5 Tpp1 7 Lysosome 0 High P60335 Poly(rC)-binding protein 1 OS=Mus musculus OX=10090 GN=Pcbp1 PE=1 SV=1 0 8.914 12 3 6 1 356 37.5 7.09 1 2 3 1 2 3 861880.5625 2970959 3177487.5 2936697.25 1 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus DNA binding;protein binding;RNA binding;translation regulator activity "Pf00013, Pf13014" 23983 ENSMUSG00000051695.6 Pcbp1 6 mRNA Splicing - Major Pathway Spliceosome 0 High P10639 Thioredoxin OS=Mus musculus OX=10090 GN=Txn PE=1 SV=3 0 7.89 21 2 6 2 105 11.7 4.92 1 1 1 2 1 1 1 3 3611330.875 2118040.5 1872223.875 6419915.75 2 1 1 2 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;extracellular;mitochondrion;nucleus antioxidant activity;catalytic activity;protein binding;RNA binding "Pf00085, Pf13098, Pf13899, Pf13905" 22166 ENSMUSG00000028367.5 Txn1 4 Interconversion of nucleotide di- and triphosphates; Protein repair; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Oxidative Stress Induced Senescence; The NLRP3 inflammasome NOD-like receptor signaling pathway 0 High A0A0J9YU92 F-box only protein 21 (Fragment) OS=Mus musculus OX=10090 GN=Fbxo21 PE=1 SV=1 0 10.877 7 2 6 2 504 59.1 6.23 1 1 2 1 2 3 1202089.375 1136193.625 1947278.625 1 1 1 DNA binding;protein binding "Pf08755, Pf13369" ENSMUSG00000032898.9 5 0 High Q61087 Laminin subunit beta-3 OS=Mus musculus OX=10090 GN=Lamb3 PE=1 SV=2 0 14.845 8 6 6 6 1168 128.8 7.47 6 6 1245430.625 409436.375 4910097.516 1 1 5 cell differentiation extracellular protein binding "Pf00053, Pf00055" 16780 ENSMUSG00000026639.18 Lamb3 1 Anchoring fibril formation; Laminin interactions; Degradation of the extracellular matrix; Type I hemidesmosome assembly; MET activates PTK2 signaling Focal adhesion; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q5F2F2 Protein ABHD15 OS=Mus musculus OX=10090 GN=Abhd15 PE=1 SV=1 0 12.646 10 5 6 5 459 51.1 7.99 5 6 144373.1758 153421.8281 122255.5391 3581217.563 2 1 1 4 metabolic process extracellular;membrane catalytic activity 67477 ENSMUSG00000000686.11 Abhd15 11 0 High Q8BMS4 "Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Coq3 PE=1 SV=1" 0 20.768 14 3 6 3 370 40.9 7.96 3 6 180843.5625 243354.1719 289460.2813 6629026.375 1 1 1 4 metabolic process;regulation of biological process membrane;mitochondrion catalytic activity "Pf01209, Pf02353, Pf06325, Pf08003, Pf08241, Pf08242, Pf09445, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847" 230027 ENSMUSG00000028247.2 Coq3 4 Ubiquinol biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways 0 High A0A0G2JGN4 Small nuclear ribonucleoprotein-associated protein B OS=Mus musculus OX=10090 GN=Snrpb PE=4 SV=1 0.007 2.009 10 1 6 1 70 8.4 9.07 1 1 1 2 2 2 227645.8281 1053277.625 973611.3125 1213041.625 1 1 1 1 regulation of biological process "Pf01423, Pf03614" ENSMUSG00000027404.15 2 0 High A0A1W2P7T3 Enhancer of rudimentary homolog OS=Mus musculus OX=10090 GN=Erh PE=1 SV=1 0 4.615 13 1 6 1 89 10.1 5.87 1 1 1 1 1 2 2 1 2458451.75 3293049.25 2959938.25 2308333.75 1 1 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process "Pf01133, Pf10898, Pf11887" ENSMUSG00000021131.14 12 0 High P62900 60S ribosomal protein L31 OS=Mus musculus OX=10090 GN=Rpl31 PE=1 SV=1 0 4.209 14 2 6 2 125 14.5 10.54 1 1 2 1 1 2 2 1 2139057.469 6049958.75 5109813.125 5333775 2 2 2 1 metabolic process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01198 114641 ENSMUSG00000073702.11 Rpl31 1 Ribosome 0 High Q9CXW2 "28S ribosomal protein S22, mitochondrial OS=Mus musculus OX=10090 GN=Mrps22 PE=1 SV=1" 0 10.11 10 3 6 3 359 41.2 8.56 2 1 3 2 1 3 1251075 1000861.438 1549145 2 2 2 mitochondrion;ribosome structural molecule activity Pf10245 64655 ENSMUSG00000032459.9 Mrps22 9 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q8VEK0 Cell cycle control protein 50A OS=Mus musculus OX=10090 GN=Tmem30a PE=1 SV=1 0 9.034 14 4 6 4 364 41 8.37 4 6 160365.4375 138812.2344 4738516.75 1 1 3 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding;transporter activity Pf03381 69981 ENSMUSG00000032328.12 Tmem30a 9 Neutrophil degranulation 0 High D3YTT4 "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acad8 PE=1 SV=1" 0 18.53 16 4 6 4 413 45 8.02 1 1 4 1 1 4 639774.9531 1173323.891 684211.6875 3601808.5 3 3 2 4 metabolic process catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" ENSMUSG00000031969.16 9 Branched-chain amino acid catabolism 0 High P60843 Eukaryotic initiation factor 4A-I OS=Mus musculus OX=10090 GN=Eif4a1 PE=1 SV=1 0 7.888 9 3 6 1 406 46.1 5.48 2 2 2 2 2 2 83376.25 226041.1875 268884.2813 347574.0625 1 1 1 1 metabolic process;regulation of biological process cytoplasm;membrane catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf04851" 13681 ENSMUSG00000059796.16 Eif4a1 11 L13a-mediated translational silencing of Ceruloplasmin expression; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Translation initiation complex formation; Deadenylation of mRNA RNA transport 0 High G3X9M0 "28S ribosomal protein S29, mitochondrial OS=Mus musculus OX=10090 GN=Dap3 PE=1 SV=1" 0 6.666 6 2 6 2 396 45.3 9.11 2 2 2 2 2 2 73436.875 1053014.313 937161.25 1247743.813 1 2 2 2 cell death;cell organization and biogenesis mitochondrion;organelle lumen;ribosome RNA binding;structural molecule activity "Pf05673, Pf10236" 65111 ENSMUSG00000068921.14 Dap3 3 0 High Q921M3 Splicing factor 3B subunit 3 OS=Mus musculus OX=10090 GN=Sf3b3 PE=1 SV=1 0 2.825 1 2 6 2 1217 135.5 5.26 1 2 2 2 2 2 200129.7031 488656.3125 415835.1875 429575.8438 1 1 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf03178, Pf10433" 101943 ENSMUSG00000033732.10 Sf3b3 8 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High Q9D1Q6 Endoplasmic reticulum resident protein 44 OS=Mus musculus OX=10090 GN=Erp44 PE=1 SV=1 0 18.917 13 4 6 4 406 46.8 5.27 4 6 629896.9375 588266.0234 1811150.195 10309223.28 1 2 3 4 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00085, Pf01216, Pf07449, Pf13098, Pf13848" 76299 ENSMUSG00000028343.10 Erp44 4 Neutrophil degranulation 0 High P24549 Retinal dehydrogenase 1 OS=Mus musculus OX=10090 GN=Aldh1a1 PE=1 SV=5 0 2.98 2 1 6 1 501 54.4 7.8 1 1 1 2 2 2 1632877.375 12793893 10602248 10183311 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00171, Pf05893, Pf07368" 11668 ENSMUSG00000053279.6 Aldh1a1 19 RA biosynthesis pathway; Ethanol oxidation; Fructose catabolism Retinol metabolism; Metabolic pathways 0 High J3QPZ9 Beta-enolase (Fragment) OS=Mus musculus OX=10090 GN=Eno3 PE=1 SV=1 0 16.684 15 2 6 1 190 20.6 5.11 1 2 2 1 2 3 994827 4315243.625 4080786.25 5984254 1 2 2 1 metabolic process catalytic activity;metal ion binding "Pf00113, Pf13378" ENSMUSG00000060600.15 11 0 High P35569 Insulin receptor substrate 1 OS=Mus musculus OX=10090 GN=Irs1 PE=1 SV=1 0 9.037 7 4 6 4 1233 130.6 8.73 1 4 1 1 4 1 147411.7813 1235952.938 833859.4844 180665.9531 1 3 3 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus protein binding;signal transducer activity "Pf00169, Pf02174" 16367 Irs1 1 Signaling by Leptin; Mus musculus biological processes FoxO signaling pathway; mTOR signaling pathway; Type II diabetes mellitus; MicroRNAs in cancer; Regulation of lipolysis in adipocytes; Insulin signaling pathway; Insulin resistance; Longevity regulating pathway; Non-alcoholic fatty liver disease (NAFLD); Neurotrophin signaling pathway; cGMP-PKG signaling pathway; Adipocytokine signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway - multiple species; Aldosterone-regulated sodium reabsorption 0 High A0A140LIS5 Arginine and glutamate-rich protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Arglu1 PE=1 SV=1 0 2.325 4 1 6 1 215 25.9 10.62 1 1 1 1 1 2 1 2 729702.9375 1267887.375 796483.5 895172.375 1 1 1 1 ENSMUSG00000040459.11 8 0 High P63158 High mobility group protein B1 OS=Mus musculus OX=10090 GN=Hmgb1 PE=1 SV=2 0 7.582 21 3 6 3 215 24.9 5.74 2 1 1 1 3 1 1 1 1562360.25 1024135.203 638191.8125 1065962.563 2 2 1 2 cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;chromosome;cytoplasm;endosome;extracellular;membrane;nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding "Pf00505, Pf09011" 15289; 100862258 ENSMUSG00000066551.12 Hmgb1; Gm21596; LOC100862258 5; 2 DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activation of DNA fragmentation factor; Activated TLR4 signalling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Neutrophil degranulation; TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; Interleukin-1 family signaling; Regulation of TLR by endogenous ligand Base excision repair 0 High E9QMW9 Polypyrimidine tract-binding protein 1 OS=Mus musculus OX=10090 GN=Ptbp1 PE=1 SV=1 0 4.9 6 2 6 2 353 37.1 8.13 2 2 1 2 3 1 195308.7656 1797401.781 1380330.219 1496936 1 2 2 2 metabolic process nucleus RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000006498.16 10 mRNA Splicing - Major Pathway; FGFR2 alternative splicing 0 High Q61102 "ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus OX=10090 GN=Abcb7 PE=1 SV=3" 0 27.671 11 6 6 6 752 82.5 9.32 6 6 815371.8125 978820.4375 876586.0078 4645487 2 1 2 4 cellular homeostasis;transport membrane;mitochondrion catalytic activity;nucleotide binding;transporter activity "Pf00005, Pf00664, Pf13207, Pf13304" 11306 ENSMUSG00000031333.7 Abcb7 X Mitochondrial ABC transporters ABC transporters 0 High Q63918 Caveolae-associated protein 2 OS=Mus musculus OX=10090 GN=Cavin2 PE=1 SV=3 0 10.093 8 3 6 3 418 46.7 5.21 2 2 2 2 2 2 857088.4219 2203403.656 1832526.75 2587426.813 3 3 3 3 cell organization and biogenesis;regulation of biological process cytoplasm;cytosol;membrane protein binding Pf15237 20324 ENSMUSG00000045954.7 Sdpr; Cavin2 1 0 High Q62087 Serum paraoxonase/lactonase 3 OS=Mus musculus OX=10090 GN=Pon3 PE=1 SV=2 0 14.563 13 4 6 4 354 39.3 5.74 4 6 99160.375 111511.7656 6694374.313 1 2 3 metabolic process;regulation of biological process;response to stimulus extracellular catalytic activity;metal ion binding;protein binding "Pf01731, Pf03088" 269823 ENSMUSG00000029759.9 Pon3 6 Synthesis of 5-eicosatetraenoic acids Metabolic pathways 0 High A0A2I3BPG9 "Ribosomal protein L36A, pseudogene 1 OS=Mus musculus OX=10090 GN=Rpl36a-ps1 PE=3 SV=1" 0 3.78 16 2 6 2 106 12.4 10.51 1 2 2 1 3 2 1503448 3799547.75 3748655.938 3914711.875 2 2 2 2 0 High Q8JZR0 Long-chain-fatty-acid--CoA ligase 5 OS=Mus musculus OX=10090 GN=Acsl5 PE=1 SV=1 0 10.939 6 3 6 2 683 76.2 7.09 1 1 3 1 1 4 806552.875 2 metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding Pf00501 433256 ENSMUSG00000024981.5 Acsl5 19 Synthesis of very long-chain fatty acyl-CoAs PPAR signaling pathway; Fatty acid metabolism; Metabolic pathways; Fatty acid degradation; Adipocytokine signaling pathway; Fatty acid biosynthesis; Peroxisome 0 High P62196 26S proteasome regulatory subunit 8 OS=Mus musculus OX=10090 GN=Psmc5 PE=1 SV=1 0 18.629 17 5 6 4 406 45.6 7.55 5 6 786556.5625 919766.9063 8185648.875 2 2 4 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401" 19184 ENSMUSG00000020708.12 Psmc5 11 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 1 High Q9WTM5 RuvB-like 2 OS=Mus musculus OX=10090 GN=Ruvbl2 PE=1 SV=3 0 7.431 7 3 6 3 463 51.1 5.64 1 2 2 1 2 3 168841.8125 1384393.125 1302180.938 3417425.875 1 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03796, Pf06068, Pf13481" 20174 ENSMUSG00000003868.14 Ruvbl2 7 0 High P62317 Small nuclear ribonucleoprotein Sm D2 OS=Mus musculus OX=10090 GN=Snrpd2 PE=1 SV=1 0 6.439 24 2 6 2 118 13.5 9.91 1 2 1 2 1 2 1 2 506202.1406 2167527.25 1691976.406 1683582.531 2 2 2 2 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex RNA binding Pf01423 107686 ENSMUSG00000040824.3 Snrpd2 7 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly Spliceosome 0 High A0A1W2P6G5 Myosin light polypeptide 6 OS=Mus musculus OX=10090 GN=Myl6 PE=1 SV=1 0 13.593 29 3 6 3 139 15.4 4.54 1 2 3 1 2 3 805984.875 1163152.344 2386567.125 1772068.844 2 2 3 3 metal ion binding Pf13499 ENSMUSG00000090841.2 10 0 High Q8K0C9 "GDP-mannose 4,6 dehydratase OS=Mus musculus OX=10090 GN=Gmds PE=1 SV=1" 0 15.698 13 4 6 4 372 42 7.03 1 4 1 5 100713.6016 1194413.68 1322855.234 4791334.125 1 3 3 4 metabolic process;regulation of biological process;response to stimulus catalytic activity;nucleotide binding;protein binding "Pf01370, Pf04321, Pf13460" 218138 ENSMUSG00000038372.13 Gmds 13 GDP-fucose biosynthesis Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Fructose and mannose metabolism 0 High A2ADH1 Magnesium transporter protein 1 OS=Mus musculus OX=10090 GN=Magt1 PE=1 SV=1 0 8.735 10 4 6 4 368 41.6 10.05 4 6 269930.4375 1058760.781 267885.8438 21726649.75 1 4 1 4 metabolic process;transport endoplasmic reticulum;membrane catalytic activity;transporter activity Pf04756 67075 ENSMUSG00000031232.16 Magt1 X Neutrophil degranulation; Miscellaneous transport and binding events 0 High E9Q5L3 "Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadsb PE=1 SV=1" 0 16.971 18 6 6 6 465 51.8 8.32 6 6 437085.6406 711899.9375 1728414.75 9612042.25 2 2 4 5 metabolic process membrane catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" ENSMUSG00000030861.15 7 0 High A0A1L1ST61 "HIG1 domain family member 1A, mitochondrial (Fragment) OS=Mus musculus OX=10090 GN=Higd1a PE=1 SV=1" 0 17.712 66 3 6 3 76 8.2 9.91 3 6 6557856.625 2 Met-loss+Acetyl [N-Term] membrane Pf04588 ENSMUSG00000038412.8 9 0 High E9Q705 BolA-like protein 3 OS=Mus musculus OX=10090 GN=Bola3 PE=1 SV=1 0 12.066 46 3 6 3 95 10.8 8.31 1 1 3 1 1 4 713785.8594 1130282.688 528639.875 3720169 2 2 1 2 Pf01722 ENSMUSG00000045160.14 6 0 High Q8BL63 GPI-anchor transamidase OS=Mus musculus OX=10090 GN=Pigk PE=1 SV=1 0 17.958 17 6 6 6 442 49.8 6.54 6 6 78507.89063 96159 2755595.563 1 1 4 metabolic process endoplasmic reticulum;membrane catalytic activity Pf01650 329777 ENSMUSG00000039047.17 Pigk 3 0 High Q01853 Transitional endoplasmic reticulum ATPase OS=Mus musculus OX=10090 GN=Vcp PE=1 SV=4 0 11.777 7 5 6 5 806 89.3 5.26 5 1 5 1 924229.5625 1403771.031 2587796.047 1552947.109 4 4 5 4 cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;proteasome catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401" 269523 ENSMUSG00000028452.7 Vcp 4 N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Protein methylation; Translesion Synthesis by POLH; HSF1 activation; Ovarian tumor domain proteases; Hedgehog ligand biogenesis; ABC-family proteins mediated transport; Neutrophil degranulation Legionellosis; Protein processing in endoplasmic reticulum 0 High O88325 Alpha-N-acetylglucosaminidase OS=Mus musculus OX=10090 GN=Naglu PE=1 SV=1 0 14.568 6 4 6 4 739 82.5 6.61 2 4 2 4 75571.90625 346010.8438 917969.2969 1624908.781 1 2 3 3 cell organization and biogenesis;response to stimulus catalytic activity "Pf05089, Pf12971, Pf12972" 27419 ENSMUSG00000001751.9 Naglu 11 HS-GAG degradation Metabolic pathways; Lysosome; Glycosaminoglycan degradation 0 High O54941 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus musculus OX=10090 GN=Smarce1 PE=1 SV=1 0 7.329 10 3 6 3 411 46.6 4.88 2 2 2 2 2 2 2863613.313 4012639.313 3930005.688 3140470.688 2 2 2 2 cell differentiation;cell organization and biogenesis;regulation of biological process nucleus catalytic activity;DNA binding;protein binding;RNA binding Pf00505 57376 ENSMUSG00000037935.16 Smarce1 11 RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 High Q99LT0 Protein dpy-30 homolog OS=Mus musculus OX=10090 GN=Dpy30 PE=1 SV=1 0.001 2.2 9 1 6 1 99 11.2 4.88 1 1 1 2 2 2 815073 2025117.75 1938727.75 1335667.25 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport Golgi;nucleus catalytic activity;protein binding Pf05186 66310 ENSMUSG00000024067.13 Dpy30 17 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines 0 High Q6PB66 "Leucine-rich PPR motif-containing protein, mitochondrial OS=Mus musculus OX=10090 GN=Lrpprc PE=1 SV=2" 0 5.822 2 3 5 3 1392 156.5 6.83 2 1 2 2 1 2 317880.5391 773148.1875 680475.25 1381975.688 2 2 2 2 metabolic process;regulation of biological process;transport chromosome;cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus catalytic activity;DNA binding;protein binding;RNA binding "Pf12854, Pf13041, Pf13812" 72416 ENSMUSG00000024120.12 Lrpprc 17 0 High P00405 Cytochrome c oxidase subunit 2 OS=Mus musculus OX=10090 GN=Mtco2 PE=1 SV=1 0 7.78 16 3 5 3 227 26 4.73 1 1 3 1 1 3 162936.4531 582736.4375 653787.25 3286983.75 1 1 1 1 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;transporter activity "Pf00116, Pf02790" 17709; 3338897 ENSMUSG00000064354.1 COX2 MT Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q922Q4 Pyrroline-5-carboxylate reductase 2 OS=Mus musculus OX=10090 GN=Pycr2 PE=1 SV=1 0 12.448 16 5 5 5 320 33.6 7.77 5 5 243737.6406 258003.2969 331770.0938 1839611 1 2 2 2 metabolic process;response to stimulus cytoplasm;mitochondrion catalytic activity;nucleotide binding "Pf01210, Pf03807, Pf10727, Pf14748" 69051 ENSMUSG00000026520.8 Pycr2 1 Amino acid synthesis and interconversion (transamination) Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids 0 High Q8BXA5 Cleft lip and palate transmembrane protein 1-like protein OS=Mus musculus OX=10090 GN=Clptm1l PE=1 SV=1 0 16.225 11 5 5 5 539 62.1 8.84 5 5 5624391.438 4 cell death membrane Pf05602 218335 ENSMUSG00000021610.7 Clptm1l 13 0 High H3BL49 T-complex protein 1 subunit theta OS=Mus musculus OX=10090 GN=Cct8 PE=1 SV=1 0 18.321 11 5 5 5 489 53 5.5 5 5 207280.2109 434086.4531 373078.5781 4584961.063 2 2 2 5 cell organization and biogenesis;metabolic process;transport nucleotide binding;protein binding Pf00118 ENSMUSG00000025613.13 16 0 High P60122 RuvB-like 1 OS=Mus musculus OX=10090 GN=Ruvbl1 PE=1 SV=1 0 3.722 2 1 5 1 456 50.2 6.42 1 1 1 1 1 1 1 2 346902.1875 810002.4375 764526.5625 1277151.5 1 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07726, Pf13191, Pf13238, Pf13245, Pf13481" 56505 ENSMUSG00000030079.15 Ruvbl1 6 DNA Damage Recognition in GG-NER; Ub-specific processing proteases; UCH proteinases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex Wnt signaling pathway 0 High G3UYV7 40S ribosomal protein S28 (Fragment) OS=Mus musculus OX=10090 GN=Rps28 PE=1 SV=1 0 6.358 36 2 5 2 56 6.3 9.96 1 2 1 1 1 2 1 1 236799.9219 1810857.563 681216.125 952069.625 1 2 1 1 metabolic process ribosome structural molecule activity Pf01200 ENSMUSG00000067288.12 17 0 High E9QN70 Laminin subunit beta-1 OS=Mus musculus OX=10090 GN=Lamb1 PE=1 SV=1 0 7.815 2 3 5 3 1834 202.3 5.01 1 1 3 1 1 3 229700.0625 984625.25 752795.3906 1714652.438 2 3 3 3 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport extracellular;nucleus catalytic activity;motor activity;protein binding;structural molecule activity "Pf00038, Pf00053, Pf00055, Pf01442, Pf01576, Pf05557, Pf05698, Pf06008, Pf07111, Pf08317, Pf08647, Pf09731, Pf13476, Pf13868, Pf15346" 16777 ENSMUSG00000002900.16 Lamb1 12 Focal adhesion; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High A0A494BAK4 Endoplasmic reticulum-Golgi intermediate compartment protein 1 OS=Mus musculus OX=10090 GN=Ergic1 PE=1 SV=1 0 10.993 17 4 5 4 247 27.7 7.61 1 4 1 4 212603.7344 893593.9063 499888.9844 8177569.125 2 3 2 4 0 High D3Z6S4 Leucine-rich repeat-containing G-protein-coupled receptor 6 OS=Mus musculus OX=10090 GN=Lgr6 PE=4 SV=1 0 13.325 11 5 5 5 690 73.6 5.96 5 5 2842908.063 3 regulation of biological process;response to stimulus membrane protein binding;receptor activity;signal transducer activity "Pf12799, Pf13855" ENSMUSG00000042793.13 1 0 High Q2TPA8 Hydroxysteroid dehydrogenase-like protein 2 OS=Mus musculus OX=10090 GN=Hsdl2 PE=1 SV=1 0 19.103 18 4 5 4 490 54.2 6.74 4 5 192088 756888.0625 8558442.563 1 1 4 metabolic process membrane;mitochondrion catalytic activity "Pf00106, Pf02036, Pf14864" 72479 ENSMUSG00000028383.17 Hsdl2 4 0 High Q9CZB6 Mediator of RNA polymerase II transcription subunit 7 OS=Mus musculus OX=10090 GN=Med7 PE=1 SV=2 0 10.642 24 3 5 3 233 27.2 5.66 2 1 2 2 1 2 1005606.188 2518252.219 1921110.75 2257519 1 2 1 1 metabolic process;regulation of biological process nucleus catalytic activity Pf05983 66213 ENSMUSG00000020397.15 Med7 11 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High Q9Z329 "Inositol 1,4,5-trisphosphate receptor type 2 OS=Mus musculus OX=10090 GN=Itpr2 PE=1 SV=4" 0 12.685 2 5 5 5 2701 307.3 6.44 1 4 1 4 358003.875 145591.4844 153598.5 1206739.531 2 1 1 3 cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;nucleus metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity "Pf01365, Pf02815, Pf08454, Pf08709, Pf12670" 16439 ENSMUSG00000030287.15 Itpr2 6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Effects of PIP2 hydrolysis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Gastrin-CREB signalling pathway via PKC and MAPK; Elevation of cytosolic Ca2+ levels Oxytocin signaling pathway; Cholinergic synapse; Retrograde endocannabinoid signaling; Pancreatic secretion; Dopaminergic synapse; NOD-like receptor signaling pathway; Long-term potentiation; Platelet activation; Thyroid hormone synthesis; Oocyte meiosis; Glutamatergic synapse; Proteoglycans in cancer; Long-term depression; cGMP-PKG signaling pathway; Calcium signaling pathway; Salivary secretion; Alzheimer's disease; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Gastric acid secretion; Renin secretion; Gap junction; Estrogen signaling pathway; Glucagon signaling pathway; Phosphatidylinositol signaling system; Serotonergic synapse; Inflammatory mediator regulation of TRP channels; Apoptosis 0 High P13020 Gelsolin OS=Mus musculus OX=10090 GN=Gsn PE=1 SV=3 0 12.849 7 4 5 4 780 85.9 6.18 1 4 1 4 443939.0391 1139476.5 1096998.625 3530435.375 3 3 3 4 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus metal ion binding;protein binding Pf00626 227753 ENSMUSG00000026879.14 Gsn 2 Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Viral carcinogenesis 0 High Q9CQE8 "RNA transcription, translation and transport factor protein OS=Mus musculus OX=10090 GN=RTRAF PE=1 SV=1" 0 4.897 12 2 5 2 244 28.1 6.89 1 1 2 1 1 1 2 1 798115.375 1233815.984 1419485.25 1173220.422 2 2 2 2 metabolic process;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus protein binding;RNA binding Pf10036 68045 ENSMUSG00000021807.5 2700060E02Rik; Rtraf 14 0 High A0A0G2JDI9 ATP-binding cassette sub-family D member 3 OS=Mus musculus OX=10090 GN=Abcd3 PE=1 SV=1 0 21.092 14 5 5 5 549 62.7 9.13 5 5 607667.9375 1693016 1665724.25 3628149.281 1 1 1 5 transport catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00005, Pf06472" ENSMUSG00000028127.10 3 0 High Q9D1I6 "39S ribosomal protein L14, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl14 PE=1 SV=1" 0 2.389 12 2 5 2 145 15.9 10.99 2 1 1 2 1 2 452021.7266 1510551.813 387244.3438 689668.1875 2 2 1 1 metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00238 68463 ENSMUSG00000023939.7 Mrpl14 17 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High Q8BXZ1 Protein disulfide-isomerase TMX3 OS=Mus musculus OX=10090 GN=Tmx3 PE=1 SV=2 0 18.404 17 5 5 5 456 51.8 5.16 5 5 105836.7422 6737985.25 1 5 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;membrane catalytic activity "Pf00085, Pf13098, Pf13848, Pf13899" 67988 ENSMUSG00000024614.6 Tmx3 18 Platelet degranulation 0 High Q8C0L0 Thioredoxin-related transmembrane protein 4 OS=Mus musculus OX=10090 GN=Tmx4 PE=1 SV=2 0 10.825 12 3 5 3 335 37.1 4.37 3 5 290679.3125 460182.5938 6097382.313 1 1 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity Pf00085 52837 ENSMUSG00000034723.11 Tmx4 2 0 High Q8VDN2 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Mus musculus OX=10090 GN=Atp1a1 PE=1 SV=1 0 23.765 7 5 5 1 1023 112.9 5.45 5 5 389330.1875 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;Golgi;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity "Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246" 11928 ENSMUSG00000033161.10 Atp1a1 3 Ion transport by P-type ATPases; Ion homeostasis Pancreatic secretion; Carbohydrate digestion and absorption; Mineral absorption; Protein digestion and absorption; Endocrine and other factor-regulated calcium reabsorption; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Proximal tubule bicarbonate reclamation; cGMP-PKG signaling pathway; Bile secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Gastric acid secretion; Insulin secretion; Adrenergic signaling in cardiomyocytes; Aldosterone-regulated sodium reabsorption 0 High A0A140T8T4 "Ribosomal protein L9, pseudogene 6 OS=Mus musculus OX=10090 GN=Rpl9-ps6 PE=4 SV=1" 0 10.083 11 3 5 3 192 21.8 9.88 1 1 3 1 1 3 1060481.141 2008184.031 2106721.094 3834989.969 3 2 3 3 metabolic process ribosome RNA binding;structural molecule activity Pf00347 100042823 ENSMUSG00000062456.3 Rpl9-ps6 19 0 High Q3TQB2 FAD-dependent oxidoreductase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Foxred1 PE=1 SV=1 0 6.858 9 4 5 4 487 54.1 7.53 1 1 3 1 1 3 335965.7969 348934.3047 3939953.688 2 2 4 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity Pf01266 235169 ENSMUSG00000039048.15 Foxred1 9 0 High Q8R404 MICOS complex subunit MIC13 OS=Mus musculus OX=10090 GN=Micos13 PE=1 SV=1 0 12.152 35 2 5 2 119 13.4 8.63 1 2 1 4 35241.24219 808865.8672 186620.2813 2224776.406 1 2 1 2 cell organization and biogenesis membrane;mitochondrion 224904 ENSMUSG00000049760.5 2410015M20Rik 17 0 High Q8JZN5 "Complex I assembly factor ACAD9, mitochondrial OS=Mus musculus OX=10090 GN=Acad9 PE=1 SV=2" 0 9.556 5 3 5 3 625 68.7 7.46 1 1 3 1 1 3 634829.2969 622654.8438 3039117.313 2 2 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 229211 ENSMUSG00000027710.14 Acad9 3 Complex I biogenesis 0 High Q5SUF2 Luc7-like protein 3 OS=Mus musculus OX=10090 GN=Luc7l3 PE=1 SV=1 0 10.074 7 2 5 2 432 51.4 9.77 2 1 3 2 855696.2188 3649796.313 2959697.438 2184173 1 2 2 2 cell organization and biogenesis;metabolic process nucleus;spliceosomal complex DNA binding;RNA binding Pf03194 67684 ENSMUSG00000020863.15 Luc7l3 11 0 High Q8BUE4 Ferroptosis suppressor protein 1 OS=Mus musculus OX=10090 GN=Aifm2 PE=1 SV=1 0 10.767 10 3 5 3 373 40.6 8.98 1 1 3 1 1 3 718479.7813 1511622.047 1169269.594 3208826.875 2 3 3 3 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;DNA binding;nucleotide binding "Pf00070, Pf07992" 71361 ENSMUSG00000020085.15 Aifm2 10 0 High P50171 Estradiol 17-beta-dehydrogenase 8 OS=Mus musculus OX=10090 GN=Hsd17b8 PE=1 SV=2 0 19.498 19 3 5 3 259 26.6 6.54 3 5 3615647.563 2 cell organization and biogenesis;metabolic process membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00106, Pf08659, Pf13561" 14979 ENSMUSG00000073422.10 H2-Ke6 17 Fatty acyl-CoA biosynthesis Steroid hormone biosynthesis; Metabolic pathways 0 High A0A0R4J0Q4 Lysyl oxidase homolog 1 OS=Mus musculus OX=10090 GN=Loxl1 PE=4 SV=1 0 13.267 10 5 5 5 607 66.5 7.33 5 5 157790.5781 2565384.688 1 4 metabolic process;response to stimulus cytoplasm;extracellular catalytic activity;metal ion binding;protein binding Pf01186 16949 ENSMUSG00000032334.10 Loxl1 9 Elastic fibre formation; Crosslinking of collagen fibrils 0 High P97927 Laminin subunit alpha-4 OS=Mus musculus OX=10090 GN=Lama4 PE=1 SV=2 0 8.222 2 3 5 3 1816 201.7 6.21 1 1 3 1 1 3 54527.85156 440522.5938 325162.7188 633378.875 1 1 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process cytoskeleton;extracellular protein binding "Pf00053, Pf00054, Pf02210, Pf03302, Pf04849, Pf05149, Pf05483, Pf06008, Pf06009, Pf06160, Pf10174, Pf12128, Pf13385, Pf13514" 16775 ENSMUSG00000019846.11 Lama4 10 MET activates PTK2 signaling; Laminin interactions African trypanosomiasis; Focal adhesion; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q9DCD0 "6-phosphogluconate dehydrogenase, decarboxylating OS=Mus musculus OX=10090 GN=Pgd PE=1 SV=3" 0 10.718 8 4 5 4 483 53.2 7.23 4 5 173818.1875 666840.5469 182354.4688 6435617.625 1 3 1 4 metabolic process cytoplasm;nucleus catalytic activity;nucleotide binding "Pf00393, Pf03446" 110208 ENSMUSG00000028961.15 Pgd 4 Pentose phosphate pathway (hexose monophosphate shunt) Glutathione metabolism; Metabolic pathways; Pentose phosphate pathway; Carbon metabolism 0 High Q02105 Complement C1q subcomponent subunit C OS=Mus musculus OX=10090 GN=C1qc PE=1 SV=2 0 2.431 4 1 5 1 246 26 8.54 1 1 1 1 2 2 302218.2813 5212347.375 6178975.875 3200044 1 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00229, Pf00386, Pf01391" 12262 ENSMUSG00000036896.5 C1qc 4 Regulation of Complement cascade; Classical antibody-mediated complement activation Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Prion diseases; Systemic lupus erythematosus 0 High Q8VCE9 Pleckstrin homology domain-containing family H member 3 OS=Mus musculus OX=10090 GN=Plekhh3 PE=2 SV=1 0 10.96 12 5 5 5 796 85.8 7.3 5 5 264632.4688 1501559.5 1 3 regulation of biological process;response to stimulus cytoskeleton "Pf00169, Pf00784, Pf00788" 217198 ENSMUSG00000035172.15 Plekhh3 11 0 High P62855 40S ribosomal protein S26 OS=Mus musculus OX=10090 GN=Rps26 PE=1 SV=3 0 5.219 27 3 5 3 115 13 11 2 1 2 2 1 2 3137029.25 13648515.38 10300569.5 12324177.25 2 3 2 3 metabolic process;regulation of biological process membrane;ribosome protein binding;RNA binding;structural molecule activity Pf01283 27370; 100042812 ENSMUSG00000025362.6 Rps26; Rps26-ps1 10; 8 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9DA19 Corepressor interacting with RBPJ 1 OS=Mus musculus OX=10090 GN=Cir1 PE=1 SV=2 0 4.165 5 2 5 2 450 51.8 9.92 2 1 1 1 2 1 1 1 426313.4531 736541.375 822477.4375 551071.9219 2 2 2 2 metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus protein binding Pf10197 66935 ENSMUSG00000041777.11 Cir1 2 Notch signaling pathway 0 High F8WHX2 Copper homeostasis protein cutC homolog OS=Mus musculus OX=10090 GN=Cutc PE=1 SV=1 0 9.206 17 3 5 3 262 27.9 7.94 2 2 1 2 2 1 82776.49219 878150.875 677556.4531 720899.1875 1 2 2 2 cell organization and biogenesis cytoplasm;cytosol;nucleus metal ion binding Pf03932 66388 ENSMUSG00000025193.14 Cutc 19 0 High Q6P9Z1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 OS=Mus musculus OX=10090 GN=Smarcd3 PE=1 SV=2 0 5.464 8 3 5 1 483 55 9.35 3 2 3 2 190228.4688 476084.5625 426375.4688 491149.3438 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus protein binding Pf02201 66993 ENSMUSG00000028949.13 Smarcd3 5 RMTs methylate histone arginines; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha); RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 High A0A5F8MPU6 Very-long-chain enoyl-CoA reductase (Fragment) OS=Mus musculus OX=10090 GN=Tecr PE=1 SV=1 0 10.918 13 3 5 3 206 24 9.28 3 5 5298081.117 8755337.703 970566.5781 9105937.906 2 3 3 3 0 High E9Q317 Histone deacetylase complex subunit SAP18 OS=Mus musculus OX=10090 GN=Sap18 PE=1 SV=1 0 3.524 11 2 5 2 172 19.6 9.8 1 2 2 3 443295.2109 1276304.75 1714422.125 1889341.813 2 1 2 2 Acetyl [N-Term] regulation of biological process cytosol protein binding;RNA binding Pf06487 20220; 100041953 ENSMUSG00000021963.16; ENSMUSG00000061104.5 Sap18; Gm10094; Sap18b 14; 8 mRNA surveillance pathway; RNA transport 0 High Q6P6L6 Gem (Nuclear organelle) associated protein 4 OS=Mus musculus OX=10090 GN=Gemin4 PE=1 SV=1 0 11.944 4 3 5 3 1058 120.1 5.15 1 1 2 1 1 3 1592885.227 1236805.254 3567724.297 3 3 3 cell organization and biogenesis;metabolic process cytosol;membrane 276919 ENSMUSG00000049396.6 Gemin4 11 snRNP Assembly RNA transport 0 High Q07417 "Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acads PE=1 SV=2" 0 7.714 7 3 5 3 412 44.9 8.47 1 1 3 1 1 3 263711.4063 569261.6719 625128.3281 1552866.781 1 2 3 3 cell organization and biogenesis;metabolic process membrane;mitochondrion;nucleus;organelle lumen catalytic activity;nucleotide binding "Pf00441, Pf02770, Pf02771, Pf08028" 11409 ENSMUSG00000029545.13 Acads 5 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA "Fatty acid metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Fatty acid degradation; Butanoate metabolism; Carbon metabolism" 0 High Q9CZN7 "Serine hydroxymethyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Shmt2 PE=1 SV=1" 0 6.308 4 2 5 2 504 55.7 8.47 1 2 2 1 2 2 33951.16797 684989.4375 745297.9531 1169659.031 1 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus;organelle lumen catalytic activity;protein binding Pf00464 108037 ENSMUSG00000025403.5 Shmt2 10 Metabolism of folate and pterines "Metabolic pathways; Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Antifolate resistance; Carbon metabolism; One carbon pool by folate; Glyoxylate and dicarboxylate metabolism" 0 High F6YX19 Phosphatidylinositol-glycan biosynthesis class X protein OS=Mus musculus OX=10090 GN=Pigx PE=1 SV=1 0 21.021 29 5 5 5 252 28.4 6.4 5 5 820824 6021845.875 1 3 metabolic process membrane Pf08320 ENSMUSG00000023791.15 16 0 High P54923 [Protein ADP-ribosylarginine] hydrolase OS=Mus musculus OX=10090 GN=Adprh PE=1 SV=1 0 20.03 14 4 5 4 362 40 5.76 4 5 64182.28516 7199673.156 1 4 metabolic process;regulation of biological process;transport catalytic activity;enzyme regulator activity;metal ion binding;protein binding Pf03747 11544 ENSMUSG00000002844.8 Adprh 16 0 High Q6P5B0 RRP12-like protein OS=Mus musculus OX=10090 GN=Rrp12 PE=1 SV=1 0 6.743 3 3 5 3 1295 143 8.91 2 1 2 2 1 2 175231.2969 2734891.281 2837013.969 3312096.813 1 3 3 3 membrane;nucleus RNA binding Pf08161 107094 ENSMUSG00000035049.3 Rrp12 19 0 High Q8C050 Ribosomal protein S6 kinase alpha-5 OS=Mus musculus OX=10090 GN=Rps6ka5 PE=1 SV=2 0 15.108 8 5 5 5 863 96.5 7.34 5 5 438297.1484 705234.0625 694484.5605 2818593.059 2 1 2 5 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf00433, Pf01636, Pf06293, Pf07714, Pf14531" 73086 ENSMUSG00000021180.8 Rps6ka5 12 NCAM signaling for neurite out-growth; Activated TLR4 signalling; CREB phosphorylation; CD209 (DC-SIGN) signaling; ERK/MAPK targets MAPK signaling pathway; MicroRNAs in cancer; TNF signaling pathway; Neurotrophin signaling pathway; Circadian entrainment; Adrenergic signaling in cardiomyocytes; Bladder cancer 0 High B1AU76 Nuclear autoantigenic sperm protein OS=Mus musculus OX=10090 GN=Nasp PE=1 SV=1 0 5.429 9 3 5 3 448 48.7 4.45 2 1 1 3 1 1 2281511.375 2617958.5 3333298.313 2 3 3 cell organization and biogenesis;cell proliferation;metabolic process;transport cytoplasm;nucleus protein binding "Pf10516, Pf13414, Pf13424" 50927 ENSMUSG00000028693.15 Nasp 4 0 High G3UWX1 Replication factor C subunit 1 OS=Mus musculus OX=10090 GN=Rfc1 PE=1 SV=2 0 6.304 5 4 5 4 1145 127.5 9.31 1 3 1 1 3 1 177620.8672 1571567.156 1519934.563 1731227.094 2 4 4 3 metabolic process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;RNA binding "Pf00004, Pf00533, Pf00910, Pf03215, Pf05496, Pf08519, Pf12738, Pf13207, Pf13238" ENSMUSG00000029191.16 5 Termination of translesion DNA synthesis; Polymerase switching on the C-strand of the telomere; Translesion Synthesis by POLH; Translesion synthesis by POLI; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Dual Incision in GG-NER; Translesion synthesis by REV1; HDR through Homologous Recombination (HRR); Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Polymerase switching 0 High B9EJ54 Nucleoporin 205 OS=Mus musculus OX=10090 GN=Nup205 PE=1 SV=1 0 13.406 3 5 5 5 2008 227.3 6.34 5 5 101263.3359 2184661.453 1 4 cell organization and biogenesis membrane structural molecule activity Pf11894 70699 ENSMUSG00000038759.15 Nup205 6 Transcriptional regulation by small RNAs; SUMOylation of RNA binding proteins; snRNP Assembly; SUMOylation of chromatin organization proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins; SUMOylation of DNA replication proteins RNA transport 0 High F6V6T4 Transmembrane emp24 domain-containing protein 2 (Fragment) OS=Mus musculus OX=10090 GN=Tmed2 PE=1 SV=1 0 17.612 28 3 5 3 176 20 9.07 3 5 8215939.75 2 regulation of biological process;transport membrane Pf01105 ENSMUSG00000029390.13 5 0 High Q3ULG5 DNA helicase OS=Mus musculus OX=10090 GN=Mcm6 PE=1 SV=1 0 10.697 7 4 5 4 794 89.7 5.9 2 3 2 3 154920.6914 580806.8125 744970.1875 1035550.844 2 3 3 3 Acetyl [N-Term] metabolic process nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf01078, Pf07728, Pf14551" 17219 ENSMUSG00000026355.11 Mcm6 1 0 High A0A0R4J0V5 DNA-directed RNA polymerase subunit OS=Mus musculus OX=10090 GN=Polr2a PE=1 SV=1 0 7.83 3 4 5 4 1932 213.3 7.43 3 2 3 2 1940793.125 1316359.969 2392937.406 4 3 4 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000" 20020 ENSMUSG00000005198.15 Polr2a 11 0 High A0A087WPH7 26S proteasome regulatory subunit 6A (Fragment) OS=Mus musculus OX=10090 GN=Psmc3 PE=1 SV=6 0 8.672 14 3 5 3 305 34 4.98 1 1 3 1 1 3 324779.4375 568405.4219 2293552.313 2 2 2 metabolic process;regulation of biological process;response to stimulus catalytic activity;nucleotide binding "Pf00004, Pf01078, Pf01695, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191" ENSMUSG00000002102.15 2 0 High A0A087WP00 Nucleolar protein 58 (Fragment) OS=Mus musculus OX=10090 GN=Nop58 PE=1 SV=1 0 8.676 15 2 5 2 195 21.4 9.76 1 1 2 2 1 2 396108.4688 742753 1108840.281 2092744.25 2 2 2 3 Pf01798 ENSMUSG00000026020.9 1 0 High A0A571BEL9 T-complex protein 1 subunit zeta OS=Mus musculus OX=10090 GN=Cct6a PE=1 SV=1 0 7.159 10 4 5 4 532 58.5 6.25 1 4 1 4 156744.3945 520109.4609 498467.7656 1576312.023 2 3 2 4 0 High Q9D8V0 Minor histocompatibility antigen H13 OS=Mus musculus OX=10090 GN=Hm13 PE=1 SV=1 0 5.078 12 2 5 2 378 41.7 6.04 1 1 2 1 2 2 833396 1059242.375 1277634.25 1 1 1 metabolic process cell surface;endoplasmic reticulum;membrane catalytic activity;protein binding "Pf04258, Pf06550" 14950 ENSMUSG00000019188.16 H13 2 0 High Q9D8N0 Elongation factor 1-gamma OS=Mus musculus OX=10090 GN=Eef1g PE=1 SV=3 0 5.467 5 2 5 2 437 50 6.74 1 1 1 2 1 1 1 2 551249.7656 727698.7969 464535.0156 1023926.063 2 2 2 2 metabolic process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;nucleus catalytic activity;protein binding;RNA binding "Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497" 67160 ENSMUSG00000071644.10 Eef1g 19 Eukaryotic Translation Elongation Legionellosis 0 High Q9CWU3 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Mus musculus OX=10090 GN=Ppp2r2a PE=1 SV=1 0 10.74 10 3 5 3 367 42.6 5.36 1 1 3 1 1 3 694897.5625 531442.375 2094991.594 1 1 3 metabolic process;regulation of biological process;response to stimulus cytosol catalytic activity;enzyme regulator activity;protein binding 71978 Ppp2r2a 14 0 High O35375 Neuropilin-2 OS=Mus musculus OX=10090 GN=Nrp2 PE=1 SV=2 0 15.039 8 5 5 5 931 104.6 5.24 5 5 3235536.563 4 cell differentiation;cell growth;cellular component movement;development;regulation of biological process;response to stimulus membrane catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00431, Pf00629, Pf00754, Pf11980" 18187 ENSMUSG00000025969.15 Nrp2 1 Neurophilin interactions with VEGF and VEGFR 0 High Q9ESX4 Nucleolar protein of 40 kDa OS=Mus musculus OX=10090 GN=Zcchc17 PE=1 SV=1 0 5.267 16 2 4 2 241 27.5 9.63 2 1 1 2 1 1 1014642.625 604267.625 974427 450128.5625 1 1 1 1 nucleus metal ion binding;RNA binding Pf00575 619605 ENSMUSG00000028772.19; ENSMUSG00000108747.1 Zcchc17 4; CHR_MG4265_PATCH 0 High Q9R045 Angiopoietin-related protein 2 OS=Mus musculus OX=10090 GN=Angptl2 PE=2 SV=2 0 5.222 5 2 4 2 493 57.1 7.75 1 1 2 1 1 2 1530618.625 1220447.375 1227859.313 2 2 2 extracellular Pf00147 26360 ENSMUSG00000004105.8 Angptl2 2 0 High Q9JIK5 Nucleolar RNA helicase 2 OS=Mus musculus OX=10090 GN=Ddx21 PE=1 SV=3 0 4.653 2 2 4 2 851 93.5 9.11 1 1 2 1 1 2 233596.375 653968.6719 690744.2188 622437.5625 2 2 2 2 cell differentiation;metabolic process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf08152, Pf14617" 56200 ENSMUSG00000020075.8 Ddx21 10 Major pathway of rRNA processing in the nucleolus and cytosol; B-WICH complex positively regulates rRNA expression 0 High A3KFM7 Chromodomain-helicase-DNA-binding protein 6 OS=Mus musculus OX=10090 GN=Chd6 PE=1 SV=1 0 9.767 1 2 4 2 2711 305.2 6.38 2 2 2 2 544954 1196666.125 1213632.375 1 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00176, Pf00270, Pf00271, Pf00385, Pf07533" 71389 ENSMUSG00000057133.14 Chd6 2 0 High Q99JY9 Actin-related protein 3 OS=Mus musculus OX=10090 GN=Actr3 PE=1 SV=3 0 12.685 12 4 4 4 418 47.3 5.88 4 4 123906.5234 1535861.234 2 4 cell differentiation;cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane nucleotide binding;protein binding;structural molecule activity Pf00022 74117 ENSMUSG00000026341.16 Actr3 1 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation 0 High P62192 26S proteasome regulatory subunit 4 OS=Mus musculus OX=10090 GN=Psmc1 PE=1 SV=1 0 9.956 11 4 4 3 440 49.2 6.21 1 3 1 3 177914.2031 1869720.406 1 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf05673, Pf05729, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 19179 ENSMUSG00000021178.8 Psmc1 12 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection; Viral carcinogenesis 0 High A0A286YDA2 Nucleolar and coiled-body phosphoprotein 1 OS=Mus musculus OX=10090 GN=Nolc1 PE=1 SV=1 0 2.878 1 1 4 1 700 73.4 9.35 1 1 1 1 1 1 1 1 1131021.375 1277896.375 1434212.25 976114.75 1 1 1 1 0 High Q91V41 Ras-related protein Rab-14 OS=Mus musculus OX=10090 GN=Rab14 PE=1 SV=3 0 5.32 19 2 4 2 215 23.9 6.21 1 1 2 1 1 2 443994.4375 965141.3125 989361.0625 3733945.375 1 1 1 2 cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport cytosol;endoplasmic reticulum;endosome;Golgi;membrane;vacuole catalytic activity;nucleotide binding;protein binding "Pf00009, Pf00025, Pf00071, Pf04670, Pf08477" 68365 ENSMUSG00000026878.16 Rab14 2 RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the plasma membrane; Neutrophil degranulation AMPK signaling pathway 0 High P25206 DNA replication licensing factor MCM3 OS=Mus musculus OX=10090 GN=Mcm3 PE=1 SV=2 0 10.768 8 4 4 4 812 91.5 5.55 4 4 480182.9844 180684.875 2082389.766 2 1 3 metabolic process cytoplasm;membrane;nucleus catalytic activity;DNA binding;nucleotide binding "Pf00493, Pf01078, Pf07728, Pf14551" 17215 ENSMUSG00000041859.10 Mcm3 1 Removal of licensing factors from origins; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Orc1 removal from chromatin; M/G1 Transition; Activation of ATR in response to replication stress; Regulation of DNA replication DNA replication; Cell cycle 0 High P61211 ADP-ribosylation factor-like protein 1 OS=Mus musculus OX=10090 GN=Arl1 PE=1 SV=1 0 12.315 17 3 4 3 181 20.4 5.72 3 4 280952.7188 327789.2188 3464090.688 1 1 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 104303 ENSMUSG00000060904.14 Arl1 10 Retrograde transport at the Trans-Golgi-Network 0 High P58022 Lysyl oxidase homolog 2 OS=Mus musculus OX=10090 GN=Loxl2 PE=1 SV=2 0 7.532 3 1 4 1 776 86.9 6.57 1 1 1 1 1 1 1 1 587987.5313 1227723.938 531605.75 700439.5625 2 2 1 1 cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;extracellular;membrane;nucleus catalytic activity;metal ion binding;protein binding;receptor activity "Pf00530, Pf01186" 94352 ENSMUSG00000034205.16 Loxl2 14 0 High E9PUQ3 NKAP domain-containing 1 OS=Mus musculus OX=10090 GN=Nkapd1 PE=1 SV=1 0 4.79 9 2 4 2 292 33.9 9.74 2 1 3 1 5689359.438 206017.2656 4040505.344 191382.8281 3 1 2 1 270156 ENSMUSG00000059820.14 AU019823 9 0 High P62320 Small nuclear ribonucleoprotein Sm D3 OS=Mus musculus OX=10090 GN=Snrpd3 PE=1 SV=1 0 3.619 24 2 4 2 126 13.9 10.32 1 1 2 1 1 2 449410.3438 850615.4063 879319.1563 1 2 2 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex protein binding;RNA binding Pf01423 67332 ENSMUSG00000020180.10 Snrpd3 10 mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; mRNA Splicing - Major Pathway; snRNP Assembly; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs Spliceosome; Systemic lupus erythematosus 0 High Q3UHJ0 AP2-associated protein kinase 1 OS=Mus musculus OX=10090 GN=Aak1 PE=1 SV=2 0 4.198 6 2 4 1 959 103.3 6.7 2 1 1 2 1 1 560297.9375 421694.5 419776.0625 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 269774 ENSMUSG00000057230.13 Aak1 6 Cargo recognition for clathrin-mediated endocytosis 1 High A0A1D5RLV7 WD repeat and FYVE domain-containing protein 3 OS=Mus musculus OX=10090 GN=Wdfy3 PE=1 SV=1 0 5.794 1 3 4 3 3512 392.6 6.74 1 1 2 1 1 2 1154723.813 951352.1875 1688521.313 3 3 3 cell communication;metabolic process;response to stimulus cytoplasm;cytosol;membrane;nucleus;vacuole catalytic activity;metal ion binding;protein binding "Pf00400, Pf01363, Pf02138, Pf13385, Pf14844" 72145 ENSMUSG00000043940.15 Wdfy3 5 0 High O70302 Cell death activator CIDE-A OS=Mus musculus OX=10090 GN=Cidea PE=1 SV=2 0 7.526 15 3 4 3 217 24.7 9.36 3 4 2233215.188 2 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;mitochondrion;nucleus protein binding Pf02017 12683 ENSMUSG00000024526.8 Cidea 18 Lipid particle organization 0 High P53986 Monocarboxylate transporter 1 OS=Mus musculus OX=10090 GN=Slc16a1 PE=1 SV=1 0 6.002 6 2 4 2 493 53.2 7.47 2 4 6133663.5 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;transporter activity "Pf00083, Pf07690" 20501 ENSMUSG00000032902.1 Slc16a1 3 Basigin interactions; Proton-coupled monocarboxylate transport; Pyruvate metabolism 0 High Q9JKF1 Ras GTPase-activating-like protein IQGAP1 OS=Mus musculus OX=10090 GN=Iqgap1 PE=1 SV=2 0 4.836 1 2 4 2 1657 188.6 6.48 1 2 1 1 2 1 311808.4766 702109.4063 919543.6875 630825.5313 2 2 2 2 cell growth;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus enzyme regulator activity;protein binding "Pf00307, Pf00616, Pf03836, Pf11016" 29875 ENSMUSG00000030536.10 Iqgap1 7 Nephrin family interactions; RHO GTPases activate IQGAPs; Neutrophil degranulation Regulation of actin cytoskeleton; Adherens junction; Proteoglycans in cancer 0 High P14685 26S proteasome non-ATPase regulatory subunit 3 OS=Mus musculus OX=10090 GN=Psmd3 PE=1 SV=3 0 12.572 10 4 4 4 530 60.7 8.44 4 4 164370.9688 512625.7344 2081399.25 1 2 2 metabolic process;regulation of biological process membrane;nucleus;proteasome enzyme regulator activity;protein binding "Pf01399, Pf08375" 22123 ENSMUSG00000017221.14 Psmd3 11 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High A0A2I3BRT4 Epiplakin OS=Mus musculus OX=10090 GN=Eppk1 PE=1 SV=1 0 6.962 4 3 4 3 3458 381.5 5.92 1 2 1 1 2 1 1189737.266 1023962.906 608665.5 1122177.219 3 2 1 3 0 High Q3TCN2 Putative phospholipase B-like 2 OS=Mus musculus OX=10090 GN=Plbd2 PE=1 SV=2 0 3 1 1 4 1 594 66.2 6.13 1 1 1 3 1890401.5 1363761 1652740.375 2253405.344 1 1 1 2 metabolic process organelle lumen;vacuole catalytic activity Pf04916 71772 ENSMUSG00000029598.12 Plbd2 5 0 High Q14C51 "Pentatricopeptide repeat domain-containing protein 3, mitochondrial OS=Mus musculus OX=10090 GN=Ptcd3 PE=1 SV=2" 0 3.985 3 2 4 2 685 77.7 5.88 1 2 1 1 2 1 497773.4531 499283.4844 632911.625 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane;mitochondrion;ribosome RNA binding "Pf12854, Pf13041" 69956 ENSMUSG00000063884.6 Ptcd3 6 Mitochondrial translation termination; Mitochondrial translation elongation 0 High A0A0R4J1N9 "Transcription factor A, mitochondrial OS=Mus musculus OX=10090 GN=Tfam PE=1 SV=1" 0 4.859 10 2 4 2 199 23.4 9.72 2 2 2 2 380378 881571.3125 714050.125 597304.5938 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process mitochondrion;nucleus DNA binding;protein binding;RNA binding "Pf00505, Pf09011" 21780 ENSMUSG00000003923.14 Tfam 10 0 High D3YTP8 U6 snRNA-associated Sm-like protein LSm4 (Fragment) OS=Mus musculus OX=10090 GN=Lsm4 PE=1 SV=8 0.008 1.955 8 1 4 1 96 11.1 8.88 1 1 1 1 1 1 1 1 621686.625 552129.25 767488.75 426976.1563 1 1 1 1 Met-loss [N-Term] metabolic process Pf01423 ENSMUSG00000031848.15; ENSMUSG00000110900.1 8; CHR_MG190_MG3751_PATCH mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease 0 High P50428 Arylsulfatase A OS=Mus musculus OX=10090 GN=Arsa PE=1 SV=2 0 19.848 17 3 4 3 506 53.7 5.87 3 4 1545606.281 2 metabolic process;response to stimulus cytoplasm;endosome;membrane;vacuole catalytic activity;metal ion binding "Pf00884, Pf07394, Pf14707" 11883 ENSMUSG00000022620.14 Arsa 15 Neutrophil degranulation; Glycosphingolipid metabolism; The activation of arylsulfatases Lysosome; Sphingolipid metabolism 0 High P61750 ADP-ribosylation factor 4 OS=Mus musculus OX=10090 GN=Arf4 PE=1 SV=2 0 9.121 16 3 4 2 180 20.4 7.14 3 4 489129.9688 2030492.75 2381845.5 15773473 2 2 2 2 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;Golgi;membrane catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439" 11843 ENSMUSG00000021877.11 Arf4 14 VxPx cargo-targeting to cilium; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q61171 Peroxiredoxin-2 OS=Mus musculus OX=10090 GN=Prdx2 PE=1 SV=3 0 2.863 6 1 4 1 198 21.8 5.41 1 1 1 1 1 1 1 1 1157269 1650139.75 2246891.75 1778593.5 1 1 1 1 cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;mitochondrion antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 21672 ENSMUSG00000005161.15 Prdx2 8 Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes 0 High P62315 Small nuclear ribonucleoprotein Sm D1 OS=Mus musculus OX=10090 GN=Snrpd1 PE=1 SV=1 0 4.926 28 2 4 2 119 13.3 11.56 1 1 2 1 1 2 464178 1672462.313 1489846.359 1393387.688 1 2 2 2 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus;spliceosomal complex RNA binding Pf01423 20641 ENSMUSG00000002477.4 Snrpd1 18 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly Spliceosome; Systemic lupus erythematosus 0 High P19536 "Cytochrome c oxidase subunit 5B, mitochondrial OS=Mus musculus OX=10090 GN=Cox5b PE=1 SV=1" 0 5.393 16 2 4 2 128 13.8 8.38 2 4 508344.7188 1326561.219 7673460.5 1 2 2 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;transporter activity Pf01215 12859 Cox5b 1 0 High Q91VC9 Growth hormone-inducible transmembrane protein OS=Mus musculus OX=10090 GN=Ghitm PE=1 SV=1 0 8.653 9 3 4 3 346 37.3 9.8 1 3 1 3 1470982.5 1578089.813 6350846 2 2 2 cell death membrane;mitochondrion "Pf01027, Pf12811" 66092 ENSMUSG00000041028.15 Ghitm 14 0 High Q9EP69 Phosphatidylinositide phosphatase SAC1 OS=Mus musculus OX=10090 GN=Sacm1l PE=1 SV=1 0 13.986 7 3 4 3 587 66.9 7.3 3 4 1481611.188 2 metabolic process endoplasmic reticulum;Golgi;membrane catalytic activity;receptor activity;signal transducer activity Pf02383 83493 ENSMUSG00000025240.9 Sacm1l 9 Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane 0 High Q9JIX0 Transcription and mRNA export factor ENY2 OS=Mus musculus OX=10090 GN=Eny2 PE=1 SV=1 0 5.669 26 2 4 2 101 11.5 9.33 1 1 2 1 1 2 3075307.25 3501077.875 2565819.875 2547502 2 2 2 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport mitochondrion;nucleus Pf10163 223527 ENSMUSG00000022338.6 Eny2 15 0 High P68040 Receptor of activated protein C kinase 1 OS=Mus musculus OX=10090 GN=Rack1 PE=1 SV=3 0 10.713 14 2 4 2 317 35.1 7.69 1 1 2 1 1 2 127909.4844 436373.4844 473652.4219 1500404.313 1 2 2 2 cell death;cell differentiation;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome enzyme regulator activity;protein binding;receptor activity;RNA binding Pf00400 14694 ENSMUSG00000020372.15 Gnb2l1; Rack1 11 TNFR1-mediated ceramide production; TNFR1-induced NFkappaB signaling pathway; Regulation of TNFR1 signaling Measles 0 High Q7TN22 Thioredoxin domain-containing protein 16 OS=Mus musculus OX=10090 GN=Txndc16 PE=2 SV=1 0 8.161 4 3 4 3 820 92 5.31 3 4 1639641.375 1 cellular homeostasis;regulation of biological process endoplasmic reticulum;extracellular;organelle lumen "Pf00085, Pf13848" 70561 ENSMUSG00000021830.13 Txndc16 14 0 High Q91WD5 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs2 PE=1 SV=1" 0 10.026 8 3 4 3 463 52.6 6.99 3 4 719474.5 617666.0156 3192000.688 2 2 2 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00346 226646 ENSMUSG00000013593.12 Ndufs2 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High A2ALA4 Mediator of RNA polymerase II transcription subunit 22 (Fragment) OS=Mus musculus OX=10090 GN=Med22 PE=1 SV=1 0 4.923 14 2 4 2 168 19.6 5.12 1 1 2 1 1 2 403875.2188 1113850.375 983541.0625 1623306.75 1 1 2 2 metabolic process;regulation of biological process nucleus Pf06179 20933 ENSMUSG00000015776.12 Med22 2 0 High D3YVV0 Tetratricopeptide repeat domain 13 OS=Mus musculus OX=10090 GN=Ttc13 PE=1 SV=2 0 12.635 8 4 4 4 738 82.8 7.06 4 4 100225.1094 232930.0313 2149394.438 1 1 3 0 High Q8R1Q8 Cytoplasmic dynein 1 light intermediate chain 1 OS=Mus musculus OX=10090 GN=Dync1li1 PE=1 SV=1 0 8.891 11 4 4 4 523 56.6 6.42 4 4 587486.1094 567616.0625 714660.6563 3091380.781 2 2 2 3 cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport chromosome;cytoplasm;cytoskeleton;endosome;membrane;vacuole catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding "Pf00005, Pf05783, Pf10662" 235661 ENSMUSG00000032435.9 Dync1li1 9 COPI-mediated anterograde transport; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; COPI-independent Golgi-to-ER retrograde traffic; RHO GTPases Activate Formins; MHC class II antigen presentation Phagosome; Salmonella infection; Vasopressin-regulated water reabsorption 0 High Q9D8C6 Mediator of RNA polymerase II transcription subunit 11 OS=Mus musculus OX=10090 GN=Med11 PE=1 SV=1 0 9.214 32 2 4 2 117 13.1 5.96 1 1 2 1 1 2 295920.8125 408446 1561952.125 1 1 2 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf10280 66172 ENSMUSG00000018923.13 Med11 11 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High A0A1Y7VJH3 Apoptosis-stimulating of p53 protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Ppp1r13b PE=1 SV=1 0 5.275 2 2 4 2 964 104.4 7.23 1 2 1 1 2 1 44824.09375 1191734.75 1202376.781 1131299.188 1 2 2 2 cell death;regulation of biological process;response to stimulus protein binding "Pf00018, Pf00023, Pf02463, Pf07653, Pf10498, Pf11711, Pf12795, Pf12796, Pf13606, Pf13637, Pf13857, Pf13863, Pf14604, Pf15324" 0 High Q3UVK0 Endoplasmic reticulum metallopeptidase 1 OS=Mus musculus OX=10090 GN=Ermp1 PE=1 SV=2 0 10.041 4 3 4 3 898 100.1 7.49 3 4 1397271.5 2443110.766 2243556 4151632.469 1 1 1 3 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding "Pf04389, Pf14264" 226090 ENSMUSG00000046324.12 Ermp1 19 0 High Q5SWN2 Replication protein A subunit OS=Mus musculus OX=10090 GN=Rpa1 PE=1 SV=2 0 3.625 2 1 4 1 644 71.4 8.18 1 1 1 1 1 1 1 1 968691.0625 643664.9375 521484.2813 555689.4375 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;metal ion binding "Pf01336, Pf01485, Pf04057, Pf08646" 68275 ENSMUSG00000000751.13 Rpa1 11 0 High Q9DCA2 "28S ribosomal protein S11, mitochondrial OS=Mus musculus OX=10090 GN=Mrps11 PE=1 SV=2" 0 5.097 14 2 4 2 191 20.2 10.77 2 1 1 2 1 1 555966.3594 431834.0781 741041.8125 2 2 2 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00411 67994 Mrps11 7 0 High Q3U1J4 DNA damage-binding protein 1 OS=Mus musculus OX=10090 GN=Ddb1 PE=1 SV=2 0 11.388 3 1 4 1 1140 126.8 5.26 1 1 1 1 1 2 489462.8125 2200474.5 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding "Pf03178, Pf10433" 13194 ENSMUSG00000024740.9 Ddb1 19 Dual incision in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Hepatitis B; Nucleotide excision repair; Viral carcinogenesis 0 High Q9CQF9 Prenylcysteine oxidase OS=Mus musculus OX=10090 GN=Pcyox1 PE=1 SV=1 0 11.758 12 4 4 4 505 56.5 6.92 4 4 3105604.125 3 metabolic process;transport membrane;vacuole catalytic activity;transporter activity "Pf01266, Pf01593, Pf01946, Pf07156, Pf07992, Pf13450, Pf13454" 66881 ENSMUSG00000029998.14 Pcyox1 6 Terpenoid backbone biosynthesis 0 High O70472 Transmembrane protein 131 OS=Mus musculus OX=10090 GN=Tmem131 PE=2 SV=2 0 6.805 2 3 4 3 1877 204.5 8.54 3 4 185982.5313 2694550.188 1 3 membrane Pf12371 56030 ENSMUSG00000026116.11 Tmem131 1 0 Medium Q99LJ0 CTTNBP2 N-terminal-like protein OS=Mus musculus OX=10090 GN=Cttnbp2nl PE=1 SV=1 0.027 1.343 1 1 4 1 638 69.8 7.71 1 1 1 3 3959611.5 4341457.5 1586384 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton catalytic activity;motor activity;protein binding "Pf01576, Pf02463, Pf04111, Pf05483, Pf07888, Pf09727, Pf12128" 80281 ENSMUSG00000062127.11 Cttnbp2nl 3 0 High Q99JR5 Tubulointerstitial nephritis antigen-like OS=Mus musculus OX=10090 GN=Tinagl1 PE=1 SV=1 0 10.539 7 3 4 3 466 52.6 6.77 3 1 3 1 411930.5938 2068493.688 951098.1719 726665.25 2 2 2 1 metabolic process;response to stimulus;transport cytoplasm;extracellular;vacuole catalytic activity;protein binding;receptor activity "Pf00112, Pf01033" 94242 ENSMUSG00000028776.14 Tinagl1 4 0 High P61205 ADP-ribosylation factor 3 OS=Mus musculus OX=10090 GN=Arf3 PE=2 SV=2 0 14.307 24 4 4 3 181 20.6 7.43 4 4 253554.5156 195329.5156 3995063 1 1 3 regulation of biological process;response to stimulus;transport cytoplasm;Golgi catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 11842 ENSMUSG00000051853.9 Arf3 15 Synthesis of PIPs at the Golgi membrane Endocytosis 1 High D3YWY6 Mitochondrial pyruvate carrier OS=Mus musculus OX=10090 GN=Mpc1 PE=1 SV=1 0.001 2.193 9 1 4 1 85 9.7 9.39 1 1 1 1 1 2 182691.7813 589667 514125.4375 1252905 1 1 1 1 transport membrane;mitochondrion Pf03650 ENSMUSG00000023861.17 17 0 High P48758 Carbonyl reductase [NADPH] 1 OS=Mus musculus OX=10090 GN=Cbr1 PE=1 SV=3 0 6.416 10 2 4 2 277 30.6 8.31 1 1 2 1 1 2 296341.3594 430077.1563 440659.2813 764781.0313 2 2 2 2 Met-loss+Acetyl [N-Term] metabolic process cytoplasm;membrane;nucleus catalytic activity "Pf00106, Pf01370, Pf08659, Pf13561" 12408 ENSMUSG00000051483.8 Cbr1 16 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Metabolic pathways; Arachidonic acid metabolism; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 High Q78IK2 "ATP synthase membrane subunit DAPIT, mitochondrial OS=Mus musculus OX=10090 GN=Atp5md PE=1 SV=1" 0 14.751 47 3 4 3 58 6.4 9.83 3 4 105952.2969 171975.4844 245923.7031 5386416.25 1 1 1 3 Met-loss [N-Term] membrane;mitochondrion Pf14960 66477; 102642507 ENSMUSG00000071528.3 Usmg5; LOC100504912; LOC102642507 19; 4 0 High K3W4L3 Prosaposin OS=Mus musculus OX=10090 GN=Psap PE=1 SV=1 0 5.28 4 2 4 2 556 61.3 5.24 1 1 2 1 1 2 914851.6563 1882783.531 2173794.875 2061714.875 2 2 2 2 metabolic process vacuole "Pf02199, Pf03489, Pf05184" ENSMUSG00000004207.14 10 0 High Q9JKX6 ADP-sugar pyrophosphatase OS=Mus musculus OX=10090 GN=Nudt5 PE=1 SV=1 0 9.552 13 2 4 2 218 24 5.48 1 2 1 3 153574.2969 583349.3516 600953.9063 2411743.547 1 2 2 2 cell organization and biogenesis;metabolic process nucleus catalytic activity;metal ion binding;protein binding;RNA binding Pf00293 53893 ENSMUSG00000025817.12 Nudt5 2 Phosphate bond hydrolysis by NUDT proteins Purine metabolism 0 High Q9DC71 "28S ribosomal protein S15, mitochondrial OS=Mus musculus OX=10090 GN=Mrps15 PE=1 SV=2" 0 3.276 9 2 4 2 258 29.4 10.13 2 2 2 2 266526.5938 1112826.063 837527.6563 1264427.625 1 2 2 2 cell organization and biogenesis;metabolic process mitochondrion;nucleus;ribosome RNA binding;structural molecule activity Pf00312 66407 ENSMUSG00000028861.13 Mrps15 4 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High O35083 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Mus musculus OX=10090 GN=Agpat1 PE=1 SV=1 0 18.037 12 2 4 2 285 31.7 9.14 2 4 226077.6875 127028.793 2799938.938 2 2 2 metabolic process;regulation of biological process endoplasmic reticulum;membrane catalytic activity Pf01553 55979 Agpat1 17 Phospholipase D signaling pathway; Fat digestion and absorption; Metabolic pathways; Glycerophospholipid metabolism; Glycerolipid metabolism 0 High Q8BH64 EH domain-containing protein 2 OS=Mus musculus OX=10090 GN=Ehd2 PE=1 SV=1 0 3.854 3 2 4 1 543 61.1 6.51 2 2 2 2 368997.875 1336852.75 1429037.625 1752643.219 1 2 2 2 cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;endosome;membrane catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 259300 ENSMUSG00000074364.6 Ehd2 7 Factors involved in megakaryocyte development and platelet production Endocytosis 1 High P51660 Peroxisomal multifunctional enzyme type 2 OS=Mus musculus OX=10090 GN=Hsd17b4 PE=1 SV=3 0 7.71 5 3 4 3 735 79.4 8.57 2 1 2 2 1361032.719 1243986.375 873739.6406 921645.875 3 3 3 3 cell differentiation;metabolic process membrane;mitochondrion catalytic activity;protein binding "Pf00106, Pf01575, Pf02036, Pf08659, Pf13452, Pf13561, Pf14864" 15488 ENSMUSG00000024507.6 Hsd17b4 18 Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism Metabolic pathways; Primary bile acid biosynthesis; Peroxisome 0 High P58854 Gamma-tubulin complex component 3 OS=Mus musculus OX=10090 GN=Tubgcp3 PE=1 SV=2 0 10.199 4 3 4 3 905 103.4 8.32 1 3 1 3 232232.8125 278941.3516 445346.8828 1434462.781 2 2 3 3 cell organization and biogenesis cytoplasm;cytoskeleton;membrane protein binding;structural molecule activity Pf04130 259279 ENSMUSG00000000759.14 Tubgcp3 8 Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes 0 High P70168 Importin subunit beta-1 OS=Mus musculus OX=10090 GN=Kpnb1 PE=1 SV=2 0 6.896 2 2 4 2 876 97.1 4.78 1 1 2 1 1 2 139978.9375 117541.4141 127432.5703 617296.7188 1 1 1 2 Acetyl [N-Term] cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus protein binding;RNA binding;transporter activity "Pf02985, Pf03810, Pf13513" 16211 ENSMUSG00000001440.5 Kpnb1 11 Activation of DNA fragmentation factor; Neutrophil degranulation; Regulation of cholesterol biosynthesis by SREBP (SREBF) RNA transport 0 Medium G5E866 Splicing factor 3B subunit 1 OS=Mus musculus OX=10090 GN=Sf3b1 PE=1 SV=1 0.012 1.824 1 1 4 1 1304 145.7 7.09 1 1 1 1 1 1 1 1 432588.875 585308.375 1092341.875 396158.6563 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus;spliceosomal complex DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity "Pf02161, Pf08920, Pf12815, Pf13513" 81898 ENSMUSG00000025982.13 Sf3b1 1 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; B-WICH complex positively regulates rRNA expression Spliceosome 0 High Q61292 Laminin subunit beta-2 OS=Mus musculus OX=10090 GN=Lamb2 PE=1 SV=2 0 11.1 2 3 4 3 1799 196.5 6.67 3 4 1650373.328 2762783 1906468.219 3636594.5 3 3 3 4 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;extracellular protein binding "Pf00053, Pf00055, Pf00769, Pf01442, Pf04012, Pf06008, Pf07111, Pf11740, Pf12128, Pf13514, Pf14662, Pf15558" 16779 ENSMUSG00000052911.9 Lamb2 9 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); MET activates PTK2 signaling; Laminin interactions; Post-translational protein phosphorylation Focal adhesion; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q8JZX4 Splicing factor 45 OS=Mus musculus OX=10090 GN=Rbm17 PE=1 SV=1 0 10.118 17 4 4 4 405 45.3 5.82 1 2 1 1 2 1 972893.6719 2039714.156 796776.125 3715812.813 2 3 2 2 metabolic process;regulation of biological process;response to stimulus nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf01585, Pf13893, Pf14259" 76938 ENSMUSG00000037197.11 Rbm17 2 mRNA Splicing - Major Pathway Spliceosome 0 High Q792Z1 Trypsin 10 OS=Mus musculus OX=10090 GN=Try10 PE=1 SV=1 0 2.509 4 1 4 1 246 26.2 5.83 1 1 1 1 1 1 1 1 750704.125 1327709.625 1258302.25 1037459.438 1 1 1 1 metabolic process catalytic activity Pf00089 436522 ENSMUSG00000071521.4 Try10 6 "Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation; Collagen degradation; Antimicrobial peptides; Activation of Matrix Metalloproteinases" Pancreatic secretion; Protein digestion and absorption; Influenza A; Neuroactive ligand-receptor interaction 0 High Q9CW03 Structural maintenance of chromosomes protein 3 OS=Mus musculus OX=10090 GN=Smc3 PE=1 SV=2 0 4.391 3 4 4 4 1217 141.5 7.18 4 4 155200.0469 158715.5781 170251.7344 1185289.781 1 1 1 3 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport chromosome;nucleus nucleotide binding;protein binding;transporter activity "Pf01496, Pf02463, Pf04111, Pf06470, Pf10168, Pf12128, Pf13304, Pf13476, Pf13555" 13006 ENSMUSG00000024974.10 Smc3 19 Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Meiotic Synapsis; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Mus musculus biological processes; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 High Q9CQU0 Thioredoxin domain-containing protein 12 OS=Mus musculus OX=10090 GN=Txndc12 PE=1 SV=1 0 8.41 18 3 4 3 170 19 5.26 3 4 186781.75 192561.5938 2641422.625 1 1 3 cell differentiation;cellular homeostasis;metabolic process;regulation of biological process endoplasmic reticulum;organelle lumen catalytic activity "Pf00085, Pf13098, Pf13899" 66073 ENSMUSG00000028567.8 Txndc12 4 Glutathione metabolism 0 High Q9JMG2 C1GALT1-specific chaperone 1 OS=Mus musculus OX=10090 GN=C1galt1c1 PE=2 SV=1 0 9.387 12 3 3 3 316 36 6.74 3 3 3073561.938 3 cell organization and biogenesis;metabolic process;regulation of biological process membrane catalytic activity 59048 ENSMUSG00000048970.9 C1galt1c1 X O-linked glycosylation of mucins Metabolic pathways; Mucin type O-glycan biosynthesis 0 High Q8R4N0 "Citramalyl-CoA lyase, mitochondrial OS=Mus musculus OX=10090 GN=Clybl PE=1 SV=2" 0 11.66 14 3 3 3 338 37.5 8.54 3 3 mitochondrion catalytic activity;metal ion binding "Pf03328, Pf15617" 69634 ENSMUSG00000025545.9 Clybl 14 0 High Q5RL20 "39S ribosomal protein L43, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl43 PE=1 SV=1" 0.004 2.141 7 1 3 1 159 17.9 10.58 1 1 1 1 1 1 173491.1172 536965.9375 445918.0625 737089.6563 1 1 1 1 metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf05047 94067 ENSMUSG00000025208.8 Mrpl43 19 Mitochondrial translation termination; Mitochondrial translation elongation 0 High A0A0G2JGD2 Protein S100-A4 (Fragment) OS=Mus musculus OX=10090 GN=S100a4 PE=1 SV=1 0 4.516 23 1 3 1 78 9.1 5.21 1 1 1 1 1 1 134479.5781 126575.7734 254601.7344 1 1 1 Met-loss+Acetyl [N-Term] metal ion binding;protein binding Pf01023 ENSMUSG00000001020.8 3 0 High Q91YH5 Atlastin-3 OS=Mus musculus OX=10090 GN=Atl3 PE=1 SV=1 0 7.75 7 3 3 3 541 60.5 6.1 3 3 118114.6094 142877.125 1239191.156 1 1 2 cell organization and biogenesis;regulation of biological process endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding Pf02263 109168 ENSMUSG00000024759.13 Atl3 19 0 High Q8BVY0 Ribosomal L1 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Rsl1d1 PE=1 SV=1 0 2.237 4 1 3 1 452 50.4 9.98 1 1 1 1 1 1 1068544.25 2160922.75 1876546.25 1013394.875 1 1 1 1 cell differentiation;metabolic process;regulation of biological process membrane;nucleus protein binding;RNA binding Pf00687 66409 ENSMUSG00000005846.11 Rsl1d1 16 0 High Q6P6J9 Thioredoxin domain-containing protein 15 OS=Mus musculus OX=10090 GN=Txndc15 PE=1 SV=1 0 6.835 8 2 3 2 344 38.1 4.77 2 3 219779.375 122232.2266 5188030.875 1 1 2 cellular homeostasis;regulation of biological process membrane Pf00085 69672 ENSMUSG00000021497.9 Txndc15 13 0 High Q6XLQ8 Calumenin OS=Mus musculus OX=10090 GN=Calu PE=1 SV=1 0 2.835 6 2 3 2 315 37.1 4.59 2 3 93650.52344 242830.7969 246905.8125 2436506.375 1 1 1 2 endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen enzyme regulator activity;metal ion binding;protein binding Pf13499 12321 ENSMUSG00000029767.16 Calu 6 0 High A0A571BDM4 AP2-associated protein kinase 1 (Fragment) OS=Mus musculus OX=10090 GN=Aak1 PE=1 SV=1 0 4.998 13 2 3 1 237 25.2 8.66 2 1 2 1 0 High Q3UXL9 Cyclin-C OS=Mus musculus OX=10090 GN=Ccnc PE=1 SV=1 0 4.061 6 2 3 2 266 31.5 7.93 1 1 1 1 1 1 268265.4063 689204.25 545531.8125 1259584.625 1 1 1 1 metabolic process;regulation of biological process nucleus catalytic activity;enzyme regulator activity Pf00134 51813 ENSMUSG00000028252.20 Ccnc 4 0 High F6RDI8 Serine and arginine-rich-splicing factor 11 (Fragment) OS=Mus musculus OX=10090 GN=Srsf11 PE=1 SV=1 0 4.017 3 1 3 1 500 55.8 10.61 1 1 1 1 1 1 230091.4688 468614.125 417551.75 498930.5 1 1 1 1 metabolic process RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000055436.18 3 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript 0 High H7BWY7 RBR-type E3 ubiquitin transferase OS=Mus musculus OX=10090 GN=Arih1 PE=1 SV=1 0 5.493 7 2 3 2 381 42.5 4.79 2 1 2 1 884109.0313 798774.6719 179975.4688 2 2 1 metabolic process catalytic activity;metal ion binding "Pf01485, Pf13923" ENSMUSG00000025234.11 9 0 Medium A0A571BF69 Maltase-glucoamylase OS=Mus musculus OX=10090 GN=Mgam PE=1 SV=1 0.034 1.171 0 1 3 1 3616 412.8 5.68 1 1 1 1 1 1 596152 1041161.438 1095358.375 703627.1875 1 1 1 1 0 High Q62318 Transcription intermediary factor 1-beta OS=Mus musculus OX=10090 GN=Trim28 PE=1 SV=3 0 6.956 2 1 3 1 834 88.8 5.77 1 1 1 1 1 1 122740.7891 299212.125 809038.3438 689074.4688 1 1 2 2 cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding "Pf00628, Pf00643" 21849 ENSMUSG00000005566.14 Trim28 7 Generic Transcription Pathway 0 Medium Q61733 "28S ribosomal protein S31, mitochondrial OS=Mus musculus OX=10090 GN=Mrps31 PE=1 SV=1" 0.02 1.573 2 1 3 1 384 43.9 8.51 1 1 1 2 35833.875 331787.5313 227530.7344 336963.5 1 1 1 1 mitochondrion;ribosome protein binding;RNA binding;structural molecule activity Pf15433 57312 ENSMUSG00000031533.4 Mrps31 8 Mitochondrial translation termination; Mitochondrial translation elongation 0 High P03953 Complement factor D OS=Mus musculus OX=10090 GN=Cfd PE=1 SV=1 0 5.756 11 2 3 2 259 28 6.67 1 2 1 2 476435.6875 5864309.5 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular catalytic activity "Pf00089, Pf09342" 11537 ENSMUSG00000061780.6 Cfd 10 Alternative complement activation; Platelet degranulation ; Neutrophil degranulation Staphylococcus aureus infection; Complement and coagulation cascades 0 High Q9Z2N8 Actin-like protein 6A OS=Mus musculus OX=10090 GN=Actl6a PE=1 SV=2 0 3.696 7 2 3 2 429 47.4 5.6 1 1 1 1 1 1 4319629.5 8872392.531 7220159.688 6564100 2 2 2 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus DNA binding;protein binding Pf00022 56456 ENSMUSG00000027671.14 Actl6a 3 DNA Damage Recognition in GG-NER; RMTs methylate histone arginines; UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 High Q9WVK4 EH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Ehd1 PE=1 SV=1 0 3.849 4 2 3 1 534 60.6 6.83 1 1 1 1 1 1 161356 152310.9688 314912.2188 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endosome;membrane metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 13660 ENSMUSG00000024772.9; ENSMUSG00000107039.1 Ehd1 19; CHR_MG4249_PATCH Factors involved in megakaryocyte development and platelet production Endocytosis 0 High Q9CQ60 6-phosphogluconolactonase OS=Mus musculus OX=10090 GN=Pgls PE=1 SV=1 0 6.565 9 2 3 2 257 27.2 5.85 2 3 157071.1563 712559.625 1 1 metabolic process cytoplasm catalytic activity Pf01182 66171 ENSMUSG00000031807.10 Pgls 8 Pentose phosphate pathway (hexose monophosphate shunt) Metabolic pathways; Pentose phosphate pathway; Carbon metabolism 0 High P61620 Protein transport protein Sec61 subunit alpha isoform 1 OS=Mus musculus OX=10090 GN=Sec61a1 PE=1 SV=2 0 5.456 4 2 3 2 476 52.2 8.06 2 3 108689.3906 256058.8906 11340016.5 1 1 2 cell growth;cell organization and biogenesis;development;response to stimulus;transport endoplasmic reticulum;membrane transporter activity "Pf00344, Pf10559" 53421 ENSMUSG00000030082.14 Sec61a1 6 XBP1(S) activates chaperone genes Phagosome; Protein export; Protein processing in endoplasmic reticulum 0 High A0A1B0GS70 Proteasome endopeptidase complex OS=Mus musculus OX=10090 GN=Psma1 PE=1 SV=1 0 3.354 8 2 3 2 238 26.5 6.54 1 2 1 2 2433889.5 1856085.031 2766480.25 1 2 2 metabolic process;regulation of biological process cytoplasm;nucleus;proteasome catalytic activity;protein binding Pf00227 26440 ENSMUSG00000030751.18 Psma1 7 0 High Q91ZP3 Phosphatidate phosphatase LPIN1 OS=Mus musculus OX=10090 GN=Lpin1 PE=1 SV=1 0 8.416 5 3 3 3 924 101.9 6.74 3 3 80555.28125 2151537.688 1 3 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf04571, Pf08235, Pf15017" 14245 Lpin1 12 mTOR signaling pathway; Metabolic pathways; Glycerophospholipid metabolism; Glycerolipid metabolism 0 High Q60714 Long-chain fatty acid transport protein 1 OS=Mus musculus OX=10090 GN=Slc27a1 PE=1 SV=1 0 5.713 9 3 3 3 646 71.2 8.38 3 3 2763338.75 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;transporter activity "Pf00501, Pf13193" 26457 ENSMUSG00000031808.7 Slc27a1 8 Transport of fatty acids PPAR signaling pathway; Insulin resistance 0 High R4H4V1 N-terminal kinase-like protein OS=Mus musculus OX=10090 GN=Scyl1 PE=1 SV=1 0 5.708 3 3 3 3 749 82.4 6.25 3 3 85150.51563 89369.72656 1893134.563 1 1 3 metabolic process;transport cytoplasm;cytoskeleton;cytosol;Golgi;membrane catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 78891 Scyl1 19 0 High Q62376 U1 small nuclear ribonucleoprotein 70 kDa OS=Mus musculus OX=10090 GN=Snrnp70 PE=1 SV=2 0 5.588 7 2 3 2 448 52 9.94 1 2 1 2 213453.4063 623108 950541.1875 739875.5625 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus;spliceosomal complex RNA binding "Pf00076, Pf12220, Pf13893, Pf14259" 20637 ENSMUSG00000063511.11 Snrnp70 7 mRNA Splicing - Major Pathway Spliceosome 0 High Q64310 Surfeit locus protein 4 OS=Mus musculus OX=10090 GN=Surf4 PE=1 SV=1 0 14.268 11 2 3 2 269 30.4 7.78 1 1 1 2 363344.8359 412066.2188 2707056.375 2 1 2 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process endoplasmic reticulum;Golgi;membrane protein binding Pf02077 20932 ENSMUSG00000014867.9 Surf4 2 COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation 0 High Q3UJB0 "Splicing factor 3b, subunit 2 OS=Mus musculus OX=10090 GN=Sf3b2 PE=1 SV=1" 0 6.072 4 3 3 3 878 98.1 5.62 1 1 1 1 1 1 807452.0938 1349188.188 781425.5 881989.5313 2 3 3 2 metabolic process nucleus;spliceosomal complex protein binding;RNA binding "Pf02037, Pf04037, Pf04046" 319322 ENSMUSG00000024853.9 Sf3b2 19 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 High P05132 cAMP-dependent protein kinase catalytic subunit alpha OS=Mus musculus OX=10090 GN=Prkaca PE=1 SV=3 0 2.462 5 1 3 1 351 40.5 8.79 1 1 1 1 1 1 456674.9375 277712.8125 285863.6875 339799.125 1 1 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;Golgi;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 18747 ENSMUSG00000005469.10 Prkaca 8 "Loss of Nlp from mitotic centrosomes; Recruitment of NuMA to mitotic centrosomes; Rap1 signalling; MAPK6/MAPK4 signaling; Ion homeostasis; CD209 (DC-SIGN) signaling; GLI3 is processed to GLI3R by the proteasome; Vasopressin regulates renal water homeostasis via Aquaporins; Interleukin-3, 5 and GM-CSF signaling; PKA activation; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Recruitment of mitotic centrosome proteins and complexes; Signaling by GPCR; Regulation of PLK1 Activity at G2/M Transition; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; HDL assembly; PKA activation in glucagon signalling; DARPP-32 events; Factors involved in megakaryocyte development and platelet production" Oxytocin signaling pathway; Morphine addiction; Wnt signaling pathway; Cholinergic synapse; Retrograde endocannabinoid signaling; MAPK signaling pathway; Dopaminergic synapse; Progesterone-mediated oocyte maturation; Ras signaling pathway; GABAergic synapse; Regulation of lipolysis in adipocytes; Ovarian steroidogenesis; Insulin signaling pathway; Long-term potentiation; Epstein-Barr virus infection; Chemokine signaling pathway; Amphetamine addiction; Endocrine and other factor-regulated calcium reabsorption; Platelet activation; Melanogenesis; Dilated cardiomyopathy; HTLV-I infection; Thyroid hormone synthesis; Oocyte meiosis; Longevity regulating pathway; Glutamatergic synapse; Proteoglycans in cancer; Parkinson's disease; Thyroid hormone signaling pathway; Cocaine addiction; Taste transduction; Pathways in cancer; Calcium signaling pathway; Bile secretion; Salivary secretion; Hedgehog signaling pathway; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Vasopressin-regulated water reabsorption; Olfactory transduction; Gastric acid secretion; Prion diseases; Renin secretion; Gap junction; Circadian entrainment; Insulin secretion; Estrogen signaling pathway; Amoebiasis; Glucagon signaling pathway; Viral carcinogenesis; Serotonergic synapse; Adrenergic signaling in cardiomyocytes; Longevity regulating pathway - multiple species; Endocrine resistance; Inflammatory mediator regulation of TRP channels 0 High Q9CZ13 "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Mus musculus OX=10090 GN=Uqcrc1 PE=1 SV=2" 0 5.505 5 2 3 2 480 52.8 6.21 1 1 1 1 1 1 611254.75 990987.25 1 1 metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00675, Pf05193, Pf08367" 22273 ENSMUSG00000025651.14; ENSMUSG00000107235.3 Uqcrc1 9; CHR_MG117_PATCH Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q9CQI9 Mediator of RNA polymerase II transcription subunit 30 OS=Mus musculus OX=10090 GN=Med30 PE=1 SV=1 0 4.4 7 1 3 1 178 20.3 8.28 1 1 1 1 1 1 699385.3125 626220.6875 1334892.875 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;protein binding;receptor activity Pf11315 69790 ENSMUSG00000038622.7 Med30 15 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Thyroid hormone signaling pathway 0 High G3UVU6 Mediator of RNA polymerase II transcription subunit 20 OS=Mus musculus OX=10090 GN=Gm20517 PE=3 SV=1 0 6.87 24 2 3 2 152 16.5 8 1 2 1 2 186490.6719 741360.375 572803.625 918397.125 1 1 1 1 regulation of biological process Pf08612 ENSMUSG00000023984.17 17 Generic Transcription Pathway 0 High Q9R1Q9 V-type proton ATPase subunit S1 OS=Mus musculus OX=10090 GN=Atp6ap1 PE=1 SV=1 0 8.304 7 2 3 2 463 51 5.92 2 3 1132295.875 1 cell death;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;transporter activity Pf05827 54411 ENSMUSG00000019087.13 Atp6ap1 X Ion channel transport; Transferrin endocytosis and recycling; Insulin receptor recycling Rheumatoid arthritis; Metabolic pathways; Tuberculosis; Hepatitis B; Lysosome; Phagosome; Oxidative phosphorylation 0 High A0A338P731 40S ribosomal protein S10 (Fragment) OS=Mus musculus OX=10090 GN=Rps10 PE=1 SV=1 0 3.432 8 1 3 1 107 12.8 10.04 1 1 1 1 1 1 813894.375 1 0 High Q9D8T7 "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Mus musculus OX=10090 GN=Slirp PE=1 SV=2" 0 2.87 10 1 3 1 112 12.6 9.82 1 1 1 1 1 1 532427.4375 418786.8125 762468.5 1 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process cytoplasm;mitochondrion;nucleus RNA binding "Pf00076, Pf05172, Pf13893, Pf14259" 380773 ENSMUSG00000021040.15 Slirp 12 0 High Q9D023 Mitochondrial pyruvate carrier 2 OS=Mus musculus OX=10090 GN=Mpc2 PE=1 SV=1 0 7.125 18 2 3 2 127 14.3 10.61 2 3 186084.75 169823.3125 685464.375 1 1 1 regulation of biological process;transport membrane;mitochondrion;nucleus transporter activity Pf03650 70456 ENSMUSG00000026568.6 Mpc2 1 0 High Q80X85 "28S ribosomal protein S7, mitochondrial OS=Mus musculus OX=10090 GN=Mrps7 PE=1 SV=1" 0 7.399 7 1 3 1 242 28 9.94 1 1 1 1 1 1 656990 540330.125 871338.5 1 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00177 50529 ENSMUSG00000046756.10 Mrps7 11 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High F6V8M6 Ataxin-2 (Fragment) OS=Mus musculus OX=10090 GN=Atxn2 PE=1 SV=2 0 8.14 2 1 3 1 662 70.4 9.44 1 1 1 1 1 1 467345.5938 590091.1875 752307.6875 736010.125 1 1 1 1 "Pf07145, Pf09770" ENSMUSG00000042605.15 5 0 High P47738 "Aldehyde dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Aldh2 PE=1 SV=1" 0 3.81 2 1 3 1 519 56.5 7.62 1 1 1 1 1 1 207868.4688 867068.0625 985468.9375 797096 1 1 1 1 metabolic process;regulation of biological process mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding Pf00171 11669 ENSMUSG00000029455.14 Aldh2 5 Metabolism of serotonin; Ethanol oxidation "Histidine metabolism; Pyruvate metabolism; Arginine and proline metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Glycolysis / Gluconeogenesis; beta-Alanine metabolism; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Pentose and glucuronate interconversions" 0 High Q00PI9 Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Mus musculus OX=10090 GN=Hnrnpul2 PE=1 SV=2 0 4.946 3 2 3 2 745 84.9 4.89 1 1 1 1 1 1 286456.75 1961889.438 1543445.063 2671607.25 1 2 2 2 membrane;nucleus protein binding;RNA binding "Pf00622, Pf02037, Pf13671" 68693 ENSMUSG00000071659.3 Hnrnpul2 19 0 High Q78JE5 F-box only protein 22 OS=Mus musculus OX=10090 GN=Fbxo22 PE=1 SV=2 0 5.069 6 2 3 2 402 44.2 7.61 2 1 2 1 318536.3125 342209.25 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;nucleus catalytic activity;protein binding "Pf00646, Pf10442, Pf12937" 71999 ENSMUSG00000032309.15 Fbxo22 9 Neddylation; Antigen processing: Ubiquitination & Proteasome degradation 0 High Q9EPR2 Group XIIA secretory phospholipase A2 OS=Mus musculus OX=10090 GN=Pla2g12a PE=1 SV=2 0 10.711 19 2 3 2 192 21.3 7.15 2 3 170119.9688 97472.14063 844154.9688 1 1 1 metabolic process;transport cytoplasm;endoplasmic reticulum;extracellular;Golgi catalytic activity;metal ion binding Pf06951 66350 ENSMUSG00000027999.15 Pla2g12a 3 Acyl chain remodelling of PI; Acyl chain remodelling of PG; Acyl chain remodelling of PC; Synthesis of PA; Acyl chain remodelling of PS; Acyl chain remodelling of PE Pancreatic secretion; Ras signaling pathway; Fat digestion and absorption; Metabolic pathways; Linoleic acid metabolism; Ether lipid metabolism; Glycerophospholipid metabolism; alpha-Linolenic acid metabolism; Vascular smooth muscle contraction; Arachidonic acid metabolism 0 High A2ATP6 Myelin expression factor 2 OS=Mus musculus OX=10090 GN=Myef2 PE=1 SV=2 0 3.591 2 1 3 1 567 61.1 8.75 1 1 1 1 1 1 675228.5625 1 regulation of biological process nucleus DNA binding;RNA binding "Pf00076, Pf11608, Pf13893, Pf14259" 17876 ENSMUSG00000027201.16 Myef2 2 0 High P84091 AP-2 complex subunit mu OS=Mus musculus OX=10090 GN=Ap2m1 PE=1 SV=1 0 5.937 6 3 3 3 435 49.6 9.54 1 2 1 2 394740.2969 274104.3125 230026.4844 916316.8438 2 1 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport membrane;mitochondrion protein binding Pf00928 11773 ENSMUSG00000022841.14 Ap2m1 16 "WNT5A-dependent internalization of FZD4; Trafficking of GluR2-containing AMPA receptors; VLDLR internalisation and degradation; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance" Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Huntington's disease; Synaptic vesicle cycle 0 High D3YVC9 Graves disease carrier protein homolog (Fragment) OS=Mus musculus OX=10090 GN=Slc25a16 PE=1 SV=1 0 9.253 9 3 3 3 322 34.9 9.95 3 3 2279474.063 3 transport membrane;mitochondrion Pf00153 ENSMUSG00000071253.8 10 0 High P14142 "Solute carrier family 2, facilitated glucose transporter member 4 OS=Mus musculus OX=10090 GN=Slc2a4 PE=1 SV=3" 0 6.089 5 2 3 2 509 54.7 8.13 2 3 236141.5781 3536949.25 1 2 cell differentiation;metabolic process;response to stimulus;transport cell surface;cytoplasm;cytosol;endosome;membrane protein binding;transporter activity "Pf00083, Pf07690" 20528 ENSMUSG00000018566.14 Slc2a4 11 Cellular hexose transport FoxO signaling pathway; Type II diabetes mellitus; Insulin signaling pathway; Insulin resistance; Adipocytokine signaling pathway; AMPK signaling pathway 0 High Q91UZ5 Inositol monophosphatase 2 OS=Mus musculus OX=10090 GN=Impa2 PE=1 SV=1 0 6.951 8 2 3 2 290 31.7 6.23 2 3 77392.0625 219130.4844 226642.8594 2261898 1 1 1 2 metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;metal ion binding;protein binding Pf00459 114663 ENSMUSG00000024525.6 Impa2 18 "Synthesis of IP2, IP, and Ins in the cytosol" Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system 0 High Q99LC3 "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Mus musculus OX=10090 GN=Ndufa10 PE=1 SV=1" 0 8.63 7 2 3 2 355 40.6 7.78 1 2 1 2 225958.3906 430760.2266 1168671.188 1 2 2 cell organization and biogenesis;metabolic process;transport mitochondrion;organelle lumen catalytic activity "Pf01712, Pf02223" 67273 ENSMUSG00000026260.12 Ndufa10 1 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Medium Q3UEB3 Poly(U)-binding-splicing factor PUF60 OS=Mus musculus OX=10090 GN=Puf60 PE=1 SV=2 0.013 1.795 1 1 3 1 564 60.2 5.29 1 1 1 1 1 1 245310.8594 577907.8125 445690.3438 618774 1 1 1 1 cell death;metabolic process;regulation of biological process nucleus DNA binding;protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 67959 ENSMUSG00000002524.15 Puf60 15 mRNA Splicing - Major Pathway Spliceosome 0 High Q9CWY4 Gem-associated protein 7 OS=Mus musculus OX=10090 GN=Gemin7 PE=2 SV=1 0 2.717 12 1 3 1 129 14.2 7.52 1 1 1 1 1 1 46960.57031 273300.1563 150871.7969 362870.375 1 1 1 1 Acetyl [N-Term] cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus protein binding Pf11095 69731 ENSMUSG00000044709.6 Gemin7 7 snRNP Assembly RNA transport 0 High Q61585 G0/G1 switch protein 2 OS=Mus musculus OX=10090 GN=G0s2 PE=1 SV=1 0 9.404 20 2 3 2 103 11.1 8.32 2 3 449394 494954.6875 11855361 1 1 2 cell death;regulation of biological process;response to stimulus membrane;mitochondrion Pf15103 14373 ENSMUSG00000009633.3 G0s2 1 0 High A0A0A6YWC8 Vimentin OS=Mus musculus OX=10090 GN=Vim PE=1 SV=1 0.001 2.211 3 1 3 1 427 49.2 5.12 1 1 1 1 1 1 436731.8438 352823.4688 263885.1563 1 1 1 metabolic process;regulation of biological process structural molecule activity "Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186" ENSMUSG00000026728.9 2 0 High Q9Z110 Delta-1-pyrroline-5-carboxylate synthase OS=Mus musculus OX=10090 GN=Aldh18a1 PE=1 SV=2 0 11.327 6 3 3 3 795 87.2 7.55 3 3 501520.8438 195343.7031 2124712.375 2 1 3 metabolic process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00171, Pf00696" 56454 ENSMUSG00000025007.13 Aldh18a1 19 Amino acid synthesis and interconversion (transamination) Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids 0 High Q9D7S7 60S ribosomal protein L22-like 1 OS=Mus musculus OX=10090 GN=Rpl22l1 PE=1 SV=1 0 11.908 39 3 3 3 122 14.5 9.45 2 1 2 1 1724174.563 2894565.25 2066801.875 803854.375 2 2 1 1 metabolic process ribosome RNA binding;structural molecule activity Pf01776 68028 ENSMUSG00000039221.10 Rpl22l1 3 Ribosome 0 High Q8K4Q0 Regulatory-associated protein of mTOR OS=Mus musculus OX=10090 GN=Rptor PE=1 SV=1 0 13.531 4 3 3 3 1335 149.4 6.87 3 3 1634125.563 2 cell communication;cell growth;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;vacuole DNA binding;enzyme regulator activity;protein binding "Pf01602, Pf12717, Pf13646, Pf14538" 74370 Rptor 11 0 Medium Q921D4 Mediator of RNA polymerase II transcription subunit 6 OS=Mus musculus OX=10090 GN=Med6 PE=1 SV=2 0.021 1.548 4 1 3 1 246 28.4 8.62 1 1 1 1 1 1 74205.41406 514970.9688 341629.375 540091.1875 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process membrane;nucleus catalytic activity;DNA binding;protein binding Pf04934 69792 ENSMUSG00000002679.14 Med6 12 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High Q9CR80 Protein FAM32A OS=Mus musculus OX=10090 GN=Fam32a PE=2 SV=1 0 3.148 20 2 3 2 112 13.2 9.94 2 3 1088453.563 415829.6563 904043.2188 641807.3906 2 1 2 2 Acetyl [N-Term] cell death nucleus RNA binding 67922 ENSMUSG00000003039.9 Fam32a 8 0 High Q8CCM0 Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Mus musculus OX=10090 GN=Camk2d PE=1 SV=1 0 4.749 8 2 3 2 361 40.7 7.78 1 2 1 2 105972.5313 373985.2813 358449.375 548926.0625 1 1 1 1 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00069, Pf07714" 108058 ENSMUSG00000053819.16 Camk2d 3 0 High Q9CXY6 Interleukin enhancer-binding factor 2 OS=Mus musculus OX=10090 GN=Ilf2 PE=1 SV=1 0 3.593 7 2 3 2 390 43 5.26 2 1 2 1 193048.5781 1074169.688 868172.1875 473160.2813 1 2 2 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;extracellular;membrane;nucleus catalytic activity;DNA binding;nucleotide binding;RNA binding Pf07528 67781 ENSMUSG00000001016.12 Ilf2 3 Neutrophil degranulation 0 High Q03963 "Interferon-induced, double-stranded RNA-activated protein kinase OS=Mus musculus OX=10090 GN=Eif2ak2 PE=1 SV=2" 0 4.91 6 2 3 2 515 58.2 8.57 2 1 2 1 655724.1875 1483200.25 1189523.5 777226.1875 1 2 2 1 cell communication;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00035, Pf00069, Pf07714" 19106 ENSMUSG00000024079.4 Eif2ak2 17 Herpes simplex infection; Epstein-Barr virus infection; Influenza A; Hepatitis C; Protein processing in endoplasmic reticulum; Viral carcinogenesis; Measles 0 High Q8VDM4 26S proteasome non-ATPase regulatory subunit 2 OS=Mus musculus OX=10090 GN=Psmd2 PE=1 SV=1 0 10.883 5 3 3 3 908 100.1 5.17 3 3 747521.9375 1477702.25 1 2 metabolic process;regulation of biological process membrane;nucleus;proteasome catalytic activity;enzyme regulator activity;protein binding Pf01851 21762 ENSMUSG00000006998.15 Psmd2 16 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High P47955 60S acidic ribosomal protein P1 OS=Mus musculus OX=10090 GN=Rplp1 PE=1 SV=1 0 13.569 75 3 3 3 114 11.5 4.32 3 3 5305218.188 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process ribosome enzyme regulator activity;structural molecule activity Pf00428 56040 ENSMUSG00000007892.8 Rplp1 9 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8BMK4 Cytoskeleton-associated protein 4 OS=Mus musculus OX=10090 GN=Ckap4 PE=1 SV=2 0 2.822 2 1 3 1 575 63.7 5.64 1 1 1 1 1 1 710078.9375 572819 681620.3125 897614.875 1 1 1 1 cell surface;cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane RNA binding Pf13166 216197 ENSMUSG00000046841.5 Ckap4 10 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation; Post-translational protein phosphorylation; Surfactant metabolism Protein processing in endoplasmic reticulum 0 High H7BX99 Prothrombin OS=Mus musculus OX=10090 GN=F2 PE=1 SV=1 0 2.804 1 1 3 1 617 70.2 6.43 1 1 1 1 1 1 70390.03125 237411.8125 260788.9688 367104.4688 1 1 1 1 coagulation;defense response;metabolic process;regulation of biological process;response to stimulus extracellular catalytic activity;metal ion binding "Pf00051, Pf00089, Pf00594, Pf09342, Pf09396" ENSMUSG00000027249.15 2 0 Medium A0A0A0MQM2 Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch1 PE=1 SV=1 0.022 1.468 1 1 3 1 1073 122.5 7.72 1 3 71053408 1 metabolic process;regulation of biological process;response to stimulus catalytic activity;metal ion binding;protein binding;signal transducer activity "Pf00036, Pf00168, Pf00387, Pf00388, Pf09279, Pf13499, Pf14788" ENSMUSG00000036834.16 3 0 High D3Z1U9 "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus OX=10090 GN=Ndufv1 PE=1 SV=1" 0 13.773 12 3 3 3 385 41.8 6.96 3 3 2837011.5 3 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf01512, Pf10531, Pf10589" ENSMUSG00000037916.13 19 0 High Q8CB77 Elongin-A OS=Mus musculus OX=10090 GN=Eloa PE=1 SV=3 0 4.62 2 1 3 1 773 87.1 9.61 1 1 1 1 1 1 189555.6094 287175.0625 225978.0625 649211.4063 1 1 1 2 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process nucleus DNA binding;protein binding "Pf06881, Pf08711" 27224 ENSMUSG00000028668.5 Tceb3; Eloa 4 RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex 0 High Q9QUK9 TESP4 OS=Mus musculus OX=10090 GN=Try5 PE=1 SV=1 0 4.311 12 2 3 1 246 26.3 5.3 1 1 1 1 1 1 750704.125 1327709.625 1258302.25 1037459.438 1 1 1 1 metabolic process catalytic activity;metal ion binding Pf00089 103964 ENSMUSG00000036938.17 Try5 6 "Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation; Collagen degradation; Antimicrobial peptides; Activation of Matrix Metalloproteinases" Pancreatic secretion; Protein digestion and absorption; Influenza A; Neuroactive ligand-receptor interaction 1 High Q9D0F6 Replication factor C subunit 5 OS=Mus musculus OX=10090 GN=Rfc5 PE=1 SV=1 0 3.24 5 1 3 1 339 38.1 7.81 1 1 1 1 1 1 101630.3281 280942.375 414590.6563 514806.3125 1 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03215, Pf05496, Pf06068, Pf08542, Pf13086, Pf13173, Pf13177, Pf13191, Pf13401, Pf13479" 72151 ENSMUSG00000029363.14 Rfc5 5 Termination of translesion DNA synthesis; Polymerase switching on the C-strand of the telomere; Translesion synthesis by POLI; Activation of ATR in response to replication stress; Dual Incision in GG-NER; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Polymerase switching; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Translesion synthesis by REV1; G2/M DNA damage checkpoint DNA replication; Nucleotide excision repair; Mismatch repair 0 High Q8R1J9 Torsin-2A OS=Mus musculus OX=10090 GN=Tor2a PE=1 SV=1 0 12.162 16 3 3 3 321 35.9 6.83 3 3 186033.875 1532455.375 1 3 cell organization and biogenesis;metabolic process endoplasmic reticulum;organelle lumen nucleotide binding;protein binding Pf06309 30933 ENSMUSG00000009563.16 Tor2a 2 0 High O08547 Vesicle-trafficking protein SEC22b OS=Mus musculus OX=10090 GN=Sec22b PE=1 SV=3 0 9.73 20 3 3 3 215 24.7 8.51 3 3 444083.4688 1 Met-loss [N-Term] cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding "Pf00957, Pf13774" 20333 ENSMUSG00000027879.9 Sec22b 3 Cargo concentration in the ER; ER-Phagosome pathway; COPI-dependent Golgi-to-ER retrograde traffic; COPII (Coat Protein 2) Mediated Vesicle Transport Phagosome; SNARE interactions in vesicular transport; Legionellosis 0 Medium D6RGM2 O-phosphoseryl-tRNA(Sec) selenium transferase OS=Mus musculus OX=10090 GN=Sepsecs PE=1 SV=1 0.015 1.682 8 1 3 1 91 10.2 4.84 1 1 1 1 1 1 104211.3672 440398.4375 279334.1563 681327.5 1 1 1 1 metabolic process;regulation of biological process cytoplasm;nucleus catalytic activity;RNA binding ENSMUSG00000029173.12 5 0 High Q8BSF4 "Phosphatidylserine decarboxylase proenzyme, mitochondrial OS=Mus musculus OX=10090 GN=Pisd PE=2 SV=1" 0 7.456 7 3 3 3 406 45.9 9.57 3 3 180018.6406 85925.89844 3048735.125 1 1 3 metabolic process membrane;mitochondrion;nucleus catalytic activity Pf02666 320951 ENSMUSG00000023452.18 Pisd 5 Metabolic pathways; Glycerophospholipid metabolism 0 High Q9CWH6 Proteasome subunit alpha type-8 OS=Mus musculus OX=10090 GN=Psma8 PE=1 SV=1 0 2.869 4 1 3 1 250 27.8 8.69 1 1 1 1 1 1 1862199.375 6490181 7343773.563 21595420 1 1 1 1 metabolic process cytoplasm;cytosol;nucleus;proteasome catalytic activity "Pf00227, Pf10584" 73677 ENSMUSG00000036743.3 Psma8 18 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome 0 High Q5SX40 Myosin-1 OS=Mus musculus OX=10090 GN=Myh1 PE=1 SV=1 0 8.567 2 3 3 1 1942 223.2 5.76 3 3 238000.3438 1764245.375 1 2 metabolic process cytoplasm catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00063, Pf01576, Pf02736, Pf04111, Pf05622, Pf07888, Pf12128" 17879 ENSMUSG00000056328.14 Myh1 11 Tight junction 1 High P57716 Nicastrin OS=Mus musculus OX=10090 GN=Ncstn PE=1 SV=3 0 7.608 3 2 3 2 708 78.4 6.09 2 3 60904.50391 216167.5469 174652.8906 2872833.375 1 1 1 2 cell proliferation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;protein binding Pf05450 59287 ENSMUSG00000003458.12 Ncstn 1 Signaling by NOTCH3; Signaling by NOTCH; NRIF signals cell death from the nucleus; Neutrophil degranulation; Signalling by NGF; Nuclear signaling by ERBB4; Signaling by NOTCH4; Regulated proteolysis of p75NTR; EPH-ephrin mediated repulsion of cells Notch signaling pathway; Alzheimer's disease 0 High P48036 Annexin A5 OS=Mus musculus OX=10090 GN=Anxa5 PE=1 SV=1 0.007 1.989 3 1 3 1 319 35.7 4.96 1 1 1 1 1 1 228155.1563 321220.5313 178220.8594 533517.625 1 1 1 1 cell organization and biogenesis;coagulation;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus catalytic activity;metal ion binding;protein binding;transporter activity Pf00191 11747 ENSMUSG00000027712.13 Anxa5 3 Platelet degranulation 0 High Q8CD26 Solute carrier family 35 member E1 OS=Mus musculus OX=10090 GN=Slc35e1 PE=1 SV=2 0 10.019 11 3 3 3 409 44.3 9.88 3 3 1630756.813 2 transport Golgi;membrane "Pf03151, Pf08449" 270066 ENSMUSG00000019731.13 Slc35e1 8 0 Medium Q9WUK4 Replication factor C subunit 2 OS=Mus musculus OX=10090 GN=Rfc2 PE=1 SV=1 0.027 1.384 3 1 3 1 349 38.7 6.44 1 1 1 1 1 1 241976.1406 215952.3281 403384.0313 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf01078, Pf01443, Pf03215, Pf05496, Pf08542, Pf13086, Pf13173, Pf13177, Pf13191, Pf13207, Pf13238, Pf13245, Pf13401" 19718 ENSMUSG00000023104.9 Rfc2 5 Termination of translesion DNA synthesis; Polymerase switching on the C-strand of the telomere; Translesion synthesis by POLI; Activation of ATR in response to replication stress; Dual Incision in GG-NER; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Polymerase switching; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Translesion synthesis by REV1; G2/M DNA damage checkpoint DNA replication; Nucleotide excision repair; Mismatch repair 0 High Q3V009 Transmembrane emp24 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Tmed1 PE=1 SV=1 0 8.728 15 3 3 3 227 25.2 4.5 3 3 1682369.688 2 transport endoplasmic reticulum;Golgi;membrane Pf01105 17083 ENSMUSG00000032180.11 Tmed1 9 0 High Q9JII5 DAZ-associated protein 1 OS=Mus musculus OX=10090 GN=Dazap1 PE=1 SV=2 0 3.105 6 2 3 2 406 43.2 8.56 2 1 2 1 426534.1563 474378.2188 487316.8125 1 1 1 cell differentiation;cell proliferation;development;regulation of biological process cytoplasm;cytosol;nucleus RNA binding "Pf00076, Pf13893, Pf14259" 70248 ENSMUSG00000069565.12 Dazap1 10 mRNA surveillance pathway 0 High P06684 Complement C5 OS=Mus musculus OX=10090 GN=C5 PE=1 SV=2 0 4.119 1 1 3 1 1680 188.8 6.81 1 1 2 1 691692.5625 756164.5625 494772.3438 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf11974" 15139 ENSMUSG00000026874.10 Hc 2 Regulation of Complement cascade; Peptide ligand-binding receptors; G alpha (i) signalling events; Activation of C3 and C5; Terminal pathway of complement Herpes simplex infection; Staphylococcus aureus infection; Complement and coagulation cascades; Pertussis; Prion diseases; Systemic lupus erythematosus 0 High D3Z1S8 40S ribosomal protein S5 (Fragment) OS=Mus musculus OX=10090 GN=Rps5 PE=1 SV=1 0 8.256 20 3 3 3 189 21.1 9.52 1 2 1 2 925631 836346.5625 2163038.156 1 1 2 metabolic process ribosome RNA binding;structural molecule activity Pf00177 ENSMUSG00000012848.15 7 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" 0 High Q9CPP6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Mus musculus OX=10090 GN=Ndufa5 PE=1 SV=3 0 5.238 20 2 3 2 116 13.4 8.1 1 2 1 2 189424.375 324462.5391 1276275.75 1 2 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity Pf04716 68202 ENSMUSG00000023089.12 Ndufa5 6 Complex I biogenesis 0 High Q8K3W3 Protein CASC3 OS=Mus musculus OX=10090 GN=Casc3 PE=1 SV=3 0 6.569 9 3 3 3 698 75.7 6.44 3 3 366352.5469 1190279.5 1215516.094 583813.875 2 1 2 1 metabolic process;regulation of biological process;transport cytoplasm;membrane;nucleus protein binding;RNA binding Pf09405 192160 ENSMUSG00000078676.9 Casc3 11 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; RNA transport 0 High E9PVA8 eIF-2-alpha kinase activator GCN1 OS=Mus musculus OX=10090 GN=Gcn1 PE=1 SV=1 0 4.254 1 3 3 3 2671 292.8 7.36 3 3 802710.1875 2 cell communication;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane enzyme regulator activity;protein binding;RNA binding "Pf12074, Pf13646" 231659 ENSMUSG00000041638.18 Gcn1l1 5 0 High A2A5R2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Mus musculus OX=10090 GN=Arfgef2 PE=1 SV=1 0 6.606 2 3 3 3 1792 202.1 6.55 3 3 110497.2969 70229.70313 285621.3672 1516322.563 1 1 2 3 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane protein binding "Pf01369, Pf09324, Pf12783" 99371 ENSMUSG00000074582.10 Arfgef2 2 Endocytosis 0 High B1AR69 "Myosin, heavy polypeptide 13, skeletal muscle OS=Mus musculus OX=10090 GN=Myh13 PE=1 SV=1" 0 6.145 1 3 3 2 1938 223.4 5.57 3 3 700280.8828 3796194.125 3 3 cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity "Pf00038, Pf00063, Pf00261, Pf01576, Pf02463, Pf02736, Pf05483, Pf05557, Pf05622, Pf05701, Pf07888, Pf09726, Pf10174, Pf12128, Pf12718, Pf13166, Pf13514" 544791 ENSMUSG00000060180.12 Myh13 11 Striated Muscle Contraction Tight junction 1 High Q9CXE7 Transmembrane emp24 domain-containing protein 5 OS=Mus musculus OX=10090 GN=Tmed5 PE=1 SV=1 0 5.482 14 3 3 3 229 26.2 4.93 3 3 4004986.875 3 cell organization and biogenesis;transport endoplasmic reticulum;Golgi;membrane Pf01105 73130 ENSMUSG00000063406.11 Tmed5 5 WNT ligand biogenesis and trafficking 0 High Q791V5 Mitochondrial carrier homolog 2 OS=Mus musculus OX=10090 GN=Mtch2 PE=1 SV=1 0 7.738 12 3 3 3 303 33.5 8.25 3 3 172603.0625 648495.5625 732619.5313 1363336.75 2 2 2 2 cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus Pf00153 56428 ENSMUSG00000027282.17; ENSMUSG00000111714.1 Mtch2 2; CHR_MG191_PATCH 0 High A2AQ17 "Complex I intermediate-associated protein 30, mitochondrial OS=Mus musculus OX=10090 GN=Ndufaf1 PE=1 SV=1" 0 7.748 11 3 3 3 328 37.8 8.6 3 3 73664.125 775190.1563 1 2 cytosol;mitochondrion catalytic activity Pf08547 69702 ENSMUSG00000027305.9 Ndufaf1 2 Complex I biogenesis 0 High Q9JK42 "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial OS=Mus musculus OX=10090 GN=Pdk2 PE=1 SV=2" 0 10.601 7 3 3 2 407 46 6.61 3 3 276879.3438 3322158.188 1 2 cell communication;metabolic process;regulation of biological process;response to stimulus cytosol;mitochondrion;organelle lumen catalytic activity;nucleotide binding;protein binding "Pf02518, Pf10436" 18604 ENSMUSG00000038967.13 Pdk2 11 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid 0 High Q9DC23 DnaJ homolog subfamily C member 10 OS=Mus musculus OX=10090 GN=Dnajc10 PE=1 SV=2 0 4.193 3 3 3 3 793 90.5 6.96 3 3 179990.9844 1237968.023 970051.0703 2114456.25 2 3 3 3 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;enzyme regulator activity;protein binding "Pf00085, Pf00226, Pf13098, Pf13905" 66861 ENSMUSG00000027006.13 Dnajc10 2 Protein processing in endoplasmic reticulum 0 High Q9D0F4 NF-kappa-B-activating protein OS=Mus musculus OX=10090 GN=Nkap PE=2 SV=1 0 2.568 4 1 3 1 415 47.2 10.13 1 1 1 1 1 1 335461.5625 477941.7813 583485.1875 379604.25 1 1 1 1 cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus DNA binding;RNA binding Pf06047 67050 ENSMUSG00000016409.4 Nkap X 0 High Q04750 DNA topoisomerase 1 OS=Mus musculus OX=10090 GN=Top1 PE=1 SV=2 0 4.868 2 2 3 2 767 90.8 9.33 2 1 2 1 310224.875 794210.625 745710.5625 453850 2 2 2 2 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf01028, Pf02919, Pf14370" 21969 ENSMUSG00000070544.6 Top1 2 SUMOylation of DNA replication proteins 0 High Q3U0V1 Far upstream element-binding protein 2 OS=Mus musculus OX=10090 GN=Khsrp PE=1 SV=2 0 4.779 3 2 3 2 748 76.7 7.33 1 2 1 2 905659.4063 1286623.938 1012484.625 1183008.594 2 2 2 2 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane;nucleus DNA binding;RNA binding "Pf00013, Pf07650, Pf09005, Pf13014" 16549 ENSMUSG00000007670.9 Khsrp 17 KSRP (KHSRP) binds and destabilizes mRNA 0 High Q9ESP1 Stromal cell-derived factor 2-like protein 1 OS=Mus musculus OX=10090 GN=Sdf2l1 PE=1 SV=2 0 12.525 26 3 3 3 221 23.6 7.42 3 3 6830487.438 3 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;organelle lumen catalytic activity;protein binding Pf02815 64136 ENSMUSG00000022769.7 Sdf2l1 16 0 High Q9D6Y9 "1,4-alpha-glucan-branching enzyme OS=Mus musculus OX=10090 GN=Gbe1 PE=1 SV=1" 0 7.339 6 3 3 3 702 80.3 6.43 3 3 3217032.594 964907.4688 184849.1719 484619.125 3 2 1 1 metabolic process catalytic activity "Pf00128, Pf02806, Pf02922" 74185 ENSMUSG00000022707.16 Gbe1 16 Glycogen synthesis Metabolic pathways; Starch and sucrose metabolism 0 High Q62130 Tyrosine-protein phosphatase non-receptor type 14 OS=Mus musculus OX=10090 GN=Ptpn14 PE=1 SV=2 0 3.94 4 3 3 3 1189 135 8.34 3 3 1444152.375 4979528.875 3047400.375 4532408.75 1 2 2 3 metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus catalytic activity;protein binding "Pf00102, Pf00373, Pf00782, Pf09379, Pf09380" 19250 ENSMUSG00000026604.17 Ptpn14 1 0 High A0A0J9YUA8 Mediator of RNA polymerase II transcription subunit 13 OS=Mus musculus OX=10090 GN=Med13l PE=1 SV=1 0 4.629 1 3 3 2 2216 242.6 6.19 2 1 2 1 123503.2344 313073.5 236452.0938 1 1 1 metabolic process;regulation of biological process nucleus "Pf06333, Pf11597" 76199 ENSMUSG00000018076.12 Med13l 5 0 High Q8BGQ7 "Alanine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Aars1 PE=1 SV=1" 0 7.754 4 3 3 3 968 106.8 5.67 3 3 139434.9375 175978.1094 1280611.063 1 1 2 Acetyl [N-Term] metabolic process;regulation of biological process cytoplasm;cytosol;membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf01411, Pf02272, Pf07973" 234734 ENSMUSG00000031960.14 Aars 8 Aminoacyl-tRNA biosynthesis 0 Medium Q9QZZ4 Unconventional myosin-XV OS=Mus musculus OX=10090 GN=Myo15a PE=1 SV=2 0.034 1.19 0 1 3 1 3511 395.4 9.16 1 1 1 1 1 1 5780155.5 11404013 10896017 9021005 1 1 1 1 response to stimulus cytoplasm;cytoskeleton catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00373, Pf00784, Pf07653" 17910 ENSMUSG00000042678.16 Myo15 11 0 Low P09542 Myosin light chain 3 OS=Mus musculus OX=10090 GN=Myl3 PE=1 SV=4 0.052 0.994 5 1 3 1 204 22.4 5.1 1 3 150768.9063 263561.9219 1 1 regulation of biological process catalytic activity;metal ion binding;motor activity;protein binding Pf13499 17897 ENSMUSG00000059741.13 Myl3 9 Striated Muscle Contraction Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes 0 High A2BHN6 F-box only protein 3 OS=Mus musculus OX=10090 GN=Fbxo3 PE=1 SV=1 0 7.703 8 2 3 2 361 40.9 6.14 2 1 2 1 1823174.875 1422281.25 1582634.875 1 1 1 regulation of biological process cytosol;nucleus protein binding "Pf00646, Pf04379, Pf06881, Pf09346, Pf12937" 57443 ENSMUSG00000027180.12 Fbxo3 2 0 High A2A8U2 Transmembrane protein 201 OS=Mus musculus OX=10090 GN=Tmem201 PE=1 SV=1 0 7.419 5 3 3 3 664 72.5 9.2 3 3 181790.75 159838.1094 2074510.313 1 1 2 cell organization and biogenesis;cellular component movement membrane;nucleus protein binding "Pf09779, Pf10476" 230917 ENSMUSG00000044700.15 Tmem201 4 0 High A0A3Q4EBZ6 WD repeat-containing protein 46 (Fragment) OS=Mus musculus OX=10090 GN=Wdr46 PE=1 SV=1 0 3.037 5 1 2 1 329 36.4 9.41 1 2 5160590.625 7089064.375 3298509.625 1552510.563 1 1 1 1 0 High Q9Z1J3 "Cysteine desulfurase, mitochondrial OS=Mus musculus OX=10090 GN=Nfs1 PE=1 SV=3" 0 5.446 4 2 2 2 459 50.5 8.16 2 2 166936.9844 240432.9375 1872640.188 1 1 2 cell organization and biogenesis;metabolic process cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00266, Pf00282, Pf01212" 18041 ENSMUSG00000027618.17 Nfs1 2 Mitochondrial iron-sulfur cluster biogenesis; Molybdenum cofactor biosynthesis Thiamine metabolism; Metabolic pathways; Sulfur relay system 0 High A0A0G2JE46 HCLS1-associated protein X-1 OS=Mus musculus OX=10090 GN=Hax1 PE=1 SV=1 0 5.698 17 2 2 2 196 22.2 4.74 2 2 30639.45508 53434.11328 68036 1445697 1 1 1 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus protein binding 23897 ENSMUSG00000027944.13 Hax1 3 0 High P08122 Collagen alpha-2(IV) chain OS=Mus musculus OX=10090 GN=Col4a2 PE=1 SV=4 0 5.258 1 2 2 2 1707 167.2 8.48 1 1 1 1 227577.6563 2410152.75 1998936 830560.0625 1 2 2 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus extracellular structural molecule activity "Pf01391, Pf01413" 12827 ENSMUSG00000031503.13 Col4a2 8 Anchoring fibril formation; Laminin interactions; Crosslinking of collagen fibrils; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Non-integrin membrane-ECM interactions; Signaling by PDGF AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q9DBG7 Signal recognition particle receptor subunit alpha OS=Mus musculus OX=10090 GN=Srpra PE=1 SV=1 0 5.178 3 2 2 2 636 69.6 8.95 2 2 803025.5625 2 cell organization and biogenesis;transport endoplasmic reticulum;membrane catalytic activity;nucleotide binding;RNA binding "Pf00448, Pf02881, Pf04086" 67398 ENSMUSG00000032042.11 Srpr 9 Protein export 0 High Q8C7H1 "Methylmalonic aciduria type A homolog, mitochondrial OS=Mus musculus OX=10090 GN=Mmaa PE=1 SV=1" 0 2.333 6 2 2 2 415 45.9 9.32 2 2 824880.5 1 metabolic process mitochondrion catalytic activity;nucleotide binding "Pf02492, Pf03205, Pf03308, Pf12846" 109136 ENSMUSG00000037022.3 Mmaa 8 "Propionyl-CoA catabolism; Cobalamin (Cbl, vitamin B12) transport and metabolism" 0 High A0A1Y7VN19 Dehydrogenase/reductase SDR family member 7 (Fragment) OS=Mus musculus OX=10090 GN=Dhrs7 PE=1 SV=1 0 2.999 2 1 2 1 362 40.7 8.32 1 2 1320062.625 1 metabolic process catalytic activity "Pf00106, Pf08659, Pf13561" 0 High Q9EQH2 Endoplasmic reticulum aminopeptidase 1 OS=Mus musculus OX=10090 GN=Erap1 PE=1 SV=2 0 4.648 2 2 2 2 930 106.5 6.2 2 2 84260.99219 150751.7188 259848.2188 1224855.688 1 1 1 2 cell communication;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;extracellular;membrane;organelle lumen catalytic activity;metal ion binding;protein binding "Pf01433, Pf11838, Pf13485" 80898 ENSMUSG00000021583.6 Erap1 13 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" 0 High Q61810 Latent-transforming growth factor beta-binding protein 3 OS=Mus musculus OX=10090 GN=Ltbp3 PE=1 SV=4 0 3.516 3 2 2 2 1253 134.3 6.18 2 2 714541.5625 1 0 High Q2TBA9 Sox5 protein OS=Mus musculus OX=10090 GN=Sox5 PE=1 SV=1 0 2.429 2 1 2 1 715 79.2 6.29 1 1 1 1 cell differentiation;cell division;metabolic process;regulation of biological process;response to stimulus nucleus DNA binding;protein binding "Pf00505, Pf09011" 20678 ENSMUSG00000041540.16 Sox5 6 0 Medium Q9ERA6 Tuftelin-interacting protein 11 OS=Mus musculus OX=10090 GN=Tfip11 PE=1 SV=1 0.018 1.584 1 1 2 1 838 96.2 5.9 1 1 1 1 164519.375 262969.75 300507.6875 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus;spliceosomal complex DNA binding;protein binding "Pf01585, Pf07842, Pf12457, Pf12656" 54723 ENSMUSG00000029345.13 Tfip11 5 mRNA Splicing - Major Pathway 0 High D6RG69 Coiled-coil domain-containing protein 167 OS=Mus musculus OX=10090 GN=Ccdc167 PE=1 SV=1 0 6.359 50 2 2 2 54 6.1 8.16 2 2 555845.75 410498.1563 561083.4375 2150466.625 1 1 1 2 Pf15188 ENSMUSG00000024018.17 17 0 High Q64516 Glycerol kinase OS=Mus musculus OX=10090 GN=Gk PE=1 SV=2 0 3.84 5 2 2 2 559 61.2 5.87 2 2 1002836.781 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding "Pf00370, Pf02782" 14933 ENSMUSG00000025059.16 Gyk; Gk X Triglyceride biosynthesis PPAR signaling pathway; Metabolic pathways; Glycerolipid metabolism 0 High B1ASP2 Tyrosine-protein kinase OS=Mus musculus OX=10090 GN=Jak1 PE=1 SV=1 0 6.804 2 2 2 2 1153 133.3 7.53 2 2 452071.7813 1 cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714" 16451 ENSMUSG00000028530.14 Jak1 4 Interleukin-7 signaling; Interleukin-35 Signalling; Regulation of IFNG signaling; ISG15 antiviral mechanism; Interleukin-15 signaling; Interleukin receptor SHC signaling; G beta:gamma signalling through PI3Kgamma; Regulation of IFNA signaling; Interleukin-10 signaling; Interleukin-20 family signaling; RAF/MAP kinase cascade; IL-6-type cytokine receptor ligand interactions; MAPK1 (ERK2) activation; MAPK3 (ERK1) activation; GPVI-mediated activation cascade; Interleukin-4 and 13 signaling; Interleukin-9 signaling Herpes simplex infection; NOD-like receptor signaling pathway; Jak-STAT signaling pathway; Toxoplasmosis; Epstein-Barr virus infection; Signaling pathways regulating pluripotency of stem cells; Tuberculosis; Hepatitis B; HTLV-I infection; Osteoclast differentiation; Pathways in cancer; Influenza A; Hepatitis C; Pancreatic cancer; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance; Leishmaniasis; Th1 and Th2 cell differentiation; Viral carcinogenesis; Measles 0 High Q9CQE3 "28S ribosomal protein S17, mitochondrial OS=Mus musculus OX=10090 GN=Mrps17 PE=1 SV=1" 0 3.108 8 1 2 1 120 13.4 9.89 1 1 1 1 427048.25 659817.5 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00366 66258 ENSMUSG00000034211.14 Mrps17 5 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High Q05DV1 NADPH--cytochrome P450 reductase OS=Mus musculus OX=10090 GN=Por PE=1 SV=1 0 5.868 3 2 2 2 649 72.9 5.58 2 2 199629.5156 948864.7188 1 2 metabolic process;regulation of biological process endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00175, Pf00258, Pf00667" 18984 ENSMUSG00000005514.14 Por 5 0 High E9QN31 Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Mus musculus OX=10090 GN=Nop2 PE=1 SV=1 0 3.773 2 1 2 1 794 86.9 9.19 1 1 1 1 88722.78906 406527.3438 425458.5 355832.5313 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;RNA binding "Pf01189, Pf12847" 110109 ENSMUSG00000038279.10 Nop2 6 0 High Q3TJZ6 Protein FAM98A OS=Mus musculus OX=10090 GN=Fam98a PE=1 SV=1 0.001 2.184 9 1 2 1 515 55 8.95 1 1 1 1 metabolic process;regulation of biological process catalytic activity;protein binding;RNA binding Pf10239 72722 ENSMUSG00000002017.9 Fam98a 17 0 High J3QMG3 Voltage-dependent anion-selective channel protein 3 OS=Mus musculus OX=10090 GN=Vdac3 PE=1 SV=1 0 2.264 5 1 2 1 284 30.8 8.79 1 1 1 1 313429.8438 313798.3438 478723.2188 1 1 1 regulation of biological process;transport membrane;mitochondrion transporter activity Pf01459 ENSMUSG00000008892.12 8 0 High Q3TBW2 "39S ribosomal protein L10, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl10 PE=1 SV=2" 0 3.565 10 2 2 2 262 29.4 9.69 2 2 115556.4922 179572.2344 279714.25 1 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity 107732 ENSMUSG00000001445.10 Mrpl10 11 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High A0A3Q4EI12 Ras-related protein Rab-18 OS=Mus musculus OX=10090 GN=Rab18 PE=1 SV=1 0 5.101 12 2 2 2 212 23.8 5.25 2 2 424466.25 451023.2188 1590463.75 1 1 2 0 Medium A0A140T8N8 Immunoglobulin kappa variable 9-123 (Fragment) OS=Mus musculus OX=10090 GN=Igkv9-123 PE=4 SV=2 0.021 1.548 14 1 2 1 117 12.8 6.54 1 1 1 1 41506.26172 451942.6563 452933.125 543500.375 1 1 1 1 "Pf00047, Pf07679, Pf07686" 628144 ENSMUSG00000076512.2 Igkv9-123 6 0 High Q9CZD3 Glycine--tRNA ligase OS=Mus musculus OX=10090 GN=Gars1 PE=1 SV=1 0 3.441 2 2 2 2 729 81.8 6.65 2 2 108354.0938 151253.125 1485853.5 1 1 2 metabolic process cytoplasm;cytosol;extracellular;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00458, Pf00587, Pf03129" 353172 ENSMUSG00000029777.10 Gars 6 Aminoacyl-tRNA biosynthesis 0 High Q8VBZ3 Cleft lip and palate transmembrane protein 1 homolog OS=Mus musculus OX=10090 GN=Clptm1 PE=1 SV=1 0 5.518 4 1 2 1 664 75.2 6.3 1 2 1493414.125 1 cell differentiation;development;regulation of biological process membrane Pf05602 56457 ENSMUSG00000002981.10 Clptm1 7 0 High A2A9V7 Mitochondrial thiamine pyrophosphate carrier (Fragment) OS=Mus musculus OX=10090 GN=Slc25a19 PE=1 SV=8 0 6.508 10 2 2 2 225 25.3 9.14 2 2 116369.0313 131741.1094 1454036.875 1 1 1 transport membrane;mitochondrion Pf00153 ENSMUSG00000020744.13 11 0 High P31786 Acyl-CoA-binding protein OS=Mus musculus OX=10090 GN=Dbi PE=1 SV=2 0 6.429 38 2 2 2 87 10 8.82 2 2 3598862.281 2261386.953 2051191.328 4416390.375 2 2 2 2 Met-loss+Acetyl [N-Term] cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;Golgi;membrane;mitochondrion;nucleus protein binding Pf00887 13167 ENSMUSG00000026385.16 Dbi 1 Mitochondrial Fatty Acid Beta-Oxidation PPAR signaling pathway 0 High Q9R1T2 SUMO-activating enzyme subunit 1 OS=Mus musculus OX=10090 GN=Sae1 PE=1 SV=1 0 2.8 5 2 2 2 350 38.6 5.36 2 2 34944.23047 245572.3906 246320.1094 974051.0625 1 1 1 2 metabolic process cytoplasm;nucleus catalytic activity;protein binding Pf00899 56459 ENSMUSG00000052833.9 Sae1 7 "SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is conjugated to E1 (UBA2:SAE1)" Ubiquitin mediated proteolysis 0 High Q7TMG7 Atrial natriuretic peptide receptor 3 OS=Mus musculus OX=10090 GN=Npr3 PE=1 SV=1 0 4.663 4 2 2 2 535 59.7 7.09 2 2 775742.9375 1 cell proliferation;regulation of biological process;response to stimulus;transport membrane protein binding;receptor activity;signal transducer activity Pf01094 18162 Npr3 15 0 High P62274 40S ribosomal protein S29 OS=Mus musculus OX=10090 GN=Rps29 PE=1 SV=2 0 3.963 34 2 2 2 56 6.7 10.13 2 2 934202.9063 2182807.25 1141900.625 734883.6875 2 2 2 1 Met-loss [N-Term] metabolic process;regulation of biological process ribosome metal ion binding;structural molecule activity Pf00253 20090 ENSMUSG00000034892.8 Rps29 12 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High Q9DCC4 Pyrroline-5-carboxylate reductase 3 OS=Mus musculus OX=10090 GN=Pycr3 PE=1 SV=2 0 9.798 12 2 2 2 274 28.7 7.27 2 2 156800.0938 1070070.656 1 2 metabolic process cytoplasm;cytosol catalytic activity;protein binding "Pf03807, Pf14748" 66194 ENSMUSG00000022571.8 Pycrl 15 Amino acid synthesis and interconversion (transamination) Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids 0 High Q9CQ49 Nuclear cap-binding protein subunit 2 OS=Mus musculus OX=10090 GN=Ncbp2 PE=1 SV=1 0.001 2.192 5 1 2 1 156 18 7.81 1 1 1 1 120470.3516 315889.625 241543.5781 209324.6094 1 1 1 1 metabolic process;regulation of biological process;transport cytoplasm;nucleus RNA binding "Pf00076, Pf13893, Pf14259" 68092 ENSMUSG00000022774.12 Ncbp2 16 mRNA Capping; RNA Polymerase II Pre-transcription Events; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; mRNA Splicing - Major Pathway; snRNP Assembly; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; mRNA 3'-end processing; Processing of Intronless Pre-mRNAs; RNA polymerase II transcribes snRNA genes; Formation of the Early Elongation Complex; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; SLBP independent Processing of Histone Pre-mRNAs mRNA surveillance pathway; Spliceosome; RNA transport 0 High A0A1B0GX27 Branched-chain-amino-acid aminotransferase OS=Mus musculus OX=10090 GN=Bcat2 PE=1 SV=1 0 4.371 6 2 2 2 388 43.5 8.43 2 2 311063.4063 1213161.531 1 2 metabolic process catalytic activity Pf01063 ENSMUSG00000030826.19 7 0 High Q6GQT1 Alpha-2-macroglobulin-P OS=Mus musculus OX=10090 GN=A2m PE=2 SV=2 0 3.088 1 1 2 1 1474 164.2 6.61 1 1 1 1 165064 136187.4531 405559.6875 1 1 1 cell differentiation;regulation of biological process extracellular enzyme regulator activity;protein binding "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249" 232345 ENSMUSG00000030111.9 A2m 6 Intrinsic Pathway of Fibrin Clot Formation; Rho GTPase cycle; Degradation of the extracellular matrix; HDL assembly; Platelet degranulation Complement and coagulation cascades 0 High Q9EQ61 Pescadillo homolog OS=Mus musculus OX=10090 GN=Pes1 PE=1 SV=1 0.008 1.954 2 1 2 1 584 67.8 6.84 1 1 1 1 251541.7969 285444.5625 363912.6563 1 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process chromosome;cytosol;membrane;nucleus protein binding;RNA binding "Pf00533, Pf06732" 64934 ENSMUSG00000020430.12 Pes1 11 Major pathway of rRNA processing in the nucleolus and cytosol 0 High E9PXU2 Disintegrin and metalloproteinase domain-containing protein 17 OS=Mus musculus OX=10090 GN=Adam17 PE=1 SV=1 0 5.664 3 2 2 2 846 95.2 5.88 2 2 170541.9063 139921.7344 3010770.25 1 1 2 cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;cytosol;extracellular;membrane catalytic activity;metal ion binding;protein binding "Pf00200, Pf01421, Pf01562, Pf13574, Pf13582, Pf13583, Pf13688" 11491 ENSMUSG00000052593.15 Adam17 12 0 High P62334 26S proteasome regulatory subunit 10B OS=Mus musculus OX=10090 GN=Psmc6 PE=1 SV=1 0 7.525 6 2 2 2 389 44.1 7.49 2 2 636245.5625 887102.5 872265.7969 1638979.75 1 1 2 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401" 67089 ENSMUSG00000021832.7 Psmc6 14 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High Q9DCJ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Mus musculus OX=10090 GN=Ndufa8 PE=1 SV=3 0 6.128 10 1 2 1 172 20 8.46 1 2 1896867.563 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion protein binding Pf06747 68375 ENSMUSG00000026895.7 Ndufa8 2 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High A0A140LJK5 Glutaminyl-tRNA synthetase (Fragment) OS=Mus musculus OX=10090 GN=Qars PE=1 SV=2 0 5.475 15 2 2 2 182 20.3 8.13 2 2 48485.15234 43993.38672 1080350.234 1 1 2 Met-loss+Acetyl [N-Term] metabolic process cytoplasm catalytic activity;nucleotide binding "Pf04557, Pf04558" ENSMUSG00000032604.16 9 0 High Q8CGV5 Matrix metallopeptidase 28 (Epilysin) OS=Mus musculus OX=10090 GN=Mmp28 PE=1 SV=1 0 4.135 4 2 2 2 510 57.3 9.47 2 2 metabolic process;regulation of biological process cytoplasm catalytic activity;metal ion binding "Pf00045, Pf00413, Pf01471, Pf13574, Pf13688" 118453 ENSMUSG00000020682.17 Mmp28 11 0 High F7B6K4 4'-phosphopantetheine phosphatase (Fragment) OS=Mus musculus OX=10090 GN=Pank4 PE=1 SV=1 0 7.3 7 2 2 2 473 53.2 6.4 2 2 1145814.75 2 metabolic process catalytic activity;nucleotide binding "Pf01937, Pf03630" ENSMUSG00000029056.13 4 0 High Q9ESW8 Pyroglutamyl-peptidase 1 OS=Mus musculus OX=10090 GN=Pgpep1 PE=1 SV=1 0 7.683 13 2 2 2 209 22.9 5.39 2 2 175289.2656 136688.0938 983493.25 1 1 1 metabolic process cytoplasm;cytosol catalytic activity Pf01470 66522 ENSMUSG00000056204.8 Pgpep1 8 0 High Q9ERS2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Mus musculus OX=10090 GN=Ndufa13 PE=1 SV=3 0 3.363 6 1 2 1 144 16.8 9.48 1 2 1360895.375 1 cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding Pf06212 67184 ENSMUSG00000036199.9 Ndufa13 8 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q91XX6 Protocadherin gamma B4 OS=Mus musculus OX=10090 GN=Pcdhgb4 PE=1 SV=1 0 5.864 2 1 2 1 912 99.2 5.01 1 1 1 1 218933.7578 563132.6563 503658.0781 883955.8125 2 2 2 1 cell communication membrane metal ion binding;protein binding "Pf00028, Pf08266" 93701 ENSMUSG00000103585.1 Pcdhgb4 18 0 High Q9JIK9 "28S ribosomal protein S34, mitochondrial OS=Mus musculus OX=10090 GN=Mrps34 PE=1 SV=1" 0 4.347 10 2 2 2 218 25.8 10.43 1 1 1 1 202700.0156 225789.4531 452673.2813 1 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome structural molecule activity 79044 ENSMUSG00000038880.13 Mrps34 17 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q3TEA8 Heterochromatin protein 1-binding protein 3 OS=Mus musculus OX=10090 GN=Hp1bp3 PE=1 SV=1 0 3.864 4 2 2 2 554 60.8 9.7 2 2 409355.3125 1263342.594 977741.625 1239194.156 2 2 2 2 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf00538 15441 ENSMUSG00000028759.13 Hp1bp3 4 0 High Q01768 Nucleoside diphosphate kinase B OS=Mus musculus OX=10090 GN=Nme2 PE=1 SV=1 0 2.722 16 2 2 2 152 17.4 7.5 2 2 93649.36719 115853.2344 107123.2109 1075326.313 1 1 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf00334 18103 ENSMUSG00000020857.11 Nme2 11 Interconversion of nucleotide di- and triphosphates; Neutrophil degranulation Metabolic pathways; Purine metabolism; Pyrimidine metabolism 0 Medium P58064 "28S ribosomal protein S6, mitochondrial OS=Mus musculus OX=10090 GN=Mrps6 PE=1 SV=3" 0.014 1.707 9 1 2 1 125 14.3 9.5 1 1 1 1 176029.3906 872690.4375 868728.7188 1172248.156 1 1 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf01250 121022 ENSMUSG00000039680.9 Mrps6 16 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Medium H3BLA9 Sentrin-specific protease 6 (Fragment) OS=Mus musculus OX=10090 GN=Senp6 PE=1 SV=1 0.014 1.718 3 1 2 1 204 23.5 5.85 1 1 1 1 304608.6875 822518.625 705105.4375 1544078.5 1 1 1 1 metabolic process catalytic activity Pf02902 ENSMUSG00000034252.14 9 0 High Q3THE2 Myosin regulatory light chain 12B OS=Mus musculus OX=10090 GN=Myl12b PE=1 SV=2 0 4.33 12 2 2 2 172 19.8 4.84 1 1 1 1 152161.9375 308258.2813 607057.4375 342723.875 1 1 1 1 regulation of biological process metal ion binding;protein binding "Pf00036, Pf13202, Pf13405, Pf13833" 67938 ENSMUSG00000034868.8 Myl12b 17 RHO GTPases activate PAKs; Smooth Muscle Contraction Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Focal adhesion; Platelet activation; Tight junction 0 High P13541 Myosin-3 OS=Mus musculus OX=10090 GN=Myh3 PE=2 SV=2 0 5.878 1 2 2 1 1940 223.7 5.81 2 2 362753.5938 2068887.125 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00063, Pf00261, Pf01496, Pf01576, Pf02463, Pf02736, Pf04012, Pf04111, Pf05557, Pf05622, Pf05667, Pf05701, Pf06160, Pf07888, Pf08317, Pf09726, Pf10174, Pf12128, Pf12718, Pf13514, Pf15070" 17883 ENSMUSG00000020908.14 Myh3 11 Tight junction 0 High Q8CFH6 Serine/threonine-protein kinase SIK2 OS=Mus musculus OX=10090 GN=Sik2 PE=1 SV=1 0 5.184 3 2 2 2 931 104.1 6.13 2 2 1254336.438 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00069, Pf07714, Pf14531" 235344 Sik2 9 Glucagon signaling pathway 0 High A0A1B0GR60 Ferritin OS=Mus musculus OX=10090 GN=Ftl1 PE=1 SV=1 0 2.829 10 1 2 1 160 18 6.28 1 1 1 1 1059048.375 705192.6875 1 1 cellular homeostasis;transport metal ion binding Pf00210 ENSMUSG00000050708.16 7 Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport 0 High Q80X19 Collagen alpha-1(XIV) chain OS=Mus musculus OX=10090 GN=Col14a1 PE=1 SV=2 0.001 2.171 1 1 2 1 1797 192.9 5.1 1 1 1 1 798178 2535749.25 1895931 1146197.875 1 1 1 1 cell organization and biogenesis;regulation of biological process extracellular protein binding;RNA binding "Pf00041, Pf00092, Pf01391, Pf13519" 12818 ENSMUSG00000022371.15 Col14a1 15 Collagen chain trimerization; Assembly of collagen fibrils and other multimeric structures 0 Medium A2BFF8 Cytoplasmic dynein 1 intermediate chain 2 OS=Mus musculus OX=10090 GN=Dync1i2 PE=1 SV=1 0.047 1.056 5 1 2 1 611 68.2 5.29 1 2 cellular component movement;regulation of biological process;transport cytoplasm;cytoskeleton;mitochondrion catalytic activity;motor activity;protein binding "Pf00400, Pf11540" 13427 ENSMUSG00000027012.15 Dync1i2 2 0 Medium Q8R4E6 Purine-rich element-binding protein gamma OS=Mus musculus OX=10090 GN=Purg PE=1 SV=1 0.023 1.444 2 1 2 1 350 39.9 9.51 1 1 1 1 121516.5234 347249.2188 219931.9063 399873.5 1 1 1 1 nucleus DNA binding;RNA binding Pf04845 75029 ENSMUSG00000049184.6 Purg 8 0 High Q8BU30 "Isoleucine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Iars1 PE=1 SV=2" 0 3.799 2 2 2 2 1262 144.2 6.55 2 2 103489.8594 160386.2188 137696.125 1427803.688 1 1 1 2 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00133, Pf01406, Pf08264, Pf09334" 105148 ENSMUSG00000037851.13 Iars 13 Aminoacyl-tRNA biosynthesis 0 Low P06328 Ig heavy chain V region 1-72 OS=Mus musculus OX=10090 GN=Ighv1-72 PE=1 SV=2 0.053 0.987 6 1 2 1 117 12.9 9.29 1 1 1 1 339919.4063 3581706 3075984 4059121 1 1 1 1 0 High Q01730 Ras suppressor protein 1 OS=Mus musculus OX=10090 GN=Rsu1 PE=1 SV=3 0 4.185 6 2 2 2 277 31.5 8.88 2 2 204097.7031 580622.2109 73810.49219 1286211.313 1 2 1 2 regulation of biological process;response to stimulus protein binding "Pf12799, Pf13855" 20163 Rsu1 2 0 High Q3UPL0 Protein transport protein Sec31A OS=Mus musculus OX=10090 GN=Sec31a PE=1 SV=2 0 5.94 2 2 2 2 1230 133.5 6.76 2 2 173002.4688 672081.1875 1 1 cell organization and biogenesis;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane protein binding "Pf03154, Pf12931" 69162 ENSMUSG00000035325.16 Sec31a 5 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation" Protein processing in endoplasmic reticulum 0 High Q80UU9 Membrane-associated progesterone receptor component 2 OS=Mus musculus OX=10090 GN=Pgrmc2 PE=1 SV=2 0 4.657 15 2 2 2 217 23.3 5.15 2 2 33175.61719 76262.9375 108972.7188 734302.125 1 1 1 2 membrane protein binding Pf00173 70804 ENSMUSG00000049940.7 Pgrmc2 3 0 High E9QAF4 "Pleckstrin homology-like domain, family B, member 3 OS=Mus musculus OX=10090 GN=Phldb3 PE=1 SV=1" 0 2.49 1 1 2 1 648 72.7 6.24 1 1 1 1 1016535.5 1418677.125 1896003.625 1237370 1 1 1 1 protein binding "Pf00169, Pf12128, Pf14593" 232970 ENSMUSG00000074277.4 Phldb3 7 0 Medium P62892 60S ribosomal protein L39 OS=Mus musculus OX=10090 GN=Rpl39 PE=1 SV=2 0.021 1.512 20 1 2 1 51 6.4 12.56 1 1 1 1 937980 2303726 1839067.75 2003309.875 1 1 1 1 defense response;metabolic process;response to stimulus ribosome protein binding;RNA binding;structural molecule activity Pf00832 67248 ENSMUSG00000079641.3 Rpl39 X Ribosome 0 High Q8BK06 F-box only protein 9 OS=Mus musculus OX=10090 GN=Fbxo9 PE=1 SV=1 0 2.457 4 2 2 2 437 50.7 6.84 1 1 1 1 485023.3125 332753.75 1019516 1 1 2 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;protein binding "Pf00646, Pf04212, Pf12937" 71538 ENSMUSG00000001366.14 Fbxo9 9 Neddylation; Antigen processing: Ubiquitination & Proteasome degradation 0 Medium Q8R2U0 Nucleoporin SEH1 OS=Mus musculus OX=10090 GN=Seh1l PE=2 SV=1 0.021 1.52 3 1 2 1 360 39.7 8.05 1 1 1 1 141528.3594 235593.0625 233325.9375 522246.6875 1 1 1 1 cell communication;cell division;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport chromosome;membrane;nucleus;vacuole protein binding Pf00400 72124 ENSMUSG00000079614.3 Seh1l 18 Transcriptional regulation by small RNAs; SUMOylation of RNA binding proteins; snRNP Assembly; SUMOylation of chromatin organization proteins; Resolution of Sister Chromatid Cohesion; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Separation of Sister Chromatids; RHO GTPases Activate Formins; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins; SUMOylation of DNA replication proteins mTOR signaling pathway; RNA transport 0 High A0A1W2P7B7 T-complex protein 1 subunit beta (Fragment) OS=Mus musculus OX=10090 GN=Cct2 PE=1 SV=1 0 2.397 6 1 2 1 217 22.9 6.06 1 1 1 1 135401.2188 1 Met-loss+Acetyl [N-Term] metabolic process nucleotide binding;protein binding Pf00118 ENSMUSG00000034024.8 10 0 High Q8BWM0 Prostaglandin E synthase 2 OS=Mus musculus OX=10090 GN=Ptges2 PE=1 SV=3 0 5.739 4 2 2 2 384 43.3 9 2 2 1290227.063 2 cellular homeostasis;metabolic process;regulation of biological process;transport cytoplasm;cytosol;Golgi;membrane;mitochondrion;nucleus catalytic activity;DNA binding;protein binding "Pf00462, Pf13409, Pf13417, Pf14497" 96979 ENSMUSG00000026820.5 Ptges2 2 Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Metabolic pathways; Arachidonic acid metabolism 0 High Q3TVI8 Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Mus musculus OX=10090 GN=Pbxip1 PE=1 SV=2 0 6.268 4 2 2 2 727 81.1 5.36 2 2 53733.54297 204238.0469 1 1 cell differentiation;regulation of biological process cytoplasm;cytoskeleton;nucleus 229534 ENSMUSG00000042613.9 Pbxip1 3 0 High A0A5F8MPX4 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Mus musculus OX=10090 GN=Ptpmt1 PE=1 SV=1 0 4.017 10 2 2 2 260 28.4 9.86 2 2 579220.5 1 0 High Q6P5G6 UBX domain-containing protein 7 OS=Mus musculus OX=10090 GN=Ubxn7 PE=1 SV=2 0 2.237 7 1 2 1 467 52.1 5.03 1 2 1922330.5 780280 765631 1513402.5 1 1 1 1 nucleus protein binding "Pf00789, Pf13899, Pf14555" 224111 Ubxn7 16 0 High Q6P2B1 Transportin-3 OS=Mus musculus OX=10090 GN=Tnpo3 PE=1 SV=1 0 2.388 3 1 2 1 923 104.1 5.57 1 1 1 1 2934687.25 3050987.75 3256569.25 2978221.5 1 1 1 1 Acetyl [N-Term] transport cytoplasm;membrane;nucleus protein binding;transporter activity Pf08389 320938 ENSMUSG00000012535.14 Tnpo3 6 0 High P13439 Uridine 5'-monophosphate synthase OS=Mus musculus OX=10090 GN=Umps PE=1 SV=3 0 5.335 6 2 2 2 481 52.3 6.61 2 2 539597.125 1 metabolic process;response to stimulus;transport cytoplasm;nucleus catalytic activity;protein binding "Pf00156, Pf00215" 22247 ENSMUSG00000022814.6 Umps 16 Pyrimidine biosynthesis Metabolic pathways; Pyrimidine metabolism; Drug metabolism - other enzymes 0 High Q3USZ8 Divergent protein kinase domain 2A OS=Mus musculus OX=10090 GN=Dipk2a PE=1 SV=2 0 6.221 5 2 2 2 430 49.4 8.63 2 2 63282.47656 1390751.125 1 2 cell proliferation;regulation of biological process extracellular;Golgi;membrane Pf12260 68861 ENSMUSG00000045414.7 1190002N15Rik 9 0 High P97350 Plakophilin-1 OS=Mus musculus OX=10090 GN=Pkp1 PE=1 SV=1 0 4.603 3 1 2 1 728 80.8 8.91 1 1 1 1 313061.5 537643.9375 411175.5625 301452.875 1 1 1 1 cell organization and biogenesis;regulation of biological process membrane;nucleus protein binding Pf00514 18772 ENSMUSG00000026413.12 Pkp1 1 Formation of the cornified envelope; Neutrophil degranulation 0 High Q8BFZ9 Erlin-2 OS=Mus musculus OX=10090 GN=Erlin2 PE=1 SV=1 0 4.756 6 2 2 2 340 37.8 5.5 2 2 940867.8125 1 metabolic process;regulation of biological process;response to stimulus cytosol;endoplasmic reticulum;membrane protein binding Pf01145 244373 ENSMUSG00000031483.8 Erlin2 8 ABC-family proteins mediated transport 0 High Q99104 Unconventional myosin-Va OS=Mus musculus OX=10090 GN=Myo5a PE=1 SV=2 0 3.175 1 1 2 1 1853 215.4 8.63 1 1 1 1 512083.2188 337629.5625 518785.0938 1 1 1 cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;vacuole catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;RNA binding "Pf00063, Pf00261, Pf00612, Pf00769, Pf01442, Pf01843, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf06548, Pf06705, Pf07028, Pf07888, Pf07926, Pf08317, Pf09311, Pf09726, Pf10174, Pf12128" 17918 ENSMUSG00000034593.16 Myo5a 9 0 High Q8BK64 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus OX=10090 GN=Ahsa1 PE=1 SV=2 0 2.711 4 2 2 2 338 38.1 5.53 2 2 58868.94141 366864.7891 441260.5938 1643788.563 1 2 2 2 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum enzyme regulator activity;protein binding "Pf08327, Pf09229" 217737 ENSMUSG00000021037.6 Ahsa1 12 0 High Q99KP6 Pre-mRNA-processing factor 19 OS=Mus musculus OX=10090 GN=Prpf19 PE=1 SV=1 0 2.615 2 1 2 1 504 55.2 6.61 1 1 1 1 300675.4063 962601.75 796202.9375 1401524.125 1 1 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex catalytic activity;metal ion binding;protein binding "Pf00400, Pf04564, Pf08606, Pf11789" 28000 ENSMUSG00000024735.13 Prpf19 19 mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex Ubiquitin mediated proteolysis; Spliceosome 0 Medium P83870 PHD finger-like domain-containing protein 5A OS=Mus musculus OX=10090 GN=Phf5a PE=1 SV=1 0.021 1.538 6 1 2 1 110 12.4 8.41 1 1 1 1 214835.6094 389084.4063 350086.8438 264901.5938 1 1 1 1 metabolic process;regulation of biological process nucleus;spliceosomal complex DNA binding;metal ion binding;protein binding;RNA binding Pf03660 68479 ENSMUSG00000061360.7 Phf5a 15 mRNA Splicing - Major Pathway Spliceosome 0 High Q9CXU1 Mediator of RNA polymerase II transcription subunit 31 OS=Mus musculus OX=10090 GN=Med31 PE=1 SV=2 0 4.759 17 2 2 2 131 15.8 8.54 2 2 548984.6406 837359.3125 575742.3125 1629704.594 2 1 1 2 metabolic process;regulation of biological process nucleus catalytic activity;protein binding Pf05669 67279 ENSMUSG00000020801.8 Med31 11 Generic Transcription Pathway; Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High Q8C1A9 Protein ABHD18 OS=Mus musculus OX=10090 GN=Abhd18 PE=2 SV=1 0 3.732 3 2 2 2 464 53.1 8.79 2 2 810681.1875 2 extracellular Pf09752 269423 ENSMUSG00000037818.16 3110057O12Rik; Abhd18 3 0 High Q8K3J1 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs8 PE=1 SV=1" 0 4.774 8 2 2 2 212 24 6.21 2 2 55180.13281 253126.9531 122633.0781 988701.625 1 1 1 1 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding "Pf00037, Pf12797, Pf12837, Pf12838, Pf13183, Pf13187, Pf13237, Pf13459, Pf13484, Pf13534, Pf14697" 225887 ENSMUSG00000059734.6 Ndufs8 19 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q9Z2A7 Diacylglycerol O-acyltransferase 1 OS=Mus musculus OX=10090 GN=Dgat1 PE=1 SV=1 0 6.32 6 2 2 2 498 56.8 9.39 2 2 179531.7969 321561.8438 2696963.906 1 1 2 cell organization and biogenesis;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane catalytic activity "Pf03062, Pf13813" 13350 ENSMUSG00000022555.11 Dgat1 15 Triglyceride biosynthesis; Neutrophil degranulation; Acyl chain remodeling of DAG and TAG Retinol metabolism; Fat digestion and absorption; Metabolic pathways; Glycerolipid metabolism 0 High B8JJX7 Survival motor neuron protein (Fragment) OS=Mus musculus OX=10090 GN=Smn1 PE=1 SV=8 0.008 1.966 8 1 2 1 161 17.5 5.27 1 1 1 1 413239.4688 785845.125 598200.875 805975.8125 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;nucleus RNA binding "Pf00567, Pf06003" ENSMUSG00000021645.16 13 0 High Q924L1 LETM1 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Letmd1 PE=1 SV=1 0 8.296 7 2 2 2 360 41.7 10.54 2 2 584648.4375 636595.5 596783.8125 1897620.375 1 1 1 2 cellular homeostasis membrane;mitochondrion Pf07766 68614 ENSMUSG00000037353.8 Letmd1 15 0 High G3XA18 N-acylethanolamine-hydrolyzing acid amidase OS=Mus musculus OX=10090 GN=Naaa PE=1 SV=1 0 3.693 4 2 2 2 360 39.8 6.44 2 2 184824.375 141777.0156 1431075.875 1 1 2 metabolic process cytoplasm;vacuole catalytic activity;protein binding "Pf02275, Pf15508" 67111 ENSMUSG00000029413.14 Naaa 5 0 Medium D3Z132 THO complex subunit 6 homolog OS=Mus musculus OX=10090 GN=Thoc6 PE=1 SV=1 0.016 1.646 4 1 2 1 337 37.1 7.65 1 1 1 1 166589.6563 238261.2813 215821.2813 208246.7656 1 1 1 1 protein binding Pf00400 ENSMUSG00000041319.13 17 0 High Q4V9W2 Protein SREK1IP1 OS=Mus musculus OX=10090 GN=Srek1ip1 PE=1 SV=1 0 2.443 16 2 2 2 153 18.1 9.91 2 2 1736441.281 858411.3125 1466411 2 1 2 Met-loss+Acetyl [N-Term] metabolic process metal ion binding Pf13917 67288 ENSMUSG00000021716.14 Srek1ip1 13 0 High Q8N7N5 DDB1- and CUL4-associated factor 8 OS=Mus musculus OX=10090 GN=Dcaf8 PE=1 SV=1 0 5.188 5 2 2 2 591 66 5.87 2 2 1038153.75 1 metabolic process cytoplasm;cytosol;mitochondrion;nucleus protein binding Pf00400 98193 ENSMUSG00000026554.15 Dcaf8 1 Neddylation 0 Low A8DIL0 Galectin OS=Mus musculus OX=10090 GN=Lgals8 PE=1 SV=1 0.061 0.769 2 1 2 1 325 37 8.95 1 2 8634857 12630647 8696197 9820244 1 1 1 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding Pf00337 56048 ENSMUSG00000057554.13 Lgals8 13 0 High E9PVB5 Tetratricopeptide repeat protein 17 OS=Mus musculus OX=10090 GN=Ttc17 PE=1 SV=1 0 5.845 4 2 2 2 1198 135.4 6.47 2 2 62236.48047 185704.5 1781588.563 1 1 2 cell organization and biogenesis cytoplasm;cytoskeleton;cytosol;membrane catalytic activity;nucleotide binding;protein binding "Pf00515, Pf02841, Pf13414, Pf13424, Pf13432" 74569 ENSMUSG00000027194.16 Ttc17 2 0 Medium A0A338P6I2 "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Mus musculus OX=10090 GN=Polr2h PE=1 SV=1" 0.022 1.462 4 1 2 1 143 16.5 5.05 1 1 1 1 45874.53125 291003.0938 249386.2813 374918.625 1 1 1 1 0 High O09061 Proteasome subunit beta type-1 OS=Mus musculus OX=10090 GN=Psmb1 PE=1 SV=1 0 4.054 8 2 2 2 240 26.4 7.81 2 2 436622.0313 216559.9063 338053.0938 1 1 1 metabolic process cytoplasm;cytosol;nucleus;proteasome catalytic activity Pf00227 19170 ENSMUSG00000014769.9 Psmb1 17 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome 0 High Q6ZQ38 Cullin-associated NEDD8-dissociated protein 1 OS=Mus musculus OX=10090 GN=Cand1 PE=1 SV=2 0 2.596 1 2 2 2 1230 136.2 5.78 2 2 48799.94141 353644.375 301838.3516 703519.875 1 2 2 2 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;membrane;nucleus protein binding "Pf08623, Pf12755, Pf13513" 71902 ENSMUSG00000020114.12 Cand1 10 Neddylation; Neutrophil degranulation; Iron uptake and transport 0 High Q8BG51 Mitochondrial Rho GTPase 1 OS=Mus musculus OX=10090 GN=Rhot1 PE=1 SV=1 0 2.94 4 2 2 2 631 72.2 6.49 2 2 29473.36328 101812.5156 101317.5 1029487.719 1 1 1 2 cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf00071, Pf08355, Pf08356, Pf08477" 59040 ENSMUSG00000017686.16 Rhot1 11 Ub-specific processing proteases; Rho GTPase cycle 0 Medium A2AMI7 Eukaryotic translation initiation factor 4 gamma 3 (Fragment) OS=Mus musculus OX=10090 GN=Eif4g3 PE=1 SV=1 0.032 1.244 1 1 2 1 1002 113.1 5.71 1 1 1 1 3708392 3214275.75 2402057.25 1 1 1 metabolic process;regulation of biological process protein binding;RNA binding "Pf02020, Pf02847, Pf02854" 230861 ENSMUSG00000028760.16 Eif4g3 4 ISG15 antiviral mechanism 0 High Q80ZJ2 Inositol-1-monophosphatase OS=Mus musculus OX=10090 GN=Impa1 PE=1 SV=1 0 2.388 4 1 2 1 276 29.9 4.82 1 1 1 1 92172.39063 157897.3281 144576.7344 375144.75 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm catalytic activity;metal ion binding;protein binding Pf00459 55980 ENSMUSG00000027531.16 Impa1 3 "Synthesis of IP2, IP, and Ins in the cytosol" 0 High Q3V1T4 Prolyl 3-hydroxylase 1 OS=Mus musculus OX=10090 GN=P3h1 PE=1 SV=2 0 4.811 3 2 2 2 739 83.6 5.14 2 2 341800 512293.6563 497521.1563 589372.25 1 1 1 1 cell growth;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;extracellular;membrane;nucleus catalytic activity;metal ion binding;protein binding Pf13640 56401 ENSMUSG00000028641.16 Lepre1; P3h1 4 Collagen biosynthesis and modifying enzymes 0 Medium P81122 Insulin receptor substrate 2 OS=Mus musculus OX=10090 GN=Irs2 PE=1 SV=2 0.032 1.213 1 1 2 1 1321 136.7 8.69 1 1 1 1 203354.1406 411688.6875 434711.0938 542147.6875 1 1 1 1 cell proliferation;cellular homeostasis;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane protein binding;signal transducer activity "Pf00169, Pf02174, Pf15413" 384783 ENSMUSG00000038894.7 Irs2 8 "RET signaling; PI3K Cascade; Signal attenuation; Interleukin-7 signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interleukin-20 family signaling; Signaling by Leptin; IRS activation; Signaling by Leptin; RAF/MAP kinase cascade; SOS-mediated signalling; Mus musculus biological processes; PI3K/AKT activation" FoxO signaling pathway; Type II diabetes mellitus; MicroRNAs in cancer; Regulation of lipolysis in adipocytes; Insulin signaling pathway; Insulin resistance; Longevity regulating pathway; Non-alcoholic fatty liver disease (NAFLD); cGMP-PKG signaling pathway; Adipocytokine signaling pathway; AMPK signaling pathway; Longevity regulating pathway - multiple species 0 High Q5SV80 Unconventional myosin-XIX OS=Mus musculus OX=10090 GN=Myo19 PE=1 SV=1 0 5.628 3 2 2 2 963 108 7.9 2 2 952297.125 2 cellular component movement;regulation of biological process cytoplasm;cytoskeleton;membrane;mitochondrion catalytic activity;motor activity;nucleotide binding;protein binding "Pf00063, Pf00612" 66196 ENSMUSG00000020527.14 Myo19 11 0 High Q3ULL6 UPF3 regulator of nonsense transcripts homolog B (yeast) OS=Mus musculus OX=10090 GN=Upf3b PE=1 SV=1 0 3.446 5 1 2 1 472 57 9.44 1 1 1 1 196128.9219 223631.2344 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus RNA binding Pf03467 68134 ENSMUSG00000036572.16 Upf3b X mRNA Splicing - Major Pathway; mRNA 3'-end processing; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA surveillance pathway; RNA transport 0 Medium A2A432 Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 0.019 1.587 1 1 2 1 970 110.6 8.37 1 2 119802.0938 213394.0469 1940055 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;nucleus catalytic activity;DNA binding;protein binding "Pf00888, Pf10557" 72584 ENSMUSG00000031095.15 Cul4b X Dual incision in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Nucleotide excision repair 0 High P63037 DnaJ homolog subfamily A member 1 OS=Mus musculus OX=10090 GN=Dnaja1 PE=1 SV=1 0 6.929 7 2 2 2 397 44.8 7.08 2 2 1291698.25 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 15502 ENSMUSG00000028410.13 Dnaja1 4 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High Q8CGY8 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Mus musculus OX=10090 GN=Ogt PE=1 SV=2 0 6.885 2 2 2 2 1046 116.9 6.7 2 2 301288.1563 488781.1563 1 1 cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;protein binding "Pf00515, Pf04184, Pf07719, Pf13176, Pf13181, Pf13374, Pf13414, Pf13424, Pf13428, Pf13429, Pf13431, Pf13432, Pf13844, Pf14559" 108155 ENSMUSG00000034160.13 Ogt X HATs acetylate histones; UCH proteinases Insulin resistance; Other types of O-glycan biosynthesis 0 High P06339 "H-2 class I histocompatibility antigen, D-37 alpha chain OS=Mus musculus OX=10090 GN=H2-T23 PE=1 SV=1" 0 6.135 5 2 2 1 357 40.8 6.35 2 2 608018.125 1 defense response;regulation of biological process;response to stimulus cell surface;membrane protein binding "Pf00129, Pf07654" 15040 ENSMUSG00000067212.8 H2-T23 17 Endocytosis; Herpes simplex infection; Allograft rejection; Epstein-Barr virus infection; Cell adhesion molecules (CAMs); HTLV-I infection; Phagosome; Graft-versus-host disease; Viral myocarditis; Antigen processing and presentation; Type I diabetes mellitus; Natural killer cell mediated cytotoxicity; Autoimmune thyroid disease; Viral carcinogenesis 0 High Q9CQL1 Protein mago nashi homolog 2 OS=Mus musculus OX=10090 GN=Magohb PE=2 SV=1 0.01 1.912 10 1 2 1 146 17.1 6.39 1 1 1 1 642924.5 436087.4688 368592.7813 1 1 1 metabolic process;transport nucleus;spliceosomal complex RNA binding Pf02792 66441 Magohb 6 mRNA surveillance pathway; Spliceosome; RNA transport 0 Medium E9Q3W4 Plectin OS=Mus musculus OX=10090 GN=Plec PE=1 SV=1 0.036 1.141 0 1 2 1 4386 498.8 5.68 1 1 1 1 312353.9063 407535.125 552516.8125 388181.5313 1 1 1 1 cell organization and biogenesis;response to stimulus cytoplasm;cytoskeleton;cytosol;membrane protein binding;RNA binding;structural molecule activity "Pf00307, Pf00681, Pf07812, Pf11971" 18810 ENSMUSG00000022565.15 Plec 15 0 High P03899 NADH-ubiquinone oxidoreductase chain 3 OS=Mus musculus OX=10090 GN=Mtnd3 PE=1 SV=3 0 2.757 13 1 2 1 115 13.2 4.64 1 2 682233.875 1 metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity Pf00507 17718; 3338896 ENSMUSG00000064360.1 ND3 MT Complex I biogenesis Metabolic pathways; Oxidative phosphorylation; Parkinson's disease 0 High O35658 "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Mus musculus OX=10090 GN=C1qbp PE=1 SV=1" 0 5.027 5 1 2 1 278 31 4.92 1 2 301109.5625 830918.1875 1 1 cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen protein binding;RNA binding Pf02330 12261 C1qbp 11 0 High Q8R1S0 "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Mus musculus OX=10090 GN=Coq6 PE=1 SV=3" 0.007 2.055 2 1 2 1 476 51.4 7.17 1 2 29320.45117 96868.92188 124664.6641 1129121.625 1 1 1 1 metabolic process Golgi;membrane;mitochondrion catalytic activity;nucleotide binding Pf01494 217707 ENSMUSG00000021235.13 Coq6 12 Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways 0 High Q6P4T2 U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Mus musculus OX=10090 GN=Snrnp200 PE=1 SV=1 0 2.388 0 1 2 1 2136 244.4 6.06 1 1 1 1 391255.625 405056.375 418491.5313 515145.875 1 1 1 1 cell differentiation;metabolic process membrane;nucleus;spliceosomal complex catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding "Pf00270, Pf00271, Pf02889, Pf04851" 320632 ENSMUSG00000003660.10 Snrnp200 2 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway Spliceosome 0 Medium Q4VBD9 GDNF-inducible zinc finger protein 1 OS=Mus musculus OX=10090 GN=Gzf1 PE=1 SV=2 0.013 1.788 1 1 2 1 706 79.5 7.97 1 1 1 1 309502.1875 237338.5625 338262.0625 1 1 1 metabolic process;regulation of biological process cytoplasm;nucleus DNA binding;metal ion binding;protein binding "Pf00651, Pf13465" 74533 ENSMUSG00000027439.9 Gzf1 2 0 High Q61586 "Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Mus musculus OX=10090 GN=Gpam PE=1 SV=2" 0 4.975 3 2 2 2 827 93.6 7.84 2 2 290831.5938 358368.3125 376927 1121612.594 1 1 1 2 defense response;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity Pf01553 14732 ENSMUSG00000024978.10 Gpam 19 Triglyceride biosynthesis; Synthesis of PA Metabolic pathways; Glycerophospholipid metabolism; Glycerolipid metabolism 0 High G3UZX4 Casein kinase II subunit beta OS=Mus musculus OX=10090 GN=Csnk2b PE=1 SV=1 0 4.032 4 1 2 1 257 29.2 6.25 1 1 1 1 427109.6563 358442.7813 538668.875 1 1 1 metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus catalytic activity;enzyme regulator activity;metal ion binding;protein binding Pf01214 13001 ENSMUSG00000024387.13 Csnk2b 17 0 High P63094 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short OS=Mus musculus OX=10090 GN=Gnas PE=1 SV=1 0 2.383 3 1 2 1 394 45.6 5.96 1 1 1 1 253264.7031 702812.75 641530.125 637773.375 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endosome;extracellular;Golgi;membrane;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00503, Pf08477" 14683 ENSMUSG00000027523.19 Gnas 2 PKA activation in glucagon signalling; Prostacyclin signalling through prostacyclin receptor; Hedgehog 'off' state; Glucagon-type ligand receptors; G alpha (s) signalling events; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Oxytocin signaling pathway; Morphine addiction; Chagas disease (American trypanosomiasis); Phospholipase D signaling pathway; Pancreatic secretion; Dopaminergic synapse; Regulation of lipolysis in adipocytes; Ovarian steroidogenesis; Amphetamine addiction; Endocrine and other factor-regulated calcium reabsorption; Platelet activation; Melanogenesis; Dilated cardiomyopathy; Thyroid hormone synthesis; Glutamatergic synapse; Cocaine addiction; Long-term depression; Rap1 signaling pathway; Pathways in cancer; Calcium signaling pathway; Bile secretion; Salivary secretion; Alcoholism; cAMP signaling pathway; Vascular smooth muscle contraction; Aldosterone synthesis and secretion; GnRH signaling pathway; Vasopressin-regulated water reabsorption; Gastric acid secretion; Renin secretion; Gap junction; Circadian entrainment; Insulin secretion; Estrogen signaling pathway; Amoebiasis; Glucagon signaling pathway; Serotonergic synapse; Adrenergic signaling in cardiomyocytes; Endocrine resistance; Inflammatory mediator regulation of TRP channels 0 High A0A5H1ZRL7 Transformation-related protein 53-binding protein 1 OS=Mus musculus OX=10090 GN=Trp53bp1 PE=1 SV=1 0 2.847 2 2 2 2 1919 207.5 4.59 2 2 692558.6719 641978.5313 610613.0156 2 2 2 0 High P49717 DNA replication licensing factor MCM4 OS=Mus musculus OX=10090 GN=Mcm4 PE=1 SV=1 0 3.528 2 1 2 1 862 96.7 7.2 1 1 1 1 92592.65625 245609.9531 257427.1406 378369.0313 1 1 1 1 metabolic process membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00493, Pf07728, Pf14551" 17217 ENSMUSG00000022673.4 Mcm4 16 Removal of licensing factors from origins; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Orc1 removal from chromatin; M/G1 Transition; Activation of ATR in response to replication stress; Regulation of DNA replication DNA replication; Cell cycle 0 Medium G3X8T3 Carboxypeptidase OS=Mus musculus OX=10090 GN=Ctsa PE=1 SV=1 0.021 1.526 2 1 2 1 492 55.7 5.87 1 1 1 1 288156.0625 546416.5 253539.9219 1 1 1 metabolic process;regulation of biological process membrane;mitochondrion;vacuole catalytic activity;protein binding Pf00450 19025 ENSMUSG00000017760.15 Ctsa 2 0 High A0A494B909 "Peroxisomal 2,4-dienoyl-CoA reductase OS=Mus musculus OX=10090 GN=Decr2 PE=1 SV=1" 0 5.742 7 2 2 2 351 37.8 8.4 2 2 85068.45313 2498292 1 2 0 High O70546 Lysine-specific demethylase 6A OS=Mus musculus OX=10090 GN=Kdm6a PE=1 SV=2 0 4.481 2 2 2 2 1401 154.3 7.39 1 1 1 1 107947.7813 247314.6094 194971.1875 182680.6094 1 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding "Pf00515, Pf02373, Pf05109, Pf13414, Pf13424, Pf13431, Pf13432" 22289 ENSMUSG00000037369.16 Kdm6a X HDMs demethylate histones Transcriptional misregulation in cancer 0 High I7HLV5 Novel protein (Fragment) OS=Mus musculus OX=10090 GN=Fam3a PE=1 SV=1 0 5.247 10 2 2 2 199 21.8 8.28 2 2 1809229.5 2 defense response;response to stimulus extracellular;membrane 66294 ENSMUSG00000031399.15 Fam3a X 0 High Q3UNH6 Cyclic AMP-responsive element-binding protein 3 OS=Mus musculus OX=10090 GN=Creb3 PE=2 SV=1 0 4.805 3 1 2 1 379 42.4 4.98 1 2 94152.53906 1426882.375 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf07716" 12913 ENSMUSG00000028466.15 Creb3 4 CREB3 factors activate genes Cholinergic synapse; Dopaminergic synapse; TNF signaling pathway; Amphetamine addiction; Insulin resistance; Melanogenesis; Hepatitis B; Thyroid hormone synthesis; Longevity regulating pathway; Huntington's disease; Cocaine addiction; cGMP-PKG signaling pathway; Alcoholism; PI3K-Akt signaling pathway; cAMP signaling pathway; AMPK signaling pathway; Aldosterone synthesis and secretion; Vasopressin-regulated water reabsorption; Insulin secretion; Estrogen signaling pathway; Glucagon signaling pathway; Viral carcinogenesis; Adrenergic signaling in cardiomyocytes; Prostate cancer 0 High Q8BVQ9 26S proteasome regulatory subunit 7 OS=Mus musculus OX=10090 GN=Psmc2 PE=1 SV=1 0 5.984 4 2 2 2 475 52.8 6.28 2 2 191062.9375 989995.5938 1 2 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus;proteasome catalytic activity;nucleotide binding;protein binding "Pf00004, Pf00158, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401" 19181 ENSMUSG00000028932.7 Psmc2 5 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 High F6Q269 JmjC domain-containing protein 8 OS=Mus musculus OX=10090 GN=Jmjd8 PE=1 SV=2 0 3.664 7 1 2 1 186 20.9 7.3 1 2 0 High Q8BJU0 Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Mus musculus OX=10090 GN=Sgta PE=1 SV=2 0 3.963 3 1 2 1 315 34.3 5.06 1 1 1 1 304245.6875 238841.9219 492558.9688 1 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus protein binding "Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559" 52551 ENSMUSG00000004937.6 Sgta 10 0 High O89112 Glutathione S-transferase LANCL1 OS=Mus musculus OX=10090 GN=Lancl1 PE=1 SV=1 0 4.669 3 1 2 1 399 45.3 7.77 1 1 1 1 320362.0938 491415.4063 764754.625 306573.4063 1 1 2 1 regulation of biological process;response to stimulus cytoplasm;membrane metal ion binding;protein binding Pf05147 14768 ENSMUSG00000026000.16 Lancl1 1 0 High Q7TMF3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 OS=Mus musculus OX=10090 GN=Ndufa12 PE=1 SV=2 0 4.444 24 2 2 2 145 17.1 9.36 2 2 metabolic process;response to stimulus;transport cytosol;membrane;mitochondrion catalytic activity Pf05071 66414 ENSMUSG00000020022.16 Ndufa12 10 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q91YM4 FAST kinase domain-containing protein 4 OS=Mus musculus OX=10090 GN=Tbrg4 PE=1 SV=1 0 5.736 4 2 2 2 630 71.5 8.34 2 2 38635.75391 116087.9609 144066.4844 1039870.875 1 1 1 2 metabolic process mitochondrion catalytic activity;RNA binding "Pf06743, Pf08368, Pf08373" 21379 ENSMUSG00000000384.15 Tbrg4 11 0 High P26369 Splicing factor U2AF 65 kDa subunit OS=Mus musculus OX=10090 GN=U2af2 PE=1 SV=3 0 6.118 6 2 2 2 475 53.5 9.09 2 2 295165.5313 2573893.188 1852246.906 1791973.563 1 2 2 2 metabolic process;regulation of biological process nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 22185 ENSMUSG00000030435.16 U2af2 7 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Spliceosome 0 High Q5H8C4 Vacuolar protein sorting-associated protein 13A OS=Mus musculus OX=10090 GN=Vps13a PE=1 SV=1 0 9.602 1 2 2 2 3166 359.2 6.19 2 2 141513.0781 1130611.375 1 2 metabolic process;response to stimulus;transport "Pf06650, Pf12624" 271564 ENSMUSG00000046230.9 Vps13a 19 0 High Q60932 Voltage-dependent anion-selective channel protein 1 OS=Mus musculus OX=10090 GN=Vdac1 PE=1 SV=3 0 4.417 4 1 2 1 296 32.3 8.43 1 1 1 1 205114.875 498460.75 601750.5625 640924.9375 1 1 1 1 cell communication;cell death;cell differentiation;defense response;regulation of biological process;response to stimulus;transport membrane;mitochondrion;nucleus nucleotide binding;protein binding;transporter activity Pf01459 22333 ENSMUSG00000020402.11 Vdac1 11 Pink/Parkin Mediated Mitophagy NOD-like receptor signaling pathway; HTLV-I infection; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway; Influenza A 0 High Q9CQZ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Mus musculus OX=10090 GN=Ndufa6 PE=1 SV=1 0 5.599 19 2 2 2 131 15.3 10.11 2 2 1387566.75 1 metabolic process;response to stimulus;transport membrane;mitochondrion "Pf05347, Pf13232, Pf13233" 67130 ENSMUSG00000022450.5 Ndufa6 15 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q9DCT2 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs3 PE=1 SV=2" 0 8.97 10 2 2 2 263 30.1 7.17 1 1 1 1 749113.7031 596904 3499905.875 2 2 2 metabolic process;regulation of biological process;transport membrane;mitochondrion catalytic activity Pf00329 68349 ENSMUSG00000005510.9; ENSMUSG00000111727.1 Ndufs3 2; CHR_MG191_PATCH Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High P61965 WD repeat-containing protein 5 OS=Mus musculus OX=10090 GN=Wdr5 PE=1 SV=1 0 3.533 9 2 2 2 334 36.6 8.27 1 1 1 1 1509567.297 188610.9531 145259.7344 2 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus catalytic activity;protein binding "Pf00400, Pf08662, Pf11715" 140858 ENSMUSG00000026917.15 Wdr5 2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Neddylation; RMTs methylate histone arginines; HATs acetylate histones; PKMTs methylate histone lysines 0 High P59266 Fat storage-inducing transmembrane protein 2 OS=Mus musculus OX=10090 GN=Fitm2 PE=1 SV=1 0 4.905 8 2 2 2 262 30 9 2 2 1538583.25 2 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process endoplasmic reticulum;membrane;mitochondrion Pf10261 228859 ENSMUSG00000048486.6 Fitm2 2 Lipid particle organization 0 High Q8BXQ2 GPI transamidase component PIG-T OS=Mus musculus OX=10090 GN=Pigt PE=1 SV=2 0 2.395 1 1 2 1 582 65.7 8.4 1 1 1 1 207267.9219 350869.7188 1519551.125 1 1 1 cell death;cell differentiation;metabolic process cytoplasm;endoplasmic reticulum;membrane catalytic activity Pf04113 78928 ENSMUSG00000017721.15 Pigt 2 Attachment of GPI anchor to uPAR Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways 0 High Q8BKZ9 "Pyruvate dehydrogenase protein X component, mitochondrial OS=Mus musculus OX=10090 GN=Pdhx PE=1 SV=1" 0 8.953 6 2 2 2 501 54 7.75 2 2 888248.6875 892534.75 938228.3438 2561599.25 2 2 2 2 metabolic process mitochondrion;organelle lumen catalytic activity "Pf00198, Pf00364, Pf02817" 27402 ENSMUSG00000010914.10 Pdhx 2 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Metabolic pathways 0 High O89079 Coatomer subunit epsilon OS=Mus musculus OX=10090 GN=Cope PE=1 SV=3 0 4.798 7 2 2 2 308 34.5 5.06 2 2 520235.5313 1 transport cytoplasm;Golgi;membrane protein binding;structural molecule activity Pf04733 59042 ENSMUSG00000055681.14 Cope 8 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q6PGF3 Mediator of RNA polymerase II transcription subunit 16 OS=Mus musculus OX=10090 GN=Med16 PE=2 SV=2 0 4.031 2 2 2 2 828 91.7 7.75 2 2 193031.2188 915561 1 2 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;protein binding;receptor activity "Pf00400, Pf11635" 216154 Med16 10 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High Q8VCM7 Fibrinogen gamma chain OS=Mus musculus OX=10090 GN=Fgg PE=1 SV=1 0.01 1.911 3 1 2 1 436 49.4 5.86 1 1 1 1 455430.1563 553940.625 266918.2188 1 1 1 cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport cell surface;cytoplasm;extracellular metal ion binding;protein binding;structural molecule activity "Pf00147, Pf08702" 99571 ENSMUSG00000033860.13 Fgg 3 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); p130Cas linkage to MAPK signaling for integrins; Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of TLR by endogenous ligand; Common Pathway of Fibrin Clot Formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet degranulation Staphylococcus aureus infection; Platelet activation; Complement and coagulation cascades 0 High A6PWZ2 Eukaryotic translation initiation factor 6 (Fragment) OS=Mus musculus OX=10090 GN=Eif6 PE=1 SV=1 0.004 2.133 31 1 2 1 58 6.5 6.76 1 1 1 1 358919.125 531021.0625 473120.0313 259570.2031 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;nucleus nucleotide binding;RNA binding "Pf01031, Pf01912" 16418 ENSMUSG00000027613.15 Eif6 2 0 High Q9WTS2 "Alpha-(1,6)-fucosyltransferase OS=Mus musculus OX=10090 GN=Fut8 PE=1 SV=2" 0 3.883 3 2 2 2 575 66.5 7.52 2 2 1643053.688 2 cellular component movement;metabolic process;regulation of biological process;response to stimulus cytosol;Golgi;membrane catalytic activity;protein binding "Pf00018, Pf02050, Pf14604" 53618 ENSMUSG00000021065.16 Fut8 12 Reactions specific to the complex N-glycan synthesis pathway Metabolic pathways; N-Glycan biosynthesis; Transcriptional misregulation in cancer; Glycosaminoglycan biosynthesis - keratan sulfate 0 High Q80TL7 Protein MON2 homolog OS=Mus musculus OX=10090 GN=Mon2 PE=1 SV=2 0 4.266 1 2 2 2 1715 189 6.13 2 2 70760.72656 610391.7656 1 2 transport cytosol "Pf09324, Pf12783" 67074 ENSMUSG00000034602.14 Mon2 10 0 High Q9QZS0 Collagen alpha-3(IV) chain OS=Mus musculus OX=10090 GN=Col4a3 PE=1 SV=2 0 2.518 1 1 2 1 1669 161.6 9.48 1 1 1 1 553359.4375 447944.6875 993754.6875 1 1 1 cell death;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular protein binding;structural molecule activity Pf01413 12828 ENSMUSG00000079465.8 Col4a3 1 Anchoring fibril formation; Laminin interactions; Crosslinking of collagen fibrils; Collagen chain trimerization; Integrin cell surface interactions; NCAM1 interactions; Collagen degradation; Non-integrin membrane-ECM interactions; Signaling by PDGF AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High A0A0A0MQ70 Solute carrier family 25 member 35 OS=Mus musculus OX=10090 GN=Slc25a35 PE=1 SV=1 0 5.737 7 2 2 2 296 32.1 9.52 2 2 498006.1563 1 transport membrane;mitochondrion transporter activity Pf00153 71998 ENSMUSG00000018740.14 Slc25a35 11 0 High P50247 Adenosylhomocysteinase OS=Mus musculus OX=10090 GN=Ahcy PE=1 SV=3 0 3.619 3 1 2 1 432 47.7 6.54 1 1 1 1 299273.1563 503450.0938 324578.2813 621190.9375 1 1 1 1 defense response;metabolic process;response to stimulus;transport cytoplasm;cytosol;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding "Pf00670, Pf02254, Pf02826, Pf05221" 269378; 11615 ENSMUSG00000048087.5; ENSMUSG00000027597.15 Ahcy; Gm4737 2; 16 Sulfur amino acid metabolism; Methylation Metabolic pathways; Cysteine and methionine metabolism 0 High O54962 Barrier-to-autointegration factor OS=Mus musculus OX=10090 GN=Banf1 PE=1 SV=1 0 6.27 29 2 2 2 89 10.1 6.09 1 1 1 1 173189.25 2521737.813 2691963.75 479981.7188 1 2 2 1 metabolic process;regulation of biological process chromosome;cytoplasm;cytosol;nucleus DNA binding;protein binding Pf02961 23825 ENSMUSG00000024844.14 Banf1 19 Clearance of Nuclear Envelope Membranes from Chromatin; Initiation of Nuclear Envelope Reformation; Nuclear Envelope Breakdown 0 Medium E9Q5X5 Galectin-3-binding protein (Fragment) OS=Mus musculus OX=10090 GN=Lgals3bp PE=1 SV=1 0.04 1.12 3 1 2 1 204 21.9 4.65 1 1 1 1 272144.4063 3088031.5 2501129 1556915.875 1 1 1 1 transport membrane receptor activity Pf00530 ENSMUSG00000033880.11 11 0 High Q9R013 Cathepsin F OS=Mus musculus OX=10090 GN=Ctsf PE=1 SV=1 0 7.778 5 2 2 2 462 51.6 6.55 2 2 264635.2188 828113.4375 1 1 metabolic process vacuole catalytic activity "Pf00112, Pf08246" 56464 ENSMUSG00000083282.2 Ctsf 19 MHC class II antigen presentation Lysosome; Apoptosis 0 High Q9CQ75 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Mus musculus OX=10090 GN=Ndufa2 PE=1 SV=3 0 6.676 24 2 2 2 99 10.9 9.99 2 2 271467.5 750387.6563 814210.6719 1522295.5 1 2 2 2 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity Pf05047 17991 ENSMUSG00000014294.4 Ndufa2 18 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High D6RGM8 Transmembrane 9 superfamily member OS=Mus musculus OX=10090 GN=Tm9sf1 PE=1 SV=1 0 7.419 6 2 2 2 417 47.3 6.74 2 2 301672.625 291775.5625 1301217.375 1 1 2 membrane Pf02990 ENSMUSG00000002320.15 14 0 High Q3U422 "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Mus musculus OX=10090 GN=Ndufv3 PE=1 SV=1" 0 4.987 12 2 2 2 468 50.5 8.97 2 2 330161.0859 142601.2031 136591.125 1009093.219 2 1 1 2 metabolic process;transport membrane;mitochondrion RNA binding Pf10243 78330 ENSMUSG00000024038.16 Ndufv3 17 0 Medium Q91W39 Nuclear receptor coactivator 5 OS=Mus musculus OX=10090 GN=Ncoa5 PE=1 SV=1 0.027 1.359 3 1 2 1 579 65.3 9.82 1 1 1 1 84187.48438 106067.2266 168994.3438 147714.75 1 1 1 1 metabolic process;regulation of biological process cytoskeleton;nucleus RNA binding 228869 ENSMUSG00000039804.15 Ncoa5 2 0 High Q99N93 "39S ribosomal protein L16, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl16 PE=1 SV=1" 0 7.299 8 2 2 2 251 28.8 10.27 2 2 156230 85328.82813 919243.5313 1 1 2 cell organization and biogenesis;metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf00252 94063 ENSMUSG00000024683.5 Mrpl16 19 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High A0A0R4J1J1 Probable hydrolase PNKD OS=Mus musculus OX=10090 GN=Pnkd PE=1 SV=1 0.008 1.985 12 1 2 1 142 15.6 10.27 1 2 278612.625 227381.3906 1995215.625 1 1 1 metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;nucleus catalytic activity;metal ion binding;protein binding 56695 ENSMUSG00000026179.14 Pnkd 1 0 High P17665 "Cytochrome c oxidase subunit 7C, mitochondrial OS=Mus musculus OX=10090 GN=Cox7c PE=1 SV=1" 0.007 2.051 14 1 2 1 63 7.3 11 1 1 1 1 128850.3047 492141.9688 456613.8125 3448522.25 1 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02935 12867; 654359; 102642884 ENSMUSG00000017778.14 Cox7c; Gm12338; LOC100048613; LOC102642884 13; 11; 2 Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High E9Q7G1 Transmembrane p24-trafficking protein 7 OS=Mus musculus OX=10090 GN=Tmed7 PE=1 SV=1 0 2.765 7 1 1 1 188 21.3 6.2 1 1 679595.4375 1 transport endoplasmic reticulum;Golgi;membrane Pf01105 ENSMUSG00000033184.14 18 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 High Q9D6J6 "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Mus musculus OX=10090 GN=Ndufv2 PE=1 SV=2" 0 2.378 4 1 1 1 248 27.3 7.4 1 1 102861.2891 455688.1563 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;metal ion binding Pf01257 72900 ENSMUSG00000024099.14 Ndufv2 17 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Medium O89017 Legumain OS=Mus musculus OX=10090 GN=Lgmn PE=1 SV=1 0.027 1.399 3 1 1 1 435 49.3 6.39 1 1 metabolic process;regulation of biological process;response to stimulus endosome;vacuole catalytic activity Pf01650 19141 ENSMUSG00000021190.14 Lgmn 12 MHC class II antigen presentation; Vitamin D (calciferol) metabolism; Trafficking and processing of endosomal TLR Lysosome; Antigen processing and presentation 0 High Q9D819 Inorganic pyrophosphatase OS=Mus musculus OX=10090 GN=Ppa1 PE=1 SV=1 0 2.451 3 1 1 1 289 32.6 5.6 1 1 186937.1875 173450.0469 181430.1875 565031.75 1 1 1 1 metabolic process cytoplasm catalytic activity;metal ion binding Pf00719 67895 ENSMUSG00000020089.8 Ppa1 10 Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis Oxidative phosphorylation 0 High P01887 Beta-2-microglobulin OS=Mus musculus OX=10090 GN=B2m PE=1 SV=2 0 3.353 8 1 1 1 119 13.8 8.44 1 1 297468 269426 1754567.375 1 1 1 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport cytosol;extracellular;Golgi;membrane protein binding Pf07654 12010 ENSMUSG00000060802.8 B2m 2 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 signaling" Antigen processing and presentation 0 High P60603 Reactive oxygen species modulator 1 OS=Mus musculus OX=10090 GN=Romo1 PE=2 SV=1 0 2.455 23 1 1 1 79 8.2 9.33 1 1 Met-loss [N-Term] defense response;regulation of biological process;response to stimulus membrane;mitochondrion Pf10247 67067 ENSMUSG00000067847.13 Romo1 2 0 High Q8BM72 Heat shock 70 kDa protein 13 OS=Mus musculus OX=10090 GN=Hspa13 PE=1 SV=1 0 3.209 3 1 1 1 471 51.7 5.63 1 1 421446.5938 1 cell organization and biogenesis endoplasmic reticulum nucleotide binding "Pf00012, Pf06723" 110920 ENSMUSG00000032932.14 Hspa13 16 0 High P15208 Insulin receptor OS=Mus musculus OX=10090 GN=Insr PE=1 SV=2 0.007 2.02 1 1 1 1 1372 155.5 5.95 1 1 406553.625 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytosol;endosome;membrane;nucleus;organelle lumen catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00041, Pf00069, Pf00757, Pf01030, Pf07714, Pf14843" 16337 ENSMUSG00000005534.10 Insr 8 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; IRS activation; Signal attenuation; Insulin receptor recycling" FoxO signaling pathway; mTOR signaling pathway; Phospholipase D signaling pathway; Type II diabetes mellitus; Ras signaling pathway; Regulation of lipolysis in adipocytes; Ovarian steroidogenesis; Insulin signaling pathway; Insulin resistance; Longevity regulating pathway; Adherens junction; Non-alcoholic fatty liver disease (NAFLD); cGMP-PKG signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway - multiple species; Aldosterone-regulated sodium reabsorption 0 High P35487 "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha2 PE=1 SV=1" 0 2.543 3 1 1 1 391 43.4 8.5 1 1 789466 434448.25 1129989.75 1 1 1 metabolic process mitochondrion;organelle lumen catalytic activity Pf00676 18598 ENSMUSG00000047674.2 Pdha2 3 Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway 0 High Q8K5B2 Multiple coagulation factor deficiency protein 2 homolog OS=Mus musculus OX=10090 GN=Mcfd2 PE=1 SV=1 0.008 1.974 12 1 1 1 145 16.2 4.72 1 1 501230.7188 1 metabolic process;regulation of biological process;transport endoplasmic reticulum;extracellular;Golgi metal ion binding Pf13499 193813 ENSMUSG00000024150.11 Mcfd2 17 COPII (Coat Protein 2) Mediated Vesicle Transport; Cargo concentration in the ER 0 High P97299 Secreted frizzled-related protein 2 OS=Mus musculus OX=10090 GN=Sfrp2 PE=1 SV=2 0 2.819 4 1 1 1 295 33.4 7.61 1 1 16194791 18302108 24090370 9412770 1 1 1 1 cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding;receptor activity;signal transducer activity "Pf01392, Pf01759" 20319 ENSMUSG00000027996.13 Sfrp2 3 Wnt signaling pathway 0 Low Q66JY2 INO80 complex subunit D OS=Mus musculus OX=10090 GN=Ino80d PE=2 SV=4 0.059 0.801 3 1 1 1 1021 112.3 7.78 1 1 0 High Q8BYB9 Protein O-glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Poglut1 PE=1 SV=2 0 3.07 3 1 1 1 392 46.4 8.85 1 1 358573.0313 1 development;metabolic process;regulation of biological process endoplasmic reticulum;organelle lumen catalytic activity;protein binding Pf05686 224143 ENSMUSG00000034064.14 Poglut1 16 Other types of O-glycan biosynthesis 0 High P52850 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 OS=Mus musculus OX=10090 GN=Ndst2 PE=1 SV=1 0 3.305 1 1 1 1 883 101.1 8.7 1 1 431561.5938 1 metabolic process;regulation of biological process Golgi;membrane catalytic activity "Pf00685, Pf12062" 17423 ENSMUSG00000039308.5 Ndst2 14 HS-GAG biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 High Q9QYJ0 DnaJ homolog subfamily A member 2 OS=Mus musculus OX=10090 GN=Dnaja2 PE=1 SV=1 0.01 1.882 2 1 1 1 412 45.7 6.48 1 1 183447.6094 550052.0625 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;membrane;nucleus enzyme regulator activity;metal ion binding;nucleotide binding;protein binding "Pf00226, Pf00684, Pf01556" 56445 ENSMUSG00000031701.6 Dnaja2 8 HSP90 chaperone cycle for steroid hormone receptors (SHR) Protein processing in endoplasmic reticulum 0 High O55029 Coatomer subunit beta' OS=Mus musculus OX=10090 GN=Copb2 PE=1 SV=2 0 2.274 1 1 1 1 905 102.4 5.3 1 1 307625.0313 1 transport cytoplasm;cytosol;Golgi;membrane protein binding;structural molecule activity "Pf00400, Pf04053" 50797 ENSMUSG00000032458.6 Copb2 9 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 Medium Q9JIF3 "Solute carrier family 2, facilitated glucose transporter member 8 OS=Mus musculus OX=10090 GN=Slc2a8 PE=1 SV=2" 0.021 1.554 3 1 1 1 477 51.5 8.29 1 1 714589.75 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport membrane transporter activity "Pf00083, Pf07690" 56017 ENSMUSG00000026791.14 Slc2a8 2 Cargo recognition for clathrin-mediated endocytosis; Cellular hexose transport 0 Medium Q5ND52 "rRNA methyltransferase 3, mitochondrial OS=Mus musculus OX=10090 GN=Mrm3 PE=2 SV=1" 0.023 1.425 1 1 1 1 418 46.8 9.39 1 1 290841.75 1 metabolic process mitochondrion catalytic activity;RNA binding "Pf00588, Pf08032" 67390 ENSMUSG00000038046.4 Rnmtl1; Mrm3 11 0 Low Q8CFS6 Potassium voltage-gated channel subfamily V member 2 OS=Mus musculus OX=10090 GN=Kcnv2 PE=2 SV=1 0.059 0.807 1 1 1 1 562 64.4 6.2 1 1 872937.625 1 cell organization and biogenesis;regulation of biological process;transport membrane transporter activity "Pf00520, Pf02214, Pf07885" 240595 ENSMUSG00000047298.3 Kcnv2 19 Voltage gated Potassium channels 0 High Q9EQP2 EH domain-containing protein 4 OS=Mus musculus OX=10090 GN=Ehd4 PE=1 SV=1 0 4.743 2 1 1 1 541 61.4 6.76 1 1 182089.9375 674525 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport endoplasmic reticulum;endosome;membrane metal ion binding;nucleotide binding;protein binding "Pf00350, Pf01926, Pf12763" 98878 ENSMUSG00000027293.13 Ehd4 2 Endocytosis 0 High Q9D0F3 Protein ERGIC-53 OS=Mus musculus OX=10090 GN=Lman1 PE=1 SV=1 0 3.262 2 1 1 1 517 57.8 6.34 1 1 401780.6563 299699.2188 428491.125 661835.9375 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane metal ion binding;protein binding Pf03388 70361 ENSMUSG00000041891.15 Lman1 18 COPII (Coat Protein 2) Mediated Vesicle Transport; Cargo concentration in the ER Protein processing in endoplasmic reticulum 0 High P27046 Alpha-mannosidase 2 OS=Mus musculus OX=10090 GN=Man2a1 PE=1 SV=2 0.004 2.132 1 1 1 1 1150 131.5 8.03 1 1 302799.5938 1 cell organization and biogenesis;metabolic process;regulation of biological process Golgi;membrane catalytic activity;metal ion binding "Pf01074, Pf03065, Pf07748, Pf09261" 17158 ENSMUSG00000024085.13 Man2a1 17 Reactions specific to the complex N-glycan synthesis pathway Metabolic pathways; N-Glycan biosynthesis 0 High Q9Z2X2 26S proteasome non-ATPase regulatory subunit 10 OS=Mus musculus OX=10090 GN=Psmd10 PE=1 SV=3 0 2.325 3 1 1 1 231 25.1 6.06 1 1 44160.19141 152270.6719 126491.1563 654976.3125 1 1 1 1 cell death;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton;cytosol;nucleus;proteasome protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 53380 ENSMUSG00000031429.14 Psmd10 X The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Degradation of GLI1 by the proteasome; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN 0 Medium A0A571BEC9 Perilipin-4 OS=Mus musculus OX=10090 GN=Plin4 PE=1 SV=1 0.034 1.196 1 1 1 1 1601 158.6 8.76 1 1 1263270.625 1952671.5 1483260.375 1562907.5 1 1 1 1 0 High Q80UY2 E3 ubiquitin-protein ligase KCMF1 OS=Mus musculus OX=10090 GN=Kcmf1 PE=1 SV=1 0 3.334 4 1 1 1 381 41.8 5.76 1 1 9540.28125 20947.35156 71851.625 1 1 1 metabolic process catalytic activity;metal ion binding "Pf00569, Pf05605" 74287 ENSMUSG00000055239.10 Kcmf1 6 Neutrophil degranulation 0 High Q8BPT6 Mitochondrial inner membrane protease subunit 2 OS=Mus musculus OX=10090 GN=Immp2l PE=1 SV=1 0 2.319 6 1 1 1 175 19.6 9.54 1 1 659292.6875 1 cell organization and biogenesis;metabolic process;response to stimulus membrane;mitochondrion catalytic activity "Pf00717, Pf10502" 93757 ENSMUSG00000056899.10 Immp2l 12 Protein export 0 Medium E9PVX6 Proliferation marker protein Ki-67 OS=Mus musculus OX=10090 GN=Mki67 PE=1 SV=1 0.014 1.768 0 1 1 1 3177 350.7 9.72 1 1 265507.9063 250426.375 93779.46875 1 1 1 cell proliferation;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;membrane;nucleus DNA binding;nucleotide binding;protein binding;RNA binding "Pf00498, Pf08065, Pf15276" 17345 ENSMUSG00000031004.8 Mki67 7 0 High O35218 Cleavage and polyadenylation specificity factor subunit 2 OS=Mus musculus OX=10090 GN=Cpsf2 PE=1 SV=1 0 2.864 2 1 1 1 782 88.3 5.11 1 1 435638.625 1 metabolic process membrane;nucleus RNA binding "Pf00753, Pf07521, Pf10996, Pf12706, Pf13299" 51786 ENSMUSG00000041781.8 Cpsf2 12 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Processing of Intronless Pre-mRNAs; Cleavage of Growing Transcript in the Termination Region mRNA surveillance pathway 0 Medium Q61249 Immunoglobulin-binding protein 1 OS=Mus musculus OX=10090 GN=Igbp1 PE=1 SV=1 0.023 1.43 2 1 1 1 340 38.9 6.18 1 1 68023.8125 308046.1563 1 1 regulation of biological process;response to stimulus cytoplasm;cytosol enzyme regulator activity;protein binding Pf04177 18518 ENSMUSG00000031221.7 Igbp1 X 0 Medium Q3U4G3 Xyloside xylosyltransferase 1 OS=Mus musculus OX=10090 GN=Xxylt1 PE=1 SV=2 0.047 1.059 2 1 1 1 392 43.8 7.78 1 1 180187.0938 1 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding;protein binding Pf01501 268880 ENSMUSG00000047434.13 AI480653; Xxylt1 16 0 High Q9CU62 Structural maintenance of chromosomes protein 1A OS=Mus musculus OX=10090 GN=Smc1a PE=1 SV=4 0 4.798 1 1 1 1 1233 143.1 7.64 1 1 92805.24219 67569.50781 296492.25 1 1 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;nucleus nucleotide binding;protein binding;RNA binding "Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558" 24061 ENSMUSG00000041133.11 Smc1a X Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Meiotic Synapsis; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Mus musculus biological processes; SUMOylation of DNA damage response and repair proteins Oocyte meiosis; Cell cycle 0 Medium Q8R4E9 DNA replication factor Cdt1 OS=Mus musculus OX=10090 GN=Cdt1 PE=1 SV=1 0.028 1.302 1 1 1 1 557 61.5 9.57 1 1 180179.9375 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus DNA binding;protein binding Pf08839 67177 ENSMUSG00000006585.3 Cdt1 8 Removal of licensing factors from origins; Activation of the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; M/G1 Transition; Association of licensing factors with the pre-replicative complex; Regulation of DNA replication 0 Medium Q9DB25 Dolichyl-phosphate beta-glucosyltransferase OS=Mus musculus OX=10090 GN=Alg5 PE=1 SV=1 0.022 1.506 4 1 1 1 324 36.8 8.6 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00535, Pf10111, Pf13641" 66248 ENSMUSG00000036632.9 Alg5 3 Synthesis of dolichyl-phosphate-glucose Metabolic pathways; N-Glycan biosynthesis 0 Low A2AVA0 "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1" 0.06 0.798 0 1 1 1 3567 387.2 5.57 1 1 40639.13281 107752.9531 825352.6875 1 1 1 cytoplasm;extracellular;membrane metal ion binding;protein binding "Pf00008, Pf00084, Pf00092, Pf00354, Pf02210, Pf02494, Pf07645, Pf07699, Pf12947, Pf13385, Pf13519" 64817 ENSMUSG00000028369.15 Svep1 4 0 High Q8CG48 Structural maintenance of chromosomes protein 2 OS=Mus musculus OX=10090 GN=Smc2 PE=1 SV=2 0 4.31 2 1 1 1 1191 134.2 8.41 1 1 cell division;cell organization and biogenesis;metabolic process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding "Pf01576, Pf02463, Pf04111, Pf05911, Pf06470, Pf09321, Pf09726, Pf12128, Pf13166, Pf13175, Pf13304, Pf13476, Pf13555, Pf14362" 14211 ENSMUSG00000028312.19 Smc2 4 Condensation of Prometaphase Chromosomes; Condensation of Prophase Chromosomes 0 High O88967 ATP-dependent zinc metalloprotease YME1L1 OS=Mus musculus OX=10090 GN=Yme1l1 PE=1 SV=1 0 4.676 2 1 1 1 715 80 8.97 1 1 183294.3906 360692.0625 1 1 cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf00004, Pf01078, Pf01434, Pf05496, Pf06068, Pf07724, Pf07728, Pf13191, Pf13207, Pf13401, Pf13481" 27377 ENSMUSG00000026775.9 Yme1l1 2 Processing of SMDT1 0 High Q3V3R4 Integrin alpha-1 OS=Mus musculus OX=10090 GN=Itga1 PE=1 SV=2 0 3.421 1 1 1 1 1179 130.7 6.2 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cell surface;membrane metal ion binding;protein binding "Pf00092, Pf01839, Pf08441, Pf13517, Pf13519, Pf14312" 109700 ENSMUSG00000042284.9 Itga1 13 Smooth Muscle Contraction; Integrin cell surface interactions Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Dilated cardiomyopathy; ECM-receptor interaction; PI3K-Akt signaling pathway; Hematopoietic cell lineage 0 High Q4LFA9 Semaphorin-3G OS=Mus musculus OX=10090 GN=Sema3g PE=2 SV=1 0 2.238 1 1 1 1 780 86.6 8.56 1 1 590950.375 1 regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf01403, Pf01437" 218877 ENSMUSG00000021904.5 Sema3g 14 Axon guidance 0 High P50172 Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Mus musculus OX=10090 GN=Hsd11b1 PE=1 SV=3 0 4.205 4 1 1 1 292 32.3 8.46 1 1 643125.25 1 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane catalytic activity;nucleotide binding "Pf00106, Pf08643, Pf08659, Pf13460, Pf13561" 15483 ENSMUSG00000016194.14 Hsd11b1 1 Glucocorticoid biosynthesis Steroid hormone biosynthesis; Metabolic pathways; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 Low A0A0R4J212 Enhancer of filamentation 1 OS=Mus musculus OX=10090 GN=Nedd9 PE=1 SV=1 0.051 1.008 3 1 1 1 833 93 6.58 1 1 cell division;regulation of biological process cytoplasm;cytoskeleton;cytosol;membrane;nucleus protein binding "Pf00018, Pf07653, Pf08824, Pf12026, Pf14604" 18003 ENSMUSG00000021365.14 Nedd9 13 0 High Q8K4Z3 NAD(P)H-hydrate epimerase OS=Mus musculus OX=10090 GN=Naxe PE=1 SV=1 0 4.264 4 1 1 1 282 31 7.69 1 1 1364347.5 1 cell organization and biogenesis;metabolic process cytosol;extracellular;mitochondrion;nucleus catalytic activity;metal ion binding;nucleotide binding;protein binding Pf03853 246703 ENSMUSG00000028070.7 Apoa1bp; Naxe 3 Nicotinamide salvaging 0 Medium Q8BTU1 Cilia- and flagella-associated protein 20 OS=Mus musculus OX=10090 GN=Cfap20 PE=1 SV=1 0.032 1.267 6 1 1 1 193 22.7 9.76 1 1 1025562.25 2239717.5 2337626.75 2088547.25 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytoskeleton;nucleus RNA binding Pf05018 14894 ENSMUSG00000031796.7 Gtl3; Cfap20 8 0 High Q99N87 "28S ribosomal protein S5, mitochondrial OS=Mus musculus OX=10090 GN=Mrps5 PE=1 SV=1" 0 3.215 3 1 1 1 432 48.2 10.14 1 1 278711.5625 306088.375 551984.25 1 1 1 metabolic process mitochondrion;ribosome RNA binding;structural molecule activity Pf03719 77721 ENSMUSG00000027374.12 Mrps5 2 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High Q9CW79 Golgin subfamily A member 1 OS=Mus musculus OX=10090 GN=Golga1 PE=1 SV=2 0.01 1.906 3 1 1 1 758 87.3 5.52 1 1 transport Golgi;membrane protein binding "Pf01465, Pf07888, Pf12128, Pf13166" 76899 ENSMUSG00000026754.16 Golga1 2 Retrograde transport at the Trans-Golgi-Network 0 Medium Q9CPX7 "28S ribosomal protein S16, mitochondrial OS=Mus musculus OX=10090 GN=Mrps16 PE=1 SV=1" 0.034 1.191 6 1 1 1 135 15.2 9.67 1 1 377812.625 219260.375 770028.875 1 1 1 cell organization and biogenesis;metabolic process cytosol;mitochondrion;ribosome structural molecule activity Pf00886 66242 ENSMUSG00000049960.3 Mrps16 14 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Medium Q3UVV9 von Willebrand factor A domain-containing protein 3A OS=Mus musculus OX=10090 GN=Vwa3a PE=2 SV=1 0.042 1.085 1 1 1 1 1148 130 8.38 1 1 281287.2813 280570.2188 816151 1 1 1 "Pf00092, Pf13519, Pf13768" 233813 ENSMUSG00000030889.14 Vwa3a 7 0 Medium P10493 Nidogen-1 OS=Mus musculus OX=10090 GN=Nid1 PE=1 SV=2 0.032 1.245 1 1 1 1 1245 136.5 5.44 1 1 180288.9063 531080 528053.875 224804.7344 1 1 1 1 cell organization and biogenesis;regulation of biological process cell surface;extracellular;membrane metal ion binding;protein binding "Pf00008, Pf00058, Pf00086, Pf06119, Pf06247, Pf07474, Pf07645, Pf12662, Pf12947, Pf14670" 18073 ENSMUSG00000005397.7 Nid1 13 Laminin interactions; Degradation of the extracellular matrix 0 High Q99N32 Beta-klotho OS=Mus musculus OX=10090 GN=Klb PE=1 SV=1 0 4.421 1 1 1 1 1043 120.1 9.04 1 1 214822.1719 1 metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;protein binding Pf00232 83379 ENSMUSG00000029195.10 Klb 5 "PI3K Cascade; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; betaKlotho-mediated ligand binding; Phospholipase C-mediated cascade; FGFR4; FRS-mediated FGFR3 signaling; Interleukin-20 family signaling; FRS-mediated FGFR2 signaling; Negative regulation of FGFR4 signaling; RAF/MAP kinase cascade; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR4; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4" 0 High P23780 Beta-galactosidase OS=Mus musculus OX=10090 GN=Glb1 PE=1 SV=1 0 4.165 2 1 1 1 647 73.1 7.47 1 1 80159.64844 263556.9688 501760.2813 1 1 1 metabolic process;response to stimulus cytoplasm;Golgi;vacuole catalytic activity "Pf01301, Pf02449, Pf13364" 12091 ENSMUSG00000045594.10 Glb1 9 HS-GAG degradation; Sialic acid metabolism; Neutrophil degranulation; Keratan sulfate degradation; Glycosphingolipid metabolism Metabolic pathways; Lysosome; Sphingolipid metabolism; Glycosphingolipid biosynthesis - ganglio series; Glycosaminoglycan degradation; Other glycan degradation; Galactose metabolism 0 Medium Q9Z1R3 Apolipoprotein M OS=Mus musculus OX=10090 GN=Apom PE=1 SV=1 0.023 1.452 3 1 1 1 190 21.3 6.52 1 1 68299.73438 167817.7969 200720.5938 180423.5781 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport extracellular antioxidant activity;catalytic activity;protein binding;transporter activity Pf11032 55938 ENSMUSG00000024391.7 Apom 17 Signaling by GPCR; Retinoid metabolism and transport 0 High Q921Q3 Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Mus musculus OX=10090 GN=Alg1 PE=1 SV=3 0 4.673 3 1 1 1 482 54.4 8.37 1 1 168504.5625 214768.875 600497.1875 1 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity "Pf00534, Pf13524, Pf13692" 208211 ENSMUSG00000039427.14 Alg1 16 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" Metabolic pathways; N-Glycan biosynthesis 0 High P54276 DNA mismatch repair protein Msh6 OS=Mus musculus OX=10090 GN=Msh6 PE=1 SV=3 0 2.556 1 1 1 1 1358 151 6.73 1 1 105243.6719 338422.3438 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytosol;Golgi;nucleus catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" 17688 ENSMUSG00000005370.3 Msh6 17 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Platinum drug resistance; Pathways in cancer; Colorectal cancer; Mismatch repair 0 Medium Q9DCF9 Translocon-associated protein subunit gamma OS=Mus musculus OX=10090 GN=Ssr3 PE=1 SV=1 0.045 1.077 3 1 1 1 185 21.1 9.61 1 1 66824.60156 66928.55469 450618.6563 1 1 1 cell organization and biogenesis;transport endoplasmic reticulum;membrane Pf07074 67437 ENSMUSG00000027828.12 Ssr3 3 Protein processing in endoplasmic reticulum 0 High Q80UW8 "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Mus musculus OX=10090 GN=Polr2e PE=1 SV=1" 0 5.05 7 1 1 1 210 24.6 5.95 1 1 metabolic process nucleus catalytic activity;DNA binding "Pf01191, Pf03871" 66420 ENSMUSG00000004667.18 Polr2e 10 mRNA Capping; RNA Polymerase II Transcription Initiation; Transcriptional regulation by small RNAs; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Termination; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; RNA Pol II CTD phosphorylation and interaction with CE; FGFR2 alternative splicing; RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; RNA Polymerase III Transcription Initiation From Type 1 Promoter; Dual incision in TC-NER; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA polymerase II transcribes snRNA genes; Formation of the Early Elongation Complex; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase I Promoter Escape; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Purine metabolism; Huntington's disease; Pyrimidine metabolism; Cytosolic DNA-sensing pathway 0 Medium Q8VCF1 Soluble calcium-activated nucleotidase 1 OS=Mus musculus OX=10090 GN=Cant1 PE=2 SV=1 0.018 1.619 2 1 1 1 403 45.6 6.77 1 1 391773.4688 1 metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;Golgi;membrane catalytic activity;metal ion binding;protein binding;signal transducer activity Pf06079 76025 ENSMUSG00000025575.14 Cant1 11 Neutrophil degranulation Purine metabolism; Pyrimidine metabolism 0 High Q8K2T4 Ubiquinol-cytochrome-c reductase complex assembly factor 3 OS=Mus musculus OX=10090 GN=Uqcc3 PE=1 SV=1 0 2.457 11 1 1 1 89 9.6 9.52 1 1 126164.0625 1648570 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion catalytic activity Pf15141 107197 ENSMUSG00000071654.5 AI462493; Uqcc3 19 0 Medium Q8C7V3 U3 small nucleolar RNA-associated protein 15 homolog OS=Mus musculus OX=10090 GN=Utp15 PE=1 SV=1 0.027 1.33 5 1 1 1 528 59.3 8.79 1 1 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;nucleus protein binding;RNA binding "Pf00400, Pf09384" 105372 ENSMUSG00000041747.2 Utp15 13 Major pathway of rRNA processing in the nucleolus and cytosol Ribosome biogenesis in eukaryotes 0 Medium A2AIL4 "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Mus musculus OX=10090 GN=Ndufaf6 PE=1 SV=1" 0.043 1.081 4 1 1 1 333 38.3 9.44 1 1 cell organization and biogenesis;metabolic process cytoplasm;membrane;mitochondrion;nucleus catalytic activity Pf00494 76947 ENSMUSG00000050323.14 Ndufaf6 4 Complex I biogenesis 0 Medium Q3TMX7 Sulfhydryl oxidase 2 OS=Mus musculus OX=10090 GN=Qsox2 PE=1 SV=1 0.027 1.403 1 1 1 1 692 77.7 8.59 1 1 47297.17188 60203.01563 299000.2188 1 1 1 cellular homeostasis;metabolic process;regulation of biological process Golgi;membrane catalytic activity "Pf00085, Pf04777" 227638 Qsox2 2 0 High E9PUY1 "28S ribosomal protein S12, mitochondrial (Fragment) OS=Mus musculus OX=10090 GN=Mrps12 PE=1 SV=1" 0 2.456 20 1 1 1 125 13.9 10.43 1 1 143796.9531 304950.125 225404.4688 471271.3125 1 1 1 1 metabolic process ribosome structural molecule activity Pf00164 ENSMUSG00000045948.8 7 0 High O35683 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 OS=Mus musculus OX=10090 GN=Ndufa1 PE=1 SV=1 0 3.366 14 1 1 1 70 8.1 9.48 1 1 1424897.125 1 cell organization and biogenesis;metabolic process;transport cytosol;membrane;mitochondrion 54405 ENSMUSG00000016427.7 Ndufa1 X Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q80UM7 Mannosyl-oligosaccharide glucosidase OS=Mus musculus OX=10090 GN=Mogs PE=1 SV=1 0 2.648 2 1 1 1 834 91.8 9 1 1 459224.7813 1 metabolic process endoplasmic reticulum;membrane catalytic activity Pf03200 57377 ENSMUSG00000030036.8 Mogs 6 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 Medium A0A286YDB7 Translocon-associated protein subunit alpha (Fragment) OS=Mus musculus OX=10090 GN=Ssr1 PE=1 SV=1 0.016 1.642 7 1 1 1 115 13.1 3.81 1 1 381664.5625 432328.7188 2008946.875 1 1 1 0 Medium V9GX81 Maestro heat-like repeat family member 6 OS=Mus musculus OX=10090 GN=Mroh6 PE=1 SV=1 0.012 1.814 1 1 1 1 722 78.4 8.76 1 1 602989.875 1099608.875 861628.25 1 1 1 transport transporter activity 223645 ENSMUSG00000098678.1 Gm19570; Mroh6 15 0 Medium Q5SSH7 Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Mus musculus OX=10090 GN=Zzef1 PE=1 SV=2 0.034 1.153 1 1 1 1 2924 328.1 6.11 1 1 metal ion binding "Pf00569, Pf03256" 195018 Zzef1 11 0 High Q91V77 Protein S100 OS=Mus musculus OX=10090 GN=S100a1 PE=1 SV=1 0 7.127 23 1 1 1 94 10.5 4.59 1 1 391078.4375 1 Met-loss+Acetyl [N-Term] regulation of biological process cytoplasm;endoplasmic reticulum;nucleus metal ion binding;protein binding Pf01023 20193 ENSMUSG00000044080.9 S100a1 3 Regulation of TLR by endogenous ligand 0 High D6RCX5 Mitochondrial fission regulator 1-like OS=Mus musculus OX=10090 GN=Mtfr1l PE=1 SV=1 0 3.8 6 1 1 1 202 22.4 10.51 1 1 444158.6875 1 Pf05308 ENSMUSG00000046671.18 4 0 Medium Q9Z0H3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Mus musculus OX=10090 GN=Smarcb1 PE=1 SV=1 0.022 1.467 2 1 1 1 385 44.1 6.23 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf04855 20587 ENSMUSG00000000902.13 Smarcb1 10 RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 0 High P62075 Mitochondrial import inner membrane translocase subunit Tim13 OS=Mus musculus OX=10090 GN=Timm13 PE=1 SV=1 0 3.754 12 1 1 1 95 10.5 8.18 1 1 257828.5469 700002 1 1 cell organization and biogenesis;transport membrane;mitochondrion metal ion binding;transporter activity Pf02953 30055 ENSMUSG00000020219.7 Timm13 10 0 Medium G3UXL2 Phosphoribosyl pyrophosphate synthetase 1-like 3 OS=Mus musculus OX=10090 GN=Prps1l3 PE=3 SV=1 0.027 1.387 3 1 1 1 318 34.8 6.98 1 1 191282.6563 185977.0938 349520.7188 1 1 1 metabolic process catalytic activity;metal ion binding "Pf00156, Pf13793, Pf14572" 328099 ENSMUSG00000079104.4 Prps1l3 12 Metabolic pathways; Biosynthesis of amino acids; Purine metabolism; Pentose phosphate pathway; Carbon metabolism 0 Medium O54782 Epididymis-specific alpha-mannosidase OS=Mus musculus OX=10090 GN=Man2b2 PE=1 SV=2 0.032 1.226 1 1 1 1 1018 115.5 7.39 1 1 67127.07031 97823.91406 260813.7188 1 1 1 metabolic process extracellular;vacuole catalytic activity;metal ion binding "Pf01074, Pf07748, Pf09261" 17160 ENSMUSG00000029119.9 Man2b2 5 Lysosomal oligosaccharide catabolism Other glycan degradation 0 Medium E9QPI5 Sister chromatid cohesion protein PDS5 homolog A OS=Mus musculus OX=10090 GN=Pds5a PE=1 SV=1 0.022 1.474 1 1 1 1 1332 150.1 7.85 1 1 176821.6563 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;membrane;nucleus 71521 ENSMUSG00000029202.12 Pds5a 5 Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids 0 Medium Q3UHC0 Trinucleotide repeat-containing gene 6C protein OS=Mus musculus OX=10090 GN=Tnrc6c PE=1 SV=2 0.014 1.758 1 1 1 1 1690 175.7 6.86 1 1 602295.0625 514192.4688 662420.125 1 1 1 regulation of biological process protein binding;RNA binding "Pf00076, Pf00627, Pf10427, Pf12938, Pf13893, Pf14259" 217351 Tnrc6c 11 0 High Q9CQ06 "39S ribosomal protein L24, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl24 PE=1 SV=1" 0.008 1.969 3 1 1 1 216 24.9 9.5 1 1 135158.25 99425.41406 245180.25 1 1 1 metabolic process mitochondrion;ribosome structural molecule activity 67707 ENSMUSG00000019710.13 Mrpl24 3 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 Low Q91Y74 "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 OS=Mus musculus OX=10090 GN=St3gal4 PE=1 SV=1" 0.057 0.926 4 1 1 1 333 38 9.36 1 1 metabolic process Golgi;membrane catalytic activity Pf00777 20443 ENSMUSG00000032038.7 St3gal4 9 Termination of O-glycan biosynthesis; Sialic acid metabolism; N-Glycan antennae elongation; Keratan sulfate biosynthesis Metabolic pathways; Glycosphingolipid biosynthesis - lacto and neolacto series 0 High D3Z5U3 Deoxyribonuclease II alpha (Fragment) OS=Mus musculus OX=10090 GN=Dnase2a PE=1 SV=8 0 2.457 4 1 1 1 181 20.1 8.54 1 1 77353.16406 136488.8125 365106.625 1 1 1 cell differentiation;metabolic process catalytic activity Pf03265 ENSMUSG00000003812.13 8 0 Medium A0A0G2JER6 "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (Fragment) OS=Mus musculus OX=10090 GN=Agap3 PE=1 SV=1" 0.032 1.259 2 1 1 1 445 48.7 8.27 1 1 272087.5625 140041.7656 248421.3438 1 1 1 regulation of biological process enzyme regulator activity;metal ion binding;protein binding "Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857" ENSMUSG00000023353.14 5 0 High D3Z3F1 Pre-mRNA 3'-end-processing factor FIP1 (Fragment) OS=Mus musculus OX=10090 GN=Fip1l1 PE=1 SV=2 0 4.765 4 1 1 1 434 46.4 4.74 1 1 541735.3125 1 Pf05182 ENSMUSG00000029227.15 5 0 High Q99LC8 Translation initiation factor eIF-2B subunit alpha OS=Mus musculus OX=10090 GN=Eif2b1 PE=1 SV=1 0.008 1.95 5 1 1 1 305 33.8 8.32 1 1 802134.0625 1 metabolic process;response to stimulus cytoplasm;membrane nucleotide binding;protein binding;RNA binding Pf01008 209354 ENSMUSG00000029388.14 Eif2b1 5 Recycling of eIF2:GDP RNA transport 0 High Q9DCX2 "ATP synthase subunit d, mitochondrial OS=Mus musculus OX=10090 GN=Atp5pd PE=1 SV=3" 0 2.716 7 1 1 1 161 18.7 5.69 1 1 125452.9063 335162.4688 445096.3438 714886.4375 1 1 1 1 metabolic process;transport cytosol;membrane;mitochondrion catalytic activity;transporter activity Pf05873 71679 ENSMUSG00000034566.10 Atp5h 11 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 Low E9Q0B6 "Dynein, axonemal, heavy chain 6 OS=Mus musculus OX=10090 GN=Dnah6 PE=1 SV=1" 0.058 0.847 0 1 1 1 4144 474.5 5.63 1 1 199719.7031 2988847.25 1 1 cell organization and biogenesis;cellular component movement catalytic activity;motor activity;nucleotide binding;protein binding "Pf03028, Pf07728, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13863" 330355 ENSMUSG00000052861.13 Dnah6; Dnahc6 6 Huntington's disease 0 Medium E1U8D0 Protein SOGA1 OS=Mus musculus OX=10090 GN=Soga1 PE=1 SV=3 0.034 1.163 1 1 1 1 1418 159.1 6.46 1 1 240096.7813 149983.75 154400.4219 153942.75 1 1 1 1 metabolic process;regulation of biological process;response to stimulus extracellular protein binding "Pf02463, Pf04111, Pf11365, Pf14818" 320706 9830001H06Rik; Soga1 2 0 High Q9Z1E4 "Glycogen [starch] synthase, muscle OS=Mus musculus OX=10090 GN=Gys1 PE=1 SV=2" 0 3.291 1 1 1 1 738 83.9 6.11 1 1 266445.5 361720.1875 297156.4688 600316 1 1 1 1 metabolic process cytoplasm;membrane catalytic activity;protein binding "Pf00534, Pf05693, Pf13579" 14936 ENSMUSG00000003865.16 Gys1 7 Glycogen synthesis Insulin signaling pathway; Metabolic pathways; Insulin resistance; Starch and sucrose metabolism; PI3K-Akt signaling pathway; AMPK signaling pathway; Glucagon signaling pathway 0 Medium Q62193 Replication protein A 32 kDa subunit OS=Mus musculus OX=10090 GN=Rpa2 PE=1 SV=1 0.032 1.242 5 1 1 1 270 29.7 6.15 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus DNA binding;protein binding Pf08784 19891 Rpa2 4 Meiotic Recombination; Mus musculus biological processes 0 Low A0A3Q4EGR2 Rho-associated protein kinase 1 OS=Mus musculus OX=10090 GN=Rock1 PE=1 SV=1 0.051 1.001 1 1 1 1 1089 127.5 5.31 1 1 882555.3125 1 0 High Q8BXL7 ADP-ribosylation factor-related protein 1 OS=Mus musculus OX=10090 GN=Arfrp1 PE=1 SV=2 0.01 1.91 5 1 1 1 201 22.6 6.55 1 1 105063.5547 1 Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;Golgi;membrane catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439" 76688 ENSMUSG00000038671.15 Arfrp1 2 Retrograde transport at the Trans-Golgi-Network 0 Medium A2BDX3 Adenylyltransferase and sulfurtransferase MOCS3 OS=Mus musculus OX=10090 GN=Mocs3 PE=1 SV=1 0.035 1.147 2 1 1 1 460 49.3 7.49 1 1 160528.1094 642904.5 752628.9375 702464.375 1 1 1 1 metabolic process cytoplasm;cytosol catalytic activity;metal ion binding;nucleotide binding "Pf00581, Pf00899, Pf05237" 69372 ENSMUSG00000074576.4 Mocs3 2 Molybdenum cofactor biosynthesis Sulfur relay system 0 High Q80SW1 S-adenosylhomocysteine hydrolase-like protein 1 OS=Mus musculus OX=10090 GN=Ahcyl1 PE=1 SV=1 0.008 1.98 2 1 1 1 530 58.9 6.89 1 1 300501.375 1 metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endoplasmic reticulum;membrane catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00670, Pf01262, Pf01488, Pf02254, Pf02826, Pf05221" 229709 ENSMUSG00000027893.14 Ahcyl1 3 Ion homeostasis Metabolic pathways; Cysteine and methionine metabolism 0 High B1ATE0 N-sulfoglucosamine sulfohydrolase (sulfamidase) OS=Mus musculus OX=10090 GN=Sgsh PE=1 SV=1 0 4.724 3 1 1 1 422 46.3 7.66 1 1 1569568.375 1 metabolic process vacuole catalytic activity;protein binding "Pf00884, Pf01663" 27029 ENSMUSG00000005043.13 Sgsh 11 HS-GAG degradation 0 Medium D3Z0L6 Glycerol-3-phosphate dehydrogenase 1-like protein OS=Mus musculus OX=10090 GN=Gpd1l PE=1 SV=1 0.014 1.712 10 1 1 1 117 13.1 8.07 1 1 1001348.938 1 metabolic process membrane catalytic activity Pf07479 ENSMUSG00000050627.13 9 0 High A0A0R4J291 "FAST kinase domain-containing protein 5, mitochondrial OS=Mus musculus OX=10090 GN=Fastkd5 PE=4 SV=1" 0 5.093 2 1 1 1 807 91.6 8.65 1 1 514790.5313 1 cell organization and biogenesis;metabolic process;transport mitochondrion catalytic activity;RNA binding Pf05159 380601 ENSMUSG00000079043.2 Fastkd5 2 0 Medium Q9CRB9 MICOS complex subunit Mic19 OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 0.018 1.618 11 1 1 1 227 26.3 8.37 1 1 251092.4688 389436.9375 1 1 cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion;nucleus protein binding;structural molecule activity "Pf05300, Pf06747" 66075 ENSMUSG00000053768.13 Chchd3 6 0 Medium F8WJG3 Transformer-2 protein homolog beta OS=Mus musculus OX=10090 GN=Tra2b PE=1 SV=1 0.027 1.336 5 1 1 1 188 21.9 10.15 1 1 677611.8125 1544479.875 990613.4375 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus membrane;nucleus;spliceosomal complex protein binding;RNA binding "Pf00076, Pf08777, Pf13893, Pf14259" 20462 ENSMUSG00000022858.15 Tra2b 16 0 High Q9D1M0 Protein SEC13 homolog OS=Mus musculus OX=10090 GN=Sec13 PE=1 SV=3 0 4.759 3 1 1 1 322 35.5 5.38 1 1 83641.14063 202899.0313 291222.4375 498568.7813 1 1 1 1 cell organization and biogenesis;regulation of biological process;transport chromosome;cytosol;endoplasmic reticulum;membrane;nucleus;vacuole protein binding Pf00400 110379 ENSMUSG00000030298.10 Sec13 6 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; RHO GTPases Activate Formins; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; COPII (Coat Protein 2) Mediated Vesicle Transport" mTOR signaling pathway; RNA transport; Protein processing in endoplasmic reticulum 0 Medium Q9CQB2 MAPK regulated corepressor interacting protein 2 OS=Mus musculus OX=10090 GN=Mcrip2 PE=1 SV=1 0.022 1.482 16 1 1 1 160 17.9 7.3 1 1 cytoplasm;nucleus protein binding Pf14799 68241 ENSMUSG00000025732.5 Fam195a; Mcrip2 17 0 Medium A3KGW4 Inactive glycosyltransferase 25 family member 3 (Fragment) OS=Mus musculus OX=10090 GN=Cercam PE=4 SV=8 0.028 1.29 15 1 1 1 91 10.8 9.5 1 1 930081.3125 1018174 1 1 ENSMUSG00000039787.13 2 0 Medium P50543 Protein S100-A11 OS=Mus musculus OX=10090 GN=S100a11 PE=1 SV=1 0.014 1.761 10 1 1 1 98 11.1 5.45 1 1 5343164 6029623 5149328 6544158 1 1 1 1 regulation of biological process cytoplasm;extracellular;nucleus metal ion binding;protein binding "Pf00036, Pf01023, Pf13499, Pf13833" 20195 ENSMUSG00000027907.4 S100a11 3 Neutrophil degranulation 0 Medium E9PWE9 Tyrosine-protein kinase OS=Mus musculus OX=10090 GN=Syk PE=1 SV=1 0.032 1.235 2 1 1 1 583 66 7.15 1 1 defense response;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00017, Pf00069, Pf07714" ENSMUSG00000021457.14 13 0 Medium A0A0G2JGL8 ATP-dependent RNA helicase DHX30 OS=Mus musculus OX=10090 GN=Dhx30 PE=1 SV=1 0.027 1.401 1 1 1 1 1186 132.9 8.59 1 1 410843.3125 259776.0313 278348.4375 1 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;mitochondrion catalytic activity;nucleotide binding;RNA binding "Pf00270, Pf00271, Pf04408, Pf07717" 72831 ENSMUSG00000032480.17 Dhx30 9 0 Medium B2RSU6 Cingulin-like 1 OS=Mus musculus OX=10090 GN=Cgnl1 PE=1 SV=1 0.047 1.061 1 1 1 1 1297 148.1 5.77 1 1 569384.875 661330.125 598655.8125 451627.5938 1 1 1 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport cytoplasm;cytoskeleton;Golgi catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity "Pf00038, Pf00261, Pf00769, Pf01496, Pf01576, Pf02463, Pf03961, Pf03962, Pf04094, Pf04111, Pf04156, Pf05262, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06008, Pf06160, Pf06548, Pf06785, Pf06810, Pf07111, Pf07888, Pf07946, Pf09726, Pf09730, Pf10174, Pf12128, Pf13166, Pf13514, Pf13654, Pf13851, Pf13863, Pf13868, Pf15070, Pf15450, Pf15619" 68178 ENSMUSG00000032232.14 Cgnl1 9 0 Medium D3Z4C9 Ubiquinol-cytochrome-c reductase complex assembly factor 2 OS=Mus musculus OX=10090 GN=Uqcc2 PE=1 SV=1 0.04 1.112 6 1 1 1 127 15.4 9.7 1 1 948137.625 1 regulation of biological process membrane;mitochondrion;organelle lumen ENSMUSG00000024208.15 17 0 High A0A1W2P7J1 Coenzyme Q10A OS=Mus musculus OX=10090 GN=Coq10a PE=1 SV=1 0 2.43 4 1 1 1 249 27.9 9.99 1 1 93952.39844 1461637.25 1 1 metabolic process mitochondrion Pf03364 210582 ENSMUSG00000039914.6 Coq10a 10 0 Medium E9PU93 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Mus musculus OX=10090 GN=Ash2l PE=1 SV=1 0.014 1.783 2 1 1 1 534 60.1 6.95 1 1 512707.9375 863439.625 798266.3125 763636.625 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;metal ion binding;protein binding Pf00622 23808 ENSMUSG00000031575.18 Ash2l 8 0 High A0A2I3BPH8 5'-nucleotidase domain-containing 2 (Fragment) OS=Mus musculus OX=10090 GN=Nt5dc2 PE=1 SV=1 0 3.85 5 1 1 1 281 31.8 5.1 1 1 475403.5938 1 0 High Q9EP52 Twisted gastrulation protein homolog 1 OS=Mus musculus OX=10090 GN=Twsg1 PE=1 SV=1 0 3.599 7 1 1 1 222 24.8 5.5 1 1 cell differentiation;development;regulation of biological process;response to stimulus extracellular protein binding Pf04668 65960 ENSMUSG00000024098.5 Twsg1 17 0 High Q9QY76 Vesicle-associated membrane protein-associated protein B OS=Mus musculus OX=10090 GN=Vapb PE=1 SV=3 0.004 2.139 6 1 1 1 243 26.9 7.78 1 1 534059.1875 1 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;Golgi;membrane protein binding Pf00635 56491 Vapb 2 0 Medium Q9D952 Envoplakin OS=Mus musculus OX=10090 GN=Evpl PE=1 SV=3 0.048 1.029 1 1 1 1 2035 231.9 6.6 1 1 1776032.125 1549961.625 2279314.25 1423319.625 1 1 1 1 cell differentiation;metabolic process cytoplasm;cytoskeleton;cytosol protein binding;structural molecule activity Pf00681 14027 ENSMUSG00000034282.3 Evpl 11 Formation of the cornified envelope 0 Medium P52503 "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Mus musculus OX=10090 GN=Ndufs6 PE=1 SV=2" 0.047 1.057 10 1 1 1 116 13 8.65 1 1 896068 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion Pf10276 407785 ENSMUSG00000021606.7 Ndufs6 13 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High A0A3Q4EH93 Cytosolic Fe-S cluster assembly factor NUBP2 OS=Mus musculus OX=10090 GN=Nubp2 PE=1 SV=1 0 4.518 6 1 1 1 211 23 5.81 1 1 1149432.625 1 0 Medium Q4FE56 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus OX=10090 GN=Usp9x PE=1 SV=1 0.04 1.1 0 1 1 1 2554 290 5.83 1 1 cell division;cell growth;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane catalytic activity;protein binding "Pf00443, Pf13423" 22284 ENSMUSG00000031010.17 Usp9x X Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0 High E9PW03 Glycosylphosphatidylinositol anchor attachment 1 protein OS=Mus musculus OX=10090 GN=Gpaa1 PE=1 SV=1 0 2.594 2 1 1 1 561 61.4 8.1 1 1 537206.4375 1 membrane Pf04114 ENSMUSG00000022561.12 15 0 High H3BIX0 Treacle protein (Fragment) OS=Mus musculus OX=10090 GN=Tcof1 PE=1 SV=1 0.01 1.918 2 1 1 1 1056 107 6.95 1 1 protein binding Pf03546 ENSMUSG00000024613.16 18 0 Medium G5E880 Lymphoid-restricted membrane protein OS=Mus musculus OX=10090 GN=Lrmp PE=1 SV=1 0.016 1.66 3 1 1 1 539 59.4 5.08 1 1 5354239 6695381.5 61992348 1 1 1 chromosome;cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;nucleus protein binding Pf05781 16970 ENSMUSG00000030263.13 Lrmp 6 Neutrophil degranulation 0 High Q9JJW6 Aly/REF export factor 2 OS=Mus musculus OX=10090 GN=Alyref2 PE=1 SV=1 0 3.353 5 1 1 1 218 23.7 10.04 1 1 691909.625 394411.5313 242417.25 1 1 1 metabolic process;transport cytoplasm;nucleus;spliceosomal complex DNA binding;RNA binding "Pf00076, Pf13893, Pf14259" 56009 Alyref2 1 mRNA surveillance pathway; Herpes simplex infection; Spliceosome; RNA transport 0 High E9Q1C5 "Interferon, alpha-inducible protein 27 OS=Mus musculus OX=10090 GN=Ifi27 PE=4 SV=1" 0 2.761 3 1 1 1 250 24.7 8.09 1 1 80911.5625 234400.8125 1 1 regulation of biological process membrane protein binding Pf06140 52668 ENSMUSG00000064215.13 Ifi27; Ifi27l1 12 0 High D6RHR9 DnaJ homolog subfamily B member 12 OS=Mus musculus OX=10090 GN=Dnajb12 PE=1 SV=1 0 3.677 24 1 1 1 126 13.8 8.47 1 1 248886.5938 872777.6875 1 1 protein binding ENSMUSG00000020109.13 10 0 High Q9D7H3 RNA 3'-terminal phosphate cyclase OS=Mus musculus OX=10090 GN=RtcA PE=1 SV=2 0 3.065 3 1 1 1 366 39.2 7.9 1 1 1168068.625 1 metabolic process nucleus catalytic activity;nucleotide binding;RNA binding "Pf01137, Pf05189" 66368 ENSMUSG00000000339.14 Rtca; Rtcd1 3 0 Medium Q9CWD8 Iron-sulfur protein NUBPL OS=Mus musculus OX=10090 GN=Nubpl PE=1 SV=2 0.014 1.747 3 1 1 1 319 34.1 9.07 1 1 340583.2813 1 cell organization and biogenesis membrane;mitochondrion metal ion binding;nucleotide binding "Pf01656, Pf10609" 76826 ENSMUSG00000035142.18 Nubpl 12 Complex I biogenesis 0 High F8WH41 Striatin OS=Mus musculus OX=10090 GN=Strn PE=1 SV=1 0 5.158 3 1 1 1 627 69.1 5.19 1 1 53473.85547 181770.8906 193003.3125 253653.2969 1 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cytoplasm;membrane protein binding "Pf00400, Pf08232" 268980 ENSMUSG00000024077.15 Strn 17 0 Medium E0CYU9 Protein ZNRD2 OS=Mus musculus OX=10090 GN=Znrd2 PE=1 SV=1 0.014 1.752 9 1 1 1 88 10.1 9.1 1 1 563925.75 356260.0313 1 1 Pf06677 ENSMUSG00000079478.8 19 0 High A0A0R4J1Q0 Enhancer of mRNA-decapping protein 4 OS=Mus musculus OX=10090 GN=Edc4 PE=1 SV=1 0 2.451 1 1 1 1 1390 150.6 5.68 1 1 metabolic process cytoplasm;membrane;nucleus protein binding Pf00400 234699 ENSMUSG00000036270.16 Edc4 8 mRNA decay by 5' to 3' exoribonuclease 0 Low P28660 Nck-associated protein 1 OS=Mus musculus OX=10090 GN=Nckap1 PE=1 SV=2 0.057 0.932 1 1 1 1 1128 128.7 6.62 1 1 4885791.5 4097903.5 4570824 1 1 1 cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus cytoplasm;membrane protein binding Pf09735 50884 ENSMUSG00000027002.13 Nckap1 2 RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation Regulation of actin cytoskeleton 0 High Q6P8I6 "Cytochrome c oxidase assembly protein COX11, mitochondrial OS=Mus musculus OX=10090 GN=Cox11 PE=1 SV=1" 0.008 1.971 9 1 1 1 275 30.8 8.78 1 1 111787.5781 68179.54688 333106.1563 1 1 1 regulation of biological process membrane;mitochondrion metal ion binding;protein binding Pf04442 69802 ENSMUSG00000020544.14 Cox11 11 Metabolic pathways; Oxidative phosphorylation 0 Medium Q99ML4 Divergent protein kinase domain 1B OS=Mus musculus OX=10090 GN=Dipk1b PE=1 SV=1 0.023 1.439 2 1 1 1 431 48.8 8.15 1 1 719023.5 1 endoplasmic reticulum;membrane "Pf12260, Pf14875" 56279 ENSMUSG00000036186.5 Fam69b 2 0 High Q3V2Y9 Dual-specificity protein phosphatase 3 OS=Mus musculus OX=10090 GN=Dusp3 PE=1 SV=1 0 3.293 10 1 1 1 117 13.2 8.46 1 1 64486.49609 161421.8438 1017342.438 1 1 1 metabolic process;regulation of biological process cytosol;nucleus catalytic activity;protein binding "Pf00102, Pf00782" 72349 ENSMUSG00000003518.13 Dusp3 11 0 Medium A0A0R4J138 Arylsulfatase B OS=Mus musculus OX=10090 GN=Arsb PE=1 SV=1 0.014 1.694 1 1 1 1 534 59.7 7.14 1 1 82384.71875 626831.3125 1 1 cellular component movement;metabolic process;regulation of biological process;response to stimulus cell surface;endoplasmic reticulum;Golgi;mitochondrion;vacuole catalytic activity;metal ion binding Pf00884 11881 ENSMUSG00000042082.6 Arsb 13 CS/DS degradation; Neutrophil degranulation; Glycosphingolipid metabolism; The activation of arylsulfatases Metabolic pathways; Lysosome; Glycosaminoglycan degradation 0 Medium A0A0G2JE03 Anaphase-promoting complex subunit 5 OS=Mus musculus OX=10090 GN=Anapc5 PE=1 SV=1 0.034 1.192 1 1 1 1 719 80.8 6.77 1 1 248213.9688 1 cell division;metabolic process nucleus protein binding Pf12862 59008 ENSMUSG00000029472.13 Anapc5 5 0 Low D6RGU1 Nucleolysin TIAR OS=Mus musculus OX=10090 GN=Tial1 PE=1 SV=1 0.053 0.99 6 1 1 1 135 15 6.07 1 1 1183084.375 1438447 1176800.5 1031273.063 1 1 1 1 cell division;regulation of biological process cytoplasm;nucleus RNA binding "Pf00076, Pf13893, Pf14259" ENSMUSG00000030846.15 7 0 Medium E9PWX9 Transmembrane protease serine 5 OS=Mus musculus OX=10090 GN=Tmprss5 PE=1 SV=1 0.047 1.051 3 1 1 1 381 41.7 7.5 1 1 395099.8438 287769.7813 618045.8125 1 1 1 metabolic process;transport membrane catalytic activity;receptor activity "Pf00089, Pf09342, Pf15494" ENSMUSG00000032268.13 9 0 Medium Q80XL3 Rrh protein OS=Mus musculus OX=10090 GN=Rrh PE=2 SV=1 0.027 1.331 6 1 1 1 379 41.8 8.65 1 1 4114880.5 1 metabolic process;regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity Pf00001 20132 ENSMUSG00000028012.15 Rrh 3 0 High Q6NT99 Dual specificity protein phosphatase 23 OS=Mus musculus OX=10090 GN=Dusp23 PE=1 SV=1 0.007 2.054 9 1 1 1 150 16.6 8.21 1 1 metabolic process cytoplasm;cytosol;nucleus catalytic activity "Pf00102, Pf00782, Pf14566" 68440 ENSMUSG00000026544.6 Dusp23 1 0 Medium A0A1D5RLZ5 Group XV phospholipase A2 OS=Mus musculus OX=10090 GN=Pla2g15 PE=1 SV=1 0.042 1.095 8 1 1 1 236 26.5 7.97 1 1 metabolic process extracellular;membrane;mitochondrion;vacuole catalytic activity Pf02450 192654 ENSMUSG00000031903.7 Pla2g15 8 0 High G3UX79 "28S ribosomal protein S18b, mitochondrial (Fragment) OS=Mus musculus OX=10090 GN=Mrps18b PE=1 SV=1" 0 2.547 6 1 1 1 188 21.5 7.43 1 1 69143.17188 256633.9688 228955.0781 264429.125 1 1 1 1 metabolic process mitochondrion;ribosome structural molecule activity Pf01084 ENSMUSG00000024436.16 17 0 Medium F6TK14 Fibroblast growth factor receptor OS=Mus musculus OX=10090 GN=Fgfr3 PE=1 SV=1 0.027 1.322 1 1 1 1 801 87.7 6.32 1 1 771023.75 1214165.625 1131186.375 2603035.75 1 1 1 1 cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus;vacuole catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00047, Pf00069, Pf07679, Pf07714, Pf13895, Pf13927" 14184 ENSMUSG00000054252.17 Fgfr3 5 "PI3K Cascade; Phospholipase C-mediated cascade; FGFR3; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; Interleukin-20 family signaling; Negative regulation of FGFR3 signaling; FRS-mediated FGFR2 signaling; RAF/MAP kinase cascade; FRS-mediated FGFR1 signaling; FGFR3c ligand binding and activation; FRS-mediated FGFR4 signaling; FGFR3b ligand binding and activation; PI-3K cascade:FGFR3" 0 Medium Q8BFR1 Zinc finger CCCH-type antiviral protein 1-like OS=Mus musculus OX=10090 GN=Zc3hav1l PE=2 SV=1 0.021 1.545 5 1 1 1 296 32.8 8.44 1 1 338131.9688 896843 643089.5 843975.75 1 1 1 1 cytosol metal ion binding 209032 ENSMUSG00000047749.2 Zc3hav1l 6 0 High Q9EP72 ER membrane protein complex subunit 7 OS=Mus musculus OX=10090 GN=Emc7 PE=1 SV=1 0 5.328 5 1 1 1 241 26.3 9.23 1 1 2225442.5 1 membrane Pf09430 73024 ENSMUSG00000055943.5 Emc7 2 0 High E0CZ34 Proteasome subunit alpha type-3 OS=Mus musculus OX=10090 GN=Psma3 PE=1 SV=1 0 2.288 26 1 1 1 35 3.8 4.91 1 1 309504.0313 279091.4688 340543.75 1 1 1 metabolic process nucleus catalytic activity Pf10584 ENSMUSG00000060073.9 12 0 Medium A0A0G2JDK2 Glucosylceramidase OS=Mus musculus OX=10090 GN=Gba PE=1 SV=1 0.026 1.315 2 1 1 1 388 43.3 8.75 1 1 cell communication;metabolic process;regulation of biological process;response to stimulus membrane;organelle lumen;vacuole catalytic activity;protein binding Pf02055 14466 ENSMUSG00000028048.11 Gba 3 0 High Q61576 Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Mus musculus OX=10090 GN=Fkbp10 PE=1 SV=2 0 2.793 2 1 1 1 581 64.7 5.64 1 1 127607.3281 448094.8438 1 1 cell organization and biogenesis;metabolic process cytoplasm;endoplasmic reticulum;organelle lumen catalytic activity;metal ion binding;protein binding "Pf00254, Pf13499" 14230 ENSMUSG00000001555.10 Fkbp10 11 0 Low Q6KCD5 Nipped-B-like protein OS=Mus musculus OX=10090 GN=Nipbl PE=1 SV=1 0.055 0.968 1 1 1 1 2798 315.3 7.91 1 1 2934220.5 2859502 3084653.75 3776450.75 1 1 1 1 cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus protein binding "Pf03154, Pf05110, Pf10243, Pf11489, Pf12765, Pf12830" 71175 ENSMUSG00000022141.6 Nipbl 15 Cohesin Loading onto Chromatin 0 High Q9D5T0 ATPase family AAA domain-containing protein 1 OS=Mus musculus OX=10090 GN=Atad1 PE=1 SV=1 0.01 1.904 2 1 1 1 361 40.7 6.9 1 1 363997.0625 1 metabolic process;regulation of biological process;response to stimulus membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf05496, Pf06068, Pf07724, Pf07726, Pf13173, Pf13191, Pf13207, Pf13479" 67979 ENSMUSG00000013662.5 Atad1 19 0 Low Q9CVB6 Actin-related protein 2/3 complex subunit 2 OS=Mus musculus OX=10090 GN=Arpc2 PE=1 SV=3 0.057 0.918 2 1 1 1 300 34.3 7.36 1 1 269581.4063 248927.0938 517800.8438 1 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus cell surface;cytoplasm;cytoskeleton;endosome;membrane protein binding;structural molecule activity Pf04045 76709 ENSMUSG00000006304.14 Arpc2 1 RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation Endocytosis; Regulation of actin cytoskeleton; Salmonella infection; Fc gamma R-mediated phagocytosis; Bacterial invasion of epithelial cells 0 Medium Q3UW98 Chloride channel accessory 4B OS=Mus musculus OX=10090 GN=Clca4b PE=1 SV=1 0.035 1.141 3 1 1 1 925 102.1 5.33 1 1 metabolic process;transport membrane catalytic activity;transporter activity "Pf00092, Pf08434, Pf09315, Pf13519, Pf13768" 99709 ENSMUSG00000074195.3 AI747448; Clca4b 3 Stimuli-sensing channels Pancreatic secretion; Renin secretion 0 High Q3TCR7 Dynamin-2 OS=Mus musculus OX=10090 GN=Dnm2 PE=1 SV=1 0 2.541 1 1 1 1 869 97.9 7.44 1 1 216273.1094 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;nucleus catalytic activity;nucleotide binding;protein binding "Pf00169, Pf00350, Pf01031, Pf02212" 13430 ENSMUSG00000033335.17 Dnm2 9 0 Low A0A087WQU2 Retinoblastoma-binding protein 5 (Fragment) OS=Mus musculus OX=10090 GN=Rbbp5 PE=1 SV=1 0.054 0.978 7 1 1 1 107 12 5.39 1 1 98303.98438 192120.5469 182180.1719 127140.0547 1 1 1 1 protein binding Pf00400 ENSMUSG00000026439.14 1 0 Medium P56382 "ATP synthase subunit epsilon, mitochondrial OS=Mus musculus OX=10090 GN=Atp5f1e PE=1 SV=2" 0.032 1.213 13 1 1 1 52 5.8 10.01 1 1 86308.71875 171320.3281 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf04627 67126 ENSMUSG00000016252.7 Atp5e 2 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q61985 Endoplasmic reticulum membrane sensor NFE2L1 OS=Mus musculus OX=10090 GN=Nfe2l1 PE=1 SV=2 0 3.268 1 1 1 1 741 81.5 4.7 1 1 483764.8438 1 cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus DNA binding;protein binding "Pf00170, Pf03131, Pf07716" 18023 ENSMUSG00000038615.17 Nfe2l1 11 0 Medium P70677 Caspase-3 OS=Mus musculus OX=10090 GN=Casp3 PE=1 SV=1 0.034 1.175 2 1 1 1 277 31.5 6.92 1 1 94999.77344 97754.9375 568271.3125 1 1 1 cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;nucleus catalytic activity;enzyme regulator activity;protein binding Pf00656 12367 ENSMUSG00000031628.9 Casp3 8 Activation of caspases through apoptosome-mediated cleavage; Activation of DNA fragmentation factor; Cytochrome c-mediated apoptotic response; Caspase-mediated cleavage of cytoskeletal proteins; Ligand-independent caspase activation via DCC; Signaling by Hippo; NADE modulates death signalling; Signalling by NGF; Apoptotic cleavage of cell adhesion proteins; Other interleukin signaling; Apoptotic factor-mediated response AGE-RAGE signaling pathway in diabetic complications; Herpes simplex infection; Platinum drug resistance; p53 signaling pathway; MAPK signaling pathway; MicroRNAs in cancer; Amyotrophic lateral sclerosis (ALS); TNF signaling pathway; Toxoplasmosis; Tuberculosis; Hepatitis B; Huntington's disease; Apoptosis - multiple species; Non-alcoholic fatty liver disease (NAFLD); Pertussis; Proteoglycans in cancer; Parkinson's disease; Legionellosis; Pathways in cancer; Alzheimer's disease; Viral myocarditis; Natural killer cell mediated cytotoxicity; Amoebiasis; Colorectal cancer; Viral carcinogenesis; Serotonergic synapse; Apoptosis 0 Medium Q9DCL9 Multifunctional protein ADE2 OS=Mus musculus OX=10090 GN=Paics PE=1 SV=4 0.014 1.751 4 1 1 1 425 47 7.23 1 1 metabolic process cytoplasm;membrane catalytic activity;nucleotide binding;protein binding "Pf00731, Pf01259" 67054 ENSMUSG00000029247.17 Paics 5 Purine ribonucleoside monophosphate biosynthesis Metabolic pathways; Purine metabolism 0 Medium A0A494BAP3 Ferritin (Fragment) OS=Mus musculus OX=10090 GN=Fth1 PE=1 SV=1 0.028 1.294 12 1 1 1 59 6.8 6.77 1 1 133273.75 773148.5 885434.9375 758633.25 1 1 1 1 0 Medium D6RI83 U1 small nuclear ribonucleoprotein A OS=Mus musculus OX=10090 GN=Snrpa PE=1 SV=1 0.014 1.776 30 1 1 1 44 5 8.62 1 1 Met-loss+Acetyl [N-Term] ENSMUSG00000061479.15 7 0 Medium A0A494B9H1 Nucleotide exchange factor SIL1 OS=Mus musculus OX=10090 GN=Sil1 PE=1 SV=1 0.027 1.332 3 1 1 1 417 46.8 6 1 1 157178.8594 438414.8438 1054544.5 1 1 1 0 High E9Q456 Tropomyosin alpha-1 chain OS=Mus musculus OX=10090 GN=Tpm1 PE=1 SV=1 0 2.375 4 1 1 1 248 28.7 4.77 1 1 905969.8125 2252666.25 2298694.25 1199069.5 1 1 1 1 "Pf00261, Pf12718" ENSMUSG00000032366.15 9 0 High O70475 UDP-glucose 6-dehydrogenase OS=Mus musculus OX=10090 GN=Ugdh PE=1 SV=1 0 2.383 2 1 1 1 493 54.8 7.56 1 1 210017.0938 438102.7813 1 1 metabolic process cytosol;nucleus catalytic activity;nucleotide binding "Pf00984, Pf03720, Pf03721" 22235 ENSMUSG00000029201.14 Ugdh 5 "Formation of the active cofactor, UDP-glucuronate" Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions 0 Medium P46467 Vacuolar protein sorting-associated protein 4B OS=Mus musculus OX=10090 GN=Vps4b PE=1 SV=2 0.034 1.183 2 1 1 1 444 49.4 7.11 1 1 355754.0938 1 cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;membrane;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401" 20479 ENSMUSG00000009907.17 Vps4b 1 Endosomal Sorting Complex Required For Transport (ESCRT) Endocytosis 0 Low Q8BH82 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Mus musculus OX=10090 GN=Napepld PE=1 SV=1 0.058 0.836 2 1 1 1 396 45.8 5.94 1 1 3070454.5 2475436 3132244.25 1 1 1 metabolic process;response to stimulus cytosol;membrane catalytic activity;metal ion binding;protein binding "Pf00753, Pf12706, Pf13483" 242864 ENSMUSG00000044968.16 Napepld 5 Retrograde endocannabinoid signaling 0 Medium P62876 "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Mus musculus OX=10090 GN=Polr2l PE=3 SV=1" 0.042 1.096 13 1 1 1 67 7.6 7.77 1 1 72325.15625 528308.9375 533135.5 693912.25 1 1 1 1 metabolic process nucleus catalytic activity;DNA binding;metal ion binding Pf01194 66491 ENSMUSG00000038489.8 Polr2l 7 mRNA Capping; RNA Polymerase II Transcription Initiation; Transcriptional regulation by small RNAs; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Termination; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; RNA Pol II CTD phosphorylation and interaction with CE; FGFR2 alternative splicing; RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; RNA Polymerase III Transcription Initiation From Type 1 Promoter; Dual incision in TC-NER; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA polymerase II transcribes snRNA genes; Formation of the Early Elongation Complex; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase I Promoter Escape; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Purine metabolism; Huntington's disease; Pyrimidine metabolism; Cytosolic DNA-sensing pathway 0 Medium Q61495 Desmoglein-1-alpha OS=Mus musculus OX=10090 GN=Dsg1a PE=2 SV=2 0.021 1.554 1 1 1 1 1057 114.5 4.89 1 1 426680.5313 279698.0625 357678.6875 301653.1563 1 1 1 1 membrane metal ion binding;protein binding "Pf00028, Pf01049" 13510 ENSMUSG00000069441.3 Dsg1a 18 Formation of the cornified envelope; Neutrophil degranulation; Apoptotic cleavage of cell adhesion proteins Staphylococcus aureus infection 0 High Q3TCH7 Cullin-4A OS=Mus musculus OX=10090 GN=Cul4a PE=1 SV=1 0 2.861 2 1 1 1 759 87.7 8.35 1 1 metabolic process;regulation of biological process;response to stimulus catalytic activity;protein binding "Pf00888, Pf10557" 99375 ENSMUSG00000031446.14 Cul4a 8 Dual incision in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER Ubiquitin mediated proteolysis; Nucleotide excision repair 0 High E9PW20 Chromatin target of PRMT1 protein OS=Mus musculus OX=10090 GN=Chtop PE=1 SV=1 0 3.068 6 1 1 1 203 22.1 11.97 1 1 metabolic process;regulation of biological process nucleus protein binding;RNA binding Pf13865 66511 ENSMUSG00000001017.15 Chtop 3 0 High Q9JK53 Prolargin OS=Mus musculus OX=10090 GN=Prelp PE=1 SV=2 0 3.554 3 1 1 1 378 43.3 9.54 1 1 551870.625 1 cell organization and biogenesis extracellular protein binding;structural molecule activity "Pf01462, Pf12799, Pf13855" 116847 ENSMUSG00000041577.5 Prelp 1 Keratan sulfate degradation; Keratan sulfate biosynthesis 0 Medium A6H6A9 Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 0.049 1.016 1 1 1 1 815 92.3 5.31 1 1 197507.2813 719193.5625 6462368.5 1 1 1 regulation of biological process;transport endosome;Golgi;nucleus enzyme regulator activity;protein binding "Pf00566, Pf00640, Pf12473" 29809 ENSMUSG00000026721.15 Rabgap1l 1 0 Low Q99L90 Microspherule protein 1 OS=Mus musculus OX=10090 GN=Mcrs1 PE=1 SV=1 0.052 0.999 7 1 1 1 462 51.7 9.32 1 1 1071936.375 473813.3438 1 1 Met-loss [N-Term] cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;nucleus catalytic activity;enzyme regulator activity;protein binding;RNA binding "Pf00498, Pf13325" 51812 ENSMUSG00000037570.15 Mcrs1 15 HATs acetylate histones; UCH proteinases; DNA Damage Recognition in GG-NER Herpes simplex infection 0 High Q9R0Q9 Mannose-P-dolichol utilization defect 1 protein OS=Mus musculus OX=10090 GN=Mpdu1 PE=1 SV=1 0 2.842 4 1 1 1 247 26.5 8.75 1 1 646204.3125 1 metabolic process;transport membrane Pf04193 24070 Mpdu1 11 0 High P14206 40S ribosomal protein SA OS=Mus musculus OX=10090 GN=Rpsa PE=1 SV=4 0.008 1.973 4 1 1 1 295 32.8 4.87 1 1 707749.9375 1 cell differentiation;cell organization and biogenesis;metabolic process;transport cytoplasm;cytosol;membrane;nucleus;ribosome protein binding;receptor activity;RNA binding;structural molecule activity Pf00318 16785; 100045332; 102642689 ENSMUSG00000032518.6 Rpsa; LOC100045332; LOC100505031; LOC102642689 9; 19 "L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Formation of the ternary complex, and subsequently, the 43S complex; Translation initiation complex formation" Ribosome 0 High F7D1R5 Phospholipase A-2-activating protein (Fragment) OS=Mus musculus OX=10090 GN=Plaa PE=1 SV=1 0.01 1.899 4 1 1 1 214 23.5 5.01 1 1 352657.4375 1 "Pf08324, Pf09070" ENSMUSG00000028577.13 4 0 Medium Q9CPU4 Microsomal glutathione S-transferase 3 OS=Mus musculus OX=10090 GN=Mgst3 PE=1 SV=1 0.015 1.692 10 1 1 1 153 16.9 9.5 1 1 92553.10938 194823.7031 307304.9375 1 1 1 metabolic process;response to stimulus endoplasmic reticulum;membrane antioxidant activity;catalytic activity Pf01124 66447 ENSMUSG00000026688.5 Mgst3 1 Glutathione conjugation; Aflatoxin activation and detoxification Glutathione metabolism; Platinum drug resistance; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450 0 High Q8R1I1 Cytochrome b-c1 complex subunit 9 OS=Mus musculus OX=10090 GN=Uqcr10 PE=1 SV=1 0 6.147 27 1 1 1 64 7.4 9.19 1 1 263382.0938 299854.0313 336677.5938 2063262.875 1 1 1 1 cell organization and biogenesis;metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf05365 66152 ENSMUSG00000059534.8 Uqcr10 11 Respiratory electron transport Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 Medium H3BKF3 PAN2-PAN3 deadenylation complex subunit PAN3 OS=Mus musculus OX=10090 GN=Pan3 PE=1 SV=1 0.032 1.267 4 1 1 1 887 95.4 8.34 1 1 969084.5625 1320325.75 971754.75 1 1 1 metabolic process;regulation of biological process;transport cytoplasm catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding "Pf00069, Pf00642" 72587 ENSMUSG00000029647.15 Pan3 5 0 Medium D3Z2B1 Low-density lipoprotein receptor-related protein 11 OS=Mus musculus OX=10090 GN=Lrp11 PE=1 SV=1 0.032 1.239 1 1 1 1 438 47.4 8.38 1 1 55879.34766 137912.9063 171244.9844 241228.3125 1 1 1 1 protein binding "Pf00057, Pf07502" ENSMUSG00000019796.12 10 0 High Q9CX53 Gem-associated protein 6 OS=Mus musculus OX=10090 GN=Gemin6 PE=1 SV=2 0.004 2.137 8 1 1 1 166 18.7 5.25 1 1 cell organization and biogenesis;metabolic process cytoplasm;cytosol;nucleus protein binding Pf06372 67242 ENSMUSG00000055760.12 Gemin6 17 snRNP Assembly RNA transport 0 Low Q99ME2 WD repeat-containing protein 6 OS=Mus musculus OX=10090 GN=Wdr6 PE=1 SV=1 0.056 0.946 1 1 1 1 1125 121.8 6.98 1 1 208083.0781 167483.4219 220451.6875 1 1 1 regulation of biological process cytoplasm;cytosol;membrane protein binding;RNA binding Pf00400 83669 ENSMUSG00000066357.6 Wdr6 9 0 Low A0A2I3BQZ9 Amyloid-beta A4 protein OS=Mus musculus OX=10090 GN=App PE=1 SV=1 0.058 0.824 1 1 1 1 751 84.6 4.79 1 1 1054106.125 8825190 1 1 0 Medium Q3UG20 Inactive histone-lysine N-methyltransferase 2E OS=Mus musculus OX=10090 GN=Kmt2e PE=1 SV=2 0.043 1.081 0 1 1 1 1868 204.4 7.42 1 1 283381.7813 178295.1406 338246.9063 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport nucleus catalytic activity;metal ion binding;protein binding;transporter activity "Pf00430, Pf00628, Pf00856, Pf09770" 69188 ENSMUSG00000029004.15 Kmt2e; Mll5 5 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines Lysine degradation 0 High A0A494BB38 Prostaglandin reductase-3 OS=Mus musculus OX=10090 GN=Zadh2 PE=1 SV=1 0 4.792 5 1 1 1 254 27.2 6.54 1 1 130766.4141 180788.8281 526724.8125 1 1 1 0 High A0A1B0GR08 Gamma-tubulin complex component (Fragment) OS=Mus musculus OX=10090 GN=Tubgcp2 PE=1 SV=1 0 3.197 1 1 1 1 900 102.7 6.77 1 1 cell organization and biogenesis cytoplasm;cytoskeleton protein binding Pf04130 ENSMUSG00000025474.9 7 0 High A0A140LHG0 AP-2 complex subunit alpha-1 OS=Mus musculus OX=10090 GN=Ap2a1 PE=4 SV=1 0.007 2.061 26 1 1 1 38 4.2 4.61 1 1 protein binding ENSMUSG00000060279.14 7 0 Medium A0A3Q4EGQ6 Protein SSXT OS=Mus musculus OX=10090 GN=Ss18 PE=1 SV=1 0.012 1.868 20 1 1 1 61 6.9 8.35 1 1 114484.6953 322496 389453.6563 1 1 1 0 High Q80ZK0 "28S ribosomal protein S10, mitochondrial OS=Mus musculus OX=10090 GN=Mrps10 PE=1 SV=1" 0 5.317 11 1 1 1 160 18.7 8.84 1 1 metabolic process mitochondrion;ribosome structural molecule activity Pf00338 64657 Mrps10 17 0 Medium F6YY19 PAX3- and PAX7-binding protein 1 (Fragment) OS=Mus musculus OX=10090 GN=Paxbp1 PE=1 SV=1 0.034 1.189 3 1 1 1 450 50.7 5.4 1 1 regulation of biological process nucleus DNA binding;protein binding ENSMUSG00000022974.12 16 0 Medium F6WMD1 Alpha-2-macroglobulin receptor-associated protein (Fragment) OS=Mus musculus OX=10090 GN=Lrpap1 PE=1 SV=1 0.027 1.357 5 1 1 1 153 18.3 8.32 1 1 615429.5 1 endoplasmic reticulum protein binding "Pf06400, Pf06401" ENSMUSG00000029103.16 5 0 Medium P30731 Probable G-protein coupled receptor 83 OS=Mus musculus OX=10090 GN=Gpr83 PE=2 SV=2 0.027 1.348 4 1 1 1 423 48.1 9.36 1 1 regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity Pf00001 14608 ENSMUSG00000031932.14 Gpr83 9 G alpha (s) signalling events Neuroactive ligand-receptor interaction 0 Medium V9GX87 Double-stranded RNA-binding protein Staufen homolog 1 OS=Mus musculus OX=10090 GN=Stau1 PE=1 SV=1 0.046 1.067 2 1 1 1 436 48.7 9.86 1 1 4755288 9452223 9066605 10417067 1 1 1 1 RNA binding "Pf00035, Pf14709" ENSMUSG00000039536.16 2 0 High P09671 "Superoxide dismutase [Mn], mitochondrial OS=Mus musculus OX=10090 GN=Sod2 PE=1 SV=3" 0 5.284 6 1 1 1 222 24.6 8.62 1 1 462500.5 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;organelle lumen antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding "Pf00081, Pf02777" 20656 ENSMUSG00000006818.4 Sod2 17 Transcriptional activation of mitochondrial biogenesis; Detoxification of Reactive Oxygen Species FoxO signaling pathway; Longevity regulating pathway; Huntington's disease; Longevity regulating pathway - multiple species; Peroxisome 0 High Q9DAC2 Complement component C8 gamma chain OS=Mus musculus OX=10090 GN=C8g PE=1 SV=1 0.008 1.954 13 1 1 1 168 18.9 8.32 1 1 199185.5938 295851.5313 575005.25 1 1 1 defense response;metabolic process;regulation of biological process;response to stimulus extracellular protein binding Pf00061 69379 ENSMUSG00000015083.11 C8g 2 Complement and coagulation cascades; Prion diseases; Systemic lupus erythematosus; Amoebiasis 0 High O08792 Transcription factor COE2 OS=Mus musculus OX=10090 GN=Ebf2 PE=1 SV=4 0.008 1.968 3 1 1 1 575 62.6 9.06 1 1 cell differentiation;development;metabolic process;regulation of biological process nucleus DNA binding;metal ion binding;protein binding Pf01833 13592 ENSMUSG00000022053.13 Ebf2 14 0 Low Q99LP6 "GrpE protein homolog 1, mitochondrial OS=Mus musculus OX=10090 GN=Grpel1 PE=1 SV=1" 0.058 0.86 4 1 1 1 217 24.3 8.38 1 1 291938.0938 4533087 1 1 metabolic process;regulation of biological process;transport mitochondrion;nucleus;organelle lumen enzyme regulator activity;nucleotide binding;protein binding Pf01025 17713 ENSMUSG00000029198.3 Grpel1 5 0 Medium D3YXN4 Heme oxygenase 2 (Fragment) OS=Mus musculus OX=10090 GN=Hmox2 PE=1 SV=1 0.022 1.465 10 1 1 1 93 10.6 4.91 1 1 304652.6563 1 metabolic process catalytic activity Pf01126 ENSMUSG00000004070.15 16 0 High P56392 "Cytochrome c oxidase subunit 7A1, mitochondrial OS=Mus musculus OX=10090 GN=Cox7a1 PE=1 SV=1" 0 3.985 16 1 1 1 80 9 9.79 1 1 80530.89063 1857479.875 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf02238 12865 ENSMUSG00000074218.3 Cox7a1 7 Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease; Cardiac muscle contraction 0 High Q3UI84 Replication factor C subunit 4 OS=Mus musculus OX=10090 GN=Rfc4 PE=1 SV=1 0 2.674 3 1 1 1 370 40.9 8.53 1 1 221895.0156 457146.0313 486408.5625 427769.0625 1 1 1 1 metabolic process;regulation of biological process;response to stimulus membrane;nucleus catalytic activity;DNA binding;nucleotide binding;protein binding "Pf00004, Pf03215, Pf05496, Pf08542, Pf09848, Pf13086, Pf13177, Pf13191, Pf13245, Pf13401, Pf13481, Pf13604" 106344 ENSMUSG00000022881.14 Rfc4 16 0 High Q9JIX8 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus OX=10090 GN=Acin1 PE=1 SV=3 0 2.274 1 1 1 1 1338 150.6 5.91 1 1 182649.1719 753158.5 746748.8125 236067 1 1 1 1 cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytosol;membrane;nucleus RNA binding "Pf02037, Pf13893" 56215 ENSMUSG00000022185.18 Acin1 14 Apoptotic cleavage of cellular proteins mRNA surveillance pathway; Spliceosome; RNA transport 0 Medium B7ZCA9 "Transcription elongation factor, mitochondrial (Fragment) OS=Mus musculus OX=10090 GN=Tefm PE=1 SV=8" 0.036 1.139 3 1 1 1 221 25.3 9.76 1 1 56684.02734 115576.9063 1 1 Pf12836 ENSMUSG00000046909.9 11 0 Low E9PV45 Ubiquitin carboxyl-terminal hydrolase 24 OS=Mus musculus OX=10090 GN=Usp24 PE=1 SV=1 0.052 0.999 0 1 1 1 2618 293.9 6.21 1 1 402557.9688 1 metabolic process catalytic activity;protein binding "Pf00443, Pf13423" ENSMUSG00000028514.15 4 0 High Q9D1H9 Microfibril-associated glycoprotein 4 OS=Mus musculus OX=10090 GN=Mfap4 PE=1 SV=1 0 5.882 7 1 1 1 257 28.9 5.44 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus extracellular Pf00147 76293 ENSMUSG00000042436.12 Mfap4 11 Molecules associated with elastic fibres 0 Medium Q9D0D4 Probable dimethyladenosine transferase OS=Mus musculus OX=10090 GN=Dimt1 PE=2 SV=1 0.022 1.475 3 1 1 1 313 35.3 9.99 1 1 262863.5313 164262.8125 471738.375 1 1 1 metabolic process;regulation of biological process cytosol;nucleus;organelle lumen catalytic activity;RNA binding "Pf00398, Pf13659" 66254 ENSMUSG00000021692.8 Dimt1 13 0 Medium A0A0R4J008 Histone deacetylase 2 OS=Mus musculus OX=10090 GN=Hdac2 PE=1 SV=1 0.021 1.532 4 1 1 1 488 55.3 5.91 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus chromosome;cytoplasm;nucleus catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding Pf00850 15182 ENSMUSG00000019777.16 Hdac2 10 Regulation of PTEN gene transcription; Regulation of TP53 Activity through Acetylation; Factors involved in megakaryocyte development and platelet production; RNA Polymerase I Transcription Initiation; SUMOylation of chromatin organization proteins Epstein-Barr virus infection; Huntington's disease; Transcriptional misregulation in cancer; Notch signaling pathway; Thyroid hormone signaling pathway; Cell cycle; Pathways in cancer; Alcoholism; Viral carcinogenesis; Chronic myeloid leukemia; Longevity regulating pathway - multiple species 0 Low Q920L1 Acyl-CoA (8-3)-desaturase OS=Mus musculus OX=10090 GN=Fads1 PE=1 SV=1 0.057 0.891 4 1 1 1 447 52.3 9.29 1 1 Met-loss [N-Term] cell communication;metabolic process;response to stimulus;transport endoplasmic reticulum;membrane;mitochondrion;nucleus catalytic activity "Pf00173, Pf00487" 76267 ENSMUSG00000010663.4 Fads1 19 alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism Fatty acid metabolism; Biosynthesis of unsaturated fatty acids 0 High Q9ER38 Torsin-3A OS=Mus musculus OX=10090 GN=Tor3a PE=1 SV=2 0 2.238 2 1 1 1 385 43.8 6.28 1 1 1040039.75 1 cytoplasm;endoplasmic reticulum;organelle lumen catalytic activity;nucleotide binding;protein binding Pf06309 30935 ENSMUSG00000060519.11 Tor3a 1 0 Medium A0A0N4SV00 T-complex protein 1 subunit eta OS=Mus musculus OX=10090 GN=Cct7 PE=1 SV=1 0.016 1.643 1 1 1 1 502 55 7.83 1 1 160829.6094 235764.7188 178623.5938 570694 1 1 1 1 metabolic process;transport cytoplasm;mitochondrion nucleotide binding;protein binding Pf00118 ENSMUSG00000030007.8 6 0 Medium E9Q9B0 Kinesin-like protein KIF1C OS=Mus musculus OX=10090 GN=Kif1c PE=1 SV=1 0.034 1.19 1 1 1 1 1112 123.7 6.93 1 1 594497.5625 423006.25 1 1 cellular component movement;transport Golgi catalytic activity;motor activity;nucleotide binding;protein binding "Pf00225, Pf00498" ENSMUSG00000020821.17 11 0 Medium Q2YDW2 Protein misato homolog 1 OS=Mus musculus OX=10090 GN=Msto1 PE=1 SV=1 0.012 1.82 1 1 1 1 556 61.2 6.49 1 1 459585.4063 1 cell organization and biogenesis cytoplasm;membrane;mitochondrion catalytic activity "Pf00091, Pf10644, Pf14881" 229524 Msto1 3 0 Medium Q9DCN2 NADH-cytochrome b5 reductase 3 OS=Mus musculus OX=10090 GN=Cyb5r3 PE=1 SV=3 0.022 1.49 3 1 1 1 301 34.1 8.38 1 1 458378.5313 506636.1563 480488.9063 1 1 1 metabolic process cytoplasm;endoplasmic reticulum;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00175, Pf00970" 109754 ENSMUSG00000018042.17 Cyb5r3 15 Phase I - Functionalization of compounds; Neutrophil degranulation; Vitamin C (ascorbate) metabolism Amino sugar and nucleotide sugar metabolism 0 High P29788 Vitronectin OS=Mus musculus OX=10090 GN=Vtn PE=1 SV=2 0 4.393 4 1 1 1 478 54.8 5.88 1 1 cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;endoplasmic reticulum;extracellular;organelle lumen protein binding;receptor activity "Pf00045, Pf01033" 22370 ENSMUSG00000017344.4 Vtn 11 Regulation of Complement cascade; ECM proteoglycans; Molecules associated with elastic fibres; Syndecan interactions; Integrin cell surface interactions Focal adhesion; Complement and coagulation cascades; Proteoglycans in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway 0 Medium O88630 Golgi SNAP receptor complex member 1 OS=Mus musculus OX=10090 GN=Gosr1 PE=1 SV=2 0.016 1.657 3 1 1 1 250 28.5 9.29 1 1 cell organization and biogenesis;regulation of biological process;transport cytosol;Golgi;membrane protein binding Pf12352 53334 ENSMUSG00000010392.8 Gosr1 11 COPI-mediated anterograde transport; Intra-Golgi traffic SNARE interactions in vesicular transport 0 High Q8JZN7 Mitochondrial Rho GTPase 2 OS=Mus musculus OX=10090 GN=Rhot2 PE=1 SV=1 0 3.521 3 1 1 1 620 69 6 1 1 432650.9688 1 cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport membrane;mitochondrion catalytic activity;metal ion binding;nucleotide binding "Pf00071, Pf08355, Pf08356, Pf08477" 214952 ENSMUSG00000025733.17 Rhot2 17 Rho GTPase cycle 0 High Q9Z1P8 Angiopoietin-related protein 4 OS=Mus musculus OX=10090 GN=Angptl4 PE=1 SV=1 0 2.36 3 1 1 1 410 45.5 8.13 1 1 545284.6875 949540.5625 543252.0625 741883.25 1 1 1 1 cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus extracellular enzyme regulator activity;protein binding "Pf00147, Pf08702" 57875 ENSMUSG00000002289.15 Angptl4 17 Assembly of active LPL and LIPC lipase complexes PPAR signaling pathway 0 Medium O55022 Membrane-associated progesterone receptor component 1 OS=Mus musculus OX=10090 GN=Pgrmc1 PE=1 SV=4 0.021 1.559 4 1 1 1 195 21.7 4.7 1 1 regulation of biological process;response to stimulus endoplasmic reticulum;membrane Pf00173 53328 ENSMUSG00000006373.10 Pgrmc1 X Neutrophil degranulation 0 High Q06185 "ATP synthase subunit e, mitochondrial OS=Mus musculus OX=10090 GN=Atp5me PE=1 SV=2" 0 3.676 17 1 1 1 71 8.2 9.35 1 1 1141124.625 1632550.625 3715238.75 1 1 1 metabolic process;transport membrane;mitochondrion catalytic activity;transporter activity Pf05680 11958 ENSMUSG00000050856.16 Atp5k 5 Cristae formation; Formation of ATP by chemiosmotic coupling Metabolic pathways; Oxidative phosphorylation 0 High A2AR15 Target of rapamycin complex 2 subunit MAPKAP1 (Fragment) OS=Mus musculus OX=10090 GN=Mapkap1 PE=1 SV=8 0.01 1.878 3 1 1 1 306 34.4 5.68 1 1 Pf05422 ENSMUSG00000038696.14 2 0 High D3Z7R9 Cell cycle progression protein 1 OS=Mus musculus OX=10090 GN=Ccpg1 PE=1 SV=1 0 4.802 2 1 1 1 778 89.1 6.06 1 1 71012.78125 428054.1563 1 1 regulation of biological process membrane protein binding 72278 ENSMUSG00000034563.16 Ccpg1 9 0 Medium Q8VCS3 Glycosaminoglycan xylosylkinase OS=Mus musculus OX=10090 GN=Fam20b PE=1 SV=1 0.021 1.565 2 1 1 1 409 46.6 6.95 1 1 339525.9375 1 metabolic process Golgi;membrane catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding Pf06702 215015 ENSMUSG00000033557.17 Fam20b 1 0 High Q9QUR7 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Mus musculus OX=10090 GN=Pin1 PE=1 SV=1 0 2.231 9 1 1 1 165 18.4 8.79 1 1 227008.8438 412140.125 290446.875 1 1 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process cytoplasm;cytosol;mitochondrion;nucleus catalytic activity;motor activity;protein binding "Pf00397, Pf00639, Pf13145, Pf13616" 23988 ENSMUSG00000032171.7 Pin1 9 Regulation of TP53 Activity through Phosphorylation; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation RIG-I-like receptor signaling pathway 0 High P61804 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Mus musculus OX=10090 GN=Dad1 PE=1 SV=3 0 4.365 11 1 1 1 113 12.5 7.08 1 1 144922.3438 581876.375 1 1 cell death;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf02109 13135 ENSMUSG00000022174.8 Dad1 14 Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum 0 High Q9D1R1 "Complex I assembly factor TMEM126B, mitochondrial OS=Mus musculus OX=10090 GN=Tmem126b PE=1 SV=1" 0 2.955 6 1 1 1 230 25.4 9.51 1 1 576276.25 1 membrane;mitochondrion Pf07114 68472 ENSMUSG00000030614.8 Tmem126b 7 Complex I biogenesis 0 High Q9WV55 Vesicle-associated membrane protein-associated protein A OS=Mus musculus OX=10090 GN=Vapa PE=1 SV=2 0.006 2.104 6 1 1 1 249 27.8 8.4 1 1 124715.4219 469294.0625 1 1 cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoskeleton;endoplasmic reticulum;membrane;nucleus protein binding;signal transducer activity Pf00635 30960 ENSMUSG00000024091.8 Vapa 17 Neutrophil degranulation; Sphingolipid de novo biosynthesis Tight junction 0 High A0A2R8VJX4 "Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Mus musculus OX=10090 GN=Alg10b PE=1 SV=1" 0.001 2.202 12 1 1 1 156 17.9 7.75 1 1 379454.3125 498896.125 566358.75 388659.5625 1 1 1 1 0 Low Q3TCT4 Ectonucleoside triphosphate diphosphohydrolase 7 OS=Mus musculus OX=10090 GN=Entpd7 PE=2 SV=1 0.053 0.983 5 1 1 1 606 68.9 7.72 1 1 metabolic process membrane;nucleus catalytic activity;metal ion binding Pf01150 93685 ENSMUSG00000025192.13 Entpd7 19 Phosphate bond hydrolysis by NTPDase proteins 0 High Q9CRC0 Vitamin K epoxide reductase complex subunit 1 OS=Mus musculus OX=10090 GN=Vkorc1 PE=1 SV=1 0 3.414 8 1 1 1 161 17.8 9.14 1 1 240175.6719 207027.125 1091132.25 1 1 1 coagulation;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity Pf07884 27973 ENSMUSG00000096145.2 Vkorc1 7 Metabolism of vitamin K Ubiquinone and other terpenoid-quinone biosynthesis 0 High A0A0R4J066 "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial OS=Mus musculus OX=10090 GN=Coq10b PE=1 SV=1" 0 3.802 6 1 1 1 242 27.5 9.29 1 1 351667.7188 1 metabolic process membrane;mitochondrion Pf03364 67876 ENSMUSG00000025981.13 Coq10b 1 Respiratory electron transport 0 Medium Q6PD26 GPI transamidase component PIG-S OS=Mus musculus OX=10090 GN=Pigs PE=1 SV=3 0.014 1.718 1 1 1 1 555 61.7 6.93 1 1 95988.65625 130228.0859 588007 1 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity Pf10510 276846 ENSMUSG00000041958.10 Pigs 11 Attachment of GPI anchor to uPAR Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways 0 High P58021 Transmembrane 9 superfamily member 2 OS=Mus musculus OX=10090 GN=Tm9sf2 PE=1 SV=1 0 3.126 2 1 1 1 662 75.3 7.43 1 1 299399.5938 1 transport endosome;membrane "Pf02990, Pf07690" 68059 ENSMUSG00000025544.13 Tm9sf2 14 0 High A0A0J9YU39 Prolactin regulatory element-binding protein (Fragment) OS=Mus musculus OX=10090 GN=Preb PE=1 SV=1 0.007 2.034 6 1 1 1 186 20.7 7.84 1 1 989635.1875 1 enzyme regulator activity;protein binding ENSMUSG00000045302.13 5 0 Medium Q9CQC7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Mus musculus OX=10090 GN=Ndufb4 PE=1 SV=3 0.032 1.242 10 1 1 1 129 15.1 9.89 1 1 cell organization and biogenesis;metabolic process;response to stimulus;transport membrane;mitochondrion catalytic activity Pf07225 100041273; 68194; 100042503 ENSMUSG00000022820.3 Gm3244; Ndufb4; Gm3873 15; 16; 19 Complex I biogenesis Metabolic pathways; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Oxidative phosphorylation; Parkinson's disease; Alzheimer's disease 0 High Q924T2 "28S ribosomal protein S2, mitochondrial OS=Mus musculus OX=10090 GN=Mrps2 PE=1 SV=1" 0.008 1.939 7 1 1 1 291 32.3 9.14 1 1 221023.25 440518.7813 1 1 cell organization and biogenesis;metabolic process mitochondrion;ribosome structural molecule activity Pf00318 118451 ENSMUSG00000035772.11 Mrps2 2 Mitochondrial translation termination; Mitochondrial translation elongation Ribosome 0 High Q9D0T1 NHP2-like protein 1 OS=Mus musculus OX=10090 GN=Snu13 PE=1 SV=4 0 2.343 13 1 1 1 128 14.2 8.46 1 1 253698.4531 480375.1875 335697.9688 1 1 1 cell organization and biogenesis;metabolic process membrane;nucleus;spliceosomal complex protein binding;RNA binding Pf01248 20826; 100862468 ENSMUSG00000063480.7 Nhp2l1; Snu13; LOC100862468 15; 4 mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Major pathway of rRNA processing in the nucleolus and cytosol Spliceosome; Ribosome biogenesis in eukaryotes 0 Low Q5SUE8 Ankyrin repeat domain-containing protein 40 OS=Mus musculus OX=10090 GN=Ankrd40 PE=1 SV=1 0.054 0.978 2 1 1 1 363 40.5 5.1 1 1 297381.9375 1 Met-loss+Acetyl [N-Term] protein binding "Pf00023, Pf12796, Pf13606, Pf13637, Pf13857" 71452 ENSMUSG00000020864.13 Ankrd40 11 0 High Q91YN9 BAG family molecular chaperone regulator 2 OS=Mus musculus OX=10090 GN=Bag2 PE=1 SV=1 0 2.523 4 1 1 1 210 23.5 6.42 1 1 99048.74219 84739.96875 181235.1563 569793.5625 1 1 1 1 metabolic process;regulation of biological process enzyme regulator activity;nucleotide binding;protein binding Pf02179 213539 ENSMUSG00000042215.8 Bag2 1 Protein processing in endoplasmic reticulum 0 Medium Q9EQI8 "39S ribosomal protein L46, mitochondrial OS=Mus musculus OX=10090 GN=Mrpl46 PE=1 SV=1" 0.022 1.459 2 1 1 1 283 32.1 7.4 1 1 57830.00781 88678.73438 115953.2266 202017.2031 1 1 1 1 mitochondrion;ribosome catalytic activity;structural molecule activity Pf11788 67308 ENSMUSG00000030612.6 Mrpl46 7 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q9D0I9 "Arginine--tRNA ligase, cytoplasmic OS=Mus musculus OX=10090 GN=Rars1 PE=1 SV=2" 0 4.013 2 1 1 1 660 75.6 7.55 1 1 425201.9063 1 metabolic process cytoplasm;cytosol;membrane;mitochondrion;nucleus catalytic activity;nucleotide binding;protein binding;RNA binding "Pf00750, Pf03485, Pf05746" 104458 ENSMUSG00000018848.4 Rars 11 Aminoacyl-tRNA biosynthesis 0 Medium Q3TFP0 Serine/arginine-rich-splicing factor 10 OS=Mus musculus OX=10090 GN=Srsf10 PE=1 SV=1 0.014 1.77 7 1 1 1 182 22.1 10.33 1 1 226381.4531 151327.1719 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;transport cytosol;nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 14105 ENSMUSG00000028676.17 Srsf10 4 0 Medium Q9CX98 Cytochrome P450 2U1 OS=Mus musculus OX=10090 GN=Cyp2u1 PE=2 SV=2 0.027 1.373 3 1 1 1 530 60.5 8.27 1 1 516598.8438 567115.6875 509230.4688 522904.7188 1 1 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity;metal ion binding Pf00067 71519 ENSMUSG00000027983.13 Cyp2u1 3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE); Miscellaneous substrates Metabolic pathways; Arachidonic acid metabolism 0 High Q9CY16 "28S ribosomal protein S28, mitochondrial OS=Mus musculus OX=10090 GN=Mrps28 PE=1 SV=1" 0.006 2.066 5 1 1 1 186 20.5 8.92 1 1 232096.875 157858.5625 550517.125 1 1 1 mitochondrion;ribosome RNA binding Pf10246 66230 ENSMUSG00000040269.5 Mrps28 3 Mitochondrial translation termination; Mitochondrial translation elongation 0 High Q9DBH5 Vesicular integral-membrane protein VIP36 OS=Mus musculus OX=10090 GN=Lman2 PE=1 SV=2 0 2.464 3 1 1 1 358 40.4 6.95 1 1 38512.01172 144470.6406 125091.4063 1028981.938 1 1 1 1 regulation of biological process;transport cell surface;Golgi;membrane metal ion binding;protein binding Pf03388 66890 ENSMUSG00000021484.7 Lman2 13 Protein processing in endoplasmic reticulum 0 High P22437 Prostaglandin G/H synthase 1 OS=Mus musculus OX=10090 GN=Ptgs1 PE=1 SV=1 0 3.295 2 1 1 1 602 69 6.83 1 1 236865.5469 1 cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus antioxidant activity;catalytic activity;metal ion binding;protein binding "Pf00008, Pf03098, Pf07974" 19224 ENSMUSG00000047250.13 Ptgs1 2 Synthesis of Prostaglandins (PG) and Thromboxanes (TX); COX reactions Regulation of lipolysis in adipocytes; Metabolic pathways; Platelet activation; Arachidonic acid metabolism; Serotonergic synapse 0 High Q8BKE6 Cytochrome P450 20A1 OS=Mus musculus OX=10090 GN=Cyp20a1 PE=1 SV=1 0 2.412 2 1 1 1 462 52.1 6.95 1 1 619266.5 1 metabolic process membrane catalytic activity;metal ion binding Pf00067 77951 ENSMUSG00000049439.13 Cyp20a1 1 0 Medium Q01149 Collagen alpha-2(I) chain OS=Mus musculus OX=10090 GN=Col1a2 PE=1 SV=2 0.034 1.171 1 1 1 1 1372 129.5 9.19 1 1 615733.3125 1 cell organization and biogenesis;regulation of biological process;response to stimulus endoplasmic reticulum;extracellular metal ion binding;protein binding;structural molecule activity "Pf01391, Pf01410" 12843 ENSMUSG00000029661.16 Col1a2 6 Anchoring fibril formation; ECM proteoglycans; Cell surface interactions at the vascular wall; Platelet Aggregation (Plug Formation); Integrin cell surface interactions; Collagen degradation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Crosslinking of collagen fibrils; Collagen chain trimerization; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; MET activates PTK2 signaling; GPVI-mediated activation cascade; Non-integrin membrane-ECM interactions AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Protein digestion and absorption; Platelet activation; Proteoglycans in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Amoebiasis 0 High Q6NXW6 Cell cycle checkpoint protein RAD17 OS=Mus musculus OX=10090 GN=Rad17 PE=1 SV=2 0 2.487 2 1 1 1 688 77.3 6.14 1 1 1847494.25 1780729.375 2263286 1666228.25 1 1 1 1 development;metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;nucleotide binding;RNA binding "Pf00004, Pf00005, Pf00910, Pf03205, Pf03215, Pf13173, Pf13191, Pf13207, Pf13238, Pf13245, Pf13521" 19356 ENSMUSG00000021635.13 Rad17 13 HDR through Single Strand Annealing (SSA); G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange 0 Medium Q3UU43 Hexosyltransferase OS=Mus musculus OX=10090 GN=Chpf2 PE=1 SV=1 0.014 1.708 1 1 1 1 768 85.6 7.72 1 1 64275.8125 59983.91406 787197.6875 1 1 1 Golgi;membrane catalytic activity "Pf02434, Pf05679" 100910 ENSMUSG00000038181.16 Chpf2 5 Chondroitin sulfate biosynthesis Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 Medium Q9D9V3 Ethylmalonyl-CoA decarboxylase OS=Mus musculus OX=10090 GN=Echdc1 PE=1 SV=2 0.022 1.478 3 1 1 1 322 35.4 7.01 1 1 168693.7031 165968.4063 400881.4375 1 1 1 metabolic process cytoplasm;cytosol;mitochondrion catalytic activity Pf00378 52665 ENSMUSG00000019883.11 Echdc1 10 Propanoate metabolism 0 High P50637 Translocator protein OS=Mus musculus OX=10090 GN=Tspo PE=1 SV=1 0 4.324 8 1 1 1 169 18.8 9.52 1 1 27178.69531 98887.46094 126079.6172 743371.8125 1 1 1 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport membrane;mitochondrion protein binding;receptor activity;signal transducer activity Pf03073 12257 ENSMUSG00000041736.7 Tspo 15 Pregnenolone biosynthesis HTLV-I infection; Neuroactive ligand-receptor interaction 0 Medium Q80UG5 Septin-9 OS=Mus musculus OX=10090 GN=Septin9 PE=1 SV=1 0.027 1.369 1 1 1 1 583 65.5 8.9 1 1 cell division;cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton catalytic activity;nucleotide binding;protein binding "Pf00735, Pf01926, Pf03193, Pf04548" 53860 ENSMUSG00000059248.13 Sept9 11 Bacterial invasion of epithelial cells 0 High Q9QZZ6 Dermatopontin OS=Mus musculus OX=10090 GN=Dpt PE=1 SV=1 0 3.718 8 1 1 1 201 24 4.83 1 1 5271168 5005842 5384316 4745071 1 1 1 1 cell organization and biogenesis;regulation of biological process extracellular Pf14704 56429 ENSMUSG00000026574.5 Dpt 1 0 High Q69ZQ1 Myogenesis-regulating glycosidase OS=Mus musculus OX=10090 GN=Myorg PE=1 SV=2 0 2.379 1 1 1 1 716 81.3 8.29 1 1 68644.74219 131281.625 413702.4688 1 1 1 metabolic process;regulation of biological process membrane catalytic activity;protein binding Pf01055 329828 ENSMUSG00000046312.4 AI464131 4 0 High Q61425 "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Hadh PE=1 SV=2" 0.007 2.029 7 1 1 1 314 34.4 8.65 1 1 metabolic process;regulation of biological process;response to stimulus cytoplasm;membrane;mitochondrion;organelle lumen catalytic activity;nucleotide binding "Pf00070, Pf00725, Pf01266, Pf02737, Pf13450" 15107 ENSMUSG00000027984.8 Hadh 3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA "Fatty acid metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Lysine degradation; Fatty acid degradation; Butanoate metabolism; Fatty acid elongation" 0 High O35445 E3 ubiquitin-protein ligase RNF5 OS=Mus musculus OX=10090 GN=Rnf5 PE=1 SV=1 0 4.549 9 1 1 1 180 19.8 6.65 1 1 Met-loss+Acetyl [N-Term] metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane;mitochondrion catalytic activity;metal ion binding;protein binding "Pf00097, Pf12678, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634" 54197 ENSMUSG00000015478.13 Rnf5 17 ABC-family proteins mediated transport; ER Quality Control Compartment (ERQC) Protein processing in endoplasmic reticulum 0 Medium Q6NZQ4 PAX-interacting protein 1 OS=Mus musculus OX=10090 GN=Paxip1 PE=1 SV=1 0.032 1.259 2 1 1 1 1056 119.2 7.2 1 1 313569.875 1 cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus chromosome;nucleus protein binding "Pf00533, Pf12738" 55982 ENSMUSG00000002221.11 Paxip1 5 Nonhomologous End-Joining (NHEJ) 0 High A0A0G2JE92 Protein-tyrosine sulfotransferase (Fragment) OS=Mus musculus OX=10090 GN=Tpst2 PE=1 SV=1 0 4.119 13 1 1 1 122 13.4 9.63 1 1 127450.1563 72959.125 528074.875 1 1 1 metabolic process catalytic activity ENSMUSG00000029344.14 5 Cytosolic sulfonation of small molecules 0 Medium Q9CYQ7 Nuclear prelamin A recognition factor OS=Mus musculus OX=10090 GN=Narf PE=2 SV=1 0.04 1.12 2 1 1 1 462 51.8 6.52 1 1 902445.5625 679411.1875 639077.3125 1 1 1 metabolic process nucleus;organelle lumen catalytic activity;protein binding "Pf02256, Pf02906" 67608 ENSMUSG00000000056.7 Narf 11 0 Medium Q9D0K2 "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus OX=10090 GN=Oxct1 PE=1 SV=1" 0.021 1.549 3 1 1 1 520 56 8.53 1 1 370219.6875 342488.1563 1 1 metabolic process;regulation of biological process;response to stimulus mitochondrion;organelle lumen catalytic activity;protein binding Pf01144 67041 ENSMUSG00000022186.14 Oxct1 15 Utilization of Ketone Bodies "Valine, leucine and isoleucine degradation; Butanoate metabolism; Synthesis and degradation of ketone bodies" 0 Medium Q8CCM6 Mitochondrial import inner membrane translocase subunit Tim21 OS=Mus musculus OX=10090 GN=Timm21 PE=1 SV=2 0.022 1.484 4 1 1 1 244 27.9 9.95 1 1 1398278.875 1 0 High Q9R0N0 Galactokinase OS=Mus musculus OX=10090 GN=Galk1 PE=1 SV=2 0 2.685 2 1 1 1 392 42.3 5.26 1 1 376987.2188 2187251.25 2033506.875 3157972 1 1 1 1 metabolic process cytoplasm;membrane catalytic activity;nucleotide binding;protein binding "Pf08544, Pf10509" 14635 ENSMUSG00000020766.4 Galk1 11 Galactose catabolism Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Galactose metabolism 0 High E9PW43 Protein transport protein Sec61 subunit beta OS=Mus musculus OX=10090 GN=Gm10320 PE=3 SV=1 0 2.725 9 1 1 1 113 11.8 11.58 1 1 284472.9063 2144758.75 1 1 transport endoplasmic reticulum;membrane transporter activity Pf03911 ENSMUSG00000092116.1 13 XBP1(S) activates chaperone genes 0 Medium Q8K2F8 Protein LSM14 homolog A OS=Mus musculus OX=10090 GN=Lsm14a PE=1 SV=1 0.026 1.412 3 1 1 1 462 50.5 9.52 1 1 225830.9219 121265.0625 62196.86719 1 1 1 cell organization and biogenesis;defense response;development;regulation of biological process;response to stimulus cytoplasm;cytosol DNA binding;RNA binding "Pf09532, Pf12701, Pf14438" 67070 ENSMUSG00000066568.12 Lsm14a 7 0 Medium Q9D0B0 Serine/arginine-rich splicing factor 9 OS=Mus musculus OX=10090 GN=Srsf9 PE=1 SV=1 0.016 1.63 5 1 1 1 222 25.6 8.65 1 1 250444.8906 256610.3438 1 1 metabolic process;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 108014 ENSMUSG00000029538.14 Srsf9 5 mRNA Splicing - Major Pathway; mRNA 3'-end processing; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript Herpes simplex infection; Spliceosome 0 Medium Q8R323 Replication factor C subunit 3 OS=Mus musculus OX=10090 GN=Rfc3 PE=1 SV=1 0.04 1.104 2 1 1 1 356 40.5 8.38 1 1 597856.25 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding "Pf03215, Pf08542, Pf13177, Pf13401" 69263 ENSMUSG00000033970.15 Rfc3 5 Termination of translesion DNA synthesis; Polymerase switching on the C-strand of the telomere; Translesion synthesis by POLI; Activation of ATR in response to replication stress; Dual Incision in GG-NER; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Polymerase switching; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Translesion synthesis by REV1; G2/M DNA damage checkpoint DNA replication; Nucleotide excision repair; Mismatch repair 0 Low Q8R349 Cell division cycle protein 16 homolog OS=Mus musculus OX=10090 GN=Cdc16 PE=1 SV=1 0.056 0.95 3 1 1 1 620 71.4 5.76 1 1 449723.6563 1 cell division;metabolic process cytoplasm;nucleus protein binding "Pf00515, Pf07719, Pf12895, Pf13374, Pf13414, Pf13424" 69957 ENSMUSG00000038416.15 Cdc16 8 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Inactivation of APC/C via direct inhibition of the APC/C complex; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; Separation of Sister Chromatids; Phosphorylation of the APC/C; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Securin Progesterone-mediated oocyte maturation; Ubiquitin mediated proteolysis; HTLV-I infection; Oocyte meiosis; Cell cycle 0 High Q9CX86 Heterogeneous nuclear ribonucleoprotein A0 OS=Mus musculus OX=10090 GN=Hnrnpa0 PE=1 SV=1 0 3.352 7 1 1 1 305 30.5 9.31 1 1 defense response;regulation of biological process;response to stimulus nucleus protein binding;RNA binding "Pf00076, Pf13893, Pf14259" 77134 ENSMUSG00000007836.6 Hnrnpa0 13 mRNA Splicing - Major Pathway 0 Medium A0A1Y7VJ37 Tetraspanin-13 (Fragment) OS=Mus musculus OX=10090 GN=Tspan13 PE=1 SV=1 0.047 1.054 9 1 1 1 133 14.6 7.81 1 1 2185628.75 1 Met-loss [N-Term] regulation of biological process;response to stimulus membrane protein binding Pf00335 66109 Tspan13 12 0 High Q8BXC6 COMM domain-containing protein 2 OS=Mus musculus OX=10090 GN=Commd2 PE=1 SV=1 0 2.828 5 1 1 1 199 22.8 6.62 1 1 401466.7813 1 metabolic process;regulation of biological process cytoplasm Pf07258 52245 ENSMUSG00000036513.15 Commd2 3 0 High Q8VE19 GATOR complex protein MIOS OS=Mus musculus OX=10090 GN=Mios PE=1 SV=2 0 2.666 1 1 1 1 875 98.3 6.71 1 1 cell communication;regulation of biological process;response to stimulus membrane;vacuole protein binding 252875 ENSMUSG00000042447.13 Mios 6 mTOR signaling pathway 0 High D3Z2R5 Selenoprotein N OS=Mus musculus OX=10090 GN=Selenon PE=3 SV=2 0 7.4 3 1 1 1 557 62.5 5.55 1 1 2214904 1 cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus endoplasmic reticulum;membrane catalytic activity;metal ion binding 74777 ENSMUSG00000050989.9 Sepn1; Selenon 4 0 Low O35593 26S proteasome non-ATPase regulatory subunit 14 OS=Mus musculus OX=10090 GN=Psmd14 PE=1 SV=2 0.057 0.916 2 1 1 1 310 34.6 6.52 1 1 166470.8594 143905.8281 394512.9375 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus;proteasome catalytic activity;enzyme regulator activity;metal ion binding;protein binding "Pf01398, Pf13012, Pf14464" 59029 ENSMUSG00000026914.15 Psmd14 2 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; Metalloprotease DUBs; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome; Epstein-Barr virus infection 0 Medium P52825 "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Mus musculus OX=10090 GN=Cpt2 PE=1 SV=2" 0.027 1.367 1 1 1 1 658 73.9 8.37 1 1 119333.25 403949 1 1 metabolic process;transport membrane;mitochondrion catalytic activity Pf00755 12896 ENSMUSG00000028607.16 Cpt2 4 Import of palmitoyl-CoA into the mitochondrial matrix PPAR signaling pathway; Fatty acid metabolism; Fatty acid degradation 0 Low E9QP99 Golgin subfamily A member 3 OS=Mus musculus OX=10090 GN=Golga3 PE=1 SV=1 0.052 0.994 1 1 1 1 1487 167.2 5.38 1 1 474433.3125 216124.6406 201643.4063 159998.2188 1 1 1 1 cell differentiation;development;metabolic process;regulation of biological process cytoplasm;cytosol;Golgi;membrane;nucleus protein binding "Pf02463, Pf04111, Pf04156, Pf05557, Pf07888, Pf09726, Pf10186, Pf12128, Pf13166" 269682 ENSMUSG00000029502.14 Golga3 5 0 Low Q9CQU3 Protein RER1 OS=Mus musculus OX=10090 GN=Rer1 PE=1 SV=1 0.057 0.883 10 1 1 1 196 23 9.51 1 1 Met-loss+Acetyl [N-Term] cell organization and biogenesis;regulation of biological process;transport cell surface;Golgi;membrane protein binding Pf03248 67830 ENSMUSG00000029048.3 Rer1 4 0 Medium Q7TQK1 Integrator complex subunit 7 OS=Mus musculus OX=10090 GN=Ints7 PE=1 SV=1 0.014 1.723 1 1 1 1 966 106.8 8.22 1 1 metabolic process;response to stimulus chromosome;cytoplasm;cytosol;nucleus 77065 Ints7 1 0 High O88665 Bromodomain-containing protein 7 OS=Mus musculus OX=10090 GN=Brd7 PE=1 SV=1 0.008 1.963 4 1 1 1 651 74 6.38 1 1 222059.3906 213710.0313 274963.1563 578606.25 1 1 1 1 metabolic process;regulation of biological process;response to stimulus cytosol;nucleus DNA binding;protein binding "Pf00439, Pf12024" 26992 ENSMUSG00000031660.13 Brd7 8 Regulation of TP53 Activity through Acetylation 0 Low E9QLJ0 Cardiomyopathy-associated protein 5 OS=Mus musculus OX=10090 GN=Cmya5 PE=1 SV=1 0.056 0.959 1 1 1 1 3676 405.3 4.74 1 1 41561.8125 35178.17578 53720.3125 1 1 1 regulation of biological process cytoplasm protein binding "Pf00041, Pf00622" 76469 ENSMUSG00000047419.5 Cmya5 13 0 High Q9Z2U1 Proteasome subunit alpha type-5 OS=Mus musculus OX=10090 GN=Psma5 PE=1 SV=1 0 5.699 8 1 1 1 241 26.4 4.79 1 1 730676.5 1026310.875 1294572.75 1 1 1 metabolic process cytoplasm;cytosol;nucleus;proteasome catalytic activity "Pf00227, Pf10584" 26442 ENSMUSG00000068749.9 Psma5 3 The role of GTSE1 in G2/M progression after G2 checkpoint; CDT1 association with the CDC6:ORC:origin complex; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; UCH proteinases; MAPK6/MAPK4 signaling; SCF-beta-TrCP mediated degradation of Emi1; CDK-mediated phosphorylation and removal of Cdc6; Separation of Sister Chromatids; SCF(Skp2)-mediated degradation of p27/p21; GLI3 is processed to GLI3R by the proteasome; Ub-specific processing proteases; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Degradation of GLI1 by the proteasome; FCERI mediated NF-kB activation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Hedgehog ligand biogenesis; Neutrophil degranulation; Downstream TCR signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RAS by GAPs; Interleukin-1 family signaling; Asymmetric localization of PCP proteins; G2/M Checkpoints; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Regulation of PTEN stability and activity; Ubiquitin-dependent degradation of Cyclin D1; NIK-->noncanonical NF-kB signaling; Removal of licensing factors from origins; M/G1 Transition; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Cross-presentation of soluble exogenous antigens (endosomes); ABC-family proteins mediated transport; APC/C:Cdc20 mediated degradation of Securin; Regulation of DNA replication; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of RUNX3 expression and activity; Hedgehog 'on' state; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of DVL; Degradation of AXIN Proteasome 0 High Q9R118 Serine protease HTRA1 OS=Mus musculus OX=10090 GN=Htra1 PE=1 SV=2 0 2.92 3 1 1 1 480 51.2 7.65 1 1 253336.2188 308023.5 300860.9063 1 1 1 cell differentiation;metabolic process;regulation of biological process cytoplasm;cytosol;extracellular;membrane catalytic activity;protein binding "Pf00050, Pf00089, Pf00219, Pf00595, Pf07648, Pf10459, Pf13180, Pf13365" 56213 ENSMUSG00000006205.13 Htra1 7 0 High Q8BTY5 Proteasome subunit beta type-5 OS=Mus musculus OX=10090 GN=Psmb5 PE=1 SV=1 0 3.112 8 1 1 1 177 18.9 5.29 1 1 metabolic process;response to stimulus cytoplasm;nucleus;proteasome catalytic activity Pf00227 19173 Psmb5 14 0 High O35609 Secretory carrier-associated membrane protein 3 OS=Mus musculus OX=10090 GN=Scamp3 PE=1 SV=3 0.007 2.023 5 1 1 1 349 38.4 7.64 1 1 627009.25 743461.875 1 1 response to stimulus;transport membrane protein binding Pf04144 24045 ENSMUSG00000028049.15 Scamp3 3 0 Medium Q9JI95 CPN10-like protein OS=Mus musculus OX=10090 GN=Hspe1-rs1 PE=3 SV=1 0.034 1.2 10 1 1 1 102 11 8.92 1 1 119991.6797 111808.4375 589061.875 1 1 1 metabolic process cytoplasm Pf00166 628438 Hspe1-rs1 18 0 Medium Q9Z2X8 Kelch-like ECH-associated protein 1 OS=Mus musculus OX=10090 GN=Keap1 PE=1 SV=1 0.018 1.592 4 1 1 1 624 69.5 6.44 1 1 195084.9688 133782.25 144464.625 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;endoplasmic reticulum;nucleus catalytic activity;protein binding "Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964" 50868 ENSMUSG00000003308.15 Keap1 9 Neddylation; Ub-specific processing proteases Ubiquitin mediated proteolysis 0 High B1AUD7 P2X purinoceptor (Fragment) OS=Mus musculus OX=10090 GN=P2rx5 PE=3 SV=1 0 2.352 8 1 1 1 354 40.2 8.66 1 1 cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytosol;membrane metal ion binding;nucleotide binding;receptor activity;signal transducer activity;transporter activity Pf00864 94045 ENSMUSG00000005950.14 P2rx5 11 Elevation of cytosolic Ca2+ levels 0 High Q8CI95 Oxysterol-binding protein-related protein 11 OS=Mus musculus OX=10090 GN=Osbpl11 PE=1 SV=2 0 3.82 2 1 1 1 751 83.6 7.01 1 1 3860854 3768025.5 2903370.25 2920210.25 1 1 1 1 cell differentiation;regulation of biological process;transport endosome;Golgi;membrane "Pf00169, Pf01237, Pf15409" 106326 Osbpl11 16 0 Medium Q3USH5 "Splicing factor, suppressor of white-apricot homolog OS=Mus musculus OX=10090 GN=Sfswap PE=1 SV=2" 0.014 1.76 1 1 1 1 945 104.1 8.05 1 1 224545.9063 250843.6406 242490.6563 258642.0781 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process nucleus protein binding;RNA binding "Pf01805, Pf09750" 231769 ENSMUSG00000029439.14 Sfswap 5 0 High Q6GT24 Peroxiredoxin-6 OS=Mus musculus OX=10090 GN=Prdx6 PE=1 SV=1 0.01 1.899 4 1 1 1 224 24.8 6.37 1 1 80283.07813 199590.1875 149143.1563 313747.9063 1 1 1 1 cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;membrane;mitochondrion;nucleus;vacuole antioxidant activity;catalytic activity;protein binding "Pf00578, Pf08534, Pf10417" 11758 ENSMUSG00000026701.15 Prdx6 1 Neutrophil degranulation; Detoxification of Reactive Oxygen Species Metabolic pathways 0 High P62331 ADP-ribosylation factor 6 OS=Mus musculus OX=10090 GN=Arf6 PE=1 SV=2 0 2.355 9 1 1 1 175 20.1 8.95 1 1 cell death;cell differentiation;cell division;cell organization and biogenesis;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;endosome;Golgi;membrane catalytic activity;nucleotide binding;protein binding;signal transducer activity "Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439" 11845 ENSMUSG00000044147.7 Arf6 12 Clathrin-mediated endocytosis; MET receptor recycling; TBC/RABGAPs Endocytosis; Phospholipase D signaling pathway; Ras signaling pathway; Fc gamma R-mediated phagocytosis 0 Medium Q8K019 Bcl-2-associated transcription factor 1 OS=Mus musculus OX=10090 GN=Bclaf1 PE=1 SV=2 0.027 1.344 1 1 1 1 919 105.9 9.99 1 1 159541.6094 196510.1406 206857.2969 182233.3906 1 1 1 1 cell death;metabolic process;regulation of biological process;response to stimulus cytoplasm;nucleus DNA binding;protein binding;RNA binding Pf15440 72567 ENSMUSG00000037608.16 Bclaf1 10 0 Medium A0A494B9Y8 Ferrochelatase OS=Mus musculus OX=10090 GN=Fech PE=1 SV=1 0.012 1.81 2 1 1 1 366 41.6 9.36 1 1 406315.5 927717.75 623289.0625 705068.5625 1 1 1 1 0 High Q99KF1 Transmembrane emp24 domain-containing protein 9 OS=Mus musculus OX=10090 GN=Tmed9 PE=1 SV=2 0 4.075 5 1 1 1 235 27.1 8.41 1 1 702464.9375 1 cell organization and biogenesis;regulation of biological process;transport endoplasmic reticulum;Golgi;membrane protein binding Pf01105 67511 ENSMUSG00000058569.7 Tmed9 13 COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic 0 Low Q8VFG4 Olfactory receptor OS=Mus musculus OX=10090 GN=Olfr1370 PE=2 SV=1 0.057 0.919 3 1 1 1 316 35.3 8.9 1 1 1771753 17430994 1 1 Met-loss [N-Term] regulation of biological process;response to stimulus membrane receptor activity;signal transducer activity "Pf00001, Pf13853" 258528 ENSMUSG00000042869.2 Olfr1370 13 Olfactory transduction 0 High Q9DBE8 "Alpha-1,3/1,6-mannosyltransferase ALG2 OS=Mus musculus OX=10090 GN=Alg2 PE=1 SV=2" 0 5.007 3 1 1 1 415 47.4 7.97 1 1 946603.75 1 metabolic process;response to stimulus cytoplasm;membrane;nucleus catalytic activity;protein binding "Pf00534, Pf13439, Pf13524, Pf13579, Pf13692" 56737 ENSMUSG00000039740.6 Alg2 4 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" Metabolic pathways; N-Glycan biosynthesis 0 High P97333 Neuropilin-1 OS=Mus musculus OX=10090 GN=Nrp1 PE=1 SV=2 0 3.893 2 1 1 1 923 102.9 5.9 1 1 521679.9688 1 cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus;transport cell surface;cytosol;endosome;membrane catalytic activity;enzyme regulator activity;metal ion binding;protein binding;receptor activity;signal transducer activity "Pf00431, Pf00629, Pf00754, Pf11980" 18186 ENSMUSG00000025810.9 Nrp1 8 CRMPs in Sema3A signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; Sema3A PAK dependent Axon repulsion; Neurophilin interactions with VEGF and VEGFR Axon guidance; HTLV-I infection 0 High A0A0A6YX50 Protoporphyrinogen oxidase (Fragment) OS=Mus musculus OX=10090 GN=Ppox PE=1 SV=1 0 4.237 3 1 1 1 389 41.2 8.84 1 1 677756.8125 1 metabolic process membrane;mitochondrion catalytic activity "Pf01266, Pf01593, Pf13450" ENSMUSG00000062729.11 1 0 Medium Q64282 Interferon-induced protein with tetratricopeptide repeats 1 OS=Mus musculus OX=10090 GN=Ifit1 PE=1 SV=2 0.034 1.182 2 1 1 1 463 53.7 7.52 1 1 200236.6406 481157.9688 354029.625 733398.125 1 1 1 1 defense response;regulation of biological process;response to stimulus cytoplasm protein binding;RNA binding "Pf13414, Pf13432" 15957 ENSMUSG00000034459.8 Ifit1 19 Herpes simplex infection; Hepatitis C 0 Medium Q7TMG8 Glioblastoma amplified sequence OS=Mus musculus OX=10090 GN=Nipsnap2 PE=1 SV=1 0.034 1.172 4 1 1 1 281 32.9 9.33 1 1 353530.875 523078.9063 1 1 metabolic process;regulation of biological process cytoplasm;membrane;mitochondrion Pf07978 14467 ENSMUSG00000029432.12 Gbas; Nipsnap2 5 0 High Q9CZ42 ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Mus musculus OX=10090 GN=Naxd PE=1 SV=1 0 3.728 3 1 1 1 343 36.7 7.77 1 1 848398.0625 1 cytosol;endoplasmic reticulum;mitochondrion catalytic activity;nucleotide binding Pf01256 69225 Carkd; Naxd 8 0 Medium Q8BU14 Translocation protein SEC62 OS=Mus musculus OX=10090 GN=Sec62 PE=1 SV=1 0.021 1.565 2 1 1 1 398 45.6 7.31 1 1 521479.9375 1 cell organization and biogenesis;transport endoplasmic reticulum;membrane transporter activity Pf03839 69276 ENSMUSG00000027706.8 Sec62 3 XBP1(S) activates chaperone genes Protein export; Protein processing in endoplasmic reticulum 0 High P34884 Macrophage migration inhibitory factor OS=Mus musculus OX=10090 GN=Mif PE=1 SV=2 0.01 1.916 10 1 1 1 115 12.5 7.34 1 1 Met-loss [N-Term] cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus cell surface;cytoplasm;cytosol;extracellular;nucleus catalytic activity;protein binding Pf01187 17319 ENSMUSG00000033307.7 Mif 10 Cell surface interactions at the vascular wall; Neutrophil degranulation Phenylalanine metabolism; Tyrosine metabolism 0 Medium P97370 Sodium/potassium-transporting ATPase subunit beta-3 OS=Mus musculus OX=10090 GN=Atp1b3 PE=1 SV=1 0.034 1.162 3 1 1 1 278 31.8 8.51 1 1 267066.9063 1 cell organization and biogenesis;cellular homeostasis;regulation of biological process;transport cytoplasm;membrane catalytic activity;enzyme regulator activity;protein binding;transporter activity Pf00287 11933 ENSMUSG00000032412.8 Atp1b3 9 Ion transport by P-type ATPases; Ion homeostasis; Basigin interactions Pancreatic secretion; Carbohydrate digestion and absorption; Mineral absorption; Protein digestion and absorption; Endocrine and other factor-regulated calcium reabsorption; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Proximal tubule bicarbonate reclamation; cGMP-PKG signaling pathway; Bile secretion; Salivary secretion; Cardiac muscle contraction; cAMP signaling pathway; Gastric acid secretion; Insulin secretion; Adrenergic signaling in cardiomyocytes; Aldosterone-regulated sodium reabsorption 0 Low Q8CEZ1 Single-pass membrane and coiled-coil domain-containing protein 1 OS=Mus musculus OX=10090 GN=Smco1 PE=2 SV=3 0.058 0.821 3 1 1 1 214 24.5 9.1 1 1 98105.99219 122371.625 420632.7813 1 1 1 membrane Pf15080 69576 ENSMUSG00000046345.4 2310010M20Rik; Smco1 16 0 High A2AVJ7 Ribosome-binding protein 1 OS=Mus musculus OX=10090 GN=Rrbp1 PE=1 SV=1 0 2.786 2 1 1 1 1464 158.3 9.19 1 1 1946740.875 1 cell differentiation;metabolic process;regulation of biological process;transport endoplasmic reticulum;membrane;ribosome protein binding;receptor activity;RNA binding;structural molecule activity "Pf00038, Pf03276, Pf03962, Pf04111, Pf04156, Pf05104, Pf08317, Pf09606, Pf09726, Pf10186, Pf12128, Pf13779" 81910 ENSMUSG00000027422.15 Rrbp1 2 Protein processing in endoplasmic reticulum 0 Low Q3THK3 General transcription factor IIF subunit 1 OS=Mus musculus OX=10090 GN=Gtf2f1 PE=1 SV=2 0.057 0.937 2 1 1 1 508 57.2 7.01 1 1 823259 936582.1875 839543.5 770082.0625 1 1 1 1 metabolic process;regulation of biological process;response to stimulus nucleus catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding Pf05793 98053 ENSMUSG00000002658.9 Gtf2f1 17 mRNA Capping; RNA Polymerase II Transcription Initiation; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; mRNA Splicing - Major Pathway; RNA Pol II CTD phosphorylation and interaction with CE; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; RNA polymerase II transcribes snRNA genes; Formation of the Early Elongation Complex; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Basal transcription factors 0 High A0A0G2JFP4 Ferric-chelate reductase 1 OS=Mus musculus OX=10090 GN=Frrs1 PE=1 SV=1 0 2.639 2 1 1 1 592 66 8.32 1 1 439614.1875 1 metabolic process;transport membrane catalytic activity;metal ion binding "Pf02014, Pf03351" 20321 ENSMUSG00000033386.10 Frrs1 3 0 Medium P25962 Beta-3 adrenergic receptor OS=Mus musculus OX=10090 GN=Adrb3 PE=2 SV=2 0.018 1.605 3 1 1 1 400 43 9.38 1 1 cell communication;cell differentiation;regulation of biological process;response to stimulus membrane;nucleus protein binding;receptor activity;signal transducer activity Pf00001 11556 ENSMUSG00000031489.15 Adrb3 8 G alpha (s) signalling events; Adrenoceptors Endocytosis; Regulation of lipolysis in adipocytes; cGMP-PKG signaling pathway; Calcium signaling pathway; Salivary secretion; Renin secretion; Neuroactive ligand-receptor interaction 0 High Q8BJZ4 "28S ribosomal protein S35, mitochondrial OS=Mus musculus OX=10090 GN=Mrps35 PE=1 SV=2" 0.008 1.944 5 1 1 1 320 36 8.59 1 1 mitochondrion;ribosome RNA binding;structural molecule activity Pf10213 232536 Mrps35 6 0 High Q3TSU5 Alpha-mannosidase 2x OS=Mus musculus OX=10090 GN=Man2a2 PE=1 SV=1 0 3.268 2 1 1 1 583 66.5 7.18 1 1 840687.9375 1 metabolic process Golgi;membrane catalytic activity;metal ion binding "Pf01074, Pf09261" 140481 ENSMUSG00000038886.10 Man2a2 7 0 Medium Q9D823 60S ribosomal protein L37 OS=Mus musculus OX=10090 GN=Rpl37 PE=3 SV=3 0.047 1.031 10 1 1 1 97 11.1 11.74 1 1 3102561 1955814.125 1319223.625 1 1 1 Met-loss [N-Term] metabolic process ribosome metal ion binding;protein binding;RNA binding;structural molecule activity Pf01907 100502825; 67281 ENSMUSG00000041841.7 Gm13826; Rpl37rt; Rpl37 5; 15 L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane Ribosome 0 High Q8VCS6 Mediator of RNA polymerase II transcription subunit 9 OS=Mus musculus OX=10090 GN=Med9 PE=2 SV=1 0 3.002 16 1 1 1 142 15.7 7.44 1 1 metabolic process;regulation of biological process nucleus protein binding Pf07544 192191 ENSMUSG00000061650.6 Med9 11 Mus musculus biological processes; Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes 0 High A0A2R8VK76 Cleavage and polyadenylation-specificity factor subunit 1 OS=Mus musculus OX=10090 GN=Cpsf1 PE=1 SV=1 0 4.498 1 1 1 1 1450 161.7 6.58 1 1 0 High D3YWT0 Signal peptidase complex catalytic subunit SEC11 OS=Mus musculus OX=10090 GN=Sec11a PE=1 SV=1 0 3.127 5 1 1 1 170 19.6 9.48 1 1 76820.88281 931087.75 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity Pf00717 ENSMUSG00000025724.12 7 0 Low Q91Z40 Gbp6 protein OS=Mus musculus OX=10090 GN=Gbp7 PE=1 SV=2 0.053 0.987 1 1 1 1 638 72.7 6.33 1 1 259403.3438 816430.5625 839303.75 961375 1 1 1 1 defense response;response to stimulus catalytic activity;nucleotide binding "Pf02263, Pf02841, Pf05879" 229900 ENSMUSG00000040253.15 Gbp7 3 NOD-like receptor signaling pathway 0 High E9PUD2 Dynamin-1-like protein OS=Mus musculus OX=10090 GN=Dnm1l PE=1 SV=1 0.007 1.996 1 1 1 1 712 79.5 7.08 1 1 386280.6875 270989.2188 844280.6875 1 1 1 cell death;cell organization and biogenesis;regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion catalytic activity;nucleotide binding;protein binding "Pf00350, Pf01031, Pf02212" 74006 ENSMUSG00000022789.14 Dnm1l 16 0 Low Q8CC47 N-acetylgalactosamine-6-sulfatase OS=Mus musculus OX=10090 GN=Galns PE=1 SV=1 0.055 0.967 2 1 1 1 440 48.5 6.52 1 1 metabolic process vacuole catalytic activity;metal ion binding "Pf00884, Pf01663, Pf02995, Pf14707" 50917 ENSMUSG00000015027.11 Galns 8 0 Medium Q9JHJ0 Tropomodulin-3 OS=Mus musculus OX=10090 GN=Tmod3 PE=1 SV=1 0.014 1.737 3 1 1 1 352 39.5 5.14 1 1 311174.0938 338020.875 1 1 cell organization and biogenesis;regulation of biological process cytoplasm;cytoskeleton protein binding Pf03250 50875 ENSMUSG00000058587.8 Tmod3 9 0 Medium Q9DBJ1 Phosphoglycerate mutase 1 OS=Mus musculus OX=10090 GN=Pgam1 PE=1 SV=3 0.016 1.657 7 1 1 1 254 28.8 7.18 1 1 70065.23438 392137.5625 1 1 metabolic process;regulation of biological process cytoplasm;cytosol;membrane;nucleus catalytic activity;protein binding Pf00300 18648 ENSMUSG00000011752.6 Pgam1 19 Neutrophil degranulation; Gluconeogenesis; Glycolysis "Metabolic pathways; Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism; Central carbon metabolism in cancer; Glucagon signaling pathway" 0 High Q8VE95 UPF0598 protein C8orf82 homolog OS=Mus musculus OX=10090 PE=1 SV=1 0 2.658 4 1 1 1 218 24.3 8.7 1 1 338427.0625 1 regulation of biological process mitochondrion Pf14956 223665 ENSMUSG00000033707.8 C030006K11Rik 15 0 High Q99P87 Resistin OS=Mus musculus OX=10090 GN=Retn PE=1 SV=1 0.001 2.219 12 1 1 1 114 12.5 7.75 1 1 29867970 129481832 103912000 107891400 1 1 1 1 cell differentiation;regulation of biological process;response to stimulus extracellular;nucleus protein binding Pf06954 57264 ENSMUSG00000012705.16 Retn 8 Neutrophil degranulation 0 Low P08043 Zinc finger protein 2 OS=Mus musculus OX=10090 GN=Zfp2 PE=2 SV=2 0.058 0.85 2 1 1 1 459 52.5 8.82 1 1 114778.5078 375158.8438 340891 660553.9375 1 1 1 1 metabolic process;regulation of biological process nucleus DNA binding;metal ion binding "Pf00096, Pf13465" 22678 ENSMUSG00000049321.17 Zfp2 11 0 Medium D3Z494 "Aldo-keto reductase family 1, member B10 (aldose reductase) OS=Mus musculus OX=10090 GN=Akr1b10 PE=1 SV=1" 0.022 1.471 4 1 1 1 288 32.7 7.01 1 1 78863.96875 83073.46875 90076.10156 161441.2188 1 1 1 1 Met-loss+Acetyl [N-Term] metabolic process mitochondrion catalytic activity Pf00248 ENSMUSG00000061758.13 6 Estrogen biosynthesis; Signaling by GPCR; Retinoid metabolism and transport 0 Medium Q9EQQ2 Protein YIPF5 OS=Mus musculus OX=10090 GN=Yipf5 PE=1 SV=1 0.047 1.036 4 1 1 1 257 27.9 4.36 1 1 811095.5625 1 regulation of biological process;transport endoplasmic reticulum;Golgi;membrane 67180 ENSMUSG00000024487.4 Yipf5 18 0 High P61022 Calcineurin B homologous protein 1 OS=Mus musculus OX=10090 GN=Chp1 PE=1 SV=2 0 3.273 6 1 1 1 195 22.4 5.1 1 1 915079.4375 1 cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus enzyme regulator activity;metal ion binding;protein binding;transporter activity "Pf00036, Pf12174, Pf13405, Pf13499, Pf13833" 56398 ENSMUSG00000014077.13 1500003O03Rik; Chp1 2 Hyaluronan uptake and degradation 0 Low A0A0G2JGU3 ATP-dependent RNA helicase DHX30 (Fragment) OS=Mus musculus OX=10090 GN=Dhx30 PE=1 SV=1 0.058 0.846 16 1 1 1 49 5.6 10.8 1 1 87085.35156 286535.8125 268886.5313 1059134.75 1 1 1 1 Met-loss [N-Term] ENSMUSG00000032480.17 9 0 Medium P61161 Actin-related protein 2 OS=Mus musculus OX=10090 GN=Actr2 PE=1 SV=1 0.012 1.822 3 1 1 1 394 44.7 6.74 1 1 544247.625 1 cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport cytoplasm;cytoskeleton;cytosol;membrane nucleotide binding;protein binding;structural molecule activity Pf00022 66713 ENSMUSG00000020152.7 Actr2 11 RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation 0 Low Q99PP2 Zinc finger protein 318 OS=Mus musculus OX=10090 GN=Znf318 PE=1 SV=3 0.057 0.92 0 1 1 1 2237 246.2 7.01 1 1 416033.375 326719.5 467126.1563 1 1 1 0 Low Q9QYC7 Vitamin K-dependent gamma-carboxylase OS=Mus musculus OX=10090 GN=Ggcx PE=1 SV=1 0.06 0.798 1 1 1 1 757 87.1 8.02 1 1 255275.6719 2756931.25 1 1 metabolic process endoplasmic reticulum;membrane catalytic activity Pf05090 56316 ENSMUSG00000053460.8; ENSMUSG00000103019.2 Ggcx 6; CHR_MG184_PATCH Gamma-carboxylation of protein precursors Ubiquinone and other terpenoid-quinone biosynthesis 0 Medium P00920 Carbonic anhydrase 2 OS=Mus musculus OX=10090 GN=Ca2 PE=1 SV=4 0.034 1.157 3 1 1 1 260 29 7.01 1 1 125845.3047 436653.2813 1 1 cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport cytoplasm;cytosol;membrane catalytic activity;metal ion binding Pf00194 12349 ENSMUSG00000027562.12 Car2 3 Erythrocytes take up carbon dioxide and release oxygen; Reversible hydration of carbon dioxide; Erythrocytes take up oxygen and release carbon dioxide Pancreatic secretion; Nitrogen metabolism; Proximal tubule bicarbonate reclamation; Bile secretion; Gastric acid secretion; Collecting duct acid secretion 0 Medium Q9WTL4 Insulin receptor-related protein OS=Mus musculus OX=10090 GN=Insrr PE=1 SV=2 0.035 1.143 1 1 1 1 1300 144.8 6.64 1 1 2050621.5 855200.3125 373371.4375 1496168.5 1 1 1 1 cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus membrane catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity "Pf00041, Pf00069, Pf00757, Pf01030, Pf05287, Pf07714" 23920 ENSMUSG00000005640.11 Insrr 3 Regulation of actin cytoskeleton; Prostate cancer 0 Low O08641 SH3 domain-containing YSC84-like protein 1 OS=Mus musculus OX=10090 GN=Sh3yl1 PE=1 SV=1 0.059 0.804 4 1 1 1 340 37 8.97 1 1 179507.8125 741470.25 1 1 Acetyl [N-Term] metabolic process;regulation of biological process protein binding "Pf00018, Pf04366, Pf07653, Pf14604" 24057 ENSMUSG00000020669.15 Sh3yl1 12 0 Medium Q91YX5 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Mus musculus OX=10090 GN=Lpgat1 PE=1 SV=1 0.04 1.116 3 1 1 1 370 43.1 8.79 1 1 metabolic process;regulation of biological process cytoplasm;endoplasmic reticulum;membrane catalytic activity Pf01553 226856 ENSMUSG00000026623.16 Lpgat1 1 Acyl chain remodelling of PG Glycerophospholipid metabolism 0 High P58059 "28S ribosomal protein S21, mitochondrial OS=Mus musculus OX=10090 GN=Mrps21 PE=1 SV=1" 0 5.381 15 1 1 1 87 10.6 10.32 1 1 203896.8125 774140.125 606307.875 1068389.25 1 1 1 1 cell organization and biogenesis;metabolic process membrane;mitochondrion;ribosome RNA binding;structural molecule activity 66292 ENSMUSG00000054312.6 Mrps21 3 Ribosome 0 High Q8VCM8 Nicalin OS=Mus musculus OX=10090 GN=Ncln PE=1 SV=2 0 2.964 2 1 1 1 563 62.9 6.49 1 1 metabolic process;regulation of biological process endoplasmic reticulum;membrane "Pf04389, Pf05450" 103425 ENSMUSG00000020238.14 Ncln 10 0 Medium A0A075B5L7 Immunoglobulin kappa variable 4-80 (Fragment) OS=Mus musculus OX=10090 GN=Igkv4-80 PE=4 SV=2 0.012 1.855 14 1 1 1 116 12.6 5.15 1 1 153893.0313 345449.0625 516515.5625 517979.2813 1 1 1 1 response to stimulus "Pf00047, Pf07679, Pf07686" 545848 ENSMUSG00000076540.3 Igkv4-80 6 0 High O08538 Angiopoietin-1 OS=Mus musculus OX=10090 GN=Angpt1 PE=1 SV=2 0 2.762 2 1 1 1 498 57.5 6.76 1 1 1822080.875 1 cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus extracellular;membrane protein binding "Pf00147, Pf13851" 11600 ENSMUSG00000022309.8 Angpt1 15 RAF/MAP kinase cascade; Interleukin-20 family signaling; Tie2 Signaling Ras signaling pathway; Rheumatoid arthritis; Rap1 signaling pathway; HIF-1 signaling pathway; PI3K-Akt signaling pathway 0 High A0A0A6YWA6 Neprilysin (Fragment) OS=Mus musculus OX=10090 GN=Mme PE=1 SV=1 0 2.507 7 1 1 1 130 14.4 5.25 1 1 865245.4375 1 metabolic process membrane catalytic activity Pf05649 ENSMUSG00000027820.12 3 0 Medium A0A2I3BS14 Carboxypeptidase Q (Fragment) OS=Mus musculus OX=10090 GN=Cpq PE=1 SV=1 0.027 1.334 7 1 1 1 198 22 9.07 1 1 0 Medium Q5SF07 Insulin-like growth factor 2 mRNA-binding protein 2 OS=Mus musculus OX=10090 GN=Igf2bp2 PE=1 SV=1 0.024 1.418 2 1 1 1 592 65.5 8.03 1 1 493500.2813 619889.8125 399241.4375 484353.1875 1 1 1 1 regulation of biological process;transport cytoplasm;cytoskeleton;cytosol;nucleus RNA binding "Pf00013, Pf00076, Pf13014, Pf13893, Pf14259" 319765 ENSMUSG00000033581.16 Igf2bp2 16 0 High Q8BP71 RNA binding protein fox-1 homolog 2 OS=Mus musculus OX=10090 GN=Rbfox2 PE=1 SV=2 0.001 2.214 2 1 1 1 449 47.3 6.55 1 1 575690.0625 1 cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus cytoplasm;cytosol;nucleus protein binding;RNA binding "Pf00076, Pf12414, Pf13893, Pf14259" 93686 ENSMUSG00000033565.16 Rbfox2 15 FGFR2 alternative splicing 0